Combination Therapy: How to optimize drug synergies and disease modulation?
๐๐ผ๐บ๐ฏ๐ถ๐ป๐ฎ๐๐ถ๐ผ๐ป ๐ง๐ต๐ฒ๐ฟ๐ฎ๐ฝ๐: ๐๐ผ๐ ๐๐ผ ๐ผ๐ฝ๐๐ถ๐บ๐ถ๐๐ฒ ๐ฑ๐ฟ๐๐ด ๐๐๐ป๐ฒ๐ฟ๐ด๐ถ๐ฒ๐ ๐ฎ๐ป๐ฑ ๐ฑ๐ถ๐๐ฒ๐ฎ๐๐ฒ ๐บ๐ผ๐ฑ๐๐น๐ฎ๐๐ถ๐ผ๐ปโ Pathway profiling is powerful for quantifying monitoring disease modulation. Quantify 800 proteins per sample and get all data you need for drug repurposing, combination therapy optimization, and drug resistance analysis. Request the latest Hyperplexโข assay menu now and customize your pathway profiling assay from pre-validated […]
Quantify Pathway Modulation?
Comprehensive pathway analysis has become easy: Quantify 800 (!) proteins per sample. Learn more about Hyperplexโข now: https://lnkd.in/eTvHA7Z
Quantify Changes in Cell Signaling?
Comprehensive cell signaling analysis has become easy: Quantify 800 (!) proteins per sample. Learn more about Hyperplexโข now: https://lnkd.in/efbBt9f
Mechanism of action (MoA): Hyperplex to elucidate MOA and quantify pathway modulation
Mechanism of action (MoA): Learn how Bayer uses Hyperplex to elucidate MOA and quantifypathway modulation. HyperplexTV is the most comprehensive pathway analysis platform in themarket (> 1,250 biomarkers, > 300 phosphoproteins). Eliminate guesswork: Get an actionabledata package (incl. heatmaps, volcano plots, pathway maps) now. Learn about our servicepackages:1. Discovery. Compound profiling, quantitative benchmarking.2. Pharmacology. Target […]
Grant for cell signaling research
Grant for cell signaling research: You can now quantify 800 (!) proteins from just 20 ฮผg of sample. Learn more about the 2021 Grant Application now! AssayEngineers (Germany) now invites researchers to apply for the 2021 Pathway Activation Profiling Grant. >>> Simply share this post with your community and we will invite you to participate […]
Studying cell-cell communication and signaling
Cell-cell communication drives cancer progression and influences therapy response. A new article examines how different cell types within the TME work together to drive cancer and considers the multiple signals present between and within different cancers. To study how tissues function, we need a model that measures both how signals are transmitted between cells and […]
Plasma proteins relating to Alzheimer’s pathology
Here is an interesting study linking ~4000 #Somalogic plasma proteins to #alzheimers (amyloid/tau/neurodegeneration). Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment, and 191 AD) were measured using both #SOMAscan and targeted #Luminex assays, including 4001 and 25 proteins, respectively. Results suggest that blood proteins can predict the presence of AD pathology. Check […]
Hyperplexโข panel quantifies 47 drug targets of FDA-approved drugs
We are proudly launching a new 47-plex drug target assay today! Based on proprietary Hyperplexโข technology the panel quantifies 47 drug targets of FDA-approved drugs (see below). Hyperplexโข is the most comprehensive pathway analysis platform in the market (>1,250 biomarkers, >400 phosphoproteins). Talk to a scientist today: hello@assay-engineers.com Drugs in the panel: Abemaciclib Afatinib Axitinib […]
๐๐ซ๐๐๐ญ ๐ฌ๐ญ๐ฎ๐๐ฒ ๐จ๐ง ๐๐๐ฑ๐ญ ๐๐๐ง ๐๐ฅ๐๐ฌ๐ฆ๐ ๐๐ซ๐จ๐ญ๐๐จ๐ฆ๐ ๐๐ซ๐จ๐๐ข๐ฅ๐ข๐ง๐
Folks, check out this nice work: Over the past decade, #Precisionmedicine has been dominated by genomics platforms. Today, targeted #proteomics platforms like #somalogic, #OLINK, and #Hyperplex enable comprehensive profiling of patients before and during therapeutic interventions. Recently, #OLINK assays have been used to quantify protein plasma levels in longitudinal studies. The authors show that this […]
๐๐๐๐ง๐ญ๐ข๐๐ฒ ๐ง๐จ๐ฏ๐๐ฅ ๐๐ซ๐ฎ๐ ๐ญ๐๐ซ๐ ๐๐ญ๐ฌ ๐ -๐๐จ๐ฌ๐ญ-๐ญ๐ซ๐๐ง๐ฌ๐ฅ๐๐ญ๐ข๐จ๐ง๐๐ฅ ๐ฆ๐จ๐๐ข๐๐ข๐๐๐ญ๐ข๐จ๐ง๐ฌ ๐๐ง๐ ๐ฉ๐ซ๐จ๐ญ๐๐ข๐ง ๐ฌ๐ญ๐๐๐ข๐ฅ๐ข๐ญ๐ฒ
Check out this fascinating review on Post-translational modifications (PTM) addressing the regulation of protein stability. P TMs affect all aspects of protein function, and one crucial aspect is a protein’s proteolytic stability. In this Nature Communications review, Lee and co-authors have brilliantly summarized the current knowledge of the regulation of protein stability by various PTMs. […]