Beneath the Surface: The Secret to Prexasertib’s Potential
Beneath the surface of Prexasertib’s clinical potential lies a complex and often overlooked story of molecular precision. Developed by Eli Lilly as a checkpoint kinase 1 and 2 (CHK1,2) inhibitor, Prexasertib operates through a finely tuned mechanism that disrupts tumor cell survival. By suppressing CHK1 and CHK2 activity, it downregulates Cdc25A, preventing cyclin-dependent kinase (CDC) […]
Combination Therapy: How to optimize drug synergies and disease modulation?
𝗖𝗼𝗺𝗯𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗧𝗵𝗲𝗿𝗮𝗽𝘆: 𝗛𝗼𝘄 𝘁𝗼 𝗼𝗽𝘁𝗶𝗺𝗶𝘇𝗲 𝗱𝗿𝘂𝗴 𝘀𝘆𝗻𝗲𝗿𝗴𝗶𝗲𝘀 𝗮𝗻𝗱 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 𝗺𝗼𝗱𝘂𝗹𝗮𝘁𝗶𝗼𝗻❓ Pathway profiling is powerful for quantifying monitoring disease modulation. Quantify 800 proteins per sample and get all data you need for drug repurposing, combination therapy optimization, and drug resistance analysis. Request the latest Hyperplex™ assay menu now and customize your pathway profiling assay from pre-validated […]
Quantify Pathway Modulation?
Comprehensive pathway analysis has become easy: Quantify 800 (!) proteins per sample. Learn more about Hyperplex™ now: https://lnkd.in/eTvHA7Z
Quantify Changes in Cell Signaling?
Comprehensive cell signaling analysis has become easy: Quantify 800 (!) proteins per sample. Learn more about Hyperplex™ now: https://lnkd.in/efbBt9f
Mechanism of action (MoA): Hyperplex to elucidate MOA and quantify pathway modulation
Mechanism of action (MoA): Learn how Bayer uses Hyperplex to elucidate MOA and quantifypathway modulation. HyperplexTV is the most comprehensive pathway analysis platform in themarket (> 1,250 biomarkers, > 300 phosphoproteins). Eliminate guesswork: Get an actionabledata package (incl. heatmaps, volcano plots, pathway maps) now. Learn about our servicepackages:1. Discovery. Compound profiling, quantitative benchmarking.2. Pharmacology. Target […]
Grant for cell signaling research
Grant for cell signaling research: You can now quantify 800 (!) proteins from just 20 μg of sample. Learn more about the 2021 Grant Application now! AssayEngineers (Germany) now invites researchers to apply for the 2021 Pathway Activation Profiling Grant. >>> Simply share this post with your community and we will invite you to participate […]
Studying cell-cell communication and signaling
Cell-cell communication drives cancer progression and influences therapy response. A new article examines how different cell types within the TME work together to drive cancer and considers the multiple signals present between and within different cancers. To study how tissues function, we need a model that measures both how signals are transmitted between cells and […]
Plasma proteins relating to Alzheimer’s pathology
Here is an interesting study linking ~4000 #Somalogic plasma proteins to #alzheimers (amyloid/tau/neurodegeneration). Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment, and 191 AD) were measured using both #SOMAscan and targeted #Luminex assays, including 4001 and 25 proteins, respectively. Results suggest that blood proteins can predict the presence of AD pathology. Check […]
Hyperplex™ panel quantifies 47 drug targets of FDA-approved drugs
We are proudly launching a new 47-plex drug target assay today! Based on proprietary Hyperplex™ technology the panel quantifies 47 drug targets of FDA-approved drugs (see below). Hyperplex™ is the most comprehensive pathway analysis platform in the market (>1,250 biomarkers, >400 phosphoproteins). Talk to a scientist today: hello@assay-engineers.com Drugs in the panel: Abemaciclib Afatinib Axitinib […]
𝐆𝐫𝐞𝐚𝐭 𝐬𝐭𝐮𝐝𝐲 𝐨𝐧 𝐍𝐞𝐱𝐭 𝐆𝐞𝐧 𝐏𝐥𝐚𝐬𝐦𝐚 𝐏𝐫𝐨𝐭𝐞𝐨𝐦𝐞 𝐏𝐫𝐨𝐟𝐢𝐥𝐢𝐧𝐠
Folks, check out this nice work: Over the past decade, #Precisionmedicine has been dominated by genomics platforms. Today, targeted #proteomics platforms like #somalogic, #OLINK, and #Hyperplex enable comprehensive profiling of patients before and during therapeutic interventions. Recently, #OLINK assays have been used to quantify protein plasma levels in longitudinal studies. The authors show that this […]