Check out this fascinating review on Post-translational modifications (PTM) addressing the regulation of protein stability. P TMs affect all aspects of protein function, and one crucial aspect is a protein’s proteolytic stability.
In this Nature Communications review, Lee and co-authors have brilliantly summarized the current knowledge of the regulation of protein stability by various PTMs. They delve into the intricate details of PTMs occurring on specific amino acids within regulatory domains of target proteins, which ultimately control a protein’s stability.
What makes this review truly remarkable is the comprehensive display of the variety and breadth of known mechanisms of regulation. The authors also shed light on common themes in PTM-reguIated degrons, opening doors to the identification of novel drug targets in areas where druggable targets are currently lacking.
Understanding the intricate relationship between P TMs and protein stability holds immense potential for the development of innovative therapeutic strategies. By identifying novel drug targets, we can pave the way for the discovery of breakthrough treatments and interventions for a wide range of diseases.
Whether you’re a researcher, scientist, or simply fascinated by the world of molecular biology, this review is a must-read. Join the conversation and gain valuable insights into the latest advancements in PTM research.
