{"text_format":"1","workbook":"xlsx","n_sheets":5,"sheets":["Intro","All Antibody Panels","Code_Sheet","Panel_Overview","Pathway Activity Panels"],"not_rendered":{"charts":0,"images":1,"macros":1,"external_links":0,"defined_names":2,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Intro","index":0,"n_rows":24,"n_cols":3,"rows_kept":24,"cut":false,"hidden":false,"merged":[[4,1,4,8],[7,1,7,7],[8,1,8,7],[9,1,9,7]]}
[]
[null,"Hyperplex® Multiplex Protein Profiling"]
[null,"Version 9.5, September 7th 2023"]
[]
[null,"Dear Customer, \nUsing this cell signaling assay configurator, you can easily customize your markerset in five steps:"]
[null,"① Select information"]
[null,"② Select one or more species"]
[null,"③ Select pathway activity panels"]
[null,"④ Select druggable pathways"]
[null,"⑤ Sheet \"All Antibody Panels, Row \"F\", select ('X') or add more analytes manually ('X')."]
[null,"Save the file and e-mail to hello@assay-engineers.com and get you cost estimate within 2 days."]
[]
[null,"Antibody Scores:"," According to the system proposed by Björling & Uhlén, MCP 2008, 7:2028-37."]
[null,1," Single peak of expected molecular weight"]
[null,2," Clear peak of expected molecular weight, plus minor side bands"]
[null,3," Clear peak, of higher or lower size than expected, but with indication of right identity"]
[null,4," No peak (e.g. cases of phospho antibodies)"]
[null,5," Single peak of higher or lower size than expected"]
[null,6," Weak peak of expected size, but major side bands"]
[null,7," Multiple peaks, none of expected size"]
[null,8," Additional NMI category: No peak in this species but validated in other species"]
[null,"n/a"," Validation data not available yet"]
[]
[null,"© AssayEngineers, Germany, 2023"]

{"sheet":"All Antibody Panels","index":1,"n_rows":1270,"n_cols":40,"rows_kept":1270,"cut":false,"hidden":false,"merged":[[0,34,0,36],[0,37,0,39],[0,0,0,4],[0,6,0,11],[0,14,0,19],[0,20,0,27],[0,28,0,33]]}
[null,null,null,null,null,{"$f":"COUNTA(F3:F1270)","v":0},"Score",null,null,null,null,null,null,null,"Functional Information",null,null,null,null,null,"NCBI Gene Information",null,null,null,null,null,null,null,"Uniprot Ids",null,null,null,null,null,"GO Terms",null,null,"Panther Ids"]
["antigen_name","antigen_modification_site","ncbi_gene_name_human","molweight_human","antibody_supplier_source","Selection\n(X)","score_digiwest_human","score_digiwest_mouse","score_digiwest_rat","score_digiwest_dog","score_digiwest_minipig","score_digiwest_cynomolgus","nmi_antibody_id_unique_identifier_RT","Pathway_Search_Tag","Panther_Pathway_name","Panther_family","GO_process_term_defs","GO_function_term_defs","GO_component_term_defs","primary_gene_function","ncbi_gene_summary_human","ncbi_gene_URL_human","ncbi_gene_id_human","ncbi_gene_id_mouse","ncbi_gene_id_rat","ncbi_gene_id_dog","ncbi_gene_id_minipig","ncbi_gene_id_cynomolgus","uniprot_id_human","uniprot_id_mouse","uniprot_id_rat","uniprot_id_dog","uniprot_id_minipig","uniprot_id_cynomolgus","GO_component_terms","GO_function_terms","GO_process_terms","Panther_id","Panther_url","Pathway_accession"]
["14-3-3 epsilon",null,"YWHAE","28","rb",null,1,1,2,1,1,1,"# 2310",".CCP., .CCY., .CSP., .DEV., .DI., .EGFR., .FGFR., .HIPPO., .MAPK., .MIG., .OP., .OPA., .OT., .PARK., .PI3K., .RTK., .ST.","FGF signaling pathway; Parkinson disease; EGF receptor signaling pathway","14-3-3 PROTEIN EPSILON","cellular response to heat; cerebral cortex development; hippocampus development; intracellular signal transduction; MAPK cascade; membrane repolarization during cardiac muscle cell action potential; negative regulation of calcium ion export across plasma membrane; negative regulation of calcium ion transmembrane transporter activity; negative regulation of peptidyl-serine dephosphorylation; negative regulation of protein dephosphorylation; neuron migration; positive regulation of protein export from nucleus; protein localization to nucleus; protein targeting; regulation of cytosolic calcium ion concentration; regulation of heart rate by cardiac conduction; regulation of heart rate by hormone; regulation of membrane repolarization; regulation of mitotic cell cycle; regulation of potassium ion transmembrane transporter activity; signal transduction; substantia nigra development","cadherin binding; calcium channel regulator activity; enzyme binding; histone deacetylase binding; identical protein binding; MHC class II protein complex binding; phosphoprotein binding; phosphoserine residue binding; potassium channel regulator activity; protein binding; protein domain specific binding; protein heterodimerization activity; protein phosphatase binding; RNA binding; scaffold protein binding; transmembrane transporter binding; ubiquitin protein ligase binding","cytoplasm; cytosol; extracellular exosome; focal adhesion; melanosome; membrane; nucleus; plasma membrane","Tyrosine kinase / adaptor","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon","http://www.ncbi.nlm.nih.gov/gene/?term=7531","7531","22627","29753","480645",null,"720156","P62258","P62259","P62260","A0A8I3NMG3","A0A8W4FFP1","A0A1D5Q9M4","GO:0005737; GO:0005829; GO:0070062; GO:0005925; GO:0042470; GO:0016020; GO:0005634; GO:0005886","GO:0045296; GO:0005246; GO:0019899; GO:0042826; GO:0042802; GO:0023026; GO:0051219; GO:0050815; GO:0015459; GO:0005515; GO:0019904; GO:0046982; GO:0019903; GO:0003723; GO:0097110; GO:0044325; GO:0031625","GO:0034605; GO:0021987; GO:0021766; GO:0035556; GO:0000165; GO:0086013; GO:1905913; GO:1901020; GO:1902309; GO:0035308; GO:0001764; GO:0046827; GO:0034504; GO:0006605; GO:0051480; GO:0086091; GO:0003064; GO:0060306; GO:0007346; GO:1901016; GO:0007165; GO:0021762","PTHR18860:SF67","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12851|UniProtKB=P62258","P00021; P00049; P00018"]
["14-3-3 sigma",null,"SFN","28","gt",null,2,2,2,2,1,1,"# 1020",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DI., .EGFR., .FGFR., .OP., .OPA., .P53S., .PARK., .RTK., .ST.","p53 pathway; FGF signaling pathway; Parkinson disease; EGF receptor signaling pathway","14-3-3 PROTEIN SIGMA","establishment of skin barrier; intrinsic apoptotic signaling pathway in response to DNA damage; keratinization; keratinocyte development; keratinocyte differentiation; keratinocyte proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of keratinocyte proliferation; negative regulation of protein kinase activity; negative regulation of stem cell proliferation; positive regulation of cell growth; positive regulation of epidermal cell differentiation; positive regulation of protein export from nucleus; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of epidermal cell division; release of cytochrome c from mitochondria; signal transduction; skin development; stem cell proliferation","cadherin binding; identical protein binding; phosphoprotein binding; protein binding; protein kinase binding; protein kinase C inhibitor activity","cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular space; nucleus","Tyrosine kinase / adaptor","stratifin","http://www.ncbi.nlm.nih.gov/gene/?term=2810","2810","55948","298795",null,null,"715055","P31947","O70456","Q5EBB0",null,null,"G7MHX1","GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:0005615; GO:0005634","GO:0045296; GO:0042802; GO:0051219; GO:0005515; GO:0019901; GO:0008426","GO:0061436; GO:0008630; GO:0031424; GO:0003334; GO:0030216; GO:0043616; GO:0043154; GO:0010839; GO:0006469; GO:2000647; GO:0030307; GO:0045606; GO:0046827; GO:0051726; GO:0000079; GO:0010482; GO:0001836; GO:0007165; GO:0043588; GO:0072089","PTHR18860:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10773|UniProtKB=P31947","P00059; P00021; P00049; P00018"]
["14-3-3 zeta delta",null,"YWHAZ","28","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2116",".ANG., .APO., .CANCER., .CCP., .CCY., .CD., .CSP., .DEV., .DI., .EGFR., .FGFR., .HEPB., .HIPPO., .MAPK., .OP., .OPA., .OT., .PARK., .PI3K., .RTK., .ST., .TRASR.","FGF signaling pathway; Parkinson disease; EGF receptor signaling pathway; PI3 kinase pathway","14-3-3 PROTEIN ZETA/DELTA","angiogenesis; ERK1 and ERK2 cascade; establishment of Golgi localization; Golgi reassembly; lung development; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; protein phosphorylation; protein targeting; regulation of cell death; regulation of ERK1 and ERK2 cascade; regulation of synapse maturation; respiratory system process; signal transduction; synaptic target recognition; tube formation","cadherin binding; DNA-binding transcription factor binding; identical protein binding; phosphoserine residue binding; protein binding; protein domain specific binding; protein kinase binding; protein sequestering activity; RNA binding; transmembrane transporter binding; ubiquitin protein ligase binding","blood microparticle; cytoplasm; cytosol; extracellular exosome; extracellular space; focal adhesion; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; melanosome; nucleoplasm; nucleus; vesicle","Tyrosine kinase / adaptor","tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta","http://www.ncbi.nlm.nih.gov/gene/?term=7534","7534","22631","25578","475864",null,"709723","P63104","P63101","P63102","A0A8I3Q1P7","A0A287A0Q6","F7HBD4","GO:0072562; GO:0005737; GO:0005829; GO:0070062; GO:0005615; GO:0005925; GO:0098978; GO:0098686; GO:0042470; GO:0005654; GO:0005634; GO:0031982","GO:0045296; GO:0140297; GO:0042802; GO:0050815; GO:0005515; GO:0019904; GO:0019901; GO:0140311; GO:0003723; GO:0044325; GO:0031625","GO:0001525; GO:0070371; GO:0051683; GO:0090168; GO:0030324; GO:0043066; GO:0000122; GO:0006468; GO:0006605; GO:0010941; GO:0070372; GO:0090128; GO:0003016; GO:0007165; GO:0008039; GO:0035148","PTHR18860:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12855|UniProtKB=P63104","P00021; P00049; P00018; P00048"]
["4E-BP1",null,"EIF4EBP1","13","rb",null,1,1,1,1,1,1,"# 1965",".AML., .AMPK., .CANCER., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .P53S., .PI3K., .RTK., .SREME., .TRASR.","CCKR signaling map; p38 MAPK pathway; p53 pathway by glucose deprivation","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1","G1/S transition of mitotic cell cycle; negative regulation of translation; negative regulation of translational initiation; positive regulation of mitotic cell cycle; regulation of translation; TOR signaling","eukaryotic initiation factor 4E binding; protein binding; translation repressor activity","cytoplasm; cytosol","Metabolism / translational control","eukaryotic translation initiation factor 4E binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=1978","1978","13685","116636",null,null,null,"Q13541","Q60876","Q62622","A0A8I3NQD8","A0A5G2R886",null,"GO:0005737; GO:0005829","GO:0008190; GO:0005515; GO:0030371","GO:0000082; GO:0017148; GO:0045947; GO:0045931; GO:0006417; GO:0031929","PTHR12669:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3288|UniProtKB=Q13541","P06959; P05918; P04397"]
["4E-BP1 - phospho","Ser65","EIF4EBP1","20-15","rb",null,2,2,8,8,8,8,"# 1202",".AML., .AMPK., .CANCER., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D200., .D300., .DMTOR., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .P53S., .PI3K., .RTK., .SREME., .TRASR.","CCKR signaling map; p38 MAPK pathway; p53 pathway by glucose deprivation","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1","G1/S transition of mitotic cell cycle; negative regulation of translation; negative regulation of translational initiation; positive regulation of mitotic cell cycle; regulation of translation; TOR signaling","eukaryotic initiation factor 4E binding; protein binding; translation repressor activity","cytoplasm; cytosol","Metabolism / translational control","eukaryotic translation initiation factor 4E binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=1978","1978","13685","116636",null,null,null,"Q13541","Q60876","Q62622","A0A8I3NQD8","A0A5G2R886",null,"GO:0005737; GO:0005829","GO:0008190; GO:0005515; GO:0030371","GO:0000082; GO:0017148; GO:0045947; GO:0045931; GO:0006417; GO:0031929","PTHR12669:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3288|UniProtKB=Q13541","P06959; P05918; P04397"]
["4E-BP1 - phospho","Thr37/Thr46","EIF4EBP1","20-15","rb",null,2,2,8,8,8.1,8.1,"# 3038",".AML., .AMPK., .CANCER., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .P53S., .PI3K., .RTK., .SREME., .TRASR.","CCKR signaling map; p38 MAPK pathway; p53 pathway by glucose deprivation","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1","G1/S transition of mitotic cell cycle; negative regulation of translation; negative regulation of translational initiation; positive regulation of mitotic cell cycle; regulation of translation; TOR signaling","eukaryotic initiation factor 4E binding; protein binding; translation repressor activity","cytoplasm; cytosol","Metabolism / translational control","eukaryotic translation initiation factor 4E binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=1978","1978","13685","116636",null,null,null,"Q13541","Q60876","Q62622","A0A8I3NQD8","A0A5G2R886",null,"GO:0005737; GO:0005829","GO:0008190; GO:0005515; GO:0030371","GO:0000082; GO:0017148; GO:0045947; GO:0045931; GO:0006417; GO:0031929","PTHR12669:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3288|UniProtKB=Q13541","P06959; P05918; P04397"]
["4E-BP1 - phospho","Thr70","EIF4EBP1","20-15","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2345",".AML., .AMPK., .CANCER., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .P53S., .PI3K., .RTK., .SREME., .TRASR.","CCKR signaling map; p38 MAPK pathway; p53 pathway by glucose deprivation","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1","G1/S transition of mitotic cell cycle; negative regulation of translation; negative regulation of translational initiation; positive regulation of mitotic cell cycle; regulation of translation; TOR signaling","eukaryotic initiation factor 4E binding; protein binding; translation repressor activity","cytoplasm; cytosol",null,"eukaryotic translation initiation factor 4E binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=1978","1978","13685","116636",null,null,null,"Q13541","Q60876","Q62622","A0A8I3NQD8","A0A5G2R886",null,"GO:0005737; GO:0005829","GO:0008190; GO:0005515; GO:0030371","GO:0000082; GO:0017148; GO:0045947; GO:0045931; GO:0006417; GO:0031929","PTHR12669:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3288|UniProtKB=Q13541","P06959; P05918; P04397"]
["53BP1",null,"TP53BP1","450","rb",null,1,7,7,8,7,7,"# 1525",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .OP., .OT., .TRASR.",null,"TP53-BINDING PROTEIN 1","cellular response to DNA damage stimulus; cellular response to X-ray; DNA damage checkpoint signaling; DNA repair; DNA-templated transcription; double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of isotype switching; positive regulation of transcription by RNA polymerase II; protein homooligomerization","damaged DNA binding; DNA binding; histone binding; methylated histone binding; p53 binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; telomeric DNA binding; transcription coregulator activity; ubiquitin modification-dependent histone binding","chromosome; chromosome, centromeric region; chromosome, telomeric region; cytoplasm; DNA repair complex; kinetochore; nuclear body; nucleoplasm; nucleus; replication fork; site of double-strand break","DNA damage","tumor protein p53 binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=7158","7158","27223",null,null,null,null,"Q12888","P70399","A0A8I6AB98","A0A8I3PVG0",null,"A0A1D5RCN7","GO:0005694; GO:0000775; GO:0000781; GO:0005737; GO:1990391; GO:0000776; GO:0016604; GO:0005654; GO:0005634; GO:0005657; GO:0035861","GO:0003684; GO:0003677; GO:0042393; GO:0035064; GO:0002039; GO:0005515; GO:0061629; GO:0043565; GO:0042162; GO:0003712; GO:0061649","GO:0006974; GO:0071481; GO:0000077; GO:0006281; GO:0006351; GO:0006303; GO:2000042; GO:0051091; GO:0045893; GO:0045830; GO:0045944; GO:0051260","PTHR15321:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11999|UniProtKB=Q12888"]
["53BP1 - phospho","Ser1618","TP53BP1","450","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1535",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .OP., .OT., .TRASR.",null,"TP53-BINDING PROTEIN 1","cellular response to DNA damage stimulus; cellular response to X-ray; DNA damage checkpoint signaling; DNA repair; DNA-templated transcription; double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of isotype switching; positive regulation of transcription by RNA polymerase II; protein homooligomerization","damaged DNA binding; DNA binding; histone binding; methylated histone binding; p53 binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; telomeric DNA binding; transcription coregulator activity; ubiquitin modification-dependent histone binding","chromosome; chromosome, centromeric region; chromosome, telomeric region; cytoplasm; DNA repair complex; kinetochore; nuclear body; nucleoplasm; nucleus; replication fork; site of double-strand break","DNA damage","tumor protein p53 binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=7158","7158","27223",null,null,null,null,"Q12888","P70399","A0A8I6AB98","A0A8I3PVG0",null,"A0A1D5RCN7","GO:0005694; GO:0000775; GO:0000781; GO:0005737; GO:1990391; GO:0000776; GO:0016604; GO:0005654; GO:0005634; GO:0005657; GO:0035861","GO:0003684; GO:0003677; GO:0042393; GO:0035064; GO:0002039; GO:0005515; GO:0061629; GO:0043565; GO:0042162; GO:0003712; GO:0061649","GO:0006974; GO:0071481; GO:0000077; GO:0006281; GO:0006351; GO:0006303; GO:2000042; GO:0051091; GO:0045893; GO:0045830; GO:0045944; GO:0051260","PTHR15321:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11999|UniProtKB=Q12888"]
["53BP1 - phospho","Ser1778","TP53BP1","450","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1486",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .OP., .OT., .TRASR.",null,"TP53-BINDING PROTEIN 1","cellular response to DNA damage stimulus; cellular response to X-ray; DNA damage checkpoint signaling; DNA repair; DNA-templated transcription; double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of isotype switching; positive regulation of transcription by RNA polymerase II; protein homooligomerization","damaged DNA binding; DNA binding; histone binding; methylated histone binding; p53 binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; telomeric DNA binding; transcription coregulator activity; ubiquitin modification-dependent histone binding","chromosome; chromosome, centromeric region; chromosome, telomeric region; cytoplasm; DNA repair complex; kinetochore; nuclear body; nucleoplasm; nucleus; replication fork; site of double-strand break","DNA damage","tumor protein p53 binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=7158","7158","27223",null,null,null,null,"Q12888","P70399","A0A8I6AB98","A0A8I3PVG0",null,"A0A1D5RCN7","GO:0005694; GO:0000775; GO:0000781; GO:0005737; GO:1990391; GO:0000776; GO:0016604; GO:0005654; GO:0005634; GO:0005657; GO:0035861","GO:0003684; GO:0003677; GO:0042393; GO:0035064; GO:0002039; GO:0005515; GO:0061629; GO:0043565; GO:0042162; GO:0003712; GO:0061649","GO:0006974; GO:0071481; GO:0000077; GO:0006281; GO:0006351; GO:0006303; GO:2000042; GO:0051091; GO:0045893; GO:0045830; GO:0045944; GO:0051260","PTHR15321:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11999|UniProtKB=Q12888"]
["53BP1 - phospho","Ser25/Ser29","TP53BP1","450","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1485",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .OP., .OT., .TRASR.",null,"TP53-BINDING PROTEIN 1","cellular response to DNA damage stimulus; cellular response to X-ray; DNA damage checkpoint signaling; DNA repair; DNA-templated transcription; double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of isotype switching; positive regulation of transcription by RNA polymerase II; protein homooligomerization","damaged DNA binding; DNA binding; histone binding; methylated histone binding; p53 binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; telomeric DNA binding; transcription coregulator activity; ubiquitin modification-dependent histone binding","chromosome; chromosome, centromeric region; chromosome, telomeric region; cytoplasm; DNA repair complex; kinetochore; nuclear body; nucleoplasm; nucleus; replication fork; site of double-strand break","DNA damage","tumor protein p53 binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=7158","7158","27223",null,null,null,null,"Q12888","P70399","A0A8I6AB98","A0A8I3PVG0",null,"A0A1D5RCN7","GO:0005694; GO:0000775; GO:0000781; GO:0005737; GO:1990391; GO:0000776; GO:0016604; GO:0005654; GO:0005634; GO:0005657; GO:0035861","GO:0003684; GO:0003677; GO:0042393; GO:0035064; GO:0002039; GO:0005515; GO:0061629; GO:0043565; GO:0042162; GO:0003712; GO:0061649","GO:0006974; GO:0071481; GO:0000077; GO:0006281; GO:0006351; GO:0006303; GO:2000042; GO:0051091; GO:0045893; GO:0045830; GO:0045944; GO:0051260","PTHR15321:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11999|UniProtKB=Q12888"]
["53BP1 - phospho","Thr543","TP53BP1","450","rb",null,1,4,4,4,4,4,"# 1497",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .OP., .OT., .TRASR.",null,"TP53-BINDING PROTEIN 1","cellular response to DNA damage stimulus; cellular response to X-ray; DNA damage checkpoint signaling; DNA repair; DNA-templated transcription; double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of isotype switching; positive regulation of transcription by RNA polymerase II; protein homooligomerization","damaged DNA binding; DNA binding; histone binding; methylated histone binding; p53 binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; telomeric DNA binding; transcription coregulator activity; ubiquitin modification-dependent histone binding","chromosome; chromosome, centromeric region; chromosome, telomeric region; cytoplasm; DNA repair complex; kinetochore; nuclear body; nucleoplasm; nucleus; replication fork; site of double-strand break","DNA damage","tumor protein p53 binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=7158","7158","27223",null,null,null,null,"Q12888","P70399","A0A8I6AB98","A0A8I3PVG0",null,"A0A1D5RCN7","GO:0005694; GO:0000775; GO:0000781; GO:0005737; GO:1990391; GO:0000776; GO:0016604; GO:0005654; GO:0005634; GO:0005657; GO:0035861","GO:0003684; GO:0003677; GO:0042393; GO:0035064; GO:0002039; GO:0005515; GO:0061629; GO:0043565; GO:0042162; GO:0003712; GO:0061649","GO:0006974; GO:0071481; GO:0000077; GO:0006281; GO:0006351; GO:0006303; GO:2000042; GO:0051091; GO:0045893; GO:0045830; GO:0045944; GO:0051260","PTHR15321:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11999|UniProtKB=Q12888"]
["ABCG2 (BCRP)",null,"ABCG2","80-65","rb",null,2,6,7,7,1,2.1,"# 1519",".DRR., .OP., .OT.",null,"BROAD SUBSTRATE SPECIFICITY ATP-BINDING CASSETTE TRANSPORTER ABCG2","biotin transport; cellular detoxification; export across plasma membrane; lipid transport; organic anion transport; renal urate salt excretion; riboflavin transport; transepithelial transport; transmembrane transport; transport across blood-brain barrier; urate metabolic process; urate transport; xenobiotic transport across blood-brain barrier","ABC-type transporter activity; ABC-type xenobiotic transporter activity; ATP binding; ATPase-coupled transmembrane transporter activity; biotin transmembrane transporter activity; efflux transmembrane transporter activity; identical protein binding; nucleotide binding; organic anion transmembrane transporter activity; protein binding; protein dimerization activity; protein homodimerization activity; riboflavin transmembrane transporter activity; urate transmembrane transporter activity; xenobiotic transmembrane transporter activity","apical plasma membrane; brush border membrane; external side of apical plasma membrane; membrane; membrane raft; mitochondrial membrane; mitochondrion; nucleoplasm; plasma membrane","Metabolism","ATP binding cassette subfamily G member 2 (Junior blood group)","http://www.ncbi.nlm.nih.gov/gene/?term=9429","9429","27405","312382",null,null,null,"Q9UNQ0","Q99P81","Q80W57","A0A8I3NQE3","A0A5S6GWJ4","A0A5F7ZGF0","GO:0016324; GO:0031526; GO:0098591; GO:0016020; GO:0045121; GO:0031966; GO:0005739; GO:0005654; GO:0005886","GO:0140359; GO:0008559; GO:0005524; GO:0042626; GO:0015225; GO:0015562; GO:0042802; GO:0000166; GO:0008514; GO:0005515; GO:0046983; GO:0042803; GO:0032217; GO:0015143; GO:0042910","GO:0015878; GO:1990748; GO:0140115; GO:0006869; GO:0015711; GO:0097744; GO:0032218; GO:0070633; GO:0055085; GO:0150104; GO:0046415; GO:0015747; GO:1990962","PTHR48041:SF92","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=74|UniProtKB=Q9UNQ0"]
["ABCG5 (ATP Binding Cassette subfamily G, member 5)",null,"ABCG5","73","rb",null,2,7,7,7,2,7,"# 0717",".CSP., .DRR., .OP., .OPA., .OT., .ST.",null,"ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5","bile acid signaling pathway; cholesterol efflux; cholesterol homeostasis; intermembrane lipid transfer; intestinal cholesterol absorption; lipid transport; negative regulation of intestinal cholesterol absorption; negative regulation of intestinal phytosterol absorption; response to ionizing radiation; response to muscle activity; response to nutrient; response to nutrient levels; response to xenobiotic stimulus; sterol transport; transmembrane transport; triglyceride homeostasis","ABC-type transporter activity; ATP binding; ATP hydrolysis activity; ATPase-coupled transmembrane transporter activity; cholesterol transfer activity; metal ion binding; nucleotide binding; protein binding; protein dimerization activity; protein heterodimerization activity","apical part of cell; apical plasma membrane; ATP-binding cassette (ABC) transporter complex; membrane; plasma membrane; receptor complex","Metabolism","ATP binding cassette subfamily G member 5","http://www.ncbi.nlm.nih.gov/gene/?term=64240","64240","27409","114628",null,null,null,"Q9H222","Q99PE8","Q99PE7","A0A8I3PS59",null,"F7H0Y3","GO:0045177; GO:0016324; GO:0043190; GO:0016020; GO:0005886; GO:0043235","GO:0140359; GO:0005524; GO:0016887; GO:0042626; GO:0120020; GO:0046872; GO:0000166; GO:0005515; GO:0046983; GO:0046982","GO:0038183; GO:0033344; GO:0042632; GO:0120009; GO:0030299; GO:0006869; GO:0045796; GO:0010949; GO:0010212; GO:0014850; GO:0007584; GO:0031667; GO:0009410; GO:0015918; GO:0055085; GO:0070328","PTHR48041:SF113","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13886|UniProtKB=Q9H222"]
["ABL2",null,"ABL2","128","rb",null,2,6,4,7,4,6,"# 1343",".APH., .CD., .CSP., .EGFR., .OPA., .RAS., .RTK., .ST.",null,"TYROSINE-PROTEIN KINASE ABL2","cell adhesion; cell communication; cellular response to retinoic acid; exploration behavior; negative regulation of Rho protein signal transduction; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cytosolic calcium ion concentration; positive regulation of establishment of T cell polarity; positive regulation of neuron projection development; positive regulation of oxidoreductase activity; positive regulation of phospholipase C activity; positive regulation of T cell migration; protein modification process; protein phosphorylation; regulation of actin cytoskeleton reorganization; regulation of autophagy; regulation of cell adhesion; regulation of cell motility; regulation of endocytosis; signal transduction; signaling","actin filament binding; actin monomer binding; ATP binding; kinase activity; magnesium ion binding; manganese ion binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity","actin cytoskeleton; cytoplasm; cytoskeleton; cytosol",null,"ABL proto-oncogene 2, non-receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=27","27",null,"304883",null,"100627019","717037","P42684","A0A087WQB7","A0A8I5ZXU9","A0A8I3MZ44","A0A286ZN83","F7AU70","GO:0015629; GO:0005737; GO:0005856; GO:0005829","GO:0051015; GO:0003785; GO:0005524; GO:0016301; GO:0000287; GO:0030145; GO:0046872; GO:0004715; GO:0000166; GO:0001784; GO:0005515; GO:0004672; GO:0004713; GO:0016740","GO:0007155; GO:0007154; GO:0071300; GO:0035640; GO:0035024; GO:0018108; GO:0016310; GO:0007204; GO:1903905; GO:0010976; GO:0051353; GO:0010863; GO:2000406; GO:0036211; GO:0006468; GO:2000249; GO:0010506; GO:0030155; GO:2000145; GO:0030100; GO:0007165; GO:0023052","PTHR24418:SF87","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=77|UniProtKB=P42684"]
["Acetyl-CoA carboxylase - phospho","Ser79","ACACA","280","rb",null,2,2,1,2,2.1,2,"# 1216",".AMPK., .CD., .CSP., .DI., .HUNT., .INS., .OP., .P53S., .SREME.","p53 pathway; Huntington disease","ACETYL-COA CARBOXYLASE 1","acetyl-CoA metabolic process; cellular response to prostaglandin E stimulus; fatty acid biosynthetic process; fatty acid metabolic process; fatty-acyl-CoA biosynthetic process; lipid homeostasis; lipid metabolic process; malonyl-CoA biosynthetic process; metabolic process; protein homotetramerization; protein metabolic process; small molecule metabolic process; tissue homeostasis","acetyl-CoA carboxylase activity; ATP binding; catalytic activity; identical protein binding; ligase activity; metal ion binding; nucleotide binding; protein binding","actin cytoskeleton; cytoplasm; cytosol; fibrillar center; mitochondrion","Fatty acid biosynthesis","acetyl-CoA carboxylase alpha","http://www.ncbi.nlm.nih.gov/gene/?term=31","31","107476",null,"491130",null,null,"Q13085","Q5SWU9","A0A0G2K5G8","A0A8I3N1U4","A0A286ZJQ5","F7HHF7","GO:0015629; GO:0005737; GO:0005829; GO:0001650; GO:0005739","GO:0003989; GO:0005524; GO:0003824; GO:0042802; GO:0016874; GO:0046872; GO:0000166; GO:0005515","GO:0006084; GO:0071380; GO:0006633; GO:0006631; GO:0046949; GO:0055088; GO:0006629; GO:2001295; GO:0008152; GO:0051289; GO:0019538; GO:0044281; GO:0001894","PTHR45728:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=84|UniProtKB=Q13085","P00059; P00029"]
["Ack1",null,"TNK2","115","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1559",".CSP., .IIR., .IMUR., .OP., .OPA., .ST.",null,"ACTIVATED CDC42 KINASE 1","cell differentiation; cell surface receptor signaling pathway; endocytosis; innate immune response; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; protein phosphorylation; regulation of clathrin-dependent endocytosis; signal transduction; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; epidermal growth factor receptor binding; GTPase inhibitor activity; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity; ubiquitin protein ligase binding; WW domain binding","adherens junction; anchoring junction; clathrin-coated pit; clathrin-coated vesicle; cytoophidium; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; endosome; extrinsic component of cytoplasmic side of plasma membrane; Grb2-EGFR complex; intracellular membrane-bounded organelle; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane","Tyrosine kinase / adaptor","tyrosine kinase non receptor 2","http://www.ncbi.nlm.nih.gov/gene/?term=10188","10188","51789","303882",null,null,null,"Q07912","A0A0R4J1L0","A0A0G2JYY3","A0A8P0NXH2","A0A286ZT97","A0A5F7ZPT5","GO:0005912; GO:0070161; GO:0005905; GO:0030136; GO:0097268; GO:0005737; GO:0031410; GO:0030659; GO:0005829; GO:0005768; GO:0031234; GO:0070436; GO:0043231; GO:0016020; GO:0005634; GO:0048471; GO:0005886","GO:0005524; GO:0005154; GO:0005095; GO:0042802; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0004713; GO:0005102; GO:0016740; GO:0031625; GO:0050699","GO:0030154; GO:0007166; GO:0006897; GO:0045087; GO:0018108; GO:0016310; GO:0050731; GO:0006468; GO:2000369; GO:0007165; GO:0007264; GO:0007169","PTHR24418:SF379","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=19297|UniProtKB=Q07912"]
["Ack1 - phospho","Tyr284","TNK2","135","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1494",".CSP., .IIR., .IMUR., .OP., .OPA., .ST.",null,"ACTIVATED CDC42 KINASE 1","cell differentiation; cell surface receptor signaling pathway; endocytosis; innate immune response; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; protein phosphorylation; regulation of clathrin-dependent endocytosis; signal transduction; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; epidermal growth factor receptor binding; GTPase inhibitor activity; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity; ubiquitin protein ligase binding; WW domain binding","adherens junction; anchoring junction; clathrin-coated pit; clathrin-coated vesicle; cytoophidium; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; endosome; extrinsic component of cytoplasmic side of plasma membrane; Grb2-EGFR complex; intracellular membrane-bounded organelle; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane","Tyrosine kinase / adaptor","tyrosine kinase non receptor 2","http://www.ncbi.nlm.nih.gov/gene/?term=10188","10188","51789","303882",null,null,null,"Q07912","A0A0R4J1L0","A0A0G2JYY3","A0A8P0NXH2","A0A286ZT97","A0A5F7ZPT5","GO:0005912; GO:0070161; GO:0005905; GO:0030136; GO:0097268; GO:0005737; GO:0031410; GO:0030659; GO:0005829; GO:0005768; GO:0031234; GO:0070436; GO:0043231; GO:0016020; GO:0005634; GO:0048471; GO:0005886","GO:0005524; GO:0005154; GO:0005095; GO:0042802; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0004713; GO:0005102; GO:0016740; GO:0031625; GO:0050699","GO:0030154; GO:0007166; GO:0006897; GO:0045087; GO:0018108; GO:0016310; GO:0050731; GO:0006468; GO:2000369; GO:0007165; GO:0007264; GO:0007169","PTHR24418:SF379","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=19297|UniProtKB=Q07912"]
["ACOT13",null,"ACOT13","15","rb",null,1,1,"n/a","n/a","n/a","n/a","# 1669",null,null,"ACYL-COENZYME A THIOESTERASE 13","lipid metabolic process; negative regulation of cold-induced thermogenesis; protein homotetramerization","acyl-CoA hydrolase activity; hydrolase activity; metal ion binding; myristoyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity; protein binding","cytoplasm; cytoskeleton; cytosol; mitochondrial matrix; mitochondrion; nucleus; spindle",null,"acyl-CoA thioesterase 13","http://www.ncbi.nlm.nih.gov/gene/?term=55856","55856","66834","291135","610883",null,null,"Q9NPJ3","Q9CQR4","D3ZA93","A0A8I3P1B5",null,"F6PMY5","GO:0005737; GO:0005856; GO:0005829; GO:0005759; GO:0005739; GO:0005634; GO:0005819","GO:0047617; GO:0016787; GO:0046872; GO:0102991; GO:0016290; GO:0005515","GO:0006629; GO:0120163; GO:0051289","PTHR21660:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20999|UniProtKB=Q9NPJ3"]
["ACOT4",null,"ACOT4","46","rb",null,2,3,"n/a","n/a","n/a","n/a","# 1660",null,null,"PEROXISOMAL SUCCINYL-COENZYME A THIOESTERASE","acyl-CoA metabolic process; butyrate metabolic process; dicarboxylic acid catabolic process; dicarboxylic acid metabolic process; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; long-chain fatty acid metabolic process; saturated monocarboxylic acid metabolic process; short-chain fatty acid metabolic process; succinyl-CoA metabolic process; unsaturated monocarboxylic acid metabolic process; very long-chain fatty acid metabolic process","acyl-CoA hydrolase activity; glutaryl-CoA hydrolase activity; hydrolase activity; myristoyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity; succinyl-CoA hydrolase activity; thiolester hydrolase activity","cytoplasm; cytosol; peroxisomal matrix; peroxisome",null,"acyl-CoA thioesterase 4","http://www.ncbi.nlm.nih.gov/gene/?term=122970","122970","171282","681337",null,null,null,"Q8N9L9","Q8BWN8","D3ZIQ1",null,"A0A287B5Z7",null,"GO:0005737; GO:0005829; GO:0005782; GO:0005777","GO:0047617; GO:0044466; GO:0016787; GO:0102991; GO:0016290; GO:0004778; GO:0016790","GO:0006637; GO:0019605; GO:0043649; GO:0043648; GO:0006633; GO:0006631; GO:0006629; GO:0001676; GO:0032788; GO:0046459; GO:0006104; GO:0032789; GO:0000038","PTHR10824:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=19748|UniProtKB=Q8N9L9"]
["ACOT8",null,"ACOT8","36","gt",null,1,4,"n/a","n/a","n/a","n/a","# 1658",null,null,"ACYL-COENZYME A THIOESTERASE 8","acyl-CoA metabolic process; alpha-linolenic acid metabolic process; bile acid biosynthetic process; dicarboxylic acid catabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid catabolic process; fatty acid metabolic process; lipid metabolic process; negative regulation of CD4 production; peroxisome fission; peroxisome organization","acetoacetyl-CoA hydrolase activity; acetyl-CoA hydrolase activity; acyl-CoA hydrolase activity; choloyl-CoA hydrolase activity; CoA hydrolase activity; glutaryl-CoA hydrolase activity; hydrolase activity; hydroxymethylglutaryl-CoA hydrolase activity; long-chain acyl-CoA hydrolase activity; medium-chain acyl-CoA hydrolase activity; myristoyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity; protein binding; succinyl-CoA hydrolase activity","cytosol; peroxisomal matrix; peroxisome",null,"acyl-CoA thioesterase 8","http://www.ncbi.nlm.nih.gov/gene/?term=10005","10005","170789",null,"485899","100157173","717238","O14734","P58137","A0A8I5Y0F4","A0A8I3NNU2","I3LA89","A0A5F7Z994","GO:0005829; GO:0005782; GO:0005777","GO:0047603; GO:0003986; GO:0047617; GO:0033882; GO:0016289; GO:0044466; GO:0016787; GO:0047994; GO:0052816; GO:0052815; GO:0102991; GO:0016290; GO:0005515; GO:0004778","GO:0006637; GO:0036109; GO:0006699; GO:0043649; GO:0033540; GO:0009062; GO:0006631; GO:0006629; GO:0045225; GO:0016559; GO:0007031","PTHR11066:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=15919|UniProtKB=O14734"]
["Actin",null,"ACTA1","42","rb",null,1,1,1,1,1,2,"# 1765",".ALZ., .CADH., .CSP., .DEV., .DI., .HUNT., .IMUF., .INFM., .INT., .OP., .OPA., .OT., .TRASR., .WNT.","Huntington disease; Nicotinic acetylcholine receptor signaling pathway; Alzheimer disease-presenilin pathway; Cytoskeletal regulation by Rho GTPase; Cadherin signaling pathway; Integrin signalling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","ACTIN, ALPHA SKELETAL MUSCLE","cellular response to organonitrogen compound; mesenchyme migration; muscle contraction; positive regulation of gene expression; response to extracellular stimulus; response to lithium ion; response to mechanical stimulus; response to steroid hormone; skeletal muscle fiber adaptation; skeletal muscle fiber development; skeletal muscle thin filament assembly","ADP binding; ATP binding; hydrolase activity; myosin binding; nucleotide binding; protein binding; structural constituent of cytoskeleton","actin cytoskeleton; actin filament; blood microparticle; cell body; cytoplasm; cytoskeleton; cytosol; dynactin complex; extracellular exosome; extracellular space; filopodium; lamellipodium; sarcomere; stress fiber; striated muscle thin filament","Cytoskeletal regulation / Adhesion","actin alpha 1, skeletal muscle","http://www.ncbi.nlm.nih.gov/gene/?term=58","58","11459","29437",null,"100154254","100426612","P68133","P68134","P68136","A0A8I3MIB4","P68137","F7HNV4","GO:0015629; GO:0005884; GO:0072562; GO:0044297; GO:0005737; GO:0005856; GO:0005829; GO:0005869; GO:0070062; GO:0005615; GO:0030175; GO:0030027; GO:0030017; GO:0001725; GO:0005865","GO:0043531; GO:0005524; GO:0016787; GO:0017022; GO:0000166; GO:0005515; GO:0005200","GO:0071417; GO:0090131; GO:0006936; GO:0010628; GO:0009991; GO:0010226; GO:0009612; GO:0048545; GO:0043503; GO:0048741; GO:0030240","PTHR11937:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=129|UniProtKB=P68133","P00029; P00044; P00004; P00016; P00012; P00034; P00031; P00057"]
["Actin",null,"ACTA1","45","gt",null,1,2,1,1,1,1,"# 0900",".ALZ., .CADH., .CSP., .DEV., .DI., .HUNT., .IMUF., .INFM., .INT., .OP., .OPA., .OT., .TRASR., .WNT.","Huntington disease; Nicotinic acetylcholine receptor signaling pathway; Alzheimer disease-presenilin pathway; Cytoskeletal regulation by Rho GTPase; Cadherin signaling pathway; Integrin signalling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","ACTIN, ALPHA SKELETAL MUSCLE","cellular response to organonitrogen compound; mesenchyme migration; muscle contraction; positive regulation of gene expression; response to extracellular stimulus; response to lithium ion; response to mechanical stimulus; response to steroid hormone; skeletal muscle fiber adaptation; skeletal muscle fiber development; skeletal muscle thin filament assembly","ADP binding; ATP binding; hydrolase activity; myosin binding; nucleotide binding; protein binding; structural constituent of cytoskeleton","actin cytoskeleton; actin filament; blood microparticle; cell body; cytoplasm; cytoskeleton; cytosol; dynactin complex; extracellular exosome; extracellular space; filopodium; lamellipodium; sarcomere; stress fiber; striated muscle thin filament","Cytoskeletal regulation / Adhesion","actin alpha 1, skeletal muscle","http://www.ncbi.nlm.nih.gov/gene/?term=58","58","11459","29437",null,"100154254","100426612","P68133","P68134","P68136","A0A8I3MIB4","P68137","F7HNV4","GO:0015629; GO:0005884; GO:0072562; GO:0044297; GO:0005737; GO:0005856; GO:0005829; GO:0005869; GO:0070062; GO:0005615; GO:0030175; GO:0030027; GO:0030017; GO:0001725; GO:0005865","GO:0043531; GO:0005524; GO:0016787; GO:0017022; GO:0000166; GO:0005515; GO:0005200","GO:0071417; GO:0090131; GO:0006936; GO:0010628; GO:0009991; GO:0010226; GO:0009612; GO:0048545; GO:0043503; GO:0048741; GO:0030240","PTHR11937:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=129|UniProtKB=P68133","P00029; P00044; P00004; P00016; P00012; P00034; P00031; P00057"]
["Actin",null,"ACTA1","42","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2257",".ALZ., .CADH., .CSP., .DEV., .DI., .HUNT., .IMUF., .INFM., .INT., .OP., .OPA., .OT., .TRASR., .WNT.","Huntington disease; Nicotinic acetylcholine receptor signaling pathway; Alzheimer disease-presenilin pathway; Cytoskeletal regulation by Rho GTPase; Cadherin signaling pathway; Integrin signalling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","ACTIN, ALPHA SKELETAL MUSCLE","cellular response to organonitrogen compound; mesenchyme migration; muscle contraction; positive regulation of gene expression; response to extracellular stimulus; response to lithium ion; response to mechanical stimulus; response to steroid hormone; skeletal muscle fiber adaptation; skeletal muscle fiber development; skeletal muscle thin filament assembly","ADP binding; ATP binding; hydrolase activity; myosin binding; nucleotide binding; protein binding; structural constituent of cytoskeleton","actin cytoskeleton; actin filament; blood microparticle; cell body; cytoplasm; cytoskeleton; cytosol; dynactin complex; extracellular exosome; extracellular space; filopodium; lamellipodium; sarcomere; stress fiber; striated muscle thin filament","Cytoskeletal regulation / Adhesion","actin alpha 1, skeletal muscle","http://www.ncbi.nlm.nih.gov/gene/?term=58","58","11459","29437",null,"100154254","100426612","P68133","P68134","P68136","A0A8I3MIB4","P68137","F7HNV4","GO:0015629; GO:0005884; GO:0072562; GO:0044297; GO:0005737; GO:0005856; GO:0005829; GO:0005869; GO:0070062; GO:0005615; GO:0030175; GO:0030027; GO:0030017; GO:0001725; GO:0005865","GO:0043531; GO:0005524; GO:0016787; GO:0017022; GO:0000166; GO:0005515; GO:0005200","GO:0071417; GO:0090131; GO:0006936; GO:0010628; GO:0009991; GO:0010226; GO:0009612; GO:0048545; GO:0043503; GO:0048741; GO:0030240","PTHR11937:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=129|UniProtKB=P68133","P00029; P00044; P00004; P00016; P00012; P00034; P00031; P00057"]
["ADAM12",null,"ADAM12","100","rb",null,7,2,6,6,7,7,"# 1387",".ANG., .CANCER., .OP.",null,"DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 12","cell adhesion; myoblast fusion; positive regulation of angiogenesis; proteolysis","hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; SH3 domain binding","extracellular region; membrane; nucleoplasm; plasma membrane","Cytoskeletal signaling","ADAM metallopeptidase domain 12","http://www.ncbi.nlm.nih.gov/gene/?term=8038","8038","11489","679837","100686018",null,null,"O43184","Q61824","A0A8I6AGQ6","A0A8I3PTF2","A0A287AH19","F6YJ38","GO:0005576; GO:0016020; GO:0005654; GO:0005886","GO:0016787; GO:0046872; GO:0004222; GO:0008237; GO:0008233; GO:0005515; GO:0017124","GO:0007155; GO:0007520; GO:0045766; GO:0006508","PTHR11905:SF112","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=190|UniProtKB=O43184"]
["Adam9",null,"ADAM9","115-100, 80-75","rb",null,1,2.1,1,7,1.1000000000000001,1,"# 1429",".ALZ., .CSP., .DEV., .DI., .INT., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .TGFB.","Alzheimer disease-amyloid secretase pathway","DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9","cell adhesion; cell adhesion mediated by integrin; cell migration; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cellular response to lipopolysaccharide; integrin-mediated signaling pathway; keratinocyte differentiation; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; monocyte activation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of keratinocyte migration; positive regulation of macrophage fusion; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein secretion; proteolysis; response to calcium ion; response to glucocorticoid; response to hydrogen peroxide; response to manganese ion; response to tumor necrosis factor; transforming growth factor beta receptor signaling pathway","collagen binding; hydrolase activity; integrin binding; laminin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; protein kinase C binding; SH3 domain binding","cell surface; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; focal adhesion; membrane; plasma membrane","Cytoskeletal signaling","ADAM metallopeptidase domain 9","http://www.ncbi.nlm.nih.gov/gene/?term=8754","8754","11502",null,null,null,null,"Q13443","Q61072","A0A8I5Y224","A0A8I3NHS9","A0A287AQW4","F6SG12","GO:0009986; GO:0009897; GO:0070062; GO:0005576; GO:0005615; GO:0005925; GO:0016020; GO:0005886","GO:0005518; GO:0016787; GO:0005178; GO:0043236; GO:0046872; GO:0004222; GO:0008237; GO:0008233; GO:0005515; GO:0005080; GO:0017124","GO:0007155; GO:0033627; GO:0016477; GO:0033631; GO:0007160; GO:0071222; GO:0007229; GO:0030216; GO:0006509; GO:0031293; GO:0042117; GO:0033630; GO:0030335; GO:0051549; GO:0034241; GO:0043406; GO:0051044; GO:0050714; GO:0006508; GO:0051592; GO:0051384; GO:0042542; GO:0010042; GO:0034612; GO:0007179","PTHR11905:SF136","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=216|UniProtKB=Q13443","P00003"]
["ADAMTS1",null,"ADAMTS1","110","rb",null,2,4,8,8,4,4,"# 1463",".ANG., .CANCER., .CCP., .CCY., .CP., .CSP., .INT., .OP., .OPA.",null,"A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 1","extracellular matrix organization; heart trabecula formation; integrin-mediated signaling pathway; kidney development; negative regulation of angiogenesis; negative regulation of cell population proliferation; ovulation from ovarian follicle; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; proteolysis","heparin binding; hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding","basement membrane; collagen-containing extracellular matrix; cytoplasmic vesicle; extracellular matrix; extracellular region","Cytoskeletal signaling","ADAM metallopeptidase with thrombospondin type 1 motif 1","http://www.ncbi.nlm.nih.gov/gene/?term=9510","9510","11504","79252",null,null,null,"Q9UHI8","P97857","Q68EJ2","A0A8P0SDQ1","A0A5G2R7E9",null,"GO:0005604; GO:0062023; GO:0031410; GO:0031012; GO:0005576","GO:0008201; GO:0016787; GO:0046872; GO:0004222; GO:0008237; GO:0008233; GO:0005515; GO:0008270","GO:0030198; GO:0060347; GO:0007229; GO:0001822; GO:0016525; GO:0008285; GO:0001542; GO:1900087; GO:1904754; GO:1904707; GO:0006508","PTHR13723:SF40","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=217|UniProtKB=Q9UHI8"]
["Adipophilin",null,"PLIN2","48","ms",null,1,1.1000000000000001,1.1000000000000001,8,8,8,"# 0819",".DRR., .OP., .OT.",null,"PERILIPIN-2","cellular response to glucose starvation; lipid droplet disassembly; lipid storage; long-chain fatty acid transport; positive regulation of sequestering of triglyceride; response to organic cyclic compound; response to xenobiotic stimulus","protein binding","cytoplasm; cytosol; endoplasmic reticulum; extracellular region; lipid droplet; membrane; nucleus; plasma membrane",null,"perilipin 2","http://www.ncbi.nlm.nih.gov/gene/?term=123","123","11520","298199","100856329",null,null,"Q99541","P43883","A0A8I5ZQJ5","A0A8I3NVF1",null,"A0A5F7ZFD6","GO:0005737; GO:0005829; GO:0005783; GO:0005576; GO:0005811; GO:0016020; GO:0005634; GO:0005886","GO:0005515","GO:0042149; GO:1905691; GO:0019915; GO:0015909; GO:0010890; GO:0014070; GO:0009410","PTHR14024:SF25","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=248|UniProtKB=Q99541"]
["Afadin - phospho","Ser1718","AFDN","205","rb",null,2,4,4,4,7,7,"# 1532",".ALZ., .cAMP., .CSP., .DI., .GPCR., .MIG., .OP., .OPA., .OT., .RAS., .RTK., .ST., .TRASR.","Alzheimer disease-presenilin pathway","AFADIN","anatomical structure development; bicellular tight junction assembly; cell adhesion; cell differentiation; cell-cell adhesion mediated by cadherin; cell-cell signaling; establishment of endothelial intestinal barrier; establishment of protein localization to plasma membrane; negative regulation of cell migration; pore complex assembly; positive regulation of cell-cell adhesion; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of gene expression; positive regulation of GTPase activity; regulation of protein localization; signal transduction","actin filament binding; cadherin binding; cell adhesion molecule binding; protein binding; protein C-terminus binding; small GTPase binding","adherens junction; anchoring junction; cell junction; cell-cell contact zone; cell-cell junction; cytosol; nuclear speck; nucleoplasm; plasma membrane; pore complex; tight junction","Adhesion","afadin, adherens junction formation factor","http://www.ncbi.nlm.nih.gov/gene/?term=4301","4301","17356","26955",null,null,null,"P55196","Q9QZQ1","O35889","A0A8P0N422","A0A286ZM64","F7HG05","GO:0005912; GO:0070161; GO:0030054; GO:0044291; GO:0005911; GO:0005829; GO:0016607; GO:0005654; GO:0005886; GO:0046930; GO:0070160","GO:0051015; GO:0045296; GO:0050839; GO:0005515; GO:0008022; GO:0031267","GO:0048856; GO:0070830; GO:0007155; GO:0030154; GO:0044331; GO:0007267; GO:0090557; GO:0061951; GO:0030336; GO:0046931; GO:0022409; GO:2000049; GO:0010628; GO:0043547; GO:0032880; GO:0007165","PTHR10398:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7137|UniProtKB=P55196","P00004"]
["AFP",null,"AFP","70","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0873",".CSP., .DEV., .HIPPO., .TGFB.",null,"ALPHA-FETOPROTEIN","ovulation from ovarian follicle; progesterone metabolic process; sexual reproduction; SMAD protein signal transduction","fatty acid binding; metal ion binding; protein binding; zinc ion binding","cytoplasm; endoplasmic reticulum lumen; extracellular region; extracellular space","Wnt / hedgehog signaling / tumor marker","alpha fetoprotein","http://www.ncbi.nlm.nih.gov/gene/?term=174","174","11576","24177",null,"397586",null,"P02771","P02772","G3V6D0","A0A8I3MY51","Q8MJ76","A0A1D5QKX9","GO:0005737; GO:0005788; GO:0005576; GO:0005615","GO:0005504; GO:0046872; GO:0005515; GO:0008270","GO:0001542; GO:0042448; GO:0019953; GO:0060395","PTHR11385:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=317|UniProtKB=P02771"]
["AHR (aryl hydrocarbon receptor)",null,"AHR","96","sheep",null,6,2,6,6,7,7,"# 1100",".APO., .BCR., .cAMP., .CCP., .CCY., .CD., .CSP., .DRR., .GPCR., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .ST., .TCD., .TMAT., .TRASR.",null,"ARYL HYDROCARBON RECEPTOR","apoptotic process; blood vessel development; cAMP-mediated signaling; cell cycle; cellular response to 2,3,7,8-tetrachlorodibenzodioxine; cellular response to cAMP; cellular response to forskolin; circadian regulation of gene expression; intracellular receptor signaling pathway; negative regulation of DNA-templated transcription; negative regulation of T cell mediated immune response to tumor cell; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of adaptive immune response; regulation of B cell proliferation; regulation of DNA-templated transcription; regulation of gene expression; regulation of transcription by RNA polymerase II; response to toxic substance; response to xenobiotic stimulus; rhythmic process; xenobiotic metabolic process","cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; Hsp90 protein binding; molecular adaptor activity; nuclear receptor activity; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding; TBP-class protein binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; transcription coactivator binding","aryl hydrocarbon receptor complex; chromatin; cytoplasm; cytosol; cytosolic aryl hydrocarbon receptor complex; nuclear aryl hydrocarbon receptor complex; nucleoplasm; nucleus; protein-containing complex; transcription regulator complex","Transcription factor","aryl hydrocarbon receptor","http://www.ncbi.nlm.nih.gov/gene/?term=196","196",null,"25690","475251",null,"714254","P35869","A0A0B4J1L1","G3V6M2","A0A8I3RSX6","I3LF82","A0A5F7ZYZ8","GO:0034751; GO:0000785; GO:0005737; GO:0005829; GO:0034752; GO:0034753; GO:0005654; GO:0005634; GO:0032991; GO:0005667","GO:0000987; GO:0003677; GO:0003700; GO:0000981; GO:0070888; GO:0051879; GO:0060090; GO:0004879; GO:0005515; GO:0046983; GO:0046982; GO:0042803; GO:0061629; GO:1990837; GO:0017025; GO:0001094; GO:0000976; GO:0001223","GO:0006915; GO:0001568; GO:0019933; GO:0007049; GO:1904613; GO:0071320; GO:1904322; GO:0032922; GO:0030522; GO:0045892; GO:0002841; GO:0045893; GO:0045944; GO:0002819; GO:0030888; GO:0006355; GO:0010468; GO:0006357; GO:0009636; GO:0009410; GO:0048511; GO:0006805","PTHR10649:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=348|UniProtKB=P35869"]
["AIM2",null,"AIM2","40","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1664",".APO., .CD., .CSP., .DRR., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .NFKB., .OP., .OPA., .OT., .ST., .TNF., .TRASR., .VIR.",null,"INTERFERON-INDUCIBLE PROTEIN AIM2","activation of innate immune response; apoptotic process; cellular response to interferon-beta; cellular response to xenobiotic stimulus; defense response to virus; immune response; immune system process; inflammatory response; innate immune response; negative regulation of NF-kappaB transcription factor activity; NLRP3 inflammasome complex assembly; pattern recognition receptor signaling pathway; positive regulation of cysteine-type endopeptidase activity; positive regulation of defense response to virus by host; positive regulation of inflammatory response; positive regulation of interleukin-1 beta production; positive regulation of NF-kappaB transcription factor activity; pyroptosis; pyroptosome complex assembly; tumor necrosis factor-mediated signaling pathway","DNA binding; double-stranded DNA binding; identical protein binding; protein binding","AIM2 inflammasome complex; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus",null,"absent in melanoma 2","http://www.ncbi.nlm.nih.gov/gene/?term=9447","9447","383619","304987",null,null,null,"O14862","Q91VJ1","D4A9W0",null,null,"F7GG22","GO:0097169; GO:0005737; GO:0005829; GO:0005739; GO:0005654; GO:0005634","GO:0003677; GO:0003690; GO:0042802; GO:0005515","GO:0002218; GO:0006915; GO:0035458; GO:0071466; GO:0051607; GO:0006955; GO:0002376; GO:0006954; GO:0045087; GO:0032088; GO:0044546; GO:0002221; GO:2001056; GO:0002230; GO:0050729; GO:0032731; GO:0051092; GO:0070269; GO:1904270; GO:0033209","PTHR12200:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=357|UniProtKB=O14862"]
["Akt (pan)",null,"AKT1, AKT2, AKT3","60","rb",null,1,1,1,1,1,1,"# 3035",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway; PDGF signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE; RAC-BETA SERINE/THREONINE-PROTEIN KINASE; RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling; activation of GTPase activity; cellular response to high light intensity; fat cell differentiation; intracellular protein transmembrane transport; positive regulation of cell migration; positive regulation of cell motility; positive regulation of fatty acid beta-oxidation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein modification process; regulation of cell cycle; retinal rod cell apoptotic process; brain morphogenesis; homeostasis of number of cells within a tissue; mitochondrial genome maintenance; negative regulation of cellular senescence; positive regulation of angiogenesis; positive regulation of artery morphogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell size; positive regulation of TOR signaling; positive regulation of vascular endothelial cell proliferation","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity; metal ion binding; molecular function activator activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle; cell cortex; early endosome; endosome; intracellular membrane-bounded organelle; ruffle membrane","Akt signaling / metabolism","AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=207, http://www.ncbi.nlm.nih.gov/gene/?term=208, http://www.ncbi.nlm.nih.gov/gene/?term=10000","207, 208, 10000","11651, 11652, 23797",null,null,"NA, 100513811",null,"P31749, P31751, Q9Y243","P31750, Q60823, Q9WUA6","A0A8I5YBI2, A0A8I5Y943, A0A0G2JXD7","A0A8I3P9C5, A0A8I3MNQ3, A0A8I3MMB4","A0A287AQP0, A0A287AN96","A0A1D5RJS3, A0A1D5RH80, F6R8M1","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982; GO:0005938; GO:0005769; GO:0005768; GO:0043231; GO:0032587","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740; GO:0046872; GO:0140677","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929; GO:0090630; GO:0071486; GO:0045444; GO:0065002; GO:0030335; GO:2000147; GO:0032000; GO:0090314; GO:0031340; GO:0072659; GO:0036211; GO:0051726; GO:0097473; GO:0048854; GO:0048873; GO:0000002; GO:2000773; GO:0045766; GO:1905653; GO:0090050; GO:0045793; GO:0032008; GO:1905564","PTHR24356:SF171; PTHR24356:SF176; PTHR24356:SF190","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=392|UniProtKB=P31751; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=393|UniProtKB=Q9Y243","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006; P00047"]
["Akt (pan) - phospho","Ser473","AKT1, AKT2, AKT3","60","rb",null,1.1000000000000001,1.1000000000000001,8,8,1.1000000000000001,8,"# 2072",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway; PDGF signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE; RAC-BETA SERINE/THREONINE-PROTEIN KINASE; RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling; activation of GTPase activity; cellular response to high light intensity; fat cell differentiation; intracellular protein transmembrane transport; positive regulation of cell migration; positive regulation of cell motility; positive regulation of fatty acid beta-oxidation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein modification process; regulation of cell cycle; retinal rod cell apoptotic process; brain morphogenesis; homeostasis of number of cells within a tissue; mitochondrial genome maintenance; negative regulation of cellular senescence; positive regulation of angiogenesis; positive regulation of artery morphogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell size; positive regulation of TOR signaling; positive regulation of vascular endothelial cell proliferation","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity; metal ion binding; molecular function activator activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle; cell cortex; early endosome; endosome; intracellular membrane-bounded organelle; ruffle membrane","Akt signaling / metabolism","AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=207, http://www.ncbi.nlm.nih.gov/gene/?term=208, http://www.ncbi.nlm.nih.gov/gene/?term=10000","207, 208, 10000","11651, 11652, 23797",null,null,"NA, 100513811",null,"P31749, P31751, Q9Y243","P31750, Q60823, Q9WUA6","A0A8I5YBI2, A0A8I5Y943, A0A0G2JXD7","A0A8I3P9C5, A0A8I3MNQ3, A0A8I3MMB4","A0A287AQP0, A0A287AN96","A0A1D5RJS3, A0A1D5RH80, F6R8M1","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982; GO:0005938; GO:0005769; GO:0005768; GO:0043231; GO:0032587","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740; GO:0046872; GO:0140677","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929; GO:0090630; GO:0071486; GO:0045444; GO:0065002; GO:0030335; GO:2000147; GO:0032000; GO:0090314; GO:0031340; GO:0072659; GO:0036211; GO:0051726; GO:0097473; GO:0048854; GO:0048873; GO:0000002; GO:2000773; GO:0045766; GO:1905653; GO:0090050; GO:0045793; GO:0032008; GO:1905564","PTHR24356:SF171; PTHR24356:SF176; PTHR24356:SF190","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=392|UniProtKB=P31751; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=393|UniProtKB=Q9Y243","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006; P00047"]
["Akt (pan) - phospho","Thr308","AKT1, AKT2, AKT3","60","rb",null,7,4,4,4,4,4,"# 1771",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway; PDGF signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE; RAC-BETA SERINE/THREONINE-PROTEIN KINASE; RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling; activation of GTPase activity; cellular response to high light intensity; fat cell differentiation; intracellular protein transmembrane transport; positive regulation of cell migration; positive regulation of cell motility; positive regulation of fatty acid beta-oxidation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein modification process; regulation of cell cycle; retinal rod cell apoptotic process; brain morphogenesis; homeostasis of number of cells within a tissue; mitochondrial genome maintenance; negative regulation of cellular senescence; positive regulation of angiogenesis; positive regulation of artery morphogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell size; positive regulation of TOR signaling; positive regulation of vascular endothelial cell proliferation","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity; metal ion binding; molecular function activator activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle; cell cortex; early endosome; endosome; intracellular membrane-bounded organelle; ruffle membrane","Akt signaling / metabolism","AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=207, http://www.ncbi.nlm.nih.gov/gene/?term=208, http://www.ncbi.nlm.nih.gov/gene/?term=10000","207, 208, 10000","11651, 11652, 23797",null,null,"NA, 100513811",null,"P31749, P31751, Q9Y243","P31750, Q60823, Q9WUA6","A0A8I5YBI2, A0A8I5Y943, A0A0G2JXD7","A0A8I3P9C5, A0A8I3MNQ3, A0A8I3MMB4","A0A287AQP0, A0A287AN96","A0A1D5RJS3, A0A1D5RH80, F6R8M1","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982; GO:0005938; GO:0005769; GO:0005768; GO:0043231; GO:0032587","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740; GO:0046872; GO:0140677","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929; GO:0090630; GO:0071486; GO:0045444; GO:0065002; GO:0030335; GO:2000147; GO:0032000; GO:0090314; GO:0031340; GO:0072659; GO:0036211; GO:0051726; GO:0097473; GO:0048854; GO:0048873; GO:0000002; GO:2000773; GO:0045766; GO:1905653; GO:0090050; GO:0045793; GO:0032008; GO:1905564","PTHR24356:SF171; PTHR24356:SF176; PTHR24356:SF190","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=392|UniProtKB=P31751; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=393|UniProtKB=Q9Y243","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006; P00047"]
["Akt (pan) - phospho","Thr308","AKT1, AKT2, AKT3","60","rb",null,1.1000000000000001,4,4,4,4,4,"# 2404",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway; PDGF signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE; RAC-BETA SERINE/THREONINE-PROTEIN KINASE; RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling; activation of GTPase activity; cellular response to high light intensity; fat cell differentiation; intracellular protein transmembrane transport; positive regulation of cell migration; positive regulation of cell motility; positive regulation of fatty acid beta-oxidation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein modification process; regulation of cell cycle; retinal rod cell apoptotic process; brain morphogenesis; homeostasis of number of cells within a tissue; mitochondrial genome maintenance; negative regulation of cellular senescence; positive regulation of angiogenesis; positive regulation of artery morphogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell size; positive regulation of TOR signaling; positive regulation of vascular endothelial cell proliferation","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity; metal ion binding; molecular function activator activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle; cell cortex; early endosome; endosome; intracellular membrane-bounded organelle; ruffle membrane","Akt signaling / metabolism","AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=207, http://www.ncbi.nlm.nih.gov/gene/?term=208, http://www.ncbi.nlm.nih.gov/gene/?term=10000","207, 208, 10000","11651, 11652, 23797",null,null,"NA, 100513811",null,"P31749, P31751, Q9Y243","P31750, Q60823, Q9WUA6","A0A8I5YBI2, A0A8I5Y943, A0A0G2JXD7","A0A8I3P9C5, A0A8I3MNQ3, A0A8I3MMB4","A0A287AQP0, A0A287AN96","A0A1D5RJS3, A0A1D5RH80, F6R8M1","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982; GO:0005938; GO:0005769; GO:0005768; GO:0043231; GO:0032587","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740; GO:0046872; GO:0140677","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929; GO:0090630; GO:0071486; GO:0045444; GO:0065002; GO:0030335; GO:2000147; GO:0032000; GO:0090314; GO:0031340; GO:0072659; GO:0036211; GO:0051726; GO:0097473; GO:0048854; GO:0048873; GO:0000002; GO:2000773; GO:0045766; GO:1905653; GO:0090050; GO:0045793; GO:0032008; GO:1905564","PTHR24356:SF171; PTHR24356:SF176; PTHR24356:SF190","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=392|UniProtKB=P31751; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=393|UniProtKB=Q9Y243","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006; P00047"]
["Akt (pan) - phospho","Thr308","AKT1, AKT2, AKT3","60","rb",null,1,2,"n/a","n/a","n/a","n/a","# 2452",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway; PDGF signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE; RAC-BETA SERINE/THREONINE-PROTEIN KINASE; RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling; activation of GTPase activity; cellular response to high light intensity; fat cell differentiation; intracellular protein transmembrane transport; positive regulation of cell migration; positive regulation of cell motility; positive regulation of fatty acid beta-oxidation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein modification process; regulation of cell cycle; retinal rod cell apoptotic process; brain morphogenesis; homeostasis of number of cells within a tissue; mitochondrial genome maintenance; negative regulation of cellular senescence; positive regulation of angiogenesis; positive regulation of artery morphogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell size; positive regulation of TOR signaling; positive regulation of vascular endothelial cell proliferation","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity; metal ion binding; molecular function activator activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle; cell cortex; early endosome; endosome; intracellular membrane-bounded organelle; ruffle membrane","Akt signaling / metabolism","AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=207, http://www.ncbi.nlm.nih.gov/gene/?term=208, http://www.ncbi.nlm.nih.gov/gene/?term=10000","207, 208, 10000","11651, 11652, 23797",null,null,"NA, 100513811",null,"P31749, P31751, Q9Y243","P31750, Q60823, Q9WUA6","A0A8I5YBI2, A0A8I5Y943, A0A0G2JXD7","A0A8I3P9C5, A0A8I3MNQ3, A0A8I3MMB4","A0A287AQP0, A0A287AN96","A0A1D5RJS3, A0A1D5RH80, F6R8M1","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982; GO:0005938; GO:0005769; GO:0005768; GO:0043231; GO:0032587","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740; GO:0046872; GO:0140677","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929; GO:0090630; GO:0071486; GO:0045444; GO:0065002; GO:0030335; GO:2000147; GO:0032000; GO:0090314; GO:0031340; GO:0072659; GO:0036211; GO:0051726; GO:0097473; GO:0048854; GO:0048873; GO:0000002; GO:2000773; GO:0045766; GO:1905653; GO:0090050; GO:0045793; GO:0032008; GO:1905564","PTHR24356:SF171; PTHR24356:SF176; PTHR24356:SF190","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=392|UniProtKB=P31751; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=393|UniProtKB=Q9Y243","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006; P00047"]
["Akt (pan) - phospho","Thr450","AKT1, AKT2, AKT3","60","rb",null,2,2,"n/a","n/a","n/a","n/a","# 3065",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway; PDGF signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE; RAC-BETA SERINE/THREONINE-PROTEIN KINASE; RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling; activation of GTPase activity; cellular response to high light intensity; fat cell differentiation; intracellular protein transmembrane transport; positive regulation of cell migration; positive regulation of cell motility; positive regulation of fatty acid beta-oxidation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein modification process; regulation of cell cycle; retinal rod cell apoptotic process; brain morphogenesis; homeostasis of number of cells within a tissue; mitochondrial genome maintenance; negative regulation of cellular senescence; positive regulation of angiogenesis; positive regulation of artery morphogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell size; positive regulation of TOR signaling; positive regulation of vascular endothelial cell proliferation","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity; metal ion binding; molecular function activator activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle; cell cortex; early endosome; endosome; intracellular membrane-bounded organelle; ruffle membrane",null,"AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=207, http://www.ncbi.nlm.nih.gov/gene/?term=208, http://www.ncbi.nlm.nih.gov/gene/?term=10000","207, 208, 10000","11651, 11652, 23797",null,null,"NA, 100513811",null,"P31749, P31751, Q9Y243","P31750, Q60823, Q9WUA6","A0A8I5YBI2, A0A8I5Y943, A0A0G2JXD7","A0A8I3P9C5, A0A8I3MNQ3, A0A8I3MMB4","A0A287AQP0, A0A287AN96","A0A1D5RJS3, A0A1D5RH80, F6R8M1","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982; GO:0005938; GO:0005769; GO:0005768; GO:0043231; GO:0032587","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740; GO:0046872; GO:0140677","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929; GO:0090630; GO:0071486; GO:0045444; GO:0065002; GO:0030335; GO:2000147; GO:0032000; GO:0090314; GO:0031340; GO:0072659; GO:0036211; GO:0051726; GO:0097473; GO:0048854; GO:0048873; GO:0000002; GO:2000773; GO:0045766; GO:1905653; GO:0090050; GO:0045793; GO:0032008; GO:1905564","PTHR24356:SF171; PTHR24356:SF176; PTHR24356:SF190","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=392|UniProtKB=P31751; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=393|UniProtKB=Q9Y243","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006; P00047"]
["Akt (pan) substrates - phospho","Ser/Thr","AKT1, AKT2, AKT3","n.a.","rb",null,2,2,2,8,2.1,2.1,"# 1604",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway; PDGF signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE; RAC-BETA SERINE/THREONINE-PROTEIN KINASE; RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling; activation of GTPase activity; cellular response to high light intensity; fat cell differentiation; intracellular protein transmembrane transport; positive regulation of cell migration; positive regulation of cell motility; positive regulation of fatty acid beta-oxidation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein modification process; regulation of cell cycle; retinal rod cell apoptotic process; brain morphogenesis; homeostasis of number of cells within a tissue; mitochondrial genome maintenance; negative regulation of cellular senescence; positive regulation of angiogenesis; positive regulation of artery morphogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell size; positive regulation of TOR signaling; positive regulation of vascular endothelial cell proliferation","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity; metal ion binding; molecular function activator activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle; cell cortex; early endosome; endosome; intracellular membrane-bounded organelle; ruffle membrane","Akt signaling / metabolism","AKT serine/threonine kinase 1; AKT serine/threonine kinase 2; AKT serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=207, http://www.ncbi.nlm.nih.gov/gene/?term=208, http://www.ncbi.nlm.nih.gov/gene/?term=10000","207, 208, 10000","11651, 11652, 23797",null,null,"NA, 100513811",null,"P31749, P31751, Q9Y243","P31750, Q60823, Q9WUA6","A0A8I5YBI2, A0A8I5Y943, A0A0G2JXD7","A0A8I3P9C5, A0A8I3MNQ3, A0A8I3MMB4","A0A287AQP0, A0A287AN96","A0A1D5RJS3, A0A1D5RH80, F6R8M1","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982; GO:0005938; GO:0005769; GO:0005768; GO:0043231; GO:0032587","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740; GO:0046872; GO:0140677","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929; GO:0090630; GO:0071486; GO:0045444; GO:0065002; GO:0030335; GO:2000147; GO:0032000; GO:0090314; GO:0031340; GO:0072659; GO:0036211; GO:0051726; GO:0097473; GO:0048854; GO:0048873; GO:0000002; GO:2000773; GO:0045766; GO:1905653; GO:0090050; GO:0045793; GO:0032008; GO:1905564","PTHR24356:SF171; PTHR24356:SF176; PTHR24356:SF190","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=392|UniProtKB=P31751; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=393|UniProtKB=Q9Y243","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006; P00047"]
["Akt1",null,"AKT1","60","ms",null,2,2,6,6,2,2,"# 1364",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle","Akt signaling / metabolism","AKT serine/threonine kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=207","207","11651",null,null,null,null,"P31749","P31750","A0A8I5YBI2","A0A8I3P9C5",null,"A0A1D5RJS3","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929","PTHR24356:SF171","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006"]
["Akt1",null,"AKT1","60","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2348",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle","Akt signaling / metabolism","AKT serine/threonine kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=207","207","11651",null,null,null,null,"P31749","P31750","A0A8I5YBI2","A0A8I3P9C5",null,"A0A1D5RJS3","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929","PTHR24356:SF171","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006"]
["Akt1 - phospho","Ser129","AKT1","60","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2349",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle",null,"AKT serine/threonine kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=207","207","11651",null,null,null,null,"P31749","P31750","A0A8I5YBI2","A0A8I3P9C5",null,"A0A1D5RJS3","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929","PTHR24356:SF171","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006"]
["Akt1 - phospho","Ser473","AKT1","60","rb",null,1,4.0999999999999996,8,8,1.1000000000000001,8,"# 2161",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; p53 pathway by glucose deprivation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE","activation-induced cell death of T cells; anoikis; apoptotic mitochondrial changes; apoptotic process; behavioral response to pain; carbohydrate metabolic process; carbohydrate transport; cell differentiation; cell migration involved in sprouting angiogenesis; cell population proliferation; cellular response to cadmium ion; cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to prostaglandin E stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; establishment of protein localization to mitochondrion; excitatory postsynaptic potential; execution phase of apoptosis; fibroblast migration; G protein-coupled receptor signaling pathway; gene expression; germ cell development; glucose homeostasis; glucose metabolic process; glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; glycogen metabolic process; I-kappaB kinase/NF-kappaB signaling; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; lipopolysaccharide-mediated signaling pathway; maintenance of protein location in mitochondrion; mammary gland epithelial cell differentiation; maternal placenta development; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of fatty acid beta-oxidation; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of leukocyte cell-cell adhesion; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of lymphocyte migration; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of Notch signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of release of cytochrome c from mitochondria; nervous system development; NIK/NF-kappaB signaling; nitric oxide biosynthetic process; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peripheral nervous system myelin maintenance; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of fibroblast migration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of I-kappaB phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to cell surface; positive regulation of protein localization to nucleus; positive regulation of protein localization to plasma membrane; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein catabolic process; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein ubiquitination; regulation of apoptotic process; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of mRNA stability; regulation of myelination; regulation of neuron projection development; regulation of postsynapse organization; regulation of protein localization; regulation of signal transduction by p53 class mediator; regulation of translation; regulation of type B pancreatic cell development; response to fluid shear stress; response to food; response to growth factor; response to growth hormone; response to heat; response to hormone; response to insulin-like growth factor stimulus; response to organic substance; response to oxidative stress; response to UV-A; signal transduction; sphingosine-1-phosphate receptor signaling pathway; striated muscle cell differentiation; T cell costimulation; TOR signaling","14-3-3 protein binding; ATP binding; calmodulin binding; enzyme binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; potassium channel activator activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; protein serine/threonine/tyrosine kinase activity; transferase activity","cell-cell junction; ciliary basal body; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; lamellipodium; membrane; microtubule cytoskeleton; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; protein-containing complex; spindle; vesicle","Akt signaling / metabolism","AKT serine/threonine kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=207","207","11651",null,null,null,null,"P31749","P31750","A0A8I5YBI2","A0A8I3P9C5",null,"A0A1D5RJS3","GO:0005911; GO:0036064; GO:0005737; GO:0005829; GO:0031234; GO:0098978; GO:0030027; GO:0016020; GO:0015630; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0032991; GO:0005819; GO:0031982","GO:0071889; GO:0005524; GO:0005516; GO:0019899; GO:0042802; GO:0016301; GO:0030235; GO:0000166; GO:0005547; GO:0043325; GO:0099104; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030291; GO:0004712; GO:0016740","GO:0006924; GO:0043276; GO:0008637; GO:0006915; GO:0048266; GO:0005975; GO:0008643; GO:0030154; GO:0002042; GO:0008283; GO:0071276; GO:0036294; GO:0071364; GO:0097011; GO:0071363; GO:0032869; GO:1990090; GO:0140052; GO:1901653; GO:0071380; GO:0034614; GO:0071356; GO:0035924; GO:0019221; GO:0007173; GO:0072655; GO:0060079; GO:0097194; GO:0010761; GO:0007186; GO:0010467; GO:0007281; GO:0042593; GO:0006006; GO:0005978; GO:0060709; GO:0005977; GO:0007249; GO:0006954; GO:0008286; GO:0048009; GO:0035655; GO:0035556; GO:0060716; GO:0031663; GO:0072656; GO:0060644; GO:0001893; GO:0043066; GO:0010507; GO:0043154; GO:0010951; GO:2001240; GO:0031999; GO:0010629; GO:2001243; GO:1903038; GO:0010748; GO:2000402; GO:0016242; GO:1901215; GO:0045746; GO:1902176; GO:0032091; GO:0006469; GO:0071901; GO:0031397; GO:0045861; GO:0090201; GO:0007399; GO:0038061; GO:0006809; GO:0001649; GO:0018105; GO:0018107; GO:0032287; GO:0014065; GO:0016310; GO:0043536; GO:0030307; GO:0008284; GO:0045737; GO:0051091; GO:0045893; GO:0032079; GO:0010595; GO:0001938; GO:0045600; GO:0010763; GO:1900087; GO:0010628; GO:0046326; GO:0010907; GO:0045725; GO:1903721; GO:0046889; GO:0010918; GO:0045429; GO:0051000; GO:0046622; GO:0033138; GO:0032436; GO:2000010; GO:1900182; GO:1903078; GO:0051247; GO:0001934; GO:0048661; GO:0010765; GO:0045944; GO:0043161; GO:0046777; GO:0030163; GO:0006606; GO:0043491; GO:0006468; GO:0016567; GO:0042981; GO:0030334; GO:0005979; GO:0043488; GO:0031641; GO:0010975; GO:0099175; GO:0032880; GO:1901796; GO:0006417; GO:2000074; GO:0034405; GO:0032094; GO:0070848; GO:0060416; GO:0009408; GO:0009725; GO:1990418; GO:0010033; GO:0006979; GO:0070141; GO:0007165; GO:0003376; GO:0051146; GO:0031295; GO:0031929","PTHR24356:SF171","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=391|UniProtKB=P31749","P06959; P00053; P00059; P04397; P00056; P00036; P00033; P06664; P00021; P04393; P00029; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006"]
["Akt2",null,"AKT2","60","rb",null,1.1000000000000001,1.1000000000000001,8,8,8.1,8,"# 2169",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .HUNT., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","T cell activation; p53 pathway; p53 pathway by glucose deprivation; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; FGF signaling pathway; Huntington disease; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","RAC-BETA SERINE/THREONINE-PROTEIN KINASE","activation of GTPase activity; apoptotic process; carbohydrate metabolic process; carbohydrate transport; cellular response to high light intensity; cellular response to insulin stimulus; fat cell differentiation; glucose metabolic process; glycogen biosynthetic process; glycogen metabolic process; insulin receptor signaling pathway; intracellular protein transmembrane transport; intracellular signal transduction; mammary gland epithelial cell differentiation; negative regulation of apoptotic process; negative regulation of long-chain fatty acid import across plasma membrane; peptidyl-serine phosphorylation; peripheral nervous system myelin maintenance; phosphorylation; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell population proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein modification process; protein phosphorylation; regulation of cell cycle; regulation of cell migration; regulation of translation; retinal rod cell apoptotic process; signal transduction","ATP binding; kinase activity; metal ion binding; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cell cortex; cytoplasm; cytosol; early endosome; endosome; intracellular membrane-bounded organelle; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ruffle membrane","Akt signaling / metabolism","AKT serine/threonine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=208","208","11652",null,null,null,null,"P31751","Q60823","A0A8I5Y943","A0A8I3MNQ3","A0A287AQP0","A0A1D5RH80","GO:0005938; GO:0005737; GO:0005829; GO:0005769; GO:0005768; GO:0043231; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0032587","GO:0005524; GO:0016301; GO:0046872; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0090630; GO:0006915; GO:0005975; GO:0008643; GO:0071486; GO:0032869; GO:0045444; GO:0006006; GO:0005978; GO:0005977; GO:0008286; GO:0065002; GO:0035556; GO:0060644; GO:0043066; GO:0010748; GO:0018105; GO:0032287; GO:0016310; GO:0030335; GO:2000147; GO:0008284; GO:0032000; GO:0046326; GO:0010907; GO:0045725; GO:0010918; GO:0001934; GO:0090314; GO:0031340; GO:0072659; GO:0036211; GO:0006468; GO:0051726; GO:0030334; GO:0006417; GO:0097473; GO:0007165","PTHR24356:SF176","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=392|UniProtKB=P31751","P00053; P00059; P04397; P00036; P00033; P00021; P00029; P00047; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006"]
["Akt2 - phospho","Ser474","AKT2","60","rb",null,2,1,8,8,1,1.1000000000000001,"# 2020",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .HUNT., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","T cell activation; p53 pathway; p53 pathway by glucose deprivation; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; FGF signaling pathway; Huntington disease; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","RAC-BETA SERINE/THREONINE-PROTEIN KINASE","activation of GTPase activity; apoptotic process; carbohydrate metabolic process; carbohydrate transport; cellular response to high light intensity; cellular response to insulin stimulus; fat cell differentiation; glucose metabolic process; glycogen biosynthetic process; glycogen metabolic process; insulin receptor signaling pathway; intracellular protein transmembrane transport; intracellular signal transduction; mammary gland epithelial cell differentiation; negative regulation of apoptotic process; negative regulation of long-chain fatty acid import across plasma membrane; peptidyl-serine phosphorylation; peripheral nervous system myelin maintenance; phosphorylation; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell population proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; protein modification process; protein phosphorylation; regulation of cell cycle; regulation of cell migration; regulation of translation; retinal rod cell apoptotic process; signal transduction","ATP binding; kinase activity; metal ion binding; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cell cortex; cytoplasm; cytosol; early endosome; endosome; intracellular membrane-bounded organelle; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ruffle membrane","Akt signaling / metabolism","AKT serine/threonine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=208","208","11652",null,null,null,null,"P31751","Q60823","A0A8I5Y943","A0A8I3MNQ3","A0A287AQP0","A0A1D5RH80","GO:0005938; GO:0005737; GO:0005829; GO:0005769; GO:0005768; GO:0043231; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0032587","GO:0005524; GO:0016301; GO:0046872; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0090630; GO:0006915; GO:0005975; GO:0008643; GO:0071486; GO:0032869; GO:0045444; GO:0006006; GO:0005978; GO:0005977; GO:0008286; GO:0065002; GO:0035556; GO:0060644; GO:0043066; GO:0010748; GO:0018105; GO:0032287; GO:0016310; GO:0030335; GO:2000147; GO:0008284; GO:0032000; GO:0046326; GO:0010907; GO:0045725; GO:0010918; GO:0001934; GO:0090314; GO:0031340; GO:0072659; GO:0036211; GO:0006468; GO:0051726; GO:0030334; GO:0006417; GO:0097473; GO:0007165","PTHR24356:SF176","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=392|UniProtKB=P31751","P00053; P00059; P04397; P00036; P00033; P00021; P00029; P00047; P00005; P00018; P00030; P00020; P00031; P00019; P00048; P04398; P00006"]
["Akt3",null,"AKT3","60","rb",null,1.1000000000000001,4,4,4,4,4,"# 1365",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .HUNT., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .VEGFS.","T cell activation; p53 pathway; p53 pathway by glucose deprivation; Interleukin signaling pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE","brain morphogenesis; homeostasis of number of cells within a tissue; intracellular signal transduction; mitochondrial genome maintenance; negative regulation of cellular senescence; peptidyl-serine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of artery morphogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell size; positive regulation of endothelial cell proliferation; positive regulation of TOR signaling; positive regulation of vascular endothelial cell proliferation; protein phosphorylation; signal transduction","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; membrane; nucleus","Akt signaling / metabolism","AKT serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=10000","10000","23797",null,null,"100513811",null,"Q9Y243","Q9WUA6","A0A0G2JXD7","A0A8I3MMB4","A0A287AN96","F6R8M1","GO:0005737; GO:0016020; GO:0005634","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0048854; GO:0048873; GO:0035556; GO:0000002; GO:2000773; GO:0018105; GO:0016310; GO:0045766; GO:1905653; GO:0043536; GO:0090050; GO:0045793; GO:0001938; GO:0032008; GO:1905564; GO:0006468; GO:0007165","PTHR24356:SF190","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=393|UniProtKB=Q9Y243","P00053; P00059; P04397; P00036; P00021; P04393; P00029; P00005; P00018; P00030; P00031; P00019; P00048; P04398; P00006"]
["Aldh1A1 (alcohol dehydrogenase beta subunit)",null,"ALDH1A1","55","rb",null,1,1,1,1,1,1,"# 0451",null,"5-Hydroxytryptamine degredation","RETINAL DEHYDROGENASE 1","cellular aldehyde metabolic process; cellular detoxification of aldehyde; fructosamine catabolic process; gamma-aminobutyric acid biosynthetic process; lipid metabolic process; maintenance of lens transparency; negative regulation of cold-induced thermogenesis; retinoid metabolic process; retinol metabolic process","3-deoxyglucosone dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; aminobutyraldehyde dehydrogenase activity; androgen binding; benzaldehyde dehydrogenase (NAD+) activity; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; GTPase activator activity; NAD binding; nucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; protein binding; retinal dehydrogenase activity","axon; cell projection; cytoplasm; cytosol; extracellular exosome; synapse","Metabolism","aldehyde dehydrogenase 1 family member A1","http://www.ncbi.nlm.nih.gov/gene/?term=216","216","11668",null,"476323",null,null,"P00352","P24549","A0A8I6ALC9","A0A8I3M9Q4","A0A287BRG6","A0A1D5QAD4","GO:0030424; GO:0042995; GO:0005737; GO:0005829; GO:0070062; GO:0045202","GO:0106373; GO:0004029; GO:0019145; GO:0005497; GO:0018479; GO:0043878; GO:0005096; GO:0051287; GO:0000166; GO:0016491; GO:0016620; GO:0005515; GO:0001758","GO:0006081; GO:0110095; GO:0030392; GO:0009449; GO:0006629; GO:0036438; GO:0120163; GO:0001523; GO:0042572","PTHR11699:SF140","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=402|UniProtKB=P00352","P04372"]
["alpha-Catenin",null,"CTNNA1","102","ms",null,2,1,1,1,2,1,"# 1678",".ALZ., .APO., .CADH., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .DI., .EMC., .HHSP., .HIPPO., .INT., .MIG., .OP., .OPA., .OT., .WNT.","Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Wnt signaling pathway","CATENIN ALPHA-1","aging; apical junction assembly; apoptotic process; axon regeneration; cell adhesion; cell migration; cell motility; cell-cell adhesion; cellular response to indole-3-methanol; epithelial cell-cell adhesion; establishment or maintenance of cell polarity; extrinsic apoptotic signaling pathway in absence of ligand; gap junction assembly; integrin-mediated signaling pathway; male gonad development; negative regulation of apoptotic process; negative regulation of cell motility; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of integrin-mediated signaling pathway; negative regulation of neuroblast proliferation; negative regulation of protein localization to nucleus; neuroblast proliferation; odontogenesis of dentin-containing tooth; ovarian follicle development; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of smoothened signaling pathway; protein localization; regulation of cell population proliferation; response to estrogen; response to organic cyclic compound; smoothened signaling pathway","actin filament binding; beta-catenin binding; cadherin binding; gamma-catenin binding; identical protein binding; protein binding; protein-containing complex binding; RNA binding; structural molecule activity; vinculin binding","acrosomal vesicle; actin cytoskeleton; adherens junction; anchoring junction; catenin complex; cell junction; cell-cell junction; cellular anatomical entity; cytoplasm; cytoskeleton; cytosol; flotillin complex; focal adhesion; intercalated disc; intracellular membrane-bounded organelle; lamellipodium; membrane; plasma membrane; zonula adherens","Wnt signaling","catenin alpha 1","http://www.ncbi.nlm.nih.gov/gene/?term=1495","1495","12385","307505",null,null,null,"P35221","P26231","Q5U302","A0A8I3PEF2","A0A287AJ96","F7DN31","GO:0001669; GO:0015629; GO:0005912; GO:0070161; GO:0016342; GO:0030054; GO:0005911; GO:0110165; GO:0005737; GO:0005856; GO:0005829; GO:0016600; GO:0005925; GO:0014704; GO:0043231; GO:0030027; GO:0016020; GO:0005886; GO:0005915","GO:0051015; GO:0008013; GO:0045296; GO:0045295; GO:0042802; GO:0005515; GO:0044877; GO:0003723; GO:0005198; GO:0017166","GO:0007568; GO:0043297; GO:0006915; GO:0031103; GO:0007155; GO:0016477; GO:0048870; GO:0098609; GO:0071681; GO:0090136; GO:0007163; GO:0097192; GO:0016264; GO:0007229; GO:0008584; GO:0043066; GO:2000146; GO:2001240; GO:2001045; GO:0007406; GO:1900181; GO:0007405; GO:0042475; GO:0001541; GO:2001241; GO:0045880; GO:0008104; GO:0042127; GO:0043627; GO:0014070; GO:0007224","PTHR18914:SF24","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2509|UniProtKB=P35221","P00004; P00012; P00057"]
["alpha-Smooth Muscle Actin",null,"ACTA2","42","rb",null,1,2,"n/a","n/a","n/a","n/a","# 2107",".ALZ., .CADH., .CSP., .DEV., .DI., .HUNT., .IMUF., .IMUR., .INFM., .INT., .MAPK., .OP., .OPA., .OT., .RTK., .TRASR., .VIR., .WNT.","Huntington disease; Nicotinic acetylcholine receptor signaling pathway; Alzheimer disease-presenilin pathway; Cytoskeletal regulation by Rho GTPase; Cadherin signaling pathway; Integrin signalling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","ACTIN, AORTIC SMOOTH MUSCLE","cellular response to transforming growth factor beta stimulus; glomerular mesangial cell development; mesenchyme migration; muscle contraction; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of hepatic stellate cell activation; positive regulation of hepatic stellate cell contraction; positive regulation of hepatic stellate cell migration; regulation of blood pressure; regulation of wound healing; response to virus; vascular associated smooth muscle contraction","ATP binding; hydrolase activity; nucleotide binding; protein kinase binding","actin cytoskeleton; basement membrane; cell body; cytoplasm; cytoskeleton; cytosol; dynactin complex; extracellular exosome; extracellular space; filopodium; lamellipodium; motile cilium; protein-containing complex; smooth muscle contractile fiber; stress fiber",null,"actin alpha 2, smooth muscle","http://www.ncbi.nlm.nih.gov/gene/?term=59","59","11475","81633","477587",null,null,"P62736","P62737","P62738","A0A8I3Q4M4","A0A287ANW0","F6UA54","GO:0015629; GO:0005604; GO:0044297; GO:0005737; GO:0005856; GO:0005829; GO:0005869; GO:0070062; GO:0005615; GO:0030175; GO:0030027; GO:0031514; GO:0032991; GO:0030485; GO:0001725","GO:0005524; GO:0016787; GO:0000166; GO:0019901","GO:0071560; GO:0072144; GO:0090131; GO:0006936; GO:0070374; GO:0010628; GO:2000491; GO:0061874; GO:0061870; GO:0008217; GO:0061041; GO:0009615; GO:0014829","PTHR11937:SF445","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=130|UniProtKB=P62736","P00029; P00044; P00004; P00016; P00012; P00034; P00031; P00057"]
["alpha-Tubulin",null,"TUBA4A","50","ms",null,2,1,2,2,1,2,"# 2141",".ALZ., .APO., .CCP., .CCY., .CD., .CSP., .DI., .HUNT., .OP.",null,"TUBULIN ALPHA-4A CHAIN","microtubule cytoskeleton organization; microtubule-based process; mitotic cell cycle","GTP binding; hydrolase activity; metal ion binding; nucleotide binding; protein binding; protein kinase binding; structural constituent of cytoskeleton","cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular region; microtubule; microtubule cytoskeleton","Cytoskeletal signaling","tubulin alpha 4a","http://www.ncbi.nlm.nih.gov/gene/?term=7277","7277","22145","316531","478918",null,"702583","P68366","P68368","Q5XIF6","A0A8I3Q1H9","A0A5G2QX54","F6QRE8","GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005576; GO:0005874; GO:0015630","GO:0005525; GO:0016787; GO:0046872; GO:0000166; GO:0005515; GO:0019901; GO:0005200","GO:0000226; GO:0007017; GO:0000278","PTHR11588:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12407|UniProtKB=P68366"]
["alpha-Tubulin acetylated",null,"TUBA4A","50","ms",null,1,1,1,2,1,8,"# 0912",".ALZ., .APO., .CCP., .CCY., .CD., .CSP., .DI., .HUNT., .OP.",null,"TUBULIN ALPHA-4A CHAIN","microtubule cytoskeleton organization; microtubule-based process; mitotic cell cycle","GTP binding; hydrolase activity; metal ion binding; nucleotide binding; protein binding; protein kinase binding; structural constituent of cytoskeleton","cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular region; microtubule; microtubule cytoskeleton","Cytoskeletal regulation / Adhesion","tubulin alpha 4a","http://www.ncbi.nlm.nih.gov/gene/?term=7277","7277","22145","316531","478918",null,"702583","P68366","P68368","Q5XIF6","A0A8I3Q1H9","A0A5G2QX54","F6QRE8","GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005576; GO:0005874; GO:0015630","GO:0005525; GO:0016787; GO:0046872; GO:0000166; GO:0005515; GO:0019901; GO:0005200","GO:0000226; GO:0007017; GO:0000278","PTHR11588:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12407|UniProtKB=P68366"]
["AML1",null,"RUNX1","55","rb",null,1,2,8,6,1,8,"# 1540",".AML., .ANG., .CANCER., .CANPTHW., .CCP., .CML., .CP., .OP., .OT., .TCD., .TMAT., .TRASR.",null,"RUNT-RELATED TRANSCRIPTION FACTOR 1","cardiac muscle tissue regeneration; chondrocyte differentiation; hematopoietic stem cell proliferation; hemopoiesis; myeloid leukocyte differentiation; negative regulation of CD4-positive, alpha-beta T cell differentiation; negative regulation of transcription by RNA polymerase II; neuron differentiation; ossification; peripheral nervous system neuron development; positive regulation of angiogenesis; positive regulation of CD8-positive, alpha-beta T cell differentiation; positive regulation of collagen biosynthetic process; positive regulation of developmental process; positive regulation of DNA-templated transcription; positive regulation of extracellular matrix organization; positive regulation of granulocyte differentiation; positive regulation of interleukin-2 production; positive regulation of transcription by RNA polymerase II; regulation of cardiac muscle cell proliferation; regulation of cell differentiation; regulation of connective tissue replacement; regulation of DNA-templated transcription; regulation of plasminogen activation; regulation of transcription by RNA polymerase II","ATP binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; core-binding factor complex; intracellular membrane-bounded organelle; nucleoplasm; nucleus","Lymphocyte signaling","RUNX family transcription factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=861","861",null,"50662",null,null,"696749","Q01196","A0A087WPL0","Q63046","A0A8I3PSG0",null,"F6PP34","GO:0000785; GO:0016513; GO:0043231; GO:0005654; GO:0005634","GO:0005524; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0000978; GO:0000977; GO:1990837; GO:0000976","GO:0061026; GO:0002062; GO:0071425; GO:0030097; GO:0002573; GO:0043371; GO:0000122; GO:0030182; GO:0001503; GO:0048935; GO:0045766; GO:0043378; GO:0032967; GO:0051094; GO:0045893; GO:1903055; GO:0030854; GO:0032743; GO:0045944; GO:0060043; GO:0045595; GO:1905203; GO:0006355; GO:0010755; GO:0006357","PTHR11950:SF40","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10471|UniProtKB=Q01196"]
["AML1 - phospho","Ser249","RUNX1","55","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1516",".AML., .ANG., .CANCER., .CANPTHW., .CCP., .CML., .CP., .OP., .OT., .TCD., .TMAT., .TRASR.",null,"RUNT-RELATED TRANSCRIPTION FACTOR 1","cardiac muscle tissue regeneration; chondrocyte differentiation; hematopoietic stem cell proliferation; hemopoiesis; myeloid leukocyte differentiation; negative regulation of CD4-positive, alpha-beta T cell differentiation; negative regulation of transcription by RNA polymerase II; neuron differentiation; ossification; peripheral nervous system neuron development; positive regulation of angiogenesis; positive regulation of CD8-positive, alpha-beta T cell differentiation; positive regulation of collagen biosynthetic process; positive regulation of developmental process; positive regulation of DNA-templated transcription; positive regulation of extracellular matrix organization; positive regulation of granulocyte differentiation; positive regulation of interleukin-2 production; positive regulation of transcription by RNA polymerase II; regulation of cardiac muscle cell proliferation; regulation of cell differentiation; regulation of connective tissue replacement; regulation of DNA-templated transcription; regulation of plasminogen activation; regulation of transcription by RNA polymerase II","ATP binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; core-binding factor complex; intracellular membrane-bounded organelle; nucleoplasm; nucleus","Lymphocyte signaling","RUNX family transcription factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=861","861",null,"50662",null,null,"696749","Q01196","A0A087WPL0","Q63046","A0A8I3PSG0",null,"F6PP34","GO:0000785; GO:0016513; GO:0043231; GO:0005654; GO:0005634","GO:0005524; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0000978; GO:0000977; GO:1990837; GO:0000976","GO:0061026; GO:0002062; GO:0071425; GO:0030097; GO:0002573; GO:0043371; GO:0000122; GO:0030182; GO:0001503; GO:0048935; GO:0045766; GO:0043378; GO:0032967; GO:0051094; GO:0045893; GO:1903055; GO:0030854; GO:0032743; GO:0045944; GO:0060043; GO:0045595; GO:1905203; GO:0006355; GO:0010755; GO:0006357","PTHR11950:SF40","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10471|UniProtKB=Q01196"]
["AMPA receptor (GluR2)",null,"GRIA2","100","rb",null,4,7,"n/a","n/a","n/a","n/a","# 1528",".cAMP., .CSP., .DI., .GPCR., .HUNT., .OP., .OPA., .ST.","Ionotropic glutamate receptor pathway; Metabotropic glutamate receptor group III pathway","GLUTAMATE RECEPTOR 2","chemical synaptic transmission; glutamate receptor signaling pathway; ion transmembrane transport; ion transport; ionotropic glutamate receptor signaling pathway; signal transduction; synaptic transmission, glutamatergic","AMPA glutamate receptor activity; amyloid-beta binding; ion channel activity; ionotropic glutamate receptor activity; ligand-gated ion channel activity; protein binding; signaling receptor activity","AMPA glutamate receptor complex; asymmetric synapse; dendrite; dendritic spine; endocytic vesicle membrane; endoplasmic reticulum; endoplasmic reticulum membrane; excitatory synapse; external side of plasma membrane; membrane; neuronal cell body; plasma membrane; postsynapse; postsynaptic density; postsynaptic density membrane; postsynaptic endocytic zone; postsynaptic membrane; synapse","Neuroscience","glutamate ionotropic receptor AMPA type subunit 2","http://www.ncbi.nlm.nih.gov/gene/?term=2891","2891",null,null,null,null,null,"P42262","A0A0A6YW90","A0A8I6AC88","A0A8I3N7V7","A0A287AEG6","A0A1D5QCP7","GO:0032281; GO:0032279; GO:0030425; GO:0043197; GO:0030666; GO:0005783; GO:0005789; GO:0060076; GO:0009897; GO:0016020; GO:0043025; GO:0005886; GO:0098794; GO:0014069; GO:0098839; GO:0098843; GO:0045211; GO:0045202","GO:0004971; GO:0001540; GO:0005216; GO:0004970; GO:0015276; GO:0005515; GO:0038023","GO:0007268; GO:0007215; GO:0034220; GO:0006811; GO:0035235; GO:0007165; GO:0035249","PTHR18966:SF99","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4572|UniProtKB=P42262","P00037; P00039"]
["AMPK alpha",null,"PRKAA1","62","rb",null,2,2,2,2,2,1,"TK # 028",".AMPK., .APH., .APO., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DMTOR., .DRAS., .DRR., .FOXO., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .RTK., .SREME., .ST., .TRASR., .WNT.","p53 pathway by glucose deprivation; Gonadotropin releasing hormone receptor pathway","5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1","autophagy; bile acid and bile salt transport; bile acid signaling pathway; CAMKK-AMPK signaling cascade; cellular response to calcium ion; cellular response to ethanol; cellular response to glucose starvation; cellular response to glucose stimulus; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to nutrient levels; cellular response to organonitrogen compound; cellular response to oxidative stress; cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; cholesterol biosynthetic process; cholesterol metabolic process; chromatin organization; cold acclimation; energy homeostasis; fatty acid biosynthetic process; fatty acid homeostasis; fatty acid metabolic process; fatty acid oxidation; glucose homeostasis; glucose metabolic process; histone modification; intracellular signal transduction; lipid biosynthetic process; lipid droplet disassembly; lipid metabolic process; motor behavior; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of glucosylceramide biosynthetic process; negative regulation of hepatocyte apoptotic process; negative regulation of insulin receptor signaling pathway; negative regulation of lipid catabolic process; negative regulation of TOR signaling; negative regulation of tubulin deacetylation; neuron cellular homeostasis; phosphorylation; positive regulation of autophagy; positive regulation of cell population proliferation; positive regulation of cellular catabolic process; positive regulation of cholesterol biosynthetic process; positive regulation of gene expression; positive regulation of glycolytic process; positive regulation of mitochondrial transcription; positive regulation of peptidyl-lysine acetylation; positive regulation of protein localization; positive regulation of protein targeting to mitochondrion; positive regulation of skeletal muscle tissue development; protein localization to lipid droplet; protein phosphorylation; regulation of bile acid secretion; regulation of circadian rhythm; regulation of gene expression; regulation of microtubule cytoskeleton organization; regulation of peptidyl-serine phosphorylation; regulation of stress granule assembly; regulation of vesicle-mediated transport; response to 17alpha-ethynylestradiol; response to activity; response to caffeine; response to camptothecin; response to gamma radiation; response to hydrogen peroxide; response to hypoxia; response to UV; response to xenobiotic stimulus; rhythmic process; signal transduction; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process; Wnt signaling pathway","[acetyl-CoA carboxylase] kinase activity; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity; AMP-activated protein kinase activity; ATP binding; cAMP-dependent protein kinase activity; chromatin binding; histone serine kinase activity; kinase activity; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; tau protein binding; tau-protein kinase activity; transferase activity","apical plasma membrane; axon; cytoplasm; cytosol; dendrite; neuronal cell body; nuclear speck; nucleoplasm; nucleotide-activated protein kinase complex; nucleus; protein-containing complex","Metabolism","protein kinase AMP-activated catalytic subunit alpha 1","http://www.ncbi.nlm.nih.gov/gene/?term=5562","5562","105787","65248",null,null,null,"Q13131","Q5EG47","P54645","A0A8I3MG89","A0A5G2QTG6","F7HR67","GO:0016324; GO:0030424; GO:0005737; GO:0005829; GO:0030425; GO:0043025; GO:0016607; GO:0005654; GO:0031588; GO:0005634; GO:0032991","GO:0050405; GO:0047322; GO:0004679; GO:0005524; GO:0004691; GO:0003682; GO:0035174; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0008022; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0048156; GO:0050321; GO:0016740","GO:0006914; GO:0015721; GO:0038183; GO:0061762; GO:0071277; GO:0071361; GO:0042149; GO:0071333; GO:0070301; GO:0071456; GO:0031669; GO:0071417; GO:0034599; GO:0071380; GO:0071466; GO:0006695; GO:0008203; GO:0006325; GO:0009631; GO:0097009; GO:0006633; GO:0055089; GO:0006631; GO:0019395; GO:0042593; GO:0006006; GO:0016570; GO:0035556; GO:0008610; GO:1905691; GO:0006629; GO:0061744; GO:0043066; GO:0010629; GO:0046318; GO:1903944; GO:0046627; GO:0050995; GO:0032007; GO:1904428; GO:0070050; GO:0016310; GO:0010508; GO:0008284; GO:0031331; GO:0045542; GO:0010628; GO:0045821; GO:1903109; GO:2000758; GO:1903829; GO:1903955; GO:0048643; GO:1990044; GO:0006468; GO:0120188; GO:0042752; GO:0010468; GO:0070507; GO:0033135; GO:0062028; GO:0060627; GO:1904486; GO:0014823; GO:0031000; GO:1901563; GO:0010332; GO:0042542; GO:0001666; GO:0009411; GO:0009410; GO:0048511; GO:0007165; GO:0006694; GO:0008202; GO:0016126; GO:0016055","PTHR24343:SF306","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9376|UniProtKB=Q13131","P04397; P06664"]
["AMPK alpha - phospho","Thr172","PRKAA1","62","rb",null,1,1,1,1.1000000000000001,1,1.1000000000000001,"# 0437",".AMPK., .APH., .APO., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DMTOR., .DRAS., .DRR., .FOXO., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .RTK., .SREME., .ST., .TRASR., .WNT.","p53 pathway by glucose deprivation; Gonadotropin releasing hormone receptor pathway","5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1","autophagy; bile acid and bile salt transport; bile acid signaling pathway; CAMKK-AMPK signaling cascade; cellular response to calcium ion; cellular response to ethanol; cellular response to glucose starvation; cellular response to glucose stimulus; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to nutrient levels; cellular response to organonitrogen compound; cellular response to oxidative stress; cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; cholesterol biosynthetic process; cholesterol metabolic process; chromatin organization; cold acclimation; energy homeostasis; fatty acid biosynthetic process; fatty acid homeostasis; fatty acid metabolic process; fatty acid oxidation; glucose homeostasis; glucose metabolic process; histone modification; intracellular signal transduction; lipid biosynthetic process; lipid droplet disassembly; lipid metabolic process; motor behavior; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of glucosylceramide biosynthetic process; negative regulation of hepatocyte apoptotic process; negative regulation of insulin receptor signaling pathway; negative regulation of lipid catabolic process; negative regulation of TOR signaling; negative regulation of tubulin deacetylation; neuron cellular homeostasis; phosphorylation; positive regulation of autophagy; positive regulation of cell population proliferation; positive regulation of cellular catabolic process; positive regulation of cholesterol biosynthetic process; positive regulation of gene expression; positive regulation of glycolytic process; positive regulation of mitochondrial transcription; positive regulation of peptidyl-lysine acetylation; positive regulation of protein localization; positive regulation of protein targeting to mitochondrion; positive regulation of skeletal muscle tissue development; protein localization to lipid droplet; protein phosphorylation; regulation of bile acid secretion; regulation of circadian rhythm; regulation of gene expression; regulation of microtubule cytoskeleton organization; regulation of peptidyl-serine phosphorylation; regulation of stress granule assembly; regulation of vesicle-mediated transport; response to 17alpha-ethynylestradiol; response to activity; response to caffeine; response to camptothecin; response to gamma radiation; response to hydrogen peroxide; response to hypoxia; response to UV; response to xenobiotic stimulus; rhythmic process; signal transduction; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process; Wnt signaling pathway","[acetyl-CoA carboxylase] kinase activity; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity; AMP-activated protein kinase activity; ATP binding; cAMP-dependent protein kinase activity; chromatin binding; histone serine kinase activity; kinase activity; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; tau protein binding; tau-protein kinase activity; transferase activity","apical plasma membrane; axon; cytoplasm; cytosol; dendrite; neuronal cell body; nuclear speck; nucleoplasm; nucleotide-activated protein kinase complex; nucleus; protein-containing complex","Metabolism","protein kinase AMP-activated catalytic subunit alpha 1","http://www.ncbi.nlm.nih.gov/gene/?term=5562","5562","105787","65248",null,null,null,"Q13131","Q5EG47","P54645","A0A8I3MG89","A0A5G2QTG6","F7HR67","GO:0016324; GO:0030424; GO:0005737; GO:0005829; GO:0030425; GO:0043025; GO:0016607; GO:0005654; GO:0031588; GO:0005634; GO:0032991","GO:0050405; GO:0047322; GO:0004679; GO:0005524; GO:0004691; GO:0003682; GO:0035174; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0008022; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0048156; GO:0050321; GO:0016740","GO:0006914; GO:0015721; GO:0038183; GO:0061762; GO:0071277; GO:0071361; GO:0042149; GO:0071333; GO:0070301; GO:0071456; GO:0031669; GO:0071417; GO:0034599; GO:0071380; GO:0071466; GO:0006695; GO:0008203; GO:0006325; GO:0009631; GO:0097009; GO:0006633; GO:0055089; GO:0006631; GO:0019395; GO:0042593; GO:0006006; GO:0016570; GO:0035556; GO:0008610; GO:1905691; GO:0006629; GO:0061744; GO:0043066; GO:0010629; GO:0046318; GO:1903944; GO:0046627; GO:0050995; GO:0032007; GO:1904428; GO:0070050; GO:0016310; GO:0010508; GO:0008284; GO:0031331; GO:0045542; GO:0010628; GO:0045821; GO:1903109; GO:2000758; GO:1903829; GO:1903955; GO:0048643; GO:1990044; GO:0006468; GO:0120188; GO:0042752; GO:0010468; GO:0070507; GO:0033135; GO:0062028; GO:0060627; GO:1904486; GO:0014823; GO:0031000; GO:1901563; GO:0010332; GO:0042542; GO:0001666; GO:0009411; GO:0009410; GO:0048511; GO:0007165; GO:0006694; GO:0008202; GO:0016126; GO:0016055","PTHR24343:SF306","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9376|UniProtKB=Q13131","P04397; P06664"]
["Androgen receptor",null,"AR","99","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1238",".APO., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .IMUF., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .PRC., .RTK., .SREME., .ST., .TRASR.","Gonadotropin releasing hormone receptor pathway","ANDROGEN RECEPTOR","activation of prostate induction by androgen receptor signaling pathway; androgen receptor signaling pathway; animal organ formation; cell-cell signaling; cellular response to estrogen stimulus; cellular response to steroid hormone stimulus; cellular response to testosterone stimulus; epithelial cell differentiation involved in prostate gland development; epithelial cell morphogenesis; epithelial cell proliferation; fertilization; in utero embryonic development; insulin-like growth factor receptor signaling pathway; intracellular estrogen receptor signaling pathway; intracellular receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; lateral sprouting involved in mammary gland duct morphogenesis; Leydig cell differentiation; male genitalia morphogenesis; male gonad development; male somatic sex determination; mammary gland alveolus development; MAPK cascade; morphogenesis of an epithelial fold; multicellular organism growth; negative regulation of cell population proliferation; negative regulation of epithelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of integrin biosynthetic process; negative regulation of transcription by RNA polymerase II; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of gene expression; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of integrin biosynthetic process; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of miRNA transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase III; prostate gland epithelium morphogenesis; prostate gland growth; regulation of developmental growth; regulation of DNA-templated transcription; regulation of gene expression; regulation of prostatic bud formation; regulation of protein localization to plasma membrane; regulation of systemic arterial blood pressure; regulation of transcription by RNA polymerase II; reproductive structure development; reproductive system development; seminiferous tubule development; signal transduction; single fertilization; spermatogenesis; tertiary branching involved in mammary gland duct morphogenesis; transcription by RNA polymerase II","androgen binding; ATPase binding; beta-catenin binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; lipid binding; metal ion binding; molecular adaptor activity; nuclear receptor activity; POU domain binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II general transcription initiation factor binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling receptor binding; steroid binding; transcription cis-regulatory region binding; transcription coactivator binding; zinc ion binding","chromatin; cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus; plasma membrane; protein-containing complex","Nuclear receptor","androgen receptor","http://www.ncbi.nlm.nih.gov/gene/?term=367","367","11835",null,null,null,null,"P10275","P19091","A0A0G2JSI8","A0A8I3PZ26","A0A287AHV0","F7B9Z6","GO:0000785; GO:0005737; GO:0005829; GO:0016607; GO:0005654; GO:0005634; GO:0005886; GO:0032991","GO:0005497; GO:0051117; GO:0008013; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0008289; GO:0046872; GO:0060090; GO:0004879; GO:0070974; GO:0005515; GO:0000978; GO:0001091; GO:0061629; GO:0043565; GO:0005102; GO:0005496; GO:0000976; GO:0001223; GO:0008270","GO:0060520; GO:0030521; GO:0048645; GO:0007267; GO:0071391; GO:0071383; GO:0071394; GO:0060742; GO:0003382; GO:0050673; GO:0009566; GO:0001701; GO:0048009; GO:0030520; GO:0030522; GO:0030518; GO:0060599; GO:0033327; GO:0048808; GO:0008584; GO:0019102; GO:0060749; GO:0000165; GO:0060571; GO:0035264; GO:0008285; GO:0050680; GO:2001237; GO:0045720; GO:0000122; GO:0045597; GO:0008284; GO:0045893; GO:0060769; GO:0010628; GO:0043568; GO:0045726; GO:0033148; GO:0043410; GO:1902895; GO:0051092; GO:0042327; GO:0045944; GO:0045945; GO:0060740; GO:0060736; GO:0048638; GO:0006355; GO:0010468; GO:0060685; GO:1903076; GO:0003073; GO:0006357; GO:0048608; GO:0061458; GO:0072520; GO:0007165; GO:0007338; GO:0007283; GO:0060748; GO:0006366","PTHR48092:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=644|UniProtKB=P10275","P06664"]
["Androgen Receptor",null,"AR","110","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2231",".APO., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .IMUF., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .PRC., .RTK., .SREME., .ST., .TRASR.","Gonadotropin releasing hormone receptor pathway","ANDROGEN RECEPTOR","activation of prostate induction by androgen receptor signaling pathway; androgen receptor signaling pathway; animal organ formation; cell-cell signaling; cellular response to estrogen stimulus; cellular response to steroid hormone stimulus; cellular response to testosterone stimulus; epithelial cell differentiation involved in prostate gland development; epithelial cell morphogenesis; epithelial cell proliferation; fertilization; in utero embryonic development; insulin-like growth factor receptor signaling pathway; intracellular estrogen receptor signaling pathway; intracellular receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; lateral sprouting involved in mammary gland duct morphogenesis; Leydig cell differentiation; male genitalia morphogenesis; male gonad development; male somatic sex determination; mammary gland alveolus development; MAPK cascade; morphogenesis of an epithelial fold; multicellular organism growth; negative regulation of cell population proliferation; negative regulation of epithelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of integrin biosynthetic process; negative regulation of transcription by RNA polymerase II; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of gene expression; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of integrin biosynthetic process; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of miRNA transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase III; prostate gland epithelium morphogenesis; prostate gland growth; regulation of developmental growth; regulation of DNA-templated transcription; regulation of gene expression; regulation of prostatic bud formation; regulation of protein localization to plasma membrane; regulation of systemic arterial blood pressure; regulation of transcription by RNA polymerase II; reproductive structure development; reproductive system development; seminiferous tubule development; signal transduction; single fertilization; spermatogenesis; tertiary branching involved in mammary gland duct morphogenesis; transcription by RNA polymerase II","androgen binding; ATPase binding; beta-catenin binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; lipid binding; metal ion binding; molecular adaptor activity; nuclear receptor activity; POU domain binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II general transcription initiation factor binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling receptor binding; steroid binding; transcription cis-regulatory region binding; transcription coactivator binding; zinc ion binding","chromatin; cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus; plasma membrane; protein-containing complex","Nuclear receptor","androgen receptor","http://www.ncbi.nlm.nih.gov/gene/?term=367","367","11835",null,null,null,null,"P10275","P19091","A0A0G2JSI8","A0A8I3PZ26","A0A287AHV0","F7B9Z6","GO:0000785; GO:0005737; GO:0005829; GO:0016607; GO:0005654; GO:0005634; GO:0005886; GO:0032991","GO:0005497; GO:0051117; GO:0008013; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0008289; GO:0046872; GO:0060090; GO:0004879; GO:0070974; GO:0005515; GO:0000978; GO:0001091; GO:0061629; GO:0043565; GO:0005102; GO:0005496; GO:0000976; GO:0001223; GO:0008270","GO:0060520; GO:0030521; GO:0048645; GO:0007267; GO:0071391; GO:0071383; GO:0071394; GO:0060742; GO:0003382; GO:0050673; GO:0009566; GO:0001701; GO:0048009; GO:0030520; GO:0030522; GO:0030518; GO:0060599; GO:0033327; GO:0048808; GO:0008584; GO:0019102; GO:0060749; GO:0000165; GO:0060571; GO:0035264; GO:0008285; GO:0050680; GO:2001237; GO:0045720; GO:0000122; GO:0045597; GO:0008284; GO:0045893; GO:0060769; GO:0010628; GO:0043568; GO:0045726; GO:0033148; GO:0043410; GO:1902895; GO:0051092; GO:0042327; GO:0045944; GO:0045945; GO:0060740; GO:0060736; GO:0048638; GO:0006355; GO:0010468; GO:0060685; GO:1903076; GO:0003073; GO:0006357; GO:0048608; GO:0061458; GO:0072520; GO:0007165; GO:0007338; GO:0007283; GO:0060748; GO:0006366","PTHR48092:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=644|UniProtKB=P10275","P06664"]
["Annexin II",null,"ANXA2","36","ms",null,1,1,1,1,1,1,"# 0504",".ANG., .CANCER., .OP., .OT., .PLAT., .TRASR.",null,"ANNEXIN A2-RELATED","angiogenesis; calcium ion transmembrane transport; cell-cell adhesion; collagen fibril organization; fibrinolysis; membrane raft assembly; mRNA transcription by RNA polymerase II; negative regulation of low-density lipoprotein particle receptor catabolic process; negative regulation of receptor internalization; osteoclast development; positive regulation of binding; positive regulation of exocytosis; positive regulation of low-density lipoprotein particle clearance; positive regulation of low-density lipoprotein particle receptor binding; positive regulation of low-density lipoprotein receptor activity; positive regulation of plasma membrane repair; positive regulation of plasminogen activation; positive regulation of receptor recycling; positive regulation of receptor-mediated endocytosis involved in cholesterol transport; positive regulation of transcription by RNA polymerase II; positive regulation of vacuole organization; positive regulation of vesicle fusion; regulation of neurogenesis; vesicle budding from membrane","cadherin binding involved in cell-cell adhesion; calcium channel activity; calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; cytoskeletal protein binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; phospholipase A2 inhibitor activity; phospholipase inhibitor activity; protease binding; protein binding; RNA binding; S100 protein binding; serine-type endopeptidase inhibitor activity; virion binding","adherens junction; AnxA2-p11 complex; azurophil granule lumen; basement membrane; basolateral plasma membrane; cell surface; collagen-containing extracellular matrix; cornified envelope; cytoplasm; cytosol; early endosome; endosome; extracellular exosome; extracellular region; extracellular space; late endosome membrane; lipid droplet; lysosomal membrane; melanosome; membrane; membrane raft; midbody; myelin sheath adaxonal region; nuclear matrix; nucleus; PCSK9-AnxA2 complex; plasma membrane; plasma membrane protein complex; RNA polymerase II transcription regulator complex; sarcolemma; Schmidt-Lanterman incisure; vesicle","Cytoskeletal regulation / Adhesion","annexin A2","http://www.ncbi.nlm.nih.gov/gene/?term=302","302","12306",null,null,null,"706240","P07355","P07356","A0A8I5ZPN9","A0A8P0S814","A0A286ZJV6","F7H0C6","GO:0005912; GO:1990665; GO:0035578; GO:0005604; GO:0016323; GO:0009986; GO:0062023; GO:0001533; GO:0005737; GO:0005829; GO:0005769; GO:0005768; GO:0070062; GO:0005576; GO:0005615; GO:0031902; GO:0005811; GO:0005765; GO:0042470; GO:0016020; GO:0045121; GO:0030496; GO:0035749; GO:0016363; GO:0005634; GO:1990667; GO:0005886; GO:0098797; GO:0090575; GO:0042383; GO:0043220; GO:0031982","GO:0098641; GO:0005262; GO:0005509; GO:0005544; GO:0048306; GO:0008092; GO:0042802; GO:0005546; GO:0001786; GO:0019834; GO:0004859; GO:0002020; GO:0005515; GO:0003723; GO:0044548; GO:0004867; GO:0046790","GO:0001525; GO:0070588; GO:0098609; GO:0030199; GO:0042730; GO:0001765; GO:0042789; GO:0032804; GO:0002091; GO:0036035; GO:0051099; GO:0045921; GO:1905581; GO:1905597; GO:1905599; GO:1905686; GO:0010756; GO:0001921; GO:1905602; GO:0045944; GO:0044090; GO:0031340; GO:0050767; GO:0006900","PTHR10502:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=537|UniProtKB=P07355"]
["ANXA3",null,"ANXA3","36","rb",null,1,2,"n/a","n/a","n/a","n/a","# 1668",".ANG., .CANCER., .IMU., .IMUR., .OP., .OT., .TRASR.",null,"ANNEXIN A3","animal organ regeneration; defense response to bacterium; hippocampus development; neutrophil degranulation; phagocytosis; positive regulation of angiogenesis; positive regulation of DNA metabolic process; positive regulation of DNA-binding transcription factor activity; positive regulation of endothelial cell migration; response to glucocorticoid; response to growth factor","calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; phospholipase A2 inhibitor activity; phospholipase inhibitor activity","axon; cytoplasm; dendrite; extracellular exosome; membrane; neuronal cell body; phagocytic vesicle membrane; plasma membrane; specific granule",null,"annexin A3","http://www.ncbi.nlm.nih.gov/gene/?term=306","306","11745","25291",null,null,null,"P12429","O35639","P14669","A0A8I3RZ65",null,"A0A1D5R6K0","GO:0030424; GO:0005737; GO:0030425; GO:0070062; GO:0016020; GO:0043025; GO:0030670; GO:0005886; GO:0042581","GO:0005509; GO:0005544; GO:0048306; GO:0019834; GO:0004859","GO:0031100; GO:0042742; GO:0021766; GO:0043312; GO:0006909; GO:0045766; GO:0051054; GO:0051091; GO:0010595; GO:0051384; GO:0070848","PTHR10502:SF25","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=541|UniProtKB=P12429"]
["Apaf-1",null,"APAF1","135","rb",null,2,1.1000000000000001,8,8,1,1,"# 3069",".ALZ., .APO., .CANCER., .CANPTHW., .CD., .CSP., .DI., .FAS., .HEPB., .HIF., .HUNT., .OP., .P53S., .SCLC., .SREME.","p53 pathway; Huntington disease; FAS signaling pathway; Apoptosis signaling pathway","APOPTOTIC PROTEASE-ACTIVATING FACTOR 1","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; apoptotic process; apoptotic signaling pathway; brain development; cardiac muscle cell apoptotic process; cell differentiation; cellular response to transforming growth factor beta stimulus; forebrain development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; kidney development; nervous system development; neural tube closure; neuron apoptotic process; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; regulation of apoptotic DNA fragmentation; regulation of apoptotic process; response to G1 DNA damage checkpoint signaling; response to hypoxia; response to nutrient","ADP binding; ATP binding; cysteine-type endopeptidase activator activity involved in apoptotic process; heat shock protein binding; identical protein binding; nucleotide binding; protein binding","apoptosome; cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; nucleus; protein-containing complex; secretory granule lumen","Apoptosis","apoptotic peptidase activating factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=317","317","11783","78963",null,null,null,"O14727","O88879","Q9EPV5","A0A8I3PSY9","A0A5G2QD50","F6U0K7","GO:0043293; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1904813; GO:0005634; GO:0032991; GO:0034774","GO:0043531; GO:0005524; GO:0008656; GO:0031072; GO:0042802; GO:0000166; GO:0005515","GO:0097202; GO:0006919; GO:0008635; GO:0007568; GO:0006915; GO:0097190; GO:0007420; GO:0010659; GO:0030154; GO:0071560; GO:0030900; GO:0097193; GO:0070059; GO:0001822; GO:0007399; GO:0001843; GO:0051402; GO:0043065; GO:2001235; GO:1902510; GO:0042981; GO:0072432; GO:0001666; GO:0007584","PTHR22845:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=576|UniProtKB=O14727","P00059; P00029; P00020; P00006"]
["APC",null,"APC","310, 160","rb",null,7,4,"n/a","n/a","n/a","n/a","TK # 025",".ALZ., .ANG., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .EMC., .HIPPO., .INS., .MIG., .OP., .OPA., .OT., .SREME., .ST., .WNT.","Angiogenesis; Wnt signaling pathway","ADENOMATOUS POLYPOSIS COLI PROTEIN","bicellular tight junction assembly; cell adhesion; cell fate specification; cell migration; cellular response to DNA damage stimulus; endocardial cushion morphogenesis; heart valve development; insulin receptor signaling pathway; mitotic cytokinesis; mitotic spindle assembly checkpoint signaling; negative regulation of canonical Wnt signaling pathway; negative regulation of cell cycle G1/S phase transition; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of microtubule depolymerization; negative regulation of Wnt signaling pathway; nervous system development; pattern specification process; positive regulation of apoptotic process; positive regulation of cell death; positive regulation of cell migration; positive regulation of cold-induced thermogenesis; positive regulation of protein catabolic process; positive regulation of protein localization to centrosome; positive regulation of pseudopodium assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein-containing complex assembly; regulation of attachment of spindle microtubules to kinetochore; regulation of cell differentiation; regulation of microtubule-based process; Wnt signaling pathway","beta-catenin binding; cadherin binding; dynein complex binding; gamma-catenin binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding; protein kinase regulator activity; ubiquitin protein ligase binding","adherens junction; anchoring junction; beta-catenin destruction complex; bicellular tight junction; catenin complex; cell projection; centrosome; cytoplasm; cytoplasmic microtubule; cytoskeleton; cytosol; Golgi apparatus; kinetochore; lamellipodium; lateral plasma membrane; membrane; microtubule; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle membrane; Wnt signalosome",null,"APC regulator of WNT signaling pathway","http://www.ncbi.nlm.nih.gov/gene/?term=324","324","11789","24205",null,null,null,"P25054","B2RUG9","A0A0G2K8G0","A0A8I3MM67","A0A286ZQ97","A0A1D5Q593","GO:0005912; GO:0070161; GO:0030877; GO:0005923; GO:0016342; GO:0042995; GO:0005813; GO:0005737; GO:0005881; GO:0005856; GO:0005829; GO:0005794; GO:0000776; GO:0030027; GO:0016328; GO:0016020; GO:0005874; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0032587; GO:1990909","GO:0008013; GO:0045296; GO:0070840; GO:0045295; GO:0008017; GO:0051010; GO:0005515; GO:0019901; GO:0019887; GO:0031625","GO:0070830; GO:0007155; GO:0001708; GO:0016477; GO:0006974; GO:0003203; GO:0003170; GO:0008286; GO:0000281; GO:0007094; GO:0090090; GO:1902807; GO:0008285; GO:0045736; GO:2000134; GO:0007026; GO:0030178; GO:0007399; GO:0007389; GO:0043065; GO:0010942; GO:0030335; GO:0120162; GO:0045732; GO:1904781; GO:0031274; GO:0043161; GO:0065003; GO:0051988; GO:0045595; GO:0032886; GO:0016055","PTHR12607:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=583|UniProtKB=P25054","P00005; P00057"]
["APG12L (ATG12)",null,"ATG12","15","rb",null,7,4,7,7,7,7,"# 0617",".APH., .CD., .CSP., .FOXO., .IIR., .IMU., .IMUR., .OP., .OPA., .OT., .TRASR., .VIR.",null,"UBIQUITIN-LIKE PROTEIN ATG12","autophagosome assembly; autophagy; autophagy of mitochondrion; autophagy of nucleus; C-terminal protein lipidation; macroautophagy; negative regulation of defense response to virus; negative regulation of innate immune response; negative regulation of type I interferon production; positive regulation of viral translation; protein lipidation; regulation of autophagosome maturation","protein binding","Atg12-Atg5-Atg16 complex; autophagosome; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; nucleoplasm; phagocytic vesicle membrane; phagophore assembly site membrane; protein-containing complex; transferase complex",null,"autophagy related 12","http://www.ncbi.nlm.nih.gov/gene/?term=9140","9140","67526","361321",null,null,null,"O94817","Q9CQY1","Q2TBJ5",null,null,null,"GO:0034274; GO:0005776; GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005654; GO:0030670; GO:0034045; GO:0032991; GO:1990234","GO:0005515","GO:0000045; GO:0006914; GO:0000422; GO:0044804; GO:0006501; GO:0016236; GO:0050687; GO:0045824; GO:0032480; GO:1904973; GO:0006497; GO:1901096","PTHR13385:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=588|UniProtKB=O94817"]
["APG3L",null,"ATG3","36","rb",null,6,8,8,1,8.1,8.1,"# 0608",".APH., .APO., .CD., .CSP., .OP., .OT., .UBI.",null,"UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3","autophagosome assembly; autophagy; autophagy of mitochondrion; autophagy of nucleus; macroautophagy; metabolic process; mitochondrial fragmentation involved in apoptotic process; negative regulation of phagocytosis; protein targeting to membrane; protein transport; protein ubiquitination; regulation of cilium assembly","Atg12 transferase activity; Atg8 ligase activity; enzyme binding; protein binding; transferase activity; ubiquitin-like protein transferase activity","cytoplasm; cytoplasmic ubiquitin ligase complex; cytosol",null,"autophagy related 3","http://www.ncbi.nlm.nih.gov/gene/?term=64422","64422","67841","171415",null,null,null,"Q9NT62","Q9CPX6","Q6AZ50",null,"A0A5G2QHY9","F7D7B0","GO:0005737; GO:0000153; GO:0005829","GO:0019777; GO:0019776; GO:0019899; GO:0005515; GO:0016740; GO:0019787","GO:0000045; GO:0006914; GO:0000422; GO:0044804; GO:0016236; GO:0008152; GO:0043653; GO:0050765; GO:0006612; GO:0015031; GO:0016567; GO:1902017","PTHR12866:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20962|UniProtKB=Q9NT62"]
["APG4B",null,"ATG4B","44","rb",null,6,7,"n/a","n/a","n/a","n/a","# 0609",".APH., .CD., .CSP.",null,"CYSTEINE PROTEASE ATG4B","autophagy; lysosomal microautophagy; macroautophagy; mitophagy; otolith mineralization completed early in development; protein delipidation; protein localization to phagophore assembly site; protein transport; proteolysis; selective autophagy","Atg8-specific peptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; hydrolase activity; peptidase activity; protein binding; scaffold protein binding","autophagosome; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; mitochondrion",null,"autophagy related 4B cysteine peptidase","http://www.ncbi.nlm.nih.gov/gene/?term=23192","23192",null,"316640",null,null,null,"Q9Y4P1","A0A087WNR6","A0A0G2QC33","A0A8I3PPE0",null,"A0A1D5QWY6","GO:0005776; GO:0005737; GO:0031410; GO:0005829; GO:0005783; GO:0005739","GO:0019786; GO:0004197; GO:0008234; GO:0004175; GO:0016787; GO:0008233; GO:0005515; GO:0097110","GO:0006914; GO:0016237; GO:0016236; GO:0000423; GO:0031173; GO:0051697; GO:0034497; GO:0015031; GO:0006508; GO:0061912","PTHR22624:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20790|UniProtKB=Q9Y4P1"]
["APG7L",null,"ATG7","78","rb",null,2,7,6,6,7,6,"# 0613",".APH., .APO., .CD., .CSP., .IMUR., .OP., .VIR.","Ubiquitin proteasome pathway","UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7","autophagosome assembly; autophagy; autophagy of mitochondrion; cellular response to hyperoxia; cellular response to nitrogen starvation; cellular response to starvation; C-terminal protein lipidation; defense response to virus; late nucleophagy; macroautophagy; piecemeal microautophagy of the nucleus; positive regulation of apoptotic process; positive regulation of protein catabolic process; positive regulation of protein modification process; protein lipidation; protein modification by small protein conjugation; protein transport; regulation of circadian rhythm; rhythmic process","Atg12 activating enzyme activity; Atg8 activating enzyme activity; protein binding; protein homodimerization activity; ubiquitin-like modifier activating enzyme activity","axoneme; cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; phagophore assembly site; secretory granule lumen",null,"autophagy related 7","http://www.ncbi.nlm.nih.gov/gene/?term=10533","10533","74244",null,null,"100462749",null,"O95352","Q9D906","A0A8I6ABP9","A0A8I3MS83","A0A286ZKK7","A0A1D5RA69","GO:0005930; GO:0005737; GO:0005829; GO:0005576; GO:1904813; GO:0000407; GO:0034774","GO:0019778; GO:0019779; GO:0005515; GO:0042803; GO:0008641","GO:0000045; GO:0006914; GO:0000422; GO:0071455; GO:0006995; GO:0009267; GO:0006501; GO:0051607; GO:0044805; GO:0016236; GO:0034727; GO:0043065; GO:0045732; GO:0031401; GO:0006497; GO:0032446; GO:0015031; GO:0042752; GO:0048511","PTHR10953:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16935|UniProtKB=O95352","P00060"]
["apol 1",null,"APOL1","42-35","rb",null,2,7,6,6,6,6,"# 0629",".IIR., .IMUR., .OP.",null,"APOLIPOPROTEIN L1","chloride transmembrane transport; cholesterol metabolic process; cytolysis by host of symbiont cells; innate immune response; lipid metabolic process; lipid transport; lipoprotein metabolic process; steroid metabolic process","chloride channel activity; lipid binding; protein binding","blood microparticle; endoplasmic reticulum lumen; extracellular region; extracellular space; high-density lipoprotein particle; membrane; very-low-density lipoprotein particle",null,"apolipoprotein L1","http://www.ncbi.nlm.nih.gov/gene/?term=8542","8542","245282","503164",null,null,null,"O14791","Q8CCA5","Q5XIB6",null,"A0A287AGI6",null,"GO:0072562; GO:0005788; GO:0005576; GO:0005615; GO:0034364; GO:0016020; GO:0034361","GO:0005254; GO:0008289; GO:0005515","GO:1902476; GO:0008203; GO:0051838; GO:0045087; GO:0006629; GO:0006869; GO:0042157; GO:0008202","PTHR14096:SF55","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=618|UniProtKB=O14791"]
["A-Raf",null,"ARAF","68","rb",null,2,2,2,8,8,8,"# 1859",".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CD., .CML., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .VEGFS.","CCKR signaling map; T cell activation; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","SERINE/THREONINE-PROTEIN KINASE A-RAF","MAPK cascade; negative regulation of apoptotic process; phosphorylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; protein modification process; protein phosphorylation; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling; signal transduction","ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cellular_component; cytosol; mitochondrion","MAPK signaling","A-Raf proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=369","369","11836","64363",null,"397601",null,"P10398","P04627","P14056","A0A8I3Q3R4","O19004","A0A5F7ZQW0","GO:0005575; GO:0005829; GO:0005739","GO:0005524; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0000165; GO:0043066; GO:0016310; GO:0033138; GO:0001934; GO:0036211; GO:0006468; GO:0032434; GO:0032006; GO:0007165","PTHR44329:SF55","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=646|UniProtKB=P10398","P06959; P00053; P00010; P00056; P00036; P00021; P04393; P00034; P00047; P00005; P00018; P00031; P00019"]
["A-Raf - phospho","Ser299","ARAF","68","rb",null,4,4,"n/a","n/a","n/a","n/a","# 3066",".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CD., .CML., .CRC., .CSP., .DI., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .VEGFS.","CCKR signaling map; T cell activation; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","SERINE/THREONINE-PROTEIN KINASE A-RAF","MAPK cascade; negative regulation of apoptotic process; phosphorylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; protein modification process; protein phosphorylation; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling; signal transduction","ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cellular_component; cytosol; mitochondrion","MAPK signaling","A-Raf proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=369","369","11836","64363",null,"397601",null,"P10398","P04627","P14056","A0A8I3Q3R4","O19004","A0A5F7ZQW0","GO:0005575; GO:0005829; GO:0005739","GO:0005524; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0000165; GO:0043066; GO:0016310; GO:0033138; GO:0001934; GO:0036211; GO:0006468; GO:0032434; GO:0032006; GO:0007165","PTHR44329:SF55","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=646|UniProtKB=P10398","P06959; P00053; P00010; P00056; P00036; P00021; P04393; P00034; P00047; P00005; P00018; P00031; P00019"]
["A-Raf - phospho","Tyr301/Tyr302","ARAF","68","rb",null,2,3,3,3,8,8,"# 1844",".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CD., .CML., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .VEGFS.","CCKR signaling map; T cell activation; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","SERINE/THREONINE-PROTEIN KINASE A-RAF","MAPK cascade; negative regulation of apoptotic process; phosphorylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; protein modification process; protein phosphorylation; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling; signal transduction","ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cellular_component; cytosol; mitochondrion",null,"A-Raf proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=369","369","11836","64363",null,"397601",null,"P10398","P04627","P14056","A0A8I3Q3R4","O19004","A0A5F7ZQW0","GO:0005575; GO:0005829; GO:0005739","GO:0005524; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0000165; GO:0043066; GO:0016310; GO:0033138; GO:0001934; GO:0036211; GO:0006468; GO:0032434; GO:0032006; GO:0007165","PTHR44329:SF55","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=646|UniProtKB=P10398","P06959; P00053; P00010; P00056; P00036; P00021; P04393; P00034; P00047; P00005; P00018; P00031; P00019"]
["ARF1",null,"ARF1","21","ms",null,2,2,7,7,2,2.1,"# 1362",".CSP., .DI., .HUNT., .IMUR., .INT., .OP., .OPA., .VIR.","Huntington disease; Integrin signalling pathway","ADP-RIBOSYLATION FACTOR 1","cellular copper ion homeostasis; cellular response to virus; dendritic spine organization; intracellular protein transport; long-term synaptic depression; mitotic cleavage furrow ingression; protein transport; regulation of Arp2/3 complex-mediated actin nucleation; regulation of receptor internalization; vesicle-mediated transport","GTP binding; GTPase activity; hydrolase activity; magnesium ion binding; nucleotide binding; protein binding; protein domain specific binding; RNA binding","cell leading edge; cytoplasm; cytosol; endomembrane system; extracellular exosome; focal adhesion; Golgi apparatus; Golgi membrane; membrane; neuron projection; plasma membrane; postsynaptic density; protein-containing complex; sarcomere; synapse","Transport","ADP ribosylation factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=375","375","11840","64310",null,null,null,"P84077","P84078","P84079","A0A8P0SSM0","A0A286ZTI3",null,"GO:0031252; GO:0005737; GO:0005829; GO:0012505; GO:0070062; GO:0005925; GO:0005794; GO:0000139; GO:0016020; GO:0043005; GO:0005886; GO:0014069; GO:0032991; GO:0030017; GO:0045202","GO:0005525; GO:0003924; GO:0016787; GO:0000287; GO:0000166; GO:0005515; GO:0019904; GO:0003723","GO:0006878; GO:0098586; GO:0097061; GO:0006886; GO:0060292; GO:1990386; GO:0015031; GO:0034315; GO:0002090; GO:0016192","PTHR11711:SF357","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=652|UniProtKB=P84077","P00029; P00034"]
["Arginase-1",null,"ARG1","40","rb",null,2,1,1,1,1,1,"# 1120",".CCP., .CP., .CSP., .DRR., .IIR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .OP., .OT., .OXS., .SREME.",null,"ARGINASE-1","adaptive immune response; aging; arginine catabolic process; arginine catabolic process to ornithine; arginine metabolic process; cellular response to dexamethasone stimulus; cellular response to glucagon stimulus; cellular response to hydrogen peroxide; cellular response to interleukin-4; cellular response to lipopolysaccharide; cellular response to transforming growth factor beta stimulus; collagen biosynthetic process; defense response to protozoan; female pregnancy; immune system process; innate immune response; liver development; lung development; mammary gland involution; maternal process involved in female pregnancy; negative regulation of activated T cell proliferation; negative regulation of T cell proliferation; negative regulation of T-helper 2 cell cytokine production; negative regulation of type II interferon-mediated signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of neutrophil mediated killing of fungus; regulation of L-arginine import across plasma membrane; response to amine; response to amino acid; response to axon injury; response to cadmium ion; response to herbicide; response to lipopolysaccharide; response to manganese ion; response to methylmercury; response to peptide hormone; response to selenium ion; response to steroid hormone; response to vitamin A; response to vitamin E; response to wounding; response to xenobiotic stimulus; response to zinc ion; urea cycle","arginase activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; identical protein binding; manganese ion binding; metal ion binding; protein binding","azurophil granule lumen; cytoplasm; cytosol; extracellular region; extracellular space; mitochondrial outer membrane; neuron projection; neuronal cell body; nucleus; specific granule lumen",null,"arginase 1","http://www.ncbi.nlm.nih.gov/gene/?term=383","383","11846",null,"474823","397115","710410","P05089","Q61176","A0A8L2Q8Y7","A0A8P0S6E0","Q95JC8","A0A5F8AE86","GO:0035578; GO:0005737; GO:0005829; GO:0005576; GO:0005615; GO:0005741; GO:0043005; GO:0043025; GO:0005634; GO:0035580","GO:0004053; GO:0016787; GO:0016813; GO:0042802; GO:0030145; GO:0046872; GO:0005515","GO:0002250; GO:0007568; GO:0006527; GO:0019547; GO:0006525; GO:0071549; GO:0071377; GO:0070301; GO:0071353; GO:0071222; GO:0071560; GO:0032964; GO:0042832; GO:0007565; GO:0002376; GO:0045087; GO:0001889; GO:0030324; GO:0060056; GO:0060135; GO:0046007; GO:0042130; GO:2000552; GO:0060336; GO:0001938; GO:0070965; GO:1905541; GO:0014075; GO:0043200; GO:0048678; GO:0046686; GO:0009635; GO:0032496; GO:0010042; GO:0051597; GO:0043434; GO:0010269; GO:0048545; GO:0033189; GO:0033197; GO:0009611; GO:0009410; GO:0010043; GO:0000050","PTHR43782:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=663|UniProtKB=P05089"]
["Arginase-2",null,"ARG2","40","rb",null,1,8,"n/a","n/a","n/a","n/a","# 3286",".IIR., .IMU., .IMUR., .OP., .OT., .TRASR.",null,"ARGINASE-2, MITOCHONDRIAL","adaptive immune response; arginine catabolic process to ornithine; arginine metabolic process; immune system process; innate immune response; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process; negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of chemokine (C-C motif) ligand 4 production; negative regulation of chemokine (C-C motif) ligand 5 production; negative regulation of defense response to bacterium; negative regulation of interleukin-13 production; negative regulation of interleukin-17 production; negative regulation of macrophage inflammatory protein 1 alpha production; negative regulation of tumor necrosis factor production; negative regulation of type 2 immune response; nitric oxide biosynthetic process; positive regulation of cellular senescence; regulation of interleukin-1 beta production; regulation of reactive oxygen species biosynthetic process; striated muscle contraction; urea cycle; ureteric bud development","arginase activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; manganese ion binding; metal ion binding; protein binding","cytoplasm; mitochondrial matrix; mitochondrion",null,"arginase 2","http://www.ncbi.nlm.nih.gov/gene/?term=384","384","11847",null,"480364","100155893",null,"P78540","O08691","A0A8I6AM02","A0A8I3MI74","F1SA26","A0A1D5Q1Z8","GO:0005737; GO:0005759; GO:0005739","GO:0004053; GO:0016787; GO:0016813; GO:0030145; GO:0046872; GO:0005515","GO:0002250; GO:0019547; GO:0006525; GO:0002376; GO:0045087; GO:1905403; GO:2000562; GO:0071644; GO:0071650; GO:1900425; GO:0032696; GO:0032700; GO:0071641; GO:0032720; GO:0002829; GO:0006809; GO:2000774; GO:0032651; GO:1903426; GO:0006941; GO:0000050; GO:0001657","PTHR43782:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=664|UniProtKB=P78540"]
["Arrestin beta-1",null,"ARRB1","51","rb",null,1,8,"n/a","n/a","n/a","n/a","# 3064",".CSP., .DEV., .GPCR., .GPROT., .HHSP., .IMUF., .INFM., .MAPK., .NOTCH., .OP., .OPA., .OT., .RAS., .RTK., .ST., .TRASR., .UBI., .WNT.","Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","BETA-ARRESTIN-1","G protein-coupled receptor internalization; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; negative regulation of protein ubiquitination; negative regulation of signal transduction; positive regulation of ERK1 and ERK2 cascade; positive regulation of histone acetylation; positive regulation of histone H4 acetylation; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of Rho protein signal transduction; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein transport; protein ubiquitination; regulation of transcription by RNA polymerase II; signal transduction; stress fiber assembly; ubiquitin-dependent protein catabolic process","angiotensin receptor binding; arrestin family protein binding; enzyme inhibitor activity; G protein-coupled receptor binding; GTPase activator activity; histone acetyltransferase activity; insulin-like growth factor receptor binding; protein binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding","cell projection; chromatin; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; Golgi membrane; lysosomal membrane; membrane; nuclear body; nucleoplasm; nucleus; plasma membrane; pseudopodium",null,"arrestin beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=408","408","109689","25387",null,"100521141",null,"P49407","Q8BWG8","A0A8I6G7K6","A0A8I3NA76","A0A286ZND1","A0A5F7ZWP7","GO:0042995; GO:0000785; GO:0005905; GO:0005737; GO:0031410; GO:0030659; GO:0005829; GO:0000139; GO:0005765; GO:0016020; GO:0016604; GO:0005654; GO:0005634; GO:0005886; GO:0031143","GO:0031701; GO:1990763; GO:0004857; GO:0001664; GO:0005096; GO:0004402; GO:0005159; GO:0005515; GO:0003713; GO:0008134; GO:0031625","GO:0002031; GO:0032715; GO:0032717; GO:0032088; GO:0045746; GO:0031397; GO:0009968; GO:0070374; GO:0035066; GO:0090240; GO:0001934; GO:0002092; GO:0035025; GO:0045944; GO:0043161; GO:0015031; GO:0016567; GO:0006357; GO:0007165; GO:0043149; GO:0006511","PTHR11792:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=711|UniProtKB=P49407","P05911; P00026; P00031; P00057"]
["Arrestin beta-1 - phospho","Ser412","ARRB1","50","ms",null,1,8,"n/a","n/a","n/a","n/a","# 3062",".CSP., .DEV., .GPCR., .GPROT., .HHSP., .IMUF., .INFM., .MAPK., .NOTCH., .OP., .OPA., .OT., .RAS., .RTK., .ST., .TRASR., .UBI., .WNT.","Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","BETA-ARRESTIN-1","G protein-coupled receptor internalization; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; negative regulation of protein ubiquitination; negative regulation of signal transduction; positive regulation of ERK1 and ERK2 cascade; positive regulation of histone acetylation; positive regulation of histone H4 acetylation; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of Rho protein signal transduction; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein transport; protein ubiquitination; regulation of transcription by RNA polymerase II; signal transduction; stress fiber assembly; ubiquitin-dependent protein catabolic process","angiotensin receptor binding; arrestin family protein binding; enzyme inhibitor activity; G protein-coupled receptor binding; GTPase activator activity; histone acetyltransferase activity; insulin-like growth factor receptor binding; protein binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding","cell projection; chromatin; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; Golgi membrane; lysosomal membrane; membrane; nuclear body; nucleoplasm; nucleus; plasma membrane; pseudopodium",null,"arrestin beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=408","408","109689","25387",null,"100521141",null,"P49407","Q8BWG8","A0A8I6G7K6","A0A8I3NA76","A0A286ZND1","A0A5F7ZWP7","GO:0042995; GO:0000785; GO:0005905; GO:0005737; GO:0031410; GO:0030659; GO:0005829; GO:0000139; GO:0005765; GO:0016020; GO:0016604; GO:0005654; GO:0005634; GO:0005886; GO:0031143","GO:0031701; GO:1990763; GO:0004857; GO:0001664; GO:0005096; GO:0004402; GO:0005159; GO:0005515; GO:0003713; GO:0008134; GO:0031625","GO:0002031; GO:0032715; GO:0032717; GO:0032088; GO:0045746; GO:0031397; GO:0009968; GO:0070374; GO:0035066; GO:0090240; GO:0001934; GO:0002092; GO:0035025; GO:0045944; GO:0043161; GO:0015031; GO:0016567; GO:0006357; GO:0007165; GO:0043149; GO:0006511","PTHR11792:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=711|UniProtKB=P49407","P05911; P00026; P00031; P00057"]
["Arrestin beta-2",null,"ARRB2","50","rb",null,1,8,"n/a","n/a","n/a","n/a","# 3063",".APO., .CCKR., .CD., .CSP., .DEV., .GPCR., .GPROT., .HHSP., .IMUF., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TGFB., .TOLL., .TRASR., .UBI., .WNT.","CCKR signaling map; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","BETA-ARRESTIN-2","adult walking behavior; brain development; cell chemotaxis; desensitization of G protein-coupled receptor signaling pathway by arrestin; detection of temperature stimulus involved in sensory perception of pain; dopamine receptor signaling pathway; endocytosis; excitatory postsynaptic potential; follicle-stimulating hormone signaling pathway; G protein-coupled receptor internalization; G protein-coupled receptor signaling pathway; modulation of chemical synaptic transmission; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of GTPase activity; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of neuron apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein kinase B signaling; negative regulation of protein phosphorylation; negative regulation of protein ubiquitination; negative regulation of release of cytochrome c from mitochondria; negative regulation of signal transduction; negative regulation of smooth muscle cell apoptotic process; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of calcium ion transport; positive regulation of cardiac muscle cell differentiation; positive regulation of collagen biosynthetic process; positive regulation of DNA biosynthetic process; positive regulation of epithelial cell apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of synaptic transmission, dopaminergic; postsynaptic signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; protein transport; protein ubiquitination; receptor internalization; regulation of G protein-coupled receptor signaling pathway; regulation of protein phosphorylation; signal transduction; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway","14-3-3 protein binding; alpha-1A adrenergic receptor binding; alpha-1B adrenergic receptor binding; angiotensin receptor binding; arrestin family protein binding; D1 dopamine receptor binding; enzyme binding; follicle-stimulating hormone receptor binding; G protein-coupled receptor binding; identical protein binding; mitogen-activated protein kinase binding; platelet activating factor receptor binding; protein binding; protein domain specific binding; protein kinase B binding; protein-containing complex binding; signaling receptor binding; type 1 angiotensin receptor binding; type 2A serotonin receptor binding; ubiquitin protein ligase binding","basolateral plasma membrane; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; endocytic vesicle; endosome; glutamatergic synapse; membrane; nucleoplasm; nucleus; plasma membrane; postsynaptic density; postsynaptic membrane",null,"arrestin beta 2","http://www.ncbi.nlm.nih.gov/gene/?term=409","409","216869",null,null,null,"709399","P32121","Q91YI4","A0A8I6APG4","A0A8P0NHC5","A0A287A233","A0A5F7ZE43","GO:0016323; GO:0005905; GO:0005737; GO:0031410; GO:0005829; GO:0043197; GO:0030139; GO:0005768; GO:0098978; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0014069; GO:0045211","GO:0071889; GO:0031691; GO:0031692; GO:0031701; GO:1990763; GO:0031748; GO:0019899; GO:0031762; GO:0001664; GO:0042802; GO:0051019; GO:0031859; GO:0005515; GO:0019904; GO:0043422; GO:0044877; GO:0005102; GO:0031702; GO:0031826; GO:0031625","GO:0007628; GO:0007420; GO:0060326; GO:0002032; GO:0050965; GO:0007212; GO:0006897; GO:0060079; GO:0042699; GO:0002031; GO:0007186; GO:0050804; GO:0043154; GO:0034260; GO:0032691; GO:0032695; GO:0032715; GO:0045953; GO:0043524; GO:0032088; GO:0051898; GO:0001933; GO:0031397; GO:0090201; GO:0009968; GO:0034392; GO:0034122; GO:0032720; GO:0051928; GO:2000727; GO:0032967; GO:2000573; GO:1904037; GO:0070374; GO:0010628; GO:0033138; GO:0050731; GO:0051897; GO:0001934; GO:0002092; GO:0032226; GO:0098926; GO:0043161; GO:0015031; GO:0016567; GO:0031623; GO:0008277; GO:0001932; GO:0007165; GO:0006366; GO:0007179","PTHR11792:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=712|UniProtKB=P32121","P06959; P05911; P00026; P00031; P00057"]
["ASC (PYCARD)",null,"PYCARD","22","ms",null,2,1.1000000000000001,1.1000000000000001,4,4,4,"# 1620",".APH., .APO., .CD., .CSP., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .P53S., .RTK., .SREME., .ST., .TCR., .TNF., .TRASR., .VIR.",null,"APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of innate immune response; apoptotic process; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; defense response to other organism; defense response to virus; icosanoid biosynthetic process; immune system process; inflammatory response; innate immune response; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; macropinocytosis; myeloid dendritic cell activation; myeloid dendritic cell activation involved in immune response; negative regulation of cytokine production involved in inflammatory response; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of interferon-beta production; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein serine/threonine kinase activity; NLRP3 inflammasome complex assembly; osmosensory signaling pathway; pattern recognition receptor signaling pathway; positive regulation of actin filament polymerization; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of apoptotic process; positive regulation of chemokine production; positive regulation of cysteine-type endopeptidase activity; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of defense response to virus by host; positive regulation of DNA-binding transcription factor activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of inflammatory response; positive regulation of interleukin-1 beta production; positive regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of macrophage cytokine production; positive regulation of NF-kappaB transcription factor activity; positive regulation of phagocytosis; positive regulation of release of cytochrome c from mitochondria; positive regulation of T cell activation; positive regulation of T cell migration; positive regulation of tumor necrosis factor production; positive regulation of type II interferon production; protein homooligomerization; pyroptosis; regulation of apoptotic process; regulation of autophagy; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of GTPase activity; regulation of inflammatory response; regulation of intrinsic apoptotic signaling pathway; regulation of protein stability; regulation of response to stimulus; regulation of tumor necrosis factor-mediated signaling pathway; response to bacterium; signal transduction; tumor necrosis factor-mediated signaling pathway","BMP receptor binding; cysteine-type endopeptidase activator activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic process; enzyme binding; identical protein binding; interleukin-6 receptor binding; myosin I binding; protease binding; protein binding; protein dimerization activity; protein homodimerization activity; Pyrin domain binding; transmembrane transporter binding; tropomyosin binding","AIM2 inflammasome complex; azurophil granule lumen; cytoplasm; cytosol; endoplasmic reticulum; extracellular region; Golgi apparatus; Golgi membrane; IkappaB kinase complex; inflammasome complex; membrane; microtubule; mitochondrion; neuronal cell body; NLRP1 inflammasome complex; NLRP3 inflammasome complex; NLRP6 inflammasome complex; nucleolus; nucleoplasm; nucleus; protein-containing complex; secretory granule lumen","Apoptosis","PYD and CARD domain containing","http://www.ncbi.nlm.nih.gov/gene/?term=29108","29108","66824",null,"100856347",null,null,"Q9ULZ3","Q9EPB4","G3V8L1","A0A8I3RYZ8",null,null,"GO:0097169; GO:0035578; GO:0005737; GO:0005829; GO:0005783; GO:0005576; GO:0005794; GO:0000139; GO:0008385; GO:0061702; GO:0016020; GO:0005874; GO:0005739; GO:0043025; GO:0072558; GO:0072559; GO:0140738; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0034774","GO:0070700; GO:0008656; GO:0097153; GO:0019899; GO:0042802; GO:0005138; GO:0017024; GO:0002020; GO:0005515; GO:0046983; GO:0042803; GO:0032090; GO:0044325; GO:0005523","GO:0097202; GO:0006919; GO:0002218; GO:0006915; GO:0071347; GO:0071222; GO:0071356; GO:0050829; GO:0050830; GO:0098542; GO:0051607; GO:0046456; GO:0002376; GO:0006954; GO:0045087; GO:0072332; GO:0042771; GO:0044351; GO:0001773; GO:0002277; GO:1900016; GO:0043124; GO:0032688; GO:0032088; GO:0071901; GO:0044546; GO:0007231; GO:0002221; GO:0030838; GO:0042104; GO:0002821; GO:0002588; GO:0043065; GO:0032722; GO:2001056; GO:0043280; GO:0002230; GO:0051091; GO:0070374; GO:2001238; GO:0050729; GO:0032731; GO:0032733; GO:0032755; GO:0032757; GO:0046330; GO:0060907; GO:0051092; GO:0050766; GO:0090200; GO:0050870; GO:2000406; GO:0032760; GO:0032729; GO:0051260; GO:0070269; GO:0042981; GO:0010506; GO:0043281; GO:0043087; GO:0050727; GO:2001242; GO:0031647; GO:0048583; GO:0010803; GO:0009617; GO:0007165; GO:0033209","PTHR46985:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16608|UniProtKB=Q9ULZ3"]
["ASCL2/Mash2",null,"ASCL2","20","sheep",null,4,7,"n/a","n/a","n/a","n/a","# 2802",".CCP., .CP., .CSP., .HIF., .OP., .OT., .SREME., .TRASR.",null,"ACHAETE-SCUTE HOMOLOG 2","cell differentiation; in utero embryonic development; negative regulation of Schwann cell proliferation; negative regulation of transcription by RNA polymerase II; nervous system development; neuron differentiation; placenta development; positive regulation of transcription by RNA polymerase II; regulation of neurogenesis; regulation of transcription by RNA polymerase II; response to hypoxia; sensory organ development; somatic stem cell population maintenance; spongiotrophoblast differentiation; spongiotrophoblast layer development","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; cytoplasm; nucleus; RNA polymerase II transcription regulator complex",null,"achaete-scute family bHLH transcription factor 2","http://www.ncbi.nlm.nih.gov/gene/?term=430","430","17173","24209","483666",null,null,"Q99929","O35885","P19360","A0A8I3N954",null,"F7BGV6","GO:0000785; GO:0005737; GO:0005634; GO:0090575","GO:0003677; GO:0003700; GO:0000981; GO:0001227; GO:0070888; GO:0046983; GO:0000978; GO:0000977; GO:0043565; GO:1990837","GO:0030154; GO:0001701; GO:0010626; GO:0000122; GO:0007399; GO:0030182; GO:0001890; GO:0045944; GO:0050767; GO:0006357; GO:0001666; GO:0007423; GO:0035019; GO:0060708; GO:0060712","PTHR13935:SF62","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=739|UniProtKB=Q99929"]
["ASIC3",null,"ASIC3","59","rb",null,2,2,1,3,2,2,"# 1616",".CSP., .OPA., .ST.",null,"ACID-SENSING ION CHANNEL 3","cation transport; detection of chemical stimulus involved in sensory perception; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception; detection of temperature stimulus involved in sensory perception of pain; enterobactin transport; establishment of localization in cell; inorganic cation transmembrane transport; ion transmembrane transport; ion transport; response to acidic pH; response to heat; response to mechanical stimulus; sensory perception; sensory perception of sour taste; signal transduction; sodium ion transmembrane transport; sodium ion transport","acid-sensing ion channel activity; cation channel activity; enterobactin transmembrane transporter activity; ligand-gated sodium channel activity; sodium channel activity","cytoplasm; membrane; perinuclear region of cytoplasm; plasma membrane","Cation channel","acid sensing ion channel subunit 3","http://www.ncbi.nlm.nih.gov/gene/?term=9311","9311","171209","286920",null,null,null,"Q9UHC3","Q6X1Y6","O35240","A0A8I3N726","I3L578","F6W6L6","GO:0005737; GO:0016020; GO:0048471; GO:0005886","GO:0044736; GO:0005261; GO:0042931; GO:0015280; GO:0005272","GO:0006812; GO:0050907; GO:0050968; GO:0050974; GO:0050966; GO:0050961; GO:0050965; GO:0042930; GO:0051649; GO:0098662; GO:0034220; GO:0006811; GO:0010447; GO:0009408; GO:0009612; GO:0007600; GO:0050915; GO:0007165; GO:0035725; GO:0006814","PTHR11690:SF228","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=101|UniProtKB=Q9UHC3"]
["ASK1",null,"MAP3K5","155","rb",null,7,8,7,8,8,1,"# 1318",".ALZ., .APO., .CCP., .CD., .CP., .CSP., .DI., .EGFR., .FAS., .FGFR., .HUNT., .IIR., .IMU., .IMUR., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .RTK., .SREME., .ST., .TNF., .TRASR.","p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Integrin signalling pathway; EGF receptor signaling pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5","apoptotic process; apoptotic signaling pathway; cellular response to amino acid starvation; cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cellular response to tumor necrosis factor; cellular senescence; endothelial cell apoptotic process; immune system process; innate immune response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; JNK cascade; MAPK cascade; p38MAPK cascade; phosphorylation; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA-templated transcription; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; positive regulation of neuron death; positive regulation of p38MAPK cascade; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of vascular associated smooth muscle cell proliferation; programmed necrotic cell death; protein phosphorylation; regulation of cell death; response to endoplasmic reticulum stress; response to ischemia; stress-activated MAPK cascade; wound healing","ATP binding; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endoplasmic reticulum; external side of plasma membrane; IRE1-TRAF2-ASK1 complex; protein kinase complex; protein-containing complex",null,"mitogen-activated protein kinase kinase kinase 5","http://www.ncbi.nlm.nih.gov/gene/?term=4217","4217","26408",null,"476215",null,null,"Q99683","O35099","A0A8I6A280","A0A8I3RT53","A0A286ZRB9","A0A1D5QZ26","GO:0005737; GO:0005829; GO:0005783; GO:0009897; GO:1990604; GO:1902911; GO:0032991","GO:0005524; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0019904; GO:0042803; GO:0004672; GO:0019901; GO:0019903; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:0097190; GO:0034198; GO:0070301; GO:1902170; GO:0071356; GO:0090398; GO:0072577; GO:0002376; GO:0045087; GO:0070059; GO:0008631; GO:0007254; GO:0000165; GO:0038066; GO:0016310; GO:0043065; GO:0010666; GO:0043280; GO:0045893; GO:0046330; GO:0043507; GO:0043410; GO:0045663; GO:1901216; GO:1900745; GO:0045860; GO:0001934; GO:1904707; GO:0097300; GO:0006468; GO:0010941; GO:0034976; GO:0002931; GO:0051403; GO:0042060","PTHR11584:SF332","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6857|UniProtKB=Q99683","P05918; P06664; P00021; P00034; P00018; P00020; P00006"]
["ASK1 - phospho","Ser83","MAP3K5","155","rb",null,7,4,4,4,7,4,"# 1323",".ALZ., .APO., .CCP., .CD., .CP., .CSP., .DI., .EGFR., .FAS., .FGFR., .HUNT., .IIR., .IMU., .IMUR., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .RTK., .SREME., .ST., .TNF., .TRASR.","p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Integrin signalling pathway; EGF receptor signaling pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5","apoptotic process; apoptotic signaling pathway; cellular response to amino acid starvation; cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cellular response to tumor necrosis factor; cellular senescence; endothelial cell apoptotic process; immune system process; innate immune response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; JNK cascade; MAPK cascade; p38MAPK cascade; phosphorylation; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA-templated transcription; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; positive regulation of neuron death; positive regulation of p38MAPK cascade; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of vascular associated smooth muscle cell proliferation; programmed necrotic cell death; protein phosphorylation; regulation of cell death; response to endoplasmic reticulum stress; response to ischemia; stress-activated MAPK cascade; wound healing","ATP binding; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endoplasmic reticulum; external side of plasma membrane; IRE1-TRAF2-ASK1 complex; protein kinase complex; protein-containing complex",null,"mitogen-activated protein kinase kinase kinase 5","http://www.ncbi.nlm.nih.gov/gene/?term=4217","4217","26408",null,"476215",null,null,"Q99683","O35099","A0A8I6A280","A0A8I3RT53","A0A286ZRB9","A0A1D5QZ26","GO:0005737; GO:0005829; GO:0005783; GO:0009897; GO:1990604; GO:1902911; GO:0032991","GO:0005524; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0019904; GO:0042803; GO:0004672; GO:0019901; GO:0019903; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:0097190; GO:0034198; GO:0070301; GO:1902170; GO:0071356; GO:0090398; GO:0072577; GO:0002376; GO:0045087; GO:0070059; GO:0008631; GO:0007254; GO:0000165; GO:0038066; GO:0016310; GO:0043065; GO:0010666; GO:0043280; GO:0045893; GO:0046330; GO:0043507; GO:0043410; GO:0045663; GO:1901216; GO:1900745; GO:0045860; GO:0001934; GO:1904707; GO:0097300; GO:0006468; GO:0010941; GO:0034976; GO:0002931; GO:0051403; GO:0042060","PTHR11584:SF332","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6857|UniProtKB=Q99683","P05918; P06664; P00021; P00034; P00018; P00020; P00006"]
["ASK1 - phospho","Ser967","MAP3K5","155","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1313",".ALZ., .APO., .CCP., .CD., .CP., .CSP., .DI., .EGFR., .FAS., .FGFR., .HUNT., .IIR., .IMU., .IMUR., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .RTK., .SREME., .ST., .TNF., .TRASR.","p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Integrin signalling pathway; EGF receptor signaling pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5","apoptotic process; apoptotic signaling pathway; cellular response to amino acid starvation; cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cellular response to tumor necrosis factor; cellular senescence; endothelial cell apoptotic process; immune system process; innate immune response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; JNK cascade; MAPK cascade; p38MAPK cascade; phosphorylation; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA-templated transcription; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; positive regulation of neuron death; positive regulation of p38MAPK cascade; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of vascular associated smooth muscle cell proliferation; programmed necrotic cell death; protein phosphorylation; regulation of cell death; response to endoplasmic reticulum stress; response to ischemia; stress-activated MAPK cascade; wound healing","ATP binding; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endoplasmic reticulum; external side of plasma membrane; IRE1-TRAF2-ASK1 complex; protein kinase complex; protein-containing complex",null,"mitogen-activated protein kinase kinase kinase 5","http://www.ncbi.nlm.nih.gov/gene/?term=4217","4217","26408",null,"476215",null,null,"Q99683","O35099","A0A8I6A280","A0A8I3RT53","A0A286ZRB9","A0A1D5QZ26","GO:0005737; GO:0005829; GO:0005783; GO:0009897; GO:1990604; GO:1902911; GO:0032991","GO:0005524; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0019904; GO:0042803; GO:0004672; GO:0019901; GO:0019903; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:0097190; GO:0034198; GO:0070301; GO:1902170; GO:0071356; GO:0090398; GO:0072577; GO:0002376; GO:0045087; GO:0070059; GO:0008631; GO:0007254; GO:0000165; GO:0038066; GO:0016310; GO:0043065; GO:0010666; GO:0043280; GO:0045893; GO:0046330; GO:0043507; GO:0043410; GO:0045663; GO:1901216; GO:1900745; GO:0045860; GO:0001934; GO:1904707; GO:0097300; GO:0006468; GO:0010941; GO:0034976; GO:0002931; GO:0051403; GO:0042060","PTHR11584:SF332","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6857|UniProtKB=Q99683","P05918; P06664; P00021; P00034; P00018; P00020; P00006"]
["ASK1 - phospho","Thr845","MAP3K5","155","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1320",".ALZ., .APO., .CCP., .CD., .CP., .CSP., .DI., .EGFR., .FAS., .FGFR., .HUNT., .IIR., .IMU., .IMUR., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .RTK., .SREME., .ST., .TNF., .TRASR.","p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Integrin signalling pathway; EGF receptor signaling pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5","apoptotic process; apoptotic signaling pathway; cellular response to amino acid starvation; cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cellular response to tumor necrosis factor; cellular senescence; endothelial cell apoptotic process; immune system process; innate immune response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; JNK cascade; MAPK cascade; p38MAPK cascade; phosphorylation; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA-templated transcription; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; positive regulation of neuron death; positive regulation of p38MAPK cascade; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of vascular associated smooth muscle cell proliferation; programmed necrotic cell death; protein phosphorylation; regulation of cell death; response to endoplasmic reticulum stress; response to ischemia; stress-activated MAPK cascade; wound healing","ATP binding; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endoplasmic reticulum; external side of plasma membrane; IRE1-TRAF2-ASK1 complex; protein kinase complex; protein-containing complex",null,"mitogen-activated protein kinase kinase kinase 5","http://www.ncbi.nlm.nih.gov/gene/?term=4217","4217","26408",null,"476215",null,null,"Q99683","O35099","A0A8I6A280","A0A8I3RT53","A0A286ZRB9","A0A1D5QZ26","GO:0005737; GO:0005829; GO:0005783; GO:0009897; GO:1990604; GO:1902911; GO:0032991","GO:0005524; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0019904; GO:0042803; GO:0004672; GO:0019901; GO:0019903; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:0097190; GO:0034198; GO:0070301; GO:1902170; GO:0071356; GO:0090398; GO:0072577; GO:0002376; GO:0045087; GO:0070059; GO:0008631; GO:0007254; GO:0000165; GO:0038066; GO:0016310; GO:0043065; GO:0010666; GO:0043280; GO:0045893; GO:0046330; GO:0043507; GO:0043410; GO:0045663; GO:1901216; GO:1900745; GO:0045860; GO:0001934; GO:1904707; GO:0097300; GO:0006468; GO:0010941; GO:0034976; GO:0002931; GO:0051403; GO:0042060","PTHR11584:SF332","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6857|UniProtKB=Q99683","P05918; P06664; P00021; P00034; P00018; P00020; P00006"]
["ASL (argininosuccinate lyase)",null,"ASL","52","rb",null,1,2,2,1,1,1,"# 1150",null,"Arginine biosynthesis","ARGININOSUCCINATE LYASE","amino acid biosynthetic process; amino acid metabolic process; ammonia assimilation cycle; arginine biosynthetic process; arginine biosynthetic process via ornithine; arginine metabolic process; locomotory behavior; positive regulation of nitric oxide biosynthetic process; post-embryonic development; small molecule metabolic process; urea cycle","argininosuccinate lyase activity; catalytic activity; identical protein binding; lyase activity; protein binding","cytoplasm; cytosol; extracellular exosome","Amino acid biosynthesis","argininosuccinate lyase","http://www.ncbi.nlm.nih.gov/gene/?term=435","435",null,null,null,null,null,"P04424",null,null,null,"A0A287AEG5","A0A1D5Q428","GO:0005737; GO:0005829; GO:0070062","GO:0004056; GO:0003824; GO:0042802; GO:0016829; GO:0005515","GO:0008652; GO:0006520; GO:0019676; GO:0006526; GO:0042450; GO:0006525; GO:0007626; GO:0045429; GO:0009791; GO:0044281; GO:0000050","PTHR43814:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=746|UniProtKB=P04424","P02728"]
["ATF3",null,"ATF3","21","rb",null,2,4,5,8,7,8,"# 1353",".APO., .CCP., .CD., .CP., .CSP., .MAPK., .OP., .OPA., .OT., .RTK., .ST., .TRASR.","Gonadotropin releasing hormone receptor pathway; Apoptosis signaling pathway","CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3","cellular response to amino acid starvation; endoplasmic reticulum unfolded protein response; gluconeogenesis; negative regulation of DNA-templated transcription; negative regulation of ERK1 and ERK2 cascade; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of TRAIL-activated apoptotic signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance; response to organic substance; skeletal muscle cell differentiation","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","CHOP-ATF3 complex; chromatin; nucleolus; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex",null,"activating transcription factor 3","http://www.ncbi.nlm.nih.gov/gene/?term=467","467","11910","25389",null,null,"710832","P18847","Q60765","P29596",null,"A0A5G2QU89","F7GUS9","GO:1990622; GO:0000785; GO:0005730; GO:0005654; GO:0005634; GO:0090575","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0042802; GO:0005515; GO:0046982; GO:0042803; GO:0000978; GO:0000977; GO:1990837; GO:0000976","GO:0034198; GO:0030968; GO:0006094; GO:0045892; GO:0070373; GO:0000122; GO:0008284; GO:0010628; GO:1903984; GO:0045944; GO:1990440; GO:0006355; GO:0006357; GO:0061394; GO:0010033; GO:0035914","PTHR23351:SF23","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=785|UniProtKB=P18847","P06664; P00006"]
["ATF4",null,"ATF4","40","gt",null,2,6,6,6,6,6,"# 0725",".ALZ., .APH., .APO., .CANCER., .CD., .CSP., .DI., .GPCR., .GPROT., .HEPB., .MAPK., .OP., .OPA., .OT., .OXS., .PI3K., .PRC., .RTK., .SREME., .ST., .TNF., .TRASR.","Apoptosis signaling pathway","CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4","bone mineralization; cellular calcium ion homeostasis; cellular response to amino acid starvation; cellular response to dopamine; cellular response to glucose starvation; cellular response to leucine starvation; cellular response to oxidative stress; cellular response to oxygen-glucose deprivation; cellular response to UV; circadian regulation of gene expression; circadian rhythm; embryonic hemopoiesis; endoplasmic reticulum unfolded protein response; gamma-aminobutyric acid signaling pathway; gluconeogenesis; HRI-mediated signaling; integrated stress response signaling; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; L-asparagine metabolic process; lens fiber cell morphogenesis; mRNA transcription by RNA polymerase II; negative regulation of cold-induced thermogenesis; negative regulation of oxidative stress-induced neuron death; negative regulation of potassium ion transport; negative regulation of transcription by RNA polymerase II; negative regulation of translational initiation in response to stress; neuron differentiation; PERK-mediated unfolded protein response; positive regulation of apoptotic process; positive regulation of biomineral tissue development; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of sodium-dependent phosphate transport; positive regulation of transcription by RNA polymerase I; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; positive regulation of transcription from RNA polymerase II promoter in response to stress; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of vascular endothelial growth factor production; regulation of DNA-templated transcription; regulation of osteoblast differentiation; regulation of synaptic plasticity; regulation of transcription by RNA polymerase II; response to endoplasmic reticulum stress; response to manganese-induced endoplasmic reticulum stress; response to nutrient levels; response to toxic substance; rhythmic process; transcription by RNA polymerase II","cAMP response element binding protein binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; general transcription initiation factor binding; identical protein binding; leucine zipper domain binding; promoter-specific chromatin binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","ATF1-ATF4 transcription factor complex; ATF4-CREB1 transcription factor complex; centrosome; CHOP-ATF4 complex; chromatin; cytoplasm; cytoskeleton; dendrite membrane; Lewy body core; membrane; microtubule organizing center; neuron projection; nuclear periphery; nuclear speck; nucleoplasm; nucleus; plasma membrane; protein-containing complex; RNA polymerase II transcription regulator complex; transcription regulator complex",null,"activating transcription factor 4","http://www.ncbi.nlm.nih.gov/gene/?term=468","468","11911","79255","474503",null,null,"P18848","Q06507","Q9ES19","A0A8I3PFQ3","A0A287BLS7",null,"GO:1990590; GO:1990589; GO:0005813; GO:1990617; GO:0000785; GO:0005737; GO:0005856; GO:0032590; GO:1990037; GO:0016020; GO:0005815; GO:0043005; GO:0034399; GO:0016607; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0090575; GO:0005667","GO:0008140; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0140296; GO:0042802; GO:0043522; GO:1990841; GO:0005515; GO:0008022; GO:0046982; GO:0019901; GO:0000978; GO:0000977; GO:0061629; GO:0043565; GO:1990837; GO:0000976","GO:0030282; GO:0006874; GO:0034198; GO:1903351; GO:0042149; GO:1990253; GO:0034599; GO:0090650; GO:0034644; GO:0032922; GO:0007623; GO:0035162; GO:0030968; GO:0007214; GO:0006094; GO:0140468; GO:0140467; GO:0070059; GO:0070982; GO:0070309; GO:0042789; GO:0120163; GO:1903204; GO:0043267; GO:0000122; GO:0032057; GO:0030182; GO:0036499; GO:0043065; GO:0070169; GO:0045893; GO:0010628; GO:0043525; GO:2000120; GO:0045943; GO:0045944; GO:0061395; GO:1990440; GO:0036091; GO:0036003; GO:1905461; GO:0010575; GO:0006355; GO:0045667; GO:0048167; GO:0006357; GO:0034976; GO:1990737; GO:0031667; GO:0009636; GO:0048511; GO:0006366","PTHR13044:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=786|UniProtKB=P18848","P00006"]
["ATF6 alpha",null,"ATF6","74","rb",null,2,2,2,7,7,7,"# 0726",".ALZ., .APH., .APO., .CD., .CSP., .DI., .OP., .OPA., .OT., .ST., .TRASR.","Apoptosis signaling pathway","CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 ALPHA","ATF6-mediated unfolded protein response; endoplasmic reticulum unfolded protein response; ERAD pathway; eye development; positive regulation of apoptotic process; positive regulation of ATF6-mediated unfolded protein response; positive regulation of autophagy; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; protein folding; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to unfolded protein; signal transduction; visual perception","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; membrane; nuclear envelope; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Transcription regulation","activating transcription factor 6","http://www.ncbi.nlm.nih.gov/gene/?term=22926","22926","226641",null,"488660",null,null,"P18850","F6VAN0","A0A8I5ZTX7","A0A8P0P781","A0A287A574","A0A5F7ZD43","GO:0000785; GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0005794; GO:0000139; GO:0016020; GO:0005635; GO:0005654; GO:0005634; GO:0090575","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0046982; GO:0000978; GO:0000977; GO:0043565; GO:1990837; GO:0000976; GO:0031625","GO:0036500; GO:0030968; GO:0036503; GO:0001654; GO:0043065; GO:1903893; GO:0010508; GO:0045944; GO:1990440; GO:0006457; GO:0006355; GO:0006357; GO:0006986; GO:0007165; GO:0007601","PTHR46164:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=791|UniProtKB=P18850","P00006"]
["ATG5 (APG5L)",null,"ATG5","32","ms",null,6,2,2,8,6,2,"# 0612",".APH., .APO., .CD., .CSP., .DRR., .IIR., .IMU., .IMUF., .IMUR., .OP., .OT., .OXS., .SREME., .TCR., .TRASR., .UBI., .VIR.",null,"AUTOPHAGY PROTEIN 5","aggrephagy; antigen processing and presentation of endogenous antigen; apoptotic process; autophagosome assembly; autophagy; autophagy of mitochondrion; autophagy of nucleus; blood vessel remodeling; cardiac muscle cell apoptotic process; cellular response to nitrogen starvation; cellular response to nitrosative stress; cellular response to starvation; chaperone-mediated autophagy; C-terminal protein lipidation; establishment of localization in cell; heart contraction; immune system process; macroautophagy; mucus secretion; negative regulation of apoptotic process; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell death; negative regulation of defense response to virus; negative regulation of histone H4-K16 acetylation; negative regulation of innate immune response; negative regulation of phagocytosis; negative regulation of protein ubiquitination; negative regulation of reactive oxygen species metabolic process; negative regulation of type I interferon production; negative stranded viral RNA replication; negative thymic T cell selection; otolith development; positive regulation of mucus secretion; positive regulation of viral translation; post-translational protein modification; protein lipidation; protein lipidation involved in autophagosome assembly; protein ubiquitination; regulation of autophagosome maturation; regulation of cilium assembly; regulation of cytokine production involved in immune response; regulation of reactive oxygen species metabolic process; regulation of release of sequestered calcium ion into cytosol; response to fluoride; response to fungus; response to iron(II) ion; response to xenobiotic stimulus; vasodilation; ventricular cardiac muscle cell development","protein binding","Atg12-Atg5-Atg16 complex; autophagosome; axon; axoneme; cytoplasm; cytosol; membrane; mitochondria-associated endoplasmic reticulum membrane; phagocytic vesicle membrane; phagophore assembly site membrane; protein-containing complex; transferase complex",null,"autophagy related 5","http://www.ncbi.nlm.nih.gov/gene/?term=9474","9474","11793",null,null,null,"696874","Q9H1Y0","Q99J83","Q3MQ06","A0A8I3N429","A0A287B187","A0A5F7ZYF8","GO:0034274; GO:0005776; GO:0030424; GO:0005930; GO:0005737; GO:0005829; GO:0016020; GO:0044233; GO:0030670; GO:0034045; GO:0032991; GO:1990234","GO:0005515","GO:0035973; GO:0019883; GO:0006915; GO:0000045; GO:0006914; GO:0000422; GO:0044804; GO:0001974; GO:0010659; GO:0006995; GO:0071500; GO:0009267; GO:0061684; GO:0006501; GO:0051649; GO:0060047; GO:0002376; GO:0016236; GO:0070254; GO:0043066; GO:0010667; GO:0060548; GO:0050687; GO:2000619; GO:0045824; GO:0050765; GO:0031397; GO:2000378; GO:0032480; GO:0039689; GO:0045060; GO:0048840; GO:0070257; GO:1904973; GO:0043687; GO:0006497; GO:0061739; GO:0016567; GO:1901096; GO:1902017; GO:0002718; GO:2000377; GO:0051279; GO:1902617; GO:0009620; GO:0010040; GO:0009410; GO:0042311; GO:0055015","PTHR13040:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=589|UniProtKB=Q9H1Y0"]
["ATG5 (APG5L)",null,"ATG5","55","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2836",".APH., .APO., .CD., .CSP., .DRR., .IIR., .IMU., .IMUF., .IMUR., .OP., .OT., .OXS., .SREME., .TCR., .TRASR., .UBI., .VIR.",null,"AUTOPHAGY PROTEIN 5","aggrephagy; antigen processing and presentation of endogenous antigen; apoptotic process; autophagosome assembly; autophagy; autophagy of mitochondrion; autophagy of nucleus; blood vessel remodeling; cardiac muscle cell apoptotic process; cellular response to nitrogen starvation; cellular response to nitrosative stress; cellular response to starvation; chaperone-mediated autophagy; C-terminal protein lipidation; establishment of localization in cell; heart contraction; immune system process; macroautophagy; mucus secretion; negative regulation of apoptotic process; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell death; negative regulation of defense response to virus; negative regulation of histone H4-K16 acetylation; negative regulation of innate immune response; negative regulation of phagocytosis; negative regulation of protein ubiquitination; negative regulation of reactive oxygen species metabolic process; negative regulation of type I interferon production; negative stranded viral RNA replication; negative thymic T cell selection; otolith development; positive regulation of mucus secretion; positive regulation of viral translation; post-translational protein modification; protein lipidation; protein lipidation involved in autophagosome assembly; protein ubiquitination; regulation of autophagosome maturation; regulation of cilium assembly; regulation of cytokine production involved in immune response; regulation of reactive oxygen species metabolic process; regulation of release of sequestered calcium ion into cytosol; response to fluoride; response to fungus; response to iron(II) ion; response to xenobiotic stimulus; vasodilation; ventricular cardiac muscle cell development","protein binding","Atg12-Atg5-Atg16 complex; autophagosome; axon; axoneme; cytoplasm; cytosol; membrane; mitochondria-associated endoplasmic reticulum membrane; phagocytic vesicle membrane; phagophore assembly site membrane; protein-containing complex; transferase complex",null,"autophagy related 5","http://www.ncbi.nlm.nih.gov/gene/?term=9474","9474","11793",null,null,null,"696874","Q9H1Y0","Q99J83","Q3MQ06","A0A8I3N429","A0A287B187","A0A5F7ZYF8","GO:0034274; GO:0005776; GO:0030424; GO:0005930; GO:0005737; GO:0005829; GO:0016020; GO:0044233; GO:0030670; GO:0034045; GO:0032991; GO:1990234","GO:0005515","GO:0035973; GO:0019883; GO:0006915; GO:0000045; GO:0006914; GO:0000422; GO:0044804; GO:0001974; GO:0010659; GO:0006995; GO:0071500; GO:0009267; GO:0061684; GO:0006501; GO:0051649; GO:0060047; GO:0002376; GO:0016236; GO:0070254; GO:0043066; GO:0010667; GO:0060548; GO:0050687; GO:2000619; GO:0045824; GO:0050765; GO:0031397; GO:2000378; GO:0032480; GO:0039689; GO:0045060; GO:0048840; GO:0070257; GO:1904973; GO:0043687; GO:0006497; GO:0061739; GO:0016567; GO:1901096; GO:1902017; GO:0002718; GO:2000377; GO:0051279; GO:1902617; GO:0009620; GO:0010040; GO:0009410; GO:0042311; GO:0055015","PTHR13040:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=589|UniProtKB=Q9H1Y0"]
["ATM",null,"ATM","350","rb",null,1,4,4,4,4,4,"# 1080",".APH., .APO., .BCR., .CCP., .CCY., .CD., .CSP., .DDR., .DREP., .FOXO., .HIF., .IMU., .IMUF., .IMUR., .MIG., .MTOR., .NFKB., .OP., .OPA., .OT., .P53S., .RTK., .SREME., .ST., .TD., .TMAT., .TRASR.","p53 pathway; p53 pathway feedback loops 2","SERINE-PROTEIN KINASE ATM","apoptotic process; brain development; cell cycle; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to nitrosative stress; cellular response to retinoic acid; cellular response to X-ray; cellular senescence; chromosome organization involved in meiotic cell cycle; determination of adult lifespan; DNA damage checkpoint signaling; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; establishment of protein-containing complex localization to telomere; establishment of RNA localization to telomere; female gamete generation; female gonad development; female meiotic nuclear division; heart development; histone mRNA catabolic process; immune system process; intrinsic apoptotic signaling pathway in response to DNA damage; lipoprotein catabolic process; male meiotic nuclear division; meiotic telomere clustering; mitotic G2 DNA damage checkpoint signaling; mitotic spindle assembly checkpoint signaling; multicellular organism growth; negative regulation of B cell proliferation; negative regulation of telomere capping; negative regulation of TORC1 signaling; neuron apoptotic process; oocyte development; ovarian follicle development; peptidyl-serine autophosphorylation; peptidyl-serine phosphorylation; pexophagy; phosphatidylinositol-3-phosphate biosynthetic process; phosphorylation; positive regulation of apoptotic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of DNA catabolic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of neuron death; positive regulation of response to DNA damage stimulus; positive regulation of response to stimulus; positive regulation of telomerase catalytic core complex assembly; positive regulation of telomere maintenance via telomerase; positive regulation of telomere maintenance via telomere lengthening; positive regulation of transcription by RNA polymerase II; post-embryonic development; pre-B cell allelic exclusion; protein autophosphorylation; protein phosphorylation; reciprocal meiotic recombination; regulation of apoptotic process; regulation of autophagy; regulation of cell cycle; regulation of cellular response to gamma radiation; regulation of cellular response to heat; regulation of cellular response to stress; regulation of microglial cell activation; regulation of nucleobase-containing compound metabolic process; regulation of signal transduction by p53 class mediator; regulation of telomerase activity; regulation of telomere maintenance via telomerase; replicative senescence; response to hypoxia; response to ionizing radiation; response to stress; signal transduction; signal transduction in response to DNA damage; somitogenesis; telomere maintenance; thymus development; V(D)J recombination","1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA-dependent protein kinase activity; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transferase activity","centrosome; chromosome, telomeric region; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; DNA repair complex; intracellular membrane-bounded organelle; microtubule organizing center; nucleolus; nucleoplasm; nucleus; peroxisomal matrix; peroxisome; spindle","DNA damage","ATM serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=472","472","11920","300711",null,null,null,"Q13315","Q62388","D4ACL8","A0A8P0SR22","A0A287ADU3","A0A5F7ZIZ4","GO:0005813; GO:0000781; GO:0005737; GO:0031410; GO:0005856; GO:0005829; GO:1990391; GO:0043231; GO:0005815; GO:0005730; GO:0005654; GO:0005634; GO:0005782; GO:0005777; GO:0005819","GO:0016303; GO:0005524; GO:0003677; GO:0004677; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0047485; GO:0106310; GO:0004674; GO:0044877; GO:0016740","GO:0006915; GO:0007420; GO:0007049; GO:0006974; GO:0071480; GO:0071500; GO:0071300; GO:0071481; GO:0090398; GO:0070192; GO:0008340; GO:0000077; GO:0006977; GO:0006281; GO:0006302; GO:0000724; GO:0006303; GO:0097695; GO:0097694; GO:0007292; GO:0008585; GO:0007143; GO:0007507; GO:0071044; GO:0002376; GO:0008630; GO:0042159; GO:0007140; GO:0045141; GO:0007095; GO:0007094; GO:0035264; GO:0030889; GO:1904354; GO:1904262; GO:0051402; GO:0048599; GO:0001541; GO:0036289; GO:0018105; GO:0000425; GO:0036092; GO:0016310; GO:0043065; GO:0045785; GO:0030335; GO:1903626; GO:0043517; GO:0010628; GO:0043525; GO:1901216; GO:2001022; GO:0048584; GO:1904884; GO:0032212; GO:1904358; GO:0045944; GO:0009791; GO:0002331; GO:0046777; GO:0006468; GO:0007131; GO:0042981; GO:0010506; GO:0051726; GO:1905843; GO:1900034; GO:0080135; GO:1903978; GO:0019219; GO:1901796; GO:0051972; GO:0032210; GO:0090399; GO:0001666; GO:0010212; GO:0006950; GO:0007165; GO:0042770; GO:0001756; GO:0000723; GO:0048538; GO:0033151","PTHR11139:SF72","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=795|UniProtKB=Q13315","P00059; P04398"]
["ATM - phospho","Ser1981","ATM","350","rb",null,7,2.1,"n/a","n/a","n/a","n/a","# 1370",".APH., .APO., .BCR., .CCP., .CCY., .CD., .CSP., .DDR., .DREP., .FOXO., .HIF., .IMU., .IMUF., .IMUR., .MIG., .MTOR., .NFKB., .OP., .OPA., .OT., .P53S., .RTK., .SREME., .ST., .TD., .TMAT., .TRASR.","p53 pathway; p53 pathway feedback loops 2","SERINE-PROTEIN KINASE ATM","apoptotic process; brain development; cell cycle; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to nitrosative stress; cellular response to retinoic acid; cellular response to X-ray; cellular senescence; chromosome organization involved in meiotic cell cycle; determination of adult lifespan; DNA damage checkpoint signaling; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; establishment of protein-containing complex localization to telomere; establishment of RNA localization to telomere; female gamete generation; female gonad development; female meiotic nuclear division; heart development; histone mRNA catabolic process; immune system process; intrinsic apoptotic signaling pathway in response to DNA damage; lipoprotein catabolic process; male meiotic nuclear division; meiotic telomere clustering; mitotic G2 DNA damage checkpoint signaling; mitotic spindle assembly checkpoint signaling; multicellular organism growth; negative regulation of B cell proliferation; negative regulation of telomere capping; negative regulation of TORC1 signaling; neuron apoptotic process; oocyte development; ovarian follicle development; peptidyl-serine autophosphorylation; peptidyl-serine phosphorylation; pexophagy; phosphatidylinositol-3-phosphate biosynthetic process; phosphorylation; positive regulation of apoptotic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of DNA catabolic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of neuron death; positive regulation of response to DNA damage stimulus; positive regulation of response to stimulus; positive regulation of telomerase catalytic core complex assembly; positive regulation of telomere maintenance via telomerase; positive regulation of telomere maintenance via telomere lengthening; positive regulation of transcription by RNA polymerase II; post-embryonic development; pre-B cell allelic exclusion; protein autophosphorylation; protein phosphorylation; reciprocal meiotic recombination; regulation of apoptotic process; regulation of autophagy; regulation of cell cycle; regulation of cellular response to gamma radiation; regulation of cellular response to heat; regulation of cellular response to stress; regulation of microglial cell activation; regulation of nucleobase-containing compound metabolic process; regulation of signal transduction by p53 class mediator; regulation of telomerase activity; regulation of telomere maintenance via telomerase; replicative senescence; response to hypoxia; response to ionizing radiation; response to stress; signal transduction; signal transduction in response to DNA damage; somitogenesis; telomere maintenance; thymus development; V(D)J recombination","1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA-dependent protein kinase activity; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transferase activity","centrosome; chromosome, telomeric region; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; DNA repair complex; intracellular membrane-bounded organelle; microtubule organizing center; nucleolus; nucleoplasm; nucleus; peroxisomal matrix; peroxisome; spindle","DNA damage","ATM serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=472","472","11920","300711",null,null,null,"Q13315","Q62388","D4ACL8","A0A8P0SR22","A0A287ADU3","A0A5F7ZIZ4","GO:0005813; GO:0000781; GO:0005737; GO:0031410; GO:0005856; GO:0005829; GO:1990391; GO:0043231; GO:0005815; GO:0005730; GO:0005654; GO:0005634; GO:0005782; GO:0005777; GO:0005819","GO:0016303; GO:0005524; GO:0003677; GO:0004677; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0047485; GO:0106310; GO:0004674; GO:0044877; GO:0016740","GO:0006915; GO:0007420; GO:0007049; GO:0006974; GO:0071480; GO:0071500; GO:0071300; GO:0071481; GO:0090398; GO:0070192; GO:0008340; GO:0000077; GO:0006977; GO:0006281; GO:0006302; GO:0000724; GO:0006303; GO:0097695; GO:0097694; GO:0007292; GO:0008585; GO:0007143; GO:0007507; GO:0071044; GO:0002376; GO:0008630; GO:0042159; GO:0007140; GO:0045141; GO:0007095; GO:0007094; GO:0035264; GO:0030889; GO:1904354; GO:1904262; GO:0051402; GO:0048599; GO:0001541; GO:0036289; GO:0018105; GO:0000425; GO:0036092; GO:0016310; GO:0043065; GO:0045785; GO:0030335; GO:1903626; GO:0043517; GO:0010628; GO:0043525; GO:1901216; GO:2001022; GO:0048584; GO:1904884; GO:0032212; GO:1904358; GO:0045944; GO:0009791; GO:0002331; GO:0046777; GO:0006468; GO:0007131; GO:0042981; GO:0010506; GO:0051726; GO:1905843; GO:1900034; GO:0080135; GO:1903978; GO:0019219; GO:1901796; GO:0051972; GO:0032210; GO:0090399; GO:0001666; GO:0010212; GO:0006950; GO:0007165; GO:0042770; GO:0001756; GO:0000723; GO:0048538; GO:0033151","PTHR11139:SF72","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=795|UniProtKB=Q13315","P00059; P04398"]
["ATP citrate lyase",null,"ACLY","122","rb",null,2,2,6,6,2,2,"# 1133",null,"Pyruvate metabolism","ATP-CITRATE SYNTHASE","acetyl-CoA biosynthetic process; cholesterol biosynthetic process; citrate metabolic process; coenzyme A metabolic process; fatty acid biosynthetic process; lipid biosynthetic process; lipid metabolic process; oxaloacetate metabolic process; tricarboxylic acid cycle","acyltransferase activity, acyl groups converted into alkyl on transfer; ATP binding; ATP citrate synthase activity; catalytic activity; metal ion binding; nucleotide binding; protein binding; transferase activity","azurophil granule lumen; cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; membrane; nucleoplasm",null,"ATP citrate lyase","http://www.ncbi.nlm.nih.gov/gene/?term=47","47","104112",null,null,null,null,"P53396","Q91V92","A0A0G2K5E7","A0A8I3N7J1","F1S0N2","A0A1D5QSI7","GO:0035578; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1904813; GO:0016020; GO:0005654","GO:0046912; GO:0005524; GO:0003878; GO:0003824; GO:0046872; GO:0000166; GO:0005515; GO:0016740","GO:0006085; GO:0006695; GO:0006101; GO:0015936; GO:0006633; GO:0008610; GO:0006629; GO:0006107; GO:0006099","PTHR23118:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=115|UniProtKB=P53396","P02772"]
["ATP7b",null,"ATP7B","157","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1398",null,null,"COPPER-TRANSPORTING ATPASE 2","cation transport; cellular copper ion homeostasis; cellular zinc ion homeostasis; copper ion export; copper ion homeostasis; copper ion import; copper ion transmembrane transport; copper ion transport; establishment of localization in cell; ion transmembrane transport; ion transport; lactation; protein maturation by copper ion transfer; regulation of biological quality; response to copper ion; sequestering of calcium ion; xenobiotic detoxification by transmembrane export across the plasma membrane","ATP binding; ATP hydrolysis activity; ATPase-coupled cation transmembrane transporter activity; copper ion binding; copper ion transmembrane transporter activity; metal ion binding; nucleotide binding; protein binding; P-type divalent copper transporter activity; P-type monovalent copper transporter activity","basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; endosome; Golgi apparatus; Golgi membrane; late endosome; membrane; mitochondrion; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network; trans-Golgi network membrane","Copper transport","ATPase copper transporting beta","http://www.ncbi.nlm.nih.gov/gene/?term=540","540","11979","24218",null,null,null,"P35670","Q64446","A0A0G2JWJ5","A0A8P0S9W2",null,"A0A1D5R7Q5","GO:0016323; GO:0005737; GO:0031410; GO:0005768; GO:0005794; GO:0000139; GO:0005770; GO:0016020; GO:0005739; GO:0048471; GO:0005886; GO:0005802; GO:0032588","GO:0005524; GO:0016887; GO:0019829; GO:0005507; GO:0005375; GO:0046872; GO:0000166; GO:0005515; GO:0043682; GO:0140581","GO:0006812; GO:0006878; GO:0006882; GO:0060003; GO:0055070; GO:0015677; GO:0035434; GO:0006825; GO:0051649; GO:0034220; GO:0006811; GO:0007595; GO:0015680; GO:0065008; GO:0046688; GO:0051208; GO:1990961","PTHR43520:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=870|UniProtKB=P35670"]
["ATPase/GAPDH/Histone H3 (Membran Fraction)",null,"ATP1A1, GAPDH, H3-4","112, 37, 17","ms",null,1,1,"n/a","n/a","n/a","n/a","# 1975",".ALZ., .APH., .APO., .cAMP., .CCP., .CCY., .CD., .CSP., .DI., .DRR., .GPCR., .HIF., .HUNT., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OT., .SREME., .TRASR.","Huntington disease; Glycolysis; DNA replication","SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; HISTONE H3.1T","cardiac muscle cell action potential involved in contraction; cell communication by electrical coupling involved in cardiac conduction; cellular potassium ion homeostasis; cellular response to steroid hormone stimulus; cellular sodium ion homeostasis; establishment or maintenance of transmembrane electrochemical gradient; heart contraction; ion transmembrane transport; ion transport; membrane repolarization; membrane repolarization during cardiac muscle cell action potential; negative regulation of glucocorticoid biosynthetic process; negative regulation of heart contraction; positive regulation of heart contraction; positive regulation of striated muscle contraction; potassium ion import across plasma membrane; potassium ion transport; proton transmembrane transport; regulation of blood pressure; regulation of sodium ion transport; regulation of the force of heart contraction; relaxation of cardiac muscle; response to glycoside; response to xenobiotic stimulus; sodium ion export across plasma membrane; sodium ion transport; antimicrobial humoral immune response mediated by antimicrobial peptide; apoptotic process; cellular response to type II interferon; defense response to fungus; glucose metabolic process; glycolytic process; immune system process; innate immune response; killing by host of symbiont cells; killing of cells of another organism; microtubule cytoskeleton organization; negative regulation of endopeptidase activity; negative regulation of translation; neuron apoptotic process; peptidyl-cysteine S-trans-nitrosylation; positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of type I interferon production; protein stabilization; regulation of macroautophagy; regulation of translation; nucleosome assembly","ATP binding; ATP hydrolysis activity; ATPase-coupled cation transmembrane transporter activity; chaperone binding; metal ion binding; nucleotide binding; phosphatase activity; potassium ion binding; protein binding; protein heterodimerization activity; P-type potassium transmembrane transporter activity; P-type sodium:potassium-exchanging transporter activity; sodium ion binding; steroid hormone binding; aspartic-type endopeptidase inhibitor activity; disordered domain specific binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; identical protein binding; microtubule binding; NAD binding; NADP binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; peptidyl-cysteine S-nitrosylase activity; transferase activity; DNA binding; structural constituent of chromatin","apical plasma membrane; axon; basolateral plasma membrane; cell projection; endoplasmic reticulum; extracellular exosome; extracellular vesicle; Golgi apparatus; lateral plasma membrane; melanosome; membrane; membrane raft; organelle membrane; photoreceptor inner segment membrane; plasma membrane; postsynaptic density; protein-containing complex; sarcolemma; sodium:potassium-exchanging ATPase complex; sperm flagellum; T-tubule; cytoplasm; cytoskeleton; cytosol; GAIT complex; intracellular membrane-bounded organelle; lipid droplet; microtubule cytoskeleton; nuclear membrane; nucleus; perinuclear region of cytoplasm; ribonucleoprotein complex; vesicle; chromatin; chromosome; chromosome, telomeric region; nucleoplasm; nucleosome",null,"ATPase Na+/K+ transporting subunit alpha 1; glyceraldehyde-3-phosphate dehydrogenase; H3.4 histone, cluster member","http://www.ncbi.nlm.nih.gov/gene/?term=476, http://www.ncbi.nlm.nih.gov/gene/?term=2597, http://www.ncbi.nlm.nih.gov/gene/?term=8290","476, 2597, 8290","11928, 14433","24211","","","NA, 574353","P05023, P04406, Q16695","Q8VDN2, P16858","P06685","A0A8I3Q559","A0A287A4M8","A0A1D5QUS6, I2CWU4","GO:0016324; GO:0030424; GO:0016323; GO:0042995; GO:0005783; GO:0070062; GO:1903561; GO:0005794; GO:0016328; GO:0042470; GO:0016020; GO:0045121; GO:0031090; GO:0060342; GO:0005886; GO:0014069; GO:0032991; GO:0042383; GO:0005890; GO:0036126; GO:0030315; GO:0005737; GO:0005856; GO:0005829; GO:0097452; GO:0043231; GO:0005811; GO:0015630; GO:0031965; GO:0005634; GO:0048471; GO:1990904; GO:0031982; GO:0000785; GO:0005694; GO:0000781; GO:0005654; GO:0000786","GO:0005524; GO:0016887; GO:0019829; GO:0051087; GO:0046872; GO:0000166; GO:0016791; GO:0030955; GO:0005515; GO:0046982; GO:0008556; GO:0005391; GO:0031402; GO:1990239; GO:0019828; GO:0097718; GO:0004365; GO:0042802; GO:0008017; GO:0051287; GO:0050661; GO:0016491; GO:0016620; GO:0035605; GO:0016740; GO:0003677; GO:0030527","GO:0086002; GO:0086064; GO:0030007; GO:0071383; GO:0006883; GO:0010248; GO:0060047; GO:0034220; GO:0006811; GO:0086009; GO:0086013; GO:0031947; GO:0045822; GO:0045823; GO:0045989; GO:1990573; GO:0006813; GO:1902600; GO:0008217; GO:0002028; GO:0002026; GO:0055119; GO:1903416; GO:0009410; GO:0036376; GO:0006814; GO:0061844; GO:0006915; GO:0071346; GO:0050832; GO:0006006; GO:0006096; GO:0002376; GO:0045087; GO:0051873; GO:0031640; GO:0000226; GO:0010951; GO:0017148; GO:0051402; GO:0035606; GO:0001819; GO:0043123; GO:0032481; GO:0050821; GO:0016241; GO:0006417; GO:0006334","PTHR43294:SF9; PTHR10836:SF111; PTHR11426:SF257","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=799|UniProtKB=P05023; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4141|UniProtKB=P04406; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4778|UniProtKB=Q16695","P00029; P00024; P00017"]
["ATR",null,"ATR","250","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1081",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .DRR., .OP., .OPA., .OT., .P53S., .ST.","p53 pathway; p53 pathway feedback loops 2","SERINE/THREONINE-PROTEIN KINASE ATR","cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to UV; DNA damage checkpoint signaling; DNA repair; DNA replication; establishment of protein-containing complex localization to telomere; establishment of RNA localization to telomere; interstrand cross-link repair; negative regulation of DNA replication; nucleobase-containing compound metabolic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of response to stimulus; positive regulation of telomerase catalytic core complex assembly; positive regulation of telomere maintenance via telomerase; protein autophosphorylation; protein localization to chromosome, telomeric region; protein phosphorylation; regulation of cellular component organization; regulation of cellular response to heat; regulation of cellular response to stress; regulation of double-strand break repair; regulation of nucleobase-containing compound metabolic process; replication fork processing; replicative senescence; response to arsenic-containing substance; response to stress; response to xenobiotic stimulus; telomere maintenance","ATP binding; DNA binding; kinase activity; MutLalpha complex binding; MutSalpha complex binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","ATR-ATRIP complex; chromosome; chromosome, telomeric region; Golgi apparatus; nucleoplasm; nucleus; PML body","DNA damage","ATR serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=545","545","245000","685055",null,null,null,"Q13535","A0A1L1SSL9","A0A8I6G5M3","A0A8I3PYV4","A0A8W4F8F5","A0A5F7ZC34","GO:0070310; GO:0005694; GO:0000781; GO:0005794; GO:0005654; GO:0005634; GO:0016605","GO:0005524; GO:0003677; GO:0016301; GO:0032405; GO:0032407; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0006974; GO:0071480; GO:0034644; GO:0000077; GO:0006281; GO:0006260; GO:0097695; GO:0097694; GO:0036297; GO:0008156; GO:0006139; GO:0018105; GO:0016310; GO:0043517; GO:0048584; GO:1904884; GO:0032212; GO:0046777; GO:0070198; GO:0006468; GO:0051128; GO:1900034; GO:0080135; GO:2000779; GO:0019219; GO:0031297; GO:0090399; GO:0046685; GO:0006950; GO:0009410; GO:0000723","PTHR11139:SF69","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=882|UniProtKB=Q13535","P00059; P04398"]
["ATR - phospho","Ser428","ATR","300","rb",null,2,7,7,7,7,7,"# 1892",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .DRR., .OP., .OPA., .OT., .P53S., .ST.","p53 pathway; p53 pathway feedback loops 2","SERINE/THREONINE-PROTEIN KINASE ATR","cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to UV; DNA damage checkpoint signaling; DNA repair; DNA replication; establishment of protein-containing complex localization to telomere; establishment of RNA localization to telomere; interstrand cross-link repair; negative regulation of DNA replication; nucleobase-containing compound metabolic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of response to stimulus; positive regulation of telomerase catalytic core complex assembly; positive regulation of telomere maintenance via telomerase; protein autophosphorylation; protein localization to chromosome, telomeric region; protein phosphorylation; regulation of cellular component organization; regulation of cellular response to heat; regulation of cellular response to stress; regulation of double-strand break repair; regulation of nucleobase-containing compound metabolic process; replication fork processing; replicative senescence; response to arsenic-containing substance; response to stress; response to xenobiotic stimulus; telomere maintenance","ATP binding; DNA binding; kinase activity; MutLalpha complex binding; MutSalpha complex binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","ATR-ATRIP complex; chromosome; chromosome, telomeric region; Golgi apparatus; nucleoplasm; nucleus; PML body","DNA damage","ATR serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=545","545","245000","685055",null,null,null,"Q13535","A0A1L1SSL9","A0A8I6G5M3","A0A8I3PYV4","A0A8W4F8F5","A0A5F7ZC34","GO:0070310; GO:0005694; GO:0000781; GO:0005794; GO:0005654; GO:0005634; GO:0016605","GO:0005524; GO:0003677; GO:0016301; GO:0032405; GO:0032407; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0006974; GO:0071480; GO:0034644; GO:0000077; GO:0006281; GO:0006260; GO:0097695; GO:0097694; GO:0036297; GO:0008156; GO:0006139; GO:0018105; GO:0016310; GO:0043517; GO:0048584; GO:1904884; GO:0032212; GO:0046777; GO:0070198; GO:0006468; GO:0051128; GO:1900034; GO:0080135; GO:2000779; GO:0019219; GO:0031297; GO:0090399; GO:0046685; GO:0006950; GO:0009410; GO:0000723","PTHR11139:SF69","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=882|UniProtKB=Q13535","P00059; P04398"]
["Aurora A (AIK)",null,"AURKA","48","rb",null,1,4,4,4,4,4,"# 0700",".APO., .CCP., .CCY., .CD., .CP., .CSP., .OP., .OPA., .OT., .P53S., .ST., .TRASR.",null,"AURORA KINASE A","anterior/posterior axis specification; apoptotic process; cell cycle; cell division; cell projection organization; centrosome cycle; centrosome localization; cilium disassembly; G2/M transition of mitotic cell cycle; histone modification; liver regeneration; meiotic cell cycle; meiotic spindle organization; microtubule cytoskeleton organization; mitotic cell cycle; mitotic centrosome separation; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of protein binding; neuron projection extension; peptidyl-serine phosphorylation; phosphorylation; positive regulation of mitochondrial fission; positive regulation of mitotic cell cycle; positive regulation of mitotic nuclear division; positive regulation of oocyte maturation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein localization to centrosome; protein phosphorylation; regulation of centrosome cycle; regulation of cytokinesis; regulation of G2/M transition of mitotic cell cycle; regulation of protein stability; regulation of signal transduction by p53 class mediator; response to wounding; spindle assembly involved in female meiosis I; spindle organization","ATP binding; histone serine kinase activity; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding","axon hillock; basolateral plasma membrane; cell projection; centriole; centrosome; chromosome passenger complex; ciliary basal body; cilium; cytoplasm; cytoskeleton; cytosol; germinal vesicle; glutamatergic synapse; meiotic spindle; membrane; microtubule; microtubule cytoskeleton; microtubule organizing center; midbody; mitotic spindle; mitotic spindle pole; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; pronucleus; spindle; spindle microtubule; spindle midzone; spindle pole; spindle pole centrosome","Cell cycle control","aurora kinase A","http://www.ncbi.nlm.nih.gov/gene/?term=6790","6790","20878",null,null,null,"698190","O14965","P97477","A0A8I5ZXM5","A0A8I3S724",null,"F7GNU0","GO:0043203; GO:0016323; GO:0042995; GO:0005814; GO:0005813; GO:0032133; GO:0036064; GO:0005929; GO:0005737; GO:0005856; GO:0005829; GO:0042585; GO:0098978; GO:0072687; GO:0016020; GO:0005874; GO:0015630; GO:0005815; GO:0030496; GO:0072686; GO:0097431; GO:0043005; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0014069; GO:0045120; GO:0005819; GO:0005876; GO:0051233; GO:0000922; GO:0031616","GO:0005524; GO:0035174; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0046982; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0004712; GO:0016740; GO:0031625","GO:0009948; GO:0006915; GO:0007049; GO:0051301; GO:0030030; GO:0007098; GO:0051642; GO:0061523; GO:0000086; GO:0016570; GO:0097421; GO:0051321; GO:0000212; GO:0000226; GO:0000278; GO:0007100; GO:0007052; GO:0043066; GO:0010629; GO:0032091; GO:1990138; GO:0018105; GO:0016310; GO:0090141; GO:0045931; GO:0045840; GO:1900195; GO:0032436; GO:0043161; GO:0046777; GO:0071539; GO:0006468; GO:0046605; GO:0032465; GO:0010389; GO:0031647; GO:1901796; GO:0009611; GO:0007057; GO:0007051","PTHR24350:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11393|UniProtKB=O14965"]
["Aurora A (AIK) - phospho","Thr288","AURKA","48","rb",null,1,4,2.1,4,4,4,"# 0683",".APO., .CCP., .CCY., .CD., .CP., .CSP., .OP., .OPA., .OT., .P53S., .ST., .TRASR.",null,"AURORA KINASE A","anterior/posterior axis specification; apoptotic process; cell cycle; cell division; cell projection organization; centrosome cycle; centrosome localization; cilium disassembly; G2/M transition of mitotic cell cycle; histone modification; liver regeneration; meiotic cell cycle; meiotic spindle organization; microtubule cytoskeleton organization; mitotic cell cycle; mitotic centrosome separation; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of protein binding; neuron projection extension; peptidyl-serine phosphorylation; phosphorylation; positive regulation of mitochondrial fission; positive regulation of mitotic cell cycle; positive regulation of mitotic nuclear division; positive regulation of oocyte maturation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein localization to centrosome; protein phosphorylation; regulation of centrosome cycle; regulation of cytokinesis; regulation of G2/M transition of mitotic cell cycle; regulation of protein stability; regulation of signal transduction by p53 class mediator; response to wounding; spindle assembly involved in female meiosis I; spindle organization","ATP binding; histone serine kinase activity; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding","axon hillock; basolateral plasma membrane; cell projection; centriole; centrosome; chromosome passenger complex; ciliary basal body; cilium; cytoplasm; cytoskeleton; cytosol; germinal vesicle; glutamatergic synapse; meiotic spindle; membrane; microtubule; microtubule cytoskeleton; microtubule organizing center; midbody; mitotic spindle; mitotic spindle pole; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; pronucleus; spindle; spindle microtubule; spindle midzone; spindle pole; spindle pole centrosome","Cell cycle control","aurora kinase A","http://www.ncbi.nlm.nih.gov/gene/?term=6790","6790","20878",null,null,null,"698190","O14965","P97477","A0A8I5ZXM5","A0A8I3S724",null,"F7GNU0","GO:0043203; GO:0016323; GO:0042995; GO:0005814; GO:0005813; GO:0032133; GO:0036064; GO:0005929; GO:0005737; GO:0005856; GO:0005829; GO:0042585; GO:0098978; GO:0072687; GO:0016020; GO:0005874; GO:0015630; GO:0005815; GO:0030496; GO:0072686; GO:0097431; GO:0043005; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0014069; GO:0045120; GO:0005819; GO:0005876; GO:0051233; GO:0000922; GO:0031616","GO:0005524; GO:0035174; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0046982; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0004712; GO:0016740; GO:0031625","GO:0009948; GO:0006915; GO:0007049; GO:0051301; GO:0030030; GO:0007098; GO:0051642; GO:0061523; GO:0000086; GO:0016570; GO:0097421; GO:0051321; GO:0000212; GO:0000226; GO:0000278; GO:0007100; GO:0007052; GO:0043066; GO:0010629; GO:0032091; GO:1990138; GO:0018105; GO:0016310; GO:0090141; GO:0045931; GO:0045840; GO:1900195; GO:0032436; GO:0043161; GO:0046777; GO:0071539; GO:0006468; GO:0046605; GO:0032465; GO:0010389; GO:0031647; GO:1901796; GO:0009611; GO:0007057; GO:0007051","PTHR24350:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11393|UniProtKB=O14965"]
["Aurora A/B/C - phospho","Thr288/Thr232/Thr198","AURKA, AURKB, AURKC","48, 40, 35","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1945",".APO., .CCP., .CCY., .CD., .CP., .CSP., .OP., .OPA., .OT., .P53S., .ST., .TRASR.",null,"AURORA KINASE A; AURORA KINASE B; AURORA KINASE C","anterior/posterior axis specification; apoptotic process; cell cycle; cell division; cell projection organization; centrosome cycle; centrosome localization; cilium disassembly; G2/M transition of mitotic cell cycle; histone modification; liver regeneration; meiotic cell cycle; meiotic spindle organization; microtubule cytoskeleton organization; mitotic cell cycle; mitotic centrosome separation; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of protein binding; neuron projection extension; peptidyl-serine phosphorylation; phosphorylation; positive regulation of mitochondrial fission; positive regulation of mitotic cell cycle; positive regulation of mitotic nuclear division; positive regulation of oocyte maturation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein localization to centrosome; protein phosphorylation; regulation of centrosome cycle; regulation of cytokinesis; regulation of G2/M transition of mitotic cell cycle; regulation of protein stability; regulation of signal transduction by p53 class mediator; response to wounding; spindle assembly involved in female meiosis I; spindle organization; abscission; aging; attachment of spindle microtubules to kinetochore; cell population proliferation; cellular response to UV; cleavage furrow formation; mitotic cytokinesis; mitotic cytokinesis checkpoint signaling; mitotic spindle midzone assembly; negative regulation of B cell apoptotic process; negative regulation of cytokinesis; negative regulation of transcription by RNA polymerase II; positive regulation of attachment of mitotic spindle microtubules to kinetochore; positive regulation of cytokinesis; positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of mitotic cytokinesis; positive regulation of mitotic sister chromatid segregation; positive regulation of mitotic sister chromatid separation; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; post-translational protein modification; protein localization to kinetochore; regulation of chromosome segregation","ATP binding; histone serine kinase activity; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding; kinase binding","axon hillock; basolateral plasma membrane; cell projection; centriole; centrosome; chromosome passenger complex; ciliary basal body; cilium; cytoplasm; cytoskeleton; cytosol; germinal vesicle; glutamatergic synapse; meiotic spindle; membrane; microtubule; microtubule cytoskeleton; microtubule organizing center; midbody; mitotic spindle; mitotic spindle pole; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; pronucleus; spindle; spindle microtubule; spindle midzone; spindle pole; spindle pole centrosome; chromocenter; chromosome; chromosome, centromeric region; condensed chromosome, centromeric region; kinetochore; mitotic spindle midzone; condensed chromosome","Cell cycle control","aurora kinase A; aurora kinase B; aurora kinase C","http://www.ncbi.nlm.nih.gov/gene/?term=6790, http://www.ncbi.nlm.nih.gov/gene/?term=9212, http://www.ncbi.nlm.nih.gov/gene/?term=6795","6790, 9212, 6795","20878, 20877, 20871","NA, 114592","NA, 479492","","698190, 721955","O14965, Q96GD4, Q9UQB9","P97477, O70126, O88445","A0A8I5ZXM5, O55099, A0A8I6G3L3","A0A8I3S724, A0A8I3Q4W5","A0A5G2QDV6","F7GNU0, F6VVA5","GO:0043203; GO:0016323; GO:0042995; GO:0005814; GO:0005813; GO:0032133; GO:0036064; GO:0005929; GO:0005737; GO:0005856; GO:0005829; GO:0042585; GO:0098978; GO:0072687; GO:0016020; GO:0005874; GO:0015630; GO:0005815; GO:0030496; GO:0072686; GO:0097431; GO:0043005; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0014069; GO:0045120; GO:0005819; GO:0005876; GO:0051233; GO:0000922; GO:0031616; GO:0010369; GO:0005694; GO:0000775; GO:0000779; GO:0000776; GO:1990023; GO:0000793","GO:0005524; GO:0035174; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0046982; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0004712; GO:0016740; GO:0031625; GO:0019900","GO:0009948; GO:0006915; GO:0007049; GO:0051301; GO:0030030; GO:0007098; GO:0051642; GO:0061523; GO:0000086; GO:0016570; GO:0097421; GO:0051321; GO:0000212; GO:0000226; GO:0000278; GO:0007100; GO:0007052; GO:0043066; GO:0010629; GO:0032091; GO:1990138; GO:0018105; GO:0016310; GO:0090141; GO:0045931; GO:0045840; GO:1900195; GO:0032436; GO:0043161; GO:0046777; GO:0071539; GO:0006468; GO:0046605; GO:0032465; GO:0010389; GO:0031647; GO:1901796; GO:0009611; GO:0007057; GO:0007051; GO:0009838; GO:0007568; GO:0008608; GO:0008283; GO:0034644; GO:0036089; GO:0000281; GO:0044878; GO:0051256; GO:0002903; GO:0032466; GO:0000122; GO:1902425; GO:0032467; GO:1905116; GO:0090267; GO:1903490; GO:0062033; GO:1901970; GO:0001934; GO:0051973; GO:1904355; GO:0032212; GO:0043687; GO:0034501; GO:0051983","PTHR24350:SF5; PTHR24350:SF4; PTHR24350:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11393|UniProtKB=O14965; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11390|UniProtKB=Q96GD4; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11391|UniProtKB=Q9UQB9"]
["Aurora B (AIM1)",null,"AURKB","40","rb",null,2,6,8,8,8,3,"# 0685",".APO., .CCP., .CCY., .CD., .CP., .CSP., .OP., .OPA., .OT., .P53S., .ST., .TRASR.",null,"AURORA KINASE B","abscission; aging; attachment of spindle microtubules to kinetochore; cell cycle; cell division; cell population proliferation; cellular response to UV; cleavage furrow formation; histone modification; mitotic cell cycle; mitotic cytokinesis; mitotic cytokinesis checkpoint signaling; mitotic spindle midzone assembly; mitotic spindle organization; negative regulation of B cell apoptotic process; negative regulation of cytokinesis; negative regulation of protein binding; negative regulation of transcription by RNA polymerase II; phosphorylation; positive regulation of attachment of mitotic spindle microtubules to kinetochore; positive regulation of cytokinesis; positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of mitotic cytokinesis; positive regulation of mitotic sister chromatid segregation; positive regulation of mitotic sister chromatid separation; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; post-translational protein modification; protein autophosphorylation; protein localization to kinetochore; protein phosphorylation; regulation of chromosome segregation; regulation of cytokinesis; regulation of signal transduction by p53 class mediator; spindle organization","ATP binding; histone serine kinase activity; kinase activity; kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transferase activity","chromocenter; chromosome; chromosome passenger complex; chromosome, centromeric region; condensed chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; kinetochore; microtubule cytoskeleton; midbody; mitotic spindle midzone; mitotic spindle pole; nucleoplasm; nucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome","Cell cycle control","aurora kinase B","http://www.ncbi.nlm.nih.gov/gene/?term=9212","9212","20877","114592","479492",null,"721955","Q96GD4","O70126","O55099","A0A8I3Q4W5","A0A5G2QDV6","F6VVA5","GO:0010369; GO:0005694; GO:0032133; GO:0000775; GO:0000779; GO:0005737; GO:0005856; GO:0005829; GO:0000776; GO:0015630; GO:0030496; GO:1990023; GO:0097431; GO:0005654; GO:0005634; GO:0005819; GO:0005876; GO:0051233; GO:0031616","GO:0005524; GO:0035174; GO:0016301; GO:0019900; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0016740","GO:0009838; GO:0007568; GO:0008608; GO:0007049; GO:0051301; GO:0008283; GO:0034644; GO:0036089; GO:0016570; GO:0000278; GO:0000281; GO:0044878; GO:0051256; GO:0007052; GO:0002903; GO:0032466; GO:0032091; GO:0000122; GO:0016310; GO:1902425; GO:0032467; GO:1905116; GO:0090267; GO:1903490; GO:0062033; GO:1901970; GO:0001934; GO:0051973; GO:1904355; GO:0032212; GO:0043687; GO:0046777; GO:0034501; GO:0006468; GO:0051983; GO:0032465; GO:1901796; GO:0007051","PTHR24350:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11390|UniProtKB=Q96GD4"]
["Aven",null,"AVEN","50","rb",null,1,1,8,8,8,8,"# 0677",".APO., .CCP., .CCY., .CD., .CSP., .OP.",null,"CELL DEATH REGULATOR AVEN","apoptotic process; negative regulation of apoptotic process; negative regulation of G2/M transition of mitotic cell cycle","protein binding","cytosol; endomembrane system; membrane","Apoptosis","apoptosis and caspase activation inhibitor","http://www.ncbi.nlm.nih.gov/gene/?term=57099","57099","74268",null,null,null,"695227","Q9NQS1","Q9D9K3","A0A8I5ZPL1",null,"A0A287ANF5","A0A1D5QCC2","GO:0005829; GO:0012505; GO:0016020","GO:0005515","GO:0006915; GO:0043066; GO:0010972","PTHR16524:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13509|UniProtKB=Q9NQS1"]
["Axin1",null,"AXIN1","110","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1683",".ALZ., .ANG., .APO., .BRC., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .DEV., .DI., .EMC., .HIPPO., .JNK., .MAPK., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TGFB., .TRASR., .UBI., .WNT.","Angiogenesis; Wnt signaling pathway","AXIN-1","activation of protein kinase activity; apoptotic process; axial mesoderm development; axial mesoderm formation; canonical Wnt signaling pathway; cell development; cytoplasmic microtubule organization; dorsal/ventral axis specification; dorsal/ventral pattern formation; genomic imprinting; head development; in utero embryonic development; negative regulation of canonical Wnt signaling pathway; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of protein metabolic process; negative regulation of transcription elongation by RNA polymerase II; negative regulation of Wnt signaling pathway; nucleocytoplasmic transport; positive regulation of DNA-templated transcription; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein transferase activity; post-anal tail morphogenesis; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process; protein polyubiquitination; protein-containing complex assembly; regulation of canonical Wnt signaling pathway; regulation of protein phosphorylation; regulation of Wnt signaling pathway; sensory perception of sound; Wnt signaling pathway","armadillo repeat domain binding; beta-catenin binding; enzyme binding; identical protein binding; I-SMAD binding; molecular adaptor activity; p53 binding; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein self-association; R-SMAD binding; signaling adaptor activity; signaling receptor complex adaptor activity; SMAD binding; ubiquitin protein ligase binding","beta-catenin destruction complex; cell cortex; cell periphery; cytoplasm; cytoplasmic vesicle; cytosol; lateral plasma membrane; membrane; microtubule cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; Wnt signalosome","Wnt signaling","axin 1","http://www.ncbi.nlm.nih.gov/gene/?term=8312","8312","12005",null,null,null,"100424087","O15169","O35625",null,"A0A8I3Q4M1","A0A287AAA7","A0A5F7ZYG4","GO:0030877; GO:0005938; GO:0071944; GO:0005737; GO:0031410; GO:0005829; GO:0016328; GO:0016020; GO:0015630; GO:0005634; GO:0048471; GO:0005886; GO:0032991; GO:1990909","GO:0070016; GO:0008013; GO:0019899; GO:0042802; GO:0070411; GO:0060090; GO:0002039; GO:0005515; GO:0008022; GO:0019904; GO:0042803; GO:0019901; GO:0043621; GO:0070412; GO:0035591; GO:0030159; GO:0046332; GO:0031625","GO:0032147; GO:0006915; GO:0048318; GO:0048320; GO:0060070; GO:0048468; GO:0031122; GO:0009950; GO:0009953; GO:0071514; GO:0060322; GO:0001701; GO:0090090; GO:0045599; GO:0010629; GO:0051248; GO:0034244; GO:0030178; GO:0006913; GO:0045893; GO:0046330; GO:0043507; GO:0033138; GO:0010800; GO:0032436; GO:0045732; GO:0045860; GO:0001934; GO:0031398; GO:0030511; GO:2000060; GO:0051443; GO:0036342; GO:0043161; GO:0030163; GO:0000209; GO:0065003; GO:0060828; GO:0001932; GO:0030111; GO:0007605; GO:0016055","PTHR46102:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=903|UniProtKB=O15169","P00005; P00057"]
["Axin1",null,"AXIN1","110","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2806",".ALZ., .ANG., .APO., .BRC., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .DEV., .DI., .EMC., .HIPPO., .JNK., .MAPK., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TGFB., .TRASR., .UBI., .WNT.","Angiogenesis; Wnt signaling pathway","AXIN-1","activation of protein kinase activity; apoptotic process; axial mesoderm development; axial mesoderm formation; canonical Wnt signaling pathway; cell development; cytoplasmic microtubule organization; dorsal/ventral axis specification; dorsal/ventral pattern formation; genomic imprinting; head development; in utero embryonic development; negative regulation of canonical Wnt signaling pathway; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of protein metabolic process; negative regulation of transcription elongation by RNA polymerase II; negative regulation of Wnt signaling pathway; nucleocytoplasmic transport; positive regulation of DNA-templated transcription; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein transferase activity; post-anal tail morphogenesis; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process; protein polyubiquitination; protein-containing complex assembly; regulation of canonical Wnt signaling pathway; regulation of protein phosphorylation; regulation of Wnt signaling pathway; sensory perception of sound; Wnt signaling pathway","armadillo repeat domain binding; beta-catenin binding; enzyme binding; identical protein binding; I-SMAD binding; molecular adaptor activity; p53 binding; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein self-association; R-SMAD binding; signaling adaptor activity; signaling receptor complex adaptor activity; SMAD binding; ubiquitin protein ligase binding","beta-catenin destruction complex; cell cortex; cell periphery; cytoplasm; cytoplasmic vesicle; cytosol; lateral plasma membrane; membrane; microtubule cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; Wnt signalosome","Wnt signaling","axin 1","http://www.ncbi.nlm.nih.gov/gene/?term=8312","8312","12005",null,null,null,"100424087","O15169","O35625",null,"A0A8I3Q4M1","A0A287AAA7","A0A5F7ZYG4","GO:0030877; GO:0005938; GO:0071944; GO:0005737; GO:0031410; GO:0005829; GO:0016328; GO:0016020; GO:0015630; GO:0005634; GO:0048471; GO:0005886; GO:0032991; GO:1990909","GO:0070016; GO:0008013; GO:0019899; GO:0042802; GO:0070411; GO:0060090; GO:0002039; GO:0005515; GO:0008022; GO:0019904; GO:0042803; GO:0019901; GO:0043621; GO:0070412; GO:0035591; GO:0030159; GO:0046332; GO:0031625","GO:0032147; GO:0006915; GO:0048318; GO:0048320; GO:0060070; GO:0048468; GO:0031122; GO:0009950; GO:0009953; GO:0071514; GO:0060322; GO:0001701; GO:0090090; GO:0045599; GO:0010629; GO:0051248; GO:0034244; GO:0030178; GO:0006913; GO:0045893; GO:0046330; GO:0043507; GO:0033138; GO:0010800; GO:0032436; GO:0045732; GO:0045860; GO:0001934; GO:0031398; GO:0030511; GO:2000060; GO:0051443; GO:0036342; GO:0043161; GO:0030163; GO:0000209; GO:0065003; GO:0060828; GO:0001932; GO:0030111; GO:0007605; GO:0016055","PTHR46102:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=903|UniProtKB=O15169","P00005; P00057"]
["Axin2 (Conductin)",null,"AXIN2","98, 95","rb",null,2,4,4,4,7,4,"# 2823",".ALZ., .ANG., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .DEV., .DI., .DREP., .EMC., .HIPPO., .OP., .OPA., .OT., .ST., .TRASR., .WNT.","Angiogenesis; Wnt signaling pathway","AXIN-2","aortic valve morphogenesis; bone mineralization; cell death; cell development; cell population proliferation; cellular response to dexamethasone stimulus; cellular response to organic cyclic compound; chondrocyte differentiation involved in endochondral bone morphogenesis; intramembranous ossification; maintenance of DNA repeat elements; mitral valve morphogenesis; mRNA stabilization; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; odontogenesis; osteoblast differentiation; osteoblast proliferation; positive regulation of cell death; positive regulation of epithelial to mesenchymal transition; positive regulation of fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; regulation of centromeric sister chromatid cohesion; regulation of chondrocyte development; regulation of extracellular matrix organization; regulation of mismatch repair; regulation of Wnt signaling pathway; response to steroid hormone; secondary heart field specification; somitogenesis; stem cell proliferation; Wnt signaling pathway","beta-catenin binding; enzyme binding; I-SMAD binding; molecular adaptor activity; protein binding; protein kinase binding; ubiquitin protein ligase binding","beta-catenin destruction complex; centrosome; cytoplasm; cytosol; nucleus; plasma membrane; protein-containing complex","Wnt signaling","axin 2","http://www.ncbi.nlm.nih.gov/gene/?term=8313","8313","12006","29134",null,null,null,"Q9Y2T1","O88566","O70240","A0A8I3SBJ2","A0A287BFQ6",null,"GO:0030877; GO:0005813; GO:0005737; GO:0005829; GO:0005634; GO:0005886; GO:0032991","GO:0008013; GO:0019899; GO:0070411; GO:0060090; GO:0005515; GO:0019901; GO:0031625","GO:0003180; GO:0030282; GO:0008219; GO:0048468; GO:0008283; GO:0071549; GO:0071407; GO:0003413; GO:0001957; GO:0043570; GO:0003183; GO:0048255; GO:0090090; GO:0008285; GO:0045668; GO:0033689; GO:2000054; GO:0042476; GO:0001649; GO:0033687; GO:0010942; GO:0010718; GO:0045600; GO:0032436; GO:0045860; GO:0001934; GO:0043161; GO:0008104; GO:0070602; GO:0061181; GO:1903053; GO:0032423; GO:0030111; GO:0048545; GO:0003139; GO:0001756; GO:0072089; GO:0016055","PTHR46102:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=904|UniProtKB=Q9Y2T1","P00005; P00057"]
["Axl",null,"AXL","138","rb",null,2,8,7,8,2.1,2,"# 1543",".APO., .CD., .CSP., .EGFR., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MIG., .OP., .OPA., .OT., .OXS., .PI3K., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS., .VIR.",null,"TYROSINE-PROTEIN KINASE RECEPTOR UFO","animal organ regeneration; apoptotic cell clearance; apoptotic process; blood vessel remodeling; cell differentiation; cell maturation; cell migration; cellular response to extracellular stimulus; cellular response to hydrogen peroxide; cellular response to interferon-alpha; cellular response to lipopolysaccharide; dendritic cell differentiation; enzyme-linked receptor protein signaling pathway; erythrocyte homeostasis; establishment of localization in cell; forebrain cell migration; immune system process; inflammatory response; innate immune response; lymphocyte activation; natural killer cell differentiation; negative regulation of apoptotic process; negative regulation of cytokine production; negative regulation of dendritic cell apoptotic process; negative regulation of lymphocyte activation; negative regulation of macrophage cytokine production; negative regulation of neuron apoptotic process; negative regulation of tumor necrosis factor production; negative regulation of type II interferon production; nervous system development; neuron apoptotic process; neuron migration; neutrophil clearance; ovulation cycle; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; platelet activation; positive regulation of cytokine-mediated signaling pathway; positive regulation of kinase activity; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; positive regulation of protein kinase B signaling; positive regulation of viral life cycle; protein kinase B signaling; protein phosphorylation; response to axon injury; secretion by cell; signal transduction; spermatogenesis; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway; vagina development; vascular endothelial growth factor receptor signaling pathway; viral entry into host cell","ATP binding; kinase activity; myosin heavy chain binding; nucleotide binding; phosphatidylinositol 3-kinase binding; phosphatidylserine binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; virus receptor activity","actin cytoskeleton; cell surface; extracellular exosome; extracellular space; intracellular membrane-bounded organelle; membrane; plasma membrane; receptor complex","Tyrosine kinase / adaptor","AXL receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=558","558","26362",null,null,null,null,"P30530","Q00993","A0A0G2K2H0","A0A8I3MH88",null,"A0A1D5Q330","GO:0015629; GO:0009986; GO:0070062; GO:0005615; GO:0043231; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0016301; GO:0032036; GO:0000166; GO:0043548; GO:0001786; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0001618","GO:0031100; GO:0043277; GO:0006915; GO:0001974; GO:0030154; GO:0048469; GO:0016477; GO:0031668; GO:0070301; GO:0035457; GO:0071222; GO:0097028; GO:0007167; GO:0034101; GO:0051649; GO:0021885; GO:0002376; GO:0006954; GO:0045087; GO:0046649; GO:0001779; GO:0043066; GO:0001818; GO:2000669; GO:0051250; GO:0010936; GO:0043524; GO:0032720; GO:0032689; GO:0007399; GO:0051402; GO:0001764; GO:0097350; GO:0042698; GO:0018108; GO:0006909; GO:0016310; GO:0030168; GO:0001961; GO:0033674; GO:0032825; GO:0048549; GO:0051897; GO:1903902; GO:0043491; GO:0006468; GO:0048678; GO:0032940; GO:0007165; GO:0007283; GO:0034446; GO:0007169; GO:0060068; GO:0048010; GO:0046718","PTHR24416:SF323","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=905|UniProtKB=P30530"]
["Axl - phospho","Tyr702","AXL","138","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1533",".APO., .CD., .CSP., .EGFR., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MIG., .OP., .OPA., .OT., .OXS., .PI3K., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS., .VIR.",null,"TYROSINE-PROTEIN KINASE RECEPTOR UFO","animal organ regeneration; apoptotic cell clearance; apoptotic process; blood vessel remodeling; cell differentiation; cell maturation; cell migration; cellular response to extracellular stimulus; cellular response to hydrogen peroxide; cellular response to interferon-alpha; cellular response to lipopolysaccharide; dendritic cell differentiation; enzyme-linked receptor protein signaling pathway; erythrocyte homeostasis; establishment of localization in cell; forebrain cell migration; immune system process; inflammatory response; innate immune response; lymphocyte activation; natural killer cell differentiation; negative regulation of apoptotic process; negative regulation of cytokine production; negative regulation of dendritic cell apoptotic process; negative regulation of lymphocyte activation; negative regulation of macrophage cytokine production; negative regulation of neuron apoptotic process; negative regulation of tumor necrosis factor production; negative regulation of type II interferon production; nervous system development; neuron apoptotic process; neuron migration; neutrophil clearance; ovulation cycle; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; platelet activation; positive regulation of cytokine-mediated signaling pathway; positive regulation of kinase activity; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; positive regulation of protein kinase B signaling; positive regulation of viral life cycle; protein kinase B signaling; protein phosphorylation; response to axon injury; secretion by cell; signal transduction; spermatogenesis; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway; vagina development; vascular endothelial growth factor receptor signaling pathway; viral entry into host cell","ATP binding; kinase activity; myosin heavy chain binding; nucleotide binding; phosphatidylinositol 3-kinase binding; phosphatidylserine binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; virus receptor activity","actin cytoskeleton; cell surface; extracellular exosome; extracellular space; intracellular membrane-bounded organelle; membrane; plasma membrane; receptor complex","Tyrosine kinase / adaptor","AXL receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=558","558","26362",null,null,null,null,"P30530","Q00993","A0A0G2K2H0","A0A8I3MH88",null,"A0A1D5Q330","GO:0015629; GO:0009986; GO:0070062; GO:0005615; GO:0043231; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0016301; GO:0032036; GO:0000166; GO:0043548; GO:0001786; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0001618","GO:0031100; GO:0043277; GO:0006915; GO:0001974; GO:0030154; GO:0048469; GO:0016477; GO:0031668; GO:0070301; GO:0035457; GO:0071222; GO:0097028; GO:0007167; GO:0034101; GO:0051649; GO:0021885; GO:0002376; GO:0006954; GO:0045087; GO:0046649; GO:0001779; GO:0043066; GO:0001818; GO:2000669; GO:0051250; GO:0010936; GO:0043524; GO:0032720; GO:0032689; GO:0007399; GO:0051402; GO:0001764; GO:0097350; GO:0042698; GO:0018108; GO:0006909; GO:0016310; GO:0030168; GO:0001961; GO:0033674; GO:0032825; GO:0048549; GO:0051897; GO:1903902; GO:0043491; GO:0006468; GO:0048678; GO:0032940; GO:0007165; GO:0007283; GO:0034446; GO:0007169; GO:0060068; GO:0048010; GO:0046718","PTHR24416:SF323","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=905|UniProtKB=P30530"]
["Bad",null,"BAD","23","rb",null,1.1000000000000001,4,4,4,4,4,"# 2454",".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DRR., .EGFR., .EMC., .GPCR., .HEPB., .HIF., .IMUF., .INFM., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .TCD., .TCR., .TMAT., .VEGFS.","CCKR signaling map","BCL2-ASSOCIATED AGONIST OF CELL DEATH","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; ADP metabolic process; apoptotic process; apoptotic signaling pathway; ATP metabolic process; cellular response to chromate; cellular response to hypoxia; cellular response to lipid; cellular response to mechanical stimulus; cellular response to nicotine; cerebral cortex development; cytokine-mediated signaling pathway; epithelial cell proliferation; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; glucose catabolic process; glucose homeostasis; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; pore complex assembly; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of B cell differentiation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of epithelial cell proliferation; positive regulation of glucokinase activity; positive regulation of granulosa cell apoptotic process; positive regulation of insulin secretion; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; positive regulation of mitochondrial membrane potential; positive regulation of neuron death; positive regulation of proteolysis; positive regulation of release of cytochrome c from mitochondria; positive regulation of T cell differentiation; positive regulation of type B pancreatic cell development; regulation of apoptotic process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of mitochondrial membrane permeability; release of cytochrome c from mitochondria; response to amino acid; response to benzene; response to calcium ion; response to estradiol; response to ethanol; response to glucocorticoid; response to glucose; response to hormone; response to hydrogen peroxide; response to hypoxia; response to oleic acid; response to organic cyclic compound; response to organic substance; response to progesterone; response to testosterone; response to xenobiotic stimulus; spermatogenesis; type B pancreatic cell proliferation","14-3-3 protein binding; cysteine-type endopeptidase activator activity involved in apoptotic process; lipid binding; phospholipid binding; protein binding; protein kinase B binding; protein kinase binding; protein phosphatase 2B binding; protein phosphatase binding","BAD-BCL-2 complex; cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion","Apoptosis","BCL2 associated agonist of cell death","http://www.ncbi.nlm.nih.gov/gene/?term=572","572","12015",null,"483763",null,null,"Q92934","Q61337","A0A8I6AQN1","Q45KI9","A0A287AEF3",null,"GO:0097138; GO:0005737; GO:0005829; GO:0016020; GO:0005741; GO:0005739","GO:0071889; GO:0008656; GO:0008289; GO:0005543; GO:0005515; GO:0043422; GO:0019901; GO:0030346; GO:0019903","GO:0097202; GO:0006919; GO:0046031; GO:0006915; GO:0097190; GO:0046034; GO:0071247; GO:0071456; GO:0071396; GO:0071260; GO:0071316; GO:0021987; GO:0019221; GO:0050673; GO:0097191; GO:0097192; GO:0008625; GO:0006007; GO:0042593; GO:0097193; GO:0008630; GO:0046931; GO:0043065; GO:0010508; GO:0045579; GO:0043280; GO:0050679; GO:0033133; GO:1904710; GO:0032024; GO:0035774; GO:1902220; GO:0010918; GO:1901216; GO:0045862; GO:0090200; GO:0045582; GO:2000078; GO:0042981; GO:0043281; GO:0046902; GO:0001836; GO:0043200; GO:1901423; GO:0051592; GO:0032355; GO:0045471; GO:0051384; GO:0009749; GO:0009725; GO:0042542; GO:0001666; GO:0034201; GO:0014070; GO:0010033; GO:0032570; GO:0033574; GO:0009410; GO:0007283; GO:0044342","PTHR28540:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=936|UniProtKB=Q92934","P06959"]
["Bad - phospho","Ser112","BAD","23","rb",null,1,4,4,4,4,4,"# 1197",".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DRR., .EGFR., .EMC., .GPCR., .HEPB., .HIF., .IMUF., .INFM., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .TCD., .TCR., .TMAT., .VEGFS.","CCKR signaling map","BCL2-ASSOCIATED AGONIST OF CELL DEATH","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; ADP metabolic process; apoptotic process; apoptotic signaling pathway; ATP metabolic process; cellular response to chromate; cellular response to hypoxia; cellular response to lipid; cellular response to mechanical stimulus; cellular response to nicotine; cerebral cortex development; cytokine-mediated signaling pathway; epithelial cell proliferation; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; glucose catabolic process; glucose homeostasis; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; pore complex assembly; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of B cell differentiation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of epithelial cell proliferation; positive regulation of glucokinase activity; positive regulation of granulosa cell apoptotic process; positive regulation of insulin secretion; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; positive regulation of mitochondrial membrane potential; positive regulation of neuron death; positive regulation of proteolysis; positive regulation of release of cytochrome c from mitochondria; positive regulation of T cell differentiation; positive regulation of type B pancreatic cell development; regulation of apoptotic process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of mitochondrial membrane permeability; release of cytochrome c from mitochondria; response to amino acid; response to benzene; response to calcium ion; response to estradiol; response to ethanol; response to glucocorticoid; response to glucose; response to hormone; response to hydrogen peroxide; response to hypoxia; response to oleic acid; response to organic cyclic compound; response to organic substance; response to progesterone; response to testosterone; response to xenobiotic stimulus; spermatogenesis; type B pancreatic cell proliferation","14-3-3 protein binding; cysteine-type endopeptidase activator activity involved in apoptotic process; lipid binding; phospholipid binding; protein binding; protein kinase B binding; protein kinase binding; protein phosphatase 2B binding; protein phosphatase binding","BAD-BCL-2 complex; cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion","Apoptosis","BCL2 associated agonist of cell death","http://www.ncbi.nlm.nih.gov/gene/?term=572","572","12015",null,"483763",null,null,"Q92934","Q61337","A0A8I6AQN1","Q45KI9","A0A287AEF3",null,"GO:0097138; GO:0005737; GO:0005829; GO:0016020; GO:0005741; GO:0005739","GO:0071889; GO:0008656; GO:0008289; GO:0005543; GO:0005515; GO:0043422; GO:0019901; GO:0030346; GO:0019903","GO:0097202; GO:0006919; GO:0046031; GO:0006915; GO:0097190; GO:0046034; GO:0071247; GO:0071456; GO:0071396; GO:0071260; GO:0071316; GO:0021987; GO:0019221; GO:0050673; GO:0097191; GO:0097192; GO:0008625; GO:0006007; GO:0042593; GO:0097193; GO:0008630; GO:0046931; GO:0043065; GO:0010508; GO:0045579; GO:0043280; GO:0050679; GO:0033133; GO:1904710; GO:0032024; GO:0035774; GO:1902220; GO:0010918; GO:1901216; GO:0045862; GO:0090200; GO:0045582; GO:2000078; GO:0042981; GO:0043281; GO:0046902; GO:0001836; GO:0043200; GO:1901423; GO:0051592; GO:0032355; GO:0045471; GO:0051384; GO:0009749; GO:0009725; GO:0042542; GO:0001666; GO:0034201; GO:0014070; GO:0010033; GO:0032570; GO:0033574; GO:0009410; GO:0007283; GO:0044342","PTHR28540:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=936|UniProtKB=Q92934","P06959"]
["Bad - phospho","Ser136","BAD","23","rb",null,1.1000000000000001,4,4,4,4,4,"# 2162",".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DRR., .EGFR., .EMC., .GPCR., .HEPB., .HIF., .IMUF., .INFM., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .TCD., .TCR., .TMAT., .VEGFS.","CCKR signaling map","BCL2-ASSOCIATED AGONIST OF CELL DEATH","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; ADP metabolic process; apoptotic process; apoptotic signaling pathway; ATP metabolic process; cellular response to chromate; cellular response to hypoxia; cellular response to lipid; cellular response to mechanical stimulus; cellular response to nicotine; cerebral cortex development; cytokine-mediated signaling pathway; epithelial cell proliferation; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; glucose catabolic process; glucose homeostasis; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; pore complex assembly; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of B cell differentiation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of epithelial cell proliferation; positive regulation of glucokinase activity; positive regulation of granulosa cell apoptotic process; positive regulation of insulin secretion; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; positive regulation of mitochondrial membrane potential; positive regulation of neuron death; positive regulation of proteolysis; positive regulation of release of cytochrome c from mitochondria; positive regulation of T cell differentiation; positive regulation of type B pancreatic cell development; regulation of apoptotic process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of mitochondrial membrane permeability; release of cytochrome c from mitochondria; response to amino acid; response to benzene; response to calcium ion; response to estradiol; response to ethanol; response to glucocorticoid; response to glucose; response to hormone; response to hydrogen peroxide; response to hypoxia; response to oleic acid; response to organic cyclic compound; response to organic substance; response to progesterone; response to testosterone; response to xenobiotic stimulus; spermatogenesis; type B pancreatic cell proliferation","14-3-3 protein binding; cysteine-type endopeptidase activator activity involved in apoptotic process; lipid binding; phospholipid binding; protein binding; protein kinase B binding; protein kinase binding; protein phosphatase 2B binding; protein phosphatase binding","BAD-BCL-2 complex; cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion","Apoptosis","BCL2 associated agonist of cell death","http://www.ncbi.nlm.nih.gov/gene/?term=572","572","12015",null,"483763",null,null,"Q92934","Q61337","A0A8I6AQN1","Q45KI9","A0A287AEF3",null,"GO:0097138; GO:0005737; GO:0005829; GO:0016020; GO:0005741; GO:0005739","GO:0071889; GO:0008656; GO:0008289; GO:0005543; GO:0005515; GO:0043422; GO:0019901; GO:0030346; GO:0019903","GO:0097202; GO:0006919; GO:0046031; GO:0006915; GO:0097190; GO:0046034; GO:0071247; GO:0071456; GO:0071396; GO:0071260; GO:0071316; GO:0021987; GO:0019221; GO:0050673; GO:0097191; GO:0097192; GO:0008625; GO:0006007; GO:0042593; GO:0097193; GO:0008630; GO:0046931; GO:0043065; GO:0010508; GO:0045579; GO:0043280; GO:0050679; GO:0033133; GO:1904710; GO:0032024; GO:0035774; GO:1902220; GO:0010918; GO:1901216; GO:0045862; GO:0090200; GO:0045582; GO:2000078; GO:0042981; GO:0043281; GO:0046902; GO:0001836; GO:0043200; GO:1901423; GO:0051592; GO:0032355; GO:0045471; GO:0051384; GO:0009749; GO:0009725; GO:0042542; GO:0001666; GO:0034201; GO:0014070; GO:0010033; GO:0032570; GO:0033574; GO:0009410; GO:0007283; GO:0044342","PTHR28540:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=936|UniProtKB=Q92934","P06959"]
["Bag1",null,"BAG1","52, 46, 33","ms",null,1,8,"n/a","n/a","n/a","n/a","# 2819",".APO., .CD., .CSP., .OPA., .ST.","Apoptosis signaling pathway","BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1","apoptotic process; cell surface receptor signaling pathway; chaperone cofactor-dependent protein refolding; negative regulation of apoptotic process; protein stabilization","adenyl-nucleotide exchange factor activity; chaperone binding; protein binding; ubiquitin protein ligase binding","cytoplasm; cytosol; membrane; nucleoplasm; nucleus",null,"BAG cochaperone 1","http://www.ncbi.nlm.nih.gov/gene/?term=573","573","12017",null,null,"100513225",null,"Q99933","Q60739","F1LRM5",null,"A0A5G2QPH3","A0A5F7ZFG8","GO:0005737; GO:0005829; GO:0016020; GO:0005654; GO:0005634","GO:0000774; GO:0051087; GO:0005515; GO:0031625","GO:0006915; GO:0007166; GO:0051085; GO:0043066; GO:0050821","PTHR12329:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=937|UniProtKB=Q99933","P00006"]
["Bag1",null,"BAG1","52, 46, 33","ms",null,1,8,"n/a","n/a","n/a","n/a","# 2854",".APO., .CD., .CSP., .OPA., .ST.","Apoptosis signaling pathway","BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1","apoptotic process; cell surface receptor signaling pathway; chaperone cofactor-dependent protein refolding; negative regulation of apoptotic process; protein stabilization","adenyl-nucleotide exchange factor activity; chaperone binding; protein binding; ubiquitin protein ligase binding","cytoplasm; cytosol; membrane; nucleoplasm; nucleus",null,"BAG cochaperone 1","http://www.ncbi.nlm.nih.gov/gene/?term=573","573","12017",null,null,"100513225",null,"Q99933","Q60739","F1LRM5",null,"A0A5G2QPH3","A0A5F7ZFG8","GO:0005737; GO:0005829; GO:0016020; GO:0005654; GO:0005634","GO:0000774; GO:0051087; GO:0005515; GO:0031625","GO:0006915; GO:0007166; GO:0051085; GO:0043066; GO:0050821","PTHR12329:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=937|UniProtKB=Q99933","P00006"]
["Bak",null,"BAK1","25","rb",null,2,7,"n/a","n/a","n/a","n/a","# 2633",".APO., .BCR., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DRR., .EMC., .GLI., .IMUF., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .SCLC., .SREME., .ST., .TRASR., .TYR.","Apoptosis signaling pathway","BCL-2 HOMOLOGOUS ANTAGONIST/KILLER","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; animal organ regeneration; apoptotic process; apoptotic process involved in blood vessel morphogenesis; apoptotic signaling pathway; B cell apoptotic process; B cell homeostasis; B cell negative selection; blood vessel remodeling; brain development; calcium ion transport into cytosol; cellular response to mechanical stimulus; cellular response to unfolded protein; cellular response to UV; endocrine pancreas development; endoplasmic reticulum calcium ion homeostasis; epithelial cell proliferation; establishment of localization in cell; establishment or maintenance of transmembrane electrochemical gradient; extrinsic apoptotic signaling pathway in absence of ligand; fibroblast apoptotic process; homeostasis of number of cells; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; leukocyte homeostasis; limb morphogenesis; mitochondrial fusion; myeloid cell homeostasis; negative regulation of cell population proliferation; negative regulation of endoplasmic reticulum calcium ion concentration; negative regulation of gene expression; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of release of cytochrome c from mitochondria; peptidyl-serine phosphorylation; positive regulation of apoptotic process; positive regulation of calcium ion transport into cytosol; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of IRE1-mediated unfolded protein response; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of protein-containing complex assembly; positive regulation of proteolysis; positive regulation of release of cytochrome c from mitochondria; post-embryonic camera-type eye morphogenesis; regulation of apoptotic process; regulation of apoptotic signaling pathway; regulation of cell cycle; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to ethanol; response to fungus; response to gamma radiation; response to hydrogen peroxide; response to mycotoxin; response to organic cyclic compound; response to UV-C; response to xenobiotic stimulus; thymocyte apoptotic process; vagina development","BH domain binding; chaperone binding; heat shock protein binding; identical protein binding; metal ion binding; molecular_function; protein binding; protein heterodimerization activity; protein homodimerization activity; protein-containing complex binding; transmembrane transporter binding","BAK complex; Bcl-2 family protein complex; cytosol; endoplasmic reticulum; membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; pore complex","Apoptosis","BCL2 antagonist/killer 1","http://www.ncbi.nlm.nih.gov/gene/?term=578","578","12018",null,null,null,null,"Q16611","O08734","F7EQF3","A0A8I3PJD5","A0A286ZMF6",null,"GO:0097145; GO:0097136; GO:0005829; GO:0005783; GO:0016020; GO:0031966; GO:0005741; GO:0005739; GO:0046930","GO:0051400; GO:0051087; GO:0031072; GO:0042802; GO:0046872; GO:0003674; GO:0005515; GO:0046982; GO:0042803; GO:0044877; GO:0044325","GO:0097202; GO:0006919; GO:0008635; GO:0007568; GO:0031100; GO:0006915; GO:1902262; GO:0097190; GO:0001783; GO:0001782; GO:0002352; GO:0001974; GO:0007420; GO:0060402; GO:0071260; GO:0034620; GO:0034644; GO:0031018; GO:0032469; GO:0050673; GO:0051649; GO:0010248; GO:0097192; GO:0044346; GO:0048872; GO:0008630; GO:0070059; GO:0001776; GO:0035108; GO:0008053; GO:0002262; GO:0008285; GO:0032471; GO:0010629; GO:1901029; GO:0033137; GO:0090201; GO:0018105; GO:0043065; GO:0010524; GO:1900103; GO:1903896; GO:1901030; GO:0031334; GO:0045862; GO:0090200; GO:0048597; GO:0042981; GO:2001233; GO:0051726; GO:0046902; GO:0051881; GO:0001836; GO:0045471; GO:0009620; GO:0010332; GO:0042542; GO:0010046; GO:0014070; GO:0010225; GO:0009410; GO:0070242; GO:0060068","PTHR11256:SF59","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=949|UniProtKB=Q16611","P00006"]
["Bax",null,"BAX","20","rb",null,2,2,2.1,7,2.1,7,"# 2455",".APO., .BCR., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .EGFR., .EMC., .GLI., .HEPB., .HUNT., .IMUF., .IMUR., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .RTK., .SCLC., .ST., .TYR., .VIR.","CCKR signaling map; p53 pathway; Huntington disease; Apoptosis signaling pathway","APOPTOSIS REGULATOR BAX","activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; apoptotic mitochondrial changes; apoptotic process; apoptotic process involved in blood vessel morphogenesis; apoptotic process involved in embryonic digit morphogenesis; apoptotic process involved in mammary gland involution; apoptotic signaling pathway; B cell apoptotic process; B cell homeostasis; B cell homeostatic proliferation; B cell negative selection; B cell receptor apoptotic signaling pathway; blood vessel remodeling; calcium ion transport into cytosol; cell population proliferation; cellular response to DNA damage stimulus; cellular response to organic substance; cellular response to unfolded protein; cellular response to UV; cellular response to virus; cerebral cortex development; development of secondary sexual characteristics; ectopic germ cell programmed cell death; endoplasmic reticulum calcium ion homeostasis; epithelial cell apoptotic process; epithelial cell proliferation; establishment of localization in cell; establishment or maintenance of transmembrane electrochemical gradient; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; fertilization; germ cell development; glycosphingolipid metabolic process; homeostasis of number of cells; homeostasis of number of cells within a tissue; hypothalamus development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; kidney development; leukocyte homeostasis; limb morphogenesis; male gonad development; mitochondrial fragmentation involved in apoptotic process; mitochondrial fusion; mitochondrion morphogenesis; motor neuron apoptotic process; myeloid cell homeostasis; negative regulation of apoptotic signaling pathway; negative regulation of cell population proliferation; negative regulation of endoplasmic reticulum calcium ion concentration; negative regulation of fibroblast proliferation; negative regulation of mitochondrial membrane potential; negative regulation of neuron apoptotic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; nervous system development; neuron apoptotic process; neuron migration; odontogenesis of dentin-containing tooth; ovarian follicle development; peptidyl-serine phosphorylation; positive regulation of apoptotic DNA fragmentation; positive regulation of apoptotic process; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of B cell apoptotic process; positive regulation of calcium ion transport into cytosol; positive regulation of developmental pigmentation; positive regulation of developmental process; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of epithelial cell apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of IRE1-mediated unfolded protein response; positive regulation of mitochondrial membrane permeability involved in apoptotic process; positive regulation of motor neuron apoptotic process; positive regulation of neuron apoptotic process; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of reproductive process; post-embryonic camera-type eye morphogenesis; post-embryonic development; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of apoptotic process; regulation of apoptotic signaling pathway; regulation of cell cycle; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of mammary gland epithelial cell proliferation; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; regulation of mitochondrial membrane potential; regulation of neuron apoptotic process; regulation of nitrogen utilization; release of cytochrome c from mitochondria; release of matrix enzymes from mitochondria; release of sequestered calcium ion into cytosol; response to axon injury; response to gamma radiation; response to ionizing radiation; response to salt stress; response to toxic substance; response to wounding; retina development in camera-type eye; retinal cell programmed cell death; Sertoli cell proliferation; sex differentiation; spermatid differentiation; spermatogenesis; supramolecular fiber organization; T cell homeostatic proliferation; thymocyte apoptotic process; vagina development","BH3 domain binding; channel activity; chaperone binding; Hsp70 protein binding; identical protein binding; lipid binding; protein binding; protein heterodimerization activity; protein homodimerization activity","BAK complex; BAX complex; Bcl-2 family protein complex; cell periphery; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular exosome; membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrial permeability transition pore complex; mitochondrion; nuclear envelope; nucleus; pore complex","Apoptosis","BCL2 associated X, apoptosis regulator","http://www.ncbi.nlm.nih.gov/gene/?term=581","581","12028","24887",null,"397337",null,"Q07812","Q07813","G3V8T9","A0A8I3MD65","Q9TV69","F6ZV71","GO:0097145; GO:0097144; GO:0097136; GO:0071944; GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0070062; GO:0016020; GO:0031966; GO:0005741; GO:0005757; GO:0005739; GO:0005635; GO:0005634; GO:0046930","GO:0051434; GO:0015267; GO:0051087; GO:0030544; GO:0042802; GO:0008289; GO:0005515; GO:0046982; GO:0042803","GO:0006919; GO:0008635; GO:0097296; GO:0008637; GO:0006915; GO:1902262; GO:1902263; GO:0060057; GO:0097190; GO:0001783; GO:0001782; GO:0002358; GO:0002352; GO:1990117; GO:0001974; GO:0060402; GO:0008283; GO:0006974; GO:0071310; GO:0034620; GO:0034644; GO:0098586; GO:0021987; GO:0045136; GO:0035234; GO:0032469; GO:1904019; GO:0050673; GO:0051649; GO:0010248; GO:0097191; GO:0097192; GO:0008625; GO:0009566; GO:0007281; GO:0006687; GO:0048872; GO:0048873; GO:0021854; GO:0097193; GO:0072332; GO:0008630; GO:0070059; GO:0001822; GO:0001776; GO:0035108; GO:0008584; GO:0043653; GO:0008053; GO:0070584; GO:0097049; GO:0002262; GO:2001234; GO:0008285; GO:0032471; GO:0048147; GO:0010917; GO:0043524; GO:0033137; GO:0032091; GO:0007399; GO:0051402; GO:0001764; GO:0042475; GO:0001541; GO:0018105; GO:1902512; GO:0043065; GO:0060058; GO:0002904; GO:0010524; GO:0048087; GO:0051094; GO:1900103; GO:1904037; GO:2001244; GO:1903896; GO:1902110; GO:2000673; GO:0043525; GO:0031334; GO:0090200; GO:0051281; GO:2000243; GO:0048597; GO:0009791; GO:0001844; GO:0042981; GO:2001233; GO:0051726; GO:0043281; GO:0033599; GO:1902108; GO:1902445; GO:0051881; GO:0043523; GO:0006808; GO:0001836; GO:0032976; GO:0051209; GO:0048678; GO:0010332; GO:0010212; GO:0009651; GO:0009636; GO:0009611; GO:0060041; GO:0046666; GO:0060011; GO:0007548; GO:0048515; GO:0007283; GO:0097435; GO:0001777; GO:0070242; GO:0060068","PTHR11256:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=959|UniProtKB=Q07812","P06959; P00059; P00029; P00006"]
["Bcl-2",null,"BCL2","26","rb",null,2,8,1,1,1.1000000000000001,1,"# 1821",".APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DRR., .EGFR., .HEPB., .HHSP., .HIF., .IMU., .IMUF., .IMUR., .MIG., .NFKB., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCD., .TCR., .TD., .TMAT., .TRASR., .UBI., .VIR.","CCKR signaling map; Oxidative stress response; Apoptosis signaling pathway","APOPTOSIS REGULATOR BCL-2","actin filament organization; animal organ morphogenesis; apoptotic mitochondrial changes; apoptotic process; axon regeneration; axonogenesis; B cell apoptotic process; B cell differentiation; B cell homeostasis; B cell lineage commitment; B cell proliferation; B cell receptor signaling pathway; behavioral fear response; branching involved in ureteric bud morphogenesis; calcium ion transport into cytosol; CD8-positive, alpha-beta T cell lineage commitment; cell migration; cell morphogenesis; cell population proliferation; cell-cell adhesion; cellular calcium ion homeostasis; cellular response to DNA damage stimulus; cellular response to glucose starvation; cellular response to hypoxia; cellular response to organic substance; cochlear nucleus development; defense response to virus; dendritic cell apoptotic process; developmental growth; developmental pigmentation; digestive tract morphogenesis; ear development; endoplasmic reticulum calcium ion homeostasis; epithelial cell apoptotic process; establishment of localization in cell; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; female pregnancy; focal adhesion assembly; G1/S transition of mitotic cell cycle; gland morphogenesis; glomerulus development; hair follicle morphogenesis; hematopoietic stem cell differentiation; hemopoiesis; homeostasis of number of cells within a tissue; humoral immune response; immune system development; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; kidney development; leukocyte homeostasis; lymphocyte apoptotic process; lymphocyte homeostasis; lymphoid progenitor cell differentiation; male gonad development; melanin metabolic process; melanocyte differentiation; mesenchymal cell development; metanephros development; mitotic cell cycle; motor neuron apoptotic process; myeloid cell apoptotic process; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of autophagy; negative regulation of B cell apoptotic process; negative regulation of calcium ion transport into cytosol; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of cellular pH reduction; negative regulation of dendritic cell apoptotic process; negative regulation of epithelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of lymphocyte apoptotic process; negative regulation of mitochondrial depolarization; negative regulation of mitotic cell cycle; negative regulation of motor neuron apoptotic process; negative regulation of myeloid cell apoptotic process; negative regulation of neuron apoptotic process; negative regulation of neuron death; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of reactive oxygen species metabolic process; negative regulation of retinal cell programmed cell death; negative regulation of T cell apoptotic process; neuron apoptotic process; neuron death; neuron maturation; oocyte development; organ growth; ossification; osteoblast proliferation; ovarian follicle development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pigment granule organization; pigmentation; positive regulation of apoptotic process; positive regulation of B cell proliferation; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of developmental pigmentation; positive regulation of melanocyte differentiation; positive regulation of multicellular organism growth; positive regulation of neuron maturation; positive regulation of peptidyl-serine phosphorylation; positive regulation of skeletal muscle fiber development; positive regulation of smooth muscle cell migration; post-embryonic development; protein dephosphorylation; protein polyubiquitination; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of apoptotic signaling pathway; regulation of autophagy; regulation of calcium ion transport; regulation of catalytic activity; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of developmental pigmentation; regulation of gene expression; regulation of glycoprotein biosynthetic process; regulation of growth; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; regulation of programmed cell death; regulation of protein localization; regulation of protein stability; regulation of transmembrane transporter activity; regulation of viral genome replication; release of cytochrome c from mitochondria; renal system process; response to amino acid; response to cytokine; response to external stimulus; response to gamma radiation; response to glucocorticoid; response to hydrogen peroxide; response to iron ion; response to ischemia; response to nicotine; response to organic cyclic compound; response to oxidative stress; response to radiation; response to steroid hormone; response to toxic substance; response to UV-B; response to xenobiotic stimulus; retinal cell programmed cell death; skeletal muscle fiber development; smooth muscle cell migration; spleen development; stem cell development; T cell apoptotic process; T cell differentiation; T cell differentiation in thymus; T cell homeostasis; T cell lineage commitment; thymus development; ureteric bud development","BH3 domain binding; channel activity; channel inhibitor activity; DNA-binding transcription factor binding; identical protein binding; molecular adaptor activity; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein phosphatase 2A binding; protein phosphatase binding; sequence-specific DNA binding; ubiquitin protein ligase binding","BAD-BCL-2 complex; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nuclear membrane; nucleoplasm; nucleus; pore complex; protein-containing complex","Apoptosis","BCL2 apoptosis regulator","http://www.ncbi.nlm.nih.gov/gene/?term=596","596","12043",null,null,null,null,"P10415","P10417",null,"A0A8I3MLT5",null,null,"GO:0097138; GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0031966; GO:0005741; GO:0005739; GO:0043209; GO:0031965; GO:0005654; GO:0005634; GO:0046930; GO:0032991","GO:0051434; GO:0015267; GO:0016248; GO:0140297; GO:0042802; GO:0060090; GO:0002020; GO:0005515; GO:0046982; GO:0042803; GO:0051721; GO:0019903; GO:0043565; GO:0031625","GO:0007015; GO:0009887; GO:0008637; GO:0006915; GO:0031103; GO:0007409; GO:0001783; GO:0030183; GO:0001782; GO:0002326; GO:0042100; GO:0050853; GO:0001662; GO:0001658; GO:0060402; GO:0043375; GO:0016477; GO:0000902; GO:0008283; GO:0098609; GO:0006874; GO:0006974; GO:0042149; GO:0071456; GO:0071310; GO:0021747; GO:0051607; GO:0097048; GO:0048589; GO:0048066; GO:0048546; GO:0043583; GO:0032469; GO:1904019; GO:0051649; GO:0097192; GO:0008625; GO:0007565; GO:0048041; GO:0000082; GO:0022612; GO:0032835; GO:0031069; GO:0060218; GO:0030097; GO:0048873; GO:0006959; GO:0002520; GO:0008630; GO:0070059; GO:0008631; GO:0001822; GO:0001776; GO:0070227; GO:0002260; GO:0002320; GO:0008584; GO:0006582; GO:0030318; GO:0014031; GO:0001656; GO:0000278; GO:0097049; GO:0033028; GO:2000811; GO:0043066; GO:2001234; GO:0010507; GO:0002903; GO:0010523; GO:0030308; GO:0030336; GO:0008285; GO:0032848; GO:2000669; GO:1904036; GO:2001240; GO:2000134; GO:2001243; GO:1902166; GO:0070229; GO:0051902; GO:0045930; GO:2000672; GO:0033033; GO:0043524; GO:1901215; GO:0030279; GO:0033689; GO:2000378; GO:0046671; GO:0070233; GO:0051402; GO:0070997; GO:0042551; GO:0048599; GO:0035265; GO:0001503; GO:0033687; GO:0001541; GO:0018105; GO:0018107; GO:0048753; GO:0043473; GO:0043065; GO:0030890; GO:0043085; GO:0030307; GO:0008284; GO:0048087; GO:0045636; GO:0040018; GO:0014042; GO:0033138; GO:0048743; GO:0014911; GO:0009791; GO:0006470; GO:0000209; GO:0072593; GO:0042981; GO:2001233; GO:0010506; GO:0051924; GO:0050790; GO:0051726; GO:0001952; GO:0048070; GO:0010468; GO:0010559; GO:0040008; GO:0046902; GO:0051881; GO:0006808; GO:0043067; GO:0032880; GO:0031647; GO:0022898; GO:0045069; GO:0001836; GO:0003014; GO:0043200; GO:0034097; GO:0009605; GO:0010332; GO:0051384; GO:0042542; GO:0010039; GO:0002931; GO:0035094; GO:0014070; GO:0006979; GO:0009314; GO:0048545; GO:0009636; GO:0010224; GO:0009410; GO:0046666; GO:0048741; GO:0014909; GO:0048536; GO:0048864; GO:0070231; GO:0030217; GO:0033077; GO:0043029; GO:0002360; GO:0048538; GO:0001657","PTHR11256:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=990|UniProtKB=P10415","P06959; P00046; P00006"]
["Bcl-2",null,"BCL2","26","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2456",".APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DRR., .EGFR., .HEPB., .HHSP., .HIF., .IMU., .IMUF., .IMUR., .MIG., .NFKB., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCD., .TCR., .TD., .TMAT., .TRASR., .UBI., .VIR.","CCKR signaling map; Oxidative stress response; Apoptosis signaling pathway","APOPTOSIS REGULATOR BCL-2","actin filament organization; animal organ morphogenesis; apoptotic mitochondrial changes; apoptotic process; axon regeneration; axonogenesis; B cell apoptotic process; B cell differentiation; B cell homeostasis; B cell lineage commitment; B cell proliferation; B cell receptor signaling pathway; behavioral fear response; branching involved in ureteric bud morphogenesis; calcium ion transport into cytosol; CD8-positive, alpha-beta T cell lineage commitment; cell migration; cell morphogenesis; cell population proliferation; cell-cell adhesion; cellular calcium ion homeostasis; cellular response to DNA damage stimulus; cellular response to glucose starvation; cellular response to hypoxia; cellular response to organic substance; cochlear nucleus development; defense response to virus; dendritic cell apoptotic process; developmental growth; developmental pigmentation; digestive tract morphogenesis; ear development; endoplasmic reticulum calcium ion homeostasis; epithelial cell apoptotic process; establishment of localization in cell; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; female pregnancy; focal adhesion assembly; G1/S transition of mitotic cell cycle; gland morphogenesis; glomerulus development; hair follicle morphogenesis; hematopoietic stem cell differentiation; hemopoiesis; homeostasis of number of cells within a tissue; humoral immune response; immune system development; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; kidney development; leukocyte homeostasis; lymphocyte apoptotic process; lymphocyte homeostasis; lymphoid progenitor cell differentiation; male gonad development; melanin metabolic process; melanocyte differentiation; mesenchymal cell development; metanephros development; mitotic cell cycle; motor neuron apoptotic process; myeloid cell apoptotic process; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of autophagy; negative regulation of B cell apoptotic process; negative regulation of calcium ion transport into cytosol; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of cellular pH reduction; negative regulation of dendritic cell apoptotic process; negative regulation of epithelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of lymphocyte apoptotic process; negative regulation of mitochondrial depolarization; negative regulation of mitotic cell cycle; negative regulation of motor neuron apoptotic process; negative regulation of myeloid cell apoptotic process; negative regulation of neuron apoptotic process; negative regulation of neuron death; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of reactive oxygen species metabolic process; negative regulation of retinal cell programmed cell death; negative regulation of T cell apoptotic process; neuron apoptotic process; neuron death; neuron maturation; oocyte development; organ growth; ossification; osteoblast proliferation; ovarian follicle development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pigment granule organization; pigmentation; positive regulation of apoptotic process; positive regulation of B cell proliferation; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of developmental pigmentation; positive regulation of melanocyte differentiation; positive regulation of multicellular organism growth; positive regulation of neuron maturation; positive regulation of peptidyl-serine phosphorylation; positive regulation of skeletal muscle fiber development; positive regulation of smooth muscle cell migration; post-embryonic development; protein dephosphorylation; protein polyubiquitination; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of apoptotic signaling pathway; regulation of autophagy; regulation of calcium ion transport; regulation of catalytic activity; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of developmental pigmentation; regulation of gene expression; regulation of glycoprotein biosynthetic process; regulation of growth; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; regulation of programmed cell death; regulation of protein localization; regulation of protein stability; regulation of transmembrane transporter activity; regulation of viral genome replication; release of cytochrome c from mitochondria; renal system process; response to amino acid; response to cytokine; response to external stimulus; response to gamma radiation; response to glucocorticoid; response to hydrogen peroxide; response to iron ion; response to ischemia; response to nicotine; response to organic cyclic compound; response to oxidative stress; response to radiation; response to steroid hormone; response to toxic substance; response to UV-B; response to xenobiotic stimulus; retinal cell programmed cell death; skeletal muscle fiber development; smooth muscle cell migration; spleen development; stem cell development; T cell apoptotic process; T cell differentiation; T cell differentiation in thymus; T cell homeostasis; T cell lineage commitment; thymus development; ureteric bud development","BH3 domain binding; channel activity; channel inhibitor activity; DNA-binding transcription factor binding; identical protein binding; molecular adaptor activity; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein phosphatase 2A binding; protein phosphatase binding; sequence-specific DNA binding; ubiquitin protein ligase binding","BAD-BCL-2 complex; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nuclear membrane; nucleoplasm; nucleus; pore complex; protein-containing complex","Apoptosis","BCL2 apoptosis regulator","http://www.ncbi.nlm.nih.gov/gene/?term=596","596","12043",null,null,null,null,"P10415","P10417",null,"A0A8I3MLT5",null,null,"GO:0097138; GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0031966; GO:0005741; GO:0005739; GO:0043209; GO:0031965; GO:0005654; GO:0005634; GO:0046930; GO:0032991","GO:0051434; GO:0015267; GO:0016248; GO:0140297; GO:0042802; GO:0060090; GO:0002020; GO:0005515; GO:0046982; GO:0042803; GO:0051721; GO:0019903; GO:0043565; GO:0031625","GO:0007015; GO:0009887; GO:0008637; GO:0006915; GO:0031103; GO:0007409; GO:0001783; GO:0030183; GO:0001782; GO:0002326; GO:0042100; GO:0050853; GO:0001662; GO:0001658; GO:0060402; GO:0043375; GO:0016477; GO:0000902; GO:0008283; GO:0098609; GO:0006874; GO:0006974; GO:0042149; GO:0071456; GO:0071310; GO:0021747; GO:0051607; GO:0097048; GO:0048589; GO:0048066; GO:0048546; GO:0043583; GO:0032469; GO:1904019; GO:0051649; GO:0097192; GO:0008625; GO:0007565; GO:0048041; GO:0000082; GO:0022612; GO:0032835; GO:0031069; GO:0060218; GO:0030097; GO:0048873; GO:0006959; GO:0002520; GO:0008630; GO:0070059; GO:0008631; GO:0001822; GO:0001776; GO:0070227; GO:0002260; GO:0002320; GO:0008584; GO:0006582; GO:0030318; GO:0014031; GO:0001656; GO:0000278; GO:0097049; GO:0033028; GO:2000811; GO:0043066; GO:2001234; GO:0010507; GO:0002903; GO:0010523; GO:0030308; GO:0030336; GO:0008285; GO:0032848; GO:2000669; GO:1904036; GO:2001240; GO:2000134; GO:2001243; GO:1902166; GO:0070229; GO:0051902; GO:0045930; GO:2000672; GO:0033033; GO:0043524; GO:1901215; GO:0030279; GO:0033689; GO:2000378; GO:0046671; GO:0070233; GO:0051402; GO:0070997; GO:0042551; GO:0048599; GO:0035265; GO:0001503; GO:0033687; GO:0001541; GO:0018105; GO:0018107; GO:0048753; GO:0043473; GO:0043065; GO:0030890; GO:0043085; GO:0030307; GO:0008284; GO:0048087; GO:0045636; GO:0040018; GO:0014042; GO:0033138; GO:0048743; GO:0014911; GO:0009791; GO:0006470; GO:0000209; GO:0072593; GO:0042981; GO:2001233; GO:0010506; GO:0051924; GO:0050790; GO:0051726; GO:0001952; GO:0048070; GO:0010468; GO:0010559; GO:0040008; GO:0046902; GO:0051881; GO:0006808; GO:0043067; GO:0032880; GO:0031647; GO:0022898; GO:0045069; GO:0001836; GO:0003014; GO:0043200; GO:0034097; GO:0009605; GO:0010332; GO:0051384; GO:0042542; GO:0010039; GO:0002931; GO:0035094; GO:0014070; GO:0006979; GO:0009314; GO:0048545; GO:0009636; GO:0010224; GO:0009410; GO:0046666; GO:0048741; GO:0014909; GO:0048536; GO:0048864; GO:0070231; GO:0030217; GO:0033077; GO:0043029; GO:0002360; GO:0048538; GO:0001657","PTHR11256:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=990|UniProtKB=P10415","P06959; P00046; P00006"]
["Bcl-2 - phospho","Ser70","BCL2","28","rb",null,4,4,4,4,4,4,"# 0681",".APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DRR., .EGFR., .HEPB., .HHSP., .HIF., .IMU., .IMUF., .IMUR., .MIG., .NFKB., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCD., .TCR., .TD., .TMAT., .TRASR., .UBI., .VIR.","CCKR signaling map; Oxidative stress response; Apoptosis signaling pathway","APOPTOSIS REGULATOR BCL-2","actin filament organization; animal organ morphogenesis; apoptotic mitochondrial changes; apoptotic process; axon regeneration; axonogenesis; B cell apoptotic process; B cell differentiation; B cell homeostasis; B cell lineage commitment; B cell proliferation; B cell receptor signaling pathway; behavioral fear response; branching involved in ureteric bud morphogenesis; calcium ion transport into cytosol; CD8-positive, alpha-beta T cell lineage commitment; cell migration; cell morphogenesis; cell population proliferation; cell-cell adhesion; cellular calcium ion homeostasis; cellular response to DNA damage stimulus; cellular response to glucose starvation; cellular response to hypoxia; cellular response to organic substance; cochlear nucleus development; defense response to virus; dendritic cell apoptotic process; developmental growth; developmental pigmentation; digestive tract morphogenesis; ear development; endoplasmic reticulum calcium ion homeostasis; epithelial cell apoptotic process; establishment of localization in cell; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; female pregnancy; focal adhesion assembly; G1/S transition of mitotic cell cycle; gland morphogenesis; glomerulus development; hair follicle morphogenesis; hematopoietic stem cell differentiation; hemopoiesis; homeostasis of number of cells within a tissue; humoral immune response; immune system development; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; kidney development; leukocyte homeostasis; lymphocyte apoptotic process; lymphocyte homeostasis; lymphoid progenitor cell differentiation; male gonad development; melanin metabolic process; melanocyte differentiation; mesenchymal cell development; metanephros development; mitotic cell cycle; motor neuron apoptotic process; myeloid cell apoptotic process; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of autophagy; negative regulation of B cell apoptotic process; negative regulation of calcium ion transport into cytosol; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of cellular pH reduction; negative regulation of dendritic cell apoptotic process; negative regulation of epithelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of lymphocyte apoptotic process; negative regulation of mitochondrial depolarization; negative regulation of mitotic cell cycle; negative regulation of motor neuron apoptotic process; negative regulation of myeloid cell apoptotic process; negative regulation of neuron apoptotic process; negative regulation of neuron death; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of reactive oxygen species metabolic process; negative regulation of retinal cell programmed cell death; negative regulation of T cell apoptotic process; neuron apoptotic process; neuron death; neuron maturation; oocyte development; organ growth; ossification; osteoblast proliferation; ovarian follicle development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pigment granule organization; pigmentation; positive regulation of apoptotic process; positive regulation of B cell proliferation; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of developmental pigmentation; positive regulation of melanocyte differentiation; positive regulation of multicellular organism growth; positive regulation of neuron maturation; positive regulation of peptidyl-serine phosphorylation; positive regulation of skeletal muscle fiber development; positive regulation of smooth muscle cell migration; post-embryonic development; protein dephosphorylation; protein polyubiquitination; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of apoptotic signaling pathway; regulation of autophagy; regulation of calcium ion transport; regulation of catalytic activity; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of developmental pigmentation; regulation of gene expression; regulation of glycoprotein biosynthetic process; regulation of growth; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; regulation of programmed cell death; regulation of protein localization; regulation of protein stability; regulation of transmembrane transporter activity; regulation of viral genome replication; release of cytochrome c from mitochondria; renal system process; response to amino acid; response to cytokine; response to external stimulus; response to gamma radiation; response to glucocorticoid; response to hydrogen peroxide; response to iron ion; response to ischemia; response to nicotine; response to organic cyclic compound; response to oxidative stress; response to radiation; response to steroid hormone; response to toxic substance; response to UV-B; response to xenobiotic stimulus; retinal cell programmed cell death; skeletal muscle fiber development; smooth muscle cell migration; spleen development; stem cell development; T cell apoptotic process; T cell differentiation; T cell differentiation in thymus; T cell homeostasis; T cell lineage commitment; thymus development; ureteric bud development","BH3 domain binding; channel activity; channel inhibitor activity; DNA-binding transcription factor binding; identical protein binding; molecular adaptor activity; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein phosphatase 2A binding; protein phosphatase binding; sequence-specific DNA binding; ubiquitin protein ligase binding","BAD-BCL-2 complex; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nuclear membrane; nucleoplasm; nucleus; pore complex; protein-containing complex","Apoptosis","BCL2 apoptosis regulator","http://www.ncbi.nlm.nih.gov/gene/?term=596","596","12043",null,null,null,null,"P10415","P10417",null,"A0A8I3MLT5",null,null,"GO:0097138; GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0031966; GO:0005741; GO:0005739; GO:0043209; GO:0031965; GO:0005654; GO:0005634; GO:0046930; GO:0032991","GO:0051434; GO:0015267; GO:0016248; GO:0140297; GO:0042802; GO:0060090; GO:0002020; GO:0005515; GO:0046982; GO:0042803; GO:0051721; GO:0019903; GO:0043565; GO:0031625","GO:0007015; GO:0009887; GO:0008637; GO:0006915; GO:0031103; GO:0007409; GO:0001783; GO:0030183; GO:0001782; GO:0002326; GO:0042100; GO:0050853; GO:0001662; GO:0001658; GO:0060402; GO:0043375; GO:0016477; GO:0000902; GO:0008283; GO:0098609; GO:0006874; GO:0006974; GO:0042149; GO:0071456; GO:0071310; GO:0021747; GO:0051607; GO:0097048; GO:0048589; GO:0048066; GO:0048546; GO:0043583; GO:0032469; GO:1904019; GO:0051649; GO:0097192; GO:0008625; GO:0007565; GO:0048041; GO:0000082; GO:0022612; GO:0032835; GO:0031069; GO:0060218; GO:0030097; GO:0048873; GO:0006959; GO:0002520; GO:0008630; GO:0070059; GO:0008631; GO:0001822; GO:0001776; GO:0070227; GO:0002260; GO:0002320; GO:0008584; GO:0006582; GO:0030318; GO:0014031; GO:0001656; GO:0000278; GO:0097049; GO:0033028; GO:2000811; GO:0043066; GO:2001234; GO:0010507; GO:0002903; GO:0010523; GO:0030308; GO:0030336; GO:0008285; GO:0032848; GO:2000669; GO:1904036; GO:2001240; GO:2000134; GO:2001243; GO:1902166; GO:0070229; GO:0051902; GO:0045930; GO:2000672; GO:0033033; GO:0043524; GO:1901215; GO:0030279; GO:0033689; GO:2000378; GO:0046671; GO:0070233; GO:0051402; GO:0070997; GO:0042551; GO:0048599; GO:0035265; GO:0001503; GO:0033687; GO:0001541; GO:0018105; GO:0018107; GO:0048753; GO:0043473; GO:0043065; GO:0030890; GO:0043085; GO:0030307; GO:0008284; GO:0048087; GO:0045636; GO:0040018; GO:0014042; GO:0033138; GO:0048743; GO:0014911; GO:0009791; GO:0006470; GO:0000209; GO:0072593; GO:0042981; GO:2001233; GO:0010506; GO:0051924; GO:0050790; GO:0051726; GO:0001952; GO:0048070; GO:0010468; GO:0010559; GO:0040008; GO:0046902; GO:0051881; GO:0006808; GO:0043067; GO:0032880; GO:0031647; GO:0022898; GO:0045069; GO:0001836; GO:0003014; GO:0043200; GO:0034097; GO:0009605; GO:0010332; GO:0051384; GO:0042542; GO:0010039; GO:0002931; GO:0035094; GO:0014070; GO:0006979; GO:0009314; GO:0048545; GO:0009636; GO:0010224; GO:0009410; GO:0046666; GO:0048741; GO:0014909; GO:0048536; GO:0048864; GO:0070231; GO:0030217; GO:0033077; GO:0043029; GO:0002360; GO:0048538; GO:0001657","PTHR11256:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=990|UniProtKB=P10415","P06959; P00046; P00006"]
["Bcl6",null,"BCL6","98-87","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1515",".APO., .BCR., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .FOXO., .IMFR., .IMU., .IMUF., .IMUR., .NOTCH., .OP., .OPA., .OT., .RAS., .RTK., .TCD., .TCR., .TMAT., .TRASR.",null,"B-CELL LYMPHOMA 6 PROTEIN","actin cytoskeleton organization; B cell differentiation; B cell proliferation; cell morphogenesis; cell population proliferation; cell-matrix adhesion; cellular response to DNA damage stimulus; erythrocyte development; germinal center formation; histone deacetylation; immune system process; inflammatory response; isotype switching to IgE isotypes; leukocyte proliferation; negative regulation of apoptotic process; negative regulation of B cell apoptotic process; negative regulation of cell growth; negative regulation of cell-matrix adhesion; negative regulation of cellular senescence; negative regulation of DNA-templated transcription; negative regulation of isotype switching to IgE isotypes; negative regulation of leukocyte proliferation; negative regulation of mast cell cytokine production; negative regulation of mitotic cell cycle DNA replication; negative regulation of Notch signaling pathway; negative regulation of plasma cell differentiation; negative regulation of Rho protein signal transduction; negative regulation of T-helper 2 cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of type 2 immune response; plasma cell differentiation; positive regulation of apoptotic process; positive regulation of B cell proliferation; positive regulation of histone deacetylation; positive regulation of neuron differentiation; positive regulation of regulatory T cell differentiation; protein localization; pyramidal neuron differentiation; regulation of cell differentiation; regulation of cell population proliferation; regulation of cytokine production; regulation of germinal center formation; regulation of GTPase activity; regulation of immune response; regulation of immune system process; regulation of inflammatory response; regulation of memory T cell differentiation; regulation of T cell proliferation; regulation of transcription by RNA polymerase II; Rho protein signal transduction; spermatogenesis; T-helper 2 cell differentiation; transcription by RNA polymerase II; type 2 immune response","chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding; intronic transcription regulatory region sequence-specific DNA binding; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription corepressor binding","Golgi apparatus; nucleolus; nucleoplasm; nucleus; paraspeckles; replication fork","Lymphocyte signaling","BCL6 transcription repressor","http://www.ncbi.nlm.nih.gov/gene/?term=604","604","12053","303836",null,null,null,"P41182","P41183","B2GUV8","A0A8I3PH71","A0A287AXN0","A0A5F8AAP2","GO:0005794; GO:0005730; GO:0005654; GO:0005634; GO:0042382; GO:0005657","GO:0003682; GO:0031490; GO:0003677; GO:0003700; GO:0140297; GO:0001227; GO:0042802; GO:0001161; GO:0046872; GO:0005515; GO:0000978; GO:0000977; GO:0043565; GO:1990837; GO:0001222","GO:0030036; GO:0030183; GO:0042100; GO:0000902; GO:0008283; GO:0007160; GO:0006974; GO:0048821; GO:0002467; GO:0016575; GO:0002376; GO:0006954; GO:0048289; GO:0070661; GO:0043066; GO:0002903; GO:0030308; GO:0001953; GO:2000773; GO:0045892; GO:0048294; GO:0070664; GO:0032764; GO:1903464; GO:0045746; GO:1900099; GO:0035024; GO:0045629; GO:0000122; GO:0002829; GO:0002317; GO:0043065; GO:0030890; GO:0031065; GO:0045666; GO:0045591; GO:0008104; GO:0021859; GO:0045595; GO:0042127; GO:0001817; GO:0002634; GO:0043087; GO:0050776; GO:0002682; GO:0050727; GO:0043380; GO:0042129; GO:0006357; GO:0007266; GO:0007283; GO:0045064; GO:0006366; GO:0042092","PTHR24399:SF29","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1001|UniProtKB=P41182"]
["Bcl-xL",null,"BCL2L1","30","rb",null,1,2,1,1,2,2,"# 2636",".APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DRR., .EGFR., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .RAS., .RTK., .SCLC., .ST., .STAT., .VIR.","CCKR signaling map; Apoptosis signaling pathway","BCL-2-LIKE PROTEIN 1","apoptotic mitochondrial changes; apoptotic process; apoptotic process in bone marrow cell; cellular response to alkaloid; cellular response to amino acid stimulus; cellular response to gamma radiation; defense response to virus; dendritic cell apoptotic process; dendritic cell proliferation; ectopic germ cell programmed cell death; endocytosis; epithelial cell proliferation; extrinsic apoptotic signaling pathway in absence of ligand; fertilization; germ cell development; hepatocyte apoptotic process; in utero embryonic development; intrinsic apoptotic signaling pathway in response to DNA damage; male gonad development; mitochondrion morphogenesis; negative regulation of apoptotic process; negative regulation of dendritic cell apoptotic process; negative regulation of developmental process; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of execution phase of apoptosis; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of neuron apoptotic process; negative regulation of protein localization to plasma membrane; negative regulation of release of cytochrome c from mitochondria; negative regulation of reproductive process; neuron apoptotic process; ovarian follicle development; positive regulation of mononuclear cell proliferation; regulation of apoptotic process; regulation of apoptotic signaling pathway; regulation of cytokinesis; regulation of growth; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to cycloheximide; response to cytokine; response to external stimulus; response to radiation; response to virus; spermatogenesis; suppression by virus of host apoptotic process","BH3 domain binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding","Bcl-2 family protein complex; centrosome; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endoplasmic reticulum; membrane; microtubule organizing center; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nuclear membrane; nucleus; synapse; synaptic vesicle membrane","Apoptosis","BCL2 like 1","http://www.ncbi.nlm.nih.gov/gene/?term=598","598","12048",null,"403618",null,null,"Q07817","Q64373","E9PU78","Q76LT7",null,"A0A5F7ZJK5","GO:0097136; GO:0005813; GO:0005737; GO:0031410; GO:0005856; GO:0005829; GO:0005783; GO:0016020; GO:0005815; GO:0005743; GO:0005759; GO:0031966; GO:0005741; GO:0005739; GO:0031965; GO:0005634; GO:0045202; GO:0030672","GO:0051434; GO:0042802; GO:0005515; GO:0046982; GO:0042803; GO:0019901","GO:0008637; GO:0006915; GO:0071839; GO:0071312; GO:0071230; GO:0071480; GO:0051607; GO:0097048; GO:0044565; GO:0035234; GO:0006897; GO:0050673; GO:0097192; GO:0009566; GO:0007281; GO:0097284; GO:0001701; GO:0008630; GO:0008584; GO:0070584; GO:0043066; GO:2000669; GO:0051093; GO:1902236; GO:1900118; GO:2001240; GO:1902042; GO:2001243; GO:1902230; GO:0043524; GO:1903077; GO:0090201; GO:2000242; GO:0051402; GO:0001541; GO:0032946; GO:0042981; GO:2001233; GO:0032465; GO:0040008; GO:0046902; GO:0051881; GO:0001836; GO:0046898; GO:0034097; GO:0009605; GO:0009314; GO:0009615; GO:0007283; GO:0019050","PTHR11256:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=992|UniProtKB=Q07817","P06959; P00006"]
["Beclin-1",null,"BECN1","60","rb",null,1,2,1.1000000000000001,8,1.1000000000000001,1.1000000000000001,"# 0611",".ALZ., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .DI., .DRR., .EGFR., .HIF., .HUNT., .IMUR., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .ST., .VIR.",null,"BECLIN-1","aging; amyloid-beta metabolic process; apoptotic process; autophagosome assembly; autophagosome maturation; autophagy; autophagy of mitochondrion; cell cycle; cell division; cellular defense response; cellular response to aluminum ion; cellular response to amino acid starvation; cellular response to copper ion; cellular response to epidermal growth factor stimulus; cellular response to glucose starvation; cellular response to hydrogen peroxide; cellular response to nitrogen starvation; cellular response to stress; defense response to virus; early endosome to late endosome transport; endocytosis; engulfment of apoptotic cell; late endosome to vacuole transport; lysosome organization; macroautophagy; mitophagy; mitotic metaphase plate congression; negative regulation of apoptotic process; negative regulation of autophagosome assembly; negative regulation of autophagy; negative regulation of cell death; negative regulation of cell population proliferation; negative regulation of lysosome organization; negative regulation of reactive oxygen species metabolic process; neuron development; phosphatidylinositol-3-phosphate biosynthetic process; positive regulation of attachment of mitotic spindle microtubules to kinetochore; positive regulation of autophagosome assembly; positive regulation of autophagy; positive regulation of cardiac muscle hypertrophy; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; protein phosphorylation; protein targeting to lysosome; receptor catabolic process; regulation of autophagy; regulation of catalytic activity; regulation of cytokinesis; regulation of macroautophagy; regulation of response to stimulus; response to hypoxia; response to iron(II) ion; response to lead ion; response to mitochondrial depolarisation; response to nutrient levels; response to other organism; response to vitamin E; response to xenobiotic stimulus; selective autophagy; suppression by virus of host autophagy","GTPase binding; identical protein binding; phosphatidylinositol 3-kinase binding; protein binding; protein kinase binding; ubiquitin protein ligase binding","autophagosome; cytoplasm; cytoplasmic vesicle; cytosol; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extrinsic component of membrane; Golgi apparatus; membrane; mitochondrial membrane; mitochondrion; nuclear body; nucleus; phagocytic vesicle; phagophore assembly site; phosphatidylinositol 3-kinase complex, class III; phosphatidylinositol 3-kinase complex, class III, type I; phosphatidylinositol 3-kinase complex, class III, type II; protein-containing complex; trans-Golgi network","Autophagy","beclin 1","http://www.ncbi.nlm.nih.gov/gene/?term=8678","8678","56208","114558",null,"733576",null,"Q14457","O88597","Q91XJ1",null,"A0A287BIH8","A0A1D5R9M3","GO:0005776; GO:0005737; GO:0031410; GO:0005829; GO:0030425; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0019898; GO:0005794; GO:0016020; GO:0031966; GO:0005739; GO:0016604; GO:0005634; GO:0045335; GO:0000407; GO:0035032; GO:0034271; GO:0034272; GO:0032991; GO:0005802","GO:0051020; GO:0042802; GO:0043548; GO:0005515; GO:0019901; GO:0031625","GO:0007568; GO:0050435; GO:0006915; GO:0000045; GO:0097352; GO:0006914; GO:0000422; GO:0007049; GO:0051301; GO:0006968; GO:0071275; GO:0034198; GO:0071280; GO:0071364; GO:0042149; GO:0070301; GO:0006995; GO:0033554; GO:0051607; GO:0045022; GO:0006897; GO:0043652; GO:0045324; GO:0007040; GO:0016236; GO:0000423; GO:0007080; GO:0043066; GO:1902902; GO:0010507; GO:0060548; GO:0008285; GO:1905672; GO:2000378; GO:0048666; GO:0036092; GO:1902425; GO:2000786; GO:0010508; GO:0010613; GO:2001244; GO:0014068; GO:0006468; GO:0006622; GO:0032801; GO:0010506; GO:0050790; GO:0032465; GO:0016241; GO:0048583; GO:0001666; GO:0010040; GO:0010288; GO:0098780; GO:0031667; GO:0051707; GO:0033197; GO:0009410; GO:0061912; GO:0039521","PTHR12768:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1034|UniProtKB=Q14457"]
["BEND3 (c-term)",null,"BEND3","94","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1699",".OP., .OT., .TRASR.",null,"BEN DOMAIN-CONTAINING PROTEIN 3","chromatin organization; DNA methylation; histone H3-K27 trimethylation; histone H3-K4 trimethylation; histone H3-K9 trimethylation; histone H4 acetylation; histone H4-K20 trimethylation; negative regulation of transcription by RNA polymerase II; positive regulation of ATP metabolic process; protein homooligomerization; rDNA heterochromatin formation","DNA binding; protein binding; rDNA binding","heterochromatin; nucleolus; nucleoplasm; nucleus",null,"BEN domain containing 3","http://www.ncbi.nlm.nih.gov/gene/?term=57673","57673","331623","683923",null,null,null,"Q5T5X7","Q6PAL0","M0RCL1","A0A8I3N8X7",null,null,"GO:0000792; GO:0005730; GO:0005654; GO:0005634","GO:0003677; GO:0005515; GO:0000182","GO:0006325; GO:0006306; GO:0098532; GO:0080182; GO:0036124; GO:0043967; GO:0034773; GO:0000122; GO:1903580; GO:0051260; GO:0000183","PTHR28665:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=23040|UniProtKB=Q5T5X7"]
["Beta-2-microglobulin",null,"B2M","14","rb",null,2,2,2,8,2,2,"# 0332",".CCP., .CP., .CSP., .DRR., .IMU., .IMUF., .IMUR., .OP., .OT., .TCR.","T cell activation","BETA-2-MICROGLOBULIN","amyloid fibril formation; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cellular response to iron ion; cellular response to iron(III) ion; cellular response to nicotine; immune response; immune system process; iron ion homeostasis; iron ion transport; learning or memory; negative regulation of epithelial cell proliferation; negative regulation of forebrain neuron differentiation; negative regulation of neurogenesis; negative regulation of neuron projection development; negative regulation of receptor binding; peptide antigen assembly with MHC class II protein complex; positive regulation of cellular senescence; positive regulation of ferrous iron binding; positive regulation of protein binding; positive regulation of receptor binding; positive regulation of receptor-mediated endocytosis; positive regulation of T cell activation; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; positive regulation of transferrin receptor binding; protein homotetramerization; protein refolding; regulation of erythrocyte differentiation; regulation of iron ion transport; response to molecule of bacterial origin; retina homeostasis; sensory perception of smell; T cell differentiation in thymus; T cell mediated cytotoxicity","identical protein binding; MHC class II protein complex binding; protein binding; protein homodimerization activity","cell surface; cytosol; early endosome lumen; early endosome membrane; endoplasmic reticulum lumen; ER to Golgi transport vesicle membrane; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; HFE-transferrin receptor complex; membrane; MHC class I peptide loading complex; MHC class I protein complex; MHC class II protein complex; phagocytic vesicle membrane; plasma membrane; recycling endosome membrane; specific granule lumen; tertiary granule lumen","Immunology","beta-2-microglobulin","http://www.ncbi.nlm.nih.gov/gene/?term=567","567","12010","24223",null,"397033",null,"P61769","P01887","P07151","A0A8I3PXH7","Q07717",null,"GO:0009986; GO:0005829; GO:0031905; GO:0031901; GO:0005788; GO:0012507; GO:0009897; GO:0070062; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0000139; GO:1990712; GO:0016020; GO:0042824; GO:0042612; GO:0042613; GO:0030670; GO:0005886; GO:0055038; GO:0035580; GO:1904724","GO:0042802; GO:0023026; GO:0005515; GO:0042803","GO:1990000; GO:0019885; GO:0019886; GO:0002481; GO:0002474; GO:0071281; GO:0071283; GO:0071316; GO:0006955; GO:0002376; GO:0055072; GO:0006826; GO:0007611; GO:0050680; GO:2000978; GO:0050768; GO:0010977; GO:1900121; GO:0002503; GO:2000774; GO:1904434; GO:0032092; GO:1900122; GO:0048260; GO:0050870; GO:0002726; GO:0001916; GO:1904437; GO:0051289; GO:0042026; GO:0045646; GO:0034756; GO:0002237; GO:0001895; GO:0007608; GO:0033077; GO:0001913","PTHR19944:SF62","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=914|UniProtKB=P61769","P00053"]
["beta-Actin",null,"ACTB","42","ms",null,1,1,1,1,1,1,"# 2104",".ALZ., .APO., .CADH., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .DREP., .HIPPO., .HUNT., .IMUF., .INFM., .INT., .OP., .OPA., .OT., .PLAT., .TCD., .TCR., .TMAT., .TRASR., .WNT.","Huntington disease; Nicotinic acetylcholine receptor signaling pathway; Alzheimer disease-presenilin pathway; Cytoskeletal regulation by Rho GTPase; Cadherin signaling pathway; Integrin signalling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","ACTIN, CYTOPLASMIC 1","adherens junction assembly; apical protein localization; axonogenesis; cell motility; cellular response to cytochalasin B; chromatin remodeling; establishment or maintenance of cell polarity; histone acetylation; histone H2A acetylation; histone H4 acetylation; maintenance of blood-brain barrier; morphogenesis of a polarized epithelium; negative regulation of cell differentiation; negative regulation of protein binding; platelet aggregation; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of double-strand break repair via homologous recombination; positive regulation of myoblast differentiation; positive regulation of norepinephrine uptake; positive regulation of stem cell population maintenance; positive regulation of T cell differentiation; postsynaptic actin cytoskeleton organization; protein localization to adherens junction; regulation of apoptotic process; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of double-strand break repair; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of norepinephrine uptake; regulation of nucleotide-excision repair; regulation of protein localization to plasma membrane; regulation of synaptic vesicle endocytosis; regulation of transcription by RNA polymerase II; regulation of transepithelial transport; regulation of transmembrane transporter activity; retina homeostasis; substantia nigra development","ATP binding; hydrolase activity; identical protein binding; kinesin binding; nitric-oxide synthase binding; nucleosomal DNA binding; nucleotide binding; protein binding; protein kinase binding; structural constituent of cytoskeleton; structural constituent of postsynaptic actin cytoskeleton; Tat protein binding; tau protein binding","actin cytoskeleton; actin filament; adherens junction; apical junction complex; axon; bBAF complex; blood microparticle; brahma complex; brush border; calyx of Held; cell-cell junction; chromatin; cortical cytoskeleton; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; dense body; extracellular exosome; extracellular space; focal adhesion; GBAF complex; glutamatergic synapse; kinetochore; lamellipodium; membrane; nBAF complex; npBAF complex; NuA4 histone acetyltransferase complex; nuclear matrix; nucleoplasm; nucleosome; nucleus; plasma membrane; postsynaptic actin cytoskeleton; presynapse; protein-containing complex; ribonucleoprotein complex; RSC-type complex; Schaffer collateral - CA1 synapse; SWI/SNF complex; synapse; tight junction; vesicle","Cytoskeletal regulation / Adhesion","actin beta","http://www.ncbi.nlm.nih.gov/gene/?term=60","60","11461","81822","403580","414396",null,"P60709","P60710","P60711","O18840","Q6QAQ1","A0A1D5QZ28","GO:0015629; GO:0005884; GO:0005912; GO:0043296; GO:0030424; GO:0140092; GO:0072562; GO:0035060; GO:0005903; GO:0044305; GO:0005911; GO:0000785; GO:0030863; GO:0005737; GO:0036464; GO:0005856; GO:0005829; GO:0097433; GO:0070062; GO:0005615; GO:0005925; GO:0140288; GO:0098978; GO:0000776; GO:0030027; GO:0016020; GO:0071565; GO:0071564; GO:0035267; GO:0016363; GO:0005654; GO:0000786; GO:0005634; GO:0005886; GO:0098871; GO:0098793; GO:0032991; GO:1990904; GO:0016586; GO:0098685; GO:0016514; GO:0045202; GO:0070160; GO:0031982","GO:0005524; GO:0016787; GO:0042802; GO:0019894; GO:0050998; GO:0031492; GO:0000166; GO:0005515; GO:0019901; GO:0005200; GO:0098973; GO:0030957; GO:0048156","GO:0034333; GO:0045176; GO:0007409; GO:0048870; GO:0072749; GO:0006338; GO:0007163; GO:0016573; GO:0043968; GO:0043967; GO:0035633; GO:0001738; GO:0045596; GO:0032091; GO:0070527; GO:0045597; GO:0008284; GO:0045893; GO:2000781; GO:1905168; GO:0045663; GO:0051623; GO:1902459; GO:0045582; GO:0098974; GO:0071896; GO:0042981; GO:0051726; GO:0000079; GO:2000779; GO:0070316; GO:2000045; GO:0030071; GO:0051621; GO:2000819; GO:1903076; GO:1900242; GO:0006357; GO:0150111; GO:0022898; GO:0001895; GO:0021762","PTHR11937:SF414","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=132|UniProtKB=P60709","P00029; P00044; P00004; P00016; P00012; P00034; P00031; P00057"]
["beta-Catenin",null,"CTNNB1","92","rb",null,1,1,1,1,1,1,"# 3120",".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Angiogenesis; p53 pathway feedback loops 2; Wnt signaling pathway","CATENIN BETA-1","acinar cell differentiation; adherens junction assembly; adherens junction organization; animal organ development; anterior/posterior axis specification; apoptotic signaling pathway; astrocyte-dopaminergic neuron signaling; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in osteoblast differentiation; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell differentiation; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell population proliferation; cell-cell adhesion; cell-matrix adhesion; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chemical synaptic transmission; chondrocyte differentiation; cranial ganglion development; cranial skeletal system development; detection of muscle stretch; DNA-templated transcription; dorsal root ganglion development; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic organ development; embryonic skeletal limb joint morphogenesis; endoderm formation; endodermal cell fate commitment; endothelial tube morphogenesis; epithelial cell differentiation involved in prostate gland development; epithelial cell proliferation involved in prostate gland development; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain development; fungiform papilla formation; gastrulation with mouth forming second; genitalia morphogenesis; glandular epithelial cell differentiation; glial cell fate determination; hair cell differentiation; hair cycle process; hair follicle morphogenesis; hair follicle placode formation; heart development; hemopoiesis; hindbrain development; hypothalamus development; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; kidney development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; limb development; lung cell differentiation; lung development; lung epithelial cell differentiation; lung induction; lung-associated mesenchyme development; male genitalia development; MAPK cascade; mesenchymal cell proliferation; mesenchymal cell proliferation involved in lung development; mesenchymal stem cell differentiation; metanephros morphogenesis; midbrain development; midbrain dopaminergic neuron differentiation; morphogenesis of embryonic epithelium; myoblast proliferation; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron death; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; nephron tubule formation; nervous system development; neural plate development; neuroblast proliferation; neuron differentiation; neuron fate determination; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; oocyte development; osteoblast differentiation; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of branching involved in lung morphogenesis; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of molecular function; positive regulation of myoblast proliferation; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of stem cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of angiogenesis; regulation of apoptotic process; regulation of calcium ion import; regulation of cell differentiation; regulation of cell population proliferation; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of core promoter binding; regulation of epithelial cell differentiation; regulation of fibroblast proliferation; regulation of gene expression; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of synapse assembly; regulation of T cell proliferation; regulation of timing of anagen; regulation of transcription by RNA polymerase II; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to estradiol; response to xenobiotic stimulus; skeletal system development; skin development; smooth muscle cell differentiation; stem cell population maintenance; stem cell proliferation; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation; T cell differentiation in thymus; thymus development; tissue homeostasis; trachea formation; trachea morphogenesis; transcription by RNA polymerase II; vasculature development; vasculogenesis; Wnt signaling pathway","alpha-catenin binding; beta-catenin binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor binding; enzyme binding; histone methyltransferase binding; I-SMAD binding; kinase binding; nuclear estrogen receptor binding; nuclear receptor binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription coactivator activity; transcription coregulator binding; transcription corepressor binding; transmembrane transporter binding","adherens junction; anchoring junction; apical junction complex; apical part of cell; apicolateral plasma membrane; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-ICAT complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell projection; cell projection membrane; cell-cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; euchromatin; extracellular exosome; fascia adherens; flotillin complex; focal adhesion; glutamatergic synapse; intercalated disc; lamellipodium; lateral plasma membrane; membrane; microtubule organizing center; microvillus membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; RNA polymerase II transcription regulator complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription regulator complex; Wnt signalosome; Z disc","Wnt signaling","catenin beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=1499","1499","12387","84353",null,null,null,"P35222","Q02248","A0A0G2JT93","A0A8I3NUM7","A0A287AJ73","A0A5F7ZEY4","GO:0005912; GO:0070161; GO:0043296; GO:0045177; GO:0016327; GO:0016323; GO:0030877; GO:1990711; GO:1990907; GO:0070369; GO:0005923; GO:0016342; GO:0005938; GO:0030054; GO:0071944; GO:0042995; GO:0031253; GO:0005911; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0000791; GO:0070062; GO:0005916; GO:0016600; GO:0005925; GO:0098978; GO:0014704; GO:0030027; GO:0016328; GO:0016020; GO:0005815; GO:0031528; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0099092; GO:0045211; GO:0098831; GO:0042734; GO:0032991; GO:0032993; GO:0090575; GO:0098685; GO:0034750; GO:0000922; GO:0045202; GO:0005667; GO:1990909; GO:0030018","GO:0045294; GO:0008013; GO:0045296; GO:0003682; GO:0097718; GO:0140297; GO:0019899; GO:1990226; GO:0070411; GO:0019900; GO:0030331; GO:0016922; GO:0005515; GO:0008022; GO:0019901; GO:0019903; GO:0061629; GO:0046332; GO:0003713; GO:0001221; GO:0001222; GO:0044325","GO:0090425; GO:0034333; GO:0034332; GO:0048513; GO:0009948; GO:0097190; GO:0036520; GO:0045453; GO:0001569; GO:0001658; GO:0060070; GO:0044338; GO:1904954; GO:0044336; GO:0044339; GO:0061324; GO:0044334; GO:0007155; GO:0030154; GO:0001708; GO:0048469; GO:0000904; GO:0008283; GO:0098609; GO:0007160; GO:0071363; GO:0071681; GO:0022009; GO:0007268; GO:0002062; GO:0061550; GO:1904888; GO:0035995; GO:0006351; GO:1990791; GO:0009950; GO:0009953; GO:0007398; GO:0000578; GO:1990403; GO:0042733; GO:0048617; GO:0035115; GO:0035050; GO:0035116; GO:0048568; GO:0036023; GO:0001706; GO:0001711; GO:0061154; GO:0060742; GO:0060767; GO:0001837; GO:0060441; GO:0008543; GO:0030900; GO:0061198; GO:0001702; GO:0035112; GO:0002067; GO:0007403; GO:0035315; GO:0022405; GO:0031069; GO:0060789; GO:0007507; GO:0030097; GO:0030902; GO:0021854; GO:0007249; GO:0001701; GO:0001822; GO:0021819; GO:0002089; GO:0060173; GO:0060479; GO:0030324; GO:0060487; GO:0060492; GO:0060484; GO:0030539; GO:0000165; GO:0010463; GO:0060916; GO:0072497; GO:0003338; GO:0030901; GO:1904948; GO:0016331; GO:0051450; GO:0016525; GO:0043066; GO:2001234; GO:0090090; GO:0045596; GO:0008285; GO:0032331; GO:0045892; GO:0010629; GO:0003340; GO:0045976; GO:0050768; GO:1901215; GO:0048715; GO:0045671; GO:1903204; GO:0033234; GO:0000122; GO:0072079; GO:0007399; GO:0001840; GO:0007405; GO:0030182; GO:0048664; GO:0001764; GO:1990138; GO:0042475; GO:0048709; GO:0048599; GO:0001649; GO:0030316; GO:0060066; GO:0031016; GO:0043065; GO:0061047; GO:0045597; GO:0008284; GO:1904798; GO:2000017; GO:0051091; GO:0045893; GO:0045603; GO:0030858; GO:0060769; GO:0010718; GO:0045743; GO:0010628; GO:0010909; GO:0051571; GO:0043123; GO:0043410; GO:0002053; GO:0044093; GO:2000288; GO:2000179; GO:0002052; GO:0043525; GO:0045669; GO:0048643; GO:2000648; GO:0051973; GO:0032212; GO:0045944; GO:0032968; GO:0043161; GO:0008104; GO:0034394; GO:0000209; GO:0009954; GO:0045765; GO:0042981; GO:0090279; GO:0045595; GO:0042127; GO:0030997; GO:0070602; GO:1904796; GO:0030856; GO:0048145; GO:0010468; GO:0031641; GO:0072182; GO:0050767; GO:0045667; GO:0045670; GO:2000008; GO:0003266; GO:0048660; GO:0051963; GO:0042129; GO:0051884; GO:0006357; GO:0072053; GO:0072054; GO:0072033; GO:0032355; GO:0009410; GO:0001501; GO:0043588; GO:0051145; GO:0019827; GO:0072089; GO:0061549; GO:0050808; GO:0097091; GO:0048489; GO:0030217; GO:0033077; GO:0048538; GO:0001894; GO:0060440; GO:0060439; GO:0006366; GO:0001944; GO:0001570; GO:0016055","PTHR45976:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2514|UniProtKB=P35222","P06959; P06664; P00004; P00012; P00005; P04398; P00057"]
["beta-Catenin - phospho","Ser33/Ser37/Thr41","CTNNB1","92","rb",null,1,5,"n/a","n/a","n/a","n/a","# 2458",".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Angiogenesis; p53 pathway feedback loops 2; Wnt signaling pathway","CATENIN BETA-1","acinar cell differentiation; adherens junction assembly; adherens junction organization; animal organ development; anterior/posterior axis specification; apoptotic signaling pathway; astrocyte-dopaminergic neuron signaling; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in osteoblast differentiation; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell differentiation; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell population proliferation; cell-cell adhesion; cell-matrix adhesion; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chemical synaptic transmission; chondrocyte differentiation; cranial ganglion development; cranial skeletal system development; detection of muscle stretch; DNA-templated transcription; dorsal root ganglion development; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic organ development; embryonic skeletal limb joint morphogenesis; endoderm formation; endodermal cell fate commitment; endothelial tube morphogenesis; epithelial cell differentiation involved in prostate gland development; epithelial cell proliferation involved in prostate gland development; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain development; fungiform papilla formation; gastrulation with mouth forming second; genitalia morphogenesis; glandular epithelial cell differentiation; glial cell fate determination; hair cell differentiation; hair cycle process; hair follicle morphogenesis; hair follicle placode formation; heart development; hemopoiesis; hindbrain development; hypothalamus development; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; kidney development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; limb development; lung cell differentiation; lung development; lung epithelial cell differentiation; lung induction; lung-associated mesenchyme development; male genitalia development; MAPK cascade; mesenchymal cell proliferation; mesenchymal cell proliferation involved in lung development; mesenchymal stem cell differentiation; metanephros morphogenesis; midbrain development; midbrain dopaminergic neuron differentiation; morphogenesis of embryonic epithelium; myoblast proliferation; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron death; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; nephron tubule formation; nervous system development; neural plate development; neuroblast proliferation; neuron differentiation; neuron fate determination; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; oocyte development; osteoblast differentiation; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of branching involved in lung morphogenesis; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of molecular function; positive regulation of myoblast proliferation; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of stem cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of angiogenesis; regulation of apoptotic process; regulation of calcium ion import; regulation of cell differentiation; regulation of cell population proliferation; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of core promoter binding; regulation of epithelial cell differentiation; regulation of fibroblast proliferation; regulation of gene expression; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of synapse assembly; regulation of T cell proliferation; regulation of timing of anagen; regulation of transcription by RNA polymerase II; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to estradiol; response to xenobiotic stimulus; skeletal system development; skin development; smooth muscle cell differentiation; stem cell population maintenance; stem cell proliferation; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation; T cell differentiation in thymus; thymus development; tissue homeostasis; trachea formation; trachea morphogenesis; transcription by RNA polymerase II; vasculature development; vasculogenesis; Wnt signaling pathway","alpha-catenin binding; beta-catenin binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor binding; enzyme binding; histone methyltransferase binding; I-SMAD binding; kinase binding; nuclear estrogen receptor binding; nuclear receptor binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription coactivator activity; transcription coregulator binding; transcription corepressor binding; transmembrane transporter binding","adherens junction; anchoring junction; apical junction complex; apical part of cell; apicolateral plasma membrane; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-ICAT complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell projection; cell projection membrane; cell-cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; euchromatin; extracellular exosome; fascia adherens; flotillin complex; focal adhesion; glutamatergic synapse; intercalated disc; lamellipodium; lateral plasma membrane; membrane; microtubule organizing center; microvillus membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; RNA polymerase II transcription regulator complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription regulator complex; Wnt signalosome; Z disc","Wnt signaling","catenin beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=1499","1499","12387","84353",null,null,null,"P35222","Q02248","A0A0G2JT93","A0A8I3NUM7","A0A287AJ73","A0A5F7ZEY4","GO:0005912; GO:0070161; GO:0043296; GO:0045177; GO:0016327; GO:0016323; GO:0030877; GO:1990711; GO:1990907; GO:0070369; GO:0005923; GO:0016342; GO:0005938; GO:0030054; GO:0071944; GO:0042995; GO:0031253; GO:0005911; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0000791; GO:0070062; GO:0005916; GO:0016600; GO:0005925; GO:0098978; GO:0014704; GO:0030027; GO:0016328; GO:0016020; GO:0005815; GO:0031528; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0099092; GO:0045211; GO:0098831; GO:0042734; GO:0032991; GO:0032993; GO:0090575; GO:0098685; GO:0034750; GO:0000922; GO:0045202; GO:0005667; GO:1990909; GO:0030018","GO:0045294; GO:0008013; GO:0045296; GO:0003682; GO:0097718; GO:0140297; GO:0019899; GO:1990226; GO:0070411; GO:0019900; GO:0030331; GO:0016922; GO:0005515; GO:0008022; GO:0019901; GO:0019903; GO:0061629; GO:0046332; GO:0003713; GO:0001221; GO:0001222; GO:0044325","GO:0090425; GO:0034333; GO:0034332; GO:0048513; GO:0009948; GO:0097190; GO:0036520; GO:0045453; GO:0001569; GO:0001658; GO:0060070; GO:0044338; GO:1904954; GO:0044336; GO:0044339; GO:0061324; GO:0044334; GO:0007155; GO:0030154; GO:0001708; GO:0048469; GO:0000904; GO:0008283; GO:0098609; GO:0007160; GO:0071363; GO:0071681; GO:0022009; GO:0007268; GO:0002062; GO:0061550; GO:1904888; GO:0035995; GO:0006351; GO:1990791; GO:0009950; GO:0009953; GO:0007398; GO:0000578; GO:1990403; GO:0042733; GO:0048617; GO:0035115; GO:0035050; GO:0035116; GO:0048568; GO:0036023; GO:0001706; GO:0001711; GO:0061154; GO:0060742; GO:0060767; GO:0001837; GO:0060441; GO:0008543; GO:0030900; GO:0061198; GO:0001702; GO:0035112; GO:0002067; GO:0007403; GO:0035315; GO:0022405; GO:0031069; GO:0060789; GO:0007507; GO:0030097; GO:0030902; GO:0021854; GO:0007249; GO:0001701; GO:0001822; GO:0021819; GO:0002089; GO:0060173; GO:0060479; GO:0030324; GO:0060487; GO:0060492; GO:0060484; GO:0030539; GO:0000165; GO:0010463; GO:0060916; GO:0072497; GO:0003338; GO:0030901; GO:1904948; GO:0016331; GO:0051450; GO:0016525; GO:0043066; GO:2001234; GO:0090090; GO:0045596; GO:0008285; GO:0032331; GO:0045892; GO:0010629; GO:0003340; GO:0045976; GO:0050768; GO:1901215; GO:0048715; GO:0045671; GO:1903204; GO:0033234; GO:0000122; GO:0072079; GO:0007399; GO:0001840; GO:0007405; GO:0030182; GO:0048664; GO:0001764; GO:1990138; GO:0042475; GO:0048709; GO:0048599; GO:0001649; GO:0030316; GO:0060066; GO:0031016; GO:0043065; GO:0061047; GO:0045597; GO:0008284; GO:1904798; GO:2000017; GO:0051091; GO:0045893; GO:0045603; GO:0030858; GO:0060769; GO:0010718; GO:0045743; GO:0010628; GO:0010909; GO:0051571; GO:0043123; GO:0043410; GO:0002053; GO:0044093; GO:2000288; GO:2000179; GO:0002052; GO:0043525; GO:0045669; GO:0048643; GO:2000648; GO:0051973; GO:0032212; GO:0045944; GO:0032968; GO:0043161; GO:0008104; GO:0034394; GO:0000209; GO:0009954; GO:0045765; GO:0042981; GO:0090279; GO:0045595; GO:0042127; GO:0030997; GO:0070602; GO:1904796; GO:0030856; GO:0048145; GO:0010468; GO:0031641; GO:0072182; GO:0050767; GO:0045667; GO:0045670; GO:2000008; GO:0003266; GO:0048660; GO:0051963; GO:0042129; GO:0051884; GO:0006357; GO:0072053; GO:0072054; GO:0072033; GO:0032355; GO:0009410; GO:0001501; GO:0043588; GO:0051145; GO:0019827; GO:0072089; GO:0061549; GO:0050808; GO:0097091; GO:0048489; GO:0030217; GO:0033077; GO:0048538; GO:0001894; GO:0060440; GO:0060439; GO:0006366; GO:0001944; GO:0001570; GO:0016055","PTHR45976:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2514|UniProtKB=P35222","P06959; P06664; P00004; P00012; P00005; P04398; P00057"]
["beta-Catenin - phospho","Ser45","CTNNB1","92","rb",null,2.1,4,4,4,4,4,"# 0952",".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Angiogenesis; p53 pathway feedback loops 2; Wnt signaling pathway","CATENIN BETA-1","acinar cell differentiation; adherens junction assembly; adherens junction organization; animal organ development; anterior/posterior axis specification; apoptotic signaling pathway; astrocyte-dopaminergic neuron signaling; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in osteoblast differentiation; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell differentiation; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell population proliferation; cell-cell adhesion; cell-matrix adhesion; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chemical synaptic transmission; chondrocyte differentiation; cranial ganglion development; cranial skeletal system development; detection of muscle stretch; DNA-templated transcription; dorsal root ganglion development; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic organ development; embryonic skeletal limb joint morphogenesis; endoderm formation; endodermal cell fate commitment; endothelial tube morphogenesis; epithelial cell differentiation involved in prostate gland development; epithelial cell proliferation involved in prostate gland development; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain development; fungiform papilla formation; gastrulation with mouth forming second; genitalia morphogenesis; glandular epithelial cell differentiation; glial cell fate determination; hair cell differentiation; hair cycle process; hair follicle morphogenesis; hair follicle placode formation; heart development; hemopoiesis; hindbrain development; hypothalamus development; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; kidney development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; limb development; lung cell differentiation; lung development; lung epithelial cell differentiation; lung induction; lung-associated mesenchyme development; male genitalia development; MAPK cascade; mesenchymal cell proliferation; mesenchymal cell proliferation involved in lung development; mesenchymal stem cell differentiation; metanephros morphogenesis; midbrain development; midbrain dopaminergic neuron differentiation; morphogenesis of embryonic epithelium; myoblast proliferation; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron death; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; nephron tubule formation; nervous system development; neural plate development; neuroblast proliferation; neuron differentiation; neuron fate determination; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; oocyte development; osteoblast differentiation; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of branching involved in lung morphogenesis; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of molecular function; positive regulation of myoblast proliferation; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of stem cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of angiogenesis; regulation of apoptotic process; regulation of calcium ion import; regulation of cell differentiation; regulation of cell population proliferation; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of core promoter binding; regulation of epithelial cell differentiation; regulation of fibroblast proliferation; regulation of gene expression; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of synapse assembly; regulation of T cell proliferation; regulation of timing of anagen; regulation of transcription by RNA polymerase II; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to estradiol; response to xenobiotic stimulus; skeletal system development; skin development; smooth muscle cell differentiation; stem cell population maintenance; stem cell proliferation; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation; T cell differentiation in thymus; thymus development; tissue homeostasis; trachea formation; trachea morphogenesis; transcription by RNA polymerase II; vasculature development; vasculogenesis; Wnt signaling pathway","alpha-catenin binding; beta-catenin binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor binding; enzyme binding; histone methyltransferase binding; I-SMAD binding; kinase binding; nuclear estrogen receptor binding; nuclear receptor binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription coactivator activity; transcription coregulator binding; transcription corepressor binding; transmembrane transporter binding","adherens junction; anchoring junction; apical junction complex; apical part of cell; apicolateral plasma membrane; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-ICAT complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell projection; cell projection membrane; cell-cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; euchromatin; extracellular exosome; fascia adherens; flotillin complex; focal adhesion; glutamatergic synapse; intercalated disc; lamellipodium; lateral plasma membrane; membrane; microtubule organizing center; microvillus membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; RNA polymerase II transcription regulator complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription regulator complex; Wnt signalosome; Z disc","Wnt signaling","catenin beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=1499","1499","12387","84353",null,null,null,"P35222","Q02248","A0A0G2JT93","A0A8I3NUM7","A0A287AJ73","A0A5F7ZEY4","GO:0005912; GO:0070161; GO:0043296; GO:0045177; GO:0016327; GO:0016323; GO:0030877; GO:1990711; GO:1990907; GO:0070369; GO:0005923; GO:0016342; GO:0005938; GO:0030054; GO:0071944; GO:0042995; GO:0031253; GO:0005911; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0000791; GO:0070062; GO:0005916; GO:0016600; GO:0005925; GO:0098978; GO:0014704; GO:0030027; GO:0016328; GO:0016020; GO:0005815; GO:0031528; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0099092; GO:0045211; GO:0098831; GO:0042734; GO:0032991; GO:0032993; GO:0090575; GO:0098685; GO:0034750; GO:0000922; GO:0045202; GO:0005667; GO:1990909; GO:0030018","GO:0045294; GO:0008013; GO:0045296; GO:0003682; GO:0097718; GO:0140297; GO:0019899; GO:1990226; GO:0070411; GO:0019900; GO:0030331; GO:0016922; GO:0005515; GO:0008022; GO:0019901; GO:0019903; GO:0061629; GO:0046332; GO:0003713; GO:0001221; GO:0001222; GO:0044325","GO:0090425; GO:0034333; GO:0034332; GO:0048513; GO:0009948; GO:0097190; GO:0036520; GO:0045453; GO:0001569; GO:0001658; GO:0060070; GO:0044338; GO:1904954; GO:0044336; GO:0044339; GO:0061324; GO:0044334; GO:0007155; GO:0030154; GO:0001708; GO:0048469; GO:0000904; GO:0008283; GO:0098609; GO:0007160; GO:0071363; GO:0071681; GO:0022009; GO:0007268; GO:0002062; GO:0061550; GO:1904888; GO:0035995; GO:0006351; GO:1990791; GO:0009950; GO:0009953; GO:0007398; GO:0000578; GO:1990403; GO:0042733; GO:0048617; GO:0035115; GO:0035050; GO:0035116; GO:0048568; GO:0036023; GO:0001706; GO:0001711; GO:0061154; GO:0060742; GO:0060767; GO:0001837; GO:0060441; GO:0008543; GO:0030900; GO:0061198; GO:0001702; GO:0035112; GO:0002067; GO:0007403; GO:0035315; GO:0022405; GO:0031069; GO:0060789; GO:0007507; GO:0030097; GO:0030902; GO:0021854; GO:0007249; GO:0001701; GO:0001822; GO:0021819; GO:0002089; GO:0060173; GO:0060479; GO:0030324; GO:0060487; GO:0060492; GO:0060484; GO:0030539; GO:0000165; GO:0010463; GO:0060916; GO:0072497; GO:0003338; GO:0030901; GO:1904948; GO:0016331; GO:0051450; GO:0016525; GO:0043066; GO:2001234; GO:0090090; GO:0045596; GO:0008285; GO:0032331; GO:0045892; GO:0010629; GO:0003340; GO:0045976; GO:0050768; GO:1901215; GO:0048715; GO:0045671; GO:1903204; GO:0033234; GO:0000122; GO:0072079; GO:0007399; GO:0001840; GO:0007405; GO:0030182; GO:0048664; GO:0001764; GO:1990138; GO:0042475; GO:0048709; GO:0048599; GO:0001649; GO:0030316; GO:0060066; GO:0031016; GO:0043065; GO:0061047; GO:0045597; GO:0008284; GO:1904798; GO:2000017; GO:0051091; GO:0045893; GO:0045603; GO:0030858; GO:0060769; GO:0010718; GO:0045743; GO:0010628; GO:0010909; GO:0051571; GO:0043123; GO:0043410; GO:0002053; GO:0044093; GO:2000288; GO:2000179; GO:0002052; GO:0043525; GO:0045669; GO:0048643; GO:2000648; GO:0051973; GO:0032212; GO:0045944; GO:0032968; GO:0043161; GO:0008104; GO:0034394; GO:0000209; GO:0009954; GO:0045765; GO:0042981; GO:0090279; GO:0045595; GO:0042127; GO:0030997; GO:0070602; GO:1904796; GO:0030856; GO:0048145; GO:0010468; GO:0031641; GO:0072182; GO:0050767; GO:0045667; GO:0045670; GO:2000008; GO:0003266; GO:0048660; GO:0051963; GO:0042129; GO:0051884; GO:0006357; GO:0072053; GO:0072054; GO:0072033; GO:0032355; GO:0009410; GO:0001501; GO:0043588; GO:0051145; GO:0019827; GO:0072089; GO:0061549; GO:0050808; GO:0097091; GO:0048489; GO:0030217; GO:0033077; GO:0048538; GO:0001894; GO:0060440; GO:0060439; GO:0006366; GO:0001944; GO:0001570; GO:0016055","PTHR45976:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2514|UniProtKB=P35222","P06959; P06664; P00004; P00012; P00005; P04398; P00057"]
["beta-Catenin - phospho","Ser552","CTNNB1","92","rb",null,1,2,1,2,1,1,"# 1862",".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Angiogenesis; p53 pathway feedback loops 2; Wnt signaling pathway","CATENIN BETA-1","acinar cell differentiation; adherens junction assembly; adherens junction organization; animal organ development; anterior/posterior axis specification; apoptotic signaling pathway; astrocyte-dopaminergic neuron signaling; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in osteoblast differentiation; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell differentiation; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell population proliferation; cell-cell adhesion; cell-matrix adhesion; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chemical synaptic transmission; chondrocyte differentiation; cranial ganglion development; cranial skeletal system development; detection of muscle stretch; DNA-templated transcription; dorsal root ganglion development; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic organ development; embryonic skeletal limb joint morphogenesis; endoderm formation; endodermal cell fate commitment; endothelial tube morphogenesis; epithelial cell differentiation involved in prostate gland development; epithelial cell proliferation involved in prostate gland development; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain development; fungiform papilla formation; gastrulation with mouth forming second; genitalia morphogenesis; glandular epithelial cell differentiation; glial cell fate determination; hair cell differentiation; hair cycle process; hair follicle morphogenesis; hair follicle placode formation; heart development; hemopoiesis; hindbrain development; hypothalamus development; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; kidney development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; limb development; lung cell differentiation; lung development; lung epithelial cell differentiation; lung induction; lung-associated mesenchyme development; male genitalia development; MAPK cascade; mesenchymal cell proliferation; mesenchymal cell proliferation involved in lung development; mesenchymal stem cell differentiation; metanephros morphogenesis; midbrain development; midbrain dopaminergic neuron differentiation; morphogenesis of embryonic epithelium; myoblast proliferation; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron death; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; nephron tubule formation; nervous system development; neural plate development; neuroblast proliferation; neuron differentiation; neuron fate determination; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; oocyte development; osteoblast differentiation; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of branching involved in lung morphogenesis; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of molecular function; positive regulation of myoblast proliferation; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of stem cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of angiogenesis; regulation of apoptotic process; regulation of calcium ion import; regulation of cell differentiation; regulation of cell population proliferation; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of core promoter binding; regulation of epithelial cell differentiation; regulation of fibroblast proliferation; regulation of gene expression; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of synapse assembly; regulation of T cell proliferation; regulation of timing of anagen; regulation of transcription by RNA polymerase II; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to estradiol; response to xenobiotic stimulus; skeletal system development; skin development; smooth muscle cell differentiation; stem cell population maintenance; stem cell proliferation; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation; T cell differentiation in thymus; thymus development; tissue homeostasis; trachea formation; trachea morphogenesis; transcription by RNA polymerase II; vasculature development; vasculogenesis; Wnt signaling pathway","alpha-catenin binding; beta-catenin binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor binding; enzyme binding; histone methyltransferase binding; I-SMAD binding; kinase binding; nuclear estrogen receptor binding; nuclear receptor binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription coactivator activity; transcription coregulator binding; transcription corepressor binding; transmembrane transporter binding","adherens junction; anchoring junction; apical junction complex; apical part of cell; apicolateral plasma membrane; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-ICAT complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell projection; cell projection membrane; cell-cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; euchromatin; extracellular exosome; fascia adherens; flotillin complex; focal adhesion; glutamatergic synapse; intercalated disc; lamellipodium; lateral plasma membrane; membrane; microtubule organizing center; microvillus membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; RNA polymerase II transcription regulator complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription regulator complex; Wnt signalosome; Z disc",null,"catenin beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=1499","1499","12387","84353",null,null,null,"P35222","Q02248","A0A0G2JT93","A0A8I3NUM7","A0A287AJ73","A0A5F7ZEY4","GO:0005912; GO:0070161; GO:0043296; GO:0045177; GO:0016327; GO:0016323; GO:0030877; GO:1990711; GO:1990907; GO:0070369; GO:0005923; GO:0016342; GO:0005938; GO:0030054; GO:0071944; GO:0042995; GO:0031253; GO:0005911; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0000791; GO:0070062; GO:0005916; GO:0016600; GO:0005925; GO:0098978; GO:0014704; GO:0030027; GO:0016328; GO:0016020; GO:0005815; GO:0031528; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0099092; GO:0045211; GO:0098831; GO:0042734; GO:0032991; GO:0032993; GO:0090575; GO:0098685; GO:0034750; GO:0000922; GO:0045202; GO:0005667; GO:1990909; GO:0030018","GO:0045294; GO:0008013; GO:0045296; GO:0003682; GO:0097718; GO:0140297; GO:0019899; GO:1990226; GO:0070411; GO:0019900; GO:0030331; GO:0016922; GO:0005515; GO:0008022; GO:0019901; GO:0019903; GO:0061629; GO:0046332; GO:0003713; GO:0001221; GO:0001222; GO:0044325","GO:0090425; GO:0034333; GO:0034332; GO:0048513; GO:0009948; GO:0097190; GO:0036520; GO:0045453; GO:0001569; GO:0001658; GO:0060070; GO:0044338; GO:1904954; GO:0044336; GO:0044339; GO:0061324; GO:0044334; GO:0007155; GO:0030154; GO:0001708; GO:0048469; GO:0000904; GO:0008283; GO:0098609; GO:0007160; GO:0071363; GO:0071681; GO:0022009; GO:0007268; GO:0002062; GO:0061550; GO:1904888; GO:0035995; GO:0006351; GO:1990791; GO:0009950; GO:0009953; GO:0007398; GO:0000578; GO:1990403; GO:0042733; GO:0048617; GO:0035115; GO:0035050; GO:0035116; GO:0048568; GO:0036023; GO:0001706; GO:0001711; GO:0061154; GO:0060742; GO:0060767; GO:0001837; GO:0060441; GO:0008543; GO:0030900; GO:0061198; GO:0001702; GO:0035112; GO:0002067; GO:0007403; GO:0035315; GO:0022405; GO:0031069; GO:0060789; GO:0007507; GO:0030097; GO:0030902; GO:0021854; GO:0007249; GO:0001701; GO:0001822; GO:0021819; GO:0002089; GO:0060173; GO:0060479; GO:0030324; GO:0060487; GO:0060492; GO:0060484; GO:0030539; GO:0000165; GO:0010463; GO:0060916; GO:0072497; GO:0003338; GO:0030901; GO:1904948; GO:0016331; GO:0051450; GO:0016525; GO:0043066; GO:2001234; GO:0090090; GO:0045596; GO:0008285; GO:0032331; GO:0045892; GO:0010629; GO:0003340; GO:0045976; GO:0050768; GO:1901215; GO:0048715; GO:0045671; GO:1903204; GO:0033234; GO:0000122; GO:0072079; GO:0007399; GO:0001840; GO:0007405; GO:0030182; GO:0048664; GO:0001764; GO:1990138; GO:0042475; GO:0048709; GO:0048599; GO:0001649; GO:0030316; GO:0060066; GO:0031016; GO:0043065; GO:0061047; GO:0045597; GO:0008284; GO:1904798; GO:2000017; GO:0051091; GO:0045893; GO:0045603; GO:0030858; GO:0060769; GO:0010718; GO:0045743; GO:0010628; GO:0010909; GO:0051571; GO:0043123; GO:0043410; GO:0002053; GO:0044093; GO:2000288; GO:2000179; GO:0002052; GO:0043525; GO:0045669; GO:0048643; GO:2000648; GO:0051973; GO:0032212; GO:0045944; GO:0032968; GO:0043161; GO:0008104; GO:0034394; GO:0000209; GO:0009954; GO:0045765; GO:0042981; GO:0090279; GO:0045595; GO:0042127; GO:0030997; GO:0070602; GO:1904796; GO:0030856; GO:0048145; GO:0010468; GO:0031641; GO:0072182; GO:0050767; GO:0045667; GO:0045670; GO:2000008; GO:0003266; GO:0048660; GO:0051963; GO:0042129; GO:0051884; GO:0006357; GO:0072053; GO:0072054; GO:0072033; GO:0032355; GO:0009410; GO:0001501; GO:0043588; GO:0051145; GO:0019827; GO:0072089; GO:0061549; GO:0050808; GO:0097091; GO:0048489; GO:0030217; GO:0033077; GO:0048538; GO:0001894; GO:0060440; GO:0060439; GO:0006366; GO:0001944; GO:0001570; GO:0016055","PTHR45976:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2514|UniProtKB=P35222","P06959; P06664; P00004; P00012; P00005; P04398; P00057"]
["beta-Catenin - phospho","Ser675","CTNNB1","92","rb",null,1,1,2,2,2,2,"# 2091",".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Angiogenesis; p53 pathway feedback loops 2; Wnt signaling pathway","CATENIN BETA-1","acinar cell differentiation; adherens junction assembly; adherens junction organization; animal organ development; anterior/posterior axis specification; apoptotic signaling pathway; astrocyte-dopaminergic neuron signaling; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in osteoblast differentiation; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell differentiation; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell population proliferation; cell-cell adhesion; cell-matrix adhesion; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chemical synaptic transmission; chondrocyte differentiation; cranial ganglion development; cranial skeletal system development; detection of muscle stretch; DNA-templated transcription; dorsal root ganglion development; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic organ development; embryonic skeletal limb joint morphogenesis; endoderm formation; endodermal cell fate commitment; endothelial tube morphogenesis; epithelial cell differentiation involved in prostate gland development; epithelial cell proliferation involved in prostate gland development; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain development; fungiform papilla formation; gastrulation with mouth forming second; genitalia morphogenesis; glandular epithelial cell differentiation; glial cell fate determination; hair cell differentiation; hair cycle process; hair follicle morphogenesis; hair follicle placode formation; heart development; hemopoiesis; hindbrain development; hypothalamus development; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; kidney development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; limb development; lung cell differentiation; lung development; lung epithelial cell differentiation; lung induction; lung-associated mesenchyme development; male genitalia development; MAPK cascade; mesenchymal cell proliferation; mesenchymal cell proliferation involved in lung development; mesenchymal stem cell differentiation; metanephros morphogenesis; midbrain development; midbrain dopaminergic neuron differentiation; morphogenesis of embryonic epithelium; myoblast proliferation; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron death; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; nephron tubule formation; nervous system development; neural plate development; neuroblast proliferation; neuron differentiation; neuron fate determination; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; oocyte development; osteoblast differentiation; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of branching involved in lung morphogenesis; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of molecular function; positive regulation of myoblast proliferation; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of stem cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of angiogenesis; regulation of apoptotic process; regulation of calcium ion import; regulation of cell differentiation; regulation of cell population proliferation; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of core promoter binding; regulation of epithelial cell differentiation; regulation of fibroblast proliferation; regulation of gene expression; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of synapse assembly; regulation of T cell proliferation; regulation of timing of anagen; regulation of transcription by RNA polymerase II; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to estradiol; response to xenobiotic stimulus; skeletal system development; skin development; smooth muscle cell differentiation; stem cell population maintenance; stem cell proliferation; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation; T cell differentiation in thymus; thymus development; tissue homeostasis; trachea formation; trachea morphogenesis; transcription by RNA polymerase II; vasculature development; vasculogenesis; Wnt signaling pathway","alpha-catenin binding; beta-catenin binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor binding; enzyme binding; histone methyltransferase binding; I-SMAD binding; kinase binding; nuclear estrogen receptor binding; nuclear receptor binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription coactivator activity; transcription coregulator binding; transcription corepressor binding; transmembrane transporter binding","adherens junction; anchoring junction; apical junction complex; apical part of cell; apicolateral plasma membrane; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-ICAT complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell projection; cell projection membrane; cell-cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; euchromatin; extracellular exosome; fascia adherens; flotillin complex; focal adhesion; glutamatergic synapse; intercalated disc; lamellipodium; lateral plasma membrane; membrane; microtubule organizing center; microvillus membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; RNA polymerase II transcription regulator complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription regulator complex; Wnt signalosome; Z disc","Wnt signaling","catenin beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=1499","1499","12387","84353",null,null,null,"P35222","Q02248","A0A0G2JT93","A0A8I3NUM7","A0A287AJ73","A0A5F7ZEY4","GO:0005912; GO:0070161; GO:0043296; GO:0045177; GO:0016327; GO:0016323; GO:0030877; GO:1990711; GO:1990907; GO:0070369; GO:0005923; GO:0016342; GO:0005938; GO:0030054; GO:0071944; GO:0042995; GO:0031253; GO:0005911; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0000791; GO:0070062; GO:0005916; GO:0016600; GO:0005925; GO:0098978; GO:0014704; GO:0030027; GO:0016328; GO:0016020; GO:0005815; GO:0031528; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0099092; GO:0045211; GO:0098831; GO:0042734; GO:0032991; GO:0032993; GO:0090575; GO:0098685; GO:0034750; GO:0000922; GO:0045202; GO:0005667; GO:1990909; GO:0030018","GO:0045294; GO:0008013; GO:0045296; GO:0003682; GO:0097718; GO:0140297; GO:0019899; GO:1990226; GO:0070411; GO:0019900; GO:0030331; GO:0016922; GO:0005515; GO:0008022; GO:0019901; GO:0019903; GO:0061629; GO:0046332; GO:0003713; GO:0001221; GO:0001222; GO:0044325","GO:0090425; GO:0034333; GO:0034332; GO:0048513; GO:0009948; GO:0097190; GO:0036520; GO:0045453; GO:0001569; GO:0001658; GO:0060070; GO:0044338; GO:1904954; GO:0044336; GO:0044339; GO:0061324; GO:0044334; GO:0007155; GO:0030154; GO:0001708; GO:0048469; GO:0000904; GO:0008283; GO:0098609; GO:0007160; GO:0071363; GO:0071681; GO:0022009; GO:0007268; GO:0002062; GO:0061550; GO:1904888; GO:0035995; GO:0006351; GO:1990791; GO:0009950; GO:0009953; GO:0007398; GO:0000578; GO:1990403; GO:0042733; GO:0048617; GO:0035115; GO:0035050; GO:0035116; GO:0048568; GO:0036023; GO:0001706; GO:0001711; GO:0061154; GO:0060742; GO:0060767; GO:0001837; GO:0060441; GO:0008543; GO:0030900; GO:0061198; GO:0001702; GO:0035112; GO:0002067; GO:0007403; GO:0035315; GO:0022405; GO:0031069; GO:0060789; GO:0007507; GO:0030097; GO:0030902; GO:0021854; GO:0007249; GO:0001701; GO:0001822; GO:0021819; GO:0002089; GO:0060173; GO:0060479; GO:0030324; GO:0060487; GO:0060492; GO:0060484; GO:0030539; GO:0000165; GO:0010463; GO:0060916; GO:0072497; GO:0003338; GO:0030901; GO:1904948; GO:0016331; GO:0051450; GO:0016525; GO:0043066; GO:2001234; GO:0090090; GO:0045596; GO:0008285; GO:0032331; GO:0045892; GO:0010629; GO:0003340; GO:0045976; GO:0050768; GO:1901215; GO:0048715; GO:0045671; GO:1903204; GO:0033234; GO:0000122; GO:0072079; GO:0007399; GO:0001840; GO:0007405; GO:0030182; GO:0048664; GO:0001764; GO:1990138; GO:0042475; GO:0048709; GO:0048599; GO:0001649; GO:0030316; GO:0060066; GO:0031016; GO:0043065; GO:0061047; GO:0045597; GO:0008284; GO:1904798; GO:2000017; GO:0051091; GO:0045893; GO:0045603; GO:0030858; GO:0060769; GO:0010718; GO:0045743; GO:0010628; GO:0010909; GO:0051571; GO:0043123; GO:0043410; GO:0002053; GO:0044093; GO:2000288; GO:2000179; GO:0002052; GO:0043525; GO:0045669; GO:0048643; GO:2000648; GO:0051973; GO:0032212; GO:0045944; GO:0032968; GO:0043161; GO:0008104; GO:0034394; GO:0000209; GO:0009954; GO:0045765; GO:0042981; GO:0090279; GO:0045595; GO:0042127; GO:0030997; GO:0070602; GO:1904796; GO:0030856; GO:0048145; GO:0010468; GO:0031641; GO:0072182; GO:0050767; GO:0045667; GO:0045670; GO:2000008; GO:0003266; GO:0048660; GO:0051963; GO:0042129; GO:0051884; GO:0006357; GO:0072053; GO:0072054; GO:0072033; GO:0032355; GO:0009410; GO:0001501; GO:0043588; GO:0051145; GO:0019827; GO:0072089; GO:0061549; GO:0050808; GO:0097091; GO:0048489; GO:0030217; GO:0033077; GO:0048538; GO:0001894; GO:0060440; GO:0060439; GO:0006366; GO:0001944; GO:0001570; GO:0016055","PTHR45976:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2514|UniProtKB=P35222","P06959; P06664; P00004; P00012; P00005; P04398; P00057"]
["beta-Catenin - phospho","Thr41/Ser45","CTNNB1","92","rb",null,2.1,4,4,4,1.1000000000000001,1.1000000000000001,"BG/MP # 091",".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Angiogenesis; p53 pathway feedback loops 2; Wnt signaling pathway","CATENIN BETA-1","acinar cell differentiation; adherens junction assembly; adherens junction organization; animal organ development; anterior/posterior axis specification; apoptotic signaling pathway; astrocyte-dopaminergic neuron signaling; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in osteoblast differentiation; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell differentiation; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell population proliferation; cell-cell adhesion; cell-matrix adhesion; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chemical synaptic transmission; chondrocyte differentiation; cranial ganglion development; cranial skeletal system development; detection of muscle stretch; DNA-templated transcription; dorsal root ganglion development; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic organ development; embryonic skeletal limb joint morphogenesis; endoderm formation; endodermal cell fate commitment; endothelial tube morphogenesis; epithelial cell differentiation involved in prostate gland development; epithelial cell proliferation involved in prostate gland development; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain development; fungiform papilla formation; gastrulation with mouth forming second; genitalia morphogenesis; glandular epithelial cell differentiation; glial cell fate determination; hair cell differentiation; hair cycle process; hair follicle morphogenesis; hair follicle placode formation; heart development; hemopoiesis; hindbrain development; hypothalamus development; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; kidney development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; limb development; lung cell differentiation; lung development; lung epithelial cell differentiation; lung induction; lung-associated mesenchyme development; male genitalia development; MAPK cascade; mesenchymal cell proliferation; mesenchymal cell proliferation involved in lung development; mesenchymal stem cell differentiation; metanephros morphogenesis; midbrain development; midbrain dopaminergic neuron differentiation; morphogenesis of embryonic epithelium; myoblast proliferation; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron death; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; nephron tubule formation; nervous system development; neural plate development; neuroblast proliferation; neuron differentiation; neuron fate determination; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; oocyte development; osteoblast differentiation; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of branching involved in lung morphogenesis; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of molecular function; positive regulation of myoblast proliferation; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of stem cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of angiogenesis; regulation of apoptotic process; regulation of calcium ion import; regulation of cell differentiation; regulation of cell population proliferation; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of core promoter binding; regulation of epithelial cell differentiation; regulation of fibroblast proliferation; regulation of gene expression; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of synapse assembly; regulation of T cell proliferation; regulation of timing of anagen; regulation of transcription by RNA polymerase II; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to estradiol; response to xenobiotic stimulus; skeletal system development; skin development; smooth muscle cell differentiation; stem cell population maintenance; stem cell proliferation; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation; T cell differentiation in thymus; thymus development; tissue homeostasis; trachea formation; trachea morphogenesis; transcription by RNA polymerase II; vasculature development; vasculogenesis; Wnt signaling pathway","alpha-catenin binding; beta-catenin binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor binding; enzyme binding; histone methyltransferase binding; I-SMAD binding; kinase binding; nuclear estrogen receptor binding; nuclear receptor binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription coactivator activity; transcription coregulator binding; transcription corepressor binding; transmembrane transporter binding","adherens junction; anchoring junction; apical junction complex; apical part of cell; apicolateral plasma membrane; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-ICAT complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell projection; cell projection membrane; cell-cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; euchromatin; extracellular exosome; fascia adherens; flotillin complex; focal adhesion; glutamatergic synapse; intercalated disc; lamellipodium; lateral plasma membrane; membrane; microtubule organizing center; microvillus membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; RNA polymerase II transcription regulator complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription regulator complex; Wnt signalosome; Z disc","Wnt signaling","catenin beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=1499","1499","12387","84353",null,null,null,"P35222","Q02248","A0A0G2JT93","A0A8I3NUM7","A0A287AJ73","A0A5F7ZEY4","GO:0005912; GO:0070161; GO:0043296; GO:0045177; GO:0016327; GO:0016323; GO:0030877; GO:1990711; GO:1990907; GO:0070369; GO:0005923; GO:0016342; GO:0005938; GO:0030054; GO:0071944; GO:0042995; GO:0031253; GO:0005911; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0000791; GO:0070062; GO:0005916; GO:0016600; GO:0005925; GO:0098978; GO:0014704; GO:0030027; GO:0016328; GO:0016020; GO:0005815; GO:0031528; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0099092; GO:0045211; GO:0098831; GO:0042734; GO:0032991; GO:0032993; GO:0090575; GO:0098685; GO:0034750; GO:0000922; GO:0045202; GO:0005667; GO:1990909; GO:0030018","GO:0045294; GO:0008013; GO:0045296; GO:0003682; GO:0097718; GO:0140297; GO:0019899; GO:1990226; GO:0070411; GO:0019900; GO:0030331; GO:0016922; GO:0005515; GO:0008022; GO:0019901; GO:0019903; GO:0061629; GO:0046332; GO:0003713; GO:0001221; GO:0001222; GO:0044325","GO:0090425; GO:0034333; GO:0034332; GO:0048513; GO:0009948; GO:0097190; GO:0036520; GO:0045453; GO:0001569; GO:0001658; GO:0060070; GO:0044338; GO:1904954; GO:0044336; GO:0044339; GO:0061324; GO:0044334; GO:0007155; GO:0030154; GO:0001708; GO:0048469; GO:0000904; GO:0008283; GO:0098609; GO:0007160; GO:0071363; GO:0071681; GO:0022009; GO:0007268; GO:0002062; GO:0061550; GO:1904888; GO:0035995; GO:0006351; GO:1990791; GO:0009950; GO:0009953; GO:0007398; GO:0000578; GO:1990403; GO:0042733; GO:0048617; GO:0035115; GO:0035050; GO:0035116; GO:0048568; GO:0036023; GO:0001706; GO:0001711; GO:0061154; GO:0060742; GO:0060767; GO:0001837; GO:0060441; GO:0008543; GO:0030900; GO:0061198; GO:0001702; GO:0035112; GO:0002067; GO:0007403; GO:0035315; GO:0022405; GO:0031069; GO:0060789; GO:0007507; GO:0030097; GO:0030902; GO:0021854; GO:0007249; GO:0001701; GO:0001822; GO:0021819; GO:0002089; GO:0060173; GO:0060479; GO:0030324; GO:0060487; GO:0060492; GO:0060484; GO:0030539; GO:0000165; GO:0010463; GO:0060916; GO:0072497; GO:0003338; GO:0030901; GO:1904948; GO:0016331; GO:0051450; GO:0016525; GO:0043066; GO:2001234; GO:0090090; GO:0045596; GO:0008285; GO:0032331; GO:0045892; GO:0010629; GO:0003340; GO:0045976; GO:0050768; GO:1901215; GO:0048715; GO:0045671; GO:1903204; GO:0033234; GO:0000122; GO:0072079; GO:0007399; GO:0001840; GO:0007405; GO:0030182; GO:0048664; GO:0001764; GO:1990138; GO:0042475; GO:0048709; GO:0048599; GO:0001649; GO:0030316; GO:0060066; GO:0031016; GO:0043065; GO:0061047; GO:0045597; GO:0008284; GO:1904798; GO:2000017; GO:0051091; GO:0045893; GO:0045603; GO:0030858; GO:0060769; GO:0010718; GO:0045743; GO:0010628; GO:0010909; GO:0051571; GO:0043123; GO:0043410; GO:0002053; GO:0044093; GO:2000288; GO:2000179; GO:0002052; GO:0043525; GO:0045669; GO:0048643; GO:2000648; GO:0051973; GO:0032212; GO:0045944; GO:0032968; GO:0043161; GO:0008104; GO:0034394; GO:0000209; GO:0009954; GO:0045765; GO:0042981; GO:0090279; GO:0045595; GO:0042127; GO:0030997; GO:0070602; GO:1904796; GO:0030856; GO:0048145; GO:0010468; GO:0031641; GO:0072182; GO:0050767; GO:0045667; GO:0045670; GO:2000008; GO:0003266; GO:0048660; GO:0051963; GO:0042129; GO:0051884; GO:0006357; GO:0072053; GO:0072054; GO:0072033; GO:0032355; GO:0009410; GO:0001501; GO:0043588; GO:0051145; GO:0019827; GO:0072089; GO:0061549; GO:0050808; GO:0097091; GO:0048489; GO:0030217; GO:0033077; GO:0048538; GO:0001894; GO:0060440; GO:0060439; GO:0006366; GO:0001944; GO:0001570; GO:0016055","PTHR45976:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2514|UniProtKB=P35222","P06959; P06664; P00004; P00012; P00005; P04398; P00057"]
["beta-Catenin (non-phospho Ser33/37/Thr41; active)",null,"CTNNB1","92","rb",null,2,1,1,8,2,1,"# 2323",".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Angiogenesis; p53 pathway feedback loops 2; Wnt signaling pathway","CATENIN BETA-1","acinar cell differentiation; adherens junction assembly; adherens junction organization; animal organ development; anterior/posterior axis specification; apoptotic signaling pathway; astrocyte-dopaminergic neuron signaling; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in osteoblast differentiation; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell differentiation; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell population proliferation; cell-cell adhesion; cell-matrix adhesion; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chemical synaptic transmission; chondrocyte differentiation; cranial ganglion development; cranial skeletal system development; detection of muscle stretch; DNA-templated transcription; dorsal root ganglion development; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic organ development; embryonic skeletal limb joint morphogenesis; endoderm formation; endodermal cell fate commitment; endothelial tube morphogenesis; epithelial cell differentiation involved in prostate gland development; epithelial cell proliferation involved in prostate gland development; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain development; fungiform papilla formation; gastrulation with mouth forming second; genitalia morphogenesis; glandular epithelial cell differentiation; glial cell fate determination; hair cell differentiation; hair cycle process; hair follicle morphogenesis; hair follicle placode formation; heart development; hemopoiesis; hindbrain development; hypothalamus development; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; kidney development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; limb development; lung cell differentiation; lung development; lung epithelial cell differentiation; lung induction; lung-associated mesenchyme development; male genitalia development; MAPK cascade; mesenchymal cell proliferation; mesenchymal cell proliferation involved in lung development; mesenchymal stem cell differentiation; metanephros morphogenesis; midbrain development; midbrain dopaminergic neuron differentiation; morphogenesis of embryonic epithelium; myoblast proliferation; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron death; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; nephron tubule formation; nervous system development; neural plate development; neuroblast proliferation; neuron differentiation; neuron fate determination; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; oocyte development; osteoblast differentiation; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of branching involved in lung morphogenesis; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of molecular function; positive regulation of myoblast proliferation; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of stem cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of angiogenesis; regulation of apoptotic process; regulation of calcium ion import; regulation of cell differentiation; regulation of cell population proliferation; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of core promoter binding; regulation of epithelial cell differentiation; regulation of fibroblast proliferation; regulation of gene expression; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of synapse assembly; regulation of T cell proliferation; regulation of timing of anagen; regulation of transcription by RNA polymerase II; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to estradiol; response to xenobiotic stimulus; skeletal system development; skin development; smooth muscle cell differentiation; stem cell population maintenance; stem cell proliferation; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation; T cell differentiation in thymus; thymus development; tissue homeostasis; trachea formation; trachea morphogenesis; transcription by RNA polymerase II; vasculature development; vasculogenesis; Wnt signaling pathway","alpha-catenin binding; beta-catenin binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor binding; enzyme binding; histone methyltransferase binding; I-SMAD binding; kinase binding; nuclear estrogen receptor binding; nuclear receptor binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription coactivator activity; transcription coregulator binding; transcription corepressor binding; transmembrane transporter binding","adherens junction; anchoring junction; apical junction complex; apical part of cell; apicolateral plasma membrane; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-ICAT complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell projection; cell projection membrane; cell-cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; euchromatin; extracellular exosome; fascia adherens; flotillin complex; focal adhesion; glutamatergic synapse; intercalated disc; lamellipodium; lateral plasma membrane; membrane; microtubule organizing center; microvillus membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; RNA polymerase II transcription regulator complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription regulator complex; Wnt signalosome; Z disc","Wnt signaling","catenin beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=1499","1499","12387","84353",null,null,null,"P35222","Q02248","A0A0G2JT93","A0A8I3NUM7","A0A287AJ73","A0A5F7ZEY4","GO:0005912; GO:0070161; GO:0043296; GO:0045177; GO:0016327; GO:0016323; GO:0030877; GO:1990711; GO:1990907; GO:0070369; GO:0005923; GO:0016342; GO:0005938; GO:0030054; GO:0071944; GO:0042995; GO:0031253; GO:0005911; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0000791; GO:0070062; GO:0005916; GO:0016600; GO:0005925; GO:0098978; GO:0014704; GO:0030027; GO:0016328; GO:0016020; GO:0005815; GO:0031528; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0099092; GO:0045211; GO:0098831; GO:0042734; GO:0032991; GO:0032993; GO:0090575; GO:0098685; GO:0034750; GO:0000922; GO:0045202; GO:0005667; GO:1990909; GO:0030018","GO:0045294; GO:0008013; GO:0045296; GO:0003682; GO:0097718; GO:0140297; GO:0019899; GO:1990226; GO:0070411; GO:0019900; GO:0030331; GO:0016922; GO:0005515; GO:0008022; GO:0019901; GO:0019903; GO:0061629; GO:0046332; GO:0003713; GO:0001221; GO:0001222; GO:0044325","GO:0090425; GO:0034333; GO:0034332; GO:0048513; GO:0009948; GO:0097190; GO:0036520; GO:0045453; GO:0001569; GO:0001658; GO:0060070; GO:0044338; GO:1904954; GO:0044336; GO:0044339; GO:0061324; GO:0044334; GO:0007155; GO:0030154; GO:0001708; GO:0048469; GO:0000904; GO:0008283; GO:0098609; GO:0007160; GO:0071363; GO:0071681; GO:0022009; GO:0007268; GO:0002062; GO:0061550; GO:1904888; GO:0035995; GO:0006351; GO:1990791; GO:0009950; GO:0009953; GO:0007398; GO:0000578; GO:1990403; GO:0042733; GO:0048617; GO:0035115; GO:0035050; GO:0035116; GO:0048568; GO:0036023; GO:0001706; GO:0001711; GO:0061154; GO:0060742; GO:0060767; GO:0001837; GO:0060441; GO:0008543; GO:0030900; GO:0061198; GO:0001702; GO:0035112; GO:0002067; GO:0007403; GO:0035315; GO:0022405; GO:0031069; GO:0060789; GO:0007507; GO:0030097; GO:0030902; GO:0021854; GO:0007249; GO:0001701; GO:0001822; GO:0021819; GO:0002089; GO:0060173; GO:0060479; GO:0030324; GO:0060487; GO:0060492; GO:0060484; GO:0030539; GO:0000165; GO:0010463; GO:0060916; GO:0072497; GO:0003338; GO:0030901; GO:1904948; GO:0016331; GO:0051450; GO:0016525; GO:0043066; GO:2001234; GO:0090090; GO:0045596; GO:0008285; GO:0032331; GO:0045892; GO:0010629; GO:0003340; GO:0045976; GO:0050768; GO:1901215; GO:0048715; GO:0045671; GO:1903204; GO:0033234; GO:0000122; GO:0072079; GO:0007399; GO:0001840; GO:0007405; GO:0030182; GO:0048664; GO:0001764; GO:1990138; GO:0042475; GO:0048709; GO:0048599; GO:0001649; GO:0030316; GO:0060066; GO:0031016; GO:0043065; GO:0061047; GO:0045597; GO:0008284; GO:1904798; GO:2000017; GO:0051091; GO:0045893; GO:0045603; GO:0030858; GO:0060769; GO:0010718; GO:0045743; GO:0010628; GO:0010909; GO:0051571; GO:0043123; GO:0043410; GO:0002053; GO:0044093; GO:2000288; GO:2000179; GO:0002052; GO:0043525; GO:0045669; GO:0048643; GO:2000648; GO:0051973; GO:0032212; GO:0045944; GO:0032968; GO:0043161; GO:0008104; GO:0034394; GO:0000209; GO:0009954; GO:0045765; GO:0042981; GO:0090279; GO:0045595; GO:0042127; GO:0030997; GO:0070602; GO:1904796; GO:0030856; GO:0048145; GO:0010468; GO:0031641; GO:0072182; GO:0050767; GO:0045667; GO:0045670; GO:2000008; GO:0003266; GO:0048660; GO:0051963; GO:0042129; GO:0051884; GO:0006357; GO:0072053; GO:0072054; GO:0072033; GO:0032355; GO:0009410; GO:0001501; GO:0043588; GO:0051145; GO:0019827; GO:0072089; GO:0061549; GO:0050808; GO:0097091; GO:0048489; GO:0030217; GO:0033077; GO:0048538; GO:0001894; GO:0060440; GO:0060439; GO:0006366; GO:0001944; GO:0001570; GO:0016055","PTHR45976:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2514|UniProtKB=P35222","P06959; P06664; P00004; P00012; P00005; P04398; P00057"]
["BID",null,"BID","22","ms",null,2,4,3,7,4,4,"# 0675",".ALZ., .APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DI., .HEPB., .OP., .OPA., .P53S., .ST.",null,"BH3-INTERACTING DOMAIN DEATH AGONIST","activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic mitochondrial changes; apoptotic process; establishment of protein localization to membrane; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway via death domain receptors; hepatocyte apoptotic process; mitochondrial ATP synthesis coupled electron transport; mitochondrial outer membrane permeabilization; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; neuron apoptotic process; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of fibroblast apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial membrane potential; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; protein targeting to mitochondrion; protein-containing complex assembly; regulation of apoptotic process; regulation of apoptotic signaling pathway; regulation of epithelial cell proliferation; regulation of G1/S transition of mitotic cell cycle; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of T cell proliferation; release of cytochrome c from mitochondria; signal transduction in response to DNA damage; supramolecular fiber organization","death receptor binding; protein binding; ubiquitin protein ligase binding","cytoplasm; cytosol; membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion","Apoptosis","BH3 interacting domain death agonist","http://www.ncbi.nlm.nih.gov/gene/?term=637","637","12122","64625",null,"594852","100426724","P55957","P70444","Q9JLT6","A0A8I3Q5A3","Q4JHS0","A0A1D5QH89","GO:0005737; GO:0005829; GO:0016020; GO:0031966; GO:0005741; GO:0005739","GO:0005123; GO:0005515; GO:0031625","GO:0006919; GO:0008637; GO:0006915; GO:0090150; GO:0097191; GO:0008625; GO:0097284; GO:0042775; GO:0097345; GO:1902230; GO:0051402; GO:0043065; GO:2001235; GO:2001238; GO:2000271; GO:2001244; GO:0010918; GO:0031334; GO:0090200; GO:0006626; GO:0065003; GO:0042981; GO:2001233; GO:0050678; GO:2000045; GO:1902108; GO:0042129; GO:0001836; GO:0042770; GO:0097435","PTHR35447:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1050|UniProtKB=P55957"]
["Bik",null,"BIK","18","rb",null,3,3,3,3,3,3,"# 0718",".APO., .CD., .CSP.","Apoptosis signaling pathway","BCL-2-INTERACTING KILLER","apoptotic mitochondrial changes; apoptotic process; male gonad development; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; regulation of apoptotic process","protein binding","Bcl-2 family protein complex; endomembrane system; membrane; mitochondrial membrane; mitochondrion","Apoptosis","BCL2 interacting killer","http://www.ncbi.nlm.nih.gov/gene/?term=638","638","12124",null,null,null,null,"Q13323","O70337","A0A8I6GEH5",null,null,null,"GO:0097136; GO:0012505; GO:0016020; GO:0031966; GO:0005739","GO:0005515","GO:0008637; GO:0006915; GO:0008584; GO:0031334; GO:0090200; GO:0042981","PTHR15018:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1051|UniProtKB=Q13323","P00006"]
["Bik",null,"BIK","20","rb",null,3,3.1,"n/a","n/a","n/a","n/a","BG/MP # 083",".APO., .CD., .CSP.","Apoptosis signaling pathway","BCL-2-INTERACTING KILLER","apoptotic mitochondrial changes; apoptotic process; male gonad development; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; regulation of apoptotic process","protein binding","Bcl-2 family protein complex; endomembrane system; membrane; mitochondrial membrane; mitochondrion","Apoptosis","BCL2 interacting killer","http://www.ncbi.nlm.nih.gov/gene/?term=638","638","12124",null,null,null,null,"Q13323","O70337","A0A8I6GEH5",null,null,null,"GO:0097136; GO:0012505; GO:0016020; GO:0031966; GO:0005739","GO:0005515","GO:0008637; GO:0006915; GO:0008584; GO:0031334; GO:0090200; GO:0042981","PTHR15018:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1051|UniProtKB=Q13323","P00006"]
["Bik - phospho","Thr33","BIK","18","rb",null,2,4,"n/a","n/a","n/a","n/a","# 0732",".APO., .CD., .CSP.","Apoptosis signaling pathway","BCL-2-INTERACTING KILLER","apoptotic mitochondrial changes; apoptotic process; male gonad development; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; regulation of apoptotic process","protein binding","Bcl-2 family protein complex; endomembrane system; membrane; mitochondrial membrane; mitochondrion","Apoptosis","BCL2 interacting killer","http://www.ncbi.nlm.nih.gov/gene/?term=638","638","12124",null,null,null,null,"Q13323","O70337","A0A8I6GEH5",null,null,null,"GO:0097136; GO:0012505; GO:0016020; GO:0031966; GO:0005739","GO:0005515","GO:0008637; GO:0006915; GO:0008584; GO:0031334; GO:0090200; GO:0042981","PTHR15018:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1051|UniProtKB=Q13323","P00006"]
["Bim",null,"BCL2L11","23, 15, 12","rb",null,1,2.1,"n/a","n/a","n/a","n/a","# 0680",".APH., .APO., .BCR., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CRC., .CSP., .DDR., .EGFR., .FOXO., .IMUF., .OP., .OPA., .PI3K., .RTK., .ST., .TD., .TMAT.","Apoptosis signaling pathway","BCL-2-LIKE PROTEIN 11","apoptotic process; apoptotic process involved in embryonic digit morphogenesis; B cell homeostasis; brain development; cell-matrix adhesion; cellular response to amyloid-beta; cellular response to estradiol stimulus; cellular response to glucocorticoid stimulus; developmental pigmentation; ear development; extrinsic apoptotic signaling pathway in absence of ligand; in utero embryonic development; intrinsic apoptotic signaling pathway in response to DNA damage; kidney development; leukocyte homeostasis; lymphocyte apoptotic process; lymphocyte homeostasis; male gonad development; mammary gland development; meiosis I; myeloid cell homeostasis; odontogenesis of dentin-containing tooth; positive regulation of apoptotic process; positive regulation of autophagy in response to ER overload; positive regulation of cell cycle; positive regulation of cell death; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of fibroblast apoptotic process; positive regulation of IRE1-mediated unfolded protein response; positive regulation of lymphocyte apoptotic process; positive regulation of mitochondrial membrane permeability involved in apoptotic process; positive regulation of neuron apoptotic process; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; positive regulation of T cell apoptotic process; post-embryonic animal organ morphogenesis; post-embryonic development; regulation of apoptotic process; regulation of developmental pigmentation; regulation of organ growth; response to endoplasmic reticulum stress; spermatogenesis; spleen development; T cell apoptotic process; T cell homeostasis; thymocyte apoptotic process; thymus development; tube formation","microtubule binding; molecular adaptor activity; protein binding; protein kinase binding","Bcl-2 family protein complex; cytoplasm; cytosol; endomembrane system; intracellular membrane-bounded organelle; membrane; mitochondrial outer membrane; mitochondrion","Apoptosis","BCL2 like 11","http://www.ncbi.nlm.nih.gov/gene/?term=10018","10018","12125",null,null,null,"697082","O43521","O54918","A0A8I5ZK47","A0A8I3N6G2","A0A5G2QUY1","F7HHA1","GO:0097136; GO:0005737; GO:0005829; GO:0012505; GO:0043231; GO:0016020; GO:0005741; GO:0005739","GO:0008017; GO:0060090; GO:0005515; GO:0019901","GO:0006915; GO:1902263; GO:0001782; GO:0007420; GO:0007160; GO:1904646; GO:0071392; GO:0071385; GO:0048066; GO:0043583; GO:0097192; GO:0001701; GO:0008630; GO:0001822; GO:0001776; GO:0070227; GO:0002260; GO:0008584; GO:0030879; GO:0007127; GO:0002262; GO:0042475; GO:0043065; GO:0034263; GO:0045787; GO:0010942; GO:0043280; GO:1902237; GO:2000271; GO:1903896; GO:0070230; GO:1902110; GO:0043525; GO:0031334; GO:0090200; GO:0070234; GO:0048563; GO:0009791; GO:0042981; GO:0048070; GO:0046620; GO:0034976; GO:0007283; GO:0048536; GO:0070231; GO:0043029; GO:0070242; GO:0048538; GO:0035148","PTHR12044:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=994|UniProtKB=O43521","P00006"]
["Bim - phospho","Ser69","BCL2L11","26","rb",null,4,4,4,4,4,4,"# 0699",".APH., .APO., .BCR., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CRC., .CSP., .DDR., .EGFR., .FOXO., .IMUF., .OP., .OPA., .PI3K., .RTK., .ST., .TD., .TMAT.","Apoptosis signaling pathway","BCL-2-LIKE PROTEIN 11","apoptotic process; apoptotic process involved in embryonic digit morphogenesis; B cell homeostasis; brain development; cell-matrix adhesion; cellular response to amyloid-beta; cellular response to estradiol stimulus; cellular response to glucocorticoid stimulus; developmental pigmentation; ear development; extrinsic apoptotic signaling pathway in absence of ligand; in utero embryonic development; intrinsic apoptotic signaling pathway in response to DNA damage; kidney development; leukocyte homeostasis; lymphocyte apoptotic process; lymphocyte homeostasis; male gonad development; mammary gland development; meiosis I; myeloid cell homeostasis; odontogenesis of dentin-containing tooth; positive regulation of apoptotic process; positive regulation of autophagy in response to ER overload; positive regulation of cell cycle; positive regulation of cell death; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of fibroblast apoptotic process; positive regulation of IRE1-mediated unfolded protein response; positive regulation of lymphocyte apoptotic process; positive regulation of mitochondrial membrane permeability involved in apoptotic process; positive regulation of neuron apoptotic process; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; positive regulation of T cell apoptotic process; post-embryonic animal organ morphogenesis; post-embryonic development; regulation of apoptotic process; regulation of developmental pigmentation; regulation of organ growth; response to endoplasmic reticulum stress; spermatogenesis; spleen development; T cell apoptotic process; T cell homeostasis; thymocyte apoptotic process; thymus development; tube formation","microtubule binding; molecular adaptor activity; protein binding; protein kinase binding","Bcl-2 family protein complex; cytoplasm; cytosol; endomembrane system; intracellular membrane-bounded organelle; membrane; mitochondrial outer membrane; mitochondrion","Apoptosis","BCL2 like 11","http://www.ncbi.nlm.nih.gov/gene/?term=10018","10018","12125",null,null,null,"697082","O43521","O54918","A0A8I5ZK47","A0A8I3N6G2","A0A5G2QUY1","F7HHA1","GO:0097136; GO:0005737; GO:0005829; GO:0012505; GO:0043231; GO:0016020; GO:0005741; GO:0005739","GO:0008017; GO:0060090; GO:0005515; GO:0019901","GO:0006915; GO:1902263; GO:0001782; GO:0007420; GO:0007160; GO:1904646; GO:0071392; GO:0071385; GO:0048066; GO:0043583; GO:0097192; GO:0001701; GO:0008630; GO:0001822; GO:0001776; GO:0070227; GO:0002260; GO:0008584; GO:0030879; GO:0007127; GO:0002262; GO:0042475; GO:0043065; GO:0034263; GO:0045787; GO:0010942; GO:0043280; GO:1902237; GO:2000271; GO:1903896; GO:0070230; GO:1902110; GO:0043525; GO:0031334; GO:0090200; GO:0070234; GO:0048563; GO:0009791; GO:0042981; GO:0048070; GO:0046620; GO:0034976; GO:0007283; GO:0048536; GO:0070231; GO:0043029; GO:0070242; GO:0048538; GO:0035148","PTHR12044:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=994|UniProtKB=O43521","P00006"]
["Bip",null,"HSPA5","78","rb",null,1,2,2,2,2,2,"# 0425",".APO., .cAMP., .CD., .CSP., .DEV., .DI., .DRR., .GPCR., .MIG., .OP., .OPA., .OT., .PARK., .ST., .TGFB., .UBI.","Parkinson disease; Apoptosis signaling pathway","ENDOPLASMIC RETICULUM CHAPERONE BIP","cellular response to antibiotic; cellular response to calcium ion; cellular response to cAMP; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to interleukin-4; cellular response to manganese ion; cellular response to nerve growth factor stimulus; cellular response to unfolded protein; cellular response to xenobiotic stimulus; cerebellar Purkinje cell layer development; cerebellum structural organization; chaperone cofactor-dependent protein refolding; endoplasmic reticulum unfolded protein response; ER overload response; luteolysis; maintenance of protein localization in endoplasmic reticulum; negative regulation of apoptotic process; negative regulation of IRE1-mediated unfolded protein response; negative regulation of protein-containing complex assembly; negative regulation of transforming growth factor beta receptor signaling pathway; neuron apoptotic process; neuron differentiation; positive regulation of cell migration; positive regulation of neuron projection development; positive regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; post-translational protein targeting to membrane, translocation; protein folding in endoplasmic reticulum; protein refolding; proteolysis involved in protein catabolic process; regulation of ATF6-mediated unfolded protein response; regulation of IRE1-mediated unfolded protein response; regulation of PERK-mediated unfolded protein response; regulation of protein folding in endoplasmic reticulum; response to cocaine; response to endoplasmic reticulum stress; response to methamphetamine hydrochloride; response to radiation; stress response to metal ion; substantia nigra development; toxin transport; ubiquitin-dependent ERAD pathway","ATP binding; ATP hydrolysis activity; ATP-dependent protein folding chaperone; cadherin binding; calcium ion binding; chaperone binding; enzyme binding; heat shock protein binding; hydrolase activity; misfolded protein binding; nucleotide binding; protein binding; protein domain specific binding; protein folding chaperone; ribosome binding; ubiquitin protein ligase binding; unfolded protein binding","cell surface; COP9 signalosome; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; focal adhesion; intracellular membrane-bounded organelle; melanosome; membrane; midbody; mitochondrion; nucleus; plasma membrane; protein-containing complex; smooth endoplasmic reticulum","Translational control / RNA regulation","heat shock protein family A (Hsp70) member 5","http://www.ncbi.nlm.nih.gov/gene/?term=3309","3309","14828",null,null,null,"703193","P11021","P20029","A0A8L2QDI1","A0A8I3NCJ5","A0A287BIL8","F7C3R1","GO:0009986; GO:0008180; GO:0005737; GO:0005829; GO:0005783; GO:0034663; GO:0005788; GO:0005789; GO:0005793; GO:0070062; GO:0005925; GO:0043231; GO:0042470; GO:0016020; GO:0030496; GO:0005739; GO:0005634; GO:0005886; GO:0032991; GO:0005790","GO:0005524; GO:0016887; GO:0140662; GO:0045296; GO:0005509; GO:0051087; GO:0019899; GO:0031072; GO:0016787; GO:0051787; GO:0000166; GO:0005515; GO:0019904; GO:0044183; GO:0043022; GO:0031625; GO:0051082","GO:0071236; GO:0071277; GO:0071320; GO:0071480; GO:0042149; GO:0071353; GO:0071287; GO:1990090; GO:0034620; GO:0071466; GO:0021680; GO:0021589; GO:0051085; GO:0030968; GO:0006983; GO:0001554; GO:0035437; GO:0043066; GO:1903895; GO:0031333; GO:0030512; GO:0051402; GO:0030182; GO:0030335; GO:0010976; GO:0031398; GO:1990440; GO:0031204; GO:0034975; GO:0042026; GO:0051603; GO:1903891; GO:1903894; GO:1903897; GO:0060904; GO:0042220; GO:0034976; GO:1904313; GO:0009314; GO:0097501; GO:0021762; GO:1901998; GO:0030433","PTHR19375:SF380","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5238|UniProtKB=P11021","P00049; P00006"]
["Bmi1",null,"BMI1","43, 41","rb",null,6,1.1000000000000001,4,1.1000000000000001,4,4,"# 1357",".APO., .BCR., .CCP., .CD., .CP., .CSP., .IMU., .IMUF., .IMUR., .OP., .OT., .TRASR., .UBI.",null,"POLYCOMB COMPLEX PROTEIN BMI-1","apoptotic signaling pathway; brain development; cellular response to dexamethasone stimulus; cellular response to interleukin-1; chromatin organization; DNA methylation; embryonic skeletal system development; embryonic skeletal system morphogenesis; hemopoiesis; histone acetylation; histone H2A-K119 monoubiquitination; histone ubiquitination; humoral immune response; in utero embryonic development; negative regulation of apoptotic signaling pathway; negative regulation of gene expression, epigenetic; negative regulation of transcription by RNA polymerase II; positive regulation of B cell proliferation; positive regulation of fibroblast proliferation; positive regulation of immature T cell proliferation in thymus; positive regulation of ubiquitin-protein transferase activity; regulation of adaxial/abaxial pattern formation; regulation of gene expression; rostrocaudal neural tube patterning; segment specification; skeletal system development; somatic stem cell division","chromatin binding; metal ion binding; promoter-specific chromatin binding; protein binding; RING-like zinc finger domain binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; ubiquitin-protein transferase activator activity; zinc ion binding","cytoplasm; cytosol; heterochromatin; nuclear body; nucleoplasm; nucleus; PcG protein complex; PRC1 complex; ubiquitin ligase complex","Chromatin regulation / epigenetics","BMI1 proto-oncogene, polycomb ring finger","http://www.ncbi.nlm.nih.gov/gene/?term=100532731","100532731","12151","307151","487097",null,null,"P35226","P25916","B4F7B6","A0A8I3MY48","F2Z5D1","F6T8I5","GO:0005737; GO:0005829; GO:0000792; GO:0016604; GO:0005654; GO:0005634; GO:0031519; GO:0035102; GO:0000151","GO:0003682; GO:0046872; GO:1990841; GO:0005515; GO:0071535; GO:0000978; GO:0043565; GO:0097027; GO:0008270","GO:0097190; GO:0007420; GO:0071549; GO:0071347; GO:0006325; GO:0006306; GO:0048706; GO:0048704; GO:0030097; GO:0016573; GO:0036353; GO:0016574; GO:0006959; GO:0001701; GO:2001234; GO:0045814; GO:0000122; GO:0030890; GO:0048146; GO:0033092; GO:0051443; GO:2000011; GO:0010468; GO:0021903; GO:0007379; GO:0001501; GO:0048103","PTHR10825:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1066|UniProtKB=P35226"]
["Bmi1",null,"BMI1","43, 41","rb",null,1,4,4,4,4,4,"# 1457",".APO., .BCR., .CCP., .CD., .CP., .CSP., .IMU., .IMUF., .IMUR., .OP., .OT., .TRASR., .UBI.",null,"POLYCOMB COMPLEX PROTEIN BMI-1","apoptotic signaling pathway; brain development; cellular response to dexamethasone stimulus; cellular response to interleukin-1; chromatin organization; DNA methylation; embryonic skeletal system development; embryonic skeletal system morphogenesis; hemopoiesis; histone acetylation; histone H2A-K119 monoubiquitination; histone ubiquitination; humoral immune response; in utero embryonic development; negative regulation of apoptotic signaling pathway; negative regulation of gene expression, epigenetic; negative regulation of transcription by RNA polymerase II; positive regulation of B cell proliferation; positive regulation of fibroblast proliferation; positive regulation of immature T cell proliferation in thymus; positive regulation of ubiquitin-protein transferase activity; regulation of adaxial/abaxial pattern formation; regulation of gene expression; rostrocaudal neural tube patterning; segment specification; skeletal system development; somatic stem cell division","chromatin binding; metal ion binding; promoter-specific chromatin binding; protein binding; RING-like zinc finger domain binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; ubiquitin-protein transferase activator activity; zinc ion binding","cytoplasm; cytosol; heterochromatin; nuclear body; nucleoplasm; nucleus; PcG protein complex; PRC1 complex; ubiquitin ligase complex","Chromatin regulation / epigenetics","BMI1 proto-oncogene, polycomb ring finger","http://www.ncbi.nlm.nih.gov/gene/?term=100532731","100532731","12151","307151","487097",null,null,"P35226","P25916","B4F7B6","A0A8I3MY48","F2Z5D1","F6T8I5","GO:0005737; GO:0005829; GO:0000792; GO:0016604; GO:0005654; GO:0005634; GO:0031519; GO:0035102; GO:0000151","GO:0003682; GO:0046872; GO:1990841; GO:0005515; GO:0071535; GO:0000978; GO:0043565; GO:0097027; GO:0008270","GO:0097190; GO:0007420; GO:0071549; GO:0071347; GO:0006325; GO:0006306; GO:0048706; GO:0048704; GO:0030097; GO:0016573; GO:0036353; GO:0016574; GO:0006959; GO:0001701; GO:2001234; GO:0045814; GO:0000122; GO:0030890; GO:0048146; GO:0033092; GO:0051443; GO:2000011; GO:0010468; GO:0021903; GO:0007379; GO:0001501; GO:0048103","PTHR10825:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1066|UniProtKB=P35226"]
["BMP4",null,"BMP4","46","rb",null,1,8,8,8,1,8,"# 0936",".ANG., .APO., .BMP., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HIPPO., .IMUF., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway","BONE MORPHOGENETIC PROTEIN 4","ameloblast differentiation; anatomical structure development; anatomical structure formation involved in morphogenesis; angiogenesis; anterior/posterior axis specification; aortic valve morphogenesis; apoptotic process involved in endocardial cushion morphogenesis; blood vessel development; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; BMP signaling pathway; BMP signaling pathway involved in heart development; BMP signaling pathway involved in heart induction; BMP signaling pathway involved in nephric duct formation; BMP signaling pathway involved in renal system segmentation; BMP signaling pathway involved in ureter morphogenesis; bone development; branching involved in prostate gland morphogenesis; branching involved in ureteric bud morphogenesis; branching morphogenesis of an epithelial tube; bronchus development; bud dilation involved in lung branching; bud elongation involved in lung branching; camera-type eye development; camera-type eye morphogenesis; cardiac jelly development; cardiac muscle cell differentiation; cardiac right ventricle morphogenesis; cardiac septum development; cartilage development; cell differentiation; cell fate commitment; cell population proliferation; cellular response to BMP stimulus; cellular response to growth factor stimulus; chondrocyte differentiation; cloacal septation; common-partner SMAD protein phosphorylation; coronary vasculature development; cranial suture morphogenesis; deltoid tuberosity development; dorsal/ventral neural tube patterning; embryonic cranial skeleton morphogenesis; embryonic digit morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic morphogenesis; embryonic skeletal joint morphogenesis; embryonic skeletal system development; embryonic skeletal system morphogenesis; endocardial cushion development; endochondral ossification; endoderm development; epithelial cell proliferation; epithelial cell proliferation involved in lung morphogenesis; epithelial to mesenchymal transition involved in endocardial cushion formation; epithelial tube branching involved in lung morphogenesis; epithelial-mesenchymal cell signaling; epithelium development; erythrocyte differentiation; forebrain development; gene expression; germ cell development; glomerular capillary formation; heart development; hematopoietic progenitor cell differentiation; inner ear auditory receptor cell differentiation; intermediate mesodermal cell differentiation; kidney development; lens induction in camera-type eye; lung alveolus development; lung development; lung morphogenesis; lymphoid progenitor cell differentiation; macrophage differentiation; mammary gland formation; membranous septum morphogenesis; mesenchymal cell differentiation involved in kidney development; mesenchymal cell differentiation involved in renal system development; mesenchymal cell proliferation involved in ureter development; mesenchymal cell proliferation involved in ureteric bud development; mesenchymal to epithelial transition involved in metanephros morphogenesis; mesoderm formation; mesodermal cell differentiation; mesodermal cell fate determination; mesonephros development; metanephric collecting duct development; metanephros development; monocyte differentiation; muscular septum morphogenesis; negative regulation of apoptotic process; negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; negative regulation of branching involved in ureteric bud morphogenesis; negative regulation of cell cycle; negative regulation of cell death; negative regulation of cell population proliferation; negative regulation of cell proliferation involved in heart morphogenesis; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of gene expression; negative regulation of glomerular mesangial cell proliferation; negative regulation of glomerulus development; negative regulation of immature T cell proliferation in thymus; negative regulation of MAP kinase activity; negative regulation of mesenchymal cell proliferation involved in ureter development; negative regulation of metanephric comma-shaped body morphogenesis; negative regulation of metanephric S-shaped body morphogenesis; negative regulation of miRNA transcription; negative regulation of mitotic nuclear division; negative regulation of myoblast differentiation; negative regulation of phosphorylation; negative regulation of prostatic bud formation; negative regulation of striated muscle tissue development; negative regulation of T cell differentiation in thymus; negative regulation of thymocyte apoptotic process; negative regulation of transcription by RNA polymerase II; negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular associated smooth muscle cell proliferation; neural tube closure; neuron fate commitment; odontogenesis; odontogenesis of dentin-containing tooth; organ induction; ossification; osteoblast differentiation; outflow tract morphogenesis; outflow tract septum morphogenesis; pericyte cell differentiation; pharyngeal arch artery morphogenesis; pituitary gland development; podocyte development; positive chemotaxis; positive regulation of apoptotic process; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of branching involved in lung morphogenesis; positive regulation of cardiac muscle fiber development; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; positive regulation of cartilage development; positive regulation of cell death; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell proliferation involved in outflow tract morphogenesis; positive regulation of collagen biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epidermal cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of kidney development; positive regulation of MAPK cascade; positive regulation of miRNA maturation; positive regulation of neuron differentiation; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of p38MAPK cascade; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of protein binding; positive regulation of protein phosphorylation; positive regulation of SMAD protein signal transduction; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; post-embryonic development; prostate gland morphogenesis; prostatic bud formation; protein localization to nucleus; pulmonary artery endothelial tube morphogenesis; pulmonary valve morphogenesis; regulation of branching involved in prostate gland morphogenesis; regulation of cartilage development; regulation of cell differentiation; regulation of cell fate commitment; regulation of gene expression; regulation of mesodermal cell differentiation; regulation of miRNA transcription; regulation of morphogenesis of a branching structure; regulation of odontogenesis of dentin-containing tooth; regulation of pathway-restricted SMAD protein phosphorylation; regulation of protein import into nucleus; regulation of smooth muscle cell differentiation; regulation of smooth muscle cell proliferation; renal system process; secondary heart field specification; sinoatrial node development; skeletal system development; SMAD protein signal transduction; smooth muscle cell differentiation; smooth muscle tissue development; specification of animal organ position; specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; steroid hormone mediated signaling pathway; telencephalon development; telencephalon regionalization; tendon cell differentiation; trachea development; trachea formation; transcription by RNA polymerase II; type B pancreatic cell development; ureter epithelial cell differentiation; ureter smooth muscle cell differentiation; ureteric bud development; vasculature development","BMP receptor binding; chemoattractant activity; co-receptor binding; cytokine activity; growth factor activity; heparin binding; protein binding","endoplasmic reticulum lumen; extracellular region; extracellular space","TGF-beta / Smad signaling","bone morphogenetic protein 4","http://www.ncbi.nlm.nih.gov/gene/?term=652","652","12159",null,"490695","100113425","694618","P12644","P21275","A0A0G2K9V2","A0A8I3MKS3","A7LJT9","F7ACJ7","GO:0005788; GO:0005576; GO:0005615","GO:0070700; GO:0042056; GO:0039706; GO:0005125; GO:0008083; GO:0008201; GO:0005515","GO:0036305; GO:0048856; GO:0048646; GO:0001525; GO:0009948; GO:0003180; GO:0003277; GO:0001568; GO:0002043; GO:0030509; GO:0061312; GO:0003130; GO:0071893; GO:0061151; GO:0061149; GO:0060348; GO:0060442; GO:0001658; GO:0048754; GO:0060433; GO:0060503; GO:0060449; GO:0043010; GO:0048593; GO:1905072; GO:0055007; GO:0003215; GO:0003279; GO:0051216; GO:0030154; GO:0045165; GO:0008283; GO:0071773; GO:0071363; GO:0002062; GO:0060197; GO:0007182; GO:0060976; GO:0060363; GO:0035993; GO:0021904; GO:0048701; GO:0042733; GO:0035116; GO:0030326; GO:0048598; GO:0060272; GO:0048706; GO:0048704; GO:0003197; GO:0001958; GO:0007492; GO:0050673; GO:0060502; GO:0003198; GO:0060441; GO:0060684; GO:0060429; GO:0030218; GO:0030900; GO:0010467; GO:0007281; GO:0072104; GO:0007507; GO:0002244; GO:0042491; GO:0048392; GO:0001822; GO:0060235; GO:0048286; GO:0030324; GO:0060425; GO:0002320; GO:0030225; GO:0060592; GO:0003149; GO:0072161; GO:2001012; GO:0072198; GO:0072138; GO:0003337; GO:0001707; GO:0048333; GO:0007500; GO:0001823; GO:0072205; GO:0001656; GO:0030224; GO:0003150; GO:0043066; GO:0072097; GO:0090191; GO:0045786; GO:0060548; GO:0008285; GO:2000137; GO:0032331; GO:0045892; GO:0050680; GO:2001237; GO:0010629; GO:0072125; GO:0090194; GO:0033088; GO:0043407; GO:0072200; GO:2000007; GO:2000005; GO:1902894; GO:0045839; GO:0045662; GO:0042326; GO:0060686; GO:0045843; GO:0033085; GO:0070244; GO:0000122; GO:1904753; GO:1904706; GO:0001843; GO:0048663; GO:0042476; GO:0042475; GO:0001759; GO:0001503; GO:0001649; GO:0003151; GO:0003148; GO:1904238; GO:0061626; GO:0021983; GO:0072015; GO:0050918; GO:0043065; GO:0030513; GO:0030501; GO:0061047; GO:0055020; GO:1905312; GO:0061036; GO:0010942; GO:0030335; GO:0008284; GO:1901964; GO:0032967; GO:0045893; GO:0045603; GO:0010595; GO:0001938; GO:0045606; GO:0030858; GO:0050679; GO:0010718; GO:0070374; GO:0010628; GO:0090184; GO:0043410; GO:1903800; GO:0045666; GO:0045778; GO:0045669; GO:1900745; GO:0010862; GO:0032092; GO:0001934; GO:0060391; GO:0048661; GO:0045944; GO:0009791; GO:0060512; GO:0060513; GO:0034504; GO:0061155; GO:0003184; GO:0060687; GO:0061035; GO:0045595; GO:0010453; GO:0010468; GO:1905770; GO:1902893; GO:0060688; GO:0042487; GO:0060393; GO:0042306; GO:0051150; GO:0048660; GO:0003014; GO:0003139; GO:0003163; GO:0001501; GO:0060395; GO:0051145; GO:0048745; GO:0010159; GO:0072101; GO:0043401; GO:0021537; GO:0021978; GO:0035990; GO:0060438; GO:0060440; GO:0006366; GO:0003323; GO:0072192; GO:0072193; GO:0001657; GO:0001944","PTHR11848:SF165","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1071|UniProtKB=P12644","P00052; P06664"]
["B-Myb",null,"MYBL2","80","ms",null,4,4,"n/a","n/a","n/a","n/a","# 2853",".APO., .CCP., .CCY., .CD., .CSP., .OP., .OT., .TRASR.",null,"MYB-RELATED PROTEIN B","cellular response to leukemia inhibitory factor; mitotic cell cycle; mitotic spindle assembly; positive regulation of neuron apoptotic process; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","Myb complex; nucleoplasm; nucleus",null,"MYB proto-oncogene like 2","http://www.ncbi.nlm.nih.gov/gene/?term=4605","4605","17865","296344",null,null,"694693","P10244","P48972","D3ZLC6","A0A8I3NJJ3","A0A287ATG9","A0A5K1UA99","GO:0031523; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0000981; GO:0005515; GO:0000978; GO:1990837","GO:1990830; GO:0000278; GO:0090307; GO:0043525; GO:0045944; GO:0006355","PTHR45614:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7548|UniProtKB=P10244"]
["B-Myb (MYBL2)",null,"MYBL2","100","gt",null,6,7,"n/a","n/a","n/a","n/a","# 1113",".APO., .CCP., .CCY., .CD., .CSP., .OP., .OT., .TRASR.",null,"MYB-RELATED PROTEIN B","cellular response to leukemia inhibitory factor; mitotic cell cycle; mitotic spindle assembly; positive regulation of neuron apoptotic process; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","Myb complex; nucleoplasm; nucleus",null,"MYB proto-oncogene like 2","http://www.ncbi.nlm.nih.gov/gene/?term=4605","4605","17865","296344",null,null,"694693","P10244","P48972","D3ZLC6","A0A8I3NJJ3","A0A287ATG9","A0A5K1UA99","GO:0031523; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0000981; GO:0005515; GO:0000978; GO:1990837","GO:1990830; GO:0000278; GO:0090307; GO:0043525; GO:0045944; GO:0006355","PTHR45614:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7548|UniProtKB=P10244"]
["B-Myb (MYBL2) - phospho","Thr487","MYBL2","110","rb",null,6,4,"n/a","n/a","n/a","n/a","# 1112",".APO., .CCP., .CCY., .CD., .CSP., .OP., .OT., .TRASR.",null,"MYB-RELATED PROTEIN B","cellular response to leukemia inhibitory factor; mitotic cell cycle; mitotic spindle assembly; positive regulation of neuron apoptotic process; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","Myb complex; nucleoplasm; nucleus",null,"MYB proto-oncogene like 2","http://www.ncbi.nlm.nih.gov/gene/?term=4605","4605","17865","296344",null,null,"694693","P10244","P48972","D3ZLC6","A0A8I3NJJ3","A0A287ATG9","A0A5K1UA99","GO:0031523; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0000981; GO:0005515; GO:0000978; GO:1990837","GO:1990830; GO:0000278; GO:0090307; GO:0043525; GO:0045944; GO:0006355","PTHR45614:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7548|UniProtKB=P10244"]
["Bok",null,"BOK","18","rb",null,4,1.1000000000000001,6,7,4,4,"BG/MP # 086",".APH., .APO., .CCP., .CD., .CP., .CSP., .DDR., .OP., .OPA., .P53S., .ST.","Apoptosis signaling pathway","BCL-2-RELATED OVARIAN KILLER PROTEIN","activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic process; brain development; cellular component disassembly involved in execution phase of apoptosis; extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage; male gonad development; negative regulation of mitochondrial depolarization; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; negative regulation of necroptotic process; negative regulation of neuron apoptotic process; neuron apoptotic process; oligodendrocyte differentiation; positive regulation of apoptotic process; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of execution phase of apoptosis; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of PERK-mediated unfolded protein response; protein complex oligomerization; regulation of apoptotic process; regulation of autophagy; regulation of chorionic trophoblast cell proliferation; regulation of cytosolic calcium ion concentration; regulation of granulosa cell apoptotic process; release of cytochrome c from mitochondria","BH domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; protein-containing complex binding; signaling receptor binding; ubiquitin protein ligase binding","cis-Golgi network membrane; cytoplasm; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; Golgi apparatus; membrane; mitochondrial inner membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nuclear outer membrane; nucleus; recycling endosome membrane; trans-Golgi network membrane","Apoptosis","BCL2 family apoptosis regulator BOK","http://www.ncbi.nlm.nih.gov/gene/?term=666","666","51800","29884",null,null,null,"Q9UMX3","O35425","Q792S6",null,null,null,"GO:0033106; GO:0005737; GO:0031901; GO:0005783; GO:0005789; GO:0005768; GO:0005794; GO:0016020; GO:0005743; GO:0031966; GO:0005741; GO:0005739; GO:0005640; GO:0005634; GO:0055038; GO:0032588","GO:0051400; GO:0005515; GO:0046983; GO:0046982; GO:0042803; GO:0044877; GO:0005102; GO:0031625","GO:0006919; GO:0008635; GO:0006915; GO:0007420; GO:0006921; GO:0097192; GO:0072332; GO:0008630; GO:0008584; GO:0051902; GO:1901029; GO:0060546; GO:0043524; GO:0051402; GO:0048709; GO:0043065; GO:1902237; GO:1900119; GO:2001244; GO:1901030; GO:1903899; GO:0051259; GO:0042981; GO:0010506; GO:1901382; GO:0051480; GO:1904708; GO:0001836","PTHR11256:SF48","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1087|UniProtKB=Q9UMX3","P00006"]
["Brachyury",null,"TBXT","47","rb",null,2,2,2,8,1,2,"# 0930",".CSP., .DEV., .OP., .OPA., .OT., .ST., .TRASR., .WNT.","Wnt signaling pathway","T-BOX TRANSCRIPTION FACTOR T","anterior/posterior axis specification, embryo; cardiac muscle cell myoblast differentiation; cell fate specification; heart morphogenesis; mesoderm development; mesoderm formation; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; primitive streak formation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; signal transduction; somitogenesis","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding","chromatin; nucleoplasm; nucleus","Stem cell marker","T-box transcription factor T","http://www.ncbi.nlm.nih.gov/gene/?term=6862","6862","20997",null,null,null,null,"O15178","P20293","A0A8I6AEA5","A0A8I3MTQ9",null,"F7ARP2","GO:0000785; GO:0005654; GO:0005634","GO:0003677; GO:0003700; GO:0000981; GO:0000978; GO:0061629; GO:1990837","GO:0008595; GO:0060379; GO:0001708; GO:0003007; GO:0007498; GO:0001707; GO:0043433; GO:0000122; GO:0045893; GO:0045944; GO:0090009; GO:0006355; GO:0006357; GO:0007165; GO:0001756","PTHR11267:SF83","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11515|UniProtKB=O15178","P00057"]
["Brachyury",null,"TBXT","26","gt",null,2,8,"n/a","n/a","n/a","n/a","# 2867",".CSP., .DEV., .OP., .OPA., .OT., .ST., .TRASR., .WNT.","Wnt signaling pathway","T-BOX TRANSCRIPTION FACTOR T","anterior/posterior axis specification, embryo; cardiac muscle cell myoblast differentiation; cell fate specification; heart morphogenesis; mesoderm development; mesoderm formation; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; primitive streak formation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; signal transduction; somitogenesis","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding","chromatin; nucleoplasm; nucleus","Stem cell marker","T-box transcription factor T","http://www.ncbi.nlm.nih.gov/gene/?term=6862","6862","20997",null,null,null,null,"O15178","P20293","A0A8I6AEA5","A0A8I3MTQ9",null,"F7ARP2","GO:0000785; GO:0005654; GO:0005634","GO:0003677; GO:0003700; GO:0000981; GO:0000978; GO:0061629; GO:1990837","GO:0008595; GO:0060379; GO:0001708; GO:0003007; GO:0007498; GO:0001707; GO:0043433; GO:0000122; GO:0045893; GO:0045944; GO:0090009; GO:0006355; GO:0006357; GO:0007165; GO:0001756","PTHR11267:SF83","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11515|UniProtKB=O15178","P00057"]
["B-Raf",null,"BRAF","95","rb",null,1.1000000000000001,8,3,3,1,2,"TK # 036",".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE B-RAF","alpha-beta T cell differentiation; animal organ morphogenesis; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; CD4-positive, alpha-beta T cell differentiation; cell differentiation; cellular response to calcium ion; cellular response to xenobiotic stimulus; endothelial cell apoptotic process; epidermal growth factor receptor signaling pathway; ERK1 and ERK2 cascade; establishment of protein localization to membrane; face development; head morphogenesis; long-term synaptic potentiation; MAPK cascade; metabolic process; myeloid progenitor cell differentiation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of fibroblast migration; negative regulation of neuron apoptotic process; negative regulation of synaptic vesicle exocytosis; phosphorylation; positive regulation of axon regeneration; positive regulation of axonogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose transmembrane transport; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; positive T cell selection; protein modification process; protein phosphorylation; regulation of axon regeneration; regulation of cell population proliferation; regulation of T cell differentiation; signal transduction; somatic stem cell population maintenance; stress fiber assembly; substrate adhesion-dependent cell spreading; synaptic vesicle exocytosis; T cell differentiation in thymus; T cell receptor signaling pathway; thymus development; thyroid gland development; trehalose metabolism in response to stress; visual learning","ATP binding; calcium ion binding; catalytic activity; identical protein binding; kinase activity; MAP kinase kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; scaffold protein binding; small GTPase binding; transferase activity","cell body; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; neuron projection; nucleus; plasma membrane; presynapse","MAPK signaling","B-Raf proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=673","673","109880","114486",null,null,null,"P15056","P28028","A0A8I6ADL5","A0A8I3QBG2","A0A286ZJW4","A0A1D5Q239","GO:0044297; GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005739; GO:0043005; GO:0005634; GO:0005886; GO:0098793","GO:0005524; GO:0005509; GO:0003824; GO:0042802; GO:0016301; GO:0004708; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0097110; GO:0031267; GO:0016740","GO:0046632; GO:0009887; GO:0043369; GO:0043367; GO:0030154; GO:0071277; GO:0071466; GO:0072577; GO:0007173; GO:0070371; GO:0090150; GO:0060324; GO:0060323; GO:0060291; GO:0000165; GO:0008152; GO:0002318; GO:0043066; GO:2000352; GO:0010764; GO:0043524; GO:2000301; GO:0016310; GO:0048680; GO:0050772; GO:0070374; GO:0010628; GO:0010828; GO:0033138; GO:0001934; GO:0051496; GO:1900026; GO:0043368; GO:0036211; GO:0006468; GO:0048679; GO:0042127; GO:0045580; GO:0007165; GO:0035019; GO:0043149; GO:0034446; GO:0016079; GO:0033077; GO:0050852; GO:0048538; GO:0030878; GO:0070413; GO:0008542","PTHR44329:SF240","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1097|UniProtKB=P15056","P06959; P00053; P00010; P00056; P00036; P04393; P00034; P00047; P00005; P00018; P00031"]
["B-Raf - phospho","Ser445","BRAF","86","rb",null,2,1,1,1,1,1,"# 2459",".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE B-RAF","alpha-beta T cell differentiation; animal organ morphogenesis; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; CD4-positive, alpha-beta T cell differentiation; cell differentiation; cellular response to calcium ion; cellular response to xenobiotic stimulus; endothelial cell apoptotic process; epidermal growth factor receptor signaling pathway; ERK1 and ERK2 cascade; establishment of protein localization to membrane; face development; head morphogenesis; long-term synaptic potentiation; MAPK cascade; metabolic process; myeloid progenitor cell differentiation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of fibroblast migration; negative regulation of neuron apoptotic process; negative regulation of synaptic vesicle exocytosis; phosphorylation; positive regulation of axon regeneration; positive regulation of axonogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose transmembrane transport; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; positive T cell selection; protein modification process; protein phosphorylation; regulation of axon regeneration; regulation of cell population proliferation; regulation of T cell differentiation; signal transduction; somatic stem cell population maintenance; stress fiber assembly; substrate adhesion-dependent cell spreading; synaptic vesicle exocytosis; T cell differentiation in thymus; T cell receptor signaling pathway; thymus development; thyroid gland development; trehalose metabolism in response to stress; visual learning","ATP binding; calcium ion binding; catalytic activity; identical protein binding; kinase activity; MAP kinase kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; scaffold protein binding; small GTPase binding; transferase activity","cell body; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; neuron projection; nucleus; plasma membrane; presynapse","MAPK signaling","B-Raf proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=673","673","109880","114486",null,null,null,"P15056","P28028","A0A8I6ADL5","A0A8I3QBG2","A0A286ZJW4","A0A1D5Q239","GO:0044297; GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005739; GO:0043005; GO:0005634; GO:0005886; GO:0098793","GO:0005524; GO:0005509; GO:0003824; GO:0042802; GO:0016301; GO:0004708; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0097110; GO:0031267; GO:0016740","GO:0046632; GO:0009887; GO:0043369; GO:0043367; GO:0030154; GO:0071277; GO:0071466; GO:0072577; GO:0007173; GO:0070371; GO:0090150; GO:0060324; GO:0060323; GO:0060291; GO:0000165; GO:0008152; GO:0002318; GO:0043066; GO:2000352; GO:0010764; GO:0043524; GO:2000301; GO:0016310; GO:0048680; GO:0050772; GO:0070374; GO:0010628; GO:0010828; GO:0033138; GO:0001934; GO:0051496; GO:1900026; GO:0043368; GO:0036211; GO:0006468; GO:0048679; GO:0042127; GO:0045580; GO:0007165; GO:0035019; GO:0043149; GO:0034446; GO:0016079; GO:0033077; GO:0050852; GO:0048538; GO:0030878; GO:0070413; GO:0008542","PTHR44329:SF240","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1097|UniProtKB=P15056","P06959; P00053; P00010; P00056; P00036; P04393; P00034; P00047; P00005; P00018; P00031"]
["B-Raf - phospho","Ser602","BRAF","84","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2401",".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE B-RAF","alpha-beta T cell differentiation; animal organ morphogenesis; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; CD4-positive, alpha-beta T cell differentiation; cell differentiation; cellular response to calcium ion; cellular response to xenobiotic stimulus; endothelial cell apoptotic process; epidermal growth factor receptor signaling pathway; ERK1 and ERK2 cascade; establishment of protein localization to membrane; face development; head morphogenesis; long-term synaptic potentiation; MAPK cascade; metabolic process; myeloid progenitor cell differentiation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of fibroblast migration; negative regulation of neuron apoptotic process; negative regulation of synaptic vesicle exocytosis; phosphorylation; positive regulation of axon regeneration; positive regulation of axonogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose transmembrane transport; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; positive T cell selection; protein modification process; protein phosphorylation; regulation of axon regeneration; regulation of cell population proliferation; regulation of T cell differentiation; signal transduction; somatic stem cell population maintenance; stress fiber assembly; substrate adhesion-dependent cell spreading; synaptic vesicle exocytosis; T cell differentiation in thymus; T cell receptor signaling pathway; thymus development; thyroid gland development; trehalose metabolism in response to stress; visual learning","ATP binding; calcium ion binding; catalytic activity; identical protein binding; kinase activity; MAP kinase kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; scaffold protein binding; small GTPase binding; transferase activity","cell body; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; neuron projection; nucleus; plasma membrane; presynapse",null,"B-Raf proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=673","673","109880","114486",null,null,null,"P15056","P28028","A0A8I6ADL5","A0A8I3QBG2","A0A286ZJW4","A0A1D5Q239","GO:0044297; GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005739; GO:0043005; GO:0005634; GO:0005886; GO:0098793","GO:0005524; GO:0005509; GO:0003824; GO:0042802; GO:0016301; GO:0004708; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0097110; GO:0031267; GO:0016740","GO:0046632; GO:0009887; GO:0043369; GO:0043367; GO:0030154; GO:0071277; GO:0071466; GO:0072577; GO:0007173; GO:0070371; GO:0090150; GO:0060324; GO:0060323; GO:0060291; GO:0000165; GO:0008152; GO:0002318; GO:0043066; GO:2000352; GO:0010764; GO:0043524; GO:2000301; GO:0016310; GO:0048680; GO:0050772; GO:0070374; GO:0010628; GO:0010828; GO:0033138; GO:0001934; GO:0051496; GO:1900026; GO:0043368; GO:0036211; GO:0006468; GO:0048679; GO:0042127; GO:0045580; GO:0007165; GO:0035019; GO:0043149; GO:0034446; GO:0016079; GO:0033077; GO:0050852; GO:0048538; GO:0030878; GO:0070413; GO:0008542","PTHR44329:SF240","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1097|UniProtKB=P15056","P06959; P00053; P00010; P00056; P00036; P04393; P00034; P00047; P00005; P00018; P00031"]
["B-Raf - phospho","Ser729","BRAF","84","rb",null,4,1.1000000000000001,"n/a","n/a","n/a","n/a","# 2338",".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE B-RAF","alpha-beta T cell differentiation; animal organ morphogenesis; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; CD4-positive, alpha-beta T cell differentiation; cell differentiation; cellular response to calcium ion; cellular response to xenobiotic stimulus; endothelial cell apoptotic process; epidermal growth factor receptor signaling pathway; ERK1 and ERK2 cascade; establishment of protein localization to membrane; face development; head morphogenesis; long-term synaptic potentiation; MAPK cascade; metabolic process; myeloid progenitor cell differentiation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of fibroblast migration; negative regulation of neuron apoptotic process; negative regulation of synaptic vesicle exocytosis; phosphorylation; positive regulation of axon regeneration; positive regulation of axonogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose transmembrane transport; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; positive T cell selection; protein modification process; protein phosphorylation; regulation of axon regeneration; regulation of cell population proliferation; regulation of T cell differentiation; signal transduction; somatic stem cell population maintenance; stress fiber assembly; substrate adhesion-dependent cell spreading; synaptic vesicle exocytosis; T cell differentiation in thymus; T cell receptor signaling pathway; thymus development; thyroid gland development; trehalose metabolism in response to stress; visual learning","ATP binding; calcium ion binding; catalytic activity; identical protein binding; kinase activity; MAP kinase kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; scaffold protein binding; small GTPase binding; transferase activity","cell body; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; neuron projection; nucleus; plasma membrane; presynapse",null,"B-Raf proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=673","673","109880","114486",null,null,null,"P15056","P28028","A0A8I6ADL5","A0A8I3QBG2","A0A286ZJW4","A0A1D5Q239","GO:0044297; GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005739; GO:0043005; GO:0005634; GO:0005886; GO:0098793","GO:0005524; GO:0005509; GO:0003824; GO:0042802; GO:0016301; GO:0004708; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0097110; GO:0031267; GO:0016740","GO:0046632; GO:0009887; GO:0043369; GO:0043367; GO:0030154; GO:0071277; GO:0071466; GO:0072577; GO:0007173; GO:0070371; GO:0090150; GO:0060324; GO:0060323; GO:0060291; GO:0000165; GO:0008152; GO:0002318; GO:0043066; GO:2000352; GO:0010764; GO:0043524; GO:2000301; GO:0016310; GO:0048680; GO:0050772; GO:0070374; GO:0010628; GO:0010828; GO:0033138; GO:0001934; GO:0051496; GO:1900026; GO:0043368; GO:0036211; GO:0006468; GO:0048679; GO:0042127; GO:0045580; GO:0007165; GO:0035019; GO:0043149; GO:0034446; GO:0016079; GO:0033077; GO:0050852; GO:0048538; GO:0030878; GO:0070413; GO:0008542","PTHR44329:SF240","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1097|UniProtKB=P15056","P06959; P00053; P00010; P00056; P00036; P04393; P00034; P00047; P00005; P00018; P00031"]
["BRCA1",null,"BRCA1","220","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1003",".ANG., .APO., .BRC., .CANCER., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .ST., .TNF., .TRASR., .UBI.",null,"BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN","cell cycle; cellular response to DNA damage stimulus; cellular response to indole-3-methanol; cellular response to ionizing radiation; cellular response to tumor necrosis factor; centrosome cycle; chordate embryonic development; chromosome segregation; DNA recombination; DNA repair; DNA strand resection involved in replication fork processing; dosage compensation by inactivation of X chromosome; double-strand break repair; double-strand break repair via homologous recombination; fatty acid biosynthetic process; fatty acid metabolic process; histone H2A K63-linked deubiquitination; histone H2A monoubiquitination; homologous recombination; intrinsic apoptotic signaling pathway in response to DNA damage; lipid metabolic process; localization; mitotic G2 DNA damage checkpoint signaling; mitotic G2/M transition checkpoint; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of centriole replication; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of fatty acid biosynthetic process; negative regulation of histone acetylation; negative regulation of histone H3-K4 methylation; negative regulation of histone H3-K9 methylation; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of reactive oxygen species metabolic process; positive regulation of angiogenesis; positive regulation of DNA repair; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of histone acetylation; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 acetylation; positive regulation of histone H3-K9 methylation; positive regulation of histone H4-K16 acetylation; positive regulation of histone H4-K20 methylation; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial growth factor production; postreplication repair; protein autoubiquitination; protein K6-linked ubiquitination; protein polyubiquitination; protein ubiquitination; regulation of cell cycle; regulation of DNA damage checkpoint; regulation of DNA methylation; regulation of DNA repair; regulation of gene expression by genomic imprinting; regulation of transcription by RNA polymerase II; response to estrogen; response to ionizing radiation; response to stimulus","damaged DNA binding; DNA binding; enzyme binding; identical protein binding; metal ion binding; p53 binding; protein binding; RNA binding; RNA polymerase binding; transcription cis-regulatory region binding; transcription coactivator activity; transferase activity; tubulin binding; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding","BRCA1-A complex; BRCA1-B complex; BRCA1-BARD1 complex; BRCA1-C complex; chromosome; condensed chromosome; condensed nuclear chromosome; cytoplasm; DNA repair complex; gamma-tubulin ring complex; intracellular non-membrane-bounded organelle; lateral element; male germ cell nucleus; nuclear body; nuclear ubiquitin ligase complex; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ribonucleoprotein complex; ubiquitin ligase complex; XY body","DNA damage","BRCA1 DNA repair associated","http://www.ncbi.nlm.nih.gov/gene/?term=672","672","12189",null,null,"100049662",null,"P38398","P48754","A0A0G2K2T3","A0A8I3MRE9","A0A286ZS33","F6PQM4","GO:0070531; GO:0070532; GO:0031436; GO:0070533; GO:0005694; GO:0000793; GO:0000794; GO:0005737; GO:1990391; GO:0000931; GO:0043232; GO:0000800; GO:0001673; GO:0016604; GO:0000152; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:1990904; GO:0000151; GO:0001741","GO:0003684; GO:0003677; GO:0019899; GO:0042802; GO:0046872; GO:0002039; GO:0005515; GO:0003723; GO:0070063; GO:0000976; GO:0003713; GO:0016740; GO:0015631; GO:0031625; GO:0004842; GO:0008270","GO:0007049; GO:0006974; GO:0071681; GO:0071479; GO:0071356; GO:0007098; GO:0043009; GO:0007059; GO:0006310; GO:0006281; GO:0110025; GO:0009048; GO:0006302; GO:0000724; GO:0006633; GO:0006631; GO:0070537; GO:0035518; GO:0035825; GO:0008630; GO:0006629; GO:0051179; GO:0007095; GO:0044818; GO:0045786; GO:0030308; GO:0046600; GO:0045892; GO:1902042; GO:0045717; GO:0035067; GO:0051572; GO:0051573; GO:0033147; GO:2000378; GO:0045766; GO:0045739; GO:0045893; GO:0010628; GO:0035066; GO:0051571; GO:2000617; GO:0051574; GO:2000620; GO:0070512; GO:0031398; GO:0045944; GO:0010575; GO:0006301; GO:0051865; GO:0085020; GO:0000209; GO:0016567; GO:0051726; GO:2000001; GO:0044030; GO:0006282; GO:0006349; GO:0006357; GO:0043627; GO:0010212; GO:0050896","PTHR13763:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1100|UniProtKB=P38398"]
["BRCA1 - phospho","Ser1524","BRCA1","220","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1018",".ANG., .APO., .BRC., .CANCER., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .ST., .TNF., .TRASR., .UBI.",null,"BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN","cell cycle; cellular response to DNA damage stimulus; cellular response to indole-3-methanol; cellular response to ionizing radiation; cellular response to tumor necrosis factor; centrosome cycle; chordate embryonic development; chromosome segregation; DNA recombination; DNA repair; DNA strand resection involved in replication fork processing; dosage compensation by inactivation of X chromosome; double-strand break repair; double-strand break repair via homologous recombination; fatty acid biosynthetic process; fatty acid metabolic process; histone H2A K63-linked deubiquitination; histone H2A monoubiquitination; homologous recombination; intrinsic apoptotic signaling pathway in response to DNA damage; lipid metabolic process; localization; mitotic G2 DNA damage checkpoint signaling; mitotic G2/M transition checkpoint; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of centriole replication; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of fatty acid biosynthetic process; negative regulation of histone acetylation; negative regulation of histone H3-K4 methylation; negative regulation of histone H3-K9 methylation; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of reactive oxygen species metabolic process; positive regulation of angiogenesis; positive regulation of DNA repair; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of histone acetylation; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 acetylation; positive regulation of histone H3-K9 methylation; positive regulation of histone H4-K16 acetylation; positive regulation of histone H4-K20 methylation; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial growth factor production; postreplication repair; protein autoubiquitination; protein K6-linked ubiquitination; protein polyubiquitination; protein ubiquitination; regulation of cell cycle; regulation of DNA damage checkpoint; regulation of DNA methylation; regulation of DNA repair; regulation of gene expression by genomic imprinting; regulation of transcription by RNA polymerase II; response to estrogen; response to ionizing radiation; response to stimulus","damaged DNA binding; DNA binding; enzyme binding; identical protein binding; metal ion binding; p53 binding; protein binding; RNA binding; RNA polymerase binding; transcription cis-regulatory region binding; transcription coactivator activity; transferase activity; tubulin binding; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding","BRCA1-A complex; BRCA1-B complex; BRCA1-BARD1 complex; BRCA1-C complex; chromosome; condensed chromosome; condensed nuclear chromosome; cytoplasm; DNA repair complex; gamma-tubulin ring complex; intracellular non-membrane-bounded organelle; lateral element; male germ cell nucleus; nuclear body; nuclear ubiquitin ligase complex; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ribonucleoprotein complex; ubiquitin ligase complex; XY body","DNA damage","BRCA1 DNA repair associated","http://www.ncbi.nlm.nih.gov/gene/?term=672","672","12189",null,null,"100049662",null,"P38398","P48754","A0A0G2K2T3","A0A8I3MRE9","A0A286ZS33","F6PQM4","GO:0070531; GO:0070532; GO:0031436; GO:0070533; GO:0005694; GO:0000793; GO:0000794; GO:0005737; GO:1990391; GO:0000931; GO:0043232; GO:0000800; GO:0001673; GO:0016604; GO:0000152; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:1990904; GO:0000151; GO:0001741","GO:0003684; GO:0003677; GO:0019899; GO:0042802; GO:0046872; GO:0002039; GO:0005515; GO:0003723; GO:0070063; GO:0000976; GO:0003713; GO:0016740; GO:0015631; GO:0031625; GO:0004842; GO:0008270","GO:0007049; GO:0006974; GO:0071681; GO:0071479; GO:0071356; GO:0007098; GO:0043009; GO:0007059; GO:0006310; GO:0006281; GO:0110025; GO:0009048; GO:0006302; GO:0000724; GO:0006633; GO:0006631; GO:0070537; GO:0035518; GO:0035825; GO:0008630; GO:0006629; GO:0051179; GO:0007095; GO:0044818; GO:0045786; GO:0030308; GO:0046600; GO:0045892; GO:1902042; GO:0045717; GO:0035067; GO:0051572; GO:0051573; GO:0033147; GO:2000378; GO:0045766; GO:0045739; GO:0045893; GO:0010628; GO:0035066; GO:0051571; GO:2000617; GO:0051574; GO:2000620; GO:0070512; GO:0031398; GO:0045944; GO:0010575; GO:0006301; GO:0051865; GO:0085020; GO:0000209; GO:0016567; GO:0051726; GO:2000001; GO:0044030; GO:0006282; GO:0006349; GO:0006357; GO:0043627; GO:0010212; GO:0050896","PTHR13763:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1100|UniProtKB=P38398"]
["BRCA2",null,"BRCA2","380","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1264",".APO., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .OP., .OT., .P53S., .PAC., .TRASR., .UBI.",null,"BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN","brain development; cell cycle; cell population proliferation; cellular response to DNA damage stimulus; cellular response to ionizing radiation; cellular senescence; centrosome duplication; chordate embryonic development; chromosome organization; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; establishment of protein localization to telomere; female gonad development; hematopoietic stem cell proliferation; hemopoiesis; histone H2A monoubiquitination; histone H3 acetylation; histone H4 acetylation; inner cell mass cell proliferation; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; male meiosis I; mitotic recombination-dependent replication fork processing; negative regulation of mammary gland epithelial cell proliferation; nucleotide-excision repair; oocyte maturation; positive regulation of DNA-templated transcription; positive regulation of mitotic cell cycle; protein autoubiquitination; regulation of cytokinesis; regulation of DNA damage checkpoint; regulation of DNA-templated transcription; replication fork protection; response to gamma radiation; response to stimulus; response to UV-C; response to X-ray; spermatogenesis; stem cell proliferation; telomere maintenance via recombination","DNA binding; gamma-tubulin binding; histone acetyltransferase activity; histone H3 acetyltransferase activity; histone H4 acetyltransferase activity; identical protein binding; protease binding; protein binding; protein C-terminus binding; single-stranded DNA binding","BRCA2-MAGE-D1 complex; centrosome; chromosome; chromosome, telomeric region; cytoplasm; cytoskeleton; cytosol; DNA repair complex; lateral element; microtubule organizing center; nuclear ubiquitin ligase complex; nucleoplasm; nucleus; protein-containing complex; secretory granule","DNA damage","BRCA2 DNA repair associated","http://www.ncbi.nlm.nih.gov/gene/?term=675","675","12190",null,null,null,null,"P51587","P97929","A0A8I6B500","A0A8P0PCA7","A0A287B8J8","F7ER68","GO:0033593; GO:0005813; GO:0005694; GO:0000781; GO:0005737; GO:0005856; GO:0005829; GO:1990391; GO:0000800; GO:0005815; GO:0000152; GO:0005654; GO:0005634; GO:0032991; GO:0030141","GO:0003677; GO:0043015; GO:0004402; GO:0010484; GO:0010485; GO:0042802; GO:0002020; GO:0005515; GO:0008022; GO:0003697","GO:0007420; GO:0007049; GO:0008283; GO:0006974; GO:0071479; GO:0090398; GO:0051298; GO:0043009; GO:0051276; GO:0006978; GO:0006310; GO:0006281; GO:0006302; GO:0000724; GO:0070200; GO:0008585; GO:0071425; GO:0030097; GO:0035518; GO:0043966; GO:0043967; GO:0001833; GO:0008630; GO:0042771; GO:0007141; GO:1990426; GO:0033600; GO:0006289; GO:0001556; GO:0045893; GO:0045931; GO:0051865; GO:0032465; GO:2000001; GO:0006355; GO:0048478; GO:0010332; GO:0050896; GO:0010225; GO:0010165; GO:0007283; GO:0072089; GO:0000722","PTHR11289:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1101|UniProtKB=P51587"]
["BST2 (Tetherin)",null,"BST2","40-28","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2788",".CCP., .CP., .CSP., .IIR., .IMU., .IMUF., .IMUR., .MIG., .NFKB., .OP., .OT., .VIR.",null,"BONE MARROW STROMAL ANTIGEN 2","B cell activation; defense response to virus; immune system process; innate immune response; negative regulation of cell growth; negative regulation of cell migration; negative regulation of intracellular transport of viral material; negative regulation of plasmacytoid dendritic cell cytokine production; negative regulation of viral genome replication; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of leukocyte proliferation; regulation of actin cytoskeleton organization; response to interferon-alpha; response to interferon-beta; response to type II interferon; response to virus","identical protein binding; metalloendopeptidase inhibitor activity; protein binding; protein homodimerization activity; RNA binding","apical plasma membrane; azurophil granule membrane; cell surface; cytoplasm; endosome; extracellular exosome; Golgi apparatus; intracellular membrane-bounded organelle; late endosome; membrane; membrane raft; multivesicular body; plasma membrane",null,"bone marrow stromal cell antigen 2","http://www.ncbi.nlm.nih.gov/gene/?term=684","684","69550","378947","609654",null,null,"Q10589","Q8R2Q8","Q811A2","J9NVI2",null,"A0A1D5Q5T5","GO:0016324; GO:0035577; GO:0009986; GO:0005737; GO:0005768; GO:0070062; GO:0005794; GO:0043231; GO:0005770; GO:0016020; GO:0045121; GO:0005771; GO:0005886","GO:0042802; GO:0008191; GO:0005515; GO:0042803; GO:0003723","GO:0042113; GO:0051607; GO:0002376; GO:0045087; GO:0030308; GO:0030336; GO:1901253; GO:0002737; GO:0045071; GO:0043123; GO:0070665; GO:0032956; GO:0035455; GO:0035456; GO:0034341; GO:0009615","PTHR15190:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1119|UniProtKB=Q10589"]
["Bub1b",null,"BUB1B","130","rb",null,2,4,4,4,4,4,"# 1033",".APO., .CCP., .CCY., .CD., .CP., .CSP., .OP., .OPA., .OT., .ST., .UBI.",null,"MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 BETA","apoptotic process; cell cycle; cell division; meiotic sister chromatid cohesion, centromeric; metaphase/anaphase transition of mitotic cell cycle; mitotic spindle assembly checkpoint signaling; negative regulation of ubiquitin-protein transferase activity; phosphorylation; protein localization to chromosome, centromeric region","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","anaphase-promoting complex; chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; kinetochore; microtubule organizing center; mitotic checkpoint complex; nucleus; outer kinetochore; perinuclear region of cytoplasm; spindle","Cell cycle control","BUB1 mitotic checkpoint serine/threonine kinase B","http://www.ncbi.nlm.nih.gov/gene/?term=701","701","12236","171576",null,null,null,"O60566","Q9Z1S0","F1LMI1","A0A8P0P0N7",null,"A0A1D5QGI0","GO:0005680; GO:0005694; GO:0000775; GO:0005737; GO:0005856; GO:0005829; GO:0000776; GO:0005815; GO:0033597; GO:0005634; GO:0000940; GO:0048471; GO:0005819","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:0007049; GO:0051301; GO:0051754; GO:0007091; GO:0007094; GO:0051444; GO:0016310; GO:0071459","PTHR14030:SF25","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1149|UniProtKB=O60566"]
["C/EBP alpha",null,"CEBPA","42, 28","rb",null,2.1,1,1,8,8,8,"# 1195",".AML., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .IMFR., .IMUF., .IMUR., .INFM., .NOTCH., .OP., .OPA., .OT., .ST., .TNF., .TRASR.",null,"CCAAT/ENHANCER-BINDING PROTEIN ALPHA","brown fat cell differentiation; cell population proliferation; cellular response to lithium ion; cellular response to organic cyclic compound; cellular response to tumor necrosis factor; cholesterol metabolic process; cytokine-mediated signaling pathway; DNA-templated transcription; embryonic placenta development; epithelial cell maturation; fat cell differentiation; generation of precursor metabolites and energy; glucose homeostasis; granulocyte differentiation; hematopoietic stem cell proliferation; inner ear development; integrated stress response signaling; interleukin-6-mediated signaling pathway; lipid homeostasis; liver development; lung development; macrophage differentiation; mitochondrion organization; myeloid cell differentiation; negative regulation of cell cycle; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-templated transcription; negative regulation of hematopoietic stem cell proliferation; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of macrophage activation; positive regulation of osteoblast differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription by RNA polymerase II; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; urea cycle; white fat cell differentiation","chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; kinase binding; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; STAT family protein binding; transcription cis-regulatory region binding","C/EBP complex; CHOP-C/EBP complex; chromatin; intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex","Transcription factor","CCAAT enhancer binding protein alpha","http://www.ncbi.nlm.nih.gov/gene/?term=1050","1050","12606",null,null,"397307",null,"P49715","P53566",null,null,"F1RNW6",null,"GO:1990647; GO:0036488; GO:0000785; GO:0043231; GO:0005730; GO:0005654; GO:0005634; GO:0090575; GO:0005667","GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0042802; GO:0019900; GO:0005515; GO:0042803; GO:0000978; GO:0061629; GO:0043565; GO:0097677; GO:0000976","GO:0050873; GO:0008283; GO:0071285; GO:0071407; GO:0071356; GO:0008203; GO:0019221; GO:0006351; GO:0001892; GO:0002070; GO:0045444; GO:0006091; GO:0042593; GO:0030851; GO:0071425; GO:0048839; GO:0140467; GO:0070102; GO:0055088; GO:0001889; GO:0030324; GO:0030225; GO:0007005; GO:0030099; GO:0045786; GO:0008285; GO:0045736; GO:0045892; GO:1902034; GO:0000122; GO:0007219; GO:0045893; GO:0045600; GO:0010628; GO:0050729; GO:0043032; GO:0045669; GO:0032436; GO:0045944; GO:0042127; GO:0006355; GO:0006357; GO:0000050; GO:0050872","PTHR23334:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1833|UniProtKB=P49715"]
["C/EBP alpha - phospho","Thr222/Thr226","CEBPA","45, 42, 30","rb",null,6,2.1,4,4,4,4,"# 1175",".AML., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .IMFR., .IMUF., .IMUR., .INFM., .NOTCH., .OP., .OPA., .OT., .ST., .TNF., .TRASR.",null,"CCAAT/ENHANCER-BINDING PROTEIN ALPHA","brown fat cell differentiation; cell population proliferation; cellular response to lithium ion; cellular response to organic cyclic compound; cellular response to tumor necrosis factor; cholesterol metabolic process; cytokine-mediated signaling pathway; DNA-templated transcription; embryonic placenta development; epithelial cell maturation; fat cell differentiation; generation of precursor metabolites and energy; glucose homeostasis; granulocyte differentiation; hematopoietic stem cell proliferation; inner ear development; integrated stress response signaling; interleukin-6-mediated signaling pathway; lipid homeostasis; liver development; lung development; macrophage differentiation; mitochondrion organization; myeloid cell differentiation; negative regulation of cell cycle; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-templated transcription; negative regulation of hematopoietic stem cell proliferation; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of macrophage activation; positive regulation of osteoblast differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription by RNA polymerase II; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; urea cycle; white fat cell differentiation","chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; kinase binding; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; STAT family protein binding; transcription cis-regulatory region binding","C/EBP complex; CHOP-C/EBP complex; chromatin; intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex","Transcription factor","CCAAT enhancer binding protein alpha","http://www.ncbi.nlm.nih.gov/gene/?term=1050","1050","12606",null,null,"397307",null,"P49715","P53566",null,null,"F1RNW6",null,"GO:1990647; GO:0036488; GO:0000785; GO:0043231; GO:0005730; GO:0005654; GO:0005634; GO:0090575; GO:0005667","GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0042802; GO:0019900; GO:0005515; GO:0042803; GO:0000978; GO:0061629; GO:0043565; GO:0097677; GO:0000976","GO:0050873; GO:0008283; GO:0071285; GO:0071407; GO:0071356; GO:0008203; GO:0019221; GO:0006351; GO:0001892; GO:0002070; GO:0045444; GO:0006091; GO:0042593; GO:0030851; GO:0071425; GO:0048839; GO:0140467; GO:0070102; GO:0055088; GO:0001889; GO:0030324; GO:0030225; GO:0007005; GO:0030099; GO:0045786; GO:0008285; GO:0045736; GO:0045892; GO:1902034; GO:0000122; GO:0007219; GO:0045893; GO:0045600; GO:0010628; GO:0050729; GO:0043032; GO:0045669; GO:0032436; GO:0045944; GO:0042127; GO:0006355; GO:0006357; GO:0000050; GO:0050872","PTHR23334:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1833|UniProtKB=P49715"]
["C/EBP beta",null,"CEBPB","49-45 (human, LAP), 38-35 (mouse, LAP)","rb",null,2,2,2,8,2,8,"# 1179",".APO., .CCP., .CD., .CP., .CSP., .IMFR., .IMU., .IMUR., .OP., .OT., .TNF., .TRASR.",null,"CCAAT/ENHANCER-BINDING PROTEIN BETA","acute-phase response; brown fat cell differentiation; cell differentiation; cellular response to amino acid stimulus; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to organic cyclic compound; defense response to bacterium; DNA-templated transcription; embryonic placenta development; fat cell differentiation; hepatocyte proliferation; immune response; inflammatory response; integrated stress response signaling; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; liver development; liver regeneration; mammary gland epithelial cell differentiation; mammary gland epithelial cell proliferation; memory; myeloid cell development; negative regulation of DNA-templated transcription; negative regulation of neuron apoptotic process; negative regulation of T cell proliferation; negative regulation of transcription by RNA polymerase II; neuron differentiation; ovarian follicle development; positive regulation of biomineral tissue development; positive regulation of cold-induced thermogenesis; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of interleukin-4 production; positive regulation of osteoblast differentiation; positive regulation of sodium-dependent phosphate transport; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; regulation of cell differentiation; regulation of dendritic cell differentiation; regulation of DNA-templated transcription; regulation of interleukin-6 production; regulation of odontoblast differentiation; regulation of osteoclast differentiation; regulation of transcription by RNA polymerase II; response to endoplasmic reticulum stress; response to lipopolysaccharide; transcription by RNA polymerase II","chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone acetyltransferase binding; histone deacetylase binding; identical protein binding; kinase binding; nuclear glucocorticoid receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; ubiquitin-like protein ligase binding","C/EBP complex; CHOP-C/EBP complex; chromatin; condensed chromosome, centromeric region; cytoplasm; nuclear matrix; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Transcription factor","CCAAT enhancer binding protein beta","http://www.ncbi.nlm.nih.gov/gene/?term=1051","1051","12608",null,"100856480",null,"713191","P17676","P28033","A0A8L2R490","A0A8I3Q8Y2",null,"I2CUK0","GO:1990647; GO:0036488; GO:0000785; GO:0000779; GO:0005737; GO:0016363; GO:0005654; GO:0005634; GO:0090575","GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0035035; GO:0042826; GO:0042802; GO:0019900; GO:0035259; GO:0005515; GO:0046982; GO:0042803; GO:0000978; GO:0000979; GO:0000977; GO:0061629; GO:0043565; GO:1990837; GO:0000976; GO:0044389","GO:0006953; GO:0050873; GO:0030154; GO:0071230; GO:0071347; GO:0071222; GO:0071407; GO:0042742; GO:0006351; GO:0001892; GO:0045444; GO:0072574; GO:0006955; GO:0006954; GO:0140467; GO:0070059; GO:0001889; GO:0097421; GO:0060644; GO:0033598; GO:0007613; GO:0061515; GO:0045892; GO:0043524; GO:0042130; GO:0000122; GO:0030182; GO:0001541; GO:0070169; GO:0120162; GO:0045893; GO:0045600; GO:0010628; GO:0050729; GO:0032753; GO:0045669; GO:2000120; GO:0045944; GO:1990440; GO:0045595; GO:2001198; GO:0006355; GO:0032675; GO:1901329; GO:0045670; GO:0006357; GO:0034976; GO:0032496; GO:0006366","PTHR23334:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1834|UniProtKB=P17676"]
["C/EBP beta - phospho","Thr235","CEBPB","38, 36 (LAP); 19 (LIP)","rb",null,2.1,4,4,4,4,4,"# 1183",".APO., .CCP., .CD., .CP., .CSP., .IMFR., .IMU., .IMUR., .OP., .OT., .TNF., .TRASR.",null,"CCAAT/ENHANCER-BINDING PROTEIN BETA","acute-phase response; brown fat cell differentiation; cell differentiation; cellular response to amino acid stimulus; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to organic cyclic compound; defense response to bacterium; DNA-templated transcription; embryonic placenta development; fat cell differentiation; hepatocyte proliferation; immune response; inflammatory response; integrated stress response signaling; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; liver development; liver regeneration; mammary gland epithelial cell differentiation; mammary gland epithelial cell proliferation; memory; myeloid cell development; negative regulation of DNA-templated transcription; negative regulation of neuron apoptotic process; negative regulation of T cell proliferation; negative regulation of transcription by RNA polymerase II; neuron differentiation; ovarian follicle development; positive regulation of biomineral tissue development; positive regulation of cold-induced thermogenesis; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of interleukin-4 production; positive regulation of osteoblast differentiation; positive regulation of sodium-dependent phosphate transport; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; regulation of cell differentiation; regulation of dendritic cell differentiation; regulation of DNA-templated transcription; regulation of interleukin-6 production; regulation of odontoblast differentiation; regulation of osteoclast differentiation; regulation of transcription by RNA polymerase II; response to endoplasmic reticulum stress; response to lipopolysaccharide; transcription by RNA polymerase II","chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone acetyltransferase binding; histone deacetylase binding; identical protein binding; kinase binding; nuclear glucocorticoid receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; ubiquitin-like protein ligase binding","C/EBP complex; CHOP-C/EBP complex; chromatin; condensed chromosome, centromeric region; cytoplasm; nuclear matrix; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Transcription factor","CCAAT enhancer binding protein beta","http://www.ncbi.nlm.nih.gov/gene/?term=1051","1051","12608",null,"100856480",null,"713191","P17676","P28033","A0A8L2R490","A0A8I3Q8Y2",null,"I2CUK0","GO:1990647; GO:0036488; GO:0000785; GO:0000779; GO:0005737; GO:0016363; GO:0005654; GO:0005634; GO:0090575","GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0035035; GO:0042826; GO:0042802; GO:0019900; GO:0035259; GO:0005515; GO:0046982; GO:0042803; GO:0000978; GO:0000979; GO:0000977; GO:0061629; GO:0043565; GO:1990837; GO:0000976; GO:0044389","GO:0006953; GO:0050873; GO:0030154; GO:0071230; GO:0071347; GO:0071222; GO:0071407; GO:0042742; GO:0006351; GO:0001892; GO:0045444; GO:0072574; GO:0006955; GO:0006954; GO:0140467; GO:0070059; GO:0001889; GO:0097421; GO:0060644; GO:0033598; GO:0007613; GO:0061515; GO:0045892; GO:0043524; GO:0042130; GO:0000122; GO:0030182; GO:0001541; GO:0070169; GO:0120162; GO:0045893; GO:0045600; GO:0010628; GO:0050729; GO:0032753; GO:0045669; GO:2000120; GO:0045944; GO:1990440; GO:0045595; GO:2001198; GO:0006355; GO:0032675; GO:1901329; GO:0045670; GO:0006357; GO:0034976; GO:0032496; GO:0006366","PTHR23334:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1834|UniProtKB=P17676"]
["C5",null,"C5","188","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1674",".ANG., .CANCER., .CSP., .GPCR., .GPROT., .IIR., .IMFR., .IMU., .IMUR., .LMIG., .MIG., .OP., .OPA., .OT., .ST., .TRASR.",null,"COMPLEMENT C5","cell chemotaxis; cell surface receptor signaling pathway; chemotaxis; complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; G protein-coupled receptor signaling pathway; immune response; immune system process; in utero embryonic development; inflammatory response; innate immune response; negative regulation of macrophage chemotaxis; positive regulation of angiogenesis; positive regulation of chemokine production; positive regulation of response to stimulus; positive regulation of vascular endothelial growth factor production","chemokine activity; endopeptidase inhibitor activity; protein binding; signaling receptor binding","extracellular exosome; extracellular region; extracellular space; membrane attack complex",null,"complement C5","http://www.ncbi.nlm.nih.gov/gene/?term=727","727","15139",null,null,null,null,"P01031","P06684","A0A8I5ZDN9","A0A8P0S986","A0A286ZKB4","F7GHV1","GO:0070062; GO:0005576; GO:0005615; GO:0005579","GO:0008009; GO:0004866; GO:0005515; GO:0005102","GO:0060326; GO:0007166; GO:0006935; GO:0006956; GO:0006957; GO:0006958; GO:0019835; GO:0007186; GO:0006955; GO:0002376; GO:0001701; GO:0006954; GO:0045087; GO:0010760; GO:0045766; GO:0032722; GO:0048584; GO:0010575","PTHR11412:SF83","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1331|UniProtKB=P01031"]
["CA IX (CA9)",null,"CA9","58-35","rb",null,6,6,8,8,8,1,"# 0896",".CSP., .DRR., .HIF., .OP., .OT., .SREME.",null,"CARBONIC ANHYDRASE 9","morphogenesis of an epithelium; one-carbon metabolic process; response to hypoxia; response to testosterone; response to xenobiotic stimulus; secretion","carbonate dehydratase activity; hydro-lyase activity; lyase activity; metal ion binding; molecular function activator activity; protein binding; zinc ion binding","basolateral plasma membrane; cell projection; membrane; microvillus membrane; nucleolus; nucleus; plasma membrane",null,"carbonic anhydrase 9","http://www.ncbi.nlm.nih.gov/gene/?term=768","768","230099","313495","611933",null,null,"Q16790","Q8VHB5","F7FL00","A0A8I3NCN1",null,null,"GO:0016323; GO:0042995; GO:0016020; GO:0031528; GO:0005730; GO:0005634; GO:0005886","GO:0004089; GO:0016836; GO:0016829; GO:0046872; GO:0140677; GO:0005515; GO:0008270","GO:0002009; GO:0006730; GO:0001666; GO:0033574; GO:0009410; GO:0046903","PTHR18952:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1383|UniProtKB=Q16790"]
["CA125 (MUC16)",null,"MUC16","1519","ms",null,7,4,"n/a","n/a","n/a","n/a","# 1636",null,null,"MUCIN-16","cell adhesion","protein binding","extracellular exosome; extracellular region; extracellular space; extrinsic component of membrane; Golgi lumen; membrane; plasma membrane; vesicle","Tumor marker","mucin 16, cell surface associated","http://www.ncbi.nlm.nih.gov/gene/?term=94025","94025",null,null,null,null,null,"Q8WXI7","A0A140LI05",null,null,"F1S2M2",null,"GO:0070062; GO:0005576; GO:0005615; GO:0019898; GO:0005796; GO:0016020; GO:0005886; GO:0031982","GO:0005515","GO:0007155","PTHR14672:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=15582|UniProtKB=Q8WXI7"]
["Calcineurin B",null,"PPP3R1","19","ms",null,2,2.1,4,4,4,4,"# 2439",".ALZ., .ANG., .BCR., .CANCER., .CSP., .DEV., .DI., .IMUF., .MAPK., .OP., .OPA., .OT., .RTK., .ST., .TCD., .TCR., .TMAT., .TRASR., .VEGFS., .WNT.","Wnt signaling pathway","CALCINEURIN SUBUNIT B TYPE 1","branching involved in blood vessel morphogenesis; calcineurin-mediated signaling; calcineurin-NFAT signaling cascade; epithelial to mesenchymal transition; heart development; lung epithelial cell differentiation; myelination in peripheral nervous system; negative regulation of calcium ion import across plasma membrane; negative regulation of voltage-gated calcium channel activity; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of calcium ion import across plasma membrane; positive regulation of transcription by RNA polymerase II; positive regulation of voltage-gated calcium channel activity; postsynaptic modulation of chemical synaptic transmission; protein dephosphorylation; protein import into nucleus; protein localization to nucleus; regulation of postsynaptic neurotransmitter receptor internalization; regulation of synaptic vesicle cycle; Schwann cell development","calcium ion binding; calcium-dependent protein serine/threonine phosphatase activity; calcium-dependent protein serine/threonine phosphatase regulator activity; calmodulin binding; cyclosporin A binding; metal ion binding; phosphatase binding; phosphoprotein phosphatase activity; protein binding; protein domain specific binding","calcineurin complex; cytoplasm; cytosol; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; membrane; nucleoplasm; parallel fiber to Purkinje cell synapse; plasma membrane; postsynapse; protein serine/threonine phosphatase complex; sarcolemma; Schaffer collateral - CA1 synapse; synapse",null,"protein phosphatase 3 regulatory subunit B, alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5534","5534","19058",null,null,null,null,"P63098","Q63810",null,null,null,"A0A1D5RKL0","GO:0005955; GO:0005737; GO:0005829; GO:0098978; GO:0098686; GO:0016020; GO:0005654; GO:0098688; GO:0005886; GO:0098794; GO:0008287; GO:0042383; GO:0098685; GO:0045202","GO:0005509; GO:0004723; GO:0008597; GO:0005516; GO:0016018; GO:0046872; GO:0019902; GO:0004721; GO:0005515; GO:0019904","GO:0001569; GO:0097720; GO:0033173; GO:0001837; GO:0007507; GO:0060487; GO:0022011; GO:1905949; GO:1901386; GO:0070886; GO:1905665; GO:0045944; GO:1901387; GO:0099170; GO:0006470; GO:0006606; GO:0034504; GO:0099149; GO:0098693; GO:0014044","PTHR45942:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9317|UniProtKB=P63098","P00057"]
["Calmodulin",null,"CALM2","17","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0540",".ALZ., .BCR., .cAMP., .CANCER., .CANPTHW., .CCP., .CCY., .CSP., .DI., .GLI., .GPCR., .GPROT., .IMUF., .INS., .OP., .OPA., .RAS., .RTK., .SREME., .ST., .TCR.","T cell activation; Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction; B cell activation; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway","CALMODULIN-2","detection of calcium ion; G protein-coupled receptor signaling pathway; G2/M transition of mitotic cell cycle; negative regulation of calcium ion export across plasma membrane; negative regulation of calcium ion transmembrane transporter activity; negative regulation of peptidyl-threonine phosphorylation; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of DNA binding; positive regulation of peptidyl-threonine phosphorylation; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein autophosphorylation; positive regulation of protein dephosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of ryanodine-sensitive calcium-release channel activity; regulation of calcium-mediated signaling; regulation of cardiac muscle contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of cytokinesis; regulation of heart rate; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; response to calcium ion; substantia nigra development","adenylate cyclase activator activity; adenylate cyclase binding; calcium channel inhibitor activity; calcium ion binding; calcium-dependent protein binding; disordered domain specific binding; enzyme regulator activity; metal ion binding; N-terminal myristoylation domain binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase activator activity; protein serine/threonine kinase activator activity; titin binding; transmembrane transporter binding","calcium channel complex; catalytic complex; centrosome; cytoplasm; cytoskeleton; membrane; microtubule organizing center; myelin sheath; nucleus; plasma membrane; protein-containing complex; sarcomere; sperm midpiece; spindle; spindle microtubule; spindle pole; vesicle; voltage-gated potassium channel complex",null,"calmodulin 2","http://www.ncbi.nlm.nih.gov/gene/?term=801","801",null,null,null,null,null,"P0DP24",null,null,null,null,"A0A5F7ZB25","GO:0034704; GO:1902494; GO:0005813; GO:0005737; GO:0005856; GO:0016020; GO:0005815; GO:0043209; GO:0005634; GO:0005886; GO:0032991; GO:0030017; GO:0097225; GO:0005819; GO:0005876; GO:0000922; GO:0031982; GO:0008076","GO:0010856; GO:0008179; GO:0019855; GO:0005509; GO:0048306; GO:0097718; GO:0030234; GO:0046872; GO:0031997; GO:0005515; GO:0019904; GO:0019901; GO:0072542; GO:0043539; GO:0031432; GO:0044325","GO:0005513; GO:0007186; GO:0000086; GO:1905913; GO:1901020; GO:0010801; GO:0060315; GO:0051343; GO:0043388; GO:0010800; GO:0032516; GO:0031954; GO:0035307; GO:0071902; GO:0060316; GO:0050848; GO:0055117; GO:0010881; GO:1901844; GO:0032465; GO:0002027; GO:0010880; GO:0060314; GO:0051592; GO:0021762","PTHR23050:SF383","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1445|UniProtKB=P0DP24","P00053; P00028; P00010; P00026"]
["Calnexin",null,"CANX","90","ms",null,1,1,1.1000000000000001,8,1,8,"# 0510",".IMUR., .OP., .VIR.",null,"CALNEXIN","aging; clathrin-dependent endocytosis; protein folding; protein folding in endoplasmic reticulum; protein secretion; synaptic vesicle endocytosis; ubiquitin-dependent ERAD pathway; viral protein processing","apolipoprotein binding; calcium ion binding; carbohydrate binding; ionotropic glutamate receptor binding; metal ion binding; protein binding; RNA binding; unfolded protein binding","axon; cytoplasm; dendrite cytoplasm; dendritic spine; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; extracellular exosome; glutamatergic synapse; lumenal side of endoplasmic reticulum membrane; melanosome; membrane; mitochondria-associated endoplasmic reticulum membrane; neuronal cell body; nuclear membrane; postsynaptic membrane; presynaptic active zone membrane; protein-containing complex; ribosome; rough endoplasmic reticulum; smooth endoplasmic reticulum","Translational control / RNA regulation","calnexin","http://www.ncbi.nlm.nih.gov/gene/?term=821","821","12330",null,null,null,null,"P27824","P35564","A0A8L2QK91","A0A8I3NJ48","A0A286ZLE4","A0A1D5Q8G1","GO:0030424; GO:0005737; GO:0032839; GO:0043197; GO:0005783; GO:0005788; GO:0005789; GO:0044322; GO:0070062; GO:0098978; GO:0098553; GO:0042470; GO:0016020; GO:0044233; GO:0043025; GO:0031965; GO:0045211; GO:0048787; GO:0032991; GO:0005840; GO:0005791; GO:0005790","GO:0034185; GO:0005509; GO:0030246; GO:0035255; GO:0046872; GO:0005515; GO:0003723; GO:0051082","GO:0007568; GO:0072583; GO:0006457; GO:0034975; GO:0009306; GO:0048488; GO:0030433; GO:0019082","PTHR11073:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1473|UniProtKB=P27824"]
["Calreticulin",null,"CALR","55","rb",null,1,1,1,1,1,1,"# 0429",".APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .DRR., .IMUF., .IMUR., .LMIG., .MIG., .NFKB., .OP., .OPA., .OT., .ST., .TRASR., .VIR.",null,"CALRETICULIN","cardiac muscle cell differentiation; cellular calcium ion homeostasis; cellular response to electrical stimulus; cellular response to lithium ion; cellular response to organic substance; cellular response to virus; cellular senescence; cortical actin cytoskeleton organization; glucocorticoid receptor signaling pathway; negative regulation of DNA-templated transcription; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of translation; negative regulation of trophoblast cell migration; peptide antigen assembly with MHC class I protein complex; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of dendritic cell chemotaxis; positive regulation of endothelial cell migration; positive regulation of gene expression; positive regulation of NIK/NF-kappaB signaling; positive regulation of phagocytosis; positive regulation of substrate adhesion-dependent cell spreading; protein export from nucleus; protein folding; protein folding in endoplasmic reticulum; protein localization to nucleus; protein maturation by protein folding; protein stabilization; regulation of apoptotic process; regulation of DNA-templated transcription; regulation of meiotic nuclear division; response to estradiol; response to glycoside; response to organic substance; response to testosterone; response to xenobiotic stimulus; selective autophagy; sequestering of calcium ion; spermatogenesis; ubiquitin-dependent ERAD pathway","calcium ion binding; carbohydrate binding; chaperone binding; complement component C1q complex binding; DNA binding; hormone binding; integrin binding; iron ion binding; metal ion binding; mRNA binding; nuclear androgen receptor binding; peptide binding; protein binding; protein folding chaperone; RNA binding; ubiquitin protein ligase binding; unfolded protein binding; zinc ion binding","acrosomal vesicle; cell surface; collagen-containing extracellular matrix; cortical granule; cytolytic granule; cytoplasm; cytoplasmic vesicle; cytosol; endocytic vesicle lumen; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; focal adhesion; Golgi apparatus; intracellular membrane-bounded organelle; lumenal side of endoplasmic reticulum membrane; lysosome; membrane; MHC class I peptide loading complex; nuclear envelope; nucleus; perinuclear region of cytoplasm; phagocytic vesicle membrane; plasma membrane; polysome; protein-containing complex; sarcoplasmic reticulum; sarcoplasmic reticulum lumen; smooth endoplasmic reticulum","Translational control / RNA regulation","calreticulin","http://www.ncbi.nlm.nih.gov/gene/?term=811","811","12317","64202",null,"100381266","716910","P27797","P14211","P18418","A0A8I3NM03","P28491","G7NLC3","GO:0001669; GO:0009986; GO:0062023; GO:0060473; GO:0044194; GO:0005737; GO:0031410; GO:0005829; GO:0071682; GO:0005783; GO:0005788; GO:0005789; GO:0044322; GO:0033116; GO:0009897; GO:0070062; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0043231; GO:0098553; GO:0005764; GO:0016020; GO:0042824; GO:0005635; GO:0005634; GO:0048471; GO:0030670; GO:0005886; GO:0005844; GO:0032991; GO:0016529; GO:0033018; GO:0005790","GO:0005509; GO:0030246; GO:0051087; GO:0001849; GO:0003677; GO:0042562; GO:0005178; GO:0005506; GO:0046872; GO:0003729; GO:0050681; GO:0042277; GO:0005515; GO:0044183; GO:0003723; GO:0031625; GO:0051082; GO:0008270","GO:0055007; GO:0006874; GO:0071257; GO:0071285; GO:0071310; GO:0098586; GO:0090398; GO:0030866; GO:0042921; GO:0045892; GO:0033144; GO:0045665; GO:0048387; GO:0000122; GO:0017148; GO:1901164; GO:0002502; GO:0045787; GO:0008284; GO:2000510; GO:0010595; GO:0010628; GO:1901224; GO:0050766; GO:1900026; GO:0006611; GO:0006457; GO:0034975; GO:0034504; GO:0022417; GO:0050821; GO:0042981; GO:0006355; GO:0040020; GO:0032355; GO:1903416; GO:0010033; GO:0033574; GO:0009410; GO:0061912; GO:0051208; GO:0007283; GO:0030433","PTHR11073:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1455|UniProtKB=P27797"]
["Calretinin",null,"CALB2","29","ms",null,4,1,"n/a","n/a","n/a","n/a","# 0505",null,null,"CALRETININ","regulation of cytosolic calcium ion concentration; regulation of long-term synaptic potentiation; regulation of presynaptic cytosolic calcium ion concentration","calcium ion binding; calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration; metal ion binding","cytosol; dendrite; gap junction; neuron projection; nucleus; parallel fiber to Purkinje cell synapse; synapse; terminal bouton","Translational control / RNA regulation","calbindin 2","http://www.ncbi.nlm.nih.gov/gene/?term=794","794","12308","117059",null,null,null,"P22676","Q08331","P47728","A0A8I3MZN0","A0A287AGT1","A0A5F7ZSK8","GO:0005829; GO:0030425; GO:0005921; GO:0043005; GO:0005634; GO:0098688; GO:0045202; GO:0043195","GO:0005509; GO:0099534; GO:0046872","GO:0051480; GO:1900271; GO:0099509","PTHR19972:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1435|UniProtKB=P22676"]
["CaMK IV",null,"CAMK4","60","ms",null,7,4,"n/a","n/a","n/a","n/a","# 0506",".cAMP., .CANCER., .CCKR., .CSP., .GLI., .GPCR., .IMFR., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .ST., .TCD., .TCR., .TMAT., .TRASR.","CCKR signaling map","CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV","adaptive immune response; immune system process; inflammatory response; intracellular signal transduction; long-term memory; myeloid dendritic cell differentiation; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of myeloid dendritic cell cytokine production; protein autophosphorylation; protein phosphorylation; regulation of osteoclast differentiation; regulation of T cell differentiation in thymus; signal transduction","ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; extracellular exosome; fibrillar center; glutamatergic synapse; nucleoplasm; nucleus; postsynapse","Calcium signaling","calcium/calmodulin dependent protein kinase IV","http://www.ncbi.nlm.nih.gov/gene/?term=814","814",null,"25050",null,null,null,"Q16566","A0A3Q4EG96","P13234",null,null,"A0A5F7ZQ49","GO:0005737; GO:0070062; GO:0001650; GO:0098978; GO:0005654; GO:0005634; GO:0098794","GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0016301; GO:0000166; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0002250; GO:0002376; GO:0006954; GO:0035556; GO:0007616; GO:0043011; GO:0018105; GO:0016310; GO:0045893; GO:0002735; GO:0046777; GO:0006468; GO:0045670; GO:0033081; GO:0007165","PTHR24349:SF338","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1464|UniProtKB=Q16566","P06959"]
["CaMKII (pan)",null,"CAMK2G","60, 50","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2186",".cAMP., .CANCER., .CANPTHW., .CSP., .DEV., .EGFR., .GLI., .GPCR., .HIF., .IMUF., .INFM., .OP., .OPA., .RTK., .SREME., .ST., .WNT.","Ionotropic glutamate receptor pathway; Inflammation mediated by chemokine and cytokine signaling pathway","CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA","cell differentiation; insulin secretion; nervous system development; phosphorylation; protein phosphorylation; regulation of calcium ion transport; regulation of neuron projection development; regulation of skeletal muscle adaptation","ATP binding; calcium-dependent protein serine/threonine phosphatase activity; calmodulin binding; calmodulin-dependent protein kinase activity; identical protein binding; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","calcium- and calmodulin-dependent protein kinase complex; cellular anatomical entity; cytoplasm; cytosol; endocytic vesicle membrane; membrane; neuron projection; nucleoplasm; sarcoplasmic reticulum; sarcoplasmic reticulum membrane",null,"calcium/calmodulin dependent protein kinase II gamma","http://www.ncbi.nlm.nih.gov/gene/?term=818","818","12325","171140","","","","Q9UQM7 , Q13554 , Q13557 , Q13555","Q923T9","P11730","A0A8I3N545","A0A286ZKT1","A0A1D5Q485","GO:0005954; GO:0110165; GO:0005737; GO:0005829; GO:0030666; GO:0016020; GO:0043005; GO:0005654; GO:0016529; GO:0033017","GO:0005524; GO:0004723; GO:0005516; GO:0004683; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0030154; GO:0030073; GO:0007399; GO:0016310; GO:0006468; GO:0051924; GO:0010975; GO:0014733","PTHR24347:SF398","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1463|UniProtKB=Q13555","P00037; P00031"]
["Canceroembryogenic antigen (CEA)",null,"CEACAM5","200-180","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0481",".APO., .CD., .CSP.",null,"CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED","apoptotic process; cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; homotypic cell-cell adhesion; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of myotube differentiation","GPI anchor binding; identical protein binding; protein binding; protein homodimerization activity","apical plasma membrane; basolateral plasma membrane; cell surface; extracellular exosome; extracellular region; membrane; plasma membrane","Cytoskeletal regulation / Adhesion","CEA cell adhesion molecule 5","http://www.ncbi.nlm.nih.gov/gene/?term=1048","1048","26367","81613",null,null,"708398","P06731","Q925P2","P16573","A0A8I3MF26","M3TYM6","F6YVW1","GO:0016324; GO:0016323; GO:0009986; GO:0070062; GO:0005576; GO:0016020; GO:0005886","GO:0034235; GO:0042802; GO:0005515; GO:0042803","GO:0006915; GO:0007155; GO:0007157; GO:0007156; GO:0034109; GO:2000811; GO:0043066; GO:0010832","PTHR44337:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1817|UniProtKB=P06731"]
["CAPG",null,"CAPG","38","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1643",".CD., .CSP., .FAS.","FAS signaling pathway","MACROPHAGE-CAPPING PROTEIN","actin filament capping; actin filament severing; actin polymerization or depolymerization; barbed-end actin filament capping; cell projection assembly; central nervous system development; extracellular matrix disassembly; positive regulation of podosome assembly; protein-containing complex assembly","actin binding; actin filament binding; cadherin binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein domain specific binding; protein-containing complex binding","actin cytoskeleton; cell projection; centriole; cytoplasm; extracellular exosome; extracellular space; F-actin capping protein complex; Flemming body; lamellipodium; melanosome; mitotic spindle; nucleolus; nucleoplasm; nucleus; ruffle",null,"capping actin protein, gelsolin like","http://www.ncbi.nlm.nih.gov/gene/?term=822","822",null,"297339",null,null,null,"P40121","D3YTL5","Q6AYC4","A0A8P0NZM5","A0A287B091","A0A5F7ZRF2","GO:0015629; GO:0042995; GO:0005814; GO:0005737; GO:0070062; GO:0005615; GO:0008290; GO:0090543; GO:0030027; GO:0042470; GO:0072686; GO:0005730; GO:0005654; GO:0005634; GO:0001726","GO:0003779; GO:0051015; GO:0045296; GO:0005546; GO:0005515; GO:0019904; GO:0044877","GO:0051693; GO:0051014; GO:0008154; GO:0051016; GO:0030031; GO:0007417; GO:0022617; GO:0071803; GO:0065003","PTHR11977:SF127","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1474|UniProtKB=P40121","P00020"]
["Caseinkinase 1 alpha",null,"CSNK1A1","34","rb",null,1,1,1,8,4,4,"TK # 035",".ALZ., .BRC., .CANCER., .CCKR., .CCP., .CCY., .CP., .CSP., .DEV., .DI., .HHSP., .IMUR., .OP., .OPA., .PARK., .ST., .VIR., .WNT.","CCKR signaling map; Hedgehog signaling pathway; Parkinson disease; Wnt signaling pathway","CASEIN KINASE I ISOFORM ALPHA","cell cycle; cell division; cell surface receptor signaling pathway; Golgi organization; intermediate filament cytoskeleton organization; negative regulation of canonical Wnt signaling pathway; negative regulation of NLRP3 inflammasome complex assembly; peptidyl-serine phosphorylation; phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein phosphorylation; regulation of GTP binding; signal transduction; viral protein processing; Wnt signaling pathway","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","beta-catenin destruction complex; cell projection; centrosome; chromosome; chromosome, centromeric region; ciliary basal body; cilium; cytoplasm; cytoskeleton; cytosol; keratin filament; kinetochore; membrane; microtubule organizing center; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck; nucleus; spindle","Wnt / hedgehog signaling","casein kinase 1 alpha 1","http://www.ncbi.nlm.nih.gov/gene/?term=1452","1452",null,null,null,null,null,"P48729",null,null,"A0A8I3N1B5",null,"A0A1D5QE55","GO:0030877; GO:0042995; GO:0005813; GO:0005694; GO:0000775; GO:0036064; GO:0005929; GO:0005737; GO:0005856; GO:0005829; GO:0045095; GO:0000776; GO:0016020; GO:0005815; GO:0005847; GO:0016607; GO:0005634; GO:0005819","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0051301; GO:0007166; GO:0007030; GO:0045104; GO:0090090; GO:1900226; GO:0018105; GO:0016310; GO:0032436; GO:0043161; GO:0006468; GO:1904424; GO:0007165; GO:0019082; GO:0016055","PTHR11909:SF84","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2451|UniProtKB=P48729","P06959; P00025; P00049; P00057"]
["Caseinkinase 1 delta",null,"CSNK1D","47","ms",null,2,1,2,7,3,3,"# 0719",".CCKR., .CSP., .DEV., .DI., .HHSP., .HIPPO., .OP., .OPA., .OT., .PARK., .ST., .TRASR., .WNT.","CCKR signaling map; Circadian clock system; Parkinson disease; Wnt signaling pathway","CASEIN KINASE I ISOFORM DELTA","cellular response to nerve growth factor stimulus; circadian regulation of gene expression; COPII vesicle coating; Golgi organization; microtubule nucleation; non-motile cilium assembly; peptidyl-serine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of non-canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein phosphorylation; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; protein localization to centrosome; protein localization to cilium; protein localization to Golgi apparatus; protein phosphorylation; regulation of circadian rhythm; rhythmic process; signal transduction; spindle assembly; Wnt signaling pathway","ATP binding; cadherin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; transferase activity","centrosome; ciliary basal body; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi apparatus; membrane; microtubule organizing center; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; spindle; spindle microtubule","Wnt / hedgehog signaling","casein kinase 1 delta","http://www.ncbi.nlm.nih.gov/gene/?term=1453","1453","104318","64462",null,null,null,"P48730","Q9DC28","Q06486","A0A8I3MZY0",null,"A0A5F7ZH13","GO:0005813; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0033116; GO:0005794; GO:0016020; GO:0005815; GO:0043005; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0005819; GO:0005876","GO:0005524; GO:0045296; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0050321; GO:0016740","GO:1990090; GO:0032922; GO:0048208; GO:0007030; GO:0007020; GO:1905515; GO:0018105; GO:0016310; GO:0090263; GO:2000052; GO:0032436; GO:0001934; GO:1905426; GO:0071539; GO:0061512; GO:0034067; GO:0006468; GO:0042752; GO:0048511; GO:0007165; GO:0051225; GO:0016055","PTHR11909:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2452|UniProtKB=P48730","P06959; P00015; P00049; P00057"]
["Caseinkinase 1 epsilon",null,"CSNK1E","47","rb",null,2,6,2,2,2.1,2.1,"# 0340",".ALZ., .CCKR., .CD., .CSP., .DDR., .DEV., .DI., .DREP., .FOXO., .HHSP., .HIPPO., .OP., .OPA., .OT., .PARK., .ST., .TRASR., .WNT.","CCKR signaling map; Circadian clock system; Hedgehog signaling pathway; Parkinson disease; Wnt signaling pathway","CASEIN KINASE I ISOFORM EPSILON","canonical Wnt signaling pathway; cellular response to nerve growth factor stimulus; circadian behavior; circadian regulation of gene expression; DNA repair; endocytosis; negative regulation of protein binding; negative regulation of Wnt signaling pathway; peptidyl-serine phosphorylation; phosphorylation; positive regulation of amyloid-beta formation; positive regulation of canonical Wnt signaling pathway; positive regulation of non-canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of Wnt signaling pathway; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; protein localization; protein phosphorylation; regulation of circadian rhythm; regulation of protein localization; rhythmic process; signal transduction","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA binding; transferase activity","cytoplasm; cytosol; growth cone; neuron projection; neuronal cell body; nucleoplasm; nucleus; ribonucleoprotein complex","Wnt / hedgehog signaling","casein kinase 1 epsilon","http://www.ncbi.nlm.nih.gov/gene/?term=102800317","102800317","27373",null,null,null,null,"P49674","Q9JMK2","A0A8I5Y728","A0A8I3PM90","A0A287A0K4","A0A5F8A7K9","GO:0005737; GO:0005829; GO:0030426; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:1990904","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0003723; GO:0016740","GO:0060070; GO:1990090; GO:0048512; GO:0032922; GO:0006281; GO:0006897; GO:0032091; GO:0030178; GO:0018105; GO:0016310; GO:1902004; GO:0090263; GO:2000052; GO:0032436; GO:0030177; GO:1905426; GO:0008104; GO:0006468; GO:0042752; GO:0032880; GO:0048511; GO:0007165","PTHR11909:SF428","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2453|UniProtKB=P49674","P06959; P00015; P00025; P00049; P00057"]
["Caseinkinase 1 epsilon",null,"CSNK1E","45","ms",null,1,1,6,2.1,8.1,8.1,"# 0736",".ALZ., .CCKR., .CD., .CSP., .DDR., .DEV., .DI., .DREP., .FOXO., .HHSP., .HIPPO., .OP., .OPA., .OT., .PARK., .ST., .TRASR., .WNT.","CCKR signaling map; Circadian clock system; Hedgehog signaling pathway; Parkinson disease; Wnt signaling pathway","CASEIN KINASE I ISOFORM EPSILON","canonical Wnt signaling pathway; cellular response to nerve growth factor stimulus; circadian behavior; circadian regulation of gene expression; DNA repair; endocytosis; negative regulation of protein binding; negative regulation of Wnt signaling pathway; peptidyl-serine phosphorylation; phosphorylation; positive regulation of amyloid-beta formation; positive regulation of canonical Wnt signaling pathway; positive regulation of non-canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of Wnt signaling pathway; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; protein localization; protein phosphorylation; regulation of circadian rhythm; regulation of protein localization; rhythmic process; signal transduction","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA binding; transferase activity","cytoplasm; cytosol; growth cone; neuron projection; neuronal cell body; nucleoplasm; nucleus; ribonucleoprotein complex","Wnt / hedgehog signaling","casein kinase 1 epsilon","http://www.ncbi.nlm.nih.gov/gene/?term=102800317","102800317","27373",null,null,null,null,"P49674","Q9JMK2","A0A8I5Y728","A0A8I3PM90","A0A287A0K4","A0A5F8A7K9","GO:0005737; GO:0005829; GO:0030426; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:1990904","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0003723; GO:0016740","GO:0060070; GO:1990090; GO:0048512; GO:0032922; GO:0006281; GO:0006897; GO:0032091; GO:0030178; GO:0018105; GO:0016310; GO:1902004; GO:0090263; GO:2000052; GO:0032436; GO:0030177; GO:1905426; GO:0008104; GO:0006468; GO:0042752; GO:0032880; GO:0048511; GO:0007165","PTHR11909:SF428","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2453|UniProtKB=P49674","P06959; P00015; P00025; P00049; P00057"]
["Caseinkinase 2 alpha",null,"CSNK2A1","42","rb",null,1,2,1.1000000000000001,8,2,2,"# 2163",".ALZ., .APH., .APO., .CADH., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .IMUF., .NFKB., .OP., .OPA., .PARK., .ST., .WNT.","Cadherin signaling pathway; Parkinson disease; Wnt signaling pathway","CASEIN KINASE II SUBUNIT ALPHA-RELATED","apoptotic process; cell cycle; chaperone-mediated protein folding; negative regulation of apoptotic signaling pathway; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of ubiquitin-dependent protein catabolic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of protein catabolic process; positive regulation of Wnt signaling pathway; protein phosphorylation; regulation of cell cycle; regulation of chromosome separation; rhythmic process; signal transduction; Wnt signaling pathway","ATP binding; Hsp90 protein binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytosol; nucleoplasm; nucleus; NuRD complex; PcG protein complex; plasma membrane; protein kinase CK2 complex; Sin3 complex","Wnt / hedgehog signaling","casein kinase 2 alpha 1","http://www.ncbi.nlm.nih.gov/gene/?term=1457","1457","12995","116549",null,null,null,"P68400","Q60737","P19139","A0A8I3NQ94","A0A287B9A8","A0A1D5RL05","GO:0005829; GO:0005654; GO:0005634; GO:0016581; GO:0031519; GO:0005886; GO:0005956; GO:0016580","GO:0005524; GO:0051879; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0047485; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:0007049; GO:0061077; GO:2001234; GO:0043154; GO:2000059; GO:0018105; GO:0018107; GO:0016310; GO:0030307; GO:0008284; GO:0045732; GO:0030177; GO:0006468; GO:0051726; GO:1905818; GO:0048511; GO:0007165; GO:0016055","PTHR24054:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2457|UniProtKB=P68400","P00012; P00049; P00057"]
["CASK",null,"CASK","120","ms",null,2,1,1,1,2,2,"# 0507",".CCP., .CP., .CSP., .DI., .IMUF., .INFM., .OP., .OPA., .OT., .PARK., .ST., .TRASR.","Parkinson disease; Inflammation mediated by chemokine and cytokine signaling pathway","PERIPHERAL PLASMA MEMBRANE PROTEIN CASK","calcium ion import; cell adhesion; establishment of localization in cell; GDP metabolic process; GMP metabolic process; negative regulation of cell-matrix adhesion; negative regulation of cellular response to growth factor stimulus; negative regulation of keratinocyte proliferation; negative regulation of wound healing; phosphorylation; positive regulation of calcium ion import; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of neurotransmitter secretion; regulation of synaptic vesicle exocytosis","ATP binding; calmodulin binding; guanylate kinase activity; kinase activity; neurexin family protein binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; signaling receptor binding; transferase activity","actin cytoskeleton; basement membrane; basolateral plasma membrane; cell junction; cell-cell junction; ciliary membrane; cytoplasm; cytosol; focal adhesion; membrane; nuclear lamina; nuclear matrix; nucleolus; nucleus; plasma membrane; presynaptic membrane; Schaffer collateral - CA1 synapse; synapse; vesicle","Neuronal signaling","calcium/calmodulin dependent serine protein kinase","http://www.ncbi.nlm.nih.gov/gene/?term=8573","8573","12361",null,null,null,"707428","O14936","O70589","A0A0G2JVI6","A0A8P0NG04","A0A286ZNV9","A0A1D5QVF6","GO:0015629; GO:0005604; GO:0016323; GO:0030054; GO:0005911; GO:0060170; GO:0005737; GO:0005829; GO:0005925; GO:0016020; GO:0005652; GO:0016363; GO:0005730; GO:0005634; GO:0005886; GO:0042734; GO:0098685; GO:0045202; GO:0031982","GO:0005524; GO:0005516; GO:0004385; GO:0016301; GO:0042043; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0005102; GO:0016740","GO:0070509; GO:0007155; GO:0051649; GO:0046710; GO:0046037; GO:0001953; GO:0090288; GO:0010839; GO:0061045; GO:0016310; GO:0090280; GO:0045944; GO:0006468; GO:0046928; GO:2000300","PTHR23122:SF40","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1497|UniProtKB=O14936","P00049; P00031"]
["Caspase 1",null,"CASP1","45","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1628",".APO., .CD., .CSP., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .NFKB., .OP., .OPA., .ST., .TNF., .VIR.",null,"CASPASE-1","activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; apoptotic signaling pathway; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to organic substance; cellular response to type II interferon; cytokine precursor processing; defense response to virus; icosanoid biosynthetic process; osmosensory signaling pathway; pattern recognition receptor signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of interleukin-1 beta production; positive regulation of tumor necrosis factor-mediated signaling pathway; protein autoprocessing; proteolysis; pyroptosis; regulation of apoptotic process; regulation of inflammatory response; signal transduction; signaling receptor ligand precursor processing","CARD domain binding; cysteine-type endopeptidase activator activity involved in apoptotic process; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; endopeptidase activity; hydrolase activity; identical protein binding; kinase binding; peptidase activity; protein binding","AIM2 inflammasome complex; cytoplasm; cytosol; inflammasome complex; IPAF inflammasome complex; membrane; microtubule; NLRP1 inflammasome complex; NLRP3 inflammasome complex; nucleolus; plasma membrane; protease inhibitor complex; protein-containing complex","Apoptosis","caspase 1","http://www.ncbi.nlm.nih.gov/gene/?term=834","834","12362",null,null,null,null,"P29466","P29452","A0A8I6ACX6",null,"A0A286ZZS2","A0A1D5QEN6","GO:0097169; GO:0005737; GO:0005829; GO:0061702; GO:0072557; GO:0016020; GO:0005874; GO:0072558; GO:0072559; GO:0005730; GO:0005886; GO:0097179; GO:0032991","GO:0050700; GO:0008656; GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0004175; GO:0016787; GO:0042802; GO:0019900; GO:0008233; GO:0005515","GO:0006919; GO:0006915; GO:0097190; GO:0071222; GO:0071260; GO:0071310; GO:0071346; GO:0140447; GO:0051607; GO:0046456; GO:0007231; GO:0002221; GO:0043280; GO:0043123; GO:0050729; GO:0032731; GO:1903265; GO:0016540; GO:0006508; GO:0070269; GO:0042981; GO:0050727; GO:0007165; GO:0140448","PTHR47901:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1499|UniProtKB=P29466"]
["Caspase 10",null,"CASP10","59","rb",null,2,7,4,4,4,4,"# 0452",".APO., .CD., .CSP., .DI., .FAS., .HEPB., .IMUF., .NFKB., .OP., .TNF.","FAS signaling pathway; Apoptosis signaling pathway","CASPASE-10","activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; apoptotic signaling pathway; execution phase of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB signaling; proteolysis; regulation of apoptotic process","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; death effector domain binding; hydrolase activity; peptidase activity; protein binding; ubiquitin protein ligase binding","CD95 death-inducing signaling complex; cytoplasm; cytosol; ripoptosome","Apoptosis","caspase 10","http://www.ncbi.nlm.nih.gov/gene/?term=843","843",null,null,null,null,null,"Q92851",null,null,null,"A0A286ZWN2","A0A1D5QQR1","GO:0031265; GO:0005737; GO:0005829; GO:0097342","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0035877; GO:0016787; GO:0008233; GO:0005515; GO:0031625","GO:0006919; GO:0006915; GO:0097190; GO:0097194; GO:0043123; GO:0006508; GO:0042981","PTHR10454:SF26","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1500|UniProtKB=Q92851","P00020; P00006"]
["Caspase 2",null,"CASP2","31","rb",null,7,2,7,7,7,7,"# 1615",".APO., .CD., .CSP., .DDR., .P53S.",null,"CASPASE-2","activation of cysteine-type endopeptidase activity involved in apoptotic process; aging; apoptotic process; apoptotic signaling pathway; brain development; cellular response to DNA damage stimulus; cellular response to mechanical stimulus; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; ectopic germ cell programmed cell death; execution phase of apoptosis; extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; luteolysis; negative regulation of apoptotic process; neural retina development; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of apoptotic process","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; enzyme binding; hydrolase activity; identical protein binding; peptidase activity; protein binding; protein domain specific binding","cytoplasm; cytosol; endopeptidase complex; membrane; mitochondrion; nucleolus; nucleus","Apoptosis","caspase 2","http://www.ncbi.nlm.nih.gov/gene/?term=835","835","12366","64314",null,null,null,"P42575","P29594","P55215","A0A8I3P3E6","A0A286ZY45","A0A5F7ZLY0","GO:0005737; GO:0005829; GO:1905369; GO:0016020; GO:0005739; GO:0005730; GO:0005634","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0019899; GO:0016787; GO:0042802; GO:0008233; GO:0005515; GO:0019904","GO:0006919; GO:0007568; GO:0006915; GO:0097190; GO:0007420; GO:0006974; GO:0071260; GO:0006977; GO:0035234; GO:0097194; GO:0097192; GO:0008630; GO:0001554; GO:0043066; GO:0003407; GO:0043065; GO:2001235; GO:0043525; GO:0016485; GO:0006508; GO:0042981","PTHR10454:SF151","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1503|UniProtKB=P42575"]
["Caspase 3",null,"CASP3","35, 19, 17","rb",null,1,1,1,1,1,1,"# 1996",".ALZ., .APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CRC., .CSP., .DDR., .DI., .DRR., .FAS., .HEPB., .HIF., .HUNT., .IMUF., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .RTK., .SCLC., .SREME., .ST., .TNF.","CCKR signaling map; Huntington disease; FAS signaling pathway; Apoptosis signaling pathway","CASPASE-3","anterior neural tube closure; apoptotic process; apoptotic signaling pathway; axonal fasciculation; B cell homeostasis; cell fate commitment; cellular response to DNA damage stimulus; cellular response to organic cyclic compound; cellular response to organic substance; cellular response to staurosporine; epithelial cell apoptotic process; erythrocyte differentiation; execution phase of apoptosis; fibroblast apoptotic process; glial cell apoptotic process; heart development; hippocampus development; intracellular signal transduction; intrinsic apoptotic signaling pathway in response to osmotic stress; keratinocyte differentiation; learning or memory; leukocyte apoptotic process; luteolysis; negative regulation of activated T cell proliferation; negative regulation of B cell proliferation; negative regulation of cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; neuron apoptotic process; neuron differentiation; neurotrophin TRK receptor signaling pathway; platelet formation; positive regulation of amyloid-beta formation; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein catabolic process; protein processing; proteolysis; regulation of macroautophagy; regulation of protein stability; response to amino acid; response to antibiotic; response to cobalt ion; response to estradiol; response to glucocorticoid; response to glucose; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to metal ion; response to nicotine; response to organic cyclic compound; response to organic substance; response to tumor necrosis factor; response to UV; response to wounding; response to xenobiotic stimulus; response to X-ray; sensory perception of sound; striated muscle cell differentiation; T cell homeostasis; wound healing","aspartic-type endopeptidase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; death receptor binding; endopeptidase activity; hydrolase activity; peptidase activity; phospholipase A2 activator activity; protease binding; protein binding; protein-containing complex binding","cytoplasm; cytosol; death-inducing signaling complex; membrane raft; neuronal cell body; nucleoplasm; nucleus","Apoptosis","caspase 3","http://www.ncbi.nlm.nih.gov/gene/?term=836","836","12367","25402",null,null,null,"P42574","P70677","P55213","A0A8I3NRN4",null,"F7FL02","GO:0005737; GO:0005829; GO:0031264; GO:0045121; GO:0043025; GO:0005654; GO:0005634","GO:0004190; GO:0004861; GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0005123; GO:0004175; GO:0016787; GO:0008233; GO:0016005; GO:0002020; GO:0005515; GO:0044877","GO:0061713; GO:0006915; GO:0097190; GO:0007413; GO:0001782; GO:0045165; GO:0006974; GO:0071407; GO:0071310; GO:0072734; GO:1904019; GO:0030218; GO:0097194; GO:0044346; GO:0034349; GO:0007507; GO:0021766; GO:0035556; GO:0008627; GO:0030216; GO:0007611; GO:0071887; GO:0001554; GO:0046007; GO:0030889; GO:0045786; GO:0045736; GO:0051402; GO:0030182; GO:0048011; GO:0030220; GO:1902004; GO:0043065; GO:0043525; GO:0030163; GO:0016485; GO:0006508; GO:0016241; GO:0031647; GO:0043200; GO:0046677; GO:0032025; GO:0032355; GO:0051384; GO:0009749; GO:0042542; GO:0001666; GO:0032496; GO:0010038; GO:0035094; GO:0014070; GO:0010033; GO:0034612; GO:0009411; GO:0009611; GO:0009410; GO:0010165; GO:0007605; GO:0051146; GO:0043029; GO:0042060","PTHR10454:SF198","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1504|UniProtKB=P42574","P06959; P00029; P00020; P00006"]
["Caspase 3 - cleaved","Asp175","CASP3","19, 17","rb",null,4,4,4,4,4,4,"# 2816",".ALZ., .APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CRC., .CSP., .DDR., .DI., .DRR., .FAS., .HEPB., .HIF., .HUNT., .IMUF., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .RTK., .SCLC., .SREME., .ST., .TNF.","CCKR signaling map; Huntington disease; FAS signaling pathway; Apoptosis signaling pathway","CASPASE-3","anterior neural tube closure; apoptotic process; apoptotic signaling pathway; axonal fasciculation; B cell homeostasis; cell fate commitment; cellular response to DNA damage stimulus; cellular response to organic cyclic compound; cellular response to organic substance; cellular response to staurosporine; epithelial cell apoptotic process; erythrocyte differentiation; execution phase of apoptosis; fibroblast apoptotic process; glial cell apoptotic process; heart development; hippocampus development; intracellular signal transduction; intrinsic apoptotic signaling pathway in response to osmotic stress; keratinocyte differentiation; learning or memory; leukocyte apoptotic process; luteolysis; negative regulation of activated T cell proliferation; negative regulation of B cell proliferation; negative regulation of cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; neuron apoptotic process; neuron differentiation; neurotrophin TRK receptor signaling pathway; platelet formation; positive regulation of amyloid-beta formation; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein catabolic process; protein processing; proteolysis; regulation of macroautophagy; regulation of protein stability; response to amino acid; response to antibiotic; response to cobalt ion; response to estradiol; response to glucocorticoid; response to glucose; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to metal ion; response to nicotine; response to organic cyclic compound; response to organic substance; response to tumor necrosis factor; response to UV; response to wounding; response to xenobiotic stimulus; response to X-ray; sensory perception of sound; striated muscle cell differentiation; T cell homeostasis; wound healing","aspartic-type endopeptidase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; death receptor binding; endopeptidase activity; hydrolase activity; peptidase activity; phospholipase A2 activator activity; protease binding; protein binding; protein-containing complex binding","cytoplasm; cytosol; death-inducing signaling complex; membrane raft; neuronal cell body; nucleoplasm; nucleus","Apoptosis","caspase 3","http://www.ncbi.nlm.nih.gov/gene/?term=836","836","12367","25402",null,null,null,"P42574","P70677","P55213","A0A8I3NRN4",null,"F7FL02","GO:0005737; GO:0005829; GO:0031264; GO:0045121; GO:0043025; GO:0005654; GO:0005634","GO:0004190; GO:0004861; GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0005123; GO:0004175; GO:0016787; GO:0008233; GO:0016005; GO:0002020; GO:0005515; GO:0044877","GO:0061713; GO:0006915; GO:0097190; GO:0007413; GO:0001782; GO:0045165; GO:0006974; GO:0071407; GO:0071310; GO:0072734; GO:1904019; GO:0030218; GO:0097194; GO:0044346; GO:0034349; GO:0007507; GO:0021766; GO:0035556; GO:0008627; GO:0030216; GO:0007611; GO:0071887; GO:0001554; GO:0046007; GO:0030889; GO:0045786; GO:0045736; GO:0051402; GO:0030182; GO:0048011; GO:0030220; GO:1902004; GO:0043065; GO:0043525; GO:0030163; GO:0016485; GO:0006508; GO:0016241; GO:0031647; GO:0043200; GO:0046677; GO:0032025; GO:0032355; GO:0051384; GO:0009749; GO:0042542; GO:0001666; GO:0032496; GO:0010038; GO:0035094; GO:0014070; GO:0010033; GO:0034612; GO:0009411; GO:0009611; GO:0009410; GO:0010165; GO:0007605; GO:0051146; GO:0043029; GO:0042060","PTHR10454:SF198","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1504|UniProtKB=P42574","P06959; P00029; P00020; P00006"]
["Caspase 5",null,"CASP5","47","rb",null,1,4,4,4,4,4,"# 0233",".APO., .CD., .CSP., .IMFR., .IMUR., .OP.",null,"CASPASE-5","activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; apoptotic signaling pathway; cellular response to mechanical stimulus; proteolysis; regulation of apoptotic process; regulation of inflammatory response; substantia nigra development","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; hydrolase activity; peptidase activity; protein binding","cytoplasm; cytosol; NLRP1 inflammasome complex","Apoptosis","caspase 5","http://www.ncbi.nlm.nih.gov/gene/?term=838","838","12363",null,null,null,null,"P51878","P70343","E9PSM0","A0A8I3MAQ7","A0A287BDB0","A0A1D5Q3B3","GO:0005737; GO:0005829; GO:0072558","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0016787; GO:0008233; GO:0005515","GO:0006919; GO:0006915; GO:0097190; GO:0071260; GO:0006508; GO:0042981; GO:0050727; GO:0021762","PTHR10454:SF243","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1506|UniProtKB=P51878"]
["Caspase 6",null,"CASP6","35, 15","rb",null,1,2,2,2,2,2,"# 0711",".APO., .CD., .CSP., .DI., .FAS., .HUNT., .OP., .P53S.","Huntington disease; FAS signaling pathway","CASPASE-6","activation of innate immune response; apoptotic process; cellular response to staurosporine; epithelial cell differentiation; execution phase of apoptosis; hepatocyte apoptotic process; intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of apoptotic process; positive regulation of necroptotic process; protein autoprocessing; proteolysis; pyroptosis","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; endopeptidase activity; hydrolase activity; identical protein binding; peptidase activity; protein binding","cytoplasm; cytosol; nucleoplasm; nucleus","Apoptosis","caspase 6","http://www.ncbi.nlm.nih.gov/gene/?term=839","839","12368","83584","487899",null,null,"P55212","O08738","F6Q5I5","A0A8I3Q9U5","A0A287B811","A0A1D5RJK7","GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0004197; GO:0097153; GO:0097200; GO:0008234; GO:0004175; GO:0016787; GO:0042802; GO:0008233; GO:0005515","GO:0002218; GO:0006915; GO:0072734; GO:0030855; GO:0097194; GO:0097284; GO:0072332; GO:0043065; GO:0060545; GO:0016540; GO:0006508; GO:0070269","PTHR10454:SF206","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1507|UniProtKB=P55212","P00029; P00020"]
["Caspase 6 - cleaved","Asp162","CASP6","18","rb",null,2,3,2,7,7,7,"# 0710",".APO., .CD., .CSP., .DI., .FAS., .HUNT., .OP., .P53S.","Huntington disease; FAS signaling pathway","CASPASE-6","activation of innate immune response; apoptotic process; cellular response to staurosporine; epithelial cell differentiation; execution phase of apoptosis; hepatocyte apoptotic process; intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of apoptotic process; positive regulation of necroptotic process; protein autoprocessing; proteolysis; pyroptosis","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; endopeptidase activity; hydrolase activity; identical protein binding; peptidase activity; protein binding","cytoplasm; cytosol; nucleoplasm; nucleus","Apoptosis","caspase 6","http://www.ncbi.nlm.nih.gov/gene/?term=839","839","12368","83584","487899",null,null,"P55212","O08738","F6Q5I5","A0A8I3Q9U5","A0A287B811","A0A1D5RJK7","GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0004197; GO:0097153; GO:0097200; GO:0008234; GO:0004175; GO:0016787; GO:0042802; GO:0008233; GO:0005515","GO:0002218; GO:0006915; GO:0072734; GO:0030855; GO:0097194; GO:0097284; GO:0072332; GO:0043065; GO:0060545; GO:0016540; GO:0006508; GO:0070269","PTHR10454:SF206","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1507|UniProtKB=P55212","P00029; P00020"]
["Caspase 7",null,"CASP7","35, 20","rb",null,2,2,1,2,6,6,"# 1163",".ALZ., .APO., .CANCER., .CANPTHW., .CD., .CSP., .DI., .FAS., .OP., .OPA., .ST., .TNF.","FAS signaling pathway; Apoptosis signaling pathway","CASPASE-7","apoptotic process; cellular response to staurosporine; defense response to bacterium; execution phase of apoptosis; fibroblast apoptotic process; heart development; intracellular signal transduction; lymphocyte apoptotic process; metabolic process; neuron apoptotic process; positive regulation of plasma membrane repair; protein processing; proteolysis; response to UV","aspartic-type endopeptidase activity; catalytic activity; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; hydrolase activity; peptidase activity; protein binding; RNA binding","cytoplasm; cytosol; extracellular region; extracellular space; nucleoplasm; nucleus","Apoptosis","caspase 7","http://www.ncbi.nlm.nih.gov/gene/?term=840","840","12369",null,null,null,null,"P55210","P97864","A0A0G2K9Z4","A0A8I3Q473",null,"A0A1D5QI24","GO:0005737; GO:0005829; GO:0005576; GO:0005615; GO:0005654; GO:0005634","GO:0004190; GO:0003824; GO:0004197; GO:0097153; GO:0097200; GO:0008234; GO:0016787; GO:0008233; GO:0005515; GO:0003723","GO:0006915; GO:0072734; GO:0042742; GO:0097194; GO:0044346; GO:0007507; GO:0035556; GO:0070227; GO:0008152; GO:0051402; GO:1905686; GO:0016485; GO:0006508; GO:0009411","PTHR10454:SF31","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1508|UniProtKB=P55210","P00020; P00006"]
["Caspase 7 - active",null,"CASP7","20","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2249",".ALZ., .APO., .CANCER., .CANPTHW., .CD., .CSP., .DI., .FAS., .OP., .OPA., .ST., .TNF.","FAS signaling pathway; Apoptosis signaling pathway","CASPASE-7","apoptotic process; cellular response to staurosporine; defense response to bacterium; execution phase of apoptosis; fibroblast apoptotic process; heart development; intracellular signal transduction; lymphocyte apoptotic process; metabolic process; neuron apoptotic process; positive regulation of plasma membrane repair; protein processing; proteolysis; response to UV","aspartic-type endopeptidase activity; catalytic activity; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; hydrolase activity; peptidase activity; protein binding; RNA binding","cytoplasm; cytosol; extracellular region; extracellular space; nucleoplasm; nucleus","Apoptosis","caspase 7","http://www.ncbi.nlm.nih.gov/gene/?term=840","840","12369",null,null,null,null,"P55210","P97864","A0A0G2K9Z4","A0A8I3Q473",null,"A0A1D5QI24","GO:0005737; GO:0005829; GO:0005576; GO:0005615; GO:0005654; GO:0005634","GO:0004190; GO:0003824; GO:0004197; GO:0097153; GO:0097200; GO:0008234; GO:0016787; GO:0008233; GO:0005515; GO:0003723","GO:0006915; GO:0072734; GO:0042742; GO:0097194; GO:0044346; GO:0007507; GO:0035556; GO:0070227; GO:0008152; GO:0051402; GO:1905686; GO:0016485; GO:0006508; GO:0009411","PTHR10454:SF31","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1508|UniProtKB=P55210","P00020; P00006"]
["Caspase 7 - cleaved","Asp198","CASP7","18","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2119",".ALZ., .APO., .CANCER., .CANPTHW., .CD., .CSP., .DI., .FAS., .OP., .OPA., .ST., .TNF.","FAS signaling pathway; Apoptosis signaling pathway","CASPASE-7","apoptotic process; cellular response to staurosporine; defense response to bacterium; execution phase of apoptosis; fibroblast apoptotic process; heart development; intracellular signal transduction; lymphocyte apoptotic process; metabolic process; neuron apoptotic process; positive regulation of plasma membrane repair; protein processing; proteolysis; response to UV","aspartic-type endopeptidase activity; catalytic activity; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; hydrolase activity; peptidase activity; protein binding; RNA binding","cytoplasm; cytosol; extracellular region; extracellular space; nucleoplasm; nucleus","Apoptosis","caspase 7","http://www.ncbi.nlm.nih.gov/gene/?term=840","840","12369",null,null,null,null,"P55210","P97864","A0A0G2K9Z4","A0A8I3Q473",null,"A0A1D5QI24","GO:0005737; GO:0005829; GO:0005576; GO:0005615; GO:0005654; GO:0005634","GO:0004190; GO:0003824; GO:0004197; GO:0097153; GO:0097200; GO:0008234; GO:0016787; GO:0008233; GO:0005515; GO:0003723","GO:0006915; GO:0072734; GO:0042742; GO:0097194; GO:0044346; GO:0007507; GO:0035556; GO:0070227; GO:0008152; GO:0051402; GO:1905686; GO:0016485; GO:0006508; GO:0009411","PTHR10454:SF31","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1508|UniProtKB=P55210","P00020; P00006"]
["Caspase 8",null,"CASP8","57, 43, 18","ms",null,2,4,7,7,4,4,"BG/MP # 074",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CD., .CSP., .DI., .DRR., .FAS., .HEPB., .HUNT., .IIR., .IMU., .IMUF., .IMUR., .INFM., .NFKB., .OP., .OT., .P53S., .TCR., .TNF., .TOLL., .TRASR.","Huntington disease; FAS signaling pathway; Apoptosis signaling pathway","CASPASE-8","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; apoptotic process; apoptotic signaling pathway; B cell activation; cellular response to mechanical stimulus; cellular response to organic cyclic compound; execution phase of apoptosis; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway via death domain receptors; heart development; macrophage differentiation; natural killer cell activation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of necroptotic process; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; positive regulation of macrophage differentiation; positive regulation of neuron death; positive regulation of proteolysis; protein processing; proteolysis; proteolysis involved in protein catabolic process; pyroptosis; regulation of apoptotic process; regulation of cytokine production; regulation of innate immune response; regulation of tumor necrosis factor-mediated signaling pathway; response to antibiotic; response to cobalt ion; response to cold; response to estradiol; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; self proteolysis; syncytiotrophoblast cell differentiation involved in labyrinthine layer development; T cell activation; TRAIL-activated apoptotic signaling pathway","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; death effector domain binding; death receptor binding; hydrolase activity; identical protein binding; peptidase activity; protein binding; protein-containing complex binding; scaffold protein binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding","CD95 death-inducing signaling complex; cell body; cytoplasm; cytoskeleton; cytosol; death-inducing signaling complex; membrane raft; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; protein-containing complex; ripoptosome","Apoptosis","caspase 8","http://www.ncbi.nlm.nih.gov/gene/?term=841","841","12370","64044",null,null,null,"Q14790","O89110","Q9JHX4","A0A8I3Q5B4","A0A287AK16","F7C587","GO:0031265; GO:0044297; GO:0005737; GO:0005856; GO:0005829; GO:0031264; GO:0045121; GO:0005741; GO:0005739; GO:0043005; GO:0005654; GO:0005634; GO:0032991; GO:0097342","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0035877; GO:0005123; GO:0016787; GO:0042802; GO:0008233; GO:0005515; GO:0044877; GO:0097110; GO:0005164; GO:0031625","GO:0097202; GO:0006919; GO:0001525; GO:0006915; GO:0097190; GO:0042113; GO:0071260; GO:0071407; GO:0097194; GO:0097191; GO:0008625; GO:0007507; GO:0030225; GO:0030101; GO:0043124; GO:0060546; GO:0043065; GO:0043123; GO:0032731; GO:0045651; GO:1901216; GO:0045862; GO:0016485; GO:0006508; GO:0051603; GO:0070269; GO:0042981; GO:0001817; GO:0045088; GO:0010803; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097264; GO:0060715; GO:0042110; GO:0036462","PTHR10454:SF162","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1509|UniProtKB=Q14790","P00029; P00020; P00006"]
["Caspase 8 - cleaved","Asp374/Asp391","CASP8","43, 41, 18","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0705",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CD., .CSP., .DI., .DRR., .FAS., .HEPB., .HUNT., .IIR., .IMU., .IMUF., .IMUR., .INFM., .NFKB., .OP., .OT., .P53S., .TCR., .TNF., .TOLL., .TRASR.","Huntington disease; FAS signaling pathway; Apoptosis signaling pathway","CASPASE-8","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; apoptotic process; apoptotic signaling pathway; B cell activation; cellular response to mechanical stimulus; cellular response to organic cyclic compound; execution phase of apoptosis; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway via death domain receptors; heart development; macrophage differentiation; natural killer cell activation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of necroptotic process; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; positive regulation of macrophage differentiation; positive regulation of neuron death; positive regulation of proteolysis; protein processing; proteolysis; proteolysis involved in protein catabolic process; pyroptosis; regulation of apoptotic process; regulation of cytokine production; regulation of innate immune response; regulation of tumor necrosis factor-mediated signaling pathway; response to antibiotic; response to cobalt ion; response to cold; response to estradiol; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; self proteolysis; syncytiotrophoblast cell differentiation involved in labyrinthine layer development; T cell activation; TRAIL-activated apoptotic signaling pathway","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; death effector domain binding; death receptor binding; hydrolase activity; identical protein binding; peptidase activity; protein binding; protein-containing complex binding; scaffold protein binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding","CD95 death-inducing signaling complex; cell body; cytoplasm; cytoskeleton; cytosol; death-inducing signaling complex; membrane raft; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; protein-containing complex; ripoptosome","Apoptosis","caspase 8","http://www.ncbi.nlm.nih.gov/gene/?term=841","841","12370","64044",null,null,null,"Q14790","O89110","Q9JHX4","A0A8I3Q5B4","A0A287AK16","F7C587","GO:0031265; GO:0044297; GO:0005737; GO:0005856; GO:0005829; GO:0031264; GO:0045121; GO:0005741; GO:0005739; GO:0043005; GO:0005654; GO:0005634; GO:0032991; GO:0097342","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0035877; GO:0005123; GO:0016787; GO:0042802; GO:0008233; GO:0005515; GO:0044877; GO:0097110; GO:0005164; GO:0031625","GO:0097202; GO:0006919; GO:0001525; GO:0006915; GO:0097190; GO:0042113; GO:0071260; GO:0071407; GO:0097194; GO:0097191; GO:0008625; GO:0007507; GO:0030225; GO:0030101; GO:0043124; GO:0060546; GO:0043065; GO:0043123; GO:0032731; GO:0045651; GO:1901216; GO:0045862; GO:0016485; GO:0006508; GO:0051603; GO:0070269; GO:0042981; GO:0001817; GO:0045088; GO:0010803; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097264; GO:0060715; GO:0042110; GO:0036462","PTHR10454:SF162","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1509|UniProtKB=Q14790","P00029; P00020; P00006"]
["Caspase 9",null,"CASP9","47, 37, 35, 25 (hu); 51, 39, 37 (rt, mk)","ms",null,1,1,1,8,1,1,"# 0707",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .EMC., .FAS., .HEPB., .HUNT., .NSCLC., .OP., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .VEGFS.","VEGF signaling pathway; Angiogenesis; FAS signaling pathway; PI3 kinase pathway; Apoptosis signaling pathway","CASPASE-9","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; apoptotic process; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to organic cyclic compound; cellular response to UV; epithelial cell apoptotic process; execution phase of apoptosis; fibroblast apoptotic process; glial cell apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; kidney development; leukocyte apoptotic process; neuron apoptotic process; platelet formation; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of apoptotic process; regulation of response to DNA damage stimulus; response to antibiotic; response to cobalt ion; response to estradiol; response to ischemia; response to lipopolysaccharide; response to organic cyclic compound; response to UV; signal transduction in response to DNA damage","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; enzyme activator activity; hydrolase activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding","apoptosome; caspase complex; cytoplasm; cytosol; mitochondrion; nucleus; protein-containing complex","Apoptosis","caspase 9","http://www.ncbi.nlm.nih.gov/gene/?term=842","842","12371",null,null,"100518913",null,"P55211","Q8C3Q9","A0A0G2K3V0","A0A8I3MAP5","F1SUV9","F7FNC1","GO:0043293; GO:0008303; GO:0005737; GO:0005829; GO:0005739; GO:0005634; GO:0032991","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0008047; GO:0016787; GO:0008233; GO:0005515; GO:0019901; GO:0017124","GO:0097202; GO:0006919; GO:0008635; GO:0007568; GO:0006915; GO:0071549; GO:0006974; GO:0071407; GO:0034644; GO:1904019; GO:0097194; GO:0044346; GO:0034349; GO:0097193; GO:0008630; GO:0001822; GO:0071887; GO:0051402; GO:0030220; GO:0043065; GO:0043525; GO:0016485; GO:0006508; GO:0042981; GO:2001020; GO:0046677; GO:0032025; GO:0032355; GO:0002931; GO:0032496; GO:0014070; GO:0009411; GO:0042770","PTHR10454:SF157","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1511|UniProtKB=P55211","P00056; P00005; P00020; P00048; P00006"]
["Caspase 9",null,"CASP9","47, 37, 35, 25, 17","rb",null,1,6,8,2,2,2,"# 2634",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .DDR., .DI., .EMC., .FAS., .HEPB., .HUNT., .NSCLC., .OP., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .VEGFS.","VEGF signaling pathway; Angiogenesis; FAS signaling pathway; PI3 kinase pathway; Apoptosis signaling pathway","CASPASE-9","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; apoptotic process; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to organic cyclic compound; cellular response to UV; epithelial cell apoptotic process; execution phase of apoptosis; fibroblast apoptotic process; glial cell apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; kidney development; leukocyte apoptotic process; neuron apoptotic process; platelet formation; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of apoptotic process; regulation of response to DNA damage stimulus; response to antibiotic; response to cobalt ion; response to estradiol; response to ischemia; response to lipopolysaccharide; response to organic cyclic compound; response to UV; signal transduction in response to DNA damage","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; enzyme activator activity; hydrolase activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding","apoptosome; caspase complex; cytoplasm; cytosol; mitochondrion; nucleus; protein-containing complex","Apoptosis","caspase 9","http://www.ncbi.nlm.nih.gov/gene/?term=842","842","12371",null,null,"100518913",null,"P55211","Q8C3Q9","A0A0G2K3V0","A0A8I3MAP5","F1SUV9","F7FNC1","GO:0043293; GO:0008303; GO:0005737; GO:0005829; GO:0005739; GO:0005634; GO:0032991","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0008047; GO:0016787; GO:0008233; GO:0005515; GO:0019901; GO:0017124","GO:0097202; GO:0006919; GO:0008635; GO:0007568; GO:0006915; GO:0071549; GO:0006974; GO:0071407; GO:0034644; GO:1904019; GO:0097194; GO:0044346; GO:0034349; GO:0097193; GO:0008630; GO:0001822; GO:0071887; GO:0051402; GO:0030220; GO:0043065; GO:0043525; GO:0016485; GO:0006508; GO:0042981; GO:2001020; GO:0046677; GO:0032025; GO:0032355; GO:0002931; GO:0032496; GO:0014070; GO:0009411; GO:0042770","PTHR10454:SF157","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1511|UniProtKB=P55211","P00056; P00005; P00020; P00048; P00006"]
["Caspase 9 - cleaved","Asp315","CASP9","35","rb",null,6,4,4,4,4,4,"# 0706",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .DDR., .DI., .EMC., .FAS., .HEPB., .HUNT., .NSCLC., .OP., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .VEGFS.","VEGF signaling pathway; Angiogenesis; FAS signaling pathway; PI3 kinase pathway; Apoptosis signaling pathway","CASPASE-9","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; apoptotic process; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to organic cyclic compound; cellular response to UV; epithelial cell apoptotic process; execution phase of apoptosis; fibroblast apoptotic process; glial cell apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; kidney development; leukocyte apoptotic process; neuron apoptotic process; platelet formation; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of apoptotic process; regulation of response to DNA damage stimulus; response to antibiotic; response to cobalt ion; response to estradiol; response to ischemia; response to lipopolysaccharide; response to organic cyclic compound; response to UV; signal transduction in response to DNA damage","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; enzyme activator activity; hydrolase activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding","apoptosome; caspase complex; cytoplasm; cytosol; mitochondrion; nucleus; protein-containing complex","Apoptosis","caspase 9","http://www.ncbi.nlm.nih.gov/gene/?term=842","842","12371",null,null,"100518913",null,"P55211","Q8C3Q9","A0A0G2K3V0","A0A8I3MAP5","F1SUV9","F7FNC1","GO:0043293; GO:0008303; GO:0005737; GO:0005829; GO:0005739; GO:0005634; GO:0032991","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0008047; GO:0016787; GO:0008233; GO:0005515; GO:0019901; GO:0017124","GO:0097202; GO:0006919; GO:0008635; GO:0007568; GO:0006915; GO:0071549; GO:0006974; GO:0071407; GO:0034644; GO:1904019; GO:0097194; GO:0044346; GO:0034349; GO:0097193; GO:0008630; GO:0001822; GO:0071887; GO:0051402; GO:0030220; GO:0043065; GO:0043525; GO:0016485; GO:0006508; GO:0042981; GO:2001020; GO:0046677; GO:0032025; GO:0032355; GO:0002931; GO:0032496; GO:0014070; GO:0009411; GO:0042770","PTHR10454:SF157","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1511|UniProtKB=P55211","P00056; P00005; P00020; P00048; P00006"]
["Caspase 9 - cleaved","Asp330","CASP9","37","rb",null,7,4,4,4,4,4,"# 1265",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .DDR., .DI., .EMC., .FAS., .HEPB., .HUNT., .NSCLC., .OP., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .VEGFS.","VEGF signaling pathway; Angiogenesis; FAS signaling pathway; PI3 kinase pathway; Apoptosis signaling pathway","CASPASE-9","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; apoptotic process; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to organic cyclic compound; cellular response to UV; epithelial cell apoptotic process; execution phase of apoptosis; fibroblast apoptotic process; glial cell apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; kidney development; leukocyte apoptotic process; neuron apoptotic process; platelet formation; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of apoptotic process; regulation of response to DNA damage stimulus; response to antibiotic; response to cobalt ion; response to estradiol; response to ischemia; response to lipopolysaccharide; response to organic cyclic compound; response to UV; signal transduction in response to DNA damage","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; enzyme activator activity; hydrolase activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding","apoptosome; caspase complex; cytoplasm; cytosol; mitochondrion; nucleus; protein-containing complex","Apoptosis","caspase 9","http://www.ncbi.nlm.nih.gov/gene/?term=842","842","12371",null,null,"100518913",null,"P55211","Q8C3Q9","A0A0G2K3V0","A0A8I3MAP5","F1SUV9","F7FNC1","GO:0043293; GO:0008303; GO:0005737; GO:0005829; GO:0005739; GO:0005634; GO:0032991","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0008047; GO:0016787; GO:0008233; GO:0005515; GO:0019901; GO:0017124","GO:0097202; GO:0006919; GO:0008635; GO:0007568; GO:0006915; GO:0071549; GO:0006974; GO:0071407; GO:0034644; GO:1904019; GO:0097194; GO:0044346; GO:0034349; GO:0097193; GO:0008630; GO:0001822; GO:0071887; GO:0051402; GO:0030220; GO:0043065; GO:0043525; GO:0016485; GO:0006508; GO:0042981; GO:2001020; GO:0046677; GO:0032025; GO:0032355; GO:0002931; GO:0032496; GO:0014070; GO:0009411; GO:0042770","PTHR10454:SF157","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1511|UniProtKB=P55211","P00056; P00005; P00020; P00048; P00006"]
["Caspase 9 - phospho","Ser196","CASP9","46","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2397",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .EMC., .FAS., .HEPB., .HUNT., .NSCLC., .OP., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .VEGFS.","VEGF signaling pathway; Angiogenesis; FAS signaling pathway; PI3 kinase pathway; Apoptosis signaling pathway","CASPASE-9","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; apoptotic process; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to organic cyclic compound; cellular response to UV; epithelial cell apoptotic process; execution phase of apoptosis; fibroblast apoptotic process; glial cell apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; kidney development; leukocyte apoptotic process; neuron apoptotic process; platelet formation; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of apoptotic process; regulation of response to DNA damage stimulus; response to antibiotic; response to cobalt ion; response to estradiol; response to ischemia; response to lipopolysaccharide; response to organic cyclic compound; response to UV; signal transduction in response to DNA damage","cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; enzyme activator activity; hydrolase activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding","apoptosome; caspase complex; cytoplasm; cytosol; mitochondrion; nucleus; protein-containing complex",null,"caspase 9","http://www.ncbi.nlm.nih.gov/gene/?term=842","842","12371",null,null,"100518913",null,"P55211","Q8C3Q9","A0A0G2K3V0","A0A8I3MAP5","F1SUV9","F7FNC1","GO:0043293; GO:0008303; GO:0005737; GO:0005829; GO:0005739; GO:0005634; GO:0032991","GO:0004197; GO:0097153; GO:0097199; GO:0097200; GO:0008234; GO:0008047; GO:0016787; GO:0008233; GO:0005515; GO:0019901; GO:0017124","GO:0097202; GO:0006919; GO:0008635; GO:0007568; GO:0006915; GO:0071549; GO:0006974; GO:0071407; GO:0034644; GO:1904019; GO:0097194; GO:0044346; GO:0034349; GO:0097193; GO:0008630; GO:0001822; GO:0071887; GO:0051402; GO:0030220; GO:0043065; GO:0043525; GO:0016485; GO:0006508; GO:0042981; GO:2001020; GO:0046677; GO:0032025; GO:0032355; GO:0002931; GO:0032496; GO:0014070; GO:0009411; GO:0042770","PTHR10454:SF157","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1511|UniProtKB=P55211","P00056; P00005; P00020; P00048; P00006"]
["Caveolin-1",null,"CAV1","24, 21","rb",null,1,2,2,2,1,6,"# 1188",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .DRR., .GPCR., .GPROT., .HIF., .IMUF., .INFM., .INT., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .PLAT., .RTK., .SREME., .ST., .STAT., .TCR., .TGFB., .TRASR., .UBI., .WNT.","Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway","CAVEOLIN-1","angiogenesis; angiotensin-activated signaling pathway involved in heart process; apoptotic signaling pathway; basement membrane organization; calcium ion homeostasis; calcium ion transport; caveola assembly; caveolin-mediated endocytosis; cell differentiation; cell population proliferation; cellular calcium ion homeostasis; cellular nitric oxide homeostasis; cellular response to exogenous dsRNA; cellular response to hyperoxia; cellular response to peptide hormone stimulus; cellular response to transforming growth factor beta stimulus; cholesterol homeostasis; cholesterol transport; cytokine-mediated signaling pathway; endothelial cell proliferation; establishment of localization in cell; fibroblast proliferation; glandular epithelial cell differentiation; insulin receptor internalization; lactation; lipid storage; maintenance of protein location in cell; mammary gland development; mammary gland involution; MAPK cascade; membrane depolarization; muscle cell cellular homeostasis; negative regulation of anoikis; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; negative regulation of cytokine-mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of fibroblast proliferation; negative regulation of inward rectifier potassium channel activity; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of necroptotic process; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-tyrosine autophosphorylation; negative regulation of pinocytosis; negative regulation of potassium ion transmembrane transport; negative regulation of protein binding; negative regulation of protein tyrosine kinase activity; negative regulation of protein ubiquitination; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of signal transduction; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; nitric oxide biosynthetic process; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt signaling pathway; positive regulation of catalytic activity; positive regulation of cell adhesion molecule production; positive regulation of cell migration; positive regulation of cholesterol efflux; positive regulation of cold-induced thermogenesis; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of gap junction assembly; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of vasoconstriction; post-transcriptional regulation of gene expression; protein localization; protein localization to basolateral plasma membrane; protein localization to plasma membrane raft; protein transport; receptor internalization; receptor internalization involved in canonical Wnt signaling pathway; receptor-mediated endocytosis of virus by host cell; regulation of blood coagulation; regulation of cardiac muscle cell action potential involved in regulation of contraction; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of cytosolic calcium ion concentration; regulation of entry of bacterium into host cell; regulation of fatty acid metabolic process; regulation of heart rate by cardiac conduction; regulation of membrane repolarization during action potential; regulation of peptidase activity; regulation of ruffle assembly; regulation of smooth muscle contraction; regulation of the force of heart contraction; regulation of the force of heart contraction by chemical signal; regulation of ventricular cardiac muscle cell action potential; response to bacterium; response to calcium ion; response to estrogen; response to hypoxia; response to ischemia; response to progesterone; skeletal muscle tissue development; T cell costimulation; triglyceride metabolic process; tyrosine phosphorylation of STAT protein; vasculogenesis; vasoconstriction; vesicle organization","ATPase binding; cholesterol binding; enzyme binding; identical protein binding; inward rectifier potassium channel inhibitor activity; molecular adaptor activity; nitric-oxide synthase binding; patched binding; peptidase activator activity; protein binding; protein heterodimerization activity; protein kinase binding; protein-containing complex binding; protein-macromolecule adaptor activity; signaling receptor binding; small GTPase binding; transmembrane transporter binding","acrosomal membrane; caveola; caveolar macromolecular signaling complex; cell cortex; cilium; cytoplasmic vesicle; early endosome membrane; endocytic vesicle membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; focal adhesion; Golgi apparatus; Golgi membrane; lipid droplet; membrane; membrane raft; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; sarcolemma","Vesicular trafficking / cell adhesion / apoptosis","caveolin 1","http://www.ncbi.nlm.nih.gov/gene/?term=857","857","12389",null,null,null,null,"Q03135","P49817","A0A0G2K682",null,"A0A286ZJQ9","A0A5K1V3S2","GO:0002080; GO:0005901; GO:0002095; GO:0005938; GO:0005929; GO:0031410; GO:0031901; GO:0030666; GO:0005783; GO:0005789; GO:0005768; GO:0005925; GO:0005794; GO:0000139; GO:0005811; GO:0016020; GO:0045121; GO:0048471; GO:0005886; GO:0032991; GO:0042383","GO:0051117; GO:0015485; GO:0019899; GO:0042802; GO:0070320; GO:0060090; GO:0050998; GO:0005113; GO:0016504; GO:0005515; GO:0046982; GO:0019901; GO:0044877; GO:0030674; GO:0005102; GO:0031267; GO:0044325","GO:0001525; GO:0086098; GO:0097190; GO:0071711; GO:0055074; GO:0006816; GO:0070836; GO:0072584; GO:0030154; GO:0008283; GO:0006874; GO:0033484; GO:0071360; GO:0071455; GO:0071375; GO:0071560; GO:0042632; GO:0030301; GO:0019221; GO:0001935; GO:0051649; GO:0048144; GO:0002067; GO:0038016; GO:0007595; GO:0019915; GO:0032507; GO:0030879; GO:0060056; GO:0000165; GO:0051899; GO:0046716; GO:2000811; GO:0090090; GO:0008285; GO:0001960; GO:0001937; GO:0030857; GO:0048147; GO:1903609; GO:0043407; GO:0043409; GO:0060546; GO:0045019; GO:0051001; GO:0033137; GO:1900085; GO:0048550; GO:1901380; GO:0032091; GO:0061099; GO:0031397; GO:0046426; GO:0009968; GO:0000122; GO:0030512; GO:0042532; GO:0006809; GO:0010524; GO:0090263; GO:0043085; GO:0060355; GO:0030335; GO:0010875; GO:0120162; GO:1903071; GO:2001238; GO:1903598; GO:0010628; GO:2001244; GO:0051092; GO:0033138; GO:0032092; GO:0031398; GO:0034141; GO:0045907; GO:0010608; GO:0008104; GO:1903361; GO:0044860; GO:0015031; GO:0031623; GO:2000286; GO:0019065; GO:0030193; GO:0098909; GO:1901844; GO:0051480; GO:2000535; GO:0019217; GO:0086091; GO:0098903; GO:0052547; GO:1900027; GO:0006940; GO:0002026; GO:0003057; GO:0098911; GO:0009617; GO:0051592; GO:0043627; GO:0001666; GO:0002931; GO:0032570; GO:0007519; GO:0031295; GO:0006641; GO:0007260; GO:0001570; GO:0042310; GO:0016050","PTHR10844:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1527|UniProtKB=Q03135","P06664; P00034"]
["CBP",null,"CREBBP","300","rb",null,2,7,4,4,7,4,"# 1095",".cAMP., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CSP., .DEV., .DI., .FOXO., .GPCR., .GPROT., .HEPB., .HHSP., .HIF., .HUNT., .NOTCH., .OP., .OPA., .OT., .P53S., .PRC., .RCC., .RTK., .SREME., .ST., .STAT., .TGFB., .TRASR., .WNT.","Transcription regulation by bZIP transcription factor; p53 pathway; TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway; Huntington disease; Hedgehog signaling pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Hypoxia response via HIF activation; Wnt signaling pathway","CREB-BINDING PROTEIN","cellular response to UV; DNA-templated transcription; embryonic digit morphogenesis; histone acetylation; homeostatic process; negative regulation of transcription by RNA polymerase I; negative regulation of transcription by RNA polymerase II; N-terminal peptidyl-lysine acetylation; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; protein acetylation; protein destabilization; protein-containing complex assembly; regulation of cellular response to heat; regulation of DNA-templated transcription; regulation of smoothened signaling pathway; response to hypoxia; response to stimulus; rhythmic process; signal transduction; stimulatory C-type lectin receptor signaling pathway","acetyltransferase activity; acyltransferase activity; chromatin binding; chromatin DNA binding; damaged DNA binding; DNA-binding transcription factor binding; histone acetyltransferase activity; metal ion binding; MRF binding; p53 binding; peptide N-acetyltransferase activity; peptide-lysine-N-acetyltransferase activity; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity; transcription coactivator binding; transcription coregulator activity; transcription corepressor activity; transferase activity; zinc ion binding","chromatin; cytoplasm; cytosol; histone acetyltransferase complex; intracellular organelle; nuclear body; nucleoplasm; nucleus; transcription regulator complex","?","CREB binding protein","http://www.ncbi.nlm.nih.gov/gene/?term=1387","1387",null,null,null,null,null,"Q92793","A0A0U1RP23","A0A8I5ZRH6","A0A8P0NKL5","A0A287AQQ6","A0A5F7ZCI9","GO:0000785; GO:0005737; GO:0005829; GO:0000123; GO:0043229; GO:0016604; GO:0005654; GO:0005634; GO:0005667","GO:0016407; GO:0016746; GO:0003682; GO:0031490; GO:0003684; GO:0140297; GO:0004402; GO:0046872; GO:0043426; GO:0002039; GO:0034212; GO:0061733; GO:0005515; GO:0061629; GO:0003713; GO:0001223; GO:0003712; GO:0003714; GO:0016740; GO:0008270","GO:0034644; GO:0006351; GO:0042733; GO:0016573; GO:0042592; GO:0016479; GO:0000122; GO:0018076; GO:0045893; GO:0045944; GO:0030511; GO:0006473; GO:0031648; GO:0065003; GO:1900034; GO:0006355; GO:0008589; GO:0001666; GO:0050896; GO:0048511; GO:0007165; GO:0002223","PTHR13808:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2348|UniProtKB=Q92793","P00055; P00059; P00052; P06664; P00029; P00025; P00026; P00030; P00057"]
["CCDC43",null,"CCDC43","25","rb",null,2,1,7,7,7,7,"# 0914",null,null,"COILED-COIL DOMAIN-CONTAINING PROTEIN 43",null,"protein binding","cytosol",null,"coiled-coil domain containing 43","http://www.ncbi.nlm.nih.gov/gene/?term=124808","124808","52715",null,null,null,null,"Q96MW1","Q9CR29","A0A8I6AEV6","A0A8I3N397","F1RQZ4","F6TL42","GO:0005829","GO:0005515",null,"PTHR31684:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=26472|UniProtKB=Q96MW1"]
["CD11b",null,"ITGAM","170","rb",null,2,6,"n/a","n/a","n/a","n/a","# 2234",".AML., .APO., .CANCER., .CD., .CSP., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INT., .OP., .OPA., .ST.","Integrin signalling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","INTEGRIN ALPHA-M","amyloid-beta clearance; apoptotic signaling pathway; cell adhesion; cell adhesion mediated by integrin; cell surface receptor signaling pathway involved in cell-cell signaling; cell-cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; cell-matrix adhesion; complement-mediated synapse pruning; ectodermal cell differentiation; forebrain development; immune system process; innate immune response; integrin-mediated signaling pathway; microglial cell activation; negative regulation of dopamine metabolic process; phagocytosis, engulfment; positive regulation of hippocampal neuron apoptotic process; positive regulation of microglial cell mediated cytotoxicity; positive regulation of neuron death; positive regulation of neutrophil degranulation; positive regulation of prostaglandin-E synthase activity; positive regulation of protein targeting to membrane; positive regulation of superoxide anion generation; receptor-mediated endocytosis; vertebrate eye-specific patterning","amyloid-beta binding; cargo receptor activity; complement component C3b binding; heat shock protein binding; integrin binding; metal ion binding; protein binding; protein-containing complex binding","cell surface; external side of plasma membrane; extracellular exosome; extracellular space; integrin alphaM-beta2 complex; integrin complex; membrane; membrane raft; plasma membrane; plasma membrane raft; specific granule membrane; tertiary granule membrane",null,"integrin subunit alpha M","http://www.ncbi.nlm.nih.gov/gene/?term=3684","3684",null,null,"489928",null,null,"P11215","F6YXU0","A0A0G2K4L8","A0A8I3NV00",null,"A0A1D5QVS1","GO:0009986; GO:0009897; GO:0070062; GO:0005615; GO:0034688; GO:0008305; GO:0016020; GO:0045121; GO:0005886; GO:0044853; GO:0035579; GO:0070821","GO:0001540; GO:0038024; GO:0001851; GO:0031072; GO:0005178; GO:0046872; GO:0005515; GO:0044877","GO:0097242; GO:0097190; GO:0007155; GO:0033627; GO:1905114; GO:0098609; GO:0098742; GO:0007160; GO:0150062; GO:0010668; GO:0030900; GO:0002376; GO:0045087; GO:0007229; GO:0001774; GO:0045963; GO:0006911; GO:0110090; GO:1904151; GO:1901216; GO:0043315; GO:2000363; GO:0090314; GO:0032930; GO:0006898; GO:0150064","PTHR23220:SF130","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6149|UniProtKB=P11215","P00034; P00031"]
["CD133 (PROM1)",null,"PROM1","97","rb",null,2,4,7,4,4,4,"# 0460",null,null,"PROMININ-1","camera-type eye photoreceptor cell differentiation; glomerular parietal epithelial cell differentiation; photoreceptor cell maintenance; podocyte differentiation; positive regulation of nephron tubule epithelial cell differentiation; retina layer formation; retina morphogenesis in camera-type eye","actinin binding; cadherin binding; cholesterol binding; protein binding","apical plasma membrane; cell projection; cell surface; cellular anatomical entity; cilium; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; extracellular space; membrane; microvillus; microvillus membrane; photoreceptor outer segment; photoreceptor outer segment membrane; plasma membrane; prominosome; vesicle","MAPK signaling / Akt signaling","prominin 1","http://www.ncbi.nlm.nih.gov/gene/?term=8842","8842","19126",null,null,null,"714610","O43490","A0A0G2JDH9","A0A0G2JT89","A0A8P0NGW0","A0A287B1A8","A0A5F8A3C4","GO:0016324; GO:0042995; GO:0009986; GO:0110165; GO:0005929; GO:0005783; GO:0005793; GO:0070062; GO:0005615; GO:0016020; GO:0005902; GO:0031528; GO:0001750; GO:0042622; GO:0005886; GO:0071914; GO:0031982","GO:0042805; GO:0045296; GO:0015485; GO:0005515","GO:0060219; GO:0072139; GO:0045494; GO:0072112; GO:2000768; GO:0010842; GO:0060042","PTHR22730:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9454|UniProtKB=O43490"]
["CD14",null,"CD14","60-50","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2817",".AML., .APO., .CANCER., .CD., .CSP., .DRR., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OPA., .OT., .RTK., .ST., .TOLL., .TRASR.","Toll receptor signaling pathway","MONOCYTE DIFFERENTIATION ANTIGEN CD14","apoptotic process; cell surface pattern recognition receptor signaling pathway; cell surface receptor signaling pathway; cellular response to diacyl bacterial lipopeptide; cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; cellular response to molecule of bacterial origin; cellular response to triacyl bacterial lipopeptide; immune system process; inflammatory response; innate immune response; lipopolysaccharide-mediated signaling pathway; phagocytosis; positive regulation of cytokine production; positive regulation of endocytosis; positive regulation of interleukin-8 production; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor production; positive regulation of type I interferon production; positive regulation of type II interferon production; receptor-mediated endocytosis; response to bacterium; response to electrical stimulus; response to ethanol; response to heat; response to lipopolysaccharide; response to magnesium ion; response to molecule of bacterial origin; response to tumor necrosis factor; toll-like receptor 4 signaling pathway","lipopolysaccharide binding; lipopolysaccharide immune receptor activity; lipoteichoic acid binding; opsonin receptor activity; peptidoglycan immune receptor activity; protein binding","cell surface; endosome membrane; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; Golgi apparatus; lipopolysaccharide receptor complex; membrane; membrane raft; plasma membrane; secretory granule membrane",null,"CD14 molecule","http://www.ncbi.nlm.nih.gov/gene/?term=929","929","12475","60350",null,null,"697482","P08571","P10810","Q63691",null,"A2SW51","B3Y6B8","GO:0009986; GO:0010008; GO:0009897; GO:0070062; GO:0005576; GO:0005615; GO:0005794; GO:0046696; GO:0016020; GO:0045121; GO:0005886; GO:0030667","GO:0001530; GO:0001875; GO:0070891; GO:0001847; GO:0016019; GO:0005515","GO:0006915; GO:0002752; GO:0007166; GO:0071726; GO:0071222; GO:0071223; GO:0071219; GO:0071727; GO:0002376; GO:0006954; GO:0045087; GO:0031663; GO:0006909; GO:0001819; GO:0045807; GO:0032757; GO:0031666; GO:1901224; GO:0034145; GO:0032760; GO:0032481; GO:0032729; GO:0006898; GO:0009617; GO:0051602; GO:0045471; GO:0009408; GO:0032496; GO:0032026; GO:0002237; GO:0034612; GO:0034142","PTHR10630:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1628|UniProtKB=P08571","P00054"]
["CD3 epsilon",null,"CD3E","21","rt",null,2.1,4,4,4,4,4,"# 0567",".APO., .CD., .CSP., .DEV., .GPCR., .GPROT., .HHSP., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .ST., .TCD., .TCR., .TMAT., .TRASR.","T cell activation","T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN","adaptive immune response; alpha-beta T cell activation; apoptotic signaling pathway; calcium-mediated signaling; CD4-positive, alpha-beta T cell proliferation; cell surface receptor signaling pathway; cerebellum development; dendrite development; G protein-coupled receptor signaling pathway; gamma-delta T cell activation; immune system process; lymphocyte activation; negative regulation of gene expression; negative regulation of smoothened signaling pathway; negative thymic T cell selection; peptidyl-tyrosine phosphorylation; positive regulation of calcium-mediated signaling; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of cell-matrix adhesion; positive regulation of gene expression; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell activation; positive regulation of T cell anergy; positive regulation of T cell proliferation; positive regulation of type II interferon production; positive thymic T cell selection; protein-containing complex assembly; regulation of apoptotic process; signal complex assembly; smoothened signaling pathway; T cell activation; T cell anergy; T cell costimulation; T cell proliferation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","identical protein binding; protein binding; protein kinase binding; SH3 domain binding; signaling receptor complex adaptor activity; T cell receptor binding; transmembrane signaling receptor activity","alpha-beta T cell receptor complex; cell body; cell-cell junction; dendritic spine; endoplasmic reticulum; external side of plasma membrane; gamma-delta T cell receptor complex; Golgi apparatus; immunological synapse; membrane; plasma membrane; T cell receptor complex","Cluster of differentiation antigen / cell marker","CD3 epsilon subunit of T-cell receptor complex","http://www.ncbi.nlm.nih.gov/gene/?term=916","916","12501",null,"442981",null,null,"P07766","P22646","A0A0G2K986","P27597",null,"A0A5F7ZDC9","GO:0042105; GO:0044297; GO:0005911; GO:0043197; GO:0005783; GO:0009897; GO:0042106; GO:0005794; GO:0001772; GO:0016020; GO:0005886; GO:0042101","GO:0042802; GO:0005515; GO:0019901; GO:0017124; GO:0030159; GO:0042608; GO:0004888","GO:0002250; GO:0046631; GO:0097190; GO:0019722; GO:0035739; GO:0007166; GO:0021549; GO:0016358; GO:0007186; GO:0046629; GO:0002376; GO:0046649; GO:0010629; GO:0045879; GO:0045060; GO:0018108; GO:0050850; GO:2000563; GO:0033634; GO:0001954; GO:0010628; GO:0032743; GO:0032753; GO:0050731; GO:0050870; GO:0002669; GO:0042102; GO:0032729; GO:0045059; GO:0065003; GO:0042981; GO:0007172; GO:0007224; GO:0042110; GO:0002870; GO:0031295; GO:0042098; GO:0050852; GO:0007169","PTHR10570:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1674|UniProtKB=P07766","P00053"]
["CD36",null,"CD36","53","rb",null,1,1,5,8,8,1.1000000000000001,"# 1400",".AMPK., .CSP., .IMFR., .IMUF., .IMUR., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .OXS., .PLAT., .RTK., .SREME., .ST., .TOLL., .TRASR.",null,"PLATELET GLYCOPROTEIN 4","amyloid fibril formation; amyloid-beta clearance by cellular catabolic process; apoptotic cell clearance; blood coagulation; cell adhesion; cell surface receptor signaling pathway; cellular response to amyloid-beta; cellular response to bacterial lipopeptide; cellular response to diacyl bacterial lipopeptide; cellular response to hydroperoxide; cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; cellular response to low-density lipoprotein particle stimulus; cellular response to oxidised low-density lipoprotein particle stimulus; cGMP-mediated signaling; cholesterol import; cholesterol transport; defense response to Gram-positive bacterium; energy homeostasis; fatty acid metabolic process; intestinal absorption; intestinal cholesterol absorption; lipid metabolic process; lipid storage; lipid transport; lipid transport across blood-brain barrier; lipoprotein transport; long-chain fatty acid import across plasma membrane; long-chain fatty acid import into cell; long-chain fatty acid transport; low-density lipoprotein particle clearance; low-density lipoprotein particle mediated signaling; MAPK cascade; negative regulation of gene expression; negative regulation of protein import into nucleus; negative regulation of transcription by RNA polymerase II; nitric oxide mediated signal transduction; oxidised low-density lipoprotein particle clearance; phagocytosis, engulfment; phagocytosis, recognition; plasma lipoprotein particle clearance; positive regulation of blood coagulation; positive regulation of blood microparticle formation; positive regulation of cell death; positive regulation of cell-matrix adhesion; positive regulation of cholesterol storage; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of macrophage cytokine production; positive regulation of macrophage derived foam cell differentiation; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phagocytosis, engulfment; positive regulation of reactive oxygen species biosynthetic process; positive regulation of reactive oxygen species metabolic process; positive regulation of tumor necrosis factor production; production of molecular mediator involved in inflammatory response; receptor internalization; receptor-mediated endocytosis; regulation of action potential; regulation of lipopolysaccharide-mediated signaling pathway; regulation of protein-containing complex assembly; regulation of removal of superoxide radicals; regulation of toll-like receptor signaling pathway; response to bacterium; response to fatty acid; response to linoleic acid; response to lipid; response to stilbenoid; sensory perception of taste; short-chain fatty acid transport; triglyceride transport","amyloid-beta binding; high-density lipoprotein particle binding; lipid binding; lipoprotein particle binding; lipoteichoic acid immune receptor activity; long-chain fatty acid transporter activity; low-density lipoprotein particle binding; low-density lipoprotein particle receptor activity; oleate transmembrane transporter activity; oxidised low-density lipoprotein particle receptor activity; protein binding; protein-containing complex binding; scavenger receptor activity; short-chain fatty acid transmembrane transporter activity; thrombospondin receptor activity; Toll-like receptor binding; transforming growth factor beta binding","apical part of cell; apical plasma membrane; brush border membrane; caveola; cell periphery; cell surface; cytoplasm; endocytic vesicle membrane; external side of plasma membrane; extracellular space; Golgi apparatus; membrane; membrane raft; phagocytic vesicle; plasma membrane; platelet alpha granule membrane; receptor complex; specific granule membrane","Adhesion","CD36 molecule","http://www.ncbi.nlm.nih.gov/gene/?term=948","948","12491",null,null,null,null,"P16671","Q08857","A0A096MJ39","A0A8I3PQY3","A0A5G2RCP1","A0A1D5QRS8","GO:0045177; GO:0016324; GO:0031526; GO:0005901; GO:0071944; GO:0009986; GO:0005737; GO:0030666; GO:0009897; GO:0005615; GO:0005794; GO:0016020; GO:0045121; GO:0045335; GO:0005886; GO:0031092; GO:0043235; GO:0035579","GO:0001540; GO:0008035; GO:0008289; GO:0071813; GO:0070892; GO:0005324; GO:0030169; GO:0005041; GO:1901480; GO:0150025; GO:0005515; GO:0044877; GO:0005044; GO:0015636; GO:0070053; GO:0035325; GO:0050431","GO:1990000; GO:0150094; GO:0043277; GO:0007596; GO:0007155; GO:0007166; GO:1904646; GO:0071221; GO:0071726; GO:0071447; GO:0071222; GO:0071223; GO:0071404; GO:0140052; GO:0019934; GO:0070508; GO:0030301; GO:0050830; GO:0097009; GO:0006631; GO:0050892; GO:0030299; GO:0006629; GO:0019915; GO:0006869; GO:1990379; GO:0042953; GO:0015911; GO:0044539; GO:0015909; GO:0034383; GO:0055096; GO:0000165; GO:0010629; GO:0042308; GO:0000122; GO:0007263; GO:0150024; GO:0006911; GO:0006910; GO:0034381; GO:0030194; GO:2000334; GO:0010942; GO:0001954; GO:0010886; GO:0120162; GO:0007204; GO:0070374; GO:0010628; GO:0043123; GO:0032731; GO:0032735; GO:0032755; GO:0060907; GO:0010744; GO:0043410; GO:0051092; GO:0045429; GO:1900227; GO:0050731; GO:0060100; GO:1903428; GO:2000379; GO:0032760; GO:0002532; GO:0031623; GO:0006898; GO:0098900; GO:0031664; GO:0043254; GO:2000121; GO:0034121; GO:0009617; GO:0070542; GO:0070543; GO:0033993; GO:0035634; GO:0050909; GO:0015912; GO:0034197","PTHR11923:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1663|UniProtKB=P16671"]
["CD44",null,"CD44","90-85","rb",null,1.1000000000000001,4,"n/a","n/a","n/a","n/a","# 0439",".ALZ., .APO., .CD., .CSP., .DDR., .DI., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .P53S., .RTK., .ST., .TCR.","Alzheimer disease-presenilin pathway","CD44 ANTIGEN","cartilage development; cell adhesion; cell migration; cell-cell adhesion; cell-matrix adhesion; cellular response to fibroblast growth factor stimulus; cytokine-mediated signaling pathway; hyaluronan catabolic process; inflammatory response; monocyte aggregation; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of ERK1 and ERK2 cascade; positive regulation of heterotypic cell-cell adhesion; positive regulation of monocyte aggregation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of lamellipodium morphogenesis; T cell activation; wound healing, spreading of cells","collagen binding; cytokine receptor activity; hyaluronic acid binding; protein binding; transmembrane signaling receptor activity","apical plasma membrane; basolateral plasma membrane; cell projection; cell surface; cytosol; extracellular exosome; focal adhesion; Golgi apparatus; lamellipodium membrane; macrophage migration inhibitory factor receptor complex; membrane; microvillus; plasma membrane; secretory granule membrane","Stem cell marker","CD44 molecule (Indian blood group)","http://www.ncbi.nlm.nih.gov/gene/?term=960","960","12505",null,null,null,"717204","P16070","A2APM1","A0A8I5ZKQ4","A0A8I3PG65","A0A5G2QN76","A0A1D5QRB0","GO:0016324; GO:0016323; GO:0042995; GO:0009986; GO:0005829; GO:0070062; GO:0005925; GO:0005794; GO:0031258; GO:0035692; GO:0016020; GO:0005902; GO:0005886; GO:0030667","GO:0005518; GO:0004896; GO:0005540; GO:0005515; GO:0004888","GO:0051216; GO:0007155; GO:0016477; GO:0098609; GO:0007160; GO:0044344; GO:0019221; GO:0030214; GO:0006954; GO:0070487; GO:0043066; GO:0043154; GO:0043518; GO:1902166; GO:0070374; GO:0034116; GO:1900625; GO:0033138; GO:0050731; GO:2000392; GO:0042110; GO:0044319","PTHR10225:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1681|UniProtKB=P16070","P00004"]
["CD44",null,"CD44","80","rb",null,2,8,"n/a","n/a","n/a","n/a","# 2792",".ALZ., .APO., .CD., .CSP., .DDR., .DI., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .P53S., .RTK., .ST., .TCR.","Alzheimer disease-presenilin pathway","CD44 ANTIGEN","cartilage development; cell adhesion; cell migration; cell-cell adhesion; cell-matrix adhesion; cellular response to fibroblast growth factor stimulus; cytokine-mediated signaling pathway; hyaluronan catabolic process; inflammatory response; monocyte aggregation; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of ERK1 and ERK2 cascade; positive regulation of heterotypic cell-cell adhesion; positive regulation of monocyte aggregation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of lamellipodium morphogenesis; T cell activation; wound healing, spreading of cells","collagen binding; cytokine receptor activity; hyaluronic acid binding; protein binding; transmembrane signaling receptor activity","apical plasma membrane; basolateral plasma membrane; cell projection; cell surface; cytosol; extracellular exosome; focal adhesion; Golgi apparatus; lamellipodium membrane; macrophage migration inhibitory factor receptor complex; membrane; microvillus; plasma membrane; secretory granule membrane","Stem cell marker","CD44 molecule (Indian blood group)","http://www.ncbi.nlm.nih.gov/gene/?term=960","960","12505",null,null,null,"717204","P16070","A2APM1","A0A8I5ZKQ4","A0A8I3PG65","A0A5G2QN76","A0A1D5QRB0","GO:0016324; GO:0016323; GO:0042995; GO:0009986; GO:0005829; GO:0070062; GO:0005925; GO:0005794; GO:0031258; GO:0035692; GO:0016020; GO:0005902; GO:0005886; GO:0030667","GO:0005518; GO:0004896; GO:0005540; GO:0005515; GO:0004888","GO:0051216; GO:0007155; GO:0016477; GO:0098609; GO:0007160; GO:0044344; GO:0019221; GO:0030214; GO:0006954; GO:0070487; GO:0043066; GO:0043154; GO:0043518; GO:1902166; GO:0070374; GO:0034116; GO:1900625; GO:0033138; GO:0050731; GO:2000392; GO:0042110; GO:0044319","PTHR10225:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1681|UniProtKB=P16070","P00004"]
["CD44 variant (Exon v6)",null,"CD44","82","ms",null,6,4,"n/a","n/a","n/a","n/a","# 0480",".ALZ., .APO., .CD., .CSP., .DDR., .DI., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .P53S., .RTK., .ST., .TCR.","Alzheimer disease-presenilin pathway","CD44 ANTIGEN","cartilage development; cell adhesion; cell migration; cell-cell adhesion; cell-matrix adhesion; cellular response to fibroblast growth factor stimulus; cytokine-mediated signaling pathway; hyaluronan catabolic process; inflammatory response; monocyte aggregation; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of ERK1 and ERK2 cascade; positive regulation of heterotypic cell-cell adhesion; positive regulation of monocyte aggregation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of lamellipodium morphogenesis; T cell activation; wound healing, spreading of cells","collagen binding; cytokine receptor activity; hyaluronic acid binding; protein binding; transmembrane signaling receptor activity","apical plasma membrane; basolateral plasma membrane; cell projection; cell surface; cytosol; extracellular exosome; focal adhesion; Golgi apparatus; lamellipodium membrane; macrophage migration inhibitory factor receptor complex; membrane; microvillus; plasma membrane; secretory granule membrane","Stem cell marker","CD44 molecule (Indian blood group)","http://www.ncbi.nlm.nih.gov/gene/?term=960","960","12505",null,null,null,"717204","P16070","A2APM1","A0A8I5ZKQ4","A0A8I3PG65","A0A5G2QN76","A0A1D5QRB0","GO:0016324; GO:0016323; GO:0042995; GO:0009986; GO:0005829; GO:0070062; GO:0005925; GO:0005794; GO:0031258; GO:0035692; GO:0016020; GO:0005902; GO:0005886; GO:0030667","GO:0005518; GO:0004896; GO:0005540; GO:0005515; GO:0004888","GO:0051216; GO:0007155; GO:0016477; GO:0098609; GO:0007160; GO:0044344; GO:0019221; GO:0030214; GO:0006954; GO:0070487; GO:0043066; GO:0043154; GO:0043518; GO:1902166; GO:0070374; GO:0034116; GO:1900625; GO:0033138; GO:0050731; GO:2000392; GO:0042110; GO:0044319","PTHR10225:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1681|UniProtKB=P16070","P00004"]
["CD51 (VNR alpha)",null,"ITGAV","125","ms",null,2,1.1000000000000001,1.1000000000000001,8,6,1.1000000000000001,"# 0501",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .IMUR., .INT., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .VIR.","CCKR signaling map; Integrin signalling pathway","INTEGRIN ALPHA-V","angiogenesis; apolipoprotein A-I-mediated signaling pathway; apoptotic cell clearance; blood vessel development; calcium ion transmembrane transport; cell adhesion; cell adhesion mediated by integrin; cell migration; cell-cell adhesion; cell-matrix adhesion; cell-substrate adhesion; endodermal cell differentiation; entry into host cell by a symbiont-containing vacuole; ERK1 and ERK2 cascade; extrinsic apoptotic signaling pathway in absence of ligand; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; negative chemotaxis; negative regulation of entry of bacterium into host cell; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of lipid storage; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor activity; negative regulation of macrophage derived foam cell differentiation; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of intracellular signal transduction; positive regulation of osteoblast proliferation; positive regulation of small GTPase mediated signal transduction; regulation of phagocytosis; regulation of transforming growth factor beta activation; substrate adhesion-dependent cell spreading; transforming growth factor beta production; vasculogenesis; viral entry into host cell","coreceptor activity; C-X3-C chemokine binding; extracellular matrix binding; extracellular matrix protein binding; fibroblast growth factor binding; fibronectin binding; insulin-like growth factor I binding; integrin binding; metal ion binding; neuregulin binding; opsonin binding; protease binding; protein binding; protein kinase C binding; signaling receptor binding; transforming growth factor beta binding; virus receptor activity; voltage-gated calcium channel activity","alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; alphav-beta3 integrin-PKCalpha complex; anchoring junction; cell surface; cytosol; external side of plasma membrane; extracellular exosome; filopodium membrane; focal adhesion; integrin alphav-beta3 complex; integrin alphav-beta5 complex; integrin alphav-beta6 complex; integrin alphav-beta8 complex; integrin complex; lamellipodium membrane; membrane; microvillus membrane; phagocytic vesicle; plasma membrane; ruffle membrane; specific granule membrane","Adhesion","integrin subunit alpha V","http://www.ncbi.nlm.nih.gov/gene/?term=3685","3685","16410",null,null,null,null,"P06756","P43406","A0A0G2JVZ6","A0A8P0NGG7","A0A5G2QRI5","F6QSK2","GO:0035868; GO:0035867; GO:0035866; GO:0070161; GO:0009986; GO:0005829; GO:0009897; GO:0070062; GO:0031527; GO:0005925; GO:0034683; GO:0034684; GO:0034685; GO:0034686; GO:0008305; GO:0031258; GO:0016020; GO:0031528; GO:0045335; GO:0005886; GO:0032587; GO:0035579","GO:0015026; GO:0019960; GO:0050840; GO:1990430; GO:0017134; GO:0001968; GO:0031994; GO:0005178; GO:0046872; GO:0038132; GO:0001846; GO:0002020; GO:0005515; GO:0005080; GO:0005102; GO:0050431; GO:0001618; GO:0005245","GO:0001525; GO:0038027; GO:0043277; GO:0001568; GO:0070588; GO:0007155; GO:0033627; GO:0016477; GO:0098609; GO:0007160; GO:0031589; GO:0035987; GO:0085017; GO:0070371; GO:0097192; GO:0034113; GO:0007229; GO:0050919; GO:2000536; GO:2001237; GO:0010888; GO:0032369; GO:0050748; GO:1905598; GO:0010745; GO:0045785; GO:0030335; GO:0008284; GO:0007204; GO:1902533; GO:0033690; GO:0051057; GO:0050764; GO:1901388; GO:0034446; GO:0071604; GO:0001570; GO:0046718","PTHR23220:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6150|UniProtKB=P06756","P06959; P00034"]
["CD9",null,"CD9","25","rb",null,2,1,"n/a","n/a","n/a","n/a","# 1973",".CCP., .CP., .MIG., .OP., .OT., .PLAT.",null,"CD9 ANTIGEN","cell adhesion; cell population proliferation; cellular response to low-density lipoprotein particle stimulus; fusion of sperm to egg plasma membrane involved in single fertilization; glial cell migration; myoblast fusion involved in skeletal muscle regeneration; negative regulation of cell population proliferation; negative regulation of platelet aggregation; paranodal junction assembly; platelet activation; receptor internalization; regulation of macrophage migration; single fertilization; sperm-egg recognition","integrin binding; protein binding","cell surface; clathrin-coated endocytic vesicle membrane; endocytic vesicle membrane; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; extracellular vesicle; focal adhesion; membrane; plasma membrane; platelet alpha granule membrane; protein-containing complex",null,"CD9 molecule","http://www.ncbi.nlm.nih.gov/gene/?term=928","928","12527","24936",null,null,"712262","P21926","P40240","P40241","A0A8P0SJI6","A0A5G2R5C9","F7GKZ6","GO:0009986; GO:0030669; GO:0030666; GO:0009897; GO:0070062; GO:0005576; GO:0005615; GO:1903561; GO:0005925; GO:0016020; GO:0005886; GO:0031092; GO:0032991","GO:0005178; GO:0005515","GO:0007155; GO:0008283; GO:0071404; GO:0007342; GO:0008347; GO:0014905; GO:0008285; GO:0090331; GO:0030913; GO:0030168; GO:0031623; GO:1905521; GO:0007338; GO:0035036","PTHR19282:SF163","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1709|UniProtKB=P21926"]
["CD96",null,"CD96","160, 100","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2818",".IMFR., .IMU., .IMUR., .OP., .OT., .TRASR.",null,"T-CELL SURFACE PROTEIN TACTILE","cell adhesion; cell-matrix adhesion; immune response; inflammatory response; negative regulation of natural killer cell cytokine production; negative regulation of type II interferon production; response to lipopolysaccharide",null,"cytoplasm; membrane; plasma membrane",null,"CD96 molecule","http://www.ncbi.nlm.nih.gov/gene/?term=10225","10225","84544","498079",null,null,null,"P40200","Q3U0X8","Q5BK49","A0A8P0SF62","A0A286ZIM2","A0A5F7ZHQ5","GO:0005737; GO:0016020; GO:0005886",null,"GO:0007155; GO:0007160; GO:0006955; GO:0006954; GO:0002728; GO:0032689; GO:0032496","PTHR15317:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16892|UniProtKB=P40200"]
["cdc25A (M-phase inducer phosphatase 1)",null,"CDC25A","59","rb",null,2,2,6,2,2.1,2.1,"# 0400",".CCP., .CCY., .CD., .CP., .CSP., .OP., .OPA., .P53S., .ST.","p53 pathway","M-PHASE INDUCER PHOSPHATASE 1","cell cycle; cell division; cell population proliferation; cellular response to UV; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; positive regulation of cell cycle G2/M phase transition; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; protein dephosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; response to radiation","chaperone binding; hydrolase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity","cytoplasm; cytosol; nucleoplasm; nucleus","Cell cycle control","cell division cycle 25A","http://www.ncbi.nlm.nih.gov/gene/?term=993","993","12530",null,null,null,"710858","P30304","P48964","A0A8I5ZUR1","A0A8I3N5L5","A0A287B2P5","A0A1D5QME8","GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0051087; GO:0016787; GO:0004721; GO:0005515; GO:0019901; GO:0004725","GO:0007049; GO:0051301; GO:0008283; GO:0034644; GO:0000082; GO:0000086; GO:1902751; GO:0010971; GO:0110032; GO:0006470; GO:0000079; GO:0009314","PTHR10828:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1725|UniProtKB=P30304","P00059"]
["cdc25A (M-phase inducer phosphatase 1) - phospho","Ser75","CDC25A","59","rb",null,2,2,6,6,4,4,"# 0401",".CCP., .CCY., .CD., .CP., .CSP., .OP., .OPA., .P53S., .ST.","p53 pathway","M-PHASE INDUCER PHOSPHATASE 1","cell cycle; cell division; cell population proliferation; cellular response to UV; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; positive regulation of cell cycle G2/M phase transition; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; protein dephosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; response to radiation","chaperone binding; hydrolase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity","cytoplasm; cytosol; nucleoplasm; nucleus","Cell cycle control","cell division cycle 25A","http://www.ncbi.nlm.nih.gov/gene/?term=993","993","12530",null,null,null,"710858","P30304","P48964","A0A8I5ZUR1","A0A8I3N5L5","A0A287B2P5","A0A1D5QME8","GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0051087; GO:0016787; GO:0004721; GO:0005515; GO:0019901; GO:0004725","GO:0007049; GO:0051301; GO:0008283; GO:0034644; GO:0000082; GO:0000086; GO:1902751; GO:0010971; GO:0110032; GO:0006470; GO:0000079; GO:0009314","PTHR10828:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1725|UniProtKB=P30304","P00059"]
["cdc25B",null,"CDC25B","65","gt",null,2,2,2,2,2,2,"# 0490",".CCP., .CCY., .CP., .CSP., .MAPK., .OP., .OPA., .RTK., .ST.",null,"M-PHASE INDUCER PHOSPHATASE 2","cell cycle; cell division; female meiosis I; G2/M transition of mitotic cell cycle; mitotic cell cycle; oocyte maturation; positive regulation of cell cycle G2/M phase transition; positive regulation of cell population proliferation; positive regulation of cytokinesis; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; positive regulation of mitotic cell cycle; positive regulation of protein kinase activity; protein dephosphorylation; protein phosphorylation","hydrolase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity","centrosome; cytoplasm; cytoskeleton; cytosol; microtubule organizing center; nucleoplasm; nucleus; spindle pole","Cell cycle control","cell division cycle 25B","http://www.ncbi.nlm.nih.gov/gene/?term=994","994","12531",null,null,"100329127",null,"P30305","P30306","A0A8I6A7K8","A0A8I3NSJ2","A0A287B203","A0A1D5Q323","GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0005815; GO:0005654; GO:0005634; GO:0000922","GO:0016787; GO:0004721; GO:0005515; GO:0019901; GO:0004725","GO:0007049; GO:0051301; GO:0007144; GO:0000086; GO:0000278; GO:0001556; GO:1902751; GO:0008284; GO:0032467; GO:0010971; GO:0110032; GO:0045931; GO:0045860; GO:0006470; GO:0006468","PTHR10828:SF48","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1726|UniProtKB=P30305"]
["cdc25C",null,"CDC25C","60","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0236",".CCP., .CCY., .CD., .CP., .CSP., .OP., .OPA., .P53S., .ST.","p53 pathway","M-PHASE INDUCER PHOSPHATASE 3","cell cycle; cell division; cell population proliferation; G2/M transition of mitotic cell cycle; positive regulation of cell cycle G2/M phase transition; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; protein dephosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic nuclear division; spermatogenesis","hydrolase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; WW domain binding","cytoplasm; cytosol; mitochondrial intermembrane space; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm","Cell cycle control","cell division cycle 25C","http://www.ncbi.nlm.nih.gov/gene/?term=995","995","12532","307511",null,null,"714115","P30307","P48967","D4ADT2","A0A8I3P6X2","F1RH78","F7FH10","GO:0005737; GO:0005829; GO:0005758; GO:0016607; GO:0005654; GO:0005634; GO:0048471","GO:0016787; GO:0004721; GO:0005515; GO:0019901; GO:0004725; GO:0050699","GO:0007049; GO:0051301; GO:0008283; GO:0000086; GO:1902751; GO:0010971; GO:0110032; GO:0006470; GO:0000079; GO:0007088; GO:0007283","PTHR10828:SF64","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1727|UniProtKB=P30307","P00059"]
["cdc27",null,"CDC27","97","ms",null,2,4,1.1000000000000001,4,4,4,"# 0508",".CCP., .CCY., .CP., .OP., .OT., .UBI.",null,"CELL DIVISION CYCLE PROTEIN 27 HOMOLOG","anaphase-promoting complex-dependent catabolic process; cell division; metaphase/anaphase transition of mitotic cell cycle; positive regulation of mitotic metaphase/anaphase transition; protein K11-linked ubiquitination; protein ubiquitination; regulation of meiotic cell cycle; regulation of mitotic cell cycle","protein binding; protein phosphatase binding","anaphase-promoting complex; centrosome; cytoplasm; cytoskeleton; cytosol; mitotic spindle; nucleoplasm; nucleus; spindle","Cell cycle control","cell division cycle 27","http://www.ncbi.nlm.nih.gov/gene/?term=996","996","217232",null,null,null,null,"P30260","A2A6Q5","A0A8I5ZLM4","A0A8P0NFP8","A0A287A5X1","A0A1D5RA01","GO:0005680; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0072686; GO:0005654; GO:0005634; GO:0005819","GO:0005515; GO:0019903","GO:0031145; GO:0051301; GO:0007091; GO:0045842; GO:0070979; GO:0016567; GO:0051445; GO:0007346","PTHR12558:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1728|UniProtKB=P30260"]
["cdc37 (p50Cdc37, HSP 90 chaperone protein kinase-targeting subunit)",null,"CDC37","45","rb",null,1,2,1,1,1,2,"# 0411",".APH., .CD., .CSP., .CUR., .D300., .DAKT., .IMUF., .INFG., .INFM., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.",null,"HSP90 CO-CHAPERONE CDC37","positive regulation of mitophagy in response to mitochondrial depolarization; post-transcriptional regulation of gene expression; protein folding; protein stabilization; protein targeting; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of protein kinase activity; regulation of type I interferon-mediated signaling pathway; regulation of type II interferon-mediated signaling pathway","chaperone binding; heat shock protein binding; Hsp90 protein binding; kinase binding; protein binding; protein kinase binding; protein kinase regulator activity; scaffold protein binding; unfolded protein binding","chaperone complex; cytoplasm; cytosol; extracellular exosome; HSP90-CDC37 chaperone complex","Cell cycle control","cell division cycle 37, HSP90 cochaperone","http://www.ncbi.nlm.nih.gov/gene/?term=11140","11140","12539",null,"484955",null,"715390","Q16543","Q61081","A0A0G2K3C1","A0A8I3PXI0","A0A5G2R4U3","A0A1D5RA77","GO:0101031; GO:0005737; GO:0005829; GO:0070062; GO:1990565","GO:0051087; GO:0031072; GO:0051879; GO:0019900; GO:0005515; GO:0019901; GO:0019887; GO:0097110; GO:0051082","GO:0098779; GO:0010608; GO:0006457; GO:0050821; GO:0006605; GO:0000079; GO:0045859; GO:0060338; GO:0060334","PTHR12800:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1735|UniProtKB=Q16543"]
["cdc6",null,"CDC6","62","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1581",".CCP., .CCY., .CP., .OP.",null,"CELL DIVISION CONTROL PROTEIN 6 HOMOLOG","cell cycle; cell division; cellular response to angiotensin; cellular response to vasopressin; DNA replication; DNA replication checkpoint signaling; DNA replication initiation; mitotic cell cycle; mitotic DNA replication checkpoint signaling; negative regulation of cell population proliferation; negative regulation of DNA replication; positive regulation of chromosome segregation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of cytokinesis; positive regulation of fibroblast proliferation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic metaphase/anaphase transition; traversing start control point of mitotic cell cycle","ATP binding; DNA replication origin binding; kinase binding; nucleotide binding; protein binding","cytoplasm; cytosol; intercellular bridge; mitotic spindle; nucleolus; nucleoplasm; nucleus; spindle midzone; spindle pole","Cell cycle control","cell division cycle 6","http://www.ncbi.nlm.nih.gov/gene/?term=990","990","23834","360621","480527","100522031",null,"Q99741","O89033","D3ZRK7","A0A8I3N5S4","F1RXE3","A0A5F7ZHE6","GO:0005737; GO:0005829; GO:0045171; GO:0072686; GO:0005730; GO:0005654; GO:0005634; GO:0051233; GO:0000922","GO:0005524; GO:0003688; GO:0019900; GO:0000166; GO:0005515","GO:0007049; GO:0051301; GO:1904385; GO:1904117; GO:0006260; GO:0000076; GO:0006270; GO:0000278; GO:0033314; GO:0008285; GO:0008156; GO:0051984; GO:0045737; GO:0032467; GO:0048146; GO:0000079; GO:0030071; GO:0007089","PTHR10763:SF26","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1744|UniProtKB=Q99741"]
["CDK substrates - phospho","Ser","CDK1","n.a.","rb",null,"n/a","n/a","n/a","n/a","n/a","n/a","# 3133",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .DRR., .IMUR., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .P53S., .RTK., .SREME., .ST., .TRASR., .UBI., .VIR.","p53 pathway","CYCLIN-DEPENDENT KINASE 1","animal organ regeneration; apoptotic process; cell cycle; cell division; cell migration; cellular response to hydrogen peroxide; cellular response to organic cyclic compound; centrosome cycle; chromosome condensation; DNA repair; DNA replication; epithelial cell differentiation; ERK1 and ERK2 cascade; fibroblast proliferation; G2/M transition of mitotic cell cycle; Golgi disassembly; histone modification; microtubule cytoskeleton organization; mitotic cell cycle; mitotic cell cycle phase transition; mitotic G2 DNA damage checkpoint signaling; negative regulation of apoptotic process; negative regulation of gene expression; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of DNA replication; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; positive regulation of protein import into nucleus; positive regulation of protein localization to nucleus; pronuclear fusion; protein deubiquitination; protein localization to kinetochore; protein phosphorylation; protein-containing complex assembly; regulation of circadian rhythm; regulation of embryonic development; regulation of Schwann cell differentiation; response to activity; response to amine; response to axon injury; response to cadmium ion; response to copper ion; response to ethanol; response to hydrogen peroxide; response to organic cyclic compound; response to organonitrogen compound; response to toxic substance; response to xenobiotic stimulus; rhythmic process; ventricular cardiac muscle cell development; viral entry into host cell","ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; histone kinase activity; Hsp70 protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity; virus receptor activity","centrosome; chromosome, telomeric region; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum membrane; extracellular exosome; membrane; microtubule organizing center; midbody; mitochondrial matrix; mitochondrion; mitotic spindle; nucleoplasm; nucleus; spindle; spindle microtubule","Cell cycle control","cyclin dependent kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=983","983","12534","54237",null,null,null,"P06493","P11440","P39951","A0A8I3MIX3","A0A287A6N5","F7EBT6","GO:0005813; GO:0000781; GO:0097125; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0005789; GO:0070062; GO:0016020; GO:0005815; GO:0030496; GO:0005759; GO:0005739; GO:0072686; GO:0005654; GO:0005634; GO:0005819; GO:0005876","GO:0005524; GO:0003682; GO:0030332; GO:0097472; GO:0004693; GO:0035173; GO:0030544; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0008353; GO:0016740; GO:0001618","GO:0031100; GO:0006915; GO:0007049; GO:0051301; GO:0016477; GO:0070301; GO:0071407; GO:0007098; GO:0030261; GO:0006281; GO:0006260; GO:0030855; GO:0070371; GO:0048144; GO:0000086; GO:0090166; GO:0016570; GO:0000226; GO:0000278; GO:0044772; GO:0007095; GO:0043066; GO:0010629; GO:0018105; GO:0018107; GO:0016310; GO:0060045; GO:0045740; GO:0010971; GO:0010628; GO:1905448; GO:0045931; GO:0042307; GO:1900182; GO:0007344; GO:0016579; GO:0034501; GO:0006468; GO:0065003; GO:0042752; GO:0045995; GO:0014038; GO:0014823; GO:0014075; GO:0048678; GO:0046686; GO:0046688; GO:0045471; GO:0042542; GO:0014070; GO:0010243; GO:0009636; GO:0009410; GO:0048511; GO:0055015; GO:0046718","PTHR24056:SF334","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1722|UniProtKB=P06493","P00059"]
["CDK1 (cdc2 )",null,"CDK1","34","ms",null,1,1,"n/a","n/a","n/a","n/a","# 1010",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .DRR., .IMUR., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .P53S., .RTK., .SREME., .ST., .TRASR., .UBI., .VIR.","p53 pathway","CYCLIN-DEPENDENT KINASE 1","animal organ regeneration; apoptotic process; cell cycle; cell division; cell migration; cellular response to hydrogen peroxide; cellular response to organic cyclic compound; centrosome cycle; chromosome condensation; DNA repair; DNA replication; epithelial cell differentiation; ERK1 and ERK2 cascade; fibroblast proliferation; G2/M transition of mitotic cell cycle; Golgi disassembly; histone modification; microtubule cytoskeleton organization; mitotic cell cycle; mitotic cell cycle phase transition; mitotic G2 DNA damage checkpoint signaling; negative regulation of apoptotic process; negative regulation of gene expression; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of DNA replication; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; positive regulation of protein import into nucleus; positive regulation of protein localization to nucleus; pronuclear fusion; protein deubiquitination; protein localization to kinetochore; protein phosphorylation; protein-containing complex assembly; regulation of circadian rhythm; regulation of embryonic development; regulation of Schwann cell differentiation; response to activity; response to amine; response to axon injury; response to cadmium ion; response to copper ion; response to ethanol; response to hydrogen peroxide; response to organic cyclic compound; response to organonitrogen compound; response to toxic substance; response to xenobiotic stimulus; rhythmic process; ventricular cardiac muscle cell development; viral entry into host cell","ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; histone kinase activity; Hsp70 protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity; virus receptor activity","centrosome; chromosome, telomeric region; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum membrane; extracellular exosome; membrane; microtubule organizing center; midbody; mitochondrial matrix; mitochondrion; mitotic spindle; nucleoplasm; nucleus; spindle; spindle microtubule","Cell cycle control","cyclin dependent kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=983","983","12534","54237",null,null,null,"P06493","P11440","P39951","A0A8I3MIX3","A0A287A6N5","F7EBT6","GO:0005813; GO:0000781; GO:0097125; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0005789; GO:0070062; GO:0016020; GO:0005815; GO:0030496; GO:0005759; GO:0005739; GO:0072686; GO:0005654; GO:0005634; GO:0005819; GO:0005876","GO:0005524; GO:0003682; GO:0030332; GO:0097472; GO:0004693; GO:0035173; GO:0030544; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0008353; GO:0016740; GO:0001618","GO:0031100; GO:0006915; GO:0007049; GO:0051301; GO:0016477; GO:0070301; GO:0071407; GO:0007098; GO:0030261; GO:0006281; GO:0006260; GO:0030855; GO:0070371; GO:0048144; GO:0000086; GO:0090166; GO:0016570; GO:0000226; GO:0000278; GO:0044772; GO:0007095; GO:0043066; GO:0010629; GO:0018105; GO:0018107; GO:0016310; GO:0060045; GO:0045740; GO:0010971; GO:0010628; GO:1905448; GO:0045931; GO:0042307; GO:1900182; GO:0007344; GO:0016579; GO:0034501; GO:0006468; GO:0065003; GO:0042752; GO:0045995; GO:0014038; GO:0014823; GO:0014075; GO:0048678; GO:0046686; GO:0046688; GO:0045471; GO:0042542; GO:0014070; GO:0010243; GO:0009636; GO:0009410; GO:0048511; GO:0055015; GO:0046718","PTHR24056:SF334","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1722|UniProtKB=P06493","P00059"]
["CDK1 (cdc2 ) - phospho","Tyr15","CDK1","34","rb",null,1,4,4,4,4,4,"# 2678",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .DRR., .IMUR., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .P53S., .RTK., .SREME., .ST., .TRASR., .UBI., .VIR.","p53 pathway","CYCLIN-DEPENDENT KINASE 1","animal organ regeneration; apoptotic process; cell cycle; cell division; cell migration; cellular response to hydrogen peroxide; cellular response to organic cyclic compound; centrosome cycle; chromosome condensation; DNA repair; DNA replication; epithelial cell differentiation; ERK1 and ERK2 cascade; fibroblast proliferation; G2/M transition of mitotic cell cycle; Golgi disassembly; histone modification; microtubule cytoskeleton organization; mitotic cell cycle; mitotic cell cycle phase transition; mitotic G2 DNA damage checkpoint signaling; negative regulation of apoptotic process; negative regulation of gene expression; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of DNA replication; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; positive regulation of protein import into nucleus; positive regulation of protein localization to nucleus; pronuclear fusion; protein deubiquitination; protein localization to kinetochore; protein phosphorylation; protein-containing complex assembly; regulation of circadian rhythm; regulation of embryonic development; regulation of Schwann cell differentiation; response to activity; response to amine; response to axon injury; response to cadmium ion; response to copper ion; response to ethanol; response to hydrogen peroxide; response to organic cyclic compound; response to organonitrogen compound; response to toxic substance; response to xenobiotic stimulus; rhythmic process; ventricular cardiac muscle cell development; viral entry into host cell","ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; histone kinase activity; Hsp70 protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity; virus receptor activity","centrosome; chromosome, telomeric region; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum membrane; extracellular exosome; membrane; microtubule organizing center; midbody; mitochondrial matrix; mitochondrion; mitotic spindle; nucleoplasm; nucleus; spindle; spindle microtubule","Cell cycle control","cyclin dependent kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=983","983","12534","54237",null,null,null,"P06493","P11440","P39951","A0A8I3MIX3","A0A287A6N5","F7EBT6","GO:0005813; GO:0000781; GO:0097125; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0005789; GO:0070062; GO:0016020; GO:0005815; GO:0030496; GO:0005759; GO:0005739; GO:0072686; GO:0005654; GO:0005634; GO:0005819; GO:0005876","GO:0005524; GO:0003682; GO:0030332; GO:0097472; GO:0004693; GO:0035173; GO:0030544; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0008353; GO:0016740; GO:0001618","GO:0031100; GO:0006915; GO:0007049; GO:0051301; GO:0016477; GO:0070301; GO:0071407; GO:0007098; GO:0030261; GO:0006281; GO:0006260; GO:0030855; GO:0070371; GO:0048144; GO:0000086; GO:0090166; GO:0016570; GO:0000226; GO:0000278; GO:0044772; GO:0007095; GO:0043066; GO:0010629; GO:0018105; GO:0018107; GO:0016310; GO:0060045; GO:0045740; GO:0010971; GO:0010628; GO:1905448; GO:0045931; GO:0042307; GO:1900182; GO:0007344; GO:0016579; GO:0034501; GO:0006468; GO:0065003; GO:0042752; GO:0045995; GO:0014038; GO:0014823; GO:0014075; GO:0048678; GO:0046686; GO:0046688; GO:0045471; GO:0042542; GO:0014070; GO:0010243; GO:0009636; GO:0009410; GO:0048511; GO:0055015; GO:0046718","PTHR24056:SF334","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1722|UniProtKB=P06493","P00059"]
["CDK12",null,"CDK12","205","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1460",".CCP., .CCY., .CSP., .OP., .OPA., .OT., .ST., .TRASR.",null,"CYCLIN-DEPENDENT KINASE 12","mRNA processing; negative regulation of stem cell differentiation; phosphorylation; phosphorylation of RNA polymerase II C-terminal domain; positive regulation of transcription elongation by RNA polymerase II; protein autophosphorylation; protein phosphorylation; regulation of cell cycle; regulation of MAP kinase activity; regulation of RNA splicing; RNA splicing; transcription by RNA polymerase II; transcription elongation by RNA polymerase II","ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity","cyclin K-CDK12 complex; cyclin/CDK positive transcription elongation factor complex; cyclin-dependent protein kinase holoenzyme complex; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleoplasm; nucleus","Cell cycle control","cyclin dependent kinase 12","http://www.ncbi.nlm.nih.gov/gene/?term=51755","51755","69131",null,"491027",null,null,"Q9NYV4","Q14AX6","A0A0G2K5U7","A0A8I3NMP8","A0A287ADU9","F7DGS7","GO:0002944; GO:0008024; GO:0000307; GO:0019908; GO:0016607; GO:0005654; GO:0005634","GO:0005524; GO:0030332; GO:0004693; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0008353; GO:0016740","GO:0006397; GO:2000737; GO:0016310; GO:0070816; GO:0032968; GO:0046777; GO:0006468; GO:0051726; GO:0043405; GO:0043484; GO:0008380; GO:0006366; GO:0006368","PTHR24056:SF126","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24224|UniProtKB=Q9NYV4"]
["CDK2",null,"CDK2","33","rb",null,1,2.1,4,4,1.1000000000000001,4,"# 2057",".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DREP., .FOXO., .HEPB., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RAS., .RTK., .SCLC., .ST., .TRASR.","p53 pathway; p53 pathway feedback loops 2","CYCLIN-DEPENDENT KINASE 2","cell cycle; cell division; cellular response to DNA damage stimulus; cellular response to nitric oxide; cellular senescence; centriole replication; centrosome duplication; DNA repair; DNA replication; DNA-templated transcription; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; histone modification; meiotic cell cycle; mitotic G1 DNA damage checkpoint signaling; negative regulation of transcription by RNA polymerase II; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell population proliferation; positive regulation of DNA-templated DNA replication initiation; positive regulation of DNA-templated transcription; positive regulation of heterochromatin formation; post-translational protein modification; potassium ion transport; protein phosphorylation; Ras protein signal transduction; regulation of anaphase-promoting complex-dependent catabolic process; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; signal transduction","ATP binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; histone kinase activity; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein domain specific binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","Cajal body; centrosome; chromosome, telomeric region; condensed chromosome; cyclin A1-CDK2 complex; cyclin A2-CDK2 complex; cyclin E1-CDK2 complex; cyclin E2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; endosome; male germ cell nucleus; microtubule organizing center; nucleoplasm; nucleus; transcription regulator complex; X chromosome; Y chromosome","Cell cycle control","cyclin dependent kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=1017","1017","12566","362817","100855704",null,null,"P24941","P97377","A0A8I6AHN8","A0A8I3MY98",null,null,"GO:0015030; GO:0005813; GO:0000781; GO:0000793; GO:0097123; GO:0097124; GO:0097134; GO:0097135; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0005768; GO:0001673; GO:0005815; GO:0005654; GO:0005634; GO:0005667; GO:0000805; GO:0000806","GO:0005524; GO:0030332; GO:0097472; GO:0004693; GO:0035173; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0019904; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0051301; GO:0006974; GO:0071732; GO:0090398; GO:0007099; GO:0051298; GO:0006281; GO:0006260; GO:0006351; GO:0000082; GO:0000086; GO:0016570; GO:0051321; GO:0031571; GO:0000122; GO:0018105; GO:0016310; GO:0008284; GO:0032298; GO:0045893; GO:0031453; GO:0043687; GO:0006813; GO:0006468; GO:0007265; GO:1905784; GO:0010389; GO:0010468; GO:0007165","PTHR24056:SF521","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1771|UniProtKB=P24941","P00059; P04398"]
["CDK2 - phospho","Thr160","CDK2","33","rb",null,2,2.1,4,4,4,4,"# 2157",".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DREP., .FOXO., .HEPB., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RAS., .RTK., .SCLC., .ST., .TRASR.","p53 pathway; p53 pathway feedback loops 2","CYCLIN-DEPENDENT KINASE 2","cell cycle; cell division; cellular response to DNA damage stimulus; cellular response to nitric oxide; cellular senescence; centriole replication; centrosome duplication; DNA repair; DNA replication; DNA-templated transcription; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; histone modification; meiotic cell cycle; mitotic G1 DNA damage checkpoint signaling; negative regulation of transcription by RNA polymerase II; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell population proliferation; positive regulation of DNA-templated DNA replication initiation; positive regulation of DNA-templated transcription; positive regulation of heterochromatin formation; post-translational protein modification; potassium ion transport; protein phosphorylation; Ras protein signal transduction; regulation of anaphase-promoting complex-dependent catabolic process; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; signal transduction","ATP binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; histone kinase activity; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein domain specific binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","Cajal body; centrosome; chromosome, telomeric region; condensed chromosome; cyclin A1-CDK2 complex; cyclin A2-CDK2 complex; cyclin E1-CDK2 complex; cyclin E2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; endosome; male germ cell nucleus; microtubule organizing center; nucleoplasm; nucleus; transcription regulator complex; X chromosome; Y chromosome","Cell cycle control","cyclin dependent kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=1017","1017","12566","362817","100855704",null,null,"P24941","P97377","A0A8I6AHN8","A0A8I3MY98",null,null,"GO:0015030; GO:0005813; GO:0000781; GO:0000793; GO:0097123; GO:0097124; GO:0097134; GO:0097135; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0005768; GO:0001673; GO:0005815; GO:0005654; GO:0005634; GO:0005667; GO:0000805; GO:0000806","GO:0005524; GO:0030332; GO:0097472; GO:0004693; GO:0035173; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0019904; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0051301; GO:0006974; GO:0071732; GO:0090398; GO:0007099; GO:0051298; GO:0006281; GO:0006260; GO:0006351; GO:0000082; GO:0000086; GO:0016570; GO:0051321; GO:0031571; GO:0000122; GO:0018105; GO:0016310; GO:0008284; GO:0032298; GO:0045893; GO:0031453; GO:0043687; GO:0006813; GO:0006468; GO:0007265; GO:1905784; GO:0010389; GO:0010468; GO:0007165","PTHR24056:SF521","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1771|UniProtKB=P24941","P00059; P04398"]
["CDK3",null,"CDK3","35","rb",null,2,2,2,2,2,2,"# 1273",".CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .NOTCH., .OP., .OPA., .ST.",null,"CYCLIN-DEPENDENT KINASE 3","cell cycle; cell division; cell population proliferation; cellular response to DNA damage stimulus; G0 to G1 transition; G1/S transition of mitotic cell cycle; negative regulation of Notch signaling pathway; phosphorylation; protein phosphorylation; regulation of cell cycle","ATP binding; cyclin-dependent protein serine/threonine kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cyclin-dependent protein kinase holoenzyme complex; nucleus","Cell cycle control","cyclin dependent kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=1018","1018",null,null,null,"100520449",null,"Q00526",null,null,"A0A8I3PLD8","F1RW05","F7FIM6","GO:0000307; GO:0005634","GO:0005524; GO:0004693; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0051301; GO:0008283; GO:0006974; GO:0045023; GO:0000082; GO:0045746; GO:0016310; GO:0006468; GO:0051726","PTHR24056:SF462","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1772|UniProtKB=Q00526"]
["CDK4",null,"CDK4","30","ms",null,1,2,2.1,1,8,8,"# 1272",".BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DRR., .GLI., .IMUF., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .RTK., .SCLC., .SREME., .ST., .TCR., .TRASR.",null,"CYCLIN-DEPENDENT KINASE 4","adipose tissue development; cell cycle; cell division; cellular response to insulin stimulus; cellular response to interleukin-4; cellular response to ionomycin; cellular response to lipopolysaccharide; cellular response to phorbol 13-acetate 12-myristate; G1/S transition of mitotic cell cycle; phosphorylation; positive regulation of cell population proliferation; positive regulation of fibroblast proliferation; positive regulation of G2/M transition of mitotic cell cycle; protein phosphorylation; regulation of cell cycle; regulation of gene expression; regulation of insulin receptor signaling pathway; regulation of lipid biosynthetic process; regulation of lipid catabolic process; regulation of multicellular organism growth; regulation of transcription initiation by RNA polymerase II; regulation of type B pancreatic cell proliferation; response to xenobiotic stimulus; signal transduction","ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","bicellular tight junction; chromatin; cyclin D1-CDK4 complex; cyclin D2-CDK4 complex; cyclin D3-CDK4 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; mediator complex; membrane; nuclear membrane; nucleolus; nucleoplasm; nucleus; protein-containing complex; transcription regulator complex","Cell cycle control","cyclin dependent kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=1019","1019","12567",null,"481131","100144492",null,"P11802","P30285","A0A8I5ZNF8","A0A8I3NU36","P79432","A0A1D5QJW2","GO:0005923; GO:0000785; GO:0097128; GO:0097129; GO:0097130; GO:0000307; GO:0005737; GO:0005829; GO:0016592; GO:0016020; GO:0031965; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0005667","GO:0005524; GO:0030332; GO:0004693; GO:0016538; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0060612; GO:0007049; GO:0051301; GO:0032869; GO:0071353; GO:1904637; GO:0071222; GO:1904628; GO:0000082; GO:0016310; GO:0008284; GO:0048146; GO:0010971; GO:0006468; GO:0051726; GO:0010468; GO:0046626; GO:0046890; GO:0050994; GO:0040014; GO:0060260; GO:0061469; GO:0009410; GO:0007165","PTHR24056:SF129","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1773|UniProtKB=P11802"]
["CDK4",null,"CDK4","30","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2460",".BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DRAS., .DRR., .GLI., .IMUF., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .RTK., .SCLC., .SREME., .ST., .TCR., .TRASR.",null,"CYCLIN-DEPENDENT KINASE 4","adipose tissue development; cell cycle; cell division; cellular response to insulin stimulus; cellular response to interleukin-4; cellular response to ionomycin; cellular response to lipopolysaccharide; cellular response to phorbol 13-acetate 12-myristate; G1/S transition of mitotic cell cycle; phosphorylation; positive regulation of cell population proliferation; positive regulation of fibroblast proliferation; positive regulation of G2/M transition of mitotic cell cycle; protein phosphorylation; regulation of cell cycle; regulation of gene expression; regulation of insulin receptor signaling pathway; regulation of lipid biosynthetic process; regulation of lipid catabolic process; regulation of multicellular organism growth; regulation of transcription initiation by RNA polymerase II; regulation of type B pancreatic cell proliferation; response to xenobiotic stimulus; signal transduction","ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","bicellular tight junction; chromatin; cyclin D1-CDK4 complex; cyclin D2-CDK4 complex; cyclin D3-CDK4 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; mediator complex; membrane; nuclear membrane; nucleolus; nucleoplasm; nucleus; protein-containing complex; transcription regulator complex","Cell cycle control","cyclin dependent kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=1019","1019","12567",null,"481131","100144492",null,"P11802","P30285","A0A8I5ZNF8","A0A8I3NU36","P79432","A0A1D5QJW2","GO:0005923; GO:0000785; GO:0097128; GO:0097129; GO:0097130; GO:0000307; GO:0005737; GO:0005829; GO:0016592; GO:0016020; GO:0031965; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0005667","GO:0005524; GO:0030332; GO:0004693; GO:0016538; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0060612; GO:0007049; GO:0051301; GO:0032869; GO:0071353; GO:1904637; GO:0071222; GO:1904628; GO:0000082; GO:0016310; GO:0008284; GO:0048146; GO:0010971; GO:0006468; GO:0051726; GO:0010468; GO:0046626; GO:0046890; GO:0050994; GO:0040014; GO:0060260; GO:0061469; GO:0009410; GO:0007165","PTHR24056:SF129","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1773|UniProtKB=P11802"]
["CDK5",null,"CDK5","30","rb",null,2,2,2,1,1,2,"# 1478",".ALZ., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .DI., .MIG., .OP., .OPA., .OT., .P53S., .RTK., .ST., .STAT., .TRASR., .UBI.","Nicotine pharmacodynamics pathway; p53 pathway; Dopamine receptor mediated signaling pathway; Axon guidance mediated by semaphorins","CYCLIN-DEPENDENT-LIKE KINASE 5","apoptotic process; associative learning; axon extension; axonogenesis; behavioral response to cocaine; calcium ion import; cell cycle; cell division; cell migration; cell-matrix adhesion; cellular response to amyloid-beta; central nervous system neuron development; cerebellar cortex development; cerebellar cortex formation; cerebellum development; cerebral cortex development; chemical synaptic transmission; corpus callosum development; cortical actin cytoskeleton organization; dendrite morphogenesis; establishment of localization in cell; excitatory postsynaptic potential; exocytosis; forebrain development; hippocampus development; histone modification; intracellular protein transport; layer formation in cerebral cortex; microtubule cytoskeleton organization; mitochondrion organization; motor neuron axon guidance; negative regulation of axon extension; negative regulation of cell cycle; negative regulation of DNA-templated transcription; negative regulation of neuron death; negative regulation of protein export from nucleus; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of synaptic plasticity; nervous system development; neuron apoptotic process; neuron differentiation; neuron migration; neuron projection development; neuron projection morphogenesis; nucleocytoplasmic transport; oligodendrocyte differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of calcium ion-dependent exocytosis; positive regulation of glial cell apoptotic process; positive regulation of neuron apoptotic process; positive regulation of neuron death; positive regulation of presynaptic cytosolic calcium concentration; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of voltage-gated calcium channel activity; protein autophosphorylation; protein localization to synapse; protein phosphorylation; receptor catabolic process; receptor clustering; regulated exocytosis; regulation of apoptotic process; regulation of cell cycle; regulation of cell migration; regulation of dendritic spine morphogenesis; regulation of macroautophagy; regulation of postsynaptic membrane potential; regulation of presynaptic cytosolic calcium ion concentration; regulation of protein localization to plasma membrane; regulation of synapse pruning; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle recycling; regulation of transcription involved in G1/S transition of mitotic cell cycle; response to cocaine; response to wounding; rhythmic process; Schwann cell development; sensory perception of pain; serine phosphorylation of STAT protein; skeletal muscle tissue development; synapse assembly; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synaptic vesicle transport; telencephalon development; visual learning","acetylcholine receptor activator activity; ATP binding; cyclin-dependent protein serine/threonine kinase activity; cytoskeletal protein binding; ephrin receptor binding; ErbB-2 class receptor binding; ErbB-3 class receptor binding; histone kinase activity; Hsp90 protein binding; kinase activity; microtubule binding; nucleotide binding; p53 binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity; transferase activity","axon; cell junction; cell projection; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; dendrite; filopodium; glutamatergic synapse; growth cone; lamellipodium; membrane; microtubule; neuromuscular junction; neuron projection; neuronal cell body; nucleoplasm; nucleus; perikaryon; plasma membrane; postsynapse; postsynaptic density; presynapse; protein kinase 5 complex; Schaffer collateral - CA1 synapse; synapse","Cell cycle control","cyclin dependent kinase 5","http://www.ncbi.nlm.nih.gov/gene/?term=1020","1020","12568",null,null,null,null,"Q00535","P49615","A0A8I5Y6S3","A0A8I3N100","A0A5G2R8T5",null,"GO:0030424; GO:0030054; GO:0042995; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0030175; GO:0098978; GO:0030426; GO:0030027; GO:0016020; GO:0005874; GO:0031594; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0043204; GO:0005886; GO:0098794; GO:0014069; GO:0098793; GO:0016533; GO:0098685; GO:0045202","GO:0030549; GO:0005524; GO:0004693; GO:0008092; GO:0046875; GO:0005176; GO:0043125; GO:0035173; GO:0051879; GO:0016301; GO:0008017; GO:0000166; GO:0002039; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0048156; GO:0050321; GO:0016740","GO:0006915; GO:0008306; GO:0048675; GO:0007409; GO:0048148; GO:0070509; GO:0007049; GO:0051301; GO:0016477; GO:0007160; GO:1904646; GO:0021954; GO:0021695; GO:0021697; GO:0021549; GO:0021987; GO:0007268; GO:0022038; GO:0030866; GO:0048813; GO:0051649; GO:0060079; GO:0006887; GO:0030900; GO:0021766; GO:0016570; GO:0006886; GO:0021819; GO:0000226; GO:0007005; GO:0008045; GO:0030517; GO:0045786; GO:0045892; GO:1901215; GO:0046826; GO:0031397; GO:0045861; GO:0031914; GO:0007399; GO:0051402; GO:0030182; GO:0001764; GO:0031175; GO:0048812; GO:0006913; GO:0048709; GO:0018105; GO:0018107; GO:0016310; GO:2000251; GO:0045956; GO:0034352; GO:0043525; GO:1901216; GO:0099533; GO:0032092; GO:0045860; GO:0001934; GO:0090314; GO:1901387; GO:0046777; GO:0035418; GO:0006468; GO:0032801; GO:0043113; GO:0045055; GO:0042981; GO:0051726; GO:0030334; GO:0061001; GO:0016241; GO:0060078; GO:0099509; GO:1903076; GO:1905806; GO:0048167; GO:0051966; GO:1903421; GO:0000083; GO:0042220; GO:0009611; GO:0048511; GO:0014044; GO:0019233; GO:0042501; GO:0007519; GO:0007416; GO:0001963; GO:0035249; GO:0048488; GO:0016079; GO:0048489; GO:0021537; GO:0008542","PTHR24056:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1774|UniProtKB=Q00535","P06587; P00059; P05912; P00007"]
["CDK6",null,"CDK6","36","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1305",".BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DEV., .GLI., .IMUF., .IMUR., .MEL., .NOTCH., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .RTK., .SCLC., .ST., .TCR., .TRASR., .VIR.",null,"CYCLIN-DEPENDENT KINASE 6","astrocyte development; cell cycle; cell dedifferentiation; cell differentiation; cell division; dentate gyrus development; G1/S transition of mitotic cell cycle; generation of neurons; gliogenesis; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; hemopoiesis; lateral ventricle development; negative regulation of cell cycle; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of cellular senescence; negative regulation of epithelial cell proliferation; negative regulation of monocyte differentiation; negative regulation of myeloid cell differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; phosphorylation; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of gene expression; protein phosphorylation; regulation of cell cycle; regulation of cell motility; regulation of cell population proliferation; regulation of erythrocyte differentiation; regulation of gene expression; regulation of hematopoietic stem cell differentiation; response to virus; T cell differentiation in thymus; type B pancreatic cell development","ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; FBXO family protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cell projection; centrosome; cyclin D2-CDK6 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; mediator complex; microtubule organizing center; nucleoplasm; nucleus; ruffle","Cell cycle control","cyclin dependent kinase 6","http://www.ncbi.nlm.nih.gov/gene/?term=1021","1021","319887",null,null,null,null,"Q00534","F6UW72","A0A8I6A5X3","A0A8I3RZY6",null,"A0A5F8ATC9","GO:0042995; GO:0005813; GO:0097132; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0016592; GO:0005815; GO:0005654; GO:0005634; GO:0001726","GO:0005524; GO:0030332; GO:0004693; GO:0098770; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0014002; GO:0007049; GO:0043697; GO:0030154; GO:0051301; GO:0021542; GO:0000082; GO:0048699; GO:0042063; GO:0002244; GO:0060218; GO:0030097; GO:0021670; GO:0045786; GO:0045596; GO:0008285; GO:2000773; GO:0050680; GO:0045656; GO:0045638; GO:0045668; GO:0000122; GO:0007219; GO:0016310; GO:0001954; GO:0048146; GO:0010628; GO:0006468; GO:0051726; GO:2000145; GO:0042127; GO:0045646; GO:0010468; GO:1902036; GO:0009615; GO:0033077; GO:0003323","PTHR24056:SF130","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1777|UniProtKB=Q00534"]
["CDK6 - phospho","Tyr13","CDK6","36","rb",null,2,7,7,7,7,7,"# 1341",".BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DEV., .GLI., .IMUF., .IMUR., .MEL., .NOTCH., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .RTK., .SCLC., .ST., .TCR., .TRASR., .VIR.",null,"CYCLIN-DEPENDENT KINASE 6","astrocyte development; cell cycle; cell dedifferentiation; cell differentiation; cell division; dentate gyrus development; G1/S transition of mitotic cell cycle; generation of neurons; gliogenesis; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; hemopoiesis; lateral ventricle development; negative regulation of cell cycle; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of cellular senescence; negative regulation of epithelial cell proliferation; negative regulation of monocyte differentiation; negative regulation of myeloid cell differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; phosphorylation; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of gene expression; protein phosphorylation; regulation of cell cycle; regulation of cell motility; regulation of cell population proliferation; regulation of erythrocyte differentiation; regulation of gene expression; regulation of hematopoietic stem cell differentiation; response to virus; T cell differentiation in thymus; type B pancreatic cell development","ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; FBXO family protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cell projection; centrosome; cyclin D2-CDK6 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; mediator complex; microtubule organizing center; nucleoplasm; nucleus; ruffle","Cell cycle control","cyclin dependent kinase 6","http://www.ncbi.nlm.nih.gov/gene/?term=1021","1021","319887",null,null,null,null,"Q00534","F6UW72","A0A8I6A5X3","A0A8I3RZY6",null,"A0A5F8ATC9","GO:0042995; GO:0005813; GO:0097132; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0016592; GO:0005815; GO:0005654; GO:0005634; GO:0001726","GO:0005524; GO:0030332; GO:0004693; GO:0098770; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0014002; GO:0007049; GO:0043697; GO:0030154; GO:0051301; GO:0021542; GO:0000082; GO:0048699; GO:0042063; GO:0002244; GO:0060218; GO:0030097; GO:0021670; GO:0045786; GO:0045596; GO:0008285; GO:2000773; GO:0050680; GO:0045656; GO:0045638; GO:0045668; GO:0000122; GO:0007219; GO:0016310; GO:0001954; GO:0048146; GO:0010628; GO:0006468; GO:0051726; GO:2000145; GO:0042127; GO:0045646; GO:0010468; GO:1902036; GO:0009615; GO:0033077; GO:0003323","PTHR24056:SF130","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1777|UniProtKB=Q00534"]
["CDK6 - phospho","Tyr24","CDK6","36","rb",null,2,7,8,8,8,8,"# 1340",".BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DEV., .GLI., .IMUF., .IMUR., .MEL., .NOTCH., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .RTK., .SCLC., .ST., .TCR., .TRASR., .VIR.",null,"CYCLIN-DEPENDENT KINASE 6","astrocyte development; cell cycle; cell dedifferentiation; cell differentiation; cell division; dentate gyrus development; G1/S transition of mitotic cell cycle; generation of neurons; gliogenesis; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; hemopoiesis; lateral ventricle development; negative regulation of cell cycle; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of cellular senescence; negative regulation of epithelial cell proliferation; negative regulation of monocyte differentiation; negative regulation of myeloid cell differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; phosphorylation; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of gene expression; protein phosphorylation; regulation of cell cycle; regulation of cell motility; regulation of cell population proliferation; regulation of erythrocyte differentiation; regulation of gene expression; regulation of hematopoietic stem cell differentiation; response to virus; T cell differentiation in thymus; type B pancreatic cell development","ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; FBXO family protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cell projection; centrosome; cyclin D2-CDK6 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; mediator complex; microtubule organizing center; nucleoplasm; nucleus; ruffle","Cell cycle control","cyclin dependent kinase 6","http://www.ncbi.nlm.nih.gov/gene/?term=1021","1021","319887",null,null,null,null,"Q00534","F6UW72","A0A8I6A5X3","A0A8I3RZY6",null,"A0A5F8ATC9","GO:0042995; GO:0005813; GO:0097132; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0016592; GO:0005815; GO:0005654; GO:0005634; GO:0001726","GO:0005524; GO:0030332; GO:0004693; GO:0098770; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0014002; GO:0007049; GO:0043697; GO:0030154; GO:0051301; GO:0021542; GO:0000082; GO:0048699; GO:0042063; GO:0002244; GO:0060218; GO:0030097; GO:0021670; GO:0045786; GO:0045596; GO:0008285; GO:2000773; GO:0050680; GO:0045656; GO:0045638; GO:0045668; GO:0000122; GO:0007219; GO:0016310; GO:0001954; GO:0048146; GO:0010628; GO:0006468; GO:0051726; GO:2000145; GO:0042127; GO:0045646; GO:0010468; GO:1902036; GO:0009615; GO:0033077; GO:0003323","PTHR24056:SF130","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1777|UniProtKB=Q00534"]
["CDX2",null,"CDX2","38","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2210",".CCP., .CP., .OP., .OT., .TRASR.",null,"HOMEOBOX PROTEIN CDX-2","animal organ morphogenesis; anterior/posterior axis specification; anterior/posterior pattern specification; blastocyst development; blood vessel development; cell differentiation; endosome to lysosome transport; establishment or maintenance of epithelial cell apical/basal polarity; intestinal epithelial cell differentiation; labyrinthine layer development; negative regulation of transcription by RNA polymerase II; pattern specification process; placenta development; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of somitogenesis; regulation of transcription by RNA polymerase II; somatic stem cell population maintenance; stem cell differentiation; trophectodermal cell differentiation","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; methyl-CpG binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; condensed nuclear chromosome; nucleoplasm; nucleus; protein-containing complex; transcription repressor complex",null,"caudal type homeobox 2","http://www.ncbi.nlm.nih.gov/gene/?term=1045","1045","12591","66019","486028",null,null,"Q99626","P43241","Q9ESV7","A0A8I3PU71","F1RSU9",null,"GO:0000785; GO:0000794; GO:0005654; GO:0005634; GO:0032991; GO:0017053","GO:0003677; GO:0003700; GO:0000981; GO:0001227; GO:0003690; GO:0008327; GO:0005515; GO:0000978; GO:0000977; GO:0043565; GO:1990837","GO:0009887; GO:0009948; GO:0009952; GO:0001824; GO:0001568; GO:0030154; GO:0008333; GO:0045197; GO:0060575; GO:0060711; GO:0000122; GO:0007389; GO:0001890; GO:0045597; GO:0008284; GO:0045893; GO:0045944; GO:0006355; GO:0014807; GO:0006357; GO:0035019; GO:0048863; GO:0001829","PTHR24332:SF27","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1806|UniProtKB=Q99626"]
["CENP-A - phospho","Ser7","CENPA","17","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1034",".CCP., .CCY., .CP., .OP.",null,"HISTONE H3-LIKE CENTROMERIC PROTEIN A","cell cycle; cell division; CENP-A containing chromatin assembly; establishment of mitotic spindle orientation; kinetochore assembly; mitotic cytokinesis; protein localization to CENP-A containing chromatin; protein localization to chromosome, centromeric region","chromatin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","CENP-A containing chromatin; CENP-A containing nucleosome; chromatin; chromosome; chromosome, centromeric region; condensed chromosome, centromeric region; cytosol; nucleoplasm; nucleosome; nucleus; pericentric heterochromatin","Chromatin regulation / epigenetics","centromere protein A","http://www.ncbi.nlm.nih.gov/gene/?term=1058","1058","12615",null,"475692",null,"697312","P49450","O35216","A0A8I5ZWQ2","A0A8I3Q063",null,"F7AJX7","GO:0061638; GO:0043505; GO:0000785; GO:0005694; GO:0000775; GO:0000779; GO:0005829; GO:0005654; GO:0000786; GO:0005634; GO:0005721","GO:0003682; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0007049; GO:0051301; GO:0034080; GO:0000132; GO:0051382; GO:0000281; GO:0061644; GO:0071459","PTHR11426:SF255","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1851|UniProtKB=P49450"]
["Cerberus",null,"CER1","38","gt",null,7,4,"n/a","n/a","n/a","n/a","# 0907",".BMP., .CCP., .CP., .CSP., .DEV., .MIG., .OP., .OPA., .OT., .ST., .TRASR., .WNT.","Wnt signaling pathway","CERBERUS","animal organ development; anterior/posterior axis specification; anterior/posterior pattern specification; bone mineralization; cell migration involved in gastrulation; cell population proliferation; cellular response to cadmium ion; determination of dorsal identity; determination of heart left/right asymmetry; gastrulation; growth plate cartilage chondrocyte proliferation; negative regulation of activin receptor signaling pathway; negative regulation of BMP signaling pathway; negative regulation of cell population proliferation; negative regulation of mesoderm development; negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; negative regulation of Wnt signaling pathway; nervous system development; pattern specification process; sequestering of BMP in extracellular matrix; signal transduction involved in regulation of gene expression; ureteric bud development","BMP binding; cytokine activity; morphogen activity; protein homodimerization activity","extracellular region; extracellular space",null,"cerberus 1, DAN family BMP antagonist","http://www.ncbi.nlm.nih.gov/gene/?term=9350","9350","12622","500485","611037",null,"713924","O95813","O55233","B0BN87","A0A8I3NHH0",null,"F7DJA6","GO:0005576; GO:0005615","GO:0036122; GO:0005125; GO:0016015; GO:0042803","GO:0048513; GO:0009948; GO:0009952; GO:0030282; GO:0042074; GO:0008283; GO:0071276; GO:0048263; GO:0061371; GO:0007369; GO:0003419; GO:0032926; GO:0030514; GO:0008285; GO:2000381; GO:1900176; GO:0030178; GO:0007399; GO:0007389; GO:0035582; GO:0023019; GO:0001657","PTHR15273:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1862|UniProtKB=O95813","P00057"]
["CFB",null,"CFB","85","rb",null,1,4,"n/a","n/a","n/a","n/a","# 1661",".IIR., .IMU., .IMUR., .OP.",null,"COMPLEMENT FACTOR B","complement activation; complement activation, alternative pathway; immune system process; innate immune response; proteolysis; response to bacterium","complement binding; hydrolase activity; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity","blood microparticle; classical-complement-pathway C3/C5 convertase complex; extracellular exosome; extracellular region; extracellular space; plasma membrane",null,"complement factor B","http://www.ncbi.nlm.nih.gov/gene/?term=629","629",null,null,null,null,null,"P00751","P04186",null,"A0A8I3NF11","A0A287AAZ9","F6YJW2","GO:0072562; GO:0005601; GO:0070062; GO:0005576; GO:0005615; GO:0005886","GO:0001848; GO:0016787; GO:0008233; GO:0005515; GO:0004252; GO:0008236","GO:0006956; GO:0006957; GO:0002376; GO:0045087; GO:0006508; GO:0009617","PTHR46393:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1037|UniProtKB=P00751"]
["CFD",null,"CFD","28","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1659",".IIR., .IMU., .IMUR., .OP.",null,"COMPLEMENT FACTOR D","complement activation; complement activation, alternative pathway; immune system process; innate immune response; proteolysis; response to bacterium","hydrolase activity; peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity","extracellular exosome; extracellular region; extracellular space; ficolin-1-rich granule lumen; platelet alpha granule lumen; secretory granule lumen",null,"complement factor D","http://www.ncbi.nlm.nih.gov/gene/?term=1675","1675","11537",null,null,"396877",null,"P00746","P03953","G3V7H3",null,"P51779","F6YBP7","GO:0070062; GO:0005576; GO:0005615; GO:1904813; GO:0031093; GO:0034774","GO:0016787; GO:0008233; GO:0004252; GO:0008236","GO:0006956; GO:0006957; GO:0002376; GO:0045087; GO:0006508; GO:0009617","PTHR24271:SF54","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2771|UniProtKB=P00746"]
["c-Fos",null,"FOS","62","rb",null,1,4,"n/a","n/a","n/a","n/a","TK # 011",".ANG., .APO., .BCR., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .GPCR., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .PDGF., .RTK., .SREME., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Huntington disease; PDGF signaling pathway; Angiogenesis; Apoptosis signaling pathway","PROTO-ONCOGENE C-FOS","aging; cellular response to cadmium ion; cellular response to calcium ion; cellular response to epidermal growth factor stimulus; cellular response to extracellular stimulus; cellular response to hormone stimulus; cellular response to hypoxia; cellular response to parathyroid hormone stimulus; cellular response to phorbol 13-acetate 12-myristate; cellular response to prolactin; cellular response to reactive oxygen species; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cellular response to zinc ion starvation; conditioned taste aversion; DNA methylation; female pregnancy; inflammatory response; integrated stress response signaling; mononuclear cell differentiation; myoblast proliferation; nervous system development; osteoclast differentiation; positive regulation of DNA-templated transcription; positive regulation of miRNA transcription; positive regulation of neuron death; positive regulation of osteoclast differentiation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of gene expression; regulation of transcription by RNA polymerase II; response to activity; response to cAMP; response to cold; response to corticosterone; response to cytokine; response to ethanol; response to gravity; response to immobilization stress; response to insulin; response to light stimulus; response to lipopolysaccharide; response to mechanical stimulus; response to muscle stretch; response to organic cyclic compound; response to progesterone; response to steroid hormone; response to toxic substance; response to xenobiotic stimulus; skeletal muscle cell differentiation; skeletal muscle cell proliferation; sleep; SMAD protein signal transduction; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; identical protein binding; protein binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coregulator binding","chromatin; cytoplasm; cytosol; endoplasmic reticulum; membrane; neuron projection; nucleoplasm; nucleus; protein-DNA complex; RNA polymerase II transcription regulator complex; transcription factor AP-1 complex; transcription regulator complex","Transcription factor / protooncogene","Fos proto-oncogene, AP-1 transcription factor subunit","http://www.ncbi.nlm.nih.gov/gene/?term=2353","2353","14281","314322",null,"100144486",null,"P01100","P01101","P12841","A0A8I3NRT8","A0A140TAJ8","A0A1D5QZP4","GO:0000785; GO:0005737; GO:0005829; GO:0005783; GO:0016020; GO:0043005; GO:0005654; GO:0005634; GO:0032993; GO:0090575; GO:0035976; GO:0005667","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0003690; GO:0042802; GO:0005515; GO:0044877; GO:0000978; GO:0000979; GO:0061629; GO:0070412; GO:0043565; GO:1990837; GO:0000976; GO:0001221","GO:0007568; GO:0071276; GO:0071277; GO:0071364; GO:0031668; GO:0032870; GO:0071456; GO:0071374; GO:1904628; GO:1990646; GO:0034614; GO:0071560; GO:0071356; GO:0034224; GO:0001661; GO:0006306; GO:0007565; GO:0006954; GO:0140467; GO:1903131; GO:0051450; GO:0007399; GO:0030316; GO:0045893; GO:1902895; GO:1901216; GO:0045672; GO:0045944; GO:0006355; GO:0010468; GO:0006357; GO:0014823; GO:0051591; GO:0009409; GO:0051412; GO:0034097; GO:0045471; GO:0009629; GO:0035902; GO:0032868; GO:0009416; GO:0032496; GO:0009612; GO:0035994; GO:0014070; GO:0032570; GO:0048545; GO:0009636; GO:0009410; GO:0035914; GO:0014856; GO:0030431; GO:0060395; GO:0006366; GO:0007179","PTHR23351:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3796|UniProtKB=P01100","P06959; P00053; P00032; P00010; P00036; P06664; P00029; P00047; P00005; P00006"]
["Chk1 - phospho","Ser296","CHEK1","56","rb",null,2,1,8,8,1,8,"# 1612",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .OP., .OPA., .OT., .P53S., .ST., .TRASR.",null,"SERINE/THREONINE-PROTEIN KINASE CHK1","apoptotic process; apoptotic process involved in development; cell cycle; cellular response to caffeine; cellular response to DNA damage stimulus; cellular response to mechanical stimulus; cellular response to organic substance; DNA damage checkpoint signaling; DNA repair; DNA replication; G2/M transition of mitotic cell cycle; histone modification; inner cell mass cell proliferation; intracellular signal transduction; mitotic G2 DNA damage checkpoint signaling; mitotic G2/M transition checkpoint; negative regulation of DNA biosynthetic process; negative regulation of G0 to G1 transition; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of mitotic nuclear division; nucleus organization; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of cell cycle; protein phosphorylation; regulation of cell population proliferation; regulation of double-strand break repair via homologous recombination; regulation of gene expression; regulation of histone H3-K9 acetylation; regulation of mitotic centrosome separation; regulation of signal transduction by p53 class mediator; regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; replicative senescence; signal transduction in response to DNA damage; transcription initiation-coupled chromatin remodeling","ATP binding; histone H3T11 kinase activity; kinase activity; nucleotide binding; protein binding; protein domain specific binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","centrosome; chromatin; chromosome; chromosome, telomeric region; condensed nuclear chromosome; cytoplasm; cytoskeleton; cytosol; extracellular space; intracellular membrane-bounded organelle; microtubule organizing center; nucleoplasm; nucleus; protein-containing complex; replication fork","DNA damage","checkpoint kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=1111","1111","12649",null,null,null,null,"O14757","O35280",null,"A0A8P0SFN3","A0A5G2R0V2",null,"GO:0005813; GO:0000785; GO:0005694; GO:0000781; GO:0000794; GO:0005737; GO:0005856; GO:0005829; GO:0005615; GO:0043231; GO:0005815; GO:0005654; GO:0005634; GO:0032991; GO:0005657","GO:0005524; GO:0035402; GO:0016301; GO:0000166; GO:0005515; GO:0019904; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:1902742; GO:0007049; GO:0071313; GO:0006974; GO:0071260; GO:0071310; GO:0000077; GO:0006281; GO:0006260; GO:0000086; GO:0016570; GO:0001833; GO:0035556; GO:0007095; GO:0044818; GO:2000279; GO:0070317; GO:0010972; GO:0045839; GO:0006997; GO:0018107; GO:0016310; GO:0045787; GO:0006468; GO:0042127; GO:0010569; GO:0010468; GO:2000615; GO:0046602; GO:1901796; GO:0010767; GO:0090399; GO:0042770; GO:0045815","PTHR24343:SF424","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1925|UniProtKB=O14757"]
["Chk1 - phospho","Ser345","CHEK1","56","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1008",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .OP., .OPA., .OT., .P53S., .ST., .TRASR.",null,"SERINE/THREONINE-PROTEIN KINASE CHK1","apoptotic process; apoptotic process involved in development; cell cycle; cellular response to caffeine; cellular response to DNA damage stimulus; cellular response to mechanical stimulus; cellular response to organic substance; DNA damage checkpoint signaling; DNA repair; DNA replication; G2/M transition of mitotic cell cycle; histone modification; inner cell mass cell proliferation; intracellular signal transduction; mitotic G2 DNA damage checkpoint signaling; mitotic G2/M transition checkpoint; negative regulation of DNA biosynthetic process; negative regulation of G0 to G1 transition; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of mitotic nuclear division; nucleus organization; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of cell cycle; protein phosphorylation; regulation of cell population proliferation; regulation of double-strand break repair via homologous recombination; regulation of gene expression; regulation of histone H3-K9 acetylation; regulation of mitotic centrosome separation; regulation of signal transduction by p53 class mediator; regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; replicative senescence; signal transduction in response to DNA damage; transcription initiation-coupled chromatin remodeling","ATP binding; histone H3T11 kinase activity; kinase activity; nucleotide binding; protein binding; protein domain specific binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","centrosome; chromatin; chromosome; chromosome, telomeric region; condensed nuclear chromosome; cytoplasm; cytoskeleton; cytosol; extracellular space; intracellular membrane-bounded organelle; microtubule organizing center; nucleoplasm; nucleus; protein-containing complex; replication fork","DNA damage","checkpoint kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=1111","1111","12649",null,null,null,null,"O14757","O35280",null,"A0A8P0SFN3","A0A5G2R0V2",null,"GO:0005813; GO:0000785; GO:0005694; GO:0000781; GO:0000794; GO:0005737; GO:0005856; GO:0005829; GO:0005615; GO:0043231; GO:0005815; GO:0005654; GO:0005634; GO:0032991; GO:0005657","GO:0005524; GO:0035402; GO:0016301; GO:0000166; GO:0005515; GO:0019904; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:1902742; GO:0007049; GO:0071313; GO:0006974; GO:0071260; GO:0071310; GO:0000077; GO:0006281; GO:0006260; GO:0000086; GO:0016570; GO:0001833; GO:0035556; GO:0007095; GO:0044818; GO:2000279; GO:0070317; GO:0010972; GO:0045839; GO:0006997; GO:0018107; GO:0016310; GO:0045787; GO:0006468; GO:0042127; GO:0010569; GO:0010468; GO:2000615; GO:0046602; GO:1901796; GO:0010767; GO:0090399; GO:0042770; GO:0045815","PTHR24343:SF424","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1925|UniProtKB=O14757"]
["Chk2",null,"CHEK2","62","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1536",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .DRR., .OP., .OPA., .OT., .P53S., .ST., .TRASR.","p53 pathway","SERINE/THREONINE-PROTEIN KINASE CHK2","apoptotic process; cell cycle; cell division; cellular response to bisphenol A; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to xenobiotic stimulus; DNA damage checkpoint signaling; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; double-strand break repair; G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mitotic DNA damage checkpoint signaling; mitotic intra-S DNA damage checkpoint signaling; mitotic spindle assembly; negative regulation of DNA damage checkpoint; peptidyl-serine phosphorylation; phosphorylation; positive regulation of anoikis; positive regulation of DNA-templated transcription; positive regulation of protein phosphorylation; protein autophosphorylation; protein catabolic process; protein phosphorylation; protein stabilization; regulation of DNA-templated transcription; regulation of protein catabolic process; regulation of signal transduction by p53 class mediator; replicative senescence; response to gamma radiation; response to glycoside; signal transduction in response to DNA damage; thymocyte apoptotic process","ATP binding; identical protein binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase binding","chromosome, telomeric region; cytoplasm; Golgi apparatus; nucleoplasm; nucleus; PML body","Cell cycle control","checkpoint kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=11200","11200","50883",null,null,null,"713668","O96017","Q9Z265","F7F4E2",null,null,"F6VJA7","GO:0000781; GO:0005737; GO:0005794; GO:0005654; GO:0005634; GO:0016605","GO:0005524; GO:0042802; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740; GO:0031625","GO:0006915; GO:0007049; GO:0051301; GO:1903926; GO:0006974; GO:0071480; GO:0071466; GO:0000077; GO:0006977; GO:0006978; GO:0006281; GO:0006302; GO:0000086; GO:0008630; GO:0042771; GO:0044773; GO:0031573; GO:0090307; GO:2000002; GO:0018105; GO:0016310; GO:2000210; GO:0045893; GO:0001934; GO:0046777; GO:0030163; GO:0006468; GO:0050821; GO:0006355; GO:0042176; GO:1901796; GO:0090399; GO:0010332; GO:1903416; GO:0042770; GO:0070242","PTHR44167:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16627|UniProtKB=O96017","P00059"]
["Chk2",null,"CHEK2","62","ms",null,1,6,"n/a","n/a","n/a","n/a","# 2187",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .DRR., .OP., .OPA., .OT., .P53S., .ST., .TRASR.","p53 pathway","SERINE/THREONINE-PROTEIN KINASE CHK2","apoptotic process; cell cycle; cell division; cellular response to bisphenol A; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to xenobiotic stimulus; DNA damage checkpoint signaling; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; double-strand break repair; G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mitotic DNA damage checkpoint signaling; mitotic intra-S DNA damage checkpoint signaling; mitotic spindle assembly; negative regulation of DNA damage checkpoint; peptidyl-serine phosphorylation; phosphorylation; positive regulation of anoikis; positive regulation of DNA-templated transcription; positive regulation of protein phosphorylation; protein autophosphorylation; protein catabolic process; protein phosphorylation; protein stabilization; regulation of DNA-templated transcription; regulation of protein catabolic process; regulation of signal transduction by p53 class mediator; replicative senescence; response to gamma radiation; response to glycoside; signal transduction in response to DNA damage; thymocyte apoptotic process","ATP binding; identical protein binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase binding","chromosome, telomeric region; cytoplasm; Golgi apparatus; nucleoplasm; nucleus; PML body","Cell cycle control","checkpoint kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=11200","11200","50883",null,null,null,"713668","O96017","Q9Z265","F7F4E2",null,null,"F6VJA7","GO:0000781; GO:0005737; GO:0005794; GO:0005654; GO:0005634; GO:0016605","GO:0005524; GO:0042802; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740; GO:0031625","GO:0006915; GO:0007049; GO:0051301; GO:1903926; GO:0006974; GO:0071480; GO:0071466; GO:0000077; GO:0006977; GO:0006978; GO:0006281; GO:0006302; GO:0000086; GO:0008630; GO:0042771; GO:0044773; GO:0031573; GO:0090307; GO:2000002; GO:0018105; GO:0016310; GO:2000210; GO:0045893; GO:0001934; GO:0046777; GO:0030163; GO:0006468; GO:0050821; GO:0006355; GO:0042176; GO:1901796; GO:0090399; GO:0010332; GO:1903416; GO:0042770; GO:0070242","PTHR44167:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16627|UniProtKB=O96017","P00059"]
["Chk2 - phospho","Thr68","CHEK2","62","rb",null,2,7,7,8,4,4,"# 1012",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .DRR., .OP., .OPA., .OT., .P53S., .ST., .TRASR.","p53 pathway","SERINE/THREONINE-PROTEIN KINASE CHK2","apoptotic process; cell cycle; cell division; cellular response to bisphenol A; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to xenobiotic stimulus; DNA damage checkpoint signaling; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; double-strand break repair; G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mitotic DNA damage checkpoint signaling; mitotic intra-S DNA damage checkpoint signaling; mitotic spindle assembly; negative regulation of DNA damage checkpoint; peptidyl-serine phosphorylation; phosphorylation; positive regulation of anoikis; positive regulation of DNA-templated transcription; positive regulation of protein phosphorylation; protein autophosphorylation; protein catabolic process; protein phosphorylation; protein stabilization; regulation of DNA-templated transcription; regulation of protein catabolic process; regulation of signal transduction by p53 class mediator; replicative senescence; response to gamma radiation; response to glycoside; signal transduction in response to DNA damage; thymocyte apoptotic process","ATP binding; identical protein binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase binding","chromosome, telomeric region; cytoplasm; Golgi apparatus; nucleoplasm; nucleus; PML body","Cell cycle control","checkpoint kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=11200","11200","50883",null,null,null,"713668","O96017","Q9Z265","F7F4E2",null,null,"F6VJA7","GO:0000781; GO:0005737; GO:0005794; GO:0005654; GO:0005634; GO:0016605","GO:0005524; GO:0042802; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740; GO:0031625","GO:0006915; GO:0007049; GO:0051301; GO:1903926; GO:0006974; GO:0071480; GO:0071466; GO:0000077; GO:0006977; GO:0006978; GO:0006281; GO:0006302; GO:0000086; GO:0008630; GO:0042771; GO:0044773; GO:0031573; GO:0090307; GO:2000002; GO:0018105; GO:0016310; GO:2000210; GO:0045893; GO:0001934; GO:0046777; GO:0030163; GO:0006468; GO:0050821; GO:0006355; GO:0042176; GO:1901796; GO:0090399; GO:0010332; GO:1903416; GO:0042770; GO:0070242","PTHR44167:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16627|UniProtKB=O96017","P00059"]
["CHOP",null,"DDIT3","27","ms",null,2,2,8,8,8,8,"# 0424",".ALZ., .APH., .APO., .CCP., .CCY., .CD., .CSP., .DDR., .DEV., .DI., .MAPK., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .ST., .TRASR., .WNT.","Oxidative stress response","DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN","anterior/posterior axis specification; apoptotic process; artery development; ATF6-mediated unfolded protein response; blood vessel maturation; cell cycle; cell redox homeostasis; cellular response to DNA damage stimulus; endoplasmic reticulum unfolded protein response; ER overload response; establishment of protein localization to mitochondrion; gene expression; integrated stress response signaling; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to nitrosative stress; negative regulation of canonical Wnt signaling pathway; negative regulation of cold-induced thermogenesis; negative regulation of CREB transcription factor activity; negative regulation of determination of dorsal identity; negative regulation of DNA binding; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of fat cell differentiation; negative regulation of interleukin-17 production; negative regulation of interleukin-4 production; negative regulation of myoblast differentiation; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein kinase B signaling; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; negative regulation of transcription by RNA polymerase II; negative regulation of type II interferon production; PERK-mediated unfolded protein response; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of interleukin-8 production; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of neuron apoptotic process; positive regulation of neuron death; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of autophagy; regulation of cell cycle; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to stress; release of sequestered calcium ion into cytosol; response to endoplasmic reticulum stress; response to platelet-derived growth factor; response to starvation; response to unfolded protein; response to wounding; sensory perception of sound; vascular associated smooth muscle cell migration; vascular associated smooth muscle cell proliferation; Wnt signaling pathway","cAMP response element binding protein binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; leucine zipper domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription cis-regulatory region binding; transcription regulator inhibitor activity","CHOP-ATF3 complex; CHOP-ATF4 complex; CHOP-C/EBP complex; chromatin; cytoplasm; cytosol; late endosome; nucleus; protein-DNA complex; RNA polymerase II transcription regulator complex; transcription regulator complex","Translational control","DNA damage inducible transcript 3","http://www.ncbi.nlm.nih.gov/gene/?term=1649","1649","13198",null,"607439",null,null,"P35638","P35639","A0A0G2K1H3","A0A8I3NHJ0",null,"A0A5K1UZV9","GO:1990622; GO:1990617; GO:0036488; GO:0000785; GO:0005737; GO:0005829; GO:0005770; GO:0005634; GO:0032993; GO:0090575; GO:0005667","GO:0008140; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0042802; GO:0043522; GO:0005515; GO:0046982; GO:0042803; GO:0000978; GO:0061629; GO:0000976; GO:0140416","GO:0009948; GO:0006915; GO:0060840; GO:0036500; GO:0001955; GO:0007049; GO:0045454; GO:0006974; GO:0030968; GO:0006983; GO:0072655; GO:0010467; GO:0140467; GO:0070059; GO:1990442; GO:0090090; GO:0120163; GO:0032792; GO:2000016; GO:0043392; GO:0043433; GO:0045892; GO:0045599; GO:0032700; GO:0032713; GO:0045662; GO:0032088; GO:0051898; GO:1903026; GO:0000122; GO:0032689; GO:0036499; GO:0051091; GO:0045893; GO:1902237; GO:0032757; GO:2001244; GO:0043525; GO:1901216; GO:0045944; GO:1990440; GO:0043161; GO:0010506; GO:0051726; GO:0006355; GO:0006357; GO:0043618; GO:0051209; GO:0034976; GO:0036119; GO:0042594; GO:0006986; GO:0009611; GO:0007605; GO:1904738; GO:1990874; GO:0016055","PTHR16833:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2726|UniProtKB=P35638","P00046"]
["CIP2A",null,"CIP2A","102","rb",null,2,2,2,2,2,2,"# 1426",null,null,"PROTEIN CIP2A",null,"cadherin binding; protein binding; protein homodimerization activity","cytoplasm; cytosol; membrane; plasma membrane","Cell growth / tumor formation","cellular inhibitor of PP2A","http://www.ncbi.nlm.nih.gov/gene/?term=57650","57650","224171",null,"478554",null,null,"Q8TCG1","Q8BWY9","A0A8I5ZXN3","A0A8P0NP78",null,"F6T1A3","GO:0005737; GO:0005829; GO:0016020; GO:0005886","GO:0045296; GO:0005515; GO:0042803",null,"PTHR23161:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=29302|UniProtKB=Q8TCG1"]
["CITED2",null,"CITED2","28","rb",null,1,1,8,8,8,8,"# 0934",".APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HIF., .MIG., .OP., .OPA., .OT., .SREME., .ST., .TD., .TGFB., .TMAT., .TRASR.","TGF-beta signaling pathway","CBP/P300-INTERACTING TRANSACTIVATOR 2","adrenal cortex formation; adrenal gland development; blood vessel development; bone morphogenesis; cardiac neural crest cell development involved in heart development; cardiac septum morphogenesis; cell differentiation; cell population proliferation; cellular response to growth factor stimulus; cellular senescence; central nervous system development; cranial nerve morphogenesis; decidualization; determination of heart left/right asymmetry; determination of left/right symmetry; embryonic camera-type eye morphogenesis; embryonic heart tube left/right pattern formation; embryonic placenta development; embryonic process involved in female pregnancy; endocardial cushion development; erythrocyte development; granulocyte differentiation; heart development; heart looping; hematopoietic progenitor cell differentiation; in utero embryonic development; left/right axis specification; left/right pattern formation; lens morphogenesis in camera-type eye; leukocyte differentiation; liver development; male gonad development; negative regulation of apoptotic process; negative regulation of cardiac muscle cell proliferation; negative regulation of cell migration; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; neural tube closure; neural tube formation; nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; outflow tract morphogenesis; peripheral nervous system development; positive regulation of cell cycle; positive regulation of cell-cell adhesion; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of male gonad development; positive regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; pulmonary artery morphogenesis; regulation of animal organ formation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to estrogen; response to fluid shear stress; response to hypoxia; response to mechanical stimulus; sex determination; skeletal muscle cell differentiation; spleen development; thymus development; transforming growth factor beta receptor signaling pathway; trophectodermal cell differentiation; vasculature development; vasculogenesis; ventricular septum development; ventricular septum morphogenesis","chromatin binding; histone acetyltransferase binding; LBD domain binding; molecular function activator activity; protein binding; protein domain specific binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription coactivator activity; transcription corepressor activity","chromatin; nucleoplasm; nucleus; protein-containing complex",null,"Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2","http://www.ncbi.nlm.nih.gov/gene/?term=10370","10370","17684","114490","484010","100156022",null,"Q99967","O35740","Q99MA1","A0A8I3NI02","A0A287A4Z1","A0A1D5QPF9","GO:0000785; GO:0005654; GO:0005634; GO:0032991","GO:0003682; GO:0035035; GO:0050693; GO:0140677; GO:0005515; GO:0019904; GO:0061629; GO:0046332; GO:0003713; GO:0003714","GO:0035802; GO:0030325; GO:0001568; GO:0060349; GO:0061308; GO:0060411; GO:0030154; GO:0008283; GO:0071363; GO:0090398; GO:0007417; GO:0021602; GO:0046697; GO:0061371; GO:0007368; GO:0048596; GO:0060971; GO:0001892; GO:0060136; GO:0003197; GO:0048821; GO:0030851; GO:0007507; GO:0001947; GO:0002244; GO:0001701; GO:0070986; GO:0060972; GO:0002089; GO:0002521; GO:0001889; GO:0008584; GO:0043066; GO:0060044; GO:0030336; GO:0045892; GO:0010629; GO:0000122; GO:0061428; GO:0001843; GO:0001841; GO:1900164; GO:0003151; GO:0007422; GO:0045787; GO:0022409; GO:0045893; GO:0010628; GO:2000020; GO:0035360; GO:0045944; GO:0030511; GO:0061156; GO:0003156; GO:0006355; GO:0006357; GO:0043627; GO:0034405; GO:0001666; GO:0009612; GO:0007530; GO:0035914; GO:0048536; GO:0048538; GO:0007179; GO:0001829; GO:0001944; GO:0001570; GO:0003281; GO:0060412","PTHR17045:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1987|UniProtKB=Q99967","P00052"]
["c-Jun",null,"JUN","48, 43","rb",null,1,1,8,8,8,8,"# 3085",".ANG., .APH., .APO., .BCR., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .FAS., .GPCR., .HEPB., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VIR., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; Ras Pathway; Huntington disease; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Oxidative stress response; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR AP-1","angiogenesis; apoptotic process; axon regeneration; cell population proliferation; cellular response to anisomycin; cellular response to cadmium ion; cellular response to calcium ion; cellular response to reactive oxygen species; eyelid development in camera-type eye; integrated stress response signaling; leading edge cell differentiation; liver development; microglial cell activation; monocyte differentiation; negative regulation by host of viral transcription; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of DNA binding; negative regulation of DNA-templated transcription; negative regulation of neuron apoptotic process; negative regulation of protein autophosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; outflow tract morphogenesis; positive regulation by host of viral transcription; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of DNA-templated transcription initiation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of vascular associated smooth muscle cell proliferation; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to muscle stretch; response to xenobiotic stimulus; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway","cAMP response element binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; general transcription initiation factor binding; GTPase activator activity; identical protein binding; protein binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding","chromatin; euchromatin; nuclear chromosome; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex; transcription factor AP-1 complex; transcription regulator complex; transcription repressor complex","Transcription factor / protooncogene","Jun proto-oncogene, AP-1 transcription factor subunit","http://www.ncbi.nlm.nih.gov/gene/?term=3725","3725","16476","24516",null,null,null,"P05412","P05627","P17325","A0A8I3RTD9",null,null,"GO:0000785; GO:0000791; GO:0000228; GO:0005654; GO:0005634; GO:0005886; GO:0090575; GO:0035976; GO:0005667; GO:0017053","GO:0035497; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0003690; GO:0019899; GO:0140296; GO:0005096; GO:0042802; GO:0005515; GO:0003723; GO:0000978; GO:0061629; GO:0070412; GO:1990837; GO:0000976; GO:0031625; GO:0044389","GO:0001525; GO:0006915; GO:0031103; GO:0008283; GO:0072740; GO:0071276; GO:0071277; GO:0034614; GO:0061029; GO:0140467; GO:0035026; GO:0001889; GO:0001774; GO:0030224; GO:0043922; GO:0043066; GO:0008285; GO:0043392; GO:0045892; GO:0043524; GO:0031953; GO:0000122; GO:1990441; GO:0003151; GO:0043923; GO:0043065; GO:0045893; GO:2000144; GO:0001938; GO:0010634; GO:0070374; GO:0048146; GO:1902895; GO:0045944; GO:1901522; GO:1904707; GO:0051726; GO:0042127; GO:0006355; GO:0006357; GO:0035994; GO:0009410; GO:0060395; GO:0007179","PTHR11462:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6204|UniProtKB=P05412","P06959; P00053; P00052; P00010; P06664; P04393; P00029; P00047; P00005; P00054; P00046; P00020; P00031; P00006"]
["c-Jun - phospho","Ser63","JUN","48","rb",null,1.1000000000000001,4,4,4,4,4,"# 1948",".ANG., .APH., .APO., .BCR., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .FAS., .GPCR., .HEPB., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VIR., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; Ras Pathway; Huntington disease; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Oxidative stress response; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR AP-1","angiogenesis; apoptotic process; axon regeneration; cell population proliferation; cellular response to anisomycin; cellular response to cadmium ion; cellular response to calcium ion; cellular response to reactive oxygen species; eyelid development in camera-type eye; integrated stress response signaling; leading edge cell differentiation; liver development; microglial cell activation; monocyte differentiation; negative regulation by host of viral transcription; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of DNA binding; negative regulation of DNA-templated transcription; negative regulation of neuron apoptotic process; negative regulation of protein autophosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; outflow tract morphogenesis; positive regulation by host of viral transcription; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of DNA-templated transcription initiation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of vascular associated smooth muscle cell proliferation; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to muscle stretch; response to xenobiotic stimulus; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway","cAMP response element binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; general transcription initiation factor binding; GTPase activator activity; identical protein binding; protein binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding","chromatin; euchromatin; nuclear chromosome; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex; transcription factor AP-1 complex; transcription regulator complex; transcription repressor complex","Transcription factor / protooncogene","Jun proto-oncogene, AP-1 transcription factor subunit","http://www.ncbi.nlm.nih.gov/gene/?term=3725","3725","16476","24516",null,null,null,"P05412","P05627","P17325","A0A8I3RTD9",null,null,"GO:0000785; GO:0000791; GO:0000228; GO:0005654; GO:0005634; GO:0005886; GO:0090575; GO:0035976; GO:0005667; GO:0017053","GO:0035497; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0003690; GO:0019899; GO:0140296; GO:0005096; GO:0042802; GO:0005515; GO:0003723; GO:0000978; GO:0061629; GO:0070412; GO:1990837; GO:0000976; GO:0031625; GO:0044389","GO:0001525; GO:0006915; GO:0031103; GO:0008283; GO:0072740; GO:0071276; GO:0071277; GO:0034614; GO:0061029; GO:0140467; GO:0035026; GO:0001889; GO:0001774; GO:0030224; GO:0043922; GO:0043066; GO:0008285; GO:0043392; GO:0045892; GO:0043524; GO:0031953; GO:0000122; GO:1990441; GO:0003151; GO:0043923; GO:0043065; GO:0045893; GO:2000144; GO:0001938; GO:0010634; GO:0070374; GO:0048146; GO:1902895; GO:0045944; GO:1901522; GO:1904707; GO:0051726; GO:0042127; GO:0006355; GO:0006357; GO:0035994; GO:0009410; GO:0060395; GO:0007179","PTHR11462:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6204|UniProtKB=P05412","P06959; P00053; P00052; P00010; P06664; P04393; P00029; P00047; P00005; P00054; P00046; P00020; P00031; P00006"]
["c-Jun - phospho","Ser73","JUN","48","rb",null,1,4,4,4,4,4,"# 1897",".ANG., .APH., .APO., .BCR., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .FAS., .GPCR., .HEPB., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VIR., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; Ras Pathway; Huntington disease; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Oxidative stress response; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR AP-1","angiogenesis; apoptotic process; axon regeneration; cell population proliferation; cellular response to anisomycin; cellular response to cadmium ion; cellular response to calcium ion; cellular response to reactive oxygen species; eyelid development in camera-type eye; integrated stress response signaling; leading edge cell differentiation; liver development; microglial cell activation; monocyte differentiation; negative regulation by host of viral transcription; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of DNA binding; negative regulation of DNA-templated transcription; negative regulation of neuron apoptotic process; negative regulation of protein autophosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; outflow tract morphogenesis; positive regulation by host of viral transcription; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of DNA-templated transcription initiation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of vascular associated smooth muscle cell proliferation; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to muscle stretch; response to xenobiotic stimulus; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway","cAMP response element binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; general transcription initiation factor binding; GTPase activator activity; identical protein binding; protein binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding","chromatin; euchromatin; nuclear chromosome; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex; transcription factor AP-1 complex; transcription regulator complex; transcription repressor complex","Transcription factor / protooncogene","Jun proto-oncogene, AP-1 transcription factor subunit","http://www.ncbi.nlm.nih.gov/gene/?term=3725","3725","16476","24516",null,null,null,"P05412","P05627","P17325","A0A8I3RTD9",null,null,"GO:0000785; GO:0000791; GO:0000228; GO:0005654; GO:0005634; GO:0005886; GO:0090575; GO:0035976; GO:0005667; GO:0017053","GO:0035497; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0003690; GO:0019899; GO:0140296; GO:0005096; GO:0042802; GO:0005515; GO:0003723; GO:0000978; GO:0061629; GO:0070412; GO:1990837; GO:0000976; GO:0031625; GO:0044389","GO:0001525; GO:0006915; GO:0031103; GO:0008283; GO:0072740; GO:0071276; GO:0071277; GO:0034614; GO:0061029; GO:0140467; GO:0035026; GO:0001889; GO:0001774; GO:0030224; GO:0043922; GO:0043066; GO:0008285; GO:0043392; GO:0045892; GO:0043524; GO:0031953; GO:0000122; GO:1990441; GO:0003151; GO:0043923; GO:0043065; GO:0045893; GO:2000144; GO:0001938; GO:0010634; GO:0070374; GO:0048146; GO:1902895; GO:0045944; GO:1901522; GO:1904707; GO:0051726; GO:0042127; GO:0006355; GO:0006357; GO:0035994; GO:0009410; GO:0060395; GO:0007179","PTHR11462:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6204|UniProtKB=P05412","P06959; P00053; P00052; P00010; P06664; P04393; P00029; P00047; P00005; P00054; P00046; P00020; P00031; P00006"]
["c-Jun - phospho","Ser73","JUN","48","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2803",".ANG., .APH., .APO., .BCR., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DEV., .DI., .DRR., .EGFR., .FAS., .GPCR., .HEPB., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VIR., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; Ras Pathway; Huntington disease; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Oxidative stress response; FAS signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR AP-1","angiogenesis; apoptotic process; axon regeneration; cell population proliferation; cellular response to anisomycin; cellular response to cadmium ion; cellular response to calcium ion; cellular response to reactive oxygen species; eyelid development in camera-type eye; integrated stress response signaling; leading edge cell differentiation; liver development; microglial cell activation; monocyte differentiation; negative regulation by host of viral transcription; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of DNA binding; negative regulation of DNA-templated transcription; negative regulation of neuron apoptotic process; negative regulation of protein autophosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; outflow tract morphogenesis; positive regulation by host of viral transcription; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of DNA-templated transcription initiation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of vascular associated smooth muscle cell proliferation; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to muscle stretch; response to xenobiotic stimulus; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway","cAMP response element binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; general transcription initiation factor binding; GTPase activator activity; identical protein binding; protein binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding","chromatin; euchromatin; nuclear chromosome; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex; transcription factor AP-1 complex; transcription regulator complex; transcription repressor complex","Transcription factor / protooncogene","Jun proto-oncogene, AP-1 transcription factor subunit","http://www.ncbi.nlm.nih.gov/gene/?term=3725","3725","16476","24516",null,null,null,"P05412","P05627","P17325","A0A8I3RTD9",null,null,"GO:0000785; GO:0000791; GO:0000228; GO:0005654; GO:0005634; GO:0005886; GO:0090575; GO:0035976; GO:0005667; GO:0017053","GO:0035497; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0003690; GO:0019899; GO:0140296; GO:0005096; GO:0042802; GO:0005515; GO:0003723; GO:0000978; GO:0061629; GO:0070412; GO:1990837; GO:0000976; GO:0031625; GO:0044389","GO:0001525; GO:0006915; GO:0031103; GO:0008283; GO:0072740; GO:0071276; GO:0071277; GO:0034614; GO:0061029; GO:0140467; GO:0035026; GO:0001889; GO:0001774; GO:0030224; GO:0043922; GO:0043066; GO:0008285; GO:0043392; GO:0045892; GO:0043524; GO:0031953; GO:0000122; GO:1990441; GO:0003151; GO:0043923; GO:0043065; GO:0045893; GO:2000144; GO:0001938; GO:0010634; GO:0070374; GO:0048146; GO:1902895; GO:0045944; GO:1901522; GO:1904707; GO:0051726; GO:0042127; GO:0006355; GO:0006357; GO:0035994; GO:0009410; GO:0060395; GO:0007179","PTHR11462:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6204|UniProtKB=P05412","P06959; P00053; P00052; P00010; P06664; P04393; P00029; P00047; P00005; P00054; P00046; P00020; P00031; P00006"]
["c-Kit",null,"KIT","110","rb",null,1,7,"n/a","n/a","n/a","n/a","# 1242",".AML., .BCR., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .CUR., .D300., .DEV., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .STAT., .TCR., .TRASR.",null,"MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT","actin cytoskeleton reorganization; B cell differentiation; cell chemotaxis; cell population proliferation; cellular response to stimulus; cellular response to thyroid hormone stimulus; cytokine-mediated signaling pathway; detection of mechanical stimulus involved in sensory perception of sound; developmental pigmentation; digestive tract development; ectopic germ cell programmed cell death; embryonic hemopoiesis; epithelial cell proliferation; erythrocyte differentiation; erythropoietin-mediated signaling pathway; Fc receptor signaling pathway; germ cell migration; glycosphingolipid metabolic process; hematopoietic progenitor cell differentiation; hematopoietic stem cell migration; hemopoiesis; immature B cell differentiation; inflammatory response; intracellular signal transduction; Kit signaling pathway; lamellipodium assembly; lymphoid progenitor cell differentiation; male gonad development; mast cell chemotaxis; mast cell degranulation; mast cell differentiation; mast cell proliferation; megakaryocyte development; melanocyte adhesion; melanocyte differentiation; melanocyte migration; myeloid progenitor cell differentiation; negative regulation of developmental process; negative regulation of programmed cell death; negative regulation of reproductive process; ovarian follicle development; peptidyl-tyrosine phosphorylation; phosphorylation; pigmentation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of colon smooth muscle contraction; positive regulation of dendritic cell cytokine production; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of long-term neuronal synaptic plasticity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of mast cell cytokine production; positive regulation of mast cell proliferation; positive regulation of Notch signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase C activity; positive regulation of protein modification process; positive regulation of pseudopodium assembly; positive regulation of pyloric antrum smooth muscle contraction; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of response to stimulus; positive regulation of small intestine smooth muscle contraction; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular associated smooth muscle cell differentiation; programmed cell death; protein autophosphorylation; protein phosphorylation; regulation of bile acid metabolic process; regulation of cell population proliferation; regulation of cell shape; regulation of MAPK cascade; response to cadmium ion; response to radiation; signal transduction; somatic stem cell division; somatic stem cell population maintenance; spermatid development; spermatogenesis; stem cell differentiation; stem cell population maintenance; T cell differentiation; tongue development; transmembrane receptor protein tyrosine kinase signaling pathway; visual learning","ATP binding; cytokine binding; kinase activity; metal ion binding; nucleotide binding; protease binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; SH2 domain binding; stem cell factor receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","acrosomal vesicle; cell surface; cell-cell junction; cytoplasm; cytoplasmic side of plasma membrane; external side of plasma membrane; extracellular space; fibrillar center; membrane; plasma membrane; receptor complex","Tyrosine kinase / adaptor","KIT proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3815","3815","16590","64030","403811",null,null,"P10721","P05532","A0A0G2JTL4","O97799","A0A5G2QNL8",null,"GO:0001669; GO:0009986; GO:0005911; GO:0005737; GO:0009898; GO:0009897; GO:0005615; GO:0001650; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0019955; GO:0016301; GO:0046872; GO:0000166; GO:0002020; GO:0005515; GO:0042803; GO:0004672; GO:0004713; GO:0042169; GO:0005020; GO:0016740; GO:0004714","GO:0031532; GO:0030183; GO:0060326; GO:0008283; GO:0051716; GO:0097067; GO:0019221; GO:0050910; GO:0048066; GO:0048565; GO:0035234; GO:0035162; GO:0050673; GO:0030218; GO:0038162; GO:0038093; GO:0008354; GO:0006687; GO:0002244; GO:0035701; GO:0030097; GO:0002327; GO:0006954; GO:0035556; GO:0038109; GO:0030032; GO:0002320; GO:0008584; GO:0002551; GO:0043303; GO:0060374; GO:0070662; GO:0035855; GO:0097326; GO:0030318; GO:0097324; GO:0002318; GO:0051093; GO:0043069; GO:2000242; GO:0001541; GO:0018108; GO:0016310; GO:0043473; GO:0030335; GO:0008284; GO:1904343; GO:0002732; GO:0051091; GO:0010628; GO:0033674; GO:0048170; GO:0043406; GO:0043410; GO:0032765; GO:0070668; GO:0045747; GO:0043552; GO:0014068; GO:0010863; GO:0031401; GO:0031274; GO:0120072; GO:0046427; GO:0048584; GO:1904349; GO:0042531; GO:1905065; GO:0012501; GO:0046777; GO:0006468; GO:1904251; GO:0042127; GO:0008360; GO:0043408; GO:0046686; GO:0009314; GO:0007165; GO:0048103; GO:0035019; GO:0007286; GO:0007283; GO:0048863; GO:0019827; GO:0030217; GO:0043586; GO:0007169; GO:0008542","PTHR24416:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6342|UniProtKB=P10721"]
["Claudin-1",null,"CLDN1","22","rb",null,1,2,2,8,2,2,"# 0737",".CCP., .CD., .CP., .CSP., .DRR., .IIR., .IMUR., .MIG., .OP., .OT., .TNF., .VIR.",null,"CLAUDIN-1","aging; bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell adhesion; cell junction maintenance; cell-cell junction organization; cellular response to butyrate; cellular response to lead ion; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cellular response to type II interferon; establishment of blood-nerve barrier; establishment of endothelial intestinal barrier; establishment of skin barrier; hyperosmotic salinity response; liver regeneration; maintenance of blood-brain barrier; positive regulation of bicellular tight junction assembly; positive regulation of cell migration; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of wound healing; protein complex oligomerization; response to dexamethasone; response to ethanol; response to interleukin-18; response to lipopolysaccharide; response to toxic substance; viral entry into host cell; xenobiotic transport across blood-nerve barrier","identical protein binding; protein binding; structural molecule activity; virus receptor activity","anchoring junction; apical plasma membrane; basolateral plasma membrane; bicellular tight junction; cell junction; cell-cell junction; cytoplasm; lateral plasma membrane; membrane; plasma membrane; protein-containing complex; tight junction","Cytoskeletal regulation / Adhesion","claudin 1","http://www.ncbi.nlm.nih.gov/gene/?term=9076","9076","12737","65129","608207",null,"704330","O95832","O88551","P56745","A0A8I3PHM6",null,"F6TZW7","GO:0070161; GO:0016324; GO:0016323; GO:0005923; GO:0030054; GO:0005911; GO:0005737; GO:0016328; GO:0016020; GO:0005886; GO:0032991; GO:0070160","GO:0042802; GO:0005515; GO:0005198; GO:0001618","GO:0007568; GO:0070830; GO:0016338; GO:0007155; GO:0034331; GO:0045216; GO:1903545; GO:0071284; GO:0071560; GO:0071356; GO:0071346; GO:0008065; GO:0090557; GO:0061436; GO:0042538; GO:0097421; GO:0035633; GO:1903348; GO:0030335; GO:0060054; GO:0090303; GO:0051259; GO:0071548; GO:0045471; GO:0070673; GO:0032496; GO:0009636; GO:0046718; GO:0061772","PTHR12002:SF92","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2032|UniProtKB=O95832"]
["c-Met (HGF/SF receptor)",null,"MET","145","ms",null,2,6,2,7,2.1,8,"# 0749",".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D300., .DRAS., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR RECEPTOR","branching morphogenesis of an epithelial tube; cell migration; cell surface receptor signaling pathway; endothelial cell morphogenesis; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; liver development; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron differentiation; pancreas development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of kinase activity; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; protein phosphorylation; semaphorin-plexin signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; hepatocyte growth factor receptor activity; identical protein binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; semaphorin receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; extracellular region; membrane; plasma membrane; receptor complex","Tyrosine kinase / adaptor / protooncogene","MET proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=4233","4233",null,null,null,"654328",null,"P08581","D3YVY2","A0A8I6GEH2","A0A8I3NIK6","Q2QLE0","A0A1D5QZ12","GO:0009925; GO:0009986; GO:0005576; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0005008; GO:0042802; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0017154; GO:0016740; GO:0004714","GO:0048754; GO:0016477; GO:0007166; GO:0001886; GO:0061436; GO:0048012; GO:0001889; GO:0010507; GO:1905098; GO:1901299; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0030182; GO:0031016; GO:0018108; GO:0006909; GO:0016310; GO:0050918; GO:2001028; GO:0033674; GO:0031116; GO:0051897; GO:0045944; GO:0006468; GO:0071526; GO:0007165; GO:0007169","PTHR24416:SF483","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7029|UniProtKB=P08581"]
["c-Met (HGF/SF receptor)",null,"MET","170, 145","ms",null,1,4,4,4,8,1.1000000000000001,"# 0434",".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR RECEPTOR","branching morphogenesis of an epithelial tube; cell migration; cell surface receptor signaling pathway; endothelial cell morphogenesis; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; liver development; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron differentiation; pancreas development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of kinase activity; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; protein phosphorylation; semaphorin-plexin signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; hepatocyte growth factor receptor activity; identical protein binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; semaphorin receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; extracellular region; membrane; plasma membrane; receptor complex","Tyrosine kinase / adaptor / protooncogene","MET proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=4233","4233",null,null,null,"654328",null,"P08581","D3YVY2","A0A8I6GEH2","A0A8I3NIK6","Q2QLE0","A0A1D5QZ12","GO:0009925; GO:0009986; GO:0005576; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0005008; GO:0042802; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0017154; GO:0016740; GO:0004714","GO:0048754; GO:0016477; GO:0007166; GO:0001886; GO:0061436; GO:0048012; GO:0001889; GO:0010507; GO:1905098; GO:1901299; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0030182; GO:0031016; GO:0018108; GO:0006909; GO:0016310; GO:0050918; GO:2001028; GO:0033674; GO:0031116; GO:0051897; GO:0045944; GO:0006468; GO:0071526; GO:0007165; GO:0007169","PTHR24416:SF483","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7029|UniProtKB=P08581"]
["c-Met (HGF/SF receptor)",null,"MET","170","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1931",".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR RECEPTOR","branching morphogenesis of an epithelial tube; cell migration; cell surface receptor signaling pathway; endothelial cell morphogenesis; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; liver development; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron differentiation; pancreas development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of kinase activity; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; protein phosphorylation; semaphorin-plexin signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; hepatocyte growth factor receptor activity; identical protein binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; semaphorin receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; extracellular region; membrane; plasma membrane; receptor complex","Tyrosine kinase / adaptor / protooncogene","MET proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=4233","4233",null,null,null,"654328",null,"P08581","D3YVY2","A0A8I6GEH2","A0A8I3NIK6","Q2QLE0","A0A1D5QZ12","GO:0009925; GO:0009986; GO:0005576; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0005008; GO:0042802; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0017154; GO:0016740; GO:0004714","GO:0048754; GO:0016477; GO:0007166; GO:0001886; GO:0061436; GO:0048012; GO:0001889; GO:0010507; GO:1905098; GO:1901299; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0030182; GO:0031016; GO:0018108; GO:0006909; GO:0016310; GO:0050918; GO:2001028; GO:0033674; GO:0031116; GO:0051897; GO:0045944; GO:0006468; GO:0071526; GO:0007165; GO:0007169","PTHR24416:SF483","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7029|UniProtKB=P08581"]
["c-Met (HGF/SF receptor) - phospho","Tyr1003","MET","145","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2478",".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR RECEPTOR","branching morphogenesis of an epithelial tube; cell migration; cell surface receptor signaling pathway; endothelial cell morphogenesis; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; liver development; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron differentiation; pancreas development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of kinase activity; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; protein phosphorylation; semaphorin-plexin signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; hepatocyte growth factor receptor activity; identical protein binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; semaphorin receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; extracellular region; membrane; plasma membrane; receptor complex",null,"MET proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=4233","4233",null,null,null,"654328",null,"P08581","D3YVY2","A0A8I6GEH2","A0A8I3NIK6","Q2QLE0","A0A1D5QZ12","GO:0009925; GO:0009986; GO:0005576; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0005008; GO:0042802; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0017154; GO:0016740; GO:0004714","GO:0048754; GO:0016477; GO:0007166; GO:0001886; GO:0061436; GO:0048012; GO:0001889; GO:0010507; GO:1905098; GO:1901299; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0030182; GO:0031016; GO:0018108; GO:0006909; GO:0016310; GO:0050918; GO:2001028; GO:0033674; GO:0031116; GO:0051897; GO:0045944; GO:0006468; GO:0071526; GO:0007165; GO:0007169","PTHR24416:SF483","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7029|UniProtKB=P08581"]
["c-Met (HGF/SF receptor) - phospho","Tyr1234/1235","MET","145","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1946",".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D300., .DRAS., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR RECEPTOR","branching morphogenesis of an epithelial tube; cell migration; cell surface receptor signaling pathway; endothelial cell morphogenesis; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; liver development; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron differentiation; pancreas development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of kinase activity; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; protein phosphorylation; semaphorin-plexin signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; hepatocyte growth factor receptor activity; identical protein binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; semaphorin receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; extracellular region; membrane; plasma membrane; receptor complex",null,"MET proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=4233","4233",null,null,null,"654328",null,"P08581","D3YVY2","A0A8I6GEH2","A0A8I3NIK6","Q2QLE0","A0A1D5QZ12","GO:0009925; GO:0009986; GO:0005576; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0005008; GO:0042802; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0017154; GO:0016740; GO:0004714","GO:0048754; GO:0016477; GO:0007166; GO:0001886; GO:0061436; GO:0048012; GO:0001889; GO:0010507; GO:1905098; GO:1901299; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0030182; GO:0031016; GO:0018108; GO:0006909; GO:0016310; GO:0050918; GO:2001028; GO:0033674; GO:0031116; GO:0051897; GO:0045944; GO:0006468; GO:0071526; GO:0007165; GO:0007169","PTHR24416:SF483","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7029|UniProtKB=P08581"]
["c-Met (HGF/SF receptor) - phospho","Tyr1234/Tyr1235","MET","145","rb",null,7,2,4,4,4,4,"# 0750",".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR RECEPTOR","branching morphogenesis of an epithelial tube; cell migration; cell surface receptor signaling pathway; endothelial cell morphogenesis; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; liver development; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron differentiation; pancreas development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of kinase activity; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; protein phosphorylation; semaphorin-plexin signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; hepatocyte growth factor receptor activity; identical protein binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; semaphorin receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; extracellular region; membrane; plasma membrane; receptor complex","Tyrosine kinase / adaptor / protooncogene","MET proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=4233","4233",null,null,null,"654328",null,"P08581","D3YVY2","A0A8I6GEH2","A0A8I3NIK6","Q2QLE0","A0A1D5QZ12","GO:0009925; GO:0009986; GO:0005576; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0005008; GO:0042802; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0017154; GO:0016740; GO:0004714","GO:0048754; GO:0016477; GO:0007166; GO:0001886; GO:0061436; GO:0048012; GO:0001889; GO:0010507; GO:1905098; GO:1901299; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0030182; GO:0031016; GO:0018108; GO:0006909; GO:0016310; GO:0050918; GO:2001028; GO:0033674; GO:0031116; GO:0051897; GO:0045944; GO:0006468; GO:0071526; GO:0007165; GO:0007169","PTHR24416:SF483","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7029|UniProtKB=P08581"]
["c-Met (HGF/SF receptor) - phospho","Tyr1349","MET","145","rb",null,2,6,4,4,4,7,"# 0754",".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR RECEPTOR","branching morphogenesis of an epithelial tube; cell migration; cell surface receptor signaling pathway; endothelial cell morphogenesis; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; liver development; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron differentiation; pancreas development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of kinase activity; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; protein phosphorylation; semaphorin-plexin signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; hepatocyte growth factor receptor activity; identical protein binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; semaphorin receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; extracellular region; membrane; plasma membrane; receptor complex","Tyrosine kinase / adaptor / protooncogene","MET proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=4233","4233",null,null,null,"654328",null,"P08581","D3YVY2","A0A8I6GEH2","A0A8I3NIK6","Q2QLE0","A0A1D5QZ12","GO:0009925; GO:0009986; GO:0005576; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0005008; GO:0042802; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0017154; GO:0016740; GO:0004714","GO:0048754; GO:0016477; GO:0007166; GO:0001886; GO:0061436; GO:0048012; GO:0001889; GO:0010507; GO:1905098; GO:1901299; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0030182; GO:0031016; GO:0018108; GO:0006909; GO:0016310; GO:0050918; GO:2001028; GO:0033674; GO:0031116; GO:0051897; GO:0045944; GO:0006468; GO:0071526; GO:0007165; GO:0007169","PTHR24416:SF483","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7029|UniProtKB=P08581"]
["c-Met (HGF/SF receptor) - phospho","Tyr1349","MET","145","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1900",".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D300., .DRAS., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR RECEPTOR","branching morphogenesis of an epithelial tube; cell migration; cell surface receptor signaling pathway; endothelial cell morphogenesis; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; liver development; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron differentiation; pancreas development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of kinase activity; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; protein phosphorylation; semaphorin-plexin signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; hepatocyte growth factor receptor activity; identical protein binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; semaphorin receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; extracellular region; membrane; plasma membrane; receptor complex","Tyrosine kinase / adaptor / protooncogene","MET proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=4233","4233",null,null,null,"654328",null,"P08581","D3YVY2","A0A8I6GEH2","A0A8I3NIK6","Q2QLE0","A0A1D5QZ12","GO:0009925; GO:0009986; GO:0005576; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0005008; GO:0042802; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0017154; GO:0016740; GO:0004714","GO:0048754; GO:0016477; GO:0007166; GO:0001886; GO:0061436; GO:0048012; GO:0001889; GO:0010507; GO:1905098; GO:1901299; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0030182; GO:0031016; GO:0018108; GO:0006909; GO:0016310; GO:0050918; GO:2001028; GO:0033674; GO:0031116; GO:0051897; GO:0045944; GO:0006468; GO:0071526; GO:0007165; GO:0007169","PTHR24416:SF483","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7029|UniProtKB=P08581"]
["c-Met (HGF/SF receptor) - phospho","Tyr1349","MET","145","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1933",".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR RECEPTOR","branching morphogenesis of an epithelial tube; cell migration; cell surface receptor signaling pathway; endothelial cell morphogenesis; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; liver development; negative regulation of autophagy; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron differentiation; pancreas development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive chemotaxis; positive regulation of endothelial cell chemotaxis; positive regulation of kinase activity; positive regulation of microtubule polymerization; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; protein phosphorylation; semaphorin-plexin signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; hepatocyte growth factor receptor activity; identical protein binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; semaphorin receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; extracellular region; membrane; plasma membrane; receptor complex",null,"MET proto-oncogene, receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=4233","4233",null,null,null,"654328",null,"P08581","D3YVY2","A0A8I6GEH2","A0A8I3NIK6","Q2QLE0","A0A1D5QZ12","GO:0009925; GO:0009986; GO:0005576; GO:0016020; GO:0005886; GO:0043235","GO:0005524; GO:0005008; GO:0042802; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0017154; GO:0016740; GO:0004714","GO:0048754; GO:0016477; GO:0007166; GO:0001886; GO:0061436; GO:0048012; GO:0001889; GO:0010507; GO:1905098; GO:1901299; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0030182; GO:0031016; GO:0018108; GO:0006909; GO:0016310; GO:0050918; GO:2001028; GO:0033674; GO:0031116; GO:0051897; GO:0045944; GO:0006468; GO:0071526; GO:0007165; GO:0007169","PTHR24416:SF483","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7029|UniProtKB=P08581"]
["c-Myc",null,"MYC","70-57","rb",null,2,2,6,6,2,6,"# 1717",".AML., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DRAS., .DRR., .EGFR., .EMC., .HEPB., .HIF., .HIPPO., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .PDGF., .PI3K., .RTK., .SCLC., .SREME., .STAT., .TGFB., .TRASR., .TYR., .WNT.","CCKR signaling map; Interleukin signaling pathway; PDGF signaling pathway; Oxidative stress response; p53 pathway feedback loops 2; Wnt signaling pathway","MYC PROTO-ONCOGENE PROTEIN","branching involved in ureteric bud morphogenesis; cellular iron ion homeostasis; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to UV; cellular response to xenobiotic stimulus; chromatin remodeling; chromosome organization; energy reserve metabolic process; ERK1 and ERK2 cascade; fibroblast apoptotic process; G1/S transition of mitotic cell cycle; MAPK cascade; negative regulation of apoptotic process; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; oxygen transport; positive regulation of cell population proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA biosynthetic process; positive regulation of DNA methylation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of miRNA transcription; positive regulation of response to DNA damage stimulus; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; protein-DNA complex disassembly; regulation of cell cycle process; regulation of DNA-templated transcription; regulation of gene expression; regulation of somatic stem cell population maintenance; regulation of telomere maintenance; regulation of transcription by RNA polymerase II; response to gamma radiation; response to growth factor; response to xenobiotic stimulus","core promoter sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; protein dimerization activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription coregulator binding; transcription regulator activator activity","chromatin; Myc-Max complex; nucleolus; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex","Transcription factor / protooncogene","MYC proto-oncogene, bHLH transcription factor","http://www.ncbi.nlm.nih.gov/gene/?term=4609","4609","17869",null,null,null,"694626","P01106","P01108","A0A8L2Q2H7","A0A8I3NLI9","A0A5G2QN58","B8XIA5","GO:0000785; GO:0071943; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0001046; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0070888; GO:0005515; GO:0046983; GO:0044877; GO:0000978; GO:0001221; GO:0140537","GO:0001658; GO:0006879; GO:0006974; GO:0071456; GO:0034644; GO:0071466; GO:0006338; GO:0051276; GO:0006112; GO:0070371; GO:0044346; GO:0000082; GO:0000165; GO:0043066; GO:0051782; GO:0048147; GO:0045656; GO:0032873; GO:0000122; GO:0015671; GO:0008284; GO:0043280; GO:2000573; GO:1905643; GO:0045893; GO:0050679; GO:0048146; GO:0010628; GO:1902255; GO:0002053; GO:0090096; GO:1902895; GO:2001022; GO:0051973; GO:0045944; GO:0032986; GO:0010564; GO:0006355; GO:0010468; GO:1904672; GO:0032204; GO:0006357; GO:0010332; GO:0070848; GO:0009410","PTHR45851:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7553|UniProtKB=P01106","P06959; P00036; P00047; P00046; P04398; P00057"]
["c-Myc - phospho","Ser62","MYC","62","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2352",".AML., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DRAS., .DRR., .EGFR., .EMC., .HEPB., .HIF., .HIPPO., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .PDGF., .PI3K., .RTK., .SCLC., .SREME., .STAT., .TGFB., .TRASR., .TYR., .WNT.","CCKR signaling map; Interleukin signaling pathway; PDGF signaling pathway; Oxidative stress response; p53 pathway feedback loops 2; Wnt signaling pathway","MYC PROTO-ONCOGENE PROTEIN","branching involved in ureteric bud morphogenesis; cellular iron ion homeostasis; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to UV; cellular response to xenobiotic stimulus; chromatin remodeling; chromosome organization; energy reserve metabolic process; ERK1 and ERK2 cascade; fibroblast apoptotic process; G1/S transition of mitotic cell cycle; MAPK cascade; negative regulation of apoptotic process; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; oxygen transport; positive regulation of cell population proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA biosynthetic process; positive regulation of DNA methylation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of miRNA transcription; positive regulation of response to DNA damage stimulus; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; protein-DNA complex disassembly; regulation of cell cycle process; regulation of DNA-templated transcription; regulation of gene expression; regulation of somatic stem cell population maintenance; regulation of telomere maintenance; regulation of transcription by RNA polymerase II; response to gamma radiation; response to growth factor; response to xenobiotic stimulus","core promoter sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; protein dimerization activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription coregulator binding; transcription regulator activator activity","chromatin; Myc-Max complex; nucleolus; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex",null,"MYC proto-oncogene, bHLH transcription factor","http://www.ncbi.nlm.nih.gov/gene/?term=4609","4609","17869",null,null,null,"694626","P01106","P01108","A0A8L2Q2H7","A0A8I3NLI9","A0A5G2QN58","B8XIA5","GO:0000785; GO:0071943; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0001046; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0070888; GO:0005515; GO:0046983; GO:0044877; GO:0000978; GO:0001221; GO:0140537","GO:0001658; GO:0006879; GO:0006974; GO:0071456; GO:0034644; GO:0071466; GO:0006338; GO:0051276; GO:0006112; GO:0070371; GO:0044346; GO:0000082; GO:0000165; GO:0043066; GO:0051782; GO:0048147; GO:0045656; GO:0032873; GO:0000122; GO:0015671; GO:0008284; GO:0043280; GO:2000573; GO:1905643; GO:0045893; GO:0050679; GO:0048146; GO:0010628; GO:1902255; GO:0002053; GO:0090096; GO:1902895; GO:2001022; GO:0051973; GO:0045944; GO:0032986; GO:0010564; GO:0006355; GO:0010468; GO:1904672; GO:0032204; GO:0006357; GO:0010332; GO:0070848; GO:0009410","PTHR45851:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7553|UniProtKB=P01106","P06959; P00036; P00047; P00046; P04398; P00057"]
["c-Myc - phospho","Thr58","MYC","62","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2398",".AML., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DRAS., .DRR., .EGFR., .EMC., .HEPB., .HIF., .HIPPO., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .PDGF., .PI3K., .RTK., .SCLC., .SREME., .STAT., .TGFB., .TRASR., .TYR., .WNT.","CCKR signaling map; Interleukin signaling pathway; PDGF signaling pathway; Oxidative stress response; p53 pathway feedback loops 2; Wnt signaling pathway","MYC PROTO-ONCOGENE PROTEIN","branching involved in ureteric bud morphogenesis; cellular iron ion homeostasis; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to UV; cellular response to xenobiotic stimulus; chromatin remodeling; chromosome organization; energy reserve metabolic process; ERK1 and ERK2 cascade; fibroblast apoptotic process; G1/S transition of mitotic cell cycle; MAPK cascade; negative regulation of apoptotic process; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; oxygen transport; positive regulation of cell population proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA biosynthetic process; positive regulation of DNA methylation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of miRNA transcription; positive regulation of response to DNA damage stimulus; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; protein-DNA complex disassembly; regulation of cell cycle process; regulation of DNA-templated transcription; regulation of gene expression; regulation of somatic stem cell population maintenance; regulation of telomere maintenance; regulation of transcription by RNA polymerase II; response to gamma radiation; response to growth factor; response to xenobiotic stimulus","core promoter sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; protein dimerization activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription coregulator binding; transcription regulator activator activity","chromatin; Myc-Max complex; nucleolus; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex",null,"MYC proto-oncogene, bHLH transcription factor","http://www.ncbi.nlm.nih.gov/gene/?term=4609","4609","17869",null,null,null,"694626","P01106","P01108","A0A8L2Q2H7","A0A8I3NLI9","A0A5G2QN58","B8XIA5","GO:0000785; GO:0071943; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0001046; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0070888; GO:0005515; GO:0046983; GO:0044877; GO:0000978; GO:0001221; GO:0140537","GO:0001658; GO:0006879; GO:0006974; GO:0071456; GO:0034644; GO:0071466; GO:0006338; GO:0051276; GO:0006112; GO:0070371; GO:0044346; GO:0000082; GO:0000165; GO:0043066; GO:0051782; GO:0048147; GO:0045656; GO:0032873; GO:0000122; GO:0015671; GO:0008284; GO:0043280; GO:2000573; GO:1905643; GO:0045893; GO:0050679; GO:0048146; GO:0010628; GO:1902255; GO:0002053; GO:0090096; GO:1902895; GO:2001022; GO:0051973; GO:0045944; GO:0032986; GO:0010564; GO:0006355; GO:0010468; GO:1904672; GO:0032204; GO:0006357; GO:0010332; GO:0070848; GO:0009410","PTHR45851:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7553|UniProtKB=P01106","P06959; P00036; P00047; P00046; P04398; P00057"]
["c-Myc - phospho","Thr58/Ser62","MYC","57","rb",null,2.1,4,4,4,4,4,"# 1240",".AML., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DRAS., .DRR., .EGFR., .EMC., .HEPB., .HIF., .HIPPO., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .PDGF., .PI3K., .RTK., .SCLC., .SREME., .STAT., .TGFB., .TRASR., .TYR., .WNT.","CCKR signaling map; Interleukin signaling pathway; PDGF signaling pathway; Oxidative stress response; p53 pathway feedback loops 2; Wnt signaling pathway","MYC PROTO-ONCOGENE PROTEIN","branching involved in ureteric bud morphogenesis; cellular iron ion homeostasis; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to UV; cellular response to xenobiotic stimulus; chromatin remodeling; chromosome organization; energy reserve metabolic process; ERK1 and ERK2 cascade; fibroblast apoptotic process; G1/S transition of mitotic cell cycle; MAPK cascade; negative regulation of apoptotic process; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; oxygen transport; positive regulation of cell population proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA biosynthetic process; positive regulation of DNA methylation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of miRNA transcription; positive regulation of response to DNA damage stimulus; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; protein-DNA complex disassembly; regulation of cell cycle process; regulation of DNA-templated transcription; regulation of gene expression; regulation of somatic stem cell population maintenance; regulation of telomere maintenance; regulation of transcription by RNA polymerase II; response to gamma radiation; response to growth factor; response to xenobiotic stimulus","core promoter sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; protein dimerization activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription coregulator binding; transcription regulator activator activity","chromatin; Myc-Max complex; nucleolus; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex","Transcription factor / protooncogene","MYC proto-oncogene, bHLH transcription factor","http://www.ncbi.nlm.nih.gov/gene/?term=4609","4609","17869",null,null,null,"694626","P01106","P01108","A0A8L2Q2H7","A0A8I3NLI9","A0A5G2QN58","B8XIA5","GO:0000785; GO:0071943; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0001046; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0070888; GO:0005515; GO:0046983; GO:0044877; GO:0000978; GO:0001221; GO:0140537","GO:0001658; GO:0006879; GO:0006974; GO:0071456; GO:0034644; GO:0071466; GO:0006338; GO:0051276; GO:0006112; GO:0070371; GO:0044346; GO:0000082; GO:0000165; GO:0043066; GO:0051782; GO:0048147; GO:0045656; GO:0032873; GO:0000122; GO:0015671; GO:0008284; GO:0043280; GO:2000573; GO:1905643; GO:0045893; GO:0050679; GO:0048146; GO:0010628; GO:1902255; GO:0002053; GO:0090096; GO:1902895; GO:2001022; GO:0051973; GO:0045944; GO:0032986; GO:0010564; GO:0006355; GO:0010468; GO:1904672; GO:0032204; GO:0006357; GO:0010332; GO:0070848; GO:0009410","PTHR45851:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7553|UniProtKB=P01106","P06959; P00036; P00047; P00046; P04398; P00057"]
["Cofilin",null,"CFL1","19","rb",null,1,1,1,1,1,1,"# 1004",".APO., .CCP., .CCY., .CD., .CSP., .IMUR., .OP., .RAS., .RTK., .VIR.","Cytoskeletal regulation by Rho GTPase","COFILIN-1","actin cytoskeleton organization; actin filament depolymerization; actin filament fragmentation; actin filament severing; cytoskeleton organization; establishment of spindle localization; mitotic cytokinesis; negative regulation of apoptotic process; positive regulation by host of viral process; positive regulation of embryonic development; regulation of cell morphogenesis; regulation of dendritic spine morphogenesis; response to virus; Rho protein signal transduction","actin binding; actin filament binding; protein binding","actin cytoskeleton; axon; cell projection; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular space; focal adhesion; growth cone; lamellipodium; lamellipodium membrane; membrane; nuclear matrix; nucleus; plasma membrane; ruffle membrane; vesicle","Cytoskeletal signaling","cofilin 1","http://www.ncbi.nlm.nih.gov/gene/?term=1072","1072","12631","29271","476022","445532",null,"P23528","P18760","P45592","A0A8I3P3F3","P10668","A0A1D5QNJ4","GO:0015629; GO:0030424; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005615; GO:0005925; GO:0030426; GO:0030027; GO:0031258; GO:0016020; GO:0016363; GO:0005634; GO:0005886; GO:0032587; GO:0031982","GO:0003779; GO:0051015; GO:0005515","GO:0030036; GO:0030042; GO:0030043; GO:0051014; GO:0007010; GO:0051293; GO:0000281; GO:0043066; GO:0044794; GO:0040019; GO:0022604; GO:0061001; GO:0009615; GO:0007266","PTHR11913:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1874|UniProtKB=P23528","P00016"]
["Cofilin - phospho","Ser3","CFL1","19","rb",null,1,1,8,8,8,8,"# 1006",".APO., .CCP., .CCY., .CD., .CSP., .IMUR., .OP., .RAS., .RTK., .VIR.","Cytoskeletal regulation by Rho GTPase","COFILIN-1","actin cytoskeleton organization; actin filament depolymerization; actin filament fragmentation; actin filament severing; cytoskeleton organization; establishment of spindle localization; mitotic cytokinesis; negative regulation of apoptotic process; positive regulation by host of viral process; positive regulation of embryonic development; regulation of cell morphogenesis; regulation of dendritic spine morphogenesis; response to virus; Rho protein signal transduction","actin binding; actin filament binding; protein binding","actin cytoskeleton; axon; cell projection; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular space; focal adhesion; growth cone; lamellipodium; lamellipodium membrane; membrane; nuclear matrix; nucleus; plasma membrane; ruffle membrane; vesicle","Cytoskeletal signaling","cofilin 1","http://www.ncbi.nlm.nih.gov/gene/?term=1072","1072","12631","29271","476022","445532",null,"P23528","P18760","P45592","A0A8I3P3F3","P10668","A0A1D5QNJ4","GO:0015629; GO:0030424; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005615; GO:0005925; GO:0030426; GO:0030027; GO:0031258; GO:0016020; GO:0016363; GO:0005634; GO:0005886; GO:0032587; GO:0031982","GO:0003779; GO:0051015; GO:0005515","GO:0030036; GO:0030042; GO:0030043; GO:0051014; GO:0007010; GO:0051293; GO:0000281; GO:0043066; GO:0044794; GO:0040019; GO:0022604; GO:0061001; GO:0009615; GO:0007266","PTHR11913:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1874|UniProtKB=P23528","P00016"]
["COL1A2",null,"COL1A2","129","rb",null,5,5,"n/a","n/a","n/a","n/a","# 1159",".CSP., .DEV., .INT., .OP., .OPA., .OT., .PI3K., .PLAT., .RAS., .RTK., .TGFB.","Integrin signalling pathway","COLLAGEN ALPHA-2(I) CHAIN","blood vessel development; bone mineralization; cellular response to amino acid stimulus; collagen fibril organization; collagen metabolic process; extracellular matrix assembly; extracellular matrix organization; odontogenesis; protein heterotrimerization; regulation of blood pressure; Rho protein signal transduction; skeletal system development; skin morphogenesis; transforming growth factor beta receptor signaling pathway","extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; identical protein binding; metal ion binding; platelet-derived growth factor binding; protease binding; protein binding; protein-macromolecule adaptor activity; SMAD binding","collagen trimer; collagen type I trimer; collagen-containing extracellular matrix; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular exosome; extracellular matrix; extracellular region; extracellular space","Extracellular matrix","collagen type I alpha 2 chain","http://www.ncbi.nlm.nih.gov/gene/?term=1278","1278","12843",null,null,null,null,"P08123","Q01149","A0A0G2K5E8","A0A8I3P1L4","A0A8W4FM91","A0A1D5R5K5","GO:0005581; GO:0005584; GO:0062023; GO:0005783; GO:0005788; GO:0070062; GO:0031012; GO:0005576; GO:0005615","GO:0005201; GO:0030020; GO:0042802; GO:0046872; GO:0048407; GO:0002020; GO:0005515; GO:0030674; GO:0046332","GO:0001568; GO:0030282; GO:0071230; GO:0030199; GO:0032963; GO:0085029; GO:0030198; GO:0042476; GO:0070208; GO:0008217; GO:0007266; GO:0001501; GO:0043589; GO:0007179","PTHR24023:SF568","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2198|UniProtKB=P08123","P00034"]
["COL1A2",null,"COL1A2","125","rb",null,6,4,"n/a","n/a","n/a","n/a","# 2263",".CSP., .DEV., .INT., .OP., .OPA., .OT., .PI3K., .PLAT., .RAS., .RTK., .TGFB.","Integrin signalling pathway","COLLAGEN ALPHA-2(I) CHAIN","blood vessel development; bone mineralization; cellular response to amino acid stimulus; collagen fibril organization; collagen metabolic process; extracellular matrix assembly; extracellular matrix organization; odontogenesis; protein heterotrimerization; regulation of blood pressure; Rho protein signal transduction; skeletal system development; skin morphogenesis; transforming growth factor beta receptor signaling pathway","extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; identical protein binding; metal ion binding; platelet-derived growth factor binding; protease binding; protein binding; protein-macromolecule adaptor activity; SMAD binding","collagen trimer; collagen type I trimer; collagen-containing extracellular matrix; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular exosome; extracellular matrix; extracellular region; extracellular space","Extracellular matrix","collagen type I alpha 2 chain","http://www.ncbi.nlm.nih.gov/gene/?term=1278","1278","12843",null,null,null,null,"P08123","Q01149","A0A0G2K5E8","A0A8I3P1L4","A0A8W4FM91","A0A1D5R5K5","GO:0005581; GO:0005584; GO:0062023; GO:0005783; GO:0005788; GO:0070062; GO:0031012; GO:0005576; GO:0005615","GO:0005201; GO:0030020; GO:0042802; GO:0046872; GO:0048407; GO:0002020; GO:0005515; GO:0030674; GO:0046332","GO:0001568; GO:0030282; GO:0071230; GO:0030199; GO:0032963; GO:0085029; GO:0030198; GO:0042476; GO:0070208; GO:0008217; GO:0007266; GO:0001501; GO:0043589; GO:0007179","PTHR24023:SF568","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2198|UniProtKB=P08123","P00034"]
["Connexin 26",null,"GJB2","27","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1085",".CSP., .DRR., .OP., .OPA., .OT., .OXS., .SREME., .ST.",null,"GAP JUNCTION BETA-2 PROTEIN","aging; cell communication; cell communication by electrical coupling; cell-cell signaling; cellular response to dexamethasone stimulus; cellular response to glucagon stimulus; cellular response to oxidative stress; decidualization; epididymis development; female pregnancy; gap junction assembly; gap junction-mediated intercellular transport; inner ear development; response to antibiotic; response to estradiol; response to human chorionic gonadotropin; response to ischemia; response to lipopolysaccharide; response to progesterone; response to retinoic acid; sensory perception of sound; transmembrane transport","calcium ion binding; gap junction channel activity; gap junction channel activity involved in cell communication by electrical coupling; identical protein binding; metal ion binding; protein binding","anchoring junction; astrocyte projection; cell body; cell junction; connexin complex; cytoplasm; cytosol; endoplasmic reticulum-Golgi intermediate compartment; gap junction; lateral plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane","Cell-cell interaction","gap junction protein beta 2","http://www.ncbi.nlm.nih.gov/gene/?term=2706","2706","14619","394266","403570",null,"704224","P29033","Q00977","P21994","J9NXR5",null,"Q8MIT8","GO:0070161; GO:0097449; GO:0044297; GO:0030054; GO:0005922; GO:0005737; GO:0005829; GO:0005793; GO:0005921; GO:0016328; GO:0016020; GO:0048471; GO:0005886","GO:0005509; GO:0005243; GO:1903763; GO:0042802; GO:0046872; GO:0005515","GO:0007568; GO:0007154; GO:0010644; GO:0007267; GO:0071549; GO:0071377; GO:0034599; GO:0046697; GO:1905867; GO:0007565; GO:0016264; GO:1990349; GO:0048839; GO:0046677; GO:0032355; GO:0044752; GO:0002931; GO:0032496; GO:0032570; GO:0032526; GO:0007605; GO:0055085","PTHR11984:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4284|UniProtKB=P29033"]
["Connexin 32",null,"GJB1","32","ms",null,2,4,7,7,7,7,"# 1053",".CSP., .OPA., .ST.",null,"GAP JUNCTION BETA-1 PROTEIN","cell communication; cell-cell signaling; epididymis development; gap junction assembly; nervous system development; purine ribonucleotide transport; transmembrane transport","gap junction channel activity; identical protein binding; protein binding","anchoring junction; connexin complex; cytoplasm; endoplasmic reticulum membrane; gap junction; lateral plasma membrane; membrane; plasma membrane; protein-containing complex","Cell-cell interaction","gap junction protein beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=2705","2705","14618",null,"480953","100519581","706327","P08034","P28230",null,"E2QYR1","F1RSW9","G7NRV4","GO:0070161; GO:0005922; GO:0005737; GO:0005789; GO:0005921; GO:0016328; GO:0016020; GO:0005886; GO:0032991","GO:0005243; GO:0042802; GO:0005515","GO:0007154; GO:0007267; GO:1905867; GO:0016264; GO:0007399; GO:0015868; GO:0055085","PTHR11984:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4283|UniProtKB=P08034"]
["Connexin 43",null,"GJA1","44, 43, 41, 39","rb",null,1,4,4,4,4,4,"# 1047",".CCP., .CP., .CSP., .IMUF., .MIG., .NFKB., .OP., .OPA., .OT., .ST., .TRASR.",null,"GAP JUNCTION ALPHA-1 PROTEIN","atrial cardiac muscle cell action potential; bone development; bone remodeling; cardiac conduction system development; cell communication; cell communication by electrical coupling; cell communication by electrical coupling involved in cardiac conduction; cell-cell signaling; cellular response to amyloid-beta; establishment of mitotic spindle orientation; export across plasma membrane; gap junction assembly; glutamate secretion; glutathione transmembrane transport; heart development; ion transmembrane transport; maintenance of blood-brain barrier; negative regulation of cell growth; negative regulation of gonadotropin secretion; negative regulation of trophoblast cell migration; positive regulation of cold-induced thermogenesis; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of mesodermal cell differentiation; positive regulation of morphogenesis of an epithelium; positive regulation of stem cell proliferation; positive regulation of vascular associated smooth muscle cell proliferation; protein localization; signal transduction; spermatogenesis; xenobiotic transport","beta-catenin binding; efflux transmembrane transporter activity; gap junction channel activity; gap junction channel activity involved in cardiac conduction electrical coupling; gap junction channel activity involved in cell communication by electrical coupling; gap junction hemi-channel activity; glutathione transmembrane transporter activity; ion transmembrane transporter activity; protein binding; transmembrane transporter activity; tubulin binding","anchoring junction; apical plasma membrane; cell junction; cell-cell contact zone; connexin complex; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; focal adhesion; gap junction; Golgi apparatus; Golgi membrane; Golgi-associated vesicle membrane; intercalated disc; intracellular membrane-bounded organelle; membrane; membrane raft; mitochondrion; nucleoplasm; plasma membrane; tight junction","Cell-cell interaction","gap junction protein alpha 1","http://www.ncbi.nlm.nih.gov/gene/?term=2697","2697","14609","24392","403418","100518636","714344","P17302","P23242","P08050","A0A654IEC4","F1SF43","F7C314","GO:0070161; GO:0016324; GO:0030054; GO:0044291; GO:0005922; GO:0005737; GO:0005783; GO:0005789; GO:0005925; GO:0005921; GO:0005794; GO:0000139; GO:0030660; GO:0014704; GO:0043231; GO:0016020; GO:0045121; GO:0005739; GO:0005654; GO:0005886; GO:0070160","GO:0008013; GO:0015562; GO:0005243; GO:0086075; GO:1903763; GO:0055077; GO:0034634; GO:0015075; GO:0005515; GO:0022857; GO:0015631","GO:0086014; GO:0060348; GO:0046849; GO:0003161; GO:0007154; GO:0010644; GO:0086064; GO:0007267; GO:1904646; GO:0000132; GO:0140115; GO:0016264; GO:0014047; GO:0034775; GO:0007507; GO:0034220; GO:0035633; GO:0030308; GO:0032277; GO:1901164; GO:0120162; GO:0010628; GO:0043123; GO:1905772; GO:1905332; GO:2000648; GO:1904707; GO:0008104; GO:0007165; GO:0007283; GO:0042908","PTHR11984:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4274|UniProtKB=P17302"]
["Contactin 1",null,"CNTN1","135","ms",null,2,7,7,7,7,7,"# 0511",".CSP., .DEV., .NOTCH., .OP., .OPA., .OT., .ST., .TRASR.",null,"CONTACTIN-1","axon guidance; brain development; cell adhesion; cell-cell adhesion; central nervous system myelin formation; cerebellum development; gene expression; locomotory behavior; myelination; neuron projection development; Notch signaling pathway; positive regulation of gene expression; positive regulation of neuron projection development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of sodium ion transport","carbohydrate binding; cell-cell adhesion mediator activity; protein binding","axon; extracellular exosome; membrane; membrane raft; plasma membrane; postsynaptic membrane; presynaptic membrane","Cell adhesion / Notch signaling","contactin 1","http://www.ncbi.nlm.nih.gov/gene/?term=1272","1272","12805","117258",null,"100521555","574365","Q12860","P12960","Q63198","A0A8I3Q4B4","A0A287B9Q3","A0A5F7ZUW4","GO:0030424; GO:0070062; GO:0016020; GO:0045121; GO:0005886; GO:0045211; GO:0042734","GO:0030246; GO:0098632; GO:0005515","GO:0007411; GO:0007420; GO:0007155; GO:0098609; GO:0032289; GO:0021549; GO:0010467; GO:0007626; GO:0042552; GO:0031175; GO:0007219; GO:0010628; GO:0010976; GO:0050731; GO:0010765","PTHR44170:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2171|UniProtKB=Q12860"]
["Cox1",null,"PTGS1","70","rb",null,2,1,1,1,2,2,"# 2632",".CCP., .CP., .CSP., .IMUF., .INFM., .OP., .OT., .PLAT.","Inflammation mediated by chemokine and cytokine signaling pathway","PROSTAGLANDIN G/H SYNTHASE 1","cellular oxidant detoxification; cyclooxygenase pathway; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; organic substance metabolic process; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of blood pressure; regulation of cell population proliferation; response to oxidative stress","dioxygenase activity; heme binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; peroxidase activity; prostaglandin-endoperoxide synthase activity; protein binding","cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular exosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; neuron projection; photoreceptor outer segment","NFkB signaling","prostaglandin-endoperoxide synthase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5742","5742","19224","24693","403544",null,null,"P23219","P22437","Q66HK3","Q8HZR1","A0A287ANF9","A0A1D5Q8P3","GO:0005737; GO:0005783; GO:0005789; GO:0070062; GO:0005794; GO:0043231; GO:0016020; GO:0043005; GO:0001750","GO:0051213; GO:0020037; GO:0046872; GO:0016491; GO:0016702; GO:0004601; GO:0004666; GO:0005515","GO:0098869; GO:0019371; GO:0006633; GO:0006631; GO:0006629; GO:0071704; GO:0001516; GO:0006693; GO:0008217; GO:0042127; GO:0006979","PTHR11903:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9604|UniProtKB=P23219","P00031"]
["Cox2",null,"MT-CO2","74","rb",null,4,4,4,4,4,4,"TK # 094",".ALZ., .DI., .HUNT., .OP.","Gonadotropin releasing hormone receptor pathway","CYTOCHROME C OXIDASE SUBUNIT 2","ATP synthesis coupled electron transport; cellular respiration; electron transport chain; lactation; mitochondrial electron transport, cytochrome c to oxygen; positive regulation of ATP biosynthetic process; positive regulation of hydrogen peroxide biosynthetic process; positive regulation of necrotic cell death; proton transmembrane transport; response to cold","copper ion binding; cytochrome-c oxidase activity; metal ion binding; oxidoreductase activity; protein binding","membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex IV; mitochondrion; respirasome; respiratory chain complex IV","NFkB signaling","mitochondrially encoded cytochrome c oxidase II","http://www.ncbi.nlm.nih.gov/gene/?term=4513","4513","17709","26198",null,"808504",null,"P00403","P00405","P00406",null,"Q69GF7",null,"GO:0016020; GO:0005743; GO:0005751; GO:0005739; GO:0070469; GO:0045277","GO:0005507; GO:0004129; GO:0046872; GO:0016491; GO:0005515","GO:0042773; GO:0045333; GO:0022900; GO:0007595; GO:0006123; GO:2001171; GO:0010729; GO:0010940; GO:1902600; GO:0009409","PTHR22888:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7421|UniProtKB=P00403","P06664"]
["cPLA2",null,"PLA2G4A","95","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2180",".ANG., .CANCER., .CCKR., .CCP., .CP., .CSP., .ENDO., .IMUF., .INFM., .MAPK., .OP., .OPA., .OT., .OXS., .PLAT., .RAS., .RTK., .SREME., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Angiogenesis; Oxidative stress response; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","CYTOSOLIC PHOSPHOLIPASE A2","arachidonic acid metabolic process; arachidonic acid secretion; cellular response to antibiotic; establishment of localization in cell; fatty acid biosynthetic process; fatty acid metabolic process; glycerol metabolic process; glycerophospholipid catabolic process; glycerophospholipid metabolic process; icosanoid biosynthetic process; icosanoid metabolic process; leukotriene biosynthetic process; lipid catabolic process; lipid metabolic process; monoacylglycerol biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylcholine catabolic process; phosphatidylglycerol catabolic process; phospholipid catabolic process; platelet activating factor biosynthetic process; positive regulation of macrophage activation; positive regulation of platelet activation; positive regulation of prostaglandin secretion; positive regulation of T-helper 1 type immune response; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of cell population proliferation","calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; calcium-independent phospholipase A2 activity; ceramide 1-phosphate binding; hydrolase activity; lipid binding; lysophospholipase activity; metal ion binding; O-acyltransferase activity; phosphatidyl phospholipase B activity; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; phospholipase A2 activity; phospholipase activity","cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; membrane; mitochondrial inner membrane; nuclear envelope; nucleus",null,"phospholipase A2 group IVA","http://www.ncbi.nlm.nih.gov/gene/?term=5321","5321","18783",null,"480048","100520687","716635","P47712","P47713","A0A0G2KAA9","A0A8I3MZB9","A0A287AQ26","F7EEZ1","GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0005794; GO:0000139; GO:0043231; GO:0016020; GO:0005743; GO:0005635; GO:0005634","GO:0005509; GO:0047498; GO:0005544; GO:0047499; GO:1902387; GO:0016787; GO:0008289; GO:0004622; GO:0046872; GO:0008374; GO:0102545; GO:0032266; GO:0070273; GO:0010314; GO:0004623; GO:0004620","GO:0019369; GO:0050482; GO:0071236; GO:0051649; GO:0006633; GO:0006631; GO:0006071; GO:0046475; GO:0006650; GO:0046456; GO:0006690; GO:0019370; GO:0016042; GO:0006629; GO:0006640; GO:0036151; GO:0034638; GO:0034478; GO:0009395; GO:0006663; GO:0043032; GO:0010572; GO:0032308; GO:0002827; GO:0001516; GO:0006693; GO:0042127","PTHR10728:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9035|UniProtKB=P47712","P06959; P00056; P06664; P00005; P00046; P00031; P00019"]
["cPLA2",null,"PLA2G4A","98","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2198",".ANG., .CANCER., .CCKR., .CCP., .CP., .CSP., .ENDO., .IMUF., .INFM., .MAPK., .OP., .OPA., .OT., .OXS., .PLAT., .RAS., .RTK., .SREME., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Angiogenesis; Oxidative stress response; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","CYTOSOLIC PHOSPHOLIPASE A2","arachidonic acid metabolic process; arachidonic acid secretion; cellular response to antibiotic; establishment of localization in cell; fatty acid biosynthetic process; fatty acid metabolic process; glycerol metabolic process; glycerophospholipid catabolic process; glycerophospholipid metabolic process; icosanoid biosynthetic process; icosanoid metabolic process; leukotriene biosynthetic process; lipid catabolic process; lipid metabolic process; monoacylglycerol biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylcholine catabolic process; phosphatidylglycerol catabolic process; phospholipid catabolic process; platelet activating factor biosynthetic process; positive regulation of macrophage activation; positive regulation of platelet activation; positive regulation of prostaglandin secretion; positive regulation of T-helper 1 type immune response; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of cell population proliferation","calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; calcium-independent phospholipase A2 activity; ceramide 1-phosphate binding; hydrolase activity; lipid binding; lysophospholipase activity; metal ion binding; O-acyltransferase activity; phosphatidyl phospholipase B activity; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; phospholipase A2 activity; phospholipase activity","cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; membrane; mitochondrial inner membrane; nuclear envelope; nucleus",null,"phospholipase A2 group IVA","http://www.ncbi.nlm.nih.gov/gene/?term=5321","5321","18783",null,"480048","100520687","716635","P47712","P47713","A0A0G2KAA9","A0A8I3MZB9","A0A287AQ26","F7EEZ1","GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0005794; GO:0000139; GO:0043231; GO:0016020; GO:0005743; GO:0005635; GO:0005634","GO:0005509; GO:0047498; GO:0005544; GO:0047499; GO:1902387; GO:0016787; GO:0008289; GO:0004622; GO:0046872; GO:0008374; GO:0102545; GO:0032266; GO:0070273; GO:0010314; GO:0004623; GO:0004620","GO:0019369; GO:0050482; GO:0071236; GO:0051649; GO:0006633; GO:0006631; GO:0006071; GO:0046475; GO:0006650; GO:0046456; GO:0006690; GO:0019370; GO:0016042; GO:0006629; GO:0006640; GO:0036151; GO:0034638; GO:0034478; GO:0009395; GO:0006663; GO:0043032; GO:0010572; GO:0032308; GO:0002827; GO:0001516; GO:0006693; GO:0042127","PTHR10728:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9035|UniProtKB=P47712","P06959; P00056; P06664; P00005; P00046; P00031; P00019"]
["cPLA2 - phospho","Ser505","PLA2G4A","95","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2179",".ANG., .CANCER., .CCKR., .CCP., .CP., .CSP., .ENDO., .IMUF., .INFM., .MAPK., .OP., .OPA., .OT., .OXS., .PLAT., .RAS., .RTK., .SREME., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Angiogenesis; Oxidative stress response; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","CYTOSOLIC PHOSPHOLIPASE A2","arachidonic acid metabolic process; arachidonic acid secretion; cellular response to antibiotic; establishment of localization in cell; fatty acid biosynthetic process; fatty acid metabolic process; glycerol metabolic process; glycerophospholipid catabolic process; glycerophospholipid metabolic process; icosanoid biosynthetic process; icosanoid metabolic process; leukotriene biosynthetic process; lipid catabolic process; lipid metabolic process; monoacylglycerol biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylcholine catabolic process; phosphatidylglycerol catabolic process; phospholipid catabolic process; platelet activating factor biosynthetic process; positive regulation of macrophage activation; positive regulation of platelet activation; positive regulation of prostaglandin secretion; positive regulation of T-helper 1 type immune response; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of cell population proliferation","calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; calcium-independent phospholipase A2 activity; ceramide 1-phosphate binding; hydrolase activity; lipid binding; lysophospholipase activity; metal ion binding; O-acyltransferase activity; phosphatidyl phospholipase B activity; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; phospholipase A2 activity; phospholipase activity","cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; membrane; mitochondrial inner membrane; nuclear envelope; nucleus",null,"phospholipase A2 group IVA","http://www.ncbi.nlm.nih.gov/gene/?term=5321","5321","18783",null,"480048","100520687","716635","P47712","P47713","A0A0G2KAA9","A0A8I3MZB9","A0A287AQ26","F7EEZ1","GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0005794; GO:0000139; GO:0043231; GO:0016020; GO:0005743; GO:0005635; GO:0005634","GO:0005509; GO:0047498; GO:0005544; GO:0047499; GO:1902387; GO:0016787; GO:0008289; GO:0004622; GO:0046872; GO:0008374; GO:0102545; GO:0032266; GO:0070273; GO:0010314; GO:0004623; GO:0004620","GO:0019369; GO:0050482; GO:0071236; GO:0051649; GO:0006633; GO:0006631; GO:0006071; GO:0046475; GO:0006650; GO:0046456; GO:0006690; GO:0019370; GO:0016042; GO:0006629; GO:0006640; GO:0036151; GO:0034638; GO:0034478; GO:0009395; GO:0006663; GO:0043032; GO:0010572; GO:0032308; GO:0002827; GO:0001516; GO:0006693; GO:0042127","PTHR10728:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9035|UniProtKB=P47712","P06959; P00056; P06664; P00005; P00046; P00031; P00019"]
["CPS1",null,"CPS1","165","gt",null,7,1,"n/a","n/a","n/a","n/a","# 1597",".cAMP., .CSP., .DRR., .GPCR., .OP., .OT.","De novo pyrmidine ribonucleotides biosythesis; Arginine biosynthesis","CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL","anion homeostasis; carbamoyl phosphate biosynthetic process; cellular response to ammonium ion; cellular response to cAMP; cellular response to fibroblast growth factor stimulus; cellular response to glucagon stimulus; cellular response to oleic acid; citrulline biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; glutamine metabolic process; hepatocyte differentiation; homocysteine metabolic process; liver development; metabolic process; midgut development; nitric oxide metabolic process; nitrogen compound metabolic process; response to amine; response to amino acid; response to cAMP; response to dexamethasone; response to food; response to glucagon; response to glucocorticoid; response to growth hormone; response to lipopolysaccharide; response to oleic acid; response to starvation; response to steroid hormone; response to toxic substance; response to xenobiotic stimulus; response to zinc ion; sequestering of metal ion; triglyceride catabolic process; urea cycle; vasodilation","ATP binding; calcium ion binding; carbamoyl-phosphate synthase (ammonia) activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; catalytic activity; endopeptidase activity; glutamate binding; ligase activity; metal ion binding; modified amino acid binding; nucleotide binding; phospholipid binding; protein binding; protein-containing complex binding; small molecule binding","cytoplasm; mitochondrial inner membrane; mitochondrial matrix; mitochondrial nucleoid; mitochondrion; nucleolus; nucleus; protein-containing complex",null,"carbamoyl-phosphate synthase 1","http://www.ncbi.nlm.nih.gov/gene/?term=1373","1373","227231","497840",null,null,null,"P31327","Q8C196","P07756","A0A8I3P552","A0A287B4L9","A0A5F8A1Z4","GO:0005737; GO:0005743; GO:0005759; GO:0042645; GO:0005739; GO:0005730; GO:0005634; GO:0032991","GO:0005524; GO:0005509; GO:0004087; GO:0004088; GO:0003824; GO:0004175; GO:0016595; GO:0016874; GO:0046872; GO:0072341; GO:0000166; GO:0005543; GO:0005515; GO:0044877; GO:0036094","GO:0055081; GO:0070409; GO:0071242; GO:0071320; GO:0044344; GO:0071377; GO:0071400; GO:0019240; GO:0006207; GO:0006541; GO:0070365; GO:0050667; GO:0001889; GO:0008152; GO:0007494; GO:0046209; GO:0006807; GO:0014075; GO:0043200; GO:0051591; GO:0071548; GO:0032094; GO:0033762; GO:0051384; GO:0060416; GO:0032496; GO:0034201; GO:0042594; GO:0048545; GO:0009636; GO:0009410; GO:0010043; GO:0051238; GO:0019433; GO:0000050; GO:0042311","PTHR11405:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2323|UniProtKB=P31327","P02740; P02728"]
["c-Raf",null,"RAF1","75-65","rb",null,2,1,1.1000000000000001,1,1,1,"# 2799",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TD., .TMAT., .TRASR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE","activation of adenylate cyclase activity; apoptotic process; cell differentiation; cellular glucose homeostasis; death-inducing signaling complex assembly; extrinsic apoptotic signaling pathway via death domain receptors; face development; insulin receptor signaling pathway; insulin secretion involved in cellular response to glucose stimulus; insulin-like growth factor receptor signaling pathway; intermediate filament cytoskeleton organization; MAPK cascade; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of protein-containing complex assembly; neurotrophin TRK receptor signaling pathway; phosphorylation; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein modification process; protein phosphorylation; regulation of apoptotic process; regulation of cell differentiation; regulation of cell motility; regulation of Rho protein signal transduction; response to muscle stretch; signal transduction; somatic stem cell population maintenance; thymus development; thyroid gland development; type B pancreatic cell proliferation; wound healing","ATP binding; enzyme binding; identical protein binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity","cytoplasm; cytosol; Golgi apparatus; membrane; mitochondrial outer membrane; mitochondrion; nucleus; plasma membrane; pseudopodium","MAPK signaling","Raf-1 proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=5894","5894","110157","24703","484648",null,null,"P04049","Q99N57","P11345","A0A8I3PZA0","A0A287AZ70","A0A1D5QK38","GO:0005737; GO:0005829; GO:0005794; GO:0016020; GO:0005741; GO:0005739; GO:0005634; GO:0005886; GO:0031143","GO:0005524; GO:0019899; GO:0042802; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0043539; GO:0004674; GO:0031267; GO:0016740","GO:0007190; GO:0006915; GO:0030154; GO:0001678; GO:0071550; GO:0008625; GO:0060324; GO:0008286; GO:0035773; GO:0048009; GO:0045104; GO:0000165; GO:0043066; GO:0008285; GO:0043154; GO:1902042; GO:0031333; GO:0048011; GO:0016310; GO:0043410; GO:0033138; GO:0001934; GO:0045944; GO:0036211; GO:0006468; GO:0042981; GO:0045595; GO:2000145; GO:0035023; GO:0035994; GO:0007165; GO:0035019; GO:0048538; GO:0030878; GO:0044342; GO:0042060","PTHR44329:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9829|UniProtKB=P04049","P06959; P00053; P00032; P00010; P00056; P00036; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00018; P00031; P00019"]
["c-Raf - phospho","Ser259","RAF1","74","rb",null,2,2,2,8,2.1,1.1000000000000001,"# 2054",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TD., .TMAT., .TRASR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE","activation of adenylate cyclase activity; apoptotic process; cell differentiation; cellular glucose homeostasis; death-inducing signaling complex assembly; extrinsic apoptotic signaling pathway via death domain receptors; face development; insulin receptor signaling pathway; insulin secretion involved in cellular response to glucose stimulus; insulin-like growth factor receptor signaling pathway; intermediate filament cytoskeleton organization; MAPK cascade; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of protein-containing complex assembly; neurotrophin TRK receptor signaling pathway; phosphorylation; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein modification process; protein phosphorylation; regulation of apoptotic process; regulation of cell differentiation; regulation of cell motility; regulation of Rho protein signal transduction; response to muscle stretch; signal transduction; somatic stem cell population maintenance; thymus development; thyroid gland development; type B pancreatic cell proliferation; wound healing","ATP binding; enzyme binding; identical protein binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity","cytoplasm; cytosol; Golgi apparatus; membrane; mitochondrial outer membrane; mitochondrion; nucleus; plasma membrane; pseudopodium","MAPK signaling","Raf-1 proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=5894","5894","110157","24703","484648",null,null,"P04049","Q99N57","P11345","A0A8I3PZA0","A0A287AZ70","A0A1D5QK38","GO:0005737; GO:0005829; GO:0005794; GO:0016020; GO:0005741; GO:0005739; GO:0005634; GO:0005886; GO:0031143","GO:0005524; GO:0019899; GO:0042802; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0043539; GO:0004674; GO:0031267; GO:0016740","GO:0007190; GO:0006915; GO:0030154; GO:0001678; GO:0071550; GO:0008625; GO:0060324; GO:0008286; GO:0035773; GO:0048009; GO:0045104; GO:0000165; GO:0043066; GO:0008285; GO:0043154; GO:1902042; GO:0031333; GO:0048011; GO:0016310; GO:0043410; GO:0033138; GO:0001934; GO:0045944; GO:0036211; GO:0006468; GO:0042981; GO:0045595; GO:2000145; GO:0035023; GO:0035994; GO:0007165; GO:0035019; GO:0048538; GO:0030878; GO:0044342; GO:0042060","PTHR44329:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9829|UniProtKB=P04049","P06959; P00053; P00032; P00010; P00056; P00036; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00018; P00031; P00019"]
["c-Raf - phospho","Ser289/296/301","RAF1","74","rb",null,2,1,"n/a","n/a","n/a","n/a","# 2462",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TD., .TMAT., .TRASR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE","activation of adenylate cyclase activity; apoptotic process; cell differentiation; cellular glucose homeostasis; death-inducing signaling complex assembly; extrinsic apoptotic signaling pathway via death domain receptors; face development; insulin receptor signaling pathway; insulin secretion involved in cellular response to glucose stimulus; insulin-like growth factor receptor signaling pathway; intermediate filament cytoskeleton organization; MAPK cascade; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of protein-containing complex assembly; neurotrophin TRK receptor signaling pathway; phosphorylation; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein modification process; protein phosphorylation; regulation of apoptotic process; regulation of cell differentiation; regulation of cell motility; regulation of Rho protein signal transduction; response to muscle stretch; signal transduction; somatic stem cell population maintenance; thymus development; thyroid gland development; type B pancreatic cell proliferation; wound healing","ATP binding; enzyme binding; identical protein binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity","cytoplasm; cytosol; Golgi apparatus; membrane; mitochondrial outer membrane; mitochondrion; nucleus; plasma membrane; pseudopodium",null,"Raf-1 proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=5894","5894","110157","24703","484648",null,null,"P04049","Q99N57","P11345","A0A8I3PZA0","A0A287AZ70","A0A1D5QK38","GO:0005737; GO:0005829; GO:0005794; GO:0016020; GO:0005741; GO:0005739; GO:0005634; GO:0005886; GO:0031143","GO:0005524; GO:0019899; GO:0042802; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0043539; GO:0004674; GO:0031267; GO:0016740","GO:0007190; GO:0006915; GO:0030154; GO:0001678; GO:0071550; GO:0008625; GO:0060324; GO:0008286; GO:0035773; GO:0048009; GO:0045104; GO:0000165; GO:0043066; GO:0008285; GO:0043154; GO:1902042; GO:0031333; GO:0048011; GO:0016310; GO:0043410; GO:0033138; GO:0001934; GO:0045944; GO:0036211; GO:0006468; GO:0042981; GO:0045595; GO:2000145; GO:0035023; GO:0035994; GO:0007165; GO:0035019; GO:0048538; GO:0030878; GO:0044342; GO:0042060","PTHR44329:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9829|UniProtKB=P04049","P06959; P00053; P00032; P00010; P00056; P00036; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00018; P00031; P00019"]
["c-Raf - phospho","Ser338","RAF1","74","rb",null,2,4,4,4,4,4,"# 1219",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TD., .TMAT., .TRASR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE","activation of adenylate cyclase activity; apoptotic process; cell differentiation; cellular glucose homeostasis; death-inducing signaling complex assembly; extrinsic apoptotic signaling pathway via death domain receptors; face development; insulin receptor signaling pathway; insulin secretion involved in cellular response to glucose stimulus; insulin-like growth factor receptor signaling pathway; intermediate filament cytoskeleton organization; MAPK cascade; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of protein-containing complex assembly; neurotrophin TRK receptor signaling pathway; phosphorylation; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein modification process; protein phosphorylation; regulation of apoptotic process; regulation of cell differentiation; regulation of cell motility; regulation of Rho protein signal transduction; response to muscle stretch; signal transduction; somatic stem cell population maintenance; thymus development; thyroid gland development; type B pancreatic cell proliferation; wound healing","ATP binding; enzyme binding; identical protein binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity","cytoplasm; cytosol; Golgi apparatus; membrane; mitochondrial outer membrane; mitochondrion; nucleus; plasma membrane; pseudopodium","MAPK signaling","Raf-1 proto-oncogene, serine/threonine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=5894","5894","110157","24703","484648",null,null,"P04049","Q99N57","P11345","A0A8I3PZA0","A0A287AZ70","A0A1D5QK38","GO:0005737; GO:0005829; GO:0005794; GO:0016020; GO:0005741; GO:0005739; GO:0005634; GO:0005886; GO:0031143","GO:0005524; GO:0019899; GO:0042802; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0043539; GO:0004674; GO:0031267; GO:0016740","GO:0007190; GO:0006915; GO:0030154; GO:0001678; GO:0071550; GO:0008625; GO:0060324; GO:0008286; GO:0035773; GO:0048009; GO:0045104; GO:0000165; GO:0043066; GO:0008285; GO:0043154; GO:1902042; GO:0031333; GO:0048011; GO:0016310; GO:0043410; GO:0033138; GO:0001934; GO:0045944; GO:0036211; GO:0006468; GO:0042981; GO:0045595; GO:2000145; GO:0035023; GO:0035994; GO:0007165; GO:0035019; GO:0048538; GO:0030878; GO:0044342; GO:0042060","PTHR44329:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9829|UniProtKB=P04049","P06959; P00053; P00032; P00010; P00056; P00036; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00018; P00031; P00019"]
["CREB",null,"CREB1","43","rb",null,2,1,1,8.1,8,8,"# 1716",".AMPK., .APO., .cAMP., .CANCER., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DRAS., .DRR., .GPCR., .GPROT., .HEPB., .HUNT., .INS., .OP., .OPA., .OT., .P38., .PI3K., .PRC., .RTK., .SREME., .ST., .TNF., .TRASR.","CCKR signaling map; Transcription regulation by bZIP transcription factor; p38 MAPK pathway; Enkephalin release; Gonadotropin releasing hormone receptor pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Apoptosis signaling pathway","CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1","axonogenesis; cAMP-mediated signaling; cell differentiation; cellular response to forskolin; cellular response to growth factor stimulus; cellular response to hepatocyte growth factor stimulus; cellular response to leukemia inhibitory factor; cellular response to retinoic acid; cellular response to zinc ion; circadian rhythm; hormone secretion; lactation; lung epithelium development; lung saccule development; mammary gland development; memory; mRNA transcription by RNA polymerase II; negative regulation of transcription by competitive promoter binding; osteoclast differentiation; pituitary gland development; positive regulation of cardiac muscle tissue development; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; protein stabilization; regulation of cell size; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to glucagon; response to inorganic substance; response to organic substance; response to purine-containing compound; response to stimulus; response to xenobiotic stimulus; rhythmic process; secretory granule organization; signal transduction; type I pneumocyte differentiation","cAMP response element binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding","ATF4-CREB1 transcription factor complex; chromatin; euchromatin; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex","cAMP signaling / transcription factor","cAMP responsive element binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=1385","1385","12912","81646",null,null,null,"P16220","Q01147","P15337","A0A8I3PA22","A0A8W4FIL4","F6Z7F5","GO:1990589; GO:0000785; GO:0000791; GO:0005654; GO:0005634; GO:0090575; GO:0005667","GO:0035497; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0042802; GO:0005515; GO:0000978; GO:0000977; GO:0061629; GO:0043565; GO:1990837","GO:0007409; GO:0019933; GO:0030154; GO:1904322; GO:0071363; GO:0035729; GO:1990830; GO:0071300; GO:0071294; GO:0007623; GO:0046879; GO:0007595; GO:0060428; GO:0060430; GO:0030879; GO:0007613; GO:0042789; GO:0010944; GO:0030316; GO:0021983; GO:0055025; GO:0045893; GO:0045600; GO:0046887; GO:0046889; GO:0040018; GO:0045672; GO:0045944; GO:0006468; GO:0050821; GO:0008361; GO:0006355; GO:0006357; GO:0033762; GO:0010035; GO:0010033; GO:0014074; GO:0050896; GO:0009410; GO:0048511; GO:0033363; GO:0007165; GO:0060509","PTHR45879:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2345|UniProtKB=P16220","P06959; P00055; P05918; P05913; P06664; P00026; P00006"]
["CREB - phospho","Ser133","CREB1","43","rb",null,2,2,8,8,8,7,"# 1920",".AMPK., .APO., .cAMP., .CANCER., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DRAS., .DRR., .GPCR., .GPROT., .HEPB., .HUNT., .INS., .OP., .OPA., .OT., .P38., .PI3K., .PRC., .RTK., .SREME., .ST., .TNF., .TRASR.","CCKR signaling map; Transcription regulation by bZIP transcription factor; p38 MAPK pathway; Enkephalin release; Gonadotropin releasing hormone receptor pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Apoptosis signaling pathway","CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1","axonogenesis; cAMP-mediated signaling; cell differentiation; cellular response to forskolin; cellular response to growth factor stimulus; cellular response to hepatocyte growth factor stimulus; cellular response to leukemia inhibitory factor; cellular response to retinoic acid; cellular response to zinc ion; circadian rhythm; hormone secretion; lactation; lung epithelium development; lung saccule development; mammary gland development; memory; mRNA transcription by RNA polymerase II; negative regulation of transcription by competitive promoter binding; osteoclast differentiation; pituitary gland development; positive regulation of cardiac muscle tissue development; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; protein stabilization; regulation of cell size; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to glucagon; response to inorganic substance; response to organic substance; response to purine-containing compound; response to stimulus; response to xenobiotic stimulus; rhythmic process; secretory granule organization; signal transduction; type I pneumocyte differentiation","cAMP response element binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding","ATF4-CREB1 transcription factor complex; chromatin; euchromatin; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex","cAMP signaling / transcription factor","cAMP responsive element binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=1385","1385","12912","81646",null,null,null,"P16220","Q01147","P15337","A0A8I3PA22","A0A8W4FIL4","F6Z7F5","GO:1990589; GO:0000785; GO:0000791; GO:0005654; GO:0005634; GO:0090575; GO:0005667","GO:0035497; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0042802; GO:0005515; GO:0000978; GO:0000977; GO:0061629; GO:0043565; GO:1990837","GO:0007409; GO:0019933; GO:0030154; GO:1904322; GO:0071363; GO:0035729; GO:1990830; GO:0071300; GO:0071294; GO:0007623; GO:0046879; GO:0007595; GO:0060428; GO:0060430; GO:0030879; GO:0007613; GO:0042789; GO:0010944; GO:0030316; GO:0021983; GO:0055025; GO:0045893; GO:0045600; GO:0046887; GO:0046889; GO:0040018; GO:0045672; GO:0045944; GO:0006468; GO:0050821; GO:0008361; GO:0006355; GO:0006357; GO:0033762; GO:0010035; GO:0010033; GO:0014074; GO:0050896; GO:0009410; GO:0048511; GO:0033363; GO:0007165; GO:0060509","PTHR45879:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2345|UniProtKB=P16220","P06959; P00055; P05918; P05913; P06664; P00026; P00006"]
["Crk (p38)",null,"CRK","38","rb",null,1.1000000000000001,1.1000000000000001,8,1,8,8,"# 0235",".ANG., .CANCER., .CANPTHW., .CCKR., .CCP., .CML., .CP., .CSP., .EGFR., .IMUR., .INS., .INT., .JNK., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RAS., .RCC., .RTK., .SREME., .ST., .TRASR.","CCKR signaling map; Integrin signalling pathway; Angiogenesis","ADAPTER MOLECULE CRK","actin cytoskeleton organization; activation of GTPase activity; cell chemotaxis; cell migration; cell population proliferation; cellular response to endothelin; cellular response to insulin-like growth factor stimulus; cellular response to nerve growth factor stimulus; cellular response to nitric oxide; cellular response to transforming growth factor beta stimulus; cerebellar neuron development; cerebral cortex development; dendrite development; ephrin receptor signaling pathway; establishment of cell polarity; helper T cell diapedesis; hippocampus development; lipid metabolic process; negative regulation of cell motility; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of wound healing; neuron migration; positive regulation of JNK cascade; positive regulation of smooth muscle cell migration; positive regulation of substrate adhesion-dependent cell spreading; postsynaptic specialization assembly; protein localization to membrane; reelin-mediated signaling pathway; regulation of actin cytoskeleton organization; regulation of cell adhesion mediated by integrin; regulation of cell shape; regulation of dendrite development; regulation of GTPase activity; regulation of intracellular signal transduction; regulation of leukocyte migration; regulation of protein binding; regulation of Rac protein signal transduction; regulation of signal transduction; regulation of T cell migration; regulation of transcription by RNA polymerase II; response to cholecystokinin; response to hepatocyte growth factor; response to hydrogen peroxide; response to peptide; response to yeast; signal transduction","cytoskeletal protein binding; enzyme binding; ephrin receptor binding; insulin-like growth factor receptor binding; kinase binding; molecular adaptor activity; phosphotyrosine residue binding; protein binding; protein domain specific binding; protein phosphorylated amino acid binding; protein self-association; protein tyrosine kinase binding; protein-macromolecule adaptor activity; receptor tyrosine kinase binding; scaffold protein binding; SH2 domain binding; SH3 domain binding; signaling adaptor activity; signaling receptor complex adaptor activity; ubiquitin protein ligase binding","actin cytoskeleton; cytoplasm; cytosol; extracellular exosome; membrane; membrane raft; neuromuscular junction; nucleus; plasma membrane; protein-containing complex","MAPK signaling","CRK proto-oncogene, adaptor protein","http://www.ncbi.nlm.nih.gov/gene/?term=1398","1398","12928","54245",null,null,"701185","P46108","Q64010","Q63768","A0A8P0PH15",null,"H9FQ57","GO:0015629; GO:0005737; GO:0005829; GO:0070062; GO:0016020; GO:0045121; GO:0031594; GO:0005634; GO:0005886; GO:0032991","GO:0008092; GO:0019899; GO:0046875; GO:0005159; GO:0019900; GO:0060090; GO:0001784; GO:0005515; GO:0019904; GO:0045309; GO:0043621; GO:1990782; GO:0030674; GO:0030971; GO:0097110; GO:0042169; GO:0017124; GO:0035591; GO:0030159; GO:0031625","GO:0030036; GO:0090630; GO:0060326; GO:0016477; GO:0008283; GO:1990859; GO:1990314; GO:1990090; GO:0071732; GO:0071560; GO:0098749; GO:0021987; GO:0016358; GO:0048013; GO:0030010; GO:0035685; GO:0021766; GO:0006629; GO:2000146; GO:0045953; GO:0061045; GO:0001764; GO:0046330; GO:0014911; GO:1900026; GO:0098698; GO:0072657; GO:0038026; GO:0032956; GO:0033628; GO:0008360; GO:0050773; GO:0043087; GO:1902531; GO:0002685; GO:0043393; GO:0035020; GO:0009966; GO:2000404; GO:0006357; GO:0061847; GO:0035728; GO:0042542; GO:1901652; GO:0001878; GO:0007165","PTHR19969:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2362|UniProtKB=P46108","P06959; P00034; P00005"]
["Crk (p38) - phospho","Tyr221","CRK","38","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0225",".ANG., .CANCER., .CANPTHW., .CCKR., .CCP., .CML., .CP., .CSP., .EGFR., .IMUR., .INS., .INT., .JNK., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RAS., .RCC., .RTK., .SREME., .ST., .TRASR.","CCKR signaling map; Integrin signalling pathway; Angiogenesis","ADAPTER MOLECULE CRK","actin cytoskeleton organization; activation of GTPase activity; cell chemotaxis; cell migration; cell population proliferation; cellular response to endothelin; cellular response to insulin-like growth factor stimulus; cellular response to nerve growth factor stimulus; cellular response to nitric oxide; cellular response to transforming growth factor beta stimulus; cerebellar neuron development; cerebral cortex development; dendrite development; ephrin receptor signaling pathway; establishment of cell polarity; helper T cell diapedesis; hippocampus development; lipid metabolic process; negative regulation of cell motility; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of wound healing; neuron migration; positive regulation of JNK cascade; positive regulation of smooth muscle cell migration; positive regulation of substrate adhesion-dependent cell spreading; postsynaptic specialization assembly; protein localization to membrane; reelin-mediated signaling pathway; regulation of actin cytoskeleton organization; regulation of cell adhesion mediated by integrin; regulation of cell shape; regulation of dendrite development; regulation of GTPase activity; regulation of intracellular signal transduction; regulation of leukocyte migration; regulation of protein binding; regulation of Rac protein signal transduction; regulation of signal transduction; regulation of T cell migration; regulation of transcription by RNA polymerase II; response to cholecystokinin; response to hepatocyte growth factor; response to hydrogen peroxide; response to peptide; response to yeast; signal transduction","cytoskeletal protein binding; enzyme binding; ephrin receptor binding; insulin-like growth factor receptor binding; kinase binding; molecular adaptor activity; phosphotyrosine residue binding; protein binding; protein domain specific binding; protein phosphorylated amino acid binding; protein self-association; protein tyrosine kinase binding; protein-macromolecule adaptor activity; receptor tyrosine kinase binding; scaffold protein binding; SH2 domain binding; SH3 domain binding; signaling adaptor activity; signaling receptor complex adaptor activity; ubiquitin protein ligase binding","actin cytoskeleton; cytoplasm; cytosol; extracellular exosome; membrane; membrane raft; neuromuscular junction; nucleus; plasma membrane; protein-containing complex","MAPK signaling","CRK proto-oncogene, adaptor protein","http://www.ncbi.nlm.nih.gov/gene/?term=1398","1398","12928","54245",null,null,"701185","P46108","Q64010","Q63768","A0A8P0PH15",null,"H9FQ57","GO:0015629; GO:0005737; GO:0005829; GO:0070062; GO:0016020; GO:0045121; GO:0031594; GO:0005634; GO:0005886; GO:0032991","GO:0008092; GO:0019899; GO:0046875; GO:0005159; GO:0019900; GO:0060090; GO:0001784; GO:0005515; GO:0019904; GO:0045309; GO:0043621; GO:1990782; GO:0030674; GO:0030971; GO:0097110; GO:0042169; GO:0017124; GO:0035591; GO:0030159; GO:0031625","GO:0030036; GO:0090630; GO:0060326; GO:0016477; GO:0008283; GO:1990859; GO:1990314; GO:1990090; GO:0071732; GO:0071560; GO:0098749; GO:0021987; GO:0016358; GO:0048013; GO:0030010; GO:0035685; GO:0021766; GO:0006629; GO:2000146; GO:0045953; GO:0061045; GO:0001764; GO:0046330; GO:0014911; GO:1900026; GO:0098698; GO:0072657; GO:0038026; GO:0032956; GO:0033628; GO:0008360; GO:0050773; GO:0043087; GO:1902531; GO:0002685; GO:0043393; GO:0035020; GO:0009966; GO:2000404; GO:0006357; GO:0061847; GO:0035728; GO:0042542; GO:1901652; GO:0001878; GO:0007165","PTHR19969:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2362|UniProtKB=P46108","P06959; P00034; P00005"]
["CRP1",null,"CRIP1","23","ms",null,2,1,1,8,1,1,"# 0512",".APO., .CD., .CSP., .DDR., .IMU., .IMUR., .OP., .OT., .TRASR.",null,"CYSTEINE-RICH PROTEIN 1","cellular response to antibiotic; cellular response to UV-B; heart development; immune response; intrinsic apoptotic signaling pathway in response to DNA damage; prostate gland stromal morphogenesis; regulation of gene expression; response to organic substance; response to zinc ion","metal ion binding; peptide binding; zinc ion binding","cytoplasm","Zinc transport","cysteine rich protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=1396","1396","12925","691657","612713",null,null,"P50238","P63254","P63255","A0A8I3PT20",null,null,"GO:0005737","GO:0046872; GO:0042277; GO:0008270","GO:0071236; GO:0071493; GO:0007507; GO:0006955; GO:0008630; GO:0060741; GO:0010468; GO:0010033; GO:0010043","PTHR46074:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2360|UniProtKB=P50238"]
["CTGF",null,"CCN2","36","rb",null,2,2,8,1,6,6,"# 1420",".ANG., .CANCER., .CCP., .CP., .CSP., .DEV., .FGFR., .HIPPO., .INT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR.",null,"CCN FAMILY MEMBER 2","aging; angiogenesis; calcium ion transmembrane import into cytosol; cartilage condensation; cell adhesion; cell migration; cell-matrix adhesion; chondrocyte differentiation; chondrocyte proliferation; connective tissue development; DNA biosynthetic process; epidermis development; extracellular matrix constituent secretion; fibroblast growth factor receptor signaling pathway; integrin-mediated signaling pathway; intracellular signal transduction; lung development; negative regulation of cell death; negative regulation of gene expression; ossification; positive regulation of cardiac muscle contraction; positive regulation of cell activation; positive regulation of cell death; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of collagen biosynthetic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of G0 to G1 transition; positive regulation of gene expression; positive regulation of JNK cascade; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; reactive oxygen species metabolic process; regulation of chondrocyte differentiation; regulation of developmental process; response to amino acid; response to anoxia; response to estradiol; response to fatty acid; response to glucose; response to mineralocorticoid; response to organic cyclic compound; response to peptide hormone; response to wounding; signal transduction; tissue homeostasis","fibronectin binding; growth factor activity; heparin binding; insulin-like growth factor binding; integrin binding; protein binding; protein C-terminus binding","cell cortex; cis-Golgi network; collagen-containing extracellular matrix; cytosol; extracellular matrix; extracellular region; extracellular space; perinuclear region of cytoplasm; plasma membrane","Cell adhesion","cellular communication network factor 2","http://www.ncbi.nlm.nih.gov/gene/?term=1490","1490","14219",null,"476202",null,"714520","P29279","P29268","A0A8L2UJK5","A0A8I3MT25","A0A287A0A9","H9FQD5","GO:0005938; GO:0005801; GO:0062023; GO:0005829; GO:0031012; GO:0005576; GO:0005615; GO:0048471; GO:0005886","GO:0001968; GO:0008083; GO:0008201; GO:0005520; GO:0005178; GO:0005515; GO:0008022","GO:0007568; GO:0001525; GO:0097553; GO:0001502; GO:0007155; GO:0016477; GO:0007160; GO:0002062; GO:0035988; GO:0061448; GO:0071897; GO:0008544; GO:0070278; GO:0008543; GO:0007229; GO:0035556; GO:0030324; GO:0060548; GO:0010629; GO:0001503; GO:0060452; GO:0050867; GO:0010942; GO:0045597; GO:0008284; GO:0032967; GO:0043280; GO:0070374; GO:0070318; GO:0010628; GO:0046330; GO:0001934; GO:0051496; GO:0072593; GO:0032330; GO:0050793; GO:0043200; GO:0034059; GO:0032355; GO:0070542; GO:0009749; GO:0051385; GO:0014070; GO:0043434; GO:0009611; GO:0007165; GO:0001894","PTHR11348:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2500|UniProtKB=P29279"]
["CTR1 (SLC31A1)",null,"SLC31A1","34-26","rb",null,2,2.1,2.1,2.1,2,2,"# 1466",null,null,"HIGH AFFINITY COPPER UPTAKE PROTEIN 1","cellular copper ion homeostasis; copper ion import; copper ion transmembrane transport; copper ion transport; establishment of localization in cell; ion transport","copper ion transmembrane transporter activity; identical protein binding","intercalated disc; late endosome; membrane; plasma membrane; recycling endosome","Metabolism","solute carrier family 31 member 1","http://www.ncbi.nlm.nih.gov/gene/?term=1317","1317","20529",null,null,null,"706058","O15431","Q8K211","A0A8I6AQ78","A0A8I3N3B2",null,"F6USX2","GO:0014704; GO:0005770; GO:0016020; GO:0005886; GO:0055037","GO:0005375; GO:0042802","GO:0006878; GO:0015677; GO:0035434; GO:0006825; GO:0051649; GO:0006811","PTHR12483:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11016|UniProtKB=O15431"]
["Cyclin A1",null,"CCNA1","48","ms",null,4,4,"n/a","n/a","n/a","n/a","# 3082",".AML., .AMPK., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DI., .HEPB., .OP., .P53S., .SREME.","p53 pathway feedback loops 2","CYCLIN-A1","cell cycle; cell division; male meiosis I; mitotic cell cycle phase transition; regulation of cyclin-dependent protein serine/threonine kinase activity; spermatogenesis","cyclin-dependent protein serine/threonine kinase regulator activity; protein binding","cyclin A1-CDK2 complex; cyclin A2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; microtubule cytoskeleton; nucleoplasm; nucleus","Cell cycle control","cyclin A1","http://www.ncbi.nlm.nih.gov/gene/?term=8900","8900","12427","295052",null,null,"693797","P78396","Q61456","Q6AY13","A0A8I3Q3S2","A0A286ZUS6","F6RGI5","GO:0097123; GO:0097124; GO:0000307; GO:0005737; GO:0005829; GO:0015630; GO:0005654; GO:0005634","GO:0016538; GO:0005515","GO:0007049; GO:0051301; GO:0007141; GO:0044772; GO:0000079; GO:0007283","PTHR10177:SF254","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1577|UniProtKB=P78396","P04398"]
["Cyclin A1",null,"CCNA1","49","rb",null,2,2,6,6,2,2,"TK # 103",".AML., .AMPK., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DI., .HEPB., .OP., .P53S., .SREME.","p53 pathway feedback loops 2","CYCLIN-A1","cell cycle; cell division; male meiosis I; mitotic cell cycle phase transition; regulation of cyclin-dependent protein serine/threonine kinase activity; spermatogenesis","cyclin-dependent protein serine/threonine kinase regulator activity; protein binding","cyclin A1-CDK2 complex; cyclin A2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; microtubule cytoskeleton; nucleoplasm; nucleus","Cell cycle control","cyclin A1","http://www.ncbi.nlm.nih.gov/gene/?term=8900","8900","12427","295052",null,null,"693797","P78396","Q61456","Q6AY13","A0A8I3Q3S2","A0A286ZUS6","F6RGI5","GO:0097123; GO:0097124; GO:0000307; GO:0005737; GO:0005829; GO:0015630; GO:0005654; GO:0005634","GO:0016538; GO:0005515","GO:0007049; GO:0051301; GO:0007141; GO:0044772; GO:0000079; GO:0007283","PTHR10177:SF254","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1577|UniProtKB=P78396","P04398"]
["Cyclin A2",null,"CCNA2","50","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0237",".AML., .AMPK., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DI., .HEPB., .HIF., .OP., .OT., .P53S., .RAS., .RTK., .SREME., .TRASR.","p53 pathway feedback loops 2","CYCLIN-A2","animal organ regeneration; cell cycle; cell cycle G1/S phase transition; cell division; cellular response to cocaine; cellular response to estradiol stimulus; cellular response to hypoxia; cellular response to insulin-like growth factor stimulus; cellular response to leptin stimulus; cellular response to luteinizing hormone stimulus; cellular response to nitric oxide; cellular response to organic cyclic compound; cellular response to platelet-derived growth factor stimulus; cochlea development; DNA-templated transcription; G2/M transition of mitotic cell cycle; mitotic cell cycle phase transition; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; post-translational protein modification; Ras protein signal transduction; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA replication; response to estradiol; response to glucagon","cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein domain specific binding; protein kinase binding","cyclin A2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; female pronucleus; male pronucleus; nucleoplasm; nucleus","Cell cycle control","cyclin A2","http://www.ncbi.nlm.nih.gov/gene/?term=890","890","12428","114494","483845",null,"707259","P20248","P51943","A0A0G2JVY9","A0A8I3PCC0",null,"F6WZV1","GO:0097124; GO:0000307; GO:0005737; GO:0005829; GO:0001939; GO:0001940; GO:0005654; GO:0005634","GO:0016538; GO:0005515; GO:0019904; GO:0019901","GO:0031100; GO:0007049; GO:0044843; GO:0051301; GO:0071314; GO:0071392; GO:0071456; GO:1990314; GO:0044320; GO:0071373; GO:0071732; GO:0071407; GO:0036120; GO:0090102; GO:0006351; GO:0000086; GO:0044772; GO:0045893; GO:0048146; GO:0043687; GO:0007265; GO:0000079; GO:0006275; GO:0032355; GO:0033762","PTHR10177:SF444","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1578|UniProtKB=P20248","P04398"]
["Cyclin B1",null,"CCNB1","58","rb",null,2,4,4,4,4,4,"# 2557",".CCP., .CCY., .CD., .CP., .CSP., .FOXO., .OP., .OPA., .P53S., .ST.","p53 pathway; Cell cycle","G2/MITOTIC-SPECIFIC CYCLIN-B1","cell cycle; cell division; G2/M transition of mitotic cell cycle; in utero embryonic development; mitotic cell cycle phase transition; mitotic metaphase plate congression; mitotic spindle organization; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of cell cycle; positive regulation of fibroblast proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; protein phosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic cell cycle spindle assembly checkpoint","cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase regulator activity; molecular adaptor activity; patched binding; protein binding; protein kinase binding; ubiquitin-like protein ligase binding","centrosome; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; membrane; microtubule organizing center; mitochondrial matrix; nucleoplasm; nucleus; outer kinetochore; spindle pole","Cell cycle control","cyclin B1","http://www.ncbi.nlm.nih.gov/gene/?term=891","891","268697","25203",null,"397662",null,"P14635","P24860","P30277","A0A8P0SW93","D2IE28","F7F783","GO:0005813; GO:0097125; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0016020; GO:0005815; GO:0005759; GO:0005654; GO:0005634; GO:0000940; GO:0000922","GO:0061575; GO:0016538; GO:0060090; GO:0005113; GO:0005515; GO:0019901; GO:0044389","GO:0007049; GO:0051301; GO:0000086; GO:0001701; GO:0044772; GO:0007080; GO:0007052; GO:0051987; GO:0045787; GO:0048146; GO:0010971; GO:1905448; GO:0045931; GO:0006468; GO:0000079; GO:0090266","PTHR10177:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1579|UniProtKB=P14635","P00059; P00013"]
["Cyclin B1 - phospho","Ser133","CCNB1","58","rb",null,1.1000000000000001,4,4,4,8,8,"# 2851",".CCP., .CCY., .CD., .CP., .CSP., .FOXO., .OP., .OPA., .P53S., .ST.","p53 pathway; Cell cycle","G2/MITOTIC-SPECIFIC CYCLIN-B1","cell cycle; cell division; G2/M transition of mitotic cell cycle; in utero embryonic development; mitotic cell cycle phase transition; mitotic metaphase plate congression; mitotic spindle organization; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of cell cycle; positive regulation of fibroblast proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; protein phosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic cell cycle spindle assembly checkpoint","cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase regulator activity; molecular adaptor activity; patched binding; protein binding; protein kinase binding; ubiquitin-like protein ligase binding","centrosome; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; membrane; microtubule organizing center; mitochondrial matrix; nucleoplasm; nucleus; outer kinetochore; spindle pole","Cell cycle control","cyclin B1","http://www.ncbi.nlm.nih.gov/gene/?term=891","891","268697","25203",null,"397662",null,"P14635","P24860","P30277","A0A8P0SW93","D2IE28","F7F783","GO:0005813; GO:0097125; GO:0000307; GO:0005737; GO:0005856; GO:0005829; GO:0016020; GO:0005815; GO:0005759; GO:0005654; GO:0005634; GO:0000940; GO:0000922","GO:0061575; GO:0016538; GO:0060090; GO:0005113; GO:0005515; GO:0019901; GO:0044389","GO:0007049; GO:0051301; GO:0000086; GO:0001701; GO:0044772; GO:0007080; GO:0007052; GO:0051987; GO:0045787; GO:0048146; GO:0010971; GO:1905448; GO:0045931; GO:0006468; GO:0000079; GO:0090266","PTHR10177:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1579|UniProtKB=P14635","P00059; P00013"]
["Cyclin D1",null,"CCND1","36","ms",null,2,2,6,2,5,5,"# 1067",".AML., .AMPK., .APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DRR., .EMC., .FOXO., .GLI., .HHSP., .HIPPO., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR., .WNT.","CCKR signaling map; Cell cycle; PI3 kinase pathway; Wnt signaling pathway","G1/S-SPECIFIC CYCLIN-D1","animal organ regeneration; cell cycle; cell division; cell population proliferation; cellular response to DNA damage stimulus; cellular response to organic substance; endoplasmic reticulum unfolded protein response; fat cell differentiation; G1/S transition of mitotic cell cycle; lactation; Leydig cell differentiation; liver development; liver regeneration; mammary gland alveolus development; mammary gland epithelial cell proliferation; mitotic cell cycle phase transition; mitotic G1 DNA damage checkpoint signaling; negative regulation of epithelial cell differentiation; negative regulation of neuron apoptotic process; negative regulation of transcription by RNA polymerase II; neuron differentiation; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein phosphorylation; protein phosphorylation; re-entry into mitotic cell cycle; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of G1/S transition of mitotic cell cycle; response to calcium ion; response to corticosterone; response to estradiol; response to estrogen; response to ethanol; response to glucocorticoid; response to iron ion; response to leptin; response to magnesium ion; response to organic cyclic compound; response to organic substance; response to organonitrogen compound; response to steroid hormone; response to UV-A; response to vitamin E; response to xenobiotic stimulus; response to X-ray; Wnt signaling pathway","cyclin-dependent protein serine/threonine kinase regulator activity; enzyme binding; histone deacetylase binding; kinase activity; proline-rich region binding; protein binding; protein kinase activity; protein kinase binding; protein-containing complex binding; transcription corepressor activity","bicellular tight junction; cyclin D1-CDK4 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; membrane; nuclear membrane; nucleoplasm; nucleus; transcription repressor complex","Cell cycle control","cyclin D1","http://www.ncbi.nlm.nih.gov/gene/?term=595","595","12443","58919",null,null,null,"P24385","P25322","P39948","A0A8P0TDV9",null,"A0A1D5QW81","GO:0005923; GO:0097128; GO:0000307; GO:0005737; GO:0005829; GO:0016020; GO:0031965; GO:0005654; GO:0005634; GO:0017053","GO:0016538; GO:0019899; GO:0042826; GO:0016301; GO:0070064; GO:0005515; GO:0004672; GO:0019901; GO:0044877; GO:0003714","GO:0031100; GO:0007049; GO:0051301; GO:0008283; GO:0006974; GO:0071310; GO:0030968; GO:0045444; GO:0000082; GO:0007595; GO:0033327; GO:0001889; GO:0097421; GO:0060749; GO:0033598; GO:0044772; GO:0031571; GO:0030857; GO:0043524; GO:0000122; GO:0030182; GO:0008284; GO:0045737; GO:1900087; GO:0010971; GO:0033601; GO:0001934; GO:0006468; GO:0000320; GO:0051726; GO:0000079; GO:2000045; GO:0051592; GO:0051412; GO:0032355; GO:0043627; GO:0045471; GO:0051384; GO:0010039; GO:0044321; GO:0032026; GO:0014070; GO:0010033; GO:0010243; GO:0048545; GO:0070141; GO:0033197; GO:0009410; GO:0010165; GO:0016055","PTHR10177:SF67","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1582|UniProtKB=P24385","P06959; P00013; P00048; P00057"]
["Cyclin D1",null,"CCND1","36","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2463",".AML., .AMPK., .APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .DRR., .EMC., .FOXO., .GLI., .HHSP., .HIPPO., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR., .WNT.","CCKR signaling map; Cell cycle; PI3 kinase pathway; Wnt signaling pathway","G1/S-SPECIFIC CYCLIN-D1","animal organ regeneration; cell cycle; cell division; cell population proliferation; cellular response to DNA damage stimulus; cellular response to organic substance; endoplasmic reticulum unfolded protein response; fat cell differentiation; G1/S transition of mitotic cell cycle; lactation; Leydig cell differentiation; liver development; liver regeneration; mammary gland alveolus development; mammary gland epithelial cell proliferation; mitotic cell cycle phase transition; mitotic G1 DNA damage checkpoint signaling; negative regulation of epithelial cell differentiation; negative regulation of neuron apoptotic process; negative regulation of transcription by RNA polymerase II; neuron differentiation; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein phosphorylation; protein phosphorylation; re-entry into mitotic cell cycle; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of G1/S transition of mitotic cell cycle; response to calcium ion; response to corticosterone; response to estradiol; response to estrogen; response to ethanol; response to glucocorticoid; response to iron ion; response to leptin; response to magnesium ion; response to organic cyclic compound; response to organic substance; response to organonitrogen compound; response to steroid hormone; response to UV-A; response to vitamin E; response to xenobiotic stimulus; response to X-ray; Wnt signaling pathway","cyclin-dependent protein serine/threonine kinase regulator activity; enzyme binding; histone deacetylase binding; kinase activity; proline-rich region binding; protein binding; protein kinase activity; protein kinase binding; protein-containing complex binding; transcription corepressor activity","bicellular tight junction; cyclin D1-CDK4 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; membrane; nuclear membrane; nucleoplasm; nucleus; transcription repressor complex","Cell cycle control","cyclin D1","http://www.ncbi.nlm.nih.gov/gene/?term=595","595","12443","58919",null,null,null,"P24385","P25322","P39948","A0A8P0TDV9",null,"A0A1D5QW81","GO:0005923; GO:0097128; GO:0000307; GO:0005737; GO:0005829; GO:0016020; GO:0031965; GO:0005654; GO:0005634; GO:0017053","GO:0016538; GO:0019899; GO:0042826; GO:0016301; GO:0070064; GO:0005515; GO:0004672; GO:0019901; GO:0044877; GO:0003714","GO:0031100; GO:0007049; GO:0051301; GO:0008283; GO:0006974; GO:0071310; GO:0030968; GO:0045444; GO:0000082; GO:0007595; GO:0033327; GO:0001889; GO:0097421; GO:0060749; GO:0033598; GO:0044772; GO:0031571; GO:0030857; GO:0043524; GO:0000122; GO:0030182; GO:0008284; GO:0045737; GO:1900087; GO:0010971; GO:0033601; GO:0001934; GO:0006468; GO:0000320; GO:0051726; GO:0000079; GO:2000045; GO:0051592; GO:0051412; GO:0032355; GO:0043627; GO:0045471; GO:0051384; GO:0010039; GO:0044321; GO:0032026; GO:0014070; GO:0010033; GO:0010243; GO:0048545; GO:0070141; GO:0033197; GO:0009410; GO:0010165; GO:0016055","PTHR10177:SF67","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1582|UniProtKB=P24385","P06959; P00013; P00048; P00057"]
["Cyclin D1 - phospho","Thr286","CCND1","33","rb",null,3,2,"n/a","n/a","n/a","n/a","# 2399",".AML., .AMPK., .APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .DRR., .EMC., .FOXO., .GLI., .HHSP., .HIPPO., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR., .WNT.","CCKR signaling map; Cell cycle; PI3 kinase pathway; Wnt signaling pathway","G1/S-SPECIFIC CYCLIN-D1","animal organ regeneration; cell cycle; cell division; cell population proliferation; cellular response to DNA damage stimulus; cellular response to organic substance; endoplasmic reticulum unfolded protein response; fat cell differentiation; G1/S transition of mitotic cell cycle; lactation; Leydig cell differentiation; liver development; liver regeneration; mammary gland alveolus development; mammary gland epithelial cell proliferation; mitotic cell cycle phase transition; mitotic G1 DNA damage checkpoint signaling; negative regulation of epithelial cell differentiation; negative regulation of neuron apoptotic process; negative regulation of transcription by RNA polymerase II; neuron differentiation; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein phosphorylation; protein phosphorylation; re-entry into mitotic cell cycle; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of G1/S transition of mitotic cell cycle; response to calcium ion; response to corticosterone; response to estradiol; response to estrogen; response to ethanol; response to glucocorticoid; response to iron ion; response to leptin; response to magnesium ion; response to organic cyclic compound; response to organic substance; response to organonitrogen compound; response to steroid hormone; response to UV-A; response to vitamin E; response to xenobiotic stimulus; response to X-ray; Wnt signaling pathway","cyclin-dependent protein serine/threonine kinase regulator activity; enzyme binding; histone deacetylase binding; kinase activity; proline-rich region binding; protein binding; protein kinase activity; protein kinase binding; protein-containing complex binding; transcription corepressor activity","bicellular tight junction; cyclin D1-CDK4 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; membrane; nuclear membrane; nucleoplasm; nucleus; transcription repressor complex",null,"cyclin D1","http://www.ncbi.nlm.nih.gov/gene/?term=595","595","12443","58919",null,null,null,"P24385","P25322","P39948","A0A8P0TDV9",null,"A0A1D5QW81","GO:0005923; GO:0097128; GO:0000307; GO:0005737; GO:0005829; GO:0016020; GO:0031965; GO:0005654; GO:0005634; GO:0017053","GO:0016538; GO:0019899; GO:0042826; GO:0016301; GO:0070064; GO:0005515; GO:0004672; GO:0019901; GO:0044877; GO:0003714","GO:0031100; GO:0007049; GO:0051301; GO:0008283; GO:0006974; GO:0071310; GO:0030968; GO:0045444; GO:0000082; GO:0007595; GO:0033327; GO:0001889; GO:0097421; GO:0060749; GO:0033598; GO:0044772; GO:0031571; GO:0030857; GO:0043524; GO:0000122; GO:0030182; GO:0008284; GO:0045737; GO:1900087; GO:0010971; GO:0033601; GO:0001934; GO:0006468; GO:0000320; GO:0051726; GO:0000079; GO:2000045; GO:0051592; GO:0051412; GO:0032355; GO:0043627; GO:0045471; GO:0051384; GO:0010039; GO:0044321; GO:0032026; GO:0014070; GO:0010033; GO:0010243; GO:0048545; GO:0070141; GO:0033197; GO:0009410; GO:0010165; GO:0016055","PTHR10177:SF67","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1582|UniProtKB=P24385","P06959; P00013; P00048; P00057"]
["Cyclin D2",null,"CCND2","31","rb",null,1,2,6,6,8,8,"# 2165",".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .FOXO., .HHSP., .HIPPO., .OP., .OPA., .P53S., .PI3K., .RTK., .ST., .STAT., .WNT.","Cell cycle; PI3 kinase pathway","G1/S-SPECIFIC CYCLIN-D2","adult locomotory behavior; cell cycle; cell division; cellular response to X-ray; G1/S transition of mitotic cell cycle; long-term memory; mitotic cell cycle phase transition; negative regulation of apoptotic process; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of protein phosphorylation; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity","cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein kinase binding","chromatin; cyclin D2-CDK4 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; membrane; nuclear membrane; nucleolus; nucleoplasm; nucleus","Cell cycle control","cyclin D2","http://www.ncbi.nlm.nih.gov/gene/?term=894","894","12444",null,null,null,null,"P30279","P30280",null,"A0A8I3Q7A5",null,"A0A5F7ZGN1","GO:0000785; GO:0097129; GO:0000307; GO:0005737; GO:0005829; GO:0016020; GO:0031965; GO:0005730; GO:0005654; GO:0005634","GO:0016538; GO:0005515; GO:0019901","GO:0008344; GO:0007049; GO:0051301; GO:0071481; GO:0000082; GO:0007616; GO:0044772; GO:0043066; GO:0008284; GO:0045737; GO:1900087; GO:0001934; GO:0051726; GO:0000079","PTHR10177:SF66","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1583|UniProtKB=P30279","P00013; P00048"]
["Cyclin E1",null,"CCNE1","48","ms",null,2,2,2,8,8,8,"# 2120",".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .HEPB., .OP., .OPA., .OT., .P53S., .PARK., .PI3K., .PRC., .RTK., .SCLC., .ST., .TRASR., .WNT.","p53 pathway; Parkinson disease; Cell cycle; p53 pathway feedback loops 2","G1/S-SPECIFIC CYCLIN-E1","cell cycle; cell division; chromosome organization involved in meiotic cell cycle; DNA replication initiation; G1/S transition of mitotic cell cycle; homologous chromosome pairing at meiosis; mitotic cell cycle phase transition; negative regulation of transcription by RNA polymerase II; positive regulation of mesenchymal stem cell proliferation; protein phosphorylation; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of protein localization; telomere maintenance; Wnt signaling pathway","cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; protein binding; protein kinase binding","centrosome; cyclin E1-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; nucleoplasm; nucleus","Cell cycle control","cyclin E1","http://www.ncbi.nlm.nih.gov/gene/?term=898","898","12447","25729",null,null,null,"P24864","Q61457","B1WC54","A0A8I3MDI8","A0A5G2RGD8","A0A1D5QCQ1","GO:0005813; GO:0097134; GO:0000307; GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0016538; GO:0016301; GO:0005515; GO:0019901","GO:0007049; GO:0051301; GO:0070192; GO:0006270; GO:0000082; GO:0007129; GO:0044772; GO:0000122; GO:1902462; GO:0006468; GO:0051726; GO:0000079; GO:0032880; GO:0000723; GO:0016055","PTHR10177:SF71","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1589|UniProtKB=P24864","P00059; P00049; P00013; P04398"]
["Cyclin E1 - phospho","Thr62","CCNE1","48","rb",null,2.1,4,4,4,4,4,"# 1512",".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .HEPB., .OP., .OPA., .OT., .P53S., .PARK., .PI3K., .PRC., .RTK., .SCLC., .ST., .TRASR., .WNT.","p53 pathway; Parkinson disease; Cell cycle; p53 pathway feedback loops 2","G1/S-SPECIFIC CYCLIN-E1","cell cycle; cell division; chromosome organization involved in meiotic cell cycle; DNA replication initiation; G1/S transition of mitotic cell cycle; homologous chromosome pairing at meiosis; mitotic cell cycle phase transition; negative regulation of transcription by RNA polymerase II; positive regulation of mesenchymal stem cell proliferation; protein phosphorylation; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of protein localization; telomere maintenance; Wnt signaling pathway","cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; protein binding; protein kinase binding","centrosome; cyclin E1-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; nucleoplasm; nucleus","Cell cycle control","cyclin E1","http://www.ncbi.nlm.nih.gov/gene/?term=898","898","12447","25729",null,null,null,"P24864","Q61457","B1WC54","A0A8I3MDI8","A0A5G2RGD8","A0A1D5QCQ1","GO:0005813; GO:0097134; GO:0000307; GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0016538; GO:0016301; GO:0005515; GO:0019901","GO:0007049; GO:0051301; GO:0070192; GO:0006270; GO:0000082; GO:0007129; GO:0044772; GO:0000122; GO:1902462; GO:0006468; GO:0051726; GO:0000079; GO:0032880; GO:0000723; GO:0016055","PTHR10177:SF71","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1589|UniProtKB=P24864","P00059; P00049; P00013; P04398"]
["Cyclin E2",null,"CCNE2","50","rb",null,1,4,4,4,4,4,"TK # 066",".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DI., .HEPB., .OP., .P53S., .PARK., .PI3K., .PRC., .RTK., .SCLC.","Parkinson disease; Cell cycle","G1/S-SPECIFIC CYCLIN-E2","cell cycle; cell division; chromosome organization involved in meiotic cell cycle; DNA replication initiation; G1/S transition of mitotic cell cycle; homologous chromosome pairing at meiosis; mitotic cell cycle phase transition; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of protein localization; telomere maintenance","cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein kinase binding","centrosome; cyclin E1-CDK2 complex; cyclin E2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; nucleoplasm; nucleus","Cell cycle control","cyclin E2","http://www.ncbi.nlm.nih.gov/gene/?term=9134","9134","12448","362485",null,null,"700382","O96020","Q9Z238","A0A8I6A291","A0A8I3NWC1","A0A287A1H1","F6Q7B1","GO:0005813; GO:0097134; GO:0097135; GO:0000307; GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0016538; GO:0005515; GO:0019901","GO:0007049; GO:0051301; GO:0070192; GO:0006270; GO:0000082; GO:0007129; GO:0044772; GO:0051726; GO:0000079; GO:0032880; GO:0000723","PTHR10177:SF70","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1590|UniProtKB=O96020","P00049; P00013"]
["Cyp2B6",null,"CYP2B6","57","rb",null,2,2,2,2,2,2,"# 1564",".DRR., .OP., .OT.","Bupropion_degradation","CYTOCHROME P450 2B6","cellular ketone metabolic process; epoxygenase P450 pathway; lipid metabolic process; organic acid metabolic process; steroid metabolic process; xenobiotic catabolic process; xenobiotic metabolic process","anandamide 11,12 epoxidase activity; anandamide 14,15 epoxidase activity; anandamide 8,9 epoxidase activity; arachidonic acid epoxygenase activity; estrogen 2-hydroxylase activity; heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; testosterone 16-alpha-hydroxylase activity; testosterone 16-beta-hydroxylase activity","cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane","Metabolism","cytochrome P450 family 2 subfamily B member 6","http://www.ncbi.nlm.nih.gov/gene/?term=1555","1555","13094","286953",null,null,"678687","P20813","P12790","P13107","A0A8I3MQJ9","A0A286ZQT7","Q6GUQ8","GO:0005737; GO:0005783; GO:0005789; GO:0043231; GO:0016020","GO:0062188; GO:0062189; GO:0062187; GO:0008392; GO:0101021; GO:0020037; GO:0005506; GO:0046872; GO:0004497; GO:0016491; GO:0016705; GO:0016712; GO:0008395; GO:0008390; GO:0062184","GO:0042180; GO:0019373; GO:0006629; GO:0006082; GO:0008202; GO:0042178; GO:0006805","PTHR24300:SF153","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2615|UniProtKB=P20813","P05729"]
["Cyp2B6",null,"CYP2B6","70","rb",null,1,6,"n/a","n/a","n/a","n/a","# 2266",".DRR., .OP., .OT.","Bupropion_degradation","CYTOCHROME P450 2B6","cellular ketone metabolic process; epoxygenase P450 pathway; lipid metabolic process; organic acid metabolic process; steroid metabolic process; xenobiotic catabolic process; xenobiotic metabolic process","anandamide 11,12 epoxidase activity; anandamide 14,15 epoxidase activity; anandamide 8,9 epoxidase activity; arachidonic acid epoxygenase activity; estrogen 2-hydroxylase activity; heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; testosterone 16-alpha-hydroxylase activity; testosterone 16-beta-hydroxylase activity","cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane","Metabolism","cytochrome P450 family 2 subfamily B member 6","http://www.ncbi.nlm.nih.gov/gene/?term=1555","1555","13094","286953",null,null,"678687","P20813","P12790","P13107","A0A8I3MQJ9","A0A286ZQT7","Q6GUQ8","GO:0005737; GO:0005783; GO:0005789; GO:0043231; GO:0016020","GO:0062188; GO:0062189; GO:0062187; GO:0008392; GO:0101021; GO:0020037; GO:0005506; GO:0046872; GO:0004497; GO:0016491; GO:0016705; GO:0016712; GO:0008395; GO:0008390; GO:0062184","GO:0042180; GO:0019373; GO:0006629; GO:0006082; GO:0008202; GO:0042178; GO:0006805","PTHR24300:SF153","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2615|UniProtKB=P20813","P05729"]
["Cyp2C8",null,"CYP2C8","55","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1871",".DRR., .OP., .OT.",null,"CYTOCHROME P450 2C8","arachidonic acid metabolic process; epoxygenase P450 pathway; estrogen metabolic process; icosanoid biosynthetic process; lipid hydroxylation; lipid metabolic process; long-chain fatty acid biosynthetic process; omega-hydroxylase P450 pathway; organic acid metabolic process; oxidative demethylation; retinoic acid metabolic process; retinol metabolic process; steroid metabolic process; xenobiotic catabolic process; xenobiotic metabolic process","arachidonic acid epoxygenase activity; aromatase activity; caffeine oxidase activity; estrogen 16-alpha-hydroxylase activity; heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; protein binding; retinoic acid 4-hydroxylase activity; steroid hydroxylase activity","cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; plasma membrane",null,"cytochrome P450 family 2 subfamily C member 8","http://www.ncbi.nlm.nih.gov/gene/?term=1558","1558",null,null,null,null,null,"P10632",null,null,null,null,"A0A5F7ZG41","GO:0005737; GO:0005783; GO:0005789; GO:0043231; GO:0016020; GO:0005886","GO:0008392; GO:0070330; GO:0034875; GO:0101020; GO:0020037; GO:0005506; GO:0046872; GO:0004497; GO:0016491; GO:0016705; GO:0016712; GO:0005515; GO:0008401; GO:0008395","GO:0019369; GO:0019373; GO:0008210; GO:0046456; GO:0002933; GO:0006629; GO:0042759; GO:0097267; GO:0006082; GO:0070989; GO:0042573; GO:0042572; GO:0008202; GO:0042178; GO:0006805","PTHR24300:SF317","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2622|UniProtKB=P10632"]
["Cyp2E1",null,"CYP2E1","58","rb",null,2.1,2,5,8,1,2,"# 1870",".CSP., .DRR., .OP., .OT., .OXS., .SREME.",null,"CYTOCHROME P450 2E1","4-nitrophenol metabolic process; benzene metabolic process; carbon tetrachloride metabolic process; epoxygenase P450 pathway; fatty acid metabolic process; halogenated hydrocarbon metabolic process; heterocycle metabolic process; lipid hydroxylation; lipid metabolic process; long-chain fatty acid biosynthetic process; long-chain fatty acid metabolic process; monoterpenoid metabolic process; organic acid metabolic process; response to bacterium; response to ethanol; response to organonitrogen compound; response to ozone; response to xenobiotic stimulus; steroid metabolic process; triglyceride metabolic process; xenobiotic metabolic process","4-nitrophenol 2-monooxygenase activity; arachidonic acid epoxygenase activity; aromatase activity; enzyme binding; heme binding; Hsp70 protein binding; Hsp90 protein binding; iron ion binding; long-chain fatty acid omega-1 hydroxylase activity; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; steroid hydroxylase activity","cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; intracellular membrane-bounded organelle; membrane; mitochondrial inner membrane; mitochondrion",null,"cytochrome P450 family 2 subfamily E member 1","http://www.ncbi.nlm.nih.gov/gene/?term=1571","1571","13106",null,null,null,null,"P05181","Q05421","A0A0G2K5X9",null,"A0A5G2R606","A0A1D5QML3","GO:0005737; GO:0005783; GO:0005789; GO:0000139; GO:0043231; GO:0016020; GO:0005743; GO:0005739","GO:0018601; GO:0008392; GO:0070330; GO:0019899; GO:0020037; GO:0030544; GO:0051879; GO:0005506; GO:0120319; GO:0046872; GO:0004497; GO:0016491; GO:0016705; GO:0016709; GO:0016712; GO:0019825; GO:0008395","GO:0018960; GO:0018910; GO:0018885; GO:0019373; GO:0006631; GO:0042197; GO:0046483; GO:0002933; GO:0006629; GO:0042759; GO:0001676; GO:0016098; GO:0006082; GO:0009617; GO:0045471; GO:0010243; GO:0010193; GO:0009410; GO:0008202; GO:0006641; GO:0006805","PTHR24300:SF356","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2631|UniProtKB=P05181"]
["Cyp3A4",null,"CYP3A4","57","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1986",".DRR., .OP., .OT.",null,"CYTOCHROME P450 3A4","aflatoxin metabolic process; alkaloid catabolic process; androgen metabolic process; calcitriol biosynthetic process from calciol; cholesterol metabolic process; estrogen metabolic process; fatty acid metabolic process; heterocycle metabolic process; lipid hydroxylation; lipid metabolic process; long-chain fatty acid biosynthetic process; monoterpenoid metabolic process; oxidative demethylation; retinoic acid metabolic process; retinol metabolic process; steroid biosynthetic process; steroid catabolic process; steroid metabolic process; vitamin D catabolic process; vitamin D metabolic process; xenobiotic catabolic process; xenobiotic metabolic process","1,8-cineole 2-exo-monooxygenase activity; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity; anandamide 11,12 epoxidase activity; anandamide 14,15 epoxidase activity; anandamide 8,9 epoxidase activity; aromatase activity; caffeine oxidase activity; enzyme binding; estrogen 16-alpha-hydroxylase activity; estrogen 2-hydroxylase activity; heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; protein binding; quinine 3-monooxygenase activity; retinoic acid 4-hydroxylase activity; steroid binding; steroid hydroxylase activity; testosterone 6-beta-hydroxylase activity; vitamin D 24-hydroxylase activity; vitamin D3 25-hydroxylase activity","cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane","Metabolism","cytochrome P450 family 3 subfamily A member 4","http://www.ncbi.nlm.nih.gov/gene/?term=1576","1576","100041375",null,null,null,null,"P08684","Q9JMA7","A0A8I6AFH9","A0A8P0PEN0","A0A287AR19",null,"GO:0005737; GO:0005783; GO:0005789; GO:0043231; GO:0016020","GO:0102320; GO:0062181; GO:0062188; GO:0062189; GO:0062187; GO:0070330; GO:0034875; GO:0019899; GO:0101020; GO:0101021; GO:0020037; GO:0005506; GO:0046872; GO:0004497; GO:0016491; GO:0016705; GO:0016712; GO:0019825; GO:0005515; GO:0050591; GO:0008401; GO:0005496; GO:0008395; GO:0050649; GO:0070576; GO:0030343","GO:0046222; GO:0009822; GO:0008209; GO:0036378; GO:0008203; GO:0008210; GO:0006631; GO:0046483; GO:0002933; GO:0006629; GO:0042759; GO:0016098; GO:0070989; GO:0042573; GO:0042572; GO:0006694; GO:0006706; GO:0008202; GO:0042369; GO:0042359; GO:0042178; GO:0006805","PTHR24302:SF38","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2637|UniProtKB=P08684"]
["Cyp3A4",null,"CYP3A4","58","ms",null,6,2,"n/a","n/a","n/a","n/a","# 1231",".DRR., .OP., .OT.",null,"CYTOCHROME P450 3A4","aflatoxin metabolic process; alkaloid catabolic process; androgen metabolic process; calcitriol biosynthetic process from calciol; cholesterol metabolic process; estrogen metabolic process; fatty acid metabolic process; heterocycle metabolic process; lipid hydroxylation; lipid metabolic process; long-chain fatty acid biosynthetic process; monoterpenoid metabolic process; oxidative demethylation; retinoic acid metabolic process; retinol metabolic process; steroid biosynthetic process; steroid catabolic process; steroid metabolic process; vitamin D catabolic process; vitamin D metabolic process; xenobiotic catabolic process; xenobiotic metabolic process","1,8-cineole 2-exo-monooxygenase activity; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity; anandamide 11,12 epoxidase activity; anandamide 14,15 epoxidase activity; anandamide 8,9 epoxidase activity; aromatase activity; caffeine oxidase activity; enzyme binding; estrogen 16-alpha-hydroxylase activity; estrogen 2-hydroxylase activity; heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; protein binding; quinine 3-monooxygenase activity; retinoic acid 4-hydroxylase activity; steroid binding; steroid hydroxylase activity; testosterone 6-beta-hydroxylase activity; vitamin D 24-hydroxylase activity; vitamin D3 25-hydroxylase activity","cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane","Metabolism","cytochrome P450 family 3 subfamily A member 4","http://www.ncbi.nlm.nih.gov/gene/?term=1576","1576","100041375",null,null,null,null,"P08684","Q9JMA7","A0A8I6AFH9","A0A8P0PEN0","A0A287AR19",null,"GO:0005737; GO:0005783; GO:0005789; GO:0043231; GO:0016020","GO:0102320; GO:0062181; GO:0062188; GO:0062189; GO:0062187; GO:0070330; GO:0034875; GO:0019899; GO:0101020; GO:0101021; GO:0020037; GO:0005506; GO:0046872; GO:0004497; GO:0016491; GO:0016705; GO:0016712; GO:0019825; GO:0005515; GO:0050591; GO:0008401; GO:0005496; GO:0008395; GO:0050649; GO:0070576; GO:0030343","GO:0046222; GO:0009822; GO:0008209; GO:0036378; GO:0008203; GO:0008210; GO:0006631; GO:0046483; GO:0002933; GO:0006629; GO:0042759; GO:0016098; GO:0070989; GO:0042573; GO:0042572; GO:0006694; GO:0006706; GO:0008202; GO:0042369; GO:0042359; GO:0042178; GO:0006805","PTHR24302:SF38","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2637|UniProtKB=P08684"]
["Cyp3A5",null,"CYP3A5","57","rb",null,6,2,"n/a","n/a","n/a","n/a","# 1985",".DRR., .OP., .OT.",null,"CYTOCHROME P450 3A5","aflatoxin metabolic process; alkaloid catabolic process; estrogen metabolic process; lipid hydroxylation; lipid metabolic process; oxidative demethylation; retinoic acid metabolic process; retinol metabolic process; steroid metabolic process; xenobiotic catabolic process; xenobiotic metabolic process","aromatase activity; estrogen 16-alpha-hydroxylase activity; heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; protein binding; retinoic acid 4-hydroxylase activity; steroid hydroxylase activity; testosterone 6-beta-hydroxylase activity","endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane","Metabolism","cytochrome P450 family 3 subfamily A member 5","http://www.ncbi.nlm.nih.gov/gene/?term=1577","1577","100041375",null,null,null,null,"P20815","Q9JMA7","A0A8I6AFH9","A0A8P0PEN0","A0A287AR19",null,"GO:0005783; GO:0005789; GO:0043231; GO:0016020","GO:0070330; GO:0101020; GO:0020037; GO:0005506; GO:0046872; GO:0004497; GO:0016491; GO:0016705; GO:0016712; GO:0019825; GO:0005515; GO:0008401; GO:0008395; GO:0050649","GO:0046222; GO:0009822; GO:0008210; GO:0002933; GO:0006629; GO:0070989; GO:0042573; GO:0042572; GO:0008202; GO:0042178; GO:0006805","PTHR24302:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2638|UniProtKB=P20815"]
["Cyp4F2",null,"CYP4F2","56","gt",null,1,7,"n/a","n/a","n/a","n/a","# 1768",".DRR., .OP., .OT., .PLAT.",null,"CYTOCHROME P450 4F2","arachidonic acid metabolic process; blood coagulation; epoxygenase P450 pathway; fatty acid metabolic process; fatty acid omega-oxidation; icosanoid metabolic process; leukotriene B4 catabolic process; leukotriene metabolic process; lipid metabolic process; long-chain fatty acid metabolic process; menaquinone catabolic process; negative regulation of icosanoid secretion; omega-hydroxylase P450 pathway; phylloquinone catabolic process; positive regulation of icosanoid secretion; pressure natriuresis; regulation of blood pressure; renal water homeostasis; sodium ion homeostasis; very long-chain fatty acid metabolic process; vitamin E metabolic process; vitamin K catabolic process; xenobiotic metabolic process","20-aldehyde-leukotriene B4 20-monooxygenase activity; 20-hydroxy-leukotriene B4 omega oxidase activity; alkane 1-monooxygenase activity; alpha-tocopherol omega-hydroxylase activity; arachidonic acid epoxygenase activity; arachidonic acid monooxygenase activity; arachidonic acid omega-hydroxylase activity; aromatase activity; docosanoate omega-hydroxylase activity; heme binding; iron ion binding; leukotriene-B4 20-monooxygenase activity; long-chain fatty acid omega-hydroxylase activity; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; protein binding; tocotrienol omega-hydroxylase activity","apical plasma membrane; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane","Metabolism","cytochrome P450 family 4 subfamily F member 2","http://www.ncbi.nlm.nih.gov/gene/?term=8529","8529","64385","503122",null,null,null,"P78329","Q9EP75","D3ZTC9",null,"A0A287BMK6","A0A5F7ZC86","GO:0016324; GO:0005737; GO:0005783; GO:0005789; GO:0043231; GO:0016020","GO:0097259; GO:0097258; GO:0018685; GO:0052871; GO:0008392; GO:0008391; GO:0052869; GO:0070330; GO:0102207; GO:0020037; GO:0005506; GO:0050051; GO:0102033; GO:0046872; GO:0004497; GO:0016491; GO:0016705; GO:0016709; GO:0005515; GO:0052872","GO:0019369; GO:0007596; GO:0019373; GO:0006631; GO:0010430; GO:0006690; GO:0036101; GO:0006691; GO:0006629; GO:0001676; GO:0042361; GO:0032304; GO:0097267; GO:0042376; GO:0032305; GO:0003095; GO:0008217; GO:0003091; GO:0055078; GO:0000038; GO:0042360; GO:0042377; GO:0006805","PTHR24291:SF124","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2645|UniProtKB=P78329"]
["Cyp7A1",null,"CYP7A1","55","rb",null,2,2,4,4,8,8,"# 1987",".CSP., .DRR., .OP., .OPA., .OT., .ST., .TRASR.",null,"CYTOCHROME P450 7A1","bile acid and bile salt transport; bile acid biosynthetic process; bile acid signaling pathway; cellular response to cholesterol; cellular response to glucose stimulus; cholesterol catabolic process; cholesterol homeostasis; cholesterol metabolic process; lipid metabolic process; negative regulation of collagen biosynthetic process; negative regulation of fatty acid biosynthetic process; positive regulation of cholesterol biosynthetic process; regulation of bile acid biosynthetic process; regulation of gene expression; response to ethanol; response to organic cyclic compound; steroid metabolic process; sterol metabolic process","24-hydroxycholesterol 7alpha-hydroxylase activity; cholesterol 7-alpha-monooxygenase activity; heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; steroid hydroxylase activity","endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane","Metabolism","cytochrome P450 family 7 subfamily A member 1","http://www.ncbi.nlm.nih.gov/gene/?term=1581","1581","13122","25428",null,null,null,"P22680","Q64505","P18125","A0A8I3PV16","A0A286ZQK5","F7HS30","GO:0005783; GO:0005789; GO:0043231; GO:0016020","GO:0033782; GO:0008123; GO:0020037; GO:0005506; GO:0046872; GO:0004497; GO:0016491; GO:0016705; GO:0008395","GO:0015721; GO:0006699; GO:0038183; GO:0071397; GO:0071333; GO:0006707; GO:0042632; GO:0008203; GO:0006629; GO:0032966; GO:0045717; GO:0045542; GO:0070857; GO:0010468; GO:0045471; GO:0014070; GO:0008202; GO:0016125","PTHR24304:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2651|UniProtKB=P22680"]
["CYR61",null,"CCN1","41","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1459",".ANG., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR.",null,"CCN FAMILY MEMBER 1","apoptotic process; apoptotic process involved in heart morphogenesis; atrial septum morphogenesis; atrioventricular valve morphogenesis; cell adhesion; cell-cell adhesion; chemotaxis; chondroblast differentiation; chorio-allantoic fusion; extracellular matrix organization; intussusceptive angiogenesis; labyrinthine layer blood vessel development; negative regulation of apoptotic process; negative regulation of cell death; osteoblast differentiation; positive regulation of apoptotic process; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of cartilage development; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of cell-substrate adhesion; positive regulation of ceramide biosynthetic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of phospholipase activity; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; reactive oxygen species metabolic process; regulation of developmental process; regulation of ERK1 and ERK2 cascade; signal transduction; ventricular septum development; wound healing, spreading of cells","extracellular matrix binding; extracellular matrix structural constituent; growth factor binding; heparin binding; integrin binding; protein binding","collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular matrix; extracellular region","Adhesion","cellular communication network factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=3491","3491","16007",null,"479967","100153791","714970","O00622","P18406","F7FNA9","A0A8I3S8V0","A0A5G2QS80","G7MHT7","GO:0062023; GO:0005788; GO:0031012; GO:0005576","GO:0050840; GO:0005201; GO:0019838; GO:0008201; GO:0005178; GO:0005515","GO:0006915; GO:0003278; GO:0060413; GO:0003181; GO:0007155; GO:0098609; GO:0006935; GO:0060591; GO:0060710; GO:0030198; GO:0002041; GO:0060716; GO:0043066; GO:0060548; GO:0001649; GO:0043065; GO:0030513; GO:0030501; GO:0061036; GO:0045597; GO:0030335; GO:0010811; GO:2000304; GO:0043280; GO:0045669; GO:0033690; GO:0010518; GO:0045860; GO:0001934; GO:0045944; GO:0072593; GO:0050793; GO:0070372; GO:0007165; GO:0003281; GO:0044319","PTHR11348:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2654|UniProtKB=O00622"]
["Cytochrome C",null,"CYCS","14","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2036",".ALZ., .APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .DI., .HEPB., .HUNT., .OP., .P53S., .SCLC.","ATP synthesis; Apoptosis signaling pathway","CYTOCHROME C","activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic process; cellular respiration; intrinsic apoptotic signaling pathway; mitochondrial electron transport, cytochrome c to oxygen; mitochondrial electron transport, ubiquinol to cytochrome c; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process","electron transfer activity; heme binding; metal ion binding; protein binding","apoptosome; cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; nucleus; respirasome",null,"cytochrome c, somatic","http://www.ncbi.nlm.nih.gov/gene/?term=54205","54205","13063","100363502",null,"100170131",null,"P99999","P62897","P62898",null,"P62895","F7G769","GO:0043293; GO:0005829; GO:0005743; GO:0005758; GO:0005739; GO:0005634; GO:0070469","GO:0009055; GO:0020037; GO:0046872; GO:0005515","GO:0097202; GO:0008635; GO:0006915; GO:0045333; GO:0097193; GO:0006123; GO:0006122; GO:0043280","PTHR11961:SF29","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=19986|UniProtKB=P99999","P02721; P00006"]
["Cytokeratin 16",null,"KRT16","48","rb",null,1,6,"n/a","n/a","n/a","n/a","# 0224",".IIR., .IMFR., .IMUR., .MIG., .OP., .OT.",null,"KERATIN, TYPE I CYTOSKELETAL 16","aging; cytoskeleton organization; epithelial cell differentiation; establishment of skin barrier; hair cycle; inflammatory response; innate immune response; intermediate filament cytoskeleton organization; intermediate filament organization; keratinization; keratinocyte differentiation; keratinocyte migration; morphogenesis of an epithelium; negative regulation of cell migration","protein binding; structural constituent of cytoskeleton; structural molecule activity","cornified envelope; cytoskeleton; cytosol; extracellular exosome; intermediate filament; nucleus","Tumor marker","keratin 16","http://www.ncbi.nlm.nih.gov/gene/?term=3868","3868","16666",null,null,null,null,"P08779","Q9Z2K1",null,null,null,null,"GO:0001533; GO:0005856; GO:0005829; GO:0070062; GO:0005882; GO:0005634","GO:0005515; GO:0005200; GO:0005198","GO:0007568; GO:0007010; GO:0030855; GO:0061436; GO:0042633; GO:0006954; GO:0045087; GO:0045104; GO:0045109; GO:0031424; GO:0030216; GO:0051546; GO:0002009; GO:0030336","PTHR23239:SF105","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6423|UniProtKB=P08779"]
["Cytokeratin 17",null,"KRT17","48","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2064",".CCP., .CP., .OP., .OT., .TRASR.",null,"KERATIN, TYPE I CYTOSKELETAL 17","epithelial cell differentiation; hair follicle morphogenesis; intermediate filament organization; keratinization; morphogenesis of an epithelium; positive regulation of cell growth; positive regulation of hair follicle development; positive regulation of translation","protein binding; structural molecule activity","cell periphery; cornified envelope; cytoplasm; cytoskeleton; cytosol; intermediate filament; intermediate filament cytoskeleton; keratin filament","Tumor marker","keratin 17","http://www.ncbi.nlm.nih.gov/gene/?term=3872","3872","16667","287702",null,null,null,"Q04695","Q9QWL7","Q6IFU8",null,null,null,"GO:0071944; GO:0001533; GO:0005737; GO:0005856; GO:0005829; GO:0005882; GO:0045111; GO:0045095","GO:0005515; GO:0005198","GO:0030855; GO:0031069; GO:0045109; GO:0031424; GO:0002009; GO:0030307; GO:0051798; GO:0045727","PTHR23239:SF180","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6427|UniProtKB=Q04695"]
["Cytokeratin 18",null,"KRT18","46","ms",null,1,2,8,8,1,8,"# 1122",".APO., .CCP., .CCY., .CD., .CSP., .IMUF., .INFM., .OP., .TNF.",null,"KERATIN, TYPE I CYTOSKELETAL 18","anatomical structure morphogenesis; cell cycle; cell-cell adhesion; extrinsic apoptotic signaling pathway; Golgi to plasma membrane protein transport; hepatocyte apoptotic process; intermediate filament cytoskeleton organization; negative regulation of apoptotic process; tumor necrosis factor-mediated signaling pathway","cadherin binding involved in cell-cell adhesion; protein binding; RNA binding; scaffold protein binding; structural molecule activity","adherens junction; cell periphery; centriolar satellite; cytoplasm; cytoskeleton; cytosol; extracellular exosome; intermediate filament; keratin filament; microtubule organizing center; nuclear matrix; nucleolus; nucleus; perinuclear region of cytoplasm","Tumor marker","keratin 18","http://www.ncbi.nlm.nih.gov/gene/?term=3875","3875","16668","294853",null,null,null,"P05783","P05784","Q5BJY9",null,"A0A5G2RBD3","F7GUQ6","GO:0005912; GO:0071944; GO:0034451; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005882; GO:0045095; GO:0005815; GO:0016363; GO:0005730; GO:0005634; GO:0048471","GO:0098641; GO:0005515; GO:0003723; GO:0097110; GO:0005198","GO:0009653; GO:0007049; GO:0098609; GO:0097191; GO:0043001; GO:0097284; GO:0045104; GO:0043066; GO:0033209","PTHR23239:SF349","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6430|UniProtKB=P05783"]
["Cytokeratin 19",null,"KRT19","40","ms",null,1,5,4,4,4,4,"# 1791",".CSP., .DEV., .NOTCH.",null,"KERATIN, TYPE I CYTOSKELETAL 19","cell differentiation involved in embryonic placenta development; epithelial cell differentiation; intermediate filament organization; Notch signaling pathway; response to estrogen; sarcomere organization","protein binding; structural constituent of cytoskeleton; structural constituent of muscle; structural molecule activity","apicolateral plasma membrane; cell periphery; costamere; cytoskeleton; cytosol; extracellular exosome; intermediate filament; plasma membrane; sarcolemma; terminal web; Z disc","Tumor marker","keratin 19","http://www.ncbi.nlm.nih.gov/gene/?term=3880","3880","16669",null,null,null,"707129","P08727","P19001",null,null,"A0A287AEL2","F7A635","GO:0016327; GO:0071944; GO:0043034; GO:0005856; GO:0005829; GO:0070062; GO:0005882; GO:0005886; GO:0042383; GO:1990357; GO:0030018","GO:0005515; GO:0005200; GO:0008307; GO:0005198","GO:0060706; GO:0030855; GO:0045109; GO:0007219; GO:0043627; GO:0045214","PTHR23239:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6436|UniProtKB=P08727"]
["Cytokeratin 20",null,"KRT20","48","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2224",".APO., .CD., .CSP.",null,"KERATIN, TYPE I CYTOSKELETAL 20","apoptotic process; cellular response to starvation; epithelial cell differentiation; intermediate filament organization; regulation of protein secretion","protein binding; structural constituent of cytoskeleton; structural molecule activity","cytoplasm; cytoskeleton; cytosol; intermediate filament",null,"keratin 20","http://www.ncbi.nlm.nih.gov/gene/?term=54474","54474","66809",null,null,null,null,"P35900","Q9D312","A0A0G2K623","A0A8P0NN92","A0A5G2QNY4","F7B5A6","GO:0005737; GO:0005856; GO:0005829; GO:0005882","GO:0005515; GO:0005200; GO:0005198","GO:0006915; GO:0009267; GO:0030855; GO:0045109; GO:0050708","PTHR23239:SF167","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20412|UniProtKB=P35900"]
["Cytokeratin 5",null,"KRT5","58","rb",null,1,2,8,8,8,8,"# 0761",".MIG., .OP., .OT.",null,"KERATIN, TYPE II CYTOSKELETAL 5","epidermis development; intermediate filament organization; intermediate filament polymerization; keratinization; regulation of cell migration; regulation of protein localization; response to mechanical stimulus","protein binding; scaffold protein binding; structural constituent of cytoskeleton; structural constituent of skin epidermis","cytoplasm; cytosol; extracellular exosome; intermediate filament; keratin filament; membrane; nucleus","Tumor marker","keratin 5","http://www.ncbi.nlm.nih.gov/gene/?term=3852","3852","110308","369017","486531",null,null,"P13647","Q922U2","Q6P6Q2","A0A8I3PTF9","A0A286ZY68",null,"GO:0005737; GO:0005829; GO:0070062; GO:0005882; GO:0045095; GO:0016020; GO:0005634","GO:0005515; GO:0097110; GO:0005200; GO:0030280","GO:0008544; GO:0045109; GO:0045107; GO:0031424; GO:0030334; GO:0032880; GO:0009612","PTHR45616:SF32","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6442|UniProtKB=P13647"]
["Cytokeratin 6",null,"KRT6A","56","rb",null,1.1000000000000001,4,8,8,8,8,"# 0209",".CCP., .CP., .IMU., .IMUR., .OP.",null,"KERATIN, TYPE II CYTOSKELETAL 6A-RELATED","antimicrobial humoral immune response mediated by antimicrobial peptide; cell differentiation; defense response to Gram-positive bacterium; intermediate filament organization; keratinization; killing of cells of another organism; morphogenesis of an epithelium; negative regulation of entry of bacterium into host cell; positive regulation of cell population proliferation; wound healing","protein binding; structural constituent of cytoskeleton; structural constituent of skin epidermis","cytosol; extracellular exosome; intermediate filament; keratin filament; membrane; nucleus","Tumor marker","keratin 6A","http://www.ncbi.nlm.nih.gov/gene/?term=3853","3853","406223",null,null,null,null,"P02538","Q6IFZ8","A0A0G2JUG1",null,null,null,"GO:0005829; GO:0070062; GO:0005882; GO:0045095; GO:0016020; GO:0005634","GO:0005515; GO:0005200; GO:0030280","GO:0061844; GO:0030154; GO:0050830; GO:0045109; GO:0031424; GO:0031640; GO:0002009; GO:2000536; GO:0008284; GO:0042060","PTHR45616:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6443|UniProtKB=P02538"]
["Cytokeratin 7",null,"KRT7","52","rb",null,1,4,8,8,8,8,"# 0469",null,null,"KERATIN, TYPE II CYTOSKELETAL 7","intermediate filament organization; keratinization","protein binding; structural constituent of skin epidermis","cytoplasm; cytosol; extracellular exosome; intermediate filament; intermediate filament cytoskeleton; keratin filament; nucleus","Tumor marker","keratin 7","http://www.ncbi.nlm.nih.gov/gene/?term=3855","3855","110310",null,null,null,"697425","P08729","Q9DCV7","A0A0G2KAX7",null,null,"F7BW95","GO:0005737; GO:0005829; GO:0070062; GO:0005882; GO:0045111; GO:0045095; GO:0005634","GO:0005515; GO:0030280","GO:0045109; GO:0031424","PTHR45616:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6445|UniProtKB=P08729"]
["Cytokeratin 8",null,"KRT8","55-40","ms",null,1,1,"n/a","n/a","n/a","n/a","# 1646",".APO., .CD., .CSP., .IMUF., .INFM., .TNF.",null,"KERATIN, TYPE II CYTOSKELETAL 8","cell differentiation involved in embryonic placenta development; extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; intermediate filament organization; keratinization; response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway","protein binding; protein-containing complex binding; scaffold protein binding; structural constituent of skin epidermis","apicolateral plasma membrane; cell periphery; cell-cell junction; costamere; cytoplasm; cytosol; dystrophin-associated glycoprotein complex; extracellular exosome; intermediate filament; intermediate filament cytoskeleton; keratin filament; nuclear matrix; nucleoplasm; nucleus; sarcolemma; Z disc",null,"keratin 8","http://www.ncbi.nlm.nih.gov/gene/?term=3856","3856","16691","25626",null,null,null,"P05787","P11679","Q10758",null,"A0A287A8E9",null,"GO:0016327; GO:0071944; GO:0005911; GO:0043034; GO:0005737; GO:0005829; GO:0016010; GO:0070062; GO:0005882; GO:0045111; GO:0045095; GO:0016363; GO:0005654; GO:0005634; GO:0042383; GO:0030018","GO:0005515; GO:0044877; GO:0097110; GO:0030280","GO:0060706; GO:0097191; GO:0097284; GO:0045109; GO:0031424; GO:0051599; GO:0051707; GO:0045214; GO:0033209","PTHR45616:SF26","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6446|UniProtKB=P05787"]
["Cytokeratin 8 - phospho","Ser23","KRT8","52","rb",null,1,2,8,8,8.1,8,"# 0217",".APO., .CD., .CSP., .IMUF., .INFM., .TNF.",null,"KERATIN, TYPE II CYTOSKELETAL 8","cell differentiation involved in embryonic placenta development; extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; intermediate filament organization; keratinization; response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway","protein binding; protein-containing complex binding; scaffold protein binding; structural constituent of skin epidermis","apicolateral plasma membrane; cell periphery; cell-cell junction; costamere; cytoplasm; cytosol; dystrophin-associated glycoprotein complex; extracellular exosome; intermediate filament; intermediate filament cytoskeleton; keratin filament; nuclear matrix; nucleoplasm; nucleus; sarcolemma; Z disc","Tumor marker","keratin 8","http://www.ncbi.nlm.nih.gov/gene/?term=3856","3856","16691","25626",null,null,null,"P05787","P11679","Q10758",null,"A0A287A8E9",null,"GO:0016327; GO:0071944; GO:0005911; GO:0043034; GO:0005737; GO:0005829; GO:0016010; GO:0070062; GO:0005882; GO:0045111; GO:0045095; GO:0016363; GO:0005654; GO:0005634; GO:0042383; GO:0030018","GO:0005515; GO:0044877; GO:0097110; GO:0030280","GO:0060706; GO:0097191; GO:0097284; GO:0045109; GO:0031424; GO:0051599; GO:0051707; GO:0045214; GO:0033209","PTHR45616:SF26","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6446|UniProtKB=P05787"]
["Cytokeratin 8/18",null,"KRT8, KRT18","55, 46","ms",null,1,4,4,4,8,8,"# 1208",".APO., .CCP., .CCY., .CD., .CSP., .IMUF., .INFM., .OP., .TNF.",null,"KERATIN, TYPE II CYTOSKELETAL 8; KERATIN, TYPE I CYTOSKELETAL 18","cell differentiation involved in embryonic placenta development; extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; intermediate filament organization; keratinization; response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway; anatomical structure morphogenesis; cell cycle; cell-cell adhesion; Golgi to plasma membrane protein transport; intermediate filament cytoskeleton organization; negative regulation of apoptotic process","protein binding; protein-containing complex binding; scaffold protein binding; structural constituent of skin epidermis; cadherin binding involved in cell-cell adhesion; RNA binding; structural molecule activity","apicolateral plasma membrane; cell periphery; cell-cell junction; costamere; cytoplasm; cytosol; dystrophin-associated glycoprotein complex; extracellular exosome; intermediate filament; intermediate filament cytoskeleton; keratin filament; nuclear matrix; nucleoplasm; nucleus; sarcolemma; Z disc; adherens junction; centriolar satellite; cytoskeleton; microtubule organizing center; nucleolus; perinuclear region of cytoplasm","Tumor marker","keratin 8; keratin 18","http://www.ncbi.nlm.nih.gov/gene/?term=3856, http://www.ncbi.nlm.nih.gov/gene/?term=3875","3856, 3875","16691, 16668","25626, 294853","",null,"","P05787, P05783","P11679, P05784","Q10758, Q5BJY9",null,"A0A287A8E9, A0A5G2RBD3","F7GUQ6","GO:0016327; GO:0071944; GO:0005911; GO:0043034; GO:0005737; GO:0005829; GO:0016010; GO:0070062; GO:0005882; GO:0045111; GO:0045095; GO:0016363; GO:0005654; GO:0005634; GO:0042383; GO:0030018; GO:0005912; GO:0034451; GO:0005856; GO:0005815; GO:0005730; GO:0048471","GO:0005515; GO:0044877; GO:0097110; GO:0030280; GO:0098641; GO:0003723; GO:0005198","GO:0060706; GO:0097191; GO:0097284; GO:0045109; GO:0031424; GO:0051599; GO:0051707; GO:0045214; GO:0033209; GO:0009653; GO:0007049; GO:0098609; GO:0043001; GO:0045104; GO:0043066","PTHR45616:SF26; PTHR23239:SF349","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6446|UniProtKB=P05787; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6430|UniProtKB=P05783"]
["Cytokeratin Pan (4, 5, 6, 8, 10, 13, 18)",null,"KRT4, KRT5, KRT6A, KRT8, KRT10, KRT13, KRT18","58-46","ms",null,1,2,1,8,1,1,"# 1779",".APO., .CCP., .CCY., .CD., .CP., .CSP., .IMU., .IMUF., .IMUR., .INFM., .MIG., .OP., .OT., .TNF., .TRASR.",null,"KERATIN, TYPE II CYTOSKELETAL 4; KERATIN, TYPE II CYTOSKELETAL 5; KERATIN, TYPE II CYTOSKELETAL 6A-RELATED; KERATIN, TYPE II CYTOSKELETAL 8; KERATIN, TYPE I CYTOSKELETAL 10; KERATIN, TYPE I CYTOSKELETAL 13; KERATIN, TYPE I CYTOSKELETAL 18","cytoskeleton organization; epithelial cell differentiation; intermediate filament organization; keratinization; negative regulation of epithelial cell proliferation; epidermis development; intermediate filament polymerization; regulation of cell migration; regulation of protein localization; response to mechanical stimulus; antimicrobial humoral immune response mediated by antimicrobial peptide; cell differentiation; defense response to Gram-positive bacterium; killing of cells of another organism; morphogenesis of an epithelium; negative regulation of entry of bacterium into host cell; positive regulation of cell population proliferation; wound healing; cell differentiation involved in embryonic placenta development; extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway; keratinocyte differentiation; peptide cross-linking; positive regulation of epidermis development; protein heterotetramerization; regulation of translation in response to stress; anatomical structure morphogenesis; cell cycle; cell-cell adhesion; Golgi to plasma membrane protein transport; intermediate filament cytoskeleton organization; negative regulation of apoptotic process","protein binding; structural constituent of skin epidermis; scaffold protein binding; structural constituent of cytoskeleton; protein-containing complex binding; protein heterodimerization activity; structural molecule activity; cadherin binding involved in cell-cell adhesion; RNA binding","cell surface; cytosol; intermediate filament; intermediate filament cytoskeleton; keratin filament; nucleus; cytoplasm; extracellular exosome; membrane; apicolateral plasma membrane; cell periphery; cell-cell junction; costamere; dystrophin-associated glycoprotein complex; nuclear matrix; nucleoplasm; sarcolemma; Z disc; cornified envelope; cytoskeleton; extracellular region; extracellular space; adherens junction; centriolar satellite; microtubule organizing center; nucleolus; perinuclear region of cytoplasm",null,"keratin 4; keratin 5; keratin 6A; keratin 8; keratin 10; keratin 13; keratin 18","http://www.ncbi.nlm.nih.gov/gene/?term=3851, http://www.ncbi.nlm.nih.gov/gene/?term=3852, http://www.ncbi.nlm.nih.gov/gene/?term=3853, http://www.ncbi.nlm.nih.gov/gene/?term=3856, http://www.ncbi.nlm.nih.gov/gene/?term=3858, http://www.ncbi.nlm.nih.gov/gene/?term=3860, http://www.ncbi.nlm.nih.gov/gene/?term=3875","3851, 3852, 3853, 3856, 3858, 3860, 3875","16682, 110308, 406223, 16691, NA, 16663, 16668","315323, 369017, NA, 25626, 450225, 287699, 294853","486531, 491006","NA, 100519971","NA, 706830","P19013, P13647, P02538, P05787, P13645, P13646, P05783","P07744, Q922U2, Q6IFZ8, P11679, A0A1B0GSR7, P08730, P05784","A0A0G2K6P7, Q6P6Q2, A0A0G2JUG1, Q10758, Q6IFW6, Q6IFV4, Q5BJY9","A0A8I3PTF9, Q6EIZ0","A0A286ZPQ6, A0A286ZY68, A0A287A8E9, I3LDS3, A0A5G2QXD3, A0A5G2RBD3","F6VKQ3, F7B5G7, A0A1D5Q3N1, F7GUQ6","GO:0009986; GO:0005829; GO:0005882; GO:0045111; GO:0045095; GO:0005634; GO:0005737; GO:0070062; GO:0016020; GO:0016327; GO:0071944; GO:0005911; GO:0043034; GO:0016010; GO:0016363; GO:0005654; GO:0042383; GO:0030018; GO:0001533; GO:0005856; GO:0005576; GO:0005615; GO:0005912; GO:0034451; GO:0005815; GO:0005730; GO:0048471","GO:0005515; GO:0030280; GO:0097110; GO:0005200; GO:0044877; GO:0046982; GO:0005198; GO:0098641; GO:0003723","GO:0007010; GO:0030855; GO:0045109; GO:0031424; GO:0050680; GO:0008544; GO:0045107; GO:0030334; GO:0032880; GO:0009612; GO:0061844; GO:0030154; GO:0050830; GO:0031640; GO:0002009; GO:2000536; GO:0008284; GO:0042060; GO:0060706; GO:0097191; GO:0097284; GO:0051599; GO:0051707; GO:0045214; GO:0033209; GO:0030216; GO:0018149; GO:0045684; GO:0051290; GO:0043555; GO:0009653; GO:0007049; GO:0098609; GO:0043001; GO:0045104; GO:0043066","PTHR45616:SF3; PTHR45616:SF32; PTHR45616:SF39; PTHR45616:SF26; PTHR23239:SF137; PTHR23239:SF121; PTHR23239:SF349","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6441|UniProtKB=P19013; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6442|UniProtKB=P13647; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6443|UniProtKB=P02538; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6446|UniProtKB=P05787; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6413|UniProtKB=P13645; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6415|UniProtKB=P13646; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6430|UniProtKB=P05783"]
["Cytokeratin Pan (5, 6, 8, 17, 19)",null,"KRT5, KRT6A, KRT8, KRT17, KRT19","68-40","ms",null,1,2,1,8,1,8,"# 0261",".APO., .CCP., .CD., .CP., .CSP., .DEV., .IMU., .IMUF., .IMUR., .INFM., .MIG., .NOTCH., .OP., .OT., .TNF., .TRASR.",null,"KERATIN, TYPE II CYTOSKELETAL 5; KERATIN, TYPE II CYTOSKELETAL 6A-RELATED; KERATIN, TYPE II CYTOSKELETAL 8; KERATIN, TYPE I CYTOSKELETAL 17; KERATIN, TYPE I CYTOSKELETAL 19","epidermis development; intermediate filament organization; intermediate filament polymerization; keratinization; regulation of cell migration; regulation of protein localization; response to mechanical stimulus; antimicrobial humoral immune response mediated by antimicrobial peptide; cell differentiation; defense response to Gram-positive bacterium; killing of cells of another organism; morphogenesis of an epithelium; negative regulation of entry of bacterium into host cell; positive regulation of cell population proliferation; wound healing; cell differentiation involved in embryonic placenta development; extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway; epithelial cell differentiation; hair follicle morphogenesis; positive regulation of cell growth; positive regulation of hair follicle development; positive regulation of translation; Notch signaling pathway; response to estrogen","protein binding; scaffold protein binding; structural constituent of cytoskeleton; structural constituent of skin epidermis; protein-containing complex binding; structural molecule activity; structural constituent of muscle","cytoplasm; cytosol; extracellular exosome; intermediate filament; keratin filament; membrane; nucleus; apicolateral plasma membrane; cell periphery; cell-cell junction; costamere; dystrophin-associated glycoprotein complex; intermediate filament cytoskeleton; nuclear matrix; nucleoplasm; sarcolemma; Z disc; cornified envelope; cytoskeleton; plasma membrane; terminal web","Tumor marker","keratin 5; keratin 6A; keratin 8; keratin 17; keratin 19","http://www.ncbi.nlm.nih.gov/gene/?term=3852, http://www.ncbi.nlm.nih.gov/gene/?term=3853, http://www.ncbi.nlm.nih.gov/gene/?term=3856, http://www.ncbi.nlm.nih.gov/gene/?term=3872, http://www.ncbi.nlm.nih.gov/gene/?term=3880","3852, 3853, 3856, 3872, 3880","110308, 406223, 16691, 16667, 16669","369017, NA, 25626, 287702","486531",null,"707129","P13647, P02538, P05787, Q04695, P08727","Q922U2, Q6IFZ8, P11679, Q9QWL7, P19001","Q6P6Q2, A0A0G2JUG1, Q10758, Q6IFU8","A0A8I3PTF9","A0A286ZY68, A0A287A8E9, A0A287AEL2","F7A635","GO:0005737; GO:0005829; GO:0070062; GO:0005882; GO:0045095; GO:0016020; GO:0005634; GO:0016327; GO:0071944; GO:0005911; GO:0043034; GO:0016010; GO:0045111; GO:0016363; GO:0005654; GO:0042383; GO:0030018; GO:0001533; GO:0005856; GO:0005886; GO:1990357","GO:0005515; GO:0097110; GO:0005200; GO:0030280; GO:0044877; GO:0005198; GO:0008307","GO:0008544; GO:0045109; GO:0045107; GO:0031424; GO:0030334; GO:0032880; GO:0009612; GO:0061844; GO:0030154; GO:0050830; GO:0031640; GO:0002009; GO:2000536; GO:0008284; GO:0042060; GO:0060706; GO:0097191; GO:0097284; GO:0051599; GO:0051707; GO:0045214; GO:0033209; GO:0030855; GO:0031069; GO:0030307; GO:0051798; GO:0045727; GO:0007219; GO:0043627","PTHR45616:SF32; PTHR45616:SF39; PTHR45616:SF26; PTHR23239:SF180; PTHR23239:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6442|UniProtKB=P13647; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6443|UniProtKB=P02538; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6446|UniProtKB=P05787; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6427|UniProtKB=Q04695; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6436|UniProtKB=P08727"]
["Cytokeratin Pan (most acidic, all basic)",null,"KRT5, KRT6A, KRT8","68-40","ms",null,1,1,1,2,2,2,"# 0588",".APO., .CCP., .CD., .CP., .CSP., .IMU., .IMUF., .IMUR., .INFM., .MIG., .OP., .OT., .TNF.",null,"KERATIN, TYPE II CYTOSKELETAL 5; KERATIN, TYPE II CYTOSKELETAL 6A-RELATED; KERATIN, TYPE II CYTOSKELETAL 8","epidermis development; intermediate filament organization; intermediate filament polymerization; keratinization; regulation of cell migration; regulation of protein localization; response to mechanical stimulus; antimicrobial humoral immune response mediated by antimicrobial peptide; cell differentiation; defense response to Gram-positive bacterium; killing of cells of another organism; morphogenesis of an epithelium; negative regulation of entry of bacterium into host cell; positive regulation of cell population proliferation; wound healing; cell differentiation involved in embryonic placenta development; extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway","protein binding; scaffold protein binding; structural constituent of cytoskeleton; structural constituent of skin epidermis; protein-containing complex binding","cytoplasm; cytosol; extracellular exosome; intermediate filament; keratin filament; membrane; nucleus; apicolateral plasma membrane; cell periphery; cell-cell junction; costamere; dystrophin-associated glycoprotein complex; intermediate filament cytoskeleton; nuclear matrix; nucleoplasm; sarcolemma; Z disc","Tumor marker","keratin 5; keratin 6A; keratin 8","http://www.ncbi.nlm.nih.gov/gene/?term=3852, http://www.ncbi.nlm.nih.gov/gene/?term=3853, http://www.ncbi.nlm.nih.gov/gene/?term=3856","3852, 3853, 3856","110308, 406223, 16691","369017, NA, 25626","486531",null,"","P13647, P02538, P05787","Q922U2, Q6IFZ8, P11679","Q6P6Q2, A0A0G2JUG1, Q10758","A0A8I3PTF9","A0A286ZY68, A0A287A8E9",null,"GO:0005737; GO:0005829; GO:0070062; GO:0005882; GO:0045095; GO:0016020; GO:0005634; GO:0016327; GO:0071944; GO:0005911; GO:0043034; GO:0016010; GO:0045111; GO:0016363; GO:0005654; GO:0042383; GO:0030018","GO:0005515; GO:0097110; GO:0005200; GO:0030280; GO:0044877","GO:0008544; GO:0045109; GO:0045107; GO:0031424; GO:0030334; GO:0032880; GO:0009612; GO:0061844; GO:0030154; GO:0050830; GO:0031640; GO:0002009; GO:2000536; GO:0008284; GO:0042060; GO:0060706; GO:0097191; GO:0097284; GO:0051599; GO:0051707; GO:0045214; GO:0033209","PTHR45616:SF32; PTHR45616:SF39; PTHR45616:SF26","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6442|UniProtKB=P13647; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6443|UniProtKB=P02538; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6446|UniProtKB=P05787"]
["Dab2",null,"DAB2","96","rb",null,6,4,4,4,4,4,"# 1464",".APO., .CCP., .CD., .CP., .CSP., .DEV., .EGFR., .INT., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .ST., .TGFB., .TRASR., .WNT.",null,"DISABLED HOMOLOG 2","apoptotic process; cell differentiation; cellular response to epidermal growth factor stimulus; cellular response to transforming growth factor beta stimulus; clathrin coat assembly; endocytosis; integrin-mediated signaling pathway; leading edge cell differentiation; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of neuron projection development; negative regulation of protein binding; negative regulation of protein localization to plasma membrane; negative regulation of transcription by RNA polymerase II; positive regulation of aldosterone biosynthetic process; positive regulation of aldosterone secretion; positive regulation of cell migration; positive regulation of clathrin-dependent endocytosis; positive regulation of early endosome to late endosome transport; positive regulation of endocytosis; positive regulation of epithelial to mesenchymal transition; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein phosphorylation; positive regulation of SMAD protein signal transduction; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; protein transport; receptor-mediated endocytosis; regulation of Rho-dependent protein serine/threonine kinase activity; response to salt; response to steroid hormone; Wnt signaling pathway","cargo receptor activity; clathrin adaptor activity; low-density lipoprotein particle receptor binding; protein binding; protein C-terminus binding; SMAD binding","clathrin-coated pit; clathrin-coated vesicle; clathrin-coated vesicle membrane; cytoplasm; cytoplasmic vesicle; cytosol; fibrillar center; focal adhesion; intracellular membrane-bounded organelle; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane","Cytoskeletal signaling","DAB adaptor protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=1601","1601","13132","79128",null,null,null,"P98082","A0A0R4J104","O88797","A0A8I3MJ40","A0A287A8N7","A0A5F8AM64","GO:0005905; GO:0030136; GO:0030665; GO:0005737; GO:0031410; GO:0005829; GO:0001650; GO:0005925; GO:0043231; GO:0005765; GO:0016020; GO:0048471; GO:0005886","GO:0038024; GO:0035615; GO:0050750; GO:0005515; GO:0008022; GO:0046332","GO:0006915; GO:0030154; GO:0071364; GO:0071560; GO:0048268; GO:0006897; GO:0007229; GO:0035026; GO:0060766; GO:0043066; GO:0090090; GO:0030308; GO:0050680; GO:0070373; GO:0010977; GO:0032091; GO:1903077; GO:0000122; GO:0032349; GO:2000860; GO:0030335; GO:2000370; GO:2000643; GO:0045807; GO:0010718; GO:0010862; GO:0032436; GO:0001934; GO:0060391; GO:1900026; GO:0045944; GO:0030511; GO:2000096; GO:0015031; GO:0006898; GO:2000298; GO:1902074; GO:0048545; GO:0016055","PTHR47695:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2662|UniProtKB=P98082"]
["DAPK3 (ZIPK)",null,"DAPK3","52","rb",null,2.1,1,1,1,2.1,1,"# 1011",".APH., .APO., .BLC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CSP., .DEV., .IIR., .IMUR., .MIG., .OP., .OPA., .OT., .ST., .TRASR., .WNT.",null,"DEATH-ASSOCIATED PROTEIN KINASE 3","apoptotic process; apoptotic signaling pathway; cellular response to type II interferon; chromatin organization; intracellular signal transduction; negative regulation of translation; phosphorylation; positive regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton reorganization; regulation of apoptotic process; regulation of autophagy; regulation of cell motility; regulation of cell shape; regulation of DNA-templated transcription; regulation of focal adhesion assembly; regulation of mitotic cell cycle; regulation of mitotic nuclear division; regulation of myosin II filament organization; regulation of smooth muscle contraction; regulation of translation","ATP binding; cAMP response element binding protein binding; identical protein binding; kinase activity; leucine zipper domain binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus; PML body","Apoptosis","death associated protein kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=1613","1613","13144","64391",null,null,null,"O43293","O54784","O88764","A0A8I3N209",null,"A0A1D5QUH7","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0016605","GO:0005524; GO:0008140; GO:0042802; GO:0016301; GO:0043522; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0106310; GO:0004674; GO:0031267; GO:0016740","GO:0006915; GO:0097190; GO:0071346; GO:0006325; GO:0035556; GO:0017148; GO:0016310; GO:0043065; GO:0090263; GO:0030335; GO:0046777; GO:0006468; GO:2000249; GO:0042981; GO:0010506; GO:2000145; GO:0008360; GO:0006355; GO:0051893; GO:0007346; GO:0007088; GO:0043519; GO:0006940; GO:0006417","PTHR24342:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2676|UniProtKB=O43293"]
["DAPK3 (ZIPK) - phospho","Thr265","DAPK3","53","rb",null,6,6,6,6,7,7,"# 1019",".APH., .APO., .BLC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CSP., .DEV., .IIR., .IMUR., .MIG., .OP., .OPA., .OT., .ST., .TRASR., .WNT.",null,"DEATH-ASSOCIATED PROTEIN KINASE 3","apoptotic process; apoptotic signaling pathway; cellular response to type II interferon; chromatin organization; intracellular signal transduction; negative regulation of translation; phosphorylation; positive regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton reorganization; regulation of apoptotic process; regulation of autophagy; regulation of cell motility; regulation of cell shape; regulation of DNA-templated transcription; regulation of focal adhesion assembly; regulation of mitotic cell cycle; regulation of mitotic nuclear division; regulation of myosin II filament organization; regulation of smooth muscle contraction; regulation of translation","ATP binding; cAMP response element binding protein binding; identical protein binding; kinase activity; leucine zipper domain binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus; PML body","Apoptosis","death associated protein kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=1613","1613","13144","64391",null,null,null,"O43293","O54784","O88764","A0A8I3N209",null,"A0A1D5QUH7","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0016605","GO:0005524; GO:0008140; GO:0042802; GO:0016301; GO:0043522; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0106310; GO:0004674; GO:0031267; GO:0016740","GO:0006915; GO:0097190; GO:0071346; GO:0006325; GO:0035556; GO:0017148; GO:0016310; GO:0043065; GO:0090263; GO:0030335; GO:0046777; GO:0006468; GO:2000249; GO:0042981; GO:0010506; GO:2000145; GO:0008360; GO:0006355; GO:0051893; GO:0007346; GO:0007088; GO:0043519; GO:0006940; GO:0006417","PTHR24342:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2676|UniProtKB=O43293"]
["DAZL",null,"DAZL","38","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1703",".OP., .OT., .TRASR.",null,"DELETED IN AZOOSPERMIA-LIKE","3'-UTR-mediated mRNA stabilization; cell differentiation; germ cell development; positive regulation of translational initiation; regulation of translation; spermatogenesis","mRNA 3'-UTR binding; nucleic acid binding; protein binding; RNA binding; translation activator activity","cytoplasm; nucleus; protein-containing complex",null,"deleted in azoospermia like","http://www.ncbi.nlm.nih.gov/gene/?term=1618","1618",null,null,null,"100625706",null,"Q92904",null,null,null,"A0A1B2TT46","A0A1D5QYD7","GO:0005737; GO:0005634; GO:0032991","GO:0003730; GO:0003676; GO:0005515; GO:0003723; GO:0008494","GO:0070935; GO:0030154; GO:0007281; GO:0045948; GO:0006417; GO:0007283","PTHR11176:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2685|UniProtKB=Q92904"]
["Dematin",null,"DMTN","52-48","ms",null,1,1,1,8,2.1,8,"# 0513",".cAMP., .CSP., .GPCR., .INT., .MIG., .OP., .OPA., .OT., .PLAT., .ST.",null,"DEMATIN","actin cytoskeleton organization; actin filament bundle assembly; actin filament capping; actin filament reorganization; calcium-mediated signaling using extracellular calcium source; calcium-mediated signaling using intracellular calcium source; cellular response to calcium ion; cellular response to cAMP; cytoskeleton organization; erythrocyte development; lamellipodium assembly; negative regulation of cell-substrate adhesion; negative regulation of focal adhesion assembly; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-threonine phosphorylation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein targeting to membrane; negative regulation of substrate adhesion-dependent cell spreading; positive regulation of blood coagulation; positive regulation of fibroblast migration; positive regulation of integrin-mediated signaling pathway; positive regulation of platelet aggregation; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of wound healing; protein secretion by platelet; protein-containing complex assembly; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of filopodium assembly; regulation of lamellipodium assembly","actin binding; actin filament binding; protein binding; protein self-association; signaling receptor binding; spectrin binding","actin cytoskeleton; actin filament; cell projection; cell projection membrane; cellular anatomical entity; cortical cytoskeleton; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endomembrane system; membrane; perinuclear region of cytoplasm; plasma membrane; platelet dense tubular network membrane; postsynaptic density; spectrin-associated cytoskeleton","MAPK signaling","dematin actin binding protein","http://www.ncbi.nlm.nih.gov/gene/?term=2039","2039","13829","361069",null,null,null,"Q08495","Q9WV69","A0A8I5ZXT2","A0A8I3Q2X0","A0A287AUM6","A0A1D5QC19","GO:0015629; GO:0005884; GO:0042995; GO:0031253; GO:0110165; GO:0030863; GO:0005737; GO:0031410; GO:0005856; GO:0005829; GO:0012505; GO:0016020; GO:0048471; GO:0005886; GO:0031095; GO:0014069; GO:0014731","GO:0003779; GO:0051015; GO:0005515; GO:0043621; GO:0005102; GO:0030507","GO:0030036; GO:0051017; GO:0051693; GO:0090527; GO:0035585; GO:0035584; GO:0071277; GO:0071320; GO:0007010; GO:0048821; GO:0030032; GO:0010812; GO:0051895; GO:0033137; GO:0010801; GO:0050732; GO:0090315; GO:1900025; GO:0030194; GO:0010763; GO:2001046; GO:1901731; GO:1900026; GO:0090303; GO:0070560; GO:0065003; GO:0032956; GO:0008360; GO:0051489; GO:0010591","PTHR24213:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3382|UniProtKB=Q08495"]
["DEPDC7 - DEP domain containing 7",null,"DEPDC7","58","rb",null,2,1,1,6,6,6,"# 0929",".CSP., .OPA., .ST.",null,"DEP DOMAIN-CONTAINING PROTEIN 7","biological_process; intracellular signal transduction","molecular_function","cellular_component",null,"DEP domain containing 7","http://www.ncbi.nlm.nih.gov/gene/?term=91614","91614","211896","295971","483435",null,"694433","Q96QD5","Q91WS7","Q4QR86","A0A8P0N9X6",null,"A0A5F8ANY1","GO:0005575","GO:0003674","GO:0008150; GO:0035556","PTHR16206:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=29899|UniProtKB=Q96QD5"]
["DEPTOR/DEPDC6",null,"DEPTOR","48","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2355",".APH., .APO., .CD., .CSP., .CUR., .D300., .DMTOR., .MTOR., .OPA., .RTK., .ST.",null,"DEP DOMAIN-CONTAINING MTOR-INTERACTING PROTEIN","intracellular signal transduction; negative regulation of cell size; negative regulation of protein kinase activity; negative regulation of TOR signaling; negative regulation of TORC1 signaling; negative regulation of TORC2 signaling; regulation of catalytic activity; regulation of extrinsic apoptotic signaling pathway","protein binding",null,null,"DEP domain containing MTOR interacting protein","http://www.ncbi.nlm.nih.gov/gene/?term=64798","64798","97998",null,null,null,null,"Q8TB45","Q570Y9","A0A8I5ZQX9","A0A8I3MWD9",null,"A0A1D5QLA5",null,"GO:0005515","GO:0035556; GO:0045792; GO:0006469; GO:0032007; GO:1904262; GO:1903940; GO:0050790; GO:2001236","PTHR22829:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=22953|UniProtKB=Q8TB45"]
["Desmin",null,"DES","53","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1529",null,null,"DESMIN","cytoskeleton organization; intermediate filament organization; muscle contraction; regulation of heart contraction; skeletal muscle organ development","cytoskeletal protein binding; identical protein binding; protein binding; structural constituent of cytoskeleton","cardiac myofibril; cell-cell junction; contractile fiber; cytoplasm; cytoskeleton; cytosol; extracellular exosome; fascia adherens; intercalated disc; intermediate filament; intermediate filament cytoskeleton; membrane; neuromuscular junction; nucleus; plasma membrane; sarcolemma; Z disc","Cytoskeletal signaling","desmin","http://www.ncbi.nlm.nih.gov/gene/?term=1674","1674","13346",null,null,"396725",null,"P17661","P31001","A0A8I6ANC1","A0A8P0SJT2","P02540","A0A5F7Z9F5","GO:0097512; GO:0005911; GO:0043292; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005916; GO:0014704; GO:0005882; GO:0045111; GO:0016020; GO:0031594; GO:0005634; GO:0005886; GO:0042383; GO:0030018","GO:0008092; GO:0042802; GO:0005515; GO:0005200","GO:0007010; GO:0045109; GO:0006936; GO:0008016; GO:0060538","PTHR45652:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2770|UniProtKB=P17661"]
["DFF45",null,"DFFA","45","ms",null,1,4,4,4,5,4,"# 0514",".APO., .CD., .CSP.",null,"CIDE-N DOMAIN-CONTAINING PROTEIN","apoptotic DNA fragmentation; apoptotic process; chaperone-mediated protein folding; negative regulation of apoptotic DNA fragmentation; negative regulation of deoxyribonuclease activity; negative regulation of execution phase of apoptosis; positive regulation of apoptotic process; regulation of apoptotic process; thymocyte apoptotic process","deoxyribonuclease inhibitor activity; molecular adaptor activity; protein binding; protein domain specific binding; protein folding chaperone","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; protein-containing complex","Apoptosis / autophagy","DNA fragmentation factor subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=1676","1676","13347",null,null,null,null,"O00273","O54786","A0A8I6ANF5","A0A8I3MHQ9","A0A287BAG3","A0A5F7ZGG1","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005886; GO:0032991","GO:0060703; GO:0060090; GO:0005515; GO:0019904; GO:0044183","GO:0006309; GO:0006915; GO:0061077; GO:1902511; GO:0032076; GO:1900118; GO:0043065; GO:0042981; GO:0070242","PTHR12306:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2772|UniProtKB=O00273"]
["DGK theta",null,"DGKQ","110","ms",null,7,5,"n/a","n/a","n/a","n/a","# 1582",".cAMP., .CSP., .DRR., .GPCR., .GPROT., .MTOR., .OP., .OPA., .OT., .PLAT., .RTK., .ST., .TRASR.",null,"DIACYLGLYCEROL KINASE THETA","cAMP-mediated signaling; diacylglycerol metabolic process; G protein-coupled receptor signaling pathway; glycerolipid metabolic process; intracellular signal transduction; lipid metabolic process; lipid phosphorylation; negative regulation of gene expression; negative regulation of peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; phosphatidic acid biosynthetic process; phosphorylation; platelet activation; positive regulation of gene expression; positive regulation of peptidyl-tyrosine phosphorylation; protein kinase C signaling; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of cholesterol metabolic process; regulation of cortisol biosynthetic process; regulation of G protein-coupled receptor signaling pathway; regulation of gluconeogenesis; regulation of progesterone biosynthetic process; regulation of synaptic vesicle endocytosis; regulation of TORC1 signaling; regulation of transcription by RNA polymerase II; response to ATP; response to cAMP; signal transduction; thrombin-activated receptor signaling pathway","ATP binding; diacylglycerol kinase activity; DNA-binding transcription factor binding; kinase activity; kinase binding; metal ion binding; nucleotide binding; phospholipase binding; protein binding; transferase activity; transmembrane receptor protein tyrosine kinase activator activity","cytoplasm; cytoskeleton; cytosol; endosome; glutamatergic synapse; membrane; nuclear matrix; nuclear speck; nucleus; plasma membrane; postsynapse; presynapse; synapse; vesicle membrane",null,"diacylglycerol kinase theta","http://www.ncbi.nlm.nih.gov/gene/?term=1609","1609","110524","100361138",null,null,null,"P52824","Q6P5E8","D3ZEY4","A0A8I3MCV4","A0A287A8Z1","F7HE38","GO:0005737; GO:0005856; GO:0005829; GO:0005768; GO:0098978; GO:0016020; GO:0016363; GO:0016607; GO:0005634; GO:0005886; GO:0098794; GO:0098793; GO:0045202; GO:0012506","GO:0005524; GO:0004143; GO:0140297; GO:0016301; GO:0019900; GO:0046872; GO:0000166; GO:0043274; GO:0005515; GO:0016740; GO:0030297","GO:0019933; GO:0046339; GO:0007186; GO:0046486; GO:0035556; GO:0006629; GO:0046834; GO:0010629; GO:0010801; GO:0018105; GO:0006654; GO:0016310; GO:0030168; GO:0010628; GO:0050731; GO:0070528; GO:0007205; GO:0090181; GO:2000064; GO:0008277; GO:0006111; GO:2000182; GO:1900242; GO:1903432; GO:0006357; GO:0033198; GO:0051591; GO:0007165; GO:0070493","PTHR11255:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2856|UniProtKB=P52824"]
["Dicer1",null,"DICER1","217","ms",null,1.1000000000000001,4,4,4,4,4,"# 1408",".CCP., .CP., .CSP., .IMUF., .NFKB., .OP., .OT., .TRASR.",null,"ENDORIBONUCLEASE DICER","apoptotic DNA fragmentation; global gene silencing by mRNA cleavage; miRNA metabolic process; miRNA processing; negative regulation of gene expression; negative regulation of Schwann cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; nerve development; neuron projection morphogenesis; NIK/NF-kappaB signaling; peripheral nervous system myelin formation; positive regulation of myelination; positive regulation of Schwann cell differentiation; pre-miRNA processing; RISC complex assembly; RNA phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, endonucleolytic; RNA processing; RNA-mediated gene silencing; siRNA processing; tRNA catabolic process","ATP binding; deoxyribonuclease I activity; DNA binding; double-stranded RNA binding; endonuclease activity; endoribonuclease activity; endoribonuclease activity, producing 5'-phosphomonoesters; helicase activity; hydrolase activity; metal ion binding; nuclease activity; nucleotide binding; pre-miRNA binding; protein binding; protein domain specific binding; ribonuclease III activity; RNA binding; siRNA binding","cytoplasm; cytosol; extracellular exosome; nucleus; perinuclear region of cytoplasm; RISC complex; RISC-loading complex","Translational control","dicer 1, ribonuclease III","http://www.ncbi.nlm.nih.gov/gene/?term=23405","23405",null,"299284",null,null,null,"Q9UPY3","A0A1Y7VJD6","E9PU15","A0A8I3MJK7","A0A286ZR26","A0A5F7ZPU4","GO:0005737; GO:0005829; GO:0070062; GO:0005634; GO:0048471; GO:0016442; GO:0070578","GO:0005524; GO:0004530; GO:0003677; GO:0003725; GO:0004519; GO:0004521; GO:0016891; GO:0004386; GO:0016787; GO:0046872; GO:0004518; GO:0000166; GO:0070883; GO:0005515; GO:0019904; GO:0004525; GO:0003723; GO:0035197","GO:0006309; GO:0098795; GO:0010586; GO:0035196; GO:0010629; GO:0010626; GO:0000122; GO:0032720; GO:0021675; GO:0048812; GO:0038061; GO:0032290; GO:0031643; GO:0014040; GO:0031054; GO:0070922; GO:0090501; GO:0090502; GO:0006396; GO:0031047; GO:0030422; GO:0016078","PTHR14950:SF37","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17098|UniProtKB=Q9UPY3"]
["Dihydropyrimidin dehydrogenase (DPYD)",null,"DPYD","128","gt",null,7,2,"n/a","n/a","n/a","n/a","# 0484",null,"Pyrimidine Metabolism","DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]","beta-alanine biosynthetic process; CMP catabolic process; dCMP catabolic process; dUMP catabolic process; nucleobase-containing small molecule metabolic process; purine nucleobase catabolic process; pyrimidine nucleobase catabolic process; thymidine catabolic process; thymine catabolic process; UMP catabolic process; uracil catabolic process","4 iron, 4 sulfur cluster binding; dihydropyrimidine dehydrogenase (NADP+) activity; flavin adenine dinucleotide binding; iron-sulfur cluster binding; metal ion binding; NADP binding; nucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors; protein binding; protein homodimerization activity; uracil binding","cytoplasm; cytosol","DNA damage","dihydropyrimidine dehydrogenase","http://www.ncbi.nlm.nih.gov/gene/?term=1806","1806","99586",null,null,null,null,"Q12882","Q8CHR6","A0A0G2K355","A0A8P0NLI5","A0A286ZUI1","A0A1D5QCM1","GO:0005737; GO:0005829","GO:0051539; GO:0017113; GO:0050660; GO:0051536; GO:0046872; GO:0050661; GO:0000166; GO:0016491; GO:0016627; GO:0005515; GO:0042803; GO:0002058","GO:0019483; GO:0006248; GO:0006249; GO:0046079; GO:0055086; GO:0006145; GO:0006208; GO:0006214; GO:0006210; GO:0046050; GO:0006212","PTHR43073:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3012|UniProtKB=Q12882","P02771"]
["DKK1",null,"DKK1","29","rb",null,2,5,"n/a","n/a","n/a","n/a","# 1593",".ALZ., .APO., .BMP., .CD., .CSP., .DEV., .DI., .MAPK., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.",null,"DICKKOPF-RELATED PROTEIN 1","canonical Wnt signaling pathway; cell morphogenesis involved in differentiation; embryonic limb morphogenesis; endocardial cushion development; endoderm development; endoderm formation; face morphogenesis; forebrain development; hair follicle development; head morphogenesis; heart valve development; learning or memory; limb development; mesoderm formation; motor learning; negative regulation of apoptotic process; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; negative regulation of cardiac muscle cell differentiation; negative regulation of mesodermal cell fate specification; negative regulation of neuron projection development; negative regulation of ossification; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of peptidyl-serine phosphorylation; negative regulation of presynapse assembly; negative regulation of protein binding; negative regulation of signaling receptor activity; negative regulation of transcription by RNA polymerase II; negative regulation of Wnt signaling pathway; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly; positive regulation of cell death; positive regulation of gene expression; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; positive regulation of JUN kinase activity; positive regulation of midbrain dopaminergic neuron differentiation; positive regulation of neuron death; positive regulation of tau-protein kinase activity; positive regulation of Wnt signaling pathway, calcium modulating pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; regulation of dopaminergic neuron differentiation; regulation of endodermal cell fate specification; regulation of receptor internalization; regulation of synapse organization; regulation of synaptic transmission, glutamatergic; regulation of Wnt signaling pathway; response to retinoic acid; synapse pruning; Wnt signaling pathway; Wnt signaling pathway involved in somitogenesis","co-receptor binding; growth factor activity; low-density lipoprotein particle receptor binding; protein binding; receptor antagonist activity","early endosome membrane; extracellular region; extracellular space; plasma membrane","Development","dickkopf WNT signaling pathway inhibitor 1","http://www.ncbi.nlm.nih.gov/gene/?term=22943","22943","13380","293897",null,null,"702997","O94907","O54908","D3Z9J1","A0A8I3Q0P4","F1SD03","F7G3K1","GO:0031901; GO:0005576; GO:0005615; GO:0005886","GO:0039706; GO:0008083; GO:0050750; GO:0005515; GO:0048019","GO:0060070; GO:0000904; GO:0030326; GO:0003197; GO:0007492; GO:0001706; GO:0060325; GO:0030900; GO:0001942; GO:0060323; GO:0003170; GO:0007611; GO:0060173; GO:0001707; GO:0061743; GO:0043066; GO:0030514; GO:0090090; GO:1901296; GO:2000726; GO:0042662; GO:0010977; GO:0030279; GO:0060394; GO:0033137; GO:1905607; GO:0032091; GO:2000272; GO:0000122; GO:0030178; GO:1904723; GO:0010942; GO:0010628; GO:0090082; GO:0043507; GO:1904958; GO:1901216; GO:1902949; GO:0045813; GO:2000096; GO:1904338; GO:0042663; GO:0002090; GO:0050807; GO:0051966; GO:0030111; GO:0032526; GO:0098883; GO:0016055; GO:0090244","PTHR12113:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2891|UniProtKB=O94907"]
["DKK1",null,"DKK1","29","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1594",".ALZ., .APO., .BMP., .CD., .CSP., .DEV., .DI., .MAPK., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.",null,"DICKKOPF-RELATED PROTEIN 1","canonical Wnt signaling pathway; cell morphogenesis involved in differentiation; embryonic limb morphogenesis; endocardial cushion development; endoderm development; endoderm formation; face morphogenesis; forebrain development; hair follicle development; head morphogenesis; heart valve development; learning or memory; limb development; mesoderm formation; motor learning; negative regulation of apoptotic process; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; negative regulation of cardiac muscle cell differentiation; negative regulation of mesodermal cell fate specification; negative regulation of neuron projection development; negative regulation of ossification; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of peptidyl-serine phosphorylation; negative regulation of presynapse assembly; negative regulation of protein binding; negative regulation of signaling receptor activity; negative regulation of transcription by RNA polymerase II; negative regulation of Wnt signaling pathway; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly; positive regulation of cell death; positive regulation of gene expression; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; positive regulation of JUN kinase activity; positive regulation of midbrain dopaminergic neuron differentiation; positive regulation of neuron death; positive regulation of tau-protein kinase activity; positive regulation of Wnt signaling pathway, calcium modulating pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; regulation of dopaminergic neuron differentiation; regulation of endodermal cell fate specification; regulation of receptor internalization; regulation of synapse organization; regulation of synaptic transmission, glutamatergic; regulation of Wnt signaling pathway; response to retinoic acid; synapse pruning; Wnt signaling pathway; Wnt signaling pathway involved in somitogenesis","co-receptor binding; growth factor activity; low-density lipoprotein particle receptor binding; protein binding; receptor antagonist activity","early endosome membrane; extracellular region; extracellular space; plasma membrane","Development","dickkopf WNT signaling pathway inhibitor 1","http://www.ncbi.nlm.nih.gov/gene/?term=22943","22943","13380","293897",null,null,"702997","O94907","O54908","D3Z9J1","A0A8I3Q0P4","F1SD03","F7G3K1","GO:0031901; GO:0005576; GO:0005615; GO:0005886","GO:0039706; GO:0008083; GO:0050750; GO:0005515; GO:0048019","GO:0060070; GO:0000904; GO:0030326; GO:0003197; GO:0007492; GO:0001706; GO:0060325; GO:0030900; GO:0001942; GO:0060323; GO:0003170; GO:0007611; GO:0060173; GO:0001707; GO:0061743; GO:0043066; GO:0030514; GO:0090090; GO:1901296; GO:2000726; GO:0042662; GO:0010977; GO:0030279; GO:0060394; GO:0033137; GO:1905607; GO:0032091; GO:2000272; GO:0000122; GO:0030178; GO:1904723; GO:0010942; GO:0010628; GO:0090082; GO:0043507; GO:1904958; GO:1901216; GO:1902949; GO:0045813; GO:2000096; GO:1904338; GO:0042663; GO:0002090; GO:0050807; GO:0051966; GO:0030111; GO:0032526; GO:0098883; GO:0016055; GO:0090244","PTHR12113:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2891|UniProtKB=O94907"]
["DKK2",null,"DKK2","32, 28","rb",null,6,4,"n/a","n/a","n/a","n/a","# 1522",".ALZ., .CSP., .DEV., .DI., .OP., .OPA., .ST., .WNT.",null,"DICKKOPF-RELATED PROTEIN 2","negative regulation of canonical Wnt signaling pathway; negative regulation of signaling receptor activity; negative regulation of Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; Wnt signaling pathway","co-receptor binding; protein binding; receptor antagonist activity","extracellular region; extracellular space","Development","dickkopf WNT signaling pathway inhibitor 2","http://www.ncbi.nlm.nih.gov/gene/?term=27123","27123","56811","295445",null,null,null,"Q9UBU2","Q9QYZ8","D3ZN48",null,null,null,"GO:0005576; GO:0005615","GO:0039706; GO:0005515; GO:0048019","GO:0090090; GO:2000272; GO:0030178; GO:0090263; GO:0016055","PTHR12113:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2892|UniProtKB=Q9UBU2"]
["DLL1",null,"DLL1","82","rb",null,7,4,2,1,2.1,1,"# 1433",".ANG., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .NOTCH., .OP., .OPA., .OT., .RTK., .ST., .TCD., .TMAT., .TRASR., .VEGFS.","Notch signaling pathway; Angiogenesis","DELTA-LIKE PROTEIN 1","astrocyte development; cell communication; cell differentiation; cell fate determination; cell-cell signaling; cerebellar molecular layer formation; cerebellar Purkinje cell layer structural organization; clathrin-dependent endocytosis; compartment pattern specification; determination of left/right symmetry; developmental process; endothelial tip cell fate specification; energy homeostasis; heart looping; hemopoiesis; inhibition of neuroepithelial cell differentiation; inner ear auditory receptor cell differentiation; inner ear development; lateral inhibition; left/right axis specification; loop of Henle development; marginal zone B cell differentiation; myeloid cell differentiation; negative regulation of cardiac muscle cell differentiation; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of epidermal cell differentiation; negative regulation of epithelial cell differentiation; negative regulation of glial cell apoptotic process; negative regulation of hemocyte differentiation; negative regulation of inner ear auditory receptor cell differentiation; negative regulation of interleukin-10 production; negative regulation of myeloid cell differentiation; negative regulation of myoblast differentiation; negative regulation of neuron differentiation; negative regulation of Notch signaling pathway; nephron development; neuroepithelial cell differentiation; neuron differentiation; neuron fate specification; neuronal stem cell population maintenance; Notch signaling pathway; Notch signaling pathway involved in arterial endothelial cell fate commitment; organ growth; positive regulation of cell population proliferation; positive regulation of endocytosis; positive regulation of gene expression; positive regulation of Notch signaling pathway; positive regulation of skeletal muscle tissue growth; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; proximal tubule development; proximal/distal pattern formation; regulation of blood pressure; regulation of cell adhesion; regulation of cell division; regulation of growth; regulation of neurogenesis; regulation of skeletal muscle tissue growth; regulation of somitogenesis; regulation of vascular endothelial growth factor signaling pathway; retina development in camera-type eye; retina morphogenesis in camera-type eye; skeletal muscle tissue growth; skin epidermis development; somite specification; somitogenesis; spinal cord development; type B pancreatic cell development","calcium ion binding; Notch binding; protein binding; receptor ligand activity; scaffold protein binding; Tat protein binding","adherens junction; anchoring junction; apical plasma membrane; cytoplasmic vesicle; extracellular region; membrane; membrane raft; plasma membrane","Development","delta like canonical Notch ligand 1","http://www.ncbi.nlm.nih.gov/gene/?term=28514","28514","13388",null,null,"100620481","714731","O00548","Q61483","A0A8I6A9U8","A0A8P0N6W7","I3LNT3","F7HB47","GO:0005912; GO:0070161; GO:0016324; GO:0031410; GO:0005576; GO:0016020; GO:0045121; GO:0005886","GO:0005509; GO:0005112; GO:0005515; GO:0048018; GO:0097110; GO:0030957","GO:0014002; GO:0007154; GO:0030154; GO:0001709; GO:0007267; GO:0021688; GO:0021693; GO:0072583; GO:0007386; GO:0007368; GO:0032502; GO:0097102; GO:0097009; GO:0001947; GO:0030097; GO:0002085; GO:0042491; GO:0048839; GO:0046331; GO:0070986; GO:0072070; GO:0002315; GO:0030099; GO:2000726; GO:0045596; GO:0008285; GO:0045605; GO:0030857; GO:0034351; GO:0045611; GO:0045608; GO:0032693; GO:0045638; GO:0045662; GO:0045665; GO:0045746; GO:0072006; GO:0060563; GO:0030182; GO:0048665; GO:0097150; GO:0007219; GO:0060853; GO:0035265; GO:0008284; GO:0045807; GO:0010628; GO:0045747; GO:0048633; GO:1903672; GO:0045944; GO:0072014; GO:0009954; GO:0008217; GO:0030155; GO:0051302; GO:0040008; GO:0050767; GO:0048631; GO:0014807; GO:1900746; GO:0060041; GO:0060042; GO:0048630; GO:0098773; GO:0001757; GO:0001756; GO:0021510; GO:0003323","PTHR24044:SF380","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2908|UniProtKB=O00548","P00045; P00005"]
["DLL3",null,"DLL3","65","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1432",".ANG., .BRC., .CANCER., .CANPTHW., .CSP., .DEV., .NOTCH., .OP., .TCD., .TMAT.","Notch signaling pathway; Angiogenesis","DELTA-LIKE PROTEIN 3","cell differentiation; compartment pattern specification; developmental process; negative regulation of neurogenesis; Notch signaling pathway; paraxial mesoderm development; skeletal system development; somitogenesis; tissue development","calcium ion binding; Notch binding","membrane","Development","delta like canonical Notch ligand 3","http://www.ncbi.nlm.nih.gov/gene/?term=10683","10683","13389",null,null,null,null,"Q9NYJ7","O88516","F1M9P5",null,"A0A480YVK2","F6TFV4","GO:0016020","GO:0005509; GO:0005112","GO:0030154; GO:0007386; GO:0032502; GO:0050768; GO:0007219; GO:0048339; GO:0001501; GO:0001756; GO:0009888","PTHR24044:SF308","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2909|UniProtKB=Q9NYJ7","P00045; P00005"]
["DLL4",null,"DLL4","80-75","rb",null,6,4,"n/a","n/a","n/a","n/a","# 1430",".ANG., .BRC., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .DEV., .IMUF., .NOTCH., .OP., .OPA., .OT., .ST., .TCD., .TCR., .TMAT., .TRASR.","Notch signaling pathway; Angiogenesis","DELTA-LIKE PROTEIN 4","angiogenesis; aortic valve morphogenesis; blood circulation; blood vessel lumenization; blood vessel remodeling; branching involved in blood vessel morphogenesis; cardiac atrium morphogenesis; cardiac ventricle morphogenesis; cell communication; cell differentiation; cellular response to fibroblast growth factor stimulus; cellular response to vascular endothelial growth factor stimulus; developmental process; dorsal aorta morphogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of endothelial cell migration; negative regulation of gene expression; negative regulation of Notch signaling pathway; negative regulation of transcription by RNA polymerase II; nervous system development; Notch signaling involved in heart development; Notch signaling pathway; pericardium morphogenesis; positive regulation of gene expression; positive regulation of neural precursor cell proliferation; positive regulation of Notch signaling pathway; regulation of neural retina development; regulation of neurogenesis; response to stimulus; signal transduction; T cell differentiation; ventral spinal cord interneuron fate commitment; ventricular trabecula myocardium morphogenesis; visual perception","calcium ion binding; Notch binding; protein binding; receptor ligand activity","membrane; plasma membrane","Development","delta like canonical Notch ligand 4","http://www.ncbi.nlm.nih.gov/gene/?term=54567","54567","54485","311332",null,null,null,"Q9NR61","Q9JI71","D3ZHH1","A0A8I3Q0Q1","A0A287AJ00","A0A5F7ZN66","GO:0016020; GO:0005886","GO:0005509; GO:0005112; GO:0005515; GO:0048018","GO:0001525; GO:0003180; GO:0008015; GO:0072554; GO:0001974; GO:0001569; GO:0003209; GO:0003208; GO:0007154; GO:0030154; GO:0044344; GO:0035924; GO:0032502; GO:0035912; GO:0043537; GO:1903588; GO:0090051; GO:0008285; GO:0010596; GO:0010629; GO:0045746; GO:0000122; GO:0007399; GO:0061314; GO:0007219; GO:0003344; GO:0010628; GO:2000179; GO:0045747; GO:0061074; GO:0050767; GO:0050896; GO:0007165; GO:0030217; GO:0060579; GO:0003222; GO:0007601","PTHR24044:SF320","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2910|UniProtKB=Q9NR61","P00045; P00005"]
["DNA polymerase beta",null,"POLB","38","rb",null,1,1,1,1,1,1,"# 1399",".APO., .CD., .CSP., .DDR., .DREP., .DRR., .IMFR., .IMUR., .OP., .OT.",null,"DNA POLYMERASE BETA","aging; apoptotic process; base-excision repair; base-excision repair, gap-filling; cellular response to DNA damage stimulus; DNA biosynthetic process; DNA metabolic process; DNA repair; DNA replication; DNA-templated DNA replication; double-strand break repair via nonhomologous end joining; homeostasis of number of cells; immunoglobulin heavy chain V-D-J recombination; in utero embryonic development; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; lymph node development; neuron apoptotic process; nucleotide-excision repair, DNA gap filling; pyrimidine dimer repair; response to ethanol; response to gamma radiation; response to hyperoxia; salivary gland morphogenesis; somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes; spleen development","damaged DNA binding; DNA binding; DNA polymerase activity; DNA-(apurinic or apyrimidinic site) endonuclease activity; DNA-directed DNA polymerase activity; enzyme binding; lyase activity; metal ion binding; microtubule binding; nucleotidyltransferase activity; protein binding; transferase activity","cytoplasm; microtubule; nucleoplasm; nucleus; protein-containing complex; spindle microtubule","DNA damage","DNA polymerase beta","http://www.ncbi.nlm.nih.gov/gene/?term=5423","5423","18970","29240","494001",null,null,"P06746","Q8K409","P06766","A0A8I3NDB6","A0A286ZNU0",null,"GO:0005737; GO:0005874; GO:0005654; GO:0005634; GO:0032991; GO:0005876","GO:0003684; GO:0003677; GO:0034061; GO:0003906; GO:0003887; GO:0019899; GO:0016829; GO:0046872; GO:0008017; GO:0016779; GO:0005515; GO:0016740","GO:0007568; GO:0006915; GO:0006284; GO:0006287; GO:0006974; GO:0071897; GO:0006259; GO:0006281; GO:0006260; GO:0006261; GO:0006303; GO:0048872; GO:0071707; GO:0001701; GO:0006954; GO:0008630; GO:0048535; GO:0051402; GO:0006297; GO:0006290; GO:0045471; GO:0010332; GO:0055093; GO:0007435; GO:0016445; GO:0016446; GO:0048536","PTHR11276:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9174|UniProtKB=P06746"]
["DNA-PK",null,"PRKDC","450","rb",null,2,4,4,4,4,4,"# 1372",".APO., .BCR., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .IIR., .IMU., .IMUF., .IMUR., .INS., .OP., .OPA., .OT., .SREME., .ST., .TCD., .TCR., .TMAT., .TRASR.",null,"DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT","activation of innate immune response; B cell lineage commitment; brain development; cellular response to DNA damage stimulus; cellular response to insulin stimulus; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via alternative nonhomologous end joining; double-strand break repair via nonhomologous end joining; ectopic germ cell programmed cell death; heart development; immature B cell differentiation; immune system process; immunoglobulin V(D)J recombination; innate immune response; intrinsic apoptotic signaling pathway in response to DNA damage; lymphocyte differentiation; maturation of 5.8S rRNA; mitotic G1 DNA damage checkpoint signaling; negative regulation of apoptotic process; negative regulation of protein phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of double-strand break repair via nonhomologous end joining; positive regulation of erythrocyte differentiation; positive regulation of lymphocyte differentiation; positive regulation of platelet formation; positive regulation of response to stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of translation; pro-B cell differentiation; protein destabilization; protein modification process; protein phosphorylation; regulation of cellular response to stress; regulation of circadian rhythm; regulation of epithelial cell proliferation; regulation of hematopoietic stem cell differentiation; regulation of nucleobase-containing compound metabolic process; regulation of smooth muscle cell proliferation; response to gamma radiation; response to ionizing radiation; rhythmic process; ribosome biogenesis; small-subunit processome assembly; somitogenesis; T cell differentiation in thymus; T cell lineage commitment; T cell receptor V(D)J recombination; telomere capping; telomere maintenance; V(D)J recombination","ATP binding; DNA binding; DNA-dependent protein kinase activity; double-stranded DNA binding; enzyme binding; kinase activity; nucleotide binding; protein binding; protein domain specific binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transferase activity; U3 snoRNA binding","chromosome, telomeric region; cytosol; DNA-dependent protein kinase complex; DNA-dependent protein kinase-DNA ligase 4 complex; membrane; nonhomologous end joining complex; nucleolus; nucleoplasm; nucleus; protein-containing complex; protein-DNA complex; small-subunit processome; transcription regulator complex","DNA damage","protein kinase, DNA-activated, catalytic subunit","http://www.ncbi.nlm.nih.gov/gene/?term=5591","5591","19090",null,null,null,"708029","P78527","P97313","A0A8I5ZT26","A0A8P0SBY5","A0A287A9N9","F6SNY4","GO:0000781; GO:0005829; GO:0070418; GO:0005958; GO:0016020; GO:0070419; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0032993; GO:0032040; GO:0005667","GO:0005524; GO:0003677; GO:0004677; GO:0003690; GO:0019899; GO:0016301; GO:0000166; GO:0005515; GO:0019904; GO:0004672; GO:0106310; GO:0004674; GO:0003723; GO:0061629; GO:0016740; GO:0034511","GO:0002218; GO:0002326; GO:0007420; GO:0006974; GO:0032869; GO:0006310; GO:0006281; GO:0006302; GO:0097681; GO:0006303; GO:0035234; GO:0007507; GO:0002327; GO:0002376; GO:0033152; GO:0045087; GO:0008630; GO:0030098; GO:0000460; GO:0031571; GO:0043066; GO:0001933; GO:0018105; GO:0018107; GO:0016310; GO:0043065; GO:2001034; GO:0045648; GO:0045621; GO:1905221; GO:0048584; GO:0045944; GO:0045727; GO:0002328; GO:0031648; GO:0036211; GO:0006468; GO:0080135; GO:0042752; GO:0050678; GO:1902036; GO:0019219; GO:0048660; GO:0010332; GO:0010212; GO:0048511; GO:0042254; GO:0034462; GO:0001756; GO:0033077; GO:0002360; GO:0033153; GO:0016233; GO:0000723; GO:0033151","PTHR11139:SF68","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9413|UniProtKB=P78527"]
["DNMT1",null,"DNMT1","200","rb",null,1,4,4,4,4,4,"# 1066",".CCP., .CP., .OP., .OT., .TRASR.",null,"DNA (CYTOSINE-5)-METHYLTRANSFERASE 1","C-5 methylation of cytosine; cellular response to amino acid stimulus; cellular response to bisphenol A; chromatin organization; DNA methylation; DNA methylation involved in embryo development; DNA methylation on cytosine; DNA methylation-dependent heterochromatin formation; DNA-templated transcription; maintenance of DNA methylation; methylation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; negative regulation of vascular associated smooth muscle cell apoptotic process; negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching; positive regulation of DNA methylation-dependent heterochromatin formation; positive regulation of gene expression; positive regulation of vascular associated smooth muscle cell proliferation; regulation of cell population proliferation; regulation of gene expression","chromatin binding; DNA (cytosine-5-)-methyltransferase activity; DNA binding; DNA-methyltransferase activity; metal ion binding; methyl-CpG binding; methyltransferase activity; promoter-specific chromatin binding; protein binding; RNA binding; transferase activity; zinc ion binding","female germ cell nucleus; germ cell nucleus; heterochromatin; nucleoplasm; nucleus; pericentric heterochromatin; replication fork",null,"DNA methyltransferase 1","http://www.ncbi.nlm.nih.gov/gene/?term=1786","1786","13433","84350",null,null,null,"P26358","P13864","F1LQT9","A0A8I3NUZ2","A0A287A8G0","A0A1D5RKS1","GO:0001674; GO:0043073; GO:0000792; GO:0005654; GO:0005634; GO:0005721; GO:0005657","GO:0003682; GO:0003886; GO:0003677; GO:0009008; GO:0046872; GO:0008327; GO:0008168; GO:1990841; GO:0005515; GO:0003723; GO:0016740; GO:0008270","GO:0090116; GO:0071230; GO:1903926; GO:0006325; GO:0006306; GO:0043045; GO:0032776; GO:0006346; GO:0006351; GO:0010216; GO:0032259; GO:0045892; GO:0010629; GO:0000122; GO:1905460; GO:1905931; GO:0090309; GO:0010628; GO:1904707; GO:0042127; GO:0010468","PTHR10629:SF52","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2976|UniProtKB=P26358"]
["DNMT3L",null,"DNMT3L","49","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1702",".OP., .OT., .TRASR.",null,"DNA (CYTOSINE-5)-METHYLTRANSFERASE 3-LIKE","C-5 methylation of cytosine; cell differentiation; chorionic trophoblast cell differentiation; DNA metabolic process; DNA methylation; DNA methylation involved in gamete generation; DNA methylation on cytosine; genomic imprinting; in utero embryonic development; male meiosis I; methylation; negative regulation of DNA methylation; negative regulation of DNA-templated transcription; negative regulation of transposition; placenta development; positive regulation of DNA methylation; regulation of gene expression; regulation of gene expression by genomic imprinting; spermatogenesis; stem cell differentiation","enzyme activator activity; enzyme binding; metal ion binding; protein binding","catalytic complex; condensed nuclear chromosome; cytoplasm; cytosol; ESC/E(Z) complex; heterochromatin; nucleus",null,"DNA methyltransferase 3 like","http://www.ncbi.nlm.nih.gov/gene/?term=29947","29947","54427",null,null,null,"722184","Q9UJW3","Q9CWR8","A0A8I5ZPM6","A0A8I3NZX9","A0A287ALA8","F7BC47","GO:1902494; GO:0000794; GO:0005737; GO:0005829; GO:0035098; GO:0000792; GO:0005634","GO:0008047; GO:0019899; GO:0046872; GO:0005515","GO:0090116; GO:0030154; GO:0060718; GO:0006259; GO:0006306; GO:0043046; GO:0032776; GO:0071514; GO:0001701; GO:0007141; GO:0032259; GO:1905642; GO:0045892; GO:0010529; GO:0001890; GO:1905643; GO:0010468; GO:0006349; GO:0007283; GO:0048863","PTHR23068:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2980|UniProtKB=Q9UJW3"]
["DPP3 (Dipeptidyl-peptidase 3)",null,"DPP3","83","rb",null,2,6,6,6,6,6,"# 0721",null,null,"DIPEPTIDYL PEPTIDASE 3","protein catabolic process; proteolysis","aminopeptidase activity; dipeptidyl-peptidase activity; hydrolase activity; metal ion binding; metalloexopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding","cytoplasm; cytosol; extracellular exosome",null,"dipeptidyl peptidase 3","http://www.ncbi.nlm.nih.gov/gene/?term=10072","10072","75221","114591",null,null,null,"Q9NY33","Q99KK7","O55096","A0A8P0NRM3","A0A5G2RH47","A0A1D5QHJ3","GO:0005737; GO:0005829; GO:0070062","GO:0004177; GO:0008239; GO:0016787; GO:0046872; GO:0008235; GO:0008237; GO:0008233; GO:0005515; GO:0008270","GO:0030163; GO:0006508","PTHR23422:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3008|UniProtKB=Q9NY33"]
["DRAK2",null,"STK17B","43","rb",null,4,1,2,1,1,1,"# 1147",".APO., .CD., .CSP., .OPA., .ST.",null,"SERINE/THREONINE-PROTEIN KINASE 17B","apoptotic process; intracellular signal transduction; phosphorylation; positive regulation of apoptotic process; positive regulation of fibroblast apoptotic process; programmed cell death; protein autophosphorylation; protein phosphorylation","ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","actin cytoskeleton; endoplasmic reticulum-Golgi intermediate compartment; membrane; nucleus; plasma membrane","Apoptosis","serine/threonine kinase 17b","http://www.ncbi.nlm.nih.gov/gene/?term=9262","9262","98267","170904",null,null,null,"O94768","Q8BG48","Q91XS8","A0A8I3S318","A0A480DMB9",null,"GO:0015629; GO:0005793; GO:0016020; GO:0005634; GO:0005886","GO:0005524; GO:0016301; GO:0000166; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:0035556; GO:0016310; GO:0043065; GO:2000271; GO:0012501; GO:0046777; GO:0006468","PTHR24342:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11396|UniProtKB=O94768"]
["DUSP1 (MKP1)",null,"DUSP1","42","rb",null,2,2,2,2,6,2,"# 2124",".CCP., .CCY., .CP., .CSP., .IMUR., .LMIG., .MAPK., .OP., .OPA., .OXS., .P38., .RTK., .SREME., .ST.","p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 1","cell cycle; cellular response to chemokine; dephosphorylation; endoderm formation; negative regulation of cell adhesion; negative regulation of cell population proliferation; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of meiotic cell cycle; negative regulation of monocyte chemotaxis; negative regulation of p38MAPK cascade; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; regulation of mitotic cell cycle spindle assembly checkpoint","hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; nucleus","MAPK signaling","dual specificity phosphatase 1","http://www.ncbi.nlm.nih.gov/gene/?term=1843","1843","19252",null,null,null,null,"P28562","P28563",null,"A0A8I3MDC3","K7GSI5",null,"GO:0005737; GO:0005634","GO:0016787; GO:0017017; GO:0051019; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0007049; GO:1990869; GO:0016311; GO:0001706; GO:0007162; GO:0008285; GO:0043407; GO:0043409; GO:0051447; GO:0090027; GO:1903753; GO:0070262; GO:0035970; GO:0035335; GO:0006470; GO:0090266","PTHR10159:SF309","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3064|UniProtKB=P28562","P05918; P06664; P00046"]
["DUSP1 (MKP1) - phospho","Ser296/Ser318","DUSP1","39","rb",null,6,7,"n/a","n/a","n/a","n/a","# 0393",".CCP., .CCY., .CP., .CSP., .IMUR., .LMIG., .MAPK., .OP., .OPA., .OXS., .P38., .RTK., .SREME., .ST.","p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 1","cell cycle; cellular response to chemokine; dephosphorylation; endoderm formation; negative regulation of cell adhesion; negative regulation of cell population proliferation; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of meiotic cell cycle; negative regulation of monocyte chemotaxis; negative regulation of p38MAPK cascade; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; regulation of mitotic cell cycle spindle assembly checkpoint","hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; nucleus","MAPK signaling","dual specificity phosphatase 1","http://www.ncbi.nlm.nih.gov/gene/?term=1843","1843","19252",null,null,null,null,"P28562","P28563",null,"A0A8I3MDC3","K7GSI5",null,"GO:0005737; GO:0005634","GO:0016787; GO:0017017; GO:0051019; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0007049; GO:1990869; GO:0016311; GO:0001706; GO:0007162; GO:0008285; GO:0043407; GO:0043409; GO:0051447; GO:0090027; GO:1903753; GO:0070262; GO:0035970; GO:0035335; GO:0006470; GO:0090266","PTHR10159:SF309","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3064|UniProtKB=P28562","P05918; P06664; P00046"]
["DUSP1 (MKP1) - phospho","Ser359","DUSP1","40","rb",null,6,5,"n/a","n/a","n/a","n/a","# 2065",".CCP., .CCY., .CP., .CSP., .IMUR., .LMIG., .MAPK., .OP., .OPA., .OXS., .P38., .RTK., .SREME., .ST.","p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 1","cell cycle; cellular response to chemokine; dephosphorylation; endoderm formation; negative regulation of cell adhesion; negative regulation of cell population proliferation; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of meiotic cell cycle; negative regulation of monocyte chemotaxis; negative regulation of p38MAPK cascade; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; regulation of mitotic cell cycle spindle assembly checkpoint","hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; nucleus","MAPK signaling","dual specificity phosphatase 1","http://www.ncbi.nlm.nih.gov/gene/?term=1843","1843","19252",null,null,null,null,"P28562","P28563",null,"A0A8I3MDC3","K7GSI5",null,"GO:0005737; GO:0005634","GO:0016787; GO:0017017; GO:0051019; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0007049; GO:1990869; GO:0016311; GO:0001706; GO:0007162; GO:0008285; GO:0043407; GO:0043409; GO:0051447; GO:0090027; GO:1903753; GO:0070262; GO:0035970; GO:0035335; GO:0006470; GO:0090266","PTHR10159:SF309","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3064|UniProtKB=P28562","P05918; P06664; P00046"]
["DUSP10 (MKP-5)",null,"DUSP10","54","rb",null,7,1.1000000000000001,"n/a","n/a","n/a","n/a","# 0406",".CCP., .CP., .CSP., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .P38., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT.","p38 MAPK pathway; Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 10","dephosphorylation; negative regulation of cell migration; negative regulation of epithelial cell migration; negative regulation of epithelial cell proliferation; negative regulation of epithelium regeneration; negative regulation of ERK1 and ERK2 cascade; negative regulation of JNK cascade; negative regulation of JUN kinase activity; negative regulation of MAPK cascade; negative regulation of oligodendrocyte differentiation; negative regulation of p38MAPK cascade; negative regulation of protein kinase activity by regulation of protein phosphorylation; negative regulation of respiratory burst involved in inflammatory response; negative regulation of stress-activated MAPK cascade; oligodendrocyte differentiation; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; positive regulation of regulatory T cell differentiation; protein dephosphorylation; regulation of adaptive immune response; regulation of brown fat cell differentiation; regulation of innate immune response; response to lipopolysaccharide; response to organic substance","hydrolase activity; JUN kinase binding; MAP kinase phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase p38 binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; cytosol; Golgi apparatus; nuclear speck; nucleoplasm; nucleus","MAPK signaling","dual specificity phosphatase 10","http://www.ncbi.nlm.nih.gov/gene/?term=11221","11221","63953","63995",null,"100517416","705056","Q9Y6W6","Q9ESS0","D3ZBG7","A0A8P0SIH2","F1S9I4","F7FRL4","GO:0005737; GO:0005829; GO:0005794; GO:0016607; GO:0005654; GO:0005634","GO:0016787; GO:0008432; GO:0033549; GO:0017017; GO:0048273; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0016311; GO:0030336; GO:0010633; GO:0050680; GO:1905042; GO:0070373; GO:0046329; GO:0043508; GO:0043409; GO:0048715; GO:1903753; GO:0044387; GO:0060266; GO:0032873; GO:0048709; GO:0035970; GO:1990264; GO:0045591; GO:0006470; GO:0002819; GO:0090335; GO:0045088; GO:0032496; GO:0010033","PTHR10159:SF299","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3065|UniProtKB=Q9Y6W6","P05918; P00046"]
["DUSP14 (MKP6, MKP-6, MKP-L)",null,"DUSP14","22","rb",null,2,6,7,7,7,7,"# 0334",".CSP., .OPA., .OXS., .SREME., .ST.","Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 14","dephosphorylation; protein dephosphorylation","hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; RNA binding",null,"MAPK signaling","dual specificity phosphatase 14","http://www.ncbi.nlm.nih.gov/gene/?term=11072","11072","56405","365977","491131",null,"714383","O95147","Q9JLY7","M0R3K8","A0A8I3NI61","I3LNI4","F7GXT5",null,"GO:0016787; GO:0017017; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0003723","GO:0016311; GO:0006470","PTHR45961:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17007|UniProtKB=O95147","P00046"]
["DUSP16 (MKP-7)",null,"DUSP16","73","rb",null,2,2,2,6,2,2,"# 0391",".CSP., .JNK., .MAPK., .OPA., .OXS., .RTK., .SREME., .ST.","Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 16","dephosphorylation; MAPK export from nucleus; negative regulation of JUN kinase activity; negative regulation of MAPK cascade; protein dephosphorylation","hydrolase activity; JUN kinase binding; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding; mitogen-activated protein kinase p38 binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; cytoplasmic vesicle; cytosol; nucleoplasm; nucleus","MAPK signaling","dual specificity phosphatase 16","http://www.ncbi.nlm.nih.gov/gene/?term=80824","80824",null,"297682",null,null,null,"Q9BY84","A0A0N4SUV2","D4A3W6","A0A8I3PQ41",null,"F6YF90","GO:0005737; GO:0031410; GO:0005829; GO:0005654; GO:0005634","GO:0016787; GO:0008432; GO:0017017; GO:0051019; GO:0048273; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0016311; GO:0045204; GO:0043508; GO:0043409; GO:0006470","PTHR10159:SF343","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17909|UniProtKB=Q9BY84","P00046"]
["DUSP2 (PAC-1)",null,"DUSP2","34","gt",null,6,7,"n/a","n/a","n/a","n/a","# 0394",".CSP., .MAPK., .OPA., .OXS., .RTK., .SREME., .ST.","Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 2","dephosphorylation; endoderm formation; negative regulation of MAPK cascade; protein dephosphorylation","hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; nuclear membrane; nucleoplasm; nucleus","MAPK signaling","dual specificity phosphatase 2","http://www.ncbi.nlm.nih.gov/gene/?term=1844","1844","13537","311406",null,null,null,"Q05923","Q05922","Q5M863","A0A8I3N0J1",null,null,"GO:0005737; GO:0031965; GO:0005654; GO:0005634","GO:0016787; GO:0017017; GO:0051019; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0016311; GO:0001706; GO:0043409; GO:0006470","PTHR10159:SF109","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3068|UniProtKB=Q05923","P00046"]
["DUSP4",null,"DUSP4","44","rb",null,2,2,6,6,6,6,"# 1568",".CSP., .MAPK., .OPA., .OXS., .RTK., .SREME., .ST.","Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 4","dephosphorylation; endoderm formation; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAPK cascade; protein dephosphorylation","hydrolase activity; MAP kinase serine/threonine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; nucleoplasm; nucleus","MAPK signaling","dual specificity phosphatase 4","http://www.ncbi.nlm.nih.gov/gene/?term=1846","1846","319520",null,null,null,null,"Q13115","Q8BFV3","G3V7L2","A0A8I3NYF2","A0A286ZK12",null,"GO:0005737; GO:0005654; GO:0005634","GO:0016787; GO:1990439; GO:0017017; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0016311; GO:0001706; GO:0070373; GO:0043409; GO:0006470","PTHR10159:SF111","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3070|UniProtKB=Q13115","P00046"]
["DUSP5 (VH3)",null,"DUSP5","42","rb",null,6,2,2,6,2,6,"# 0417",".CSP., .MAPK., .OPA., .OXS., .RTK., .SREME., .ST.","Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 5","dephosphorylation; endoderm formation; ERK1 and ERK2 cascade; MAPK cascade; negative regulation of MAPK cascade; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation","hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; nucleoplasm; nucleus","MAPK signaling","dual specificity phosphatase 5","http://www.ncbi.nlm.nih.gov/gene/?term=1847","1847","240672",null,"486884",null,null,"Q16690","Q1HL35","F1LPJ5","A0A8I3Q097",null,null,"GO:0005737; GO:0005654; GO:0005634","GO:0016787; GO:0017017; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0016311; GO:0001706; GO:0070371; GO:0000165; GO:0043409; GO:0035970; GO:0035335; GO:0006470","PTHR10159:SF40","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3071|UniProtKB=Q16690","P00046"]
["DUSP6 (MKP3, MKP-3, PYST1)",null,"DUSP6","42","rb",null,2,1,1,8,8,2.1,"# 1754",".AML., .APO., .CANCER., .CD., .CSP., .DRR., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST.","Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 6","cell differentiation; dephosphorylation; ERK1 and ERK2 cascade; MAPK cascade; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAPK cascade; negative regulation of protein phosphorylation; peptidyl-tyrosine dephosphorylation; positive regulation of apoptotic process; positive regulation of cell death; protein dephosphorylation; regulation of heart growth; response to growth factor; response to nitrosative stress; response to organic cyclic compound; response to organic substance; response to xenobiotic stimulus","hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; cytosol; nucleoplasm","MAPK signaling","dual specificity phosphatase 6","http://www.ncbi.nlm.nih.gov/gene/?term=1848","1848","67603","116663","482594",null,null,"Q16828","Q9DBB1","Q64346","A0A8I3PEE7",null,null,"GO:0005737; GO:0005829; GO:0005654","GO:0016787; GO:0017017; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0030154; GO:0016311; GO:0070371; GO:0000165; GO:0070373; GO:0043409; GO:0001933; GO:0035335; GO:0043065; GO:0010942; GO:0006470; GO:0060420; GO:0070848; GO:0051409; GO:0014070; GO:0010033; GO:0009410","PTHR10159:SF45","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3072|UniProtKB=Q16828","P00046"]
["DUSP7 (PYST2)",null,"DUSP7","41","gt",null,7,7,"n/a","n/a","n/a","n/a","# 0497",".CSP., .MAPK., .OPA., .OXS., .RTK., .SREME., .ST.","Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 7","dephosphorylation; ERK1 and ERK2 cascade; MAPK cascade; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; peptidyl-tyrosine dephosphorylation; protein dephosphorylation","hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; cytosol; nucleoplasm","MAPK signaling","dual specificity phosphatase 7","http://www.ncbi.nlm.nih.gov/gene/?term=1849","1849","235584","300980",null,null,"698473","Q16829","Q91Z46","Q63340",null,null,"F7GK32","GO:0005737; GO:0005829; GO:0005654","GO:0016787; GO:0017017; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0016311; GO:0070371; GO:0000165; GO:0043407; GO:0043409; GO:0035335; GO:0006470","PTHR10159:SF305","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3073|UniProtKB=Q16829","P00046"]
["DUSP9 (MKP4, MKP-4)",null,"DUSP9","42","rb",null,2,2,2,6,2,6,"# 0337",".APO., .CD., .CSP., .JNK., .MAPK., .OPA., .OXS., .RTK., .SREME., .ST.","Oxidative stress response","DUAL SPECIFICITY PROTEIN PHOSPHATASE 9","dephosphorylation; ERK1 and ERK2 cascade; JNK cascade; MAPK cascade; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAPK cascade; positive regulation of apoptotic process; protein dephosphorylation; regulation of heart growth","hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity","cytoplasm; cytosol; nucleus","MAPK signaling","dual specificity phosphatase 9","http://www.ncbi.nlm.nih.gov/gene/?term=1852","1852","75590","293847",null,null,null,"Q99956","Q7TNL7","Q2YDV1","A0A8I3PP79",null,null,"GO:0005737; GO:0005829; GO:0005634","GO:0016787; GO:0017017; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:0008138; GO:0008330","GO:0016311; GO:0070371; GO:0007254; GO:0000165; GO:0070373; GO:0043409; GO:0043065; GO:0006470; GO:0060420","PTHR10159:SF388","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3076|UniProtKB=Q99956","P00046"]
["Dvl2",null,"DVL2","95-90","rb",null,2,1,8,8,8,8,"# 2464",".ALZ., .ANG., .BRC., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .CUR., .D300., .DEV., .DI., .DMTOR., .HIPPO., .MAPK., .MTOR., .NOTCH., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.","Alzheimer disease-presenilin pathway; Angiogenesis; Wnt signaling pathway","SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2","canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in regulation of cell proliferation; cochlea morphogenesis; convergent extension involved in neural plate elongation; convergent extension involved in organogenesis; heart development; heart looping; heart morphogenesis; intracellular signal transduction; neural tube closure; non-canonical Wnt signaling pathway; outflow tract morphogenesis; planar cell polarity pathway involved in neural tube closure; positive regulation of DNA-binding transcription factor activity; positive regulation of GTPase activity; positive regulation of JUN kinase activity; positive regulation of neuron projection arborization; positive regulation of protein phosphorylation; positive regulation of protein tyrosine kinase activity; positive regulation of transcription by RNA polymerase II; protein localization; regulation of anatomical structure morphogenesis; regulation of catalytic activity; regulation of DNA-templated transcription; segment specification; segmentation; Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway","frizzled binding; identical protein binding; protein binding; protein domain specific binding; protein kinase binding; protein self-association; protein-macromolecule adaptor activity; small GTPase binding","aggresome; apical part of cell; clathrin-coated endocytic vesicle; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytosol; lateral plasma membrane; membrane; nuclear body; nucleoplasm; nucleus; plasma membrane","Wnt signaling","dishevelled segment polarity protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=1856","1856","13543","303251","489464",null,null,"O14641","Q60838","D3ZB71","A0A8I3S1H6","A0A287AJQ6",null,"GO:0016235; GO:0045177; GO:0045334; GO:0030136; GO:0005737; GO:0031410; GO:0005829; GO:0016328; GO:0016020; GO:0016604; GO:0005654; GO:0005634; GO:0005886","GO:0005109; GO:0042802; GO:0005515; GO:0019904; GO:0019901; GO:0043621; GO:0030674; GO:0031267","GO:0060070; GO:0044340; GO:0090103; GO:0022007; GO:0060029; GO:0007507; GO:0001947; GO:0003007; GO:0035556; GO:0001843; GO:0035567; GO:0003151; GO:0090179; GO:0051091; GO:0043547; GO:0043507; GO:0150012; GO:0001934; GO:0061098; GO:0045944; GO:0008104; GO:0022603; GO:0050790; GO:0006355; GO:0007379; GO:0035282; GO:0016055; GO:0060071","PTHR10878:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3086|UniProtKB=O14641","P00004; P00005; P00057"]
["Dvl3",null,"DVL3","93-88","rb",null,2,2,8,8,8.1,8,"# 0686",".ALZ., .ANG., .BRC., .CANCER., .CANPTHW., .CSP., .CUR., .D300., .DEV., .DI., .DMTOR., .HIPPO., .MAPK., .MTOR., .NOTCH., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.","Alzheimer disease-presenilin pathway; Angiogenesis; Wnt signaling pathway","SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3","canonical Wnt signaling pathway; intracellular signal transduction; non-canonical Wnt signaling pathway; non-canonical Wnt signaling pathway via JNK cascade; planar cell polarity pathway involved in neural tube closure; positive regulation of DNA-templated transcription; positive regulation of GTPase activity; positive regulation of JUN kinase activity; positive regulation of neuron projection arborization; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein stabilization; regulation of anatomical structure morphogenesis; regulation of catalytic activity; regulation of protein localization; Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway","beta-catenin binding; frizzled binding; protease binding; protein binding; signaling receptor binding; small GTPase binding","chromatin; cytoplasm; cytosol","Wnt signaling","dishevelled segment polarity protein 3","http://www.ncbi.nlm.nih.gov/gene/?term=1857","1857","13544",null,"478650",null,null,"Q92997","Q61062","A0A8I6GKX7","A0A8I3PTY8","I3LNW9","F7HRY3","GO:0000785; GO:0005737; GO:0005829","GO:0008013; GO:0005109; GO:0002020; GO:0005515; GO:0005102; GO:0031267","GO:0060070; GO:0035556; GO:0035567; GO:0038031; GO:0090179; GO:0045893; GO:0043547; GO:0043507; GO:0150012; GO:0001934; GO:0045944; GO:0050821; GO:0022603; GO:0050790; GO:0032880; GO:0016055; GO:0060071","PTHR10878:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3087|UniProtKB=Q92997","P00004; P00005; P00057"]
["E2F-1",null,"E2F1","70","rb",null,7,3.1,"n/a","n/a","n/a","n/a","# 1106",".APH., .APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DDR., .DI., .DRR., .GLI., .HEPB., .HIF., .MEL., .NSCLC., .OP., .OT., .P53S., .PAC., .PRC., .SCLC., .SREME., .TRASR.",null,"TRANSCRIPTION FACTOR E2F1","anoikis; apoptotic process; cell cycle; cellular response to fatty acid; cellular response to hypoxia; cellular response to nerve growth factor stimulus; cellular response to xenobiotic stimulus; DNA damage checkpoint signaling; DNA-templated transcription; forebrain development; G1/S transition of mitotic cell cycle; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage; lens fiber cell apoptotic process; mRNA stabilization; negative regulation of DNA binding; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of DNA-templated transcription; regulation of G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; regulation of transcription involved in G1/S transition of mitotic cell cycle; spermatogenesis","cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; molecular adaptor activity; protein binding; protein dimerization activity; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","centrosome; chromatin; cytoplasm; nuclear chromosome; nucleoplasm; nucleus; protein-containing complex; Rb-E2F complex; RNA polymerase II transcription regulator complex; transcription regulator complex","Transcription factor","E2F transcription factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=1869","1869","13555",null,null,null,"714126","Q01094","Q61501","A0A0G2JWW3",null,"A0A480YVC5","F7DEJ9","GO:0005813; GO:0000785; GO:0005737; GO:0000228; GO:0005654; GO:0005634; GO:0032991; GO:0035189; GO:0090575; GO:0005667","GO:0000987; GO:0003677; GO:0001216; GO:0003700; GO:0000981; GO:0140297; GO:0060090; GO:0005515; GO:0046983; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0043276; GO:0006915; GO:0007049; GO:0071398; GO:0071456; GO:1990090; GO:0071466; GO:0000077; GO:0006351; GO:0030900; GO:0000082; GO:0072332; GO:0008630; GO:1990086; GO:0048255; GO:0043392; GO:0043433; GO:0045892; GO:0045599; GO:0070345; GO:0000122; GO:0071930; GO:0043065; GO:0045893; GO:0048146; GO:0010628; GO:0060252; GO:0045944; GO:0051726; GO:0006355; GO:2000045; GO:0006357; GO:0000083; GO:0007283","PTHR12081:SF43","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3113|UniProtKB=Q01094"]
["E2F-2",null,"E2F2","45-40","rb",null,2,2,7,6,6,6.1,"# 1107",".ANG., .APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CSP., .DI., .GLI., .HEPB., .MEL., .NSCLC., .OP., .OT., .P53S., .PAC., .PRC., .SCLC., .TRASR.",null,"TRANSCRIPTION FACTOR E2F2","cell cycle; intrinsic apoptotic signaling pathway by p53 class mediator; lens fiber cell apoptotic process; negative regulation of DNA-binding transcription factor activity; negative regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of transcription involved in G1/S transition of mitotic cell cycle; transcription initiation at RNA polymerase II promoter","cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; nucleoplasm; nucleus; Rb-E2F complex; RNA polymerase II transcription regulator complex; transcription regulator complex","Transcription factor","E2F transcription factor 2","http://www.ncbi.nlm.nih.gov/gene/?term=1870","1870","242705","684111","100855664",null,"710200","Q14209","P56931","M0RDX6","A0A8I3NKC8",null,"F7H757","GO:0000785; GO:0005654; GO:0005634; GO:0035189; GO:0090575; GO:0005667","GO:0000987; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0046983; GO:0000978; GO:0000977; GO:0043565; GO:1990837","GO:0007049; GO:0072332; GO:1990086; GO:0043433; GO:1903671; GO:0045944; GO:0051726; GO:0006355; GO:0006357; GO:0000083; GO:0006367","PTHR12081:SF50","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3114|UniProtKB=Q14209"]
["E2F-3",null,"E2F3","58","ms",null,1.1000000000000001,1.1000000000000001,"n/a","n/a","n/a","n/a","# 1108",".BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DI., .GLI., .HEPB., .MEL., .NSCLC., .OP., .OT., .P53S., .PAC., .PRC., .SCLC., .TRASR.","p53 pathway; Cell cycle; p53 pathway feedback loops 2","TRANSCRIPTION FACTOR E2F3","cell cycle; G1/S transition of mitotic cell cycle; negative regulation of fat cell proliferation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; positive regulation of vascular associated smooth muscle cell apoptotic process; protein import into nucleus; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; transcription initiation at RNA polymerase II promoter","cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex","Transcription factor","E2F transcription factor 3","http://www.ncbi.nlm.nih.gov/gene/?term=1871","1871","13557",null,null,null,null,"O00716","O35261","A0A0G2JTE8","A0A8I3NR69",null,"A0A1D5QDI9","GO:0000785; GO:0005654; GO:0005634; GO:0090575; GO:0005667","GO:0000987; GO:0003677; GO:0001216; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0046983; GO:0000978; GO:0000977; GO:0043565; GO:1990837","GO:0007049; GO:0000082; GO:0070345; GO:0008284; GO:0045893; GO:0045944; GO:1905461; GO:0006606; GO:0006355; GO:0006357; GO:0006367","PTHR12081:SF44","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3115|UniProtKB=O00716","P00059; P00013; P04398"]
["E2F-4",null,"E2F4","44","rb",null,1,2,2,2,2,2,"# 1131",".CCP., .CCY., .CP., .CSP., .DEV., .OP., .OT., .TGFB., .TRASR.",null,"TRANSCRIPTION FACTOR E2F4","animal organ morphogenesis; blood circulation; cell cycle; cell projection organization; cell volume homeostasis; centriole assembly; cilium assembly; epithelial cell development; motile cilium assembly; multi-ciliated epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of cell population proliferation; regulation of cell size; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of transcription involved in G1/S transition of mitotic cell cycle","chromatin binding; DNA binding; DNA-binding transcription activator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; promoter-specific chromatin binding; protein binding; protein dimerization activity; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; cytoplasm; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex","Transcription factor","E2F transcription factor 4","http://www.ncbi.nlm.nih.gov/gene/?term=1874","1874","104394","100360427","611243",null,null,"Q16254","Q8R0K9","D4A9V4","A0A8I3N364","A0A286ZZW3","A0A5F7ZX58","GO:0000785; GO:0005737; GO:0005654; GO:0005634; GO:0090575; GO:0005667","GO:0003682; GO:0003677; GO:0001216; GO:0001228; GO:0003700; GO:0000981; GO:1990841; GO:0005515; GO:0046983; GO:0019904; GO:0000978; GO:1990837","GO:0009887; GO:0008015; GO:0007049; GO:0030030; GO:0006884; GO:0098534; GO:0060271; GO:0002064; GO:0044458; GO:1903251; GO:0045944; GO:0042127; GO:0008361; GO:0006355; GO:0006357; GO:0000083","PTHR12081:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3118|UniProtKB=Q16254"]
["EB-1",null,"MAPRE1","30","ms",null,1,4,2,2,2,2,"# 1277",".CCP., .CCY., .CP., .MIG., .OP., .OT.",null,"MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER 1","attachment of mitotic spindle microtubules to kinetochore; cell cycle; cell division; cell migration; establishment of mitotic spindle orientation; microtubule bundle formation; microtubule polymerization; negative regulation of microtubule polymerization; non-motile cilium assembly; positive regulation of microtubule plus-end binding; positive regulation of microtubule polymerization; protein localization; protein localization to astral microtubule; protein localization to centrosome; protein localization to microtubule; regulation of microtubule polymerization or depolymerization; spindle assembly","cadherin binding; identical protein binding; microtubule binding; microtubule plus-end binding; molecular adaptor activity; protein binding; protein C-terminus binding; protein kinase binding; RNA binding","cell projection; cell projection membrane; centrosome; ciliary basal body; cortical microtubule cytoskeleton; cytoplasm; cytoplasmic microtubule; cytoskeleton; cytosol; focal adhesion; Golgi apparatus; microtubule; microtubule cytoskeleton; microtubule organizing center; microtubule plus-end; mitotic spindle astral microtubule end; mitotic spindle pole; spindle; spindle midzone; spindle pole","Cytoskeletal signaling","microtubule associated protein RP/EB family member 1","http://www.ncbi.nlm.nih.gov/gene/?term=22919","22919","13589",null,null,null,null,"Q15691","Q61166","A0A0G2JT48","A0A8P0SPR0","A0A286ZPA2",null,"GO:0042995; GO:0031253; GO:0005813; GO:0036064; GO:0030981; GO:0005737; GO:0005881; GO:0005856; GO:0005829; GO:0005925; GO:0005794; GO:0005874; GO:0015630; GO:0005815; GO:0035371; GO:1905721; GO:0097431; GO:0005819; GO:0051233; GO:0000922","GO:0045296; GO:0042802; GO:0008017; GO:0051010; GO:0060090; GO:0005515; GO:0008022; GO:0019901; GO:0003723","GO:0051315; GO:0007049; GO:0051301; GO:0016477; GO:0000132; GO:0001578; GO:0046785; GO:0031115; GO:1905515; GO:1903033; GO:0031116; GO:0008104; GO:1902888; GO:0071539; GO:0035372; GO:0031110; GO:0051225","PTHR10623:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6890|UniProtKB=Q15691"]
["E-Cadherin",null,"CDH1","135","gt",null,2,2,2,6,2.1,2.1,"# 0742",".ALZ., .BLC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CP., .CSP., .DEV., .DI., .DRR., .EMC., .HIPPO., .MEL., .MIG., .OP., .OPA., .OT., .TRASR., .TYR., .WNT.","CCKR signaling map; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Wnt signaling pathway","CADHERIN-1","adherens junction organization; cell adhesion; cell-cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; cellular response to indole-3-methanol; cellular response to lithium ion; homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of axon extension; negative regulation of cell migration; negative regulation of cell-cell adhesion; neuron projection development; pituitary gland development; positive regulation of DNA-templated transcription; positive regulation of protein import into nucleus; protein localization to plasma membrane; regulation of gene expression; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; response to Gram-positive bacterium; response to organic substance; response to toxic substance; response to xenobiotic stimulus; synapse assembly","ankyrin binding; beta-catenin binding; cadherin binding; calcium ion binding; cell adhesion molecule binding; gamma-catenin binding; GTPase activating protein binding; identical protein binding; metal ion binding; protein binding; protein tyrosine kinase binding","actin cytoskeleton; adherens junction; anchoring junction; apical junction complex; catenin complex; cell junction; cortical actin cytoskeleton; cytoplasm; cytoplasmic side of plasma membrane; endosome; extracellular exosome; extracellular region; flotillin complex; glutamatergic synapse; Golgi apparatus; lamellipodium; lateral plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; postsynapse; trans-Golgi network","Extracellular matrix","cadherin 1","http://www.ncbi.nlm.nih.gov/gene/?term=999","999","12550","83502",null,null,null,"P12830","A0A0R4IZW5","Q9R0T4","A0A8I3N5Q4",null,"F7H4U0","GO:0015629; GO:0005912; GO:0070161; GO:0043296; GO:0016342; GO:0030054; GO:0030864; GO:0005737; GO:0009898; GO:0005768; GO:0070062; GO:0005576; GO:0016600; GO:0098978; GO:0005794; GO:0030027; GO:0016328; GO:0016020; GO:0048471; GO:0005886; GO:0098794; GO:0005802","GO:0030506; GO:0008013; GO:0045296; GO:0005509; GO:0050839; GO:0045295; GO:0032794; GO:0042802; GO:0046872; GO:0005515; GO:1990782","GO:0034332; GO:0007155; GO:0098609; GO:0098742; GO:0071681; GO:0071285; GO:0007156; GO:0030517; GO:0030336; GO:0022408; GO:0031175; GO:0021983; GO:0045893; GO:0042307; GO:0072659; GO:0010468; GO:0099576; GO:0140459; GO:0010033; GO:0009636; GO:0009410; GO:0007416","PTHR24027:SF435","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1748|UniProtKB=P12830","P06959; P00004; P00012; P00057"]
["E-Cadherin - phospho","Ser838/Ser840","CDH1","135","rb",null,1,2,2,2,2,2,"# 0203",".ALZ., .BLC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CP., .CSP., .DEV., .DI., .DRR., .EMC., .HIPPO., .MEL., .MIG., .OP., .OPA., .OT., .TRASR., .TYR., .WNT.","CCKR signaling map; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Wnt signaling pathway","CADHERIN-1","adherens junction organization; cell adhesion; cell-cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; cellular response to indole-3-methanol; cellular response to lithium ion; homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of axon extension; negative regulation of cell migration; negative regulation of cell-cell adhesion; neuron projection development; pituitary gland development; positive regulation of DNA-templated transcription; positive regulation of protein import into nucleus; protein localization to plasma membrane; regulation of gene expression; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; response to Gram-positive bacterium; response to organic substance; response to toxic substance; response to xenobiotic stimulus; synapse assembly","ankyrin binding; beta-catenin binding; cadherin binding; calcium ion binding; cell adhesion molecule binding; gamma-catenin binding; GTPase activating protein binding; identical protein binding; metal ion binding; protein binding; protein tyrosine kinase binding","actin cytoskeleton; adherens junction; anchoring junction; apical junction complex; catenin complex; cell junction; cortical actin cytoskeleton; cytoplasm; cytoplasmic side of plasma membrane; endosome; extracellular exosome; extracellular region; flotillin complex; glutamatergic synapse; Golgi apparatus; lamellipodium; lateral plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; postsynapse; trans-Golgi network","Extracellular matrix","cadherin 1","http://www.ncbi.nlm.nih.gov/gene/?term=999","999","12550","83502",null,null,null,"P12830","A0A0R4IZW5","Q9R0T4","A0A8I3N5Q4",null,"F7H4U0","GO:0015629; GO:0005912; GO:0070161; GO:0043296; GO:0016342; GO:0030054; GO:0030864; GO:0005737; GO:0009898; GO:0005768; GO:0070062; GO:0005576; GO:0016600; GO:0098978; GO:0005794; GO:0030027; GO:0016328; GO:0016020; GO:0048471; GO:0005886; GO:0098794; GO:0005802","GO:0030506; GO:0008013; GO:0045296; GO:0005509; GO:0050839; GO:0045295; GO:0032794; GO:0042802; GO:0046872; GO:0005515; GO:1990782","GO:0034332; GO:0007155; GO:0098609; GO:0098742; GO:0071681; GO:0071285; GO:0007156; GO:0030517; GO:0030336; GO:0022408; GO:0031175; GO:0021983; GO:0045893; GO:0042307; GO:0072659; GO:0010468; GO:0099576; GO:0140459; GO:0010033; GO:0009636; GO:0009410; GO:0007416","PTHR24027:SF435","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1748|UniProtKB=P12830","P06959; P00004; P00012; P00057"]
["eEF2",null,"EEF2","95","rb",null,2,2,2,2,2,2,"# 2159",".AMPK., .CSP., .OP., .OT., .SREME., .TRASR.",null,"ELONGATION FACTOR 2","hematopoietic progenitor cell differentiation; positive regulation of translation; translation; translational elongation","cadherin binding; GTP binding; GTPase activity; nucleotide binding; protein binding; protein kinase binding; ribosome binding; RNA binding; translation elongation factor activity","aggresome; cellular anatomical entity; cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; membrane; nucleus; plasma membrane; polysome; ribonucleoprotein complex; secretory granule lumen; synapse","Translational control","eukaryotic translation elongation factor 2","http://www.ncbi.nlm.nih.gov/gene/?term=1938","1938","13629","29565","476744",null,"721806","P13639","P58252","P05197","A0A8I3RV50","I3LII3","A0A1D5QQX5","GO:0016235; GO:0110165; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1904813; GO:0016020; GO:0005634; GO:0005886; GO:0005844; GO:1990904; GO:0034774; GO:0045202","GO:0045296; GO:0005525; GO:0003924; GO:0000166; GO:0005515; GO:0019901; GO:0043022; GO:0003723; GO:0003746","GO:0002244; GO:0045727; GO:0006412; GO:0006414","PTHR42908:SF35","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3214|UniProtKB=P13639"]
["eEF2 - phospho","Thr56","EEF2","95","rb",null,1,1,1,1.1000000000000001,1,1,"# 1774",".AMPK., .CSP., .OP., .OT., .SREME., .TRASR.",null,"ELONGATION FACTOR 2","hematopoietic progenitor cell differentiation; positive regulation of translation; translation; translational elongation","cadherin binding; GTP binding; GTPase activity; nucleotide binding; protein binding; protein kinase binding; ribosome binding; RNA binding; translation elongation factor activity","aggresome; cellular anatomical entity; cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; membrane; nucleus; plasma membrane; polysome; ribonucleoprotein complex; secretory granule lumen; synapse","Translational control","eukaryotic translation elongation factor 2","http://www.ncbi.nlm.nih.gov/gene/?term=1938","1938","13629","29565","476744",null,"721806","P13639","P58252","P05197","A0A8I3RV50","I3LII3","A0A1D5QQX5","GO:0016235; GO:0110165; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1904813; GO:0016020; GO:0005634; GO:0005886; GO:0005844; GO:1990904; GO:0034774; GO:0045202","GO:0045296; GO:0005525; GO:0003924; GO:0000166; GO:0005515; GO:0019901; GO:0043022; GO:0003723; GO:0003746","GO:0002244; GO:0045727; GO:0006412; GO:0006414","PTHR42908:SF35","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3214|UniProtKB=P13639"]
["eEF2k",null,"EEF2K","95","rb",null,2,1,1,8,8,1,"# 0231",".AMPK., .APO., .cAMP., .CD., .CSP., .GPCR., .INS., .OPA., .OXS., .P38., .SREME., .ST.","p38 MAPK pathway; Oxidative stress response","EUKARYOTIC ELONGATION FACTOR 2 KINASE","cellular response to anoxia; cellular response to brain-derived neurotrophic factor stimulus; cellular response to calcium ion; cellular response to cAMP; cellular response to insulin stimulus; negative regulation of apoptotic process; phosphorylation; positive regulation of dendritic spine morphogenesis; positive regulation of endocytosis; positive regulation of synapse assembly; protein autophosphorylation; protein phosphorylation; regulation of protein autophosphorylation; regulation of translation at postsynapse; response to ischemia; response to prolactin; translational elongation","ATP binding; calcium ion binding; calmodulin binding; elongation factor-2 kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity; translation factor activity, RNA binding; translation regulator activity","cytoplasm; cytosol; dendritic spine; glutamatergic synapse; postsynaptic density","Translational control","eukaryotic elongation factor 2 kinase","http://www.ncbi.nlm.nih.gov/gene/?term=29904","29904","13631","25435",null,null,null,"O00418","O08796","P70531","A0A8I3MLJ7","A0A286ZV41","A0A5F8A6J3","GO:0005737; GO:0005829; GO:0043197; GO:0098978; GO:0014069","GO:0005524; GO:0005509; GO:0005516; GO:0004686; GO:0016301; GO:0000166; GO:0004672; GO:0004674; GO:0016740; GO:0008135; GO:0045182","GO:0071454; GO:1990416; GO:0071277; GO:0071320; GO:0032869; GO:0043066; GO:0016310; GO:0061003; GO:0045807; GO:0051965; GO:0046777; GO:0006468; GO:0031952; GO:0140245; GO:0002931; GO:1990637; GO:0006414","PTHR45992:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24615|UniProtKB=O00418","P05918; P00046"]
["eEF2k - phospho","Ser366","EEF2K","105","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2192",".AMPK., .APO., .cAMP., .CD., .CSP., .GPCR., .INS., .OPA., .OXS., .P38., .SREME., .ST.","p38 MAPK pathway; Oxidative stress response","EUKARYOTIC ELONGATION FACTOR 2 KINASE","cellular response to anoxia; cellular response to brain-derived neurotrophic factor stimulus; cellular response to calcium ion; cellular response to cAMP; cellular response to insulin stimulus; negative regulation of apoptotic process; phosphorylation; positive regulation of dendritic spine morphogenesis; positive regulation of endocytosis; positive regulation of synapse assembly; protein autophosphorylation; protein phosphorylation; regulation of protein autophosphorylation; regulation of translation at postsynapse; response to ischemia; response to prolactin; translational elongation","ATP binding; calcium ion binding; calmodulin binding; elongation factor-2 kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity; translation factor activity, RNA binding; translation regulator activity","cytoplasm; cytosol; dendritic spine; glutamatergic synapse; postsynaptic density",null,"eukaryotic elongation factor 2 kinase","http://www.ncbi.nlm.nih.gov/gene/?term=29904","29904","13631","25435",null,null,null,"O00418","O08796","P70531","A0A8I3MLJ7","A0A286ZV41","A0A5F8A6J3","GO:0005737; GO:0005829; GO:0043197; GO:0098978; GO:0014069","GO:0005524; GO:0005509; GO:0005516; GO:0004686; GO:0016301; GO:0000166; GO:0004672; GO:0004674; GO:0016740; GO:0008135; GO:0045182","GO:0071454; GO:1990416; GO:0071277; GO:0071320; GO:0032869; GO:0043066; GO:0016310; GO:0061003; GO:0045807; GO:0051965; GO:0046777; GO:0006468; GO:0031952; GO:0140245; GO:0002931; GO:1990637; GO:0006414","PTHR45992:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24615|UniProtKB=O00418","P05918; P00046"]
["Eg5",null,"KIF11","120","ms",null,1,4,4,4,4,4,"# 1279",".CCP., .CCY., .CP., .OP.",null,"KINESIN-LIKE PROTEIN KIF11","cell cycle; cell division; microtubule-based movement; mitotic cell cycle; mitotic centrosome separation; mitotic sister chromatid segregation; mitotic spindle assembly; mitotic spindle organization; regulation of mitotic centrosome separation; spindle assembly; spindle elongation; spindle organization","ATP binding; microtubule binding; microtubule motor activity; nucleotide binding; plus-end-directed microtubule motor activity; protein binding; protein kinase binding","cytoplasm; cytoskeleton; cytosol; kinesin complex; membrane; microtubule; mitotic spindle; nucleus; protein-containing complex; spindle; spindle microtubule; spindle pole","Cell cycle control","kinesin family member 11","http://www.ncbi.nlm.nih.gov/gene/?term=3832","3832","16551",null,null,null,"699174","P52732","Q6P9P6","A0A8I5ZY18","A0A8I3P3K7","A0A5G2QBS6","F7FKH9","GO:0005737; GO:0005856; GO:0005829; GO:0005871; GO:0016020; GO:0005874; GO:0072686; GO:0005634; GO:0032991; GO:0005819; GO:0005876; GO:0000922","GO:0005524; GO:0008017; GO:0003777; GO:0000166; GO:0008574; GO:0005515; GO:0019901","GO:0007049; GO:0051301; GO:0007018; GO:0000278; GO:0007100; GO:0000070; GO:0090307; GO:0007052; GO:0046602; GO:0051225; GO:0051231; GO:0007051","PTHR47970:SF26","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6388|UniProtKB=P52732"]
["Eg5 - phospho","Thr927","KIF11","120","rb",null,6,2,6,6,6,6,"# 1281",".CCP., .CCY., .CP., .OP.",null,"KINESIN-LIKE PROTEIN KIF11","cell cycle; cell division; microtubule-based movement; mitotic cell cycle; mitotic centrosome separation; mitotic sister chromatid segregation; mitotic spindle assembly; mitotic spindle organization; regulation of mitotic centrosome separation; spindle assembly; spindle elongation; spindle organization","ATP binding; microtubule binding; microtubule motor activity; nucleotide binding; plus-end-directed microtubule motor activity; protein binding; protein kinase binding","cytoplasm; cytoskeleton; cytosol; kinesin complex; membrane; microtubule; mitotic spindle; nucleus; protein-containing complex; spindle; spindle microtubule; spindle pole","Cell cycle control","kinesin family member 11","http://www.ncbi.nlm.nih.gov/gene/?term=3832","3832","16551",null,null,null,"699174","P52732","Q6P9P6","A0A8I5ZY18","A0A8I3P3K7","A0A5G2QBS6","F7FKH9","GO:0005737; GO:0005856; GO:0005829; GO:0005871; GO:0016020; GO:0005874; GO:0072686; GO:0005634; GO:0032991; GO:0005819; GO:0005876; GO:0000922","GO:0005524; GO:0008017; GO:0003777; GO:0000166; GO:0008574; GO:0005515; GO:0019901","GO:0007049; GO:0051301; GO:0007018; GO:0000278; GO:0007100; GO:0000070; GO:0090307; GO:0007052; GO:0046602; GO:0051225; GO:0051231; GO:0007051","PTHR47970:SF26","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6388|UniProtKB=P52732"]
["EGF Receptor",null,"EGFR","175","rb",null,4,4,4,4,4,4,"# 1837",".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; EGF receptor signaling pathway","EPIDERMAL GROWTH FACTOR RECEPTOR","activation of phospholipase C activity; cell morphogenesis; cell population proliferation; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to amino acid stimulus; cellular response to cadmium ion; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to growth factor stimulus; cellular response to reactive oxygen species; cerebral cortex cell migration; digestive tract morphogenesis; embryonic placenta development; epidermal growth factor receptor signaling pathway; epidermis development; epithelial cell proliferation; ERBB signaling pathway; ERBB2-EGFR signaling pathway; eyelid development in camera-type eye; hair follicle development; learning or memory; MAPK cascade; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of cardiocyte differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein catabolic process; neurogenesis; ossification; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of miRNA transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide mediated signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein kinase C activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein insertion into membrane; protein phosphorylation; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; response to UV-A; salivary gland morphogenesis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; viral entry into host cell","actin filament binding; ATP binding; ATPase binding; cadherin binding; chromatin binding; double-stranded DNA binding; enzyme binding; epidermal growth factor binding; epidermal growth factor receptor activity; identical protein binding; kinase activity; kinase binding; MAP kinase kinase kinase activity; molecular function activator activity; nitric-oxide synthase regulator activity; nucleotide binding; phospholipase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activator activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding; virus receptor activity","basal plasma membrane; basolateral plasma membrane; cell junction; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasm; early endosome membrane; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; intracellular vesicle; membrane; membrane raft; multivesicular body, internal vesicle lumen; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; protein-containing complex; receptor complex; ruffle membrane; Shc-EGFR complex","Tyrosine kinase / adaptor","epidermal growth factor receptor","http://www.ncbi.nlm.nih.gov/gene/?term=1956","1956","13649",null,null,null,null,"P00533","Q01279","A0A8I5ZMJ2","A0A8I3NJD5","A0A286ZV23","A0A1D5QDK1","GO:0009925; GO:0016323; GO:0030054; GO:0009986; GO:0030669; GO:0005737; GO:0031901; GO:0030139; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0000139; GO:0097708; GO:0016020; GO:0045121; GO:0097489; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0032991; GO:0043235; GO:0032587; GO:0070435","GO:0051015; GO:0005524; GO:0051117; GO:0045296; GO:0003682; GO:0003690; GO:0019899; GO:0048408; GO:0005006; GO:0042802; GO:0016301; GO:0019900; GO:0004709; GO:0140677; GO:0030235; GO:0000166; GO:0016004; GO:0005515; GO:0004672; GO:0019903; GO:0030296; GO:0004713; GO:0016740; GO:0030297; GO:0004714; GO:0004888; GO:0031625; GO:0001618","GO:0007202; GO:0000902; GO:0008283; GO:0007166; GO:0098609; GO:0071230; GO:0071276; GO:0071364; GO:0071392; GO:0071363; GO:0034614; GO:0021795; GO:0048546; GO:0001892; GO:0007173; GO:0008544; GO:0050673; GO:0038127; GO:0038134; GO:0061029; GO:0001942; GO:0007611; GO:0000165; GO:0060571; GO:0043066; GO:1905208; GO:0042059; GO:0042177; GO:0022008; GO:0001503; GO:0038083; GO:0018108; GO:0016310; GO:0090263; GO:0030307; GO:0030335; GO:0008284; GO:0045737; GO:0045739; GO:0045740; GO:0045893; GO:0050679; GO:0070374; GO:0048146; GO:1900087; GO:0033674; GO:0043406; GO:1902895; GO:1901224; GO:0010750; GO:0033138; GO:0042327; GO:0051897; GO:1900020; GO:1903078; GO:0001934; GO:0045944; GO:0046777; GO:0051205; GO:0006468; GO:0042127; GO:0070372; GO:0046328; GO:0050999; GO:0050730; GO:0014066; GO:0070141; GO:0007435; GO:0007165; GO:0007169; GO:0046718","PTHR24416:SF91","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3236|UniProtKB=P00533","P06664; P00012; P00018"]
["EGF Receptor",null,"EGFR","175","rb",null,1,4,"n/a","n/a","n/a","n/a","# 3073",".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DDR., .DEV., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; EGF receptor signaling pathway","EPIDERMAL GROWTH FACTOR RECEPTOR","activation of phospholipase C activity; cell morphogenesis; cell population proliferation; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to amino acid stimulus; cellular response to cadmium ion; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to growth factor stimulus; cellular response to reactive oxygen species; cerebral cortex cell migration; digestive tract morphogenesis; embryonic placenta development; epidermal growth factor receptor signaling pathway; epidermis development; epithelial cell proliferation; ERBB signaling pathway; ERBB2-EGFR signaling pathway; eyelid development in camera-type eye; hair follicle development; learning or memory; MAPK cascade; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of cardiocyte differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein catabolic process; neurogenesis; ossification; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of miRNA transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide mediated signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein kinase C activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein insertion into membrane; protein phosphorylation; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; response to UV-A; salivary gland morphogenesis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; viral entry into host cell","actin filament binding; ATP binding; ATPase binding; cadherin binding; chromatin binding; double-stranded DNA binding; enzyme binding; epidermal growth factor binding; epidermal growth factor receptor activity; identical protein binding; kinase activity; kinase binding; MAP kinase kinase kinase activity; molecular function activator activity; nitric-oxide synthase regulator activity; nucleotide binding; phospholipase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activator activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding; virus receptor activity","basal plasma membrane; basolateral plasma membrane; cell junction; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasm; early endosome membrane; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; intracellular vesicle; membrane; membrane raft; multivesicular body, internal vesicle lumen; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; protein-containing complex; receptor complex; ruffle membrane; Shc-EGFR complex","Tyrosine kinase / adaptor","epidermal growth factor receptor","http://www.ncbi.nlm.nih.gov/gene/?term=1956","1956","13649",null,null,null,null,"P00533","Q01279","A0A8I5ZMJ2","A0A8I3NJD5","A0A286ZV23","A0A1D5QDK1","GO:0009925; GO:0016323; GO:0030054; GO:0009986; GO:0030669; GO:0005737; GO:0031901; GO:0030139; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0000139; GO:0097708; GO:0016020; GO:0045121; GO:0097489; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0032991; GO:0043235; GO:0032587; GO:0070435","GO:0051015; GO:0005524; GO:0051117; GO:0045296; GO:0003682; GO:0003690; GO:0019899; GO:0048408; GO:0005006; GO:0042802; GO:0016301; GO:0019900; GO:0004709; GO:0140677; GO:0030235; GO:0000166; GO:0016004; GO:0005515; GO:0004672; GO:0019903; GO:0030296; GO:0004713; GO:0016740; GO:0030297; GO:0004714; GO:0004888; GO:0031625; GO:0001618","GO:0007202; GO:0000902; GO:0008283; GO:0007166; GO:0098609; GO:0071230; GO:0071276; GO:0071364; GO:0071392; GO:0071363; GO:0034614; GO:0021795; GO:0048546; GO:0001892; GO:0007173; GO:0008544; GO:0050673; GO:0038127; GO:0038134; GO:0061029; GO:0001942; GO:0007611; GO:0000165; GO:0060571; GO:0043066; GO:1905208; GO:0042059; GO:0042177; GO:0022008; GO:0001503; GO:0038083; GO:0018108; GO:0016310; GO:0090263; GO:0030307; GO:0030335; GO:0008284; GO:0045737; GO:0045739; GO:0045740; GO:0045893; GO:0050679; GO:0070374; GO:0048146; GO:1900087; GO:0033674; GO:0043406; GO:1902895; GO:1901224; GO:0010750; GO:0033138; GO:0042327; GO:0051897; GO:1900020; GO:1903078; GO:0001934; GO:0045944; GO:0046777; GO:0051205; GO:0006468; GO:0042127; GO:0070372; GO:0046328; GO:0050999; GO:0050730; GO:0014066; GO:0070141; GO:0007435; GO:0007165; GO:0007169; GO:0046718","PTHR24416:SF91","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3236|UniProtKB=P00533","P06664; P00012; P00018"]
["EGF Receptor - phospho","Tyr1045","EGFR","175","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1778",".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; EGF receptor signaling pathway","EPIDERMAL GROWTH FACTOR RECEPTOR","activation of phospholipase C activity; cell morphogenesis; cell population proliferation; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to amino acid stimulus; cellular response to cadmium ion; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to growth factor stimulus; cellular response to reactive oxygen species; cerebral cortex cell migration; digestive tract morphogenesis; embryonic placenta development; epidermal growth factor receptor signaling pathway; epidermis development; epithelial cell proliferation; ERBB signaling pathway; ERBB2-EGFR signaling pathway; eyelid development in camera-type eye; hair follicle development; learning or memory; MAPK cascade; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of cardiocyte differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein catabolic process; neurogenesis; ossification; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of miRNA transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide mediated signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein kinase C activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein insertion into membrane; protein phosphorylation; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; response to UV-A; salivary gland morphogenesis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; viral entry into host cell","actin filament binding; ATP binding; ATPase binding; cadherin binding; chromatin binding; double-stranded DNA binding; enzyme binding; epidermal growth factor binding; epidermal growth factor receptor activity; identical protein binding; kinase activity; kinase binding; MAP kinase kinase kinase activity; molecular function activator activity; nitric-oxide synthase regulator activity; nucleotide binding; phospholipase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activator activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding; virus receptor activity","basal plasma membrane; basolateral plasma membrane; cell junction; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasm; early endosome membrane; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; intracellular vesicle; membrane; membrane raft; multivesicular body, internal vesicle lumen; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; protein-containing complex; receptor complex; ruffle membrane; Shc-EGFR complex","Tyrosine kinase / adaptor","epidermal growth factor receptor","http://www.ncbi.nlm.nih.gov/gene/?term=1956","1956","13649",null,null,null,null,"P00533","Q01279","A0A8I5ZMJ2","A0A8I3NJD5","A0A286ZV23","A0A1D5QDK1","GO:0009925; GO:0016323; GO:0030054; GO:0009986; GO:0030669; GO:0005737; GO:0031901; GO:0030139; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0000139; GO:0097708; GO:0016020; GO:0045121; GO:0097489; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0032991; GO:0043235; GO:0032587; GO:0070435","GO:0051015; GO:0005524; GO:0051117; GO:0045296; GO:0003682; GO:0003690; GO:0019899; GO:0048408; GO:0005006; GO:0042802; GO:0016301; GO:0019900; GO:0004709; GO:0140677; GO:0030235; GO:0000166; GO:0016004; GO:0005515; GO:0004672; GO:0019903; GO:0030296; GO:0004713; GO:0016740; GO:0030297; GO:0004714; GO:0004888; GO:0031625; GO:0001618","GO:0007202; GO:0000902; GO:0008283; GO:0007166; GO:0098609; GO:0071230; GO:0071276; GO:0071364; GO:0071392; GO:0071363; GO:0034614; GO:0021795; GO:0048546; GO:0001892; GO:0007173; GO:0008544; GO:0050673; GO:0038127; GO:0038134; GO:0061029; GO:0001942; GO:0007611; GO:0000165; GO:0060571; GO:0043066; GO:1905208; GO:0042059; GO:0042177; GO:0022008; GO:0001503; GO:0038083; GO:0018108; GO:0016310; GO:0090263; GO:0030307; GO:0030335; GO:0008284; GO:0045737; GO:0045739; GO:0045740; GO:0045893; GO:0050679; GO:0070374; GO:0048146; GO:1900087; GO:0033674; GO:0043406; GO:1902895; GO:1901224; GO:0010750; GO:0033138; GO:0042327; GO:0051897; GO:1900020; GO:1903078; GO:0001934; GO:0045944; GO:0046777; GO:0051205; GO:0006468; GO:0042127; GO:0070372; GO:0046328; GO:0050999; GO:0050730; GO:0014066; GO:0070141; GO:0007435; GO:0007165; GO:0007169; GO:0046718","PTHR24416:SF91","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3236|UniProtKB=P00533","P06664; P00012; P00018"]
["EGF Receptor - phospho","Tyr1068","EGFR","175","rb",null,4,4,4,4,4,4,"# 0876",".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; EGF receptor signaling pathway","EPIDERMAL GROWTH FACTOR RECEPTOR","activation of phospholipase C activity; cell morphogenesis; cell population proliferation; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to amino acid stimulus; cellular response to cadmium ion; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to growth factor stimulus; cellular response to reactive oxygen species; cerebral cortex cell migration; digestive tract morphogenesis; embryonic placenta development; epidermal growth factor receptor signaling pathway; epidermis development; epithelial cell proliferation; ERBB signaling pathway; ERBB2-EGFR signaling pathway; eyelid development in camera-type eye; hair follicle development; learning or memory; MAPK cascade; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of cardiocyte differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein catabolic process; neurogenesis; ossification; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of miRNA transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide mediated signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein kinase C activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein insertion into membrane; protein phosphorylation; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; response to UV-A; salivary gland morphogenesis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; viral entry into host cell","actin filament binding; ATP binding; ATPase binding; cadherin binding; chromatin binding; double-stranded DNA binding; enzyme binding; epidermal growth factor binding; epidermal growth factor receptor activity; identical protein binding; kinase activity; kinase binding; MAP kinase kinase kinase activity; molecular function activator activity; nitric-oxide synthase regulator activity; nucleotide binding; phospholipase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activator activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding; virus receptor activity","basal plasma membrane; basolateral plasma membrane; cell junction; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasm; early endosome membrane; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; intracellular vesicle; membrane; membrane raft; multivesicular body, internal vesicle lumen; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; protein-containing complex; receptor complex; ruffle membrane; Shc-EGFR complex","Tyrosine kinase / adaptor","epidermal growth factor receptor","http://www.ncbi.nlm.nih.gov/gene/?term=1956","1956","13649",null,null,null,null,"P00533","Q01279","A0A8I5ZMJ2","A0A8I3NJD5","A0A286ZV23","A0A1D5QDK1","GO:0009925; GO:0016323; GO:0030054; GO:0009986; GO:0030669; GO:0005737; GO:0031901; GO:0030139; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0000139; GO:0097708; GO:0016020; GO:0045121; GO:0097489; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0032991; GO:0043235; GO:0032587; GO:0070435","GO:0051015; GO:0005524; GO:0051117; GO:0045296; GO:0003682; GO:0003690; GO:0019899; GO:0048408; GO:0005006; GO:0042802; GO:0016301; GO:0019900; GO:0004709; GO:0140677; GO:0030235; GO:0000166; GO:0016004; GO:0005515; GO:0004672; GO:0019903; GO:0030296; GO:0004713; GO:0016740; GO:0030297; GO:0004714; GO:0004888; GO:0031625; GO:0001618","GO:0007202; GO:0000902; GO:0008283; GO:0007166; GO:0098609; GO:0071230; GO:0071276; GO:0071364; GO:0071392; GO:0071363; GO:0034614; GO:0021795; GO:0048546; GO:0001892; GO:0007173; GO:0008544; GO:0050673; GO:0038127; GO:0038134; GO:0061029; GO:0001942; GO:0007611; GO:0000165; GO:0060571; GO:0043066; GO:1905208; GO:0042059; GO:0042177; GO:0022008; GO:0001503; GO:0038083; GO:0018108; GO:0016310; GO:0090263; GO:0030307; GO:0030335; GO:0008284; GO:0045737; GO:0045739; GO:0045740; GO:0045893; GO:0050679; GO:0070374; GO:0048146; GO:1900087; GO:0033674; GO:0043406; GO:1902895; GO:1901224; GO:0010750; GO:0033138; GO:0042327; GO:0051897; GO:1900020; GO:1903078; GO:0001934; GO:0045944; GO:0046777; GO:0051205; GO:0006468; GO:0042127; GO:0070372; GO:0046328; GO:0050999; GO:0050730; GO:0014066; GO:0070141; GO:0007435; GO:0007165; GO:0007169; GO:0046718","PTHR24416:SF91","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3236|UniProtKB=P00533","P06664; P00012; P00018"]
["EGF Receptor - phospho","Tyr1068","EGFR","175","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2271",".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DDR., .DEV., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; EGF receptor signaling pathway","EPIDERMAL GROWTH FACTOR RECEPTOR","activation of phospholipase C activity; cell morphogenesis; cell population proliferation; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to amino acid stimulus; cellular response to cadmium ion; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to growth factor stimulus; cellular response to reactive oxygen species; cerebral cortex cell migration; digestive tract morphogenesis; embryonic placenta development; epidermal growth factor receptor signaling pathway; epidermis development; epithelial cell proliferation; ERBB signaling pathway; ERBB2-EGFR signaling pathway; eyelid development in camera-type eye; hair follicle development; learning or memory; MAPK cascade; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of cardiocyte differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein catabolic process; neurogenesis; ossification; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of miRNA transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide mediated signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein kinase C activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein insertion into membrane; protein phosphorylation; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; response to UV-A; salivary gland morphogenesis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; viral entry into host cell","actin filament binding; ATP binding; ATPase binding; cadherin binding; chromatin binding; double-stranded DNA binding; enzyme binding; epidermal growth factor binding; epidermal growth factor receptor activity; identical protein binding; kinase activity; kinase binding; MAP kinase kinase kinase activity; molecular function activator activity; nitric-oxide synthase regulator activity; nucleotide binding; phospholipase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activator activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding; virus receptor activity","basal plasma membrane; basolateral plasma membrane; cell junction; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasm; early endosome membrane; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; intracellular vesicle; membrane; membrane raft; multivesicular body, internal vesicle lumen; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; protein-containing complex; receptor complex; ruffle membrane; Shc-EGFR complex","Tyrosine kinase / adaptor","epidermal growth factor receptor","http://www.ncbi.nlm.nih.gov/gene/?term=1956","1956","13649",null,null,null,null,"P00533","Q01279","A0A8I5ZMJ2","A0A8I3NJD5","A0A286ZV23","A0A1D5QDK1","GO:0009925; GO:0016323; GO:0030054; GO:0009986; GO:0030669; GO:0005737; GO:0031901; GO:0030139; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0000139; GO:0097708; GO:0016020; GO:0045121; GO:0097489; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0032991; GO:0043235; GO:0032587; GO:0070435","GO:0051015; GO:0005524; GO:0051117; GO:0045296; GO:0003682; GO:0003690; GO:0019899; GO:0048408; GO:0005006; GO:0042802; GO:0016301; GO:0019900; GO:0004709; GO:0140677; GO:0030235; GO:0000166; GO:0016004; GO:0005515; GO:0004672; GO:0019903; GO:0030296; GO:0004713; GO:0016740; GO:0030297; GO:0004714; GO:0004888; GO:0031625; GO:0001618","GO:0007202; GO:0000902; GO:0008283; GO:0007166; GO:0098609; GO:0071230; GO:0071276; GO:0071364; GO:0071392; GO:0071363; GO:0034614; GO:0021795; GO:0048546; GO:0001892; GO:0007173; GO:0008544; GO:0050673; GO:0038127; GO:0038134; GO:0061029; GO:0001942; GO:0007611; GO:0000165; GO:0060571; GO:0043066; GO:1905208; GO:0042059; GO:0042177; GO:0022008; GO:0001503; GO:0038083; GO:0018108; GO:0016310; GO:0090263; GO:0030307; GO:0030335; GO:0008284; GO:0045737; GO:0045739; GO:0045740; GO:0045893; GO:0050679; GO:0070374; GO:0048146; GO:1900087; GO:0033674; GO:0043406; GO:1902895; GO:1901224; GO:0010750; GO:0033138; GO:0042327; GO:0051897; GO:1900020; GO:1903078; GO:0001934; GO:0045944; GO:0046777; GO:0051205; GO:0006468; GO:0042127; GO:0070372; GO:0046328; GO:0050999; GO:0050730; GO:0014066; GO:0070141; GO:0007435; GO:0007165; GO:0007169; GO:0046718","PTHR24416:SF91","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3236|UniProtKB=P00533","P06664; P00012; P00018"]
["EGF Receptor - phospho","Tyr1173","EGFR","175","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1224",".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DDR., .DEV., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; EGF receptor signaling pathway","EPIDERMAL GROWTH FACTOR RECEPTOR","activation of phospholipase C activity; cell morphogenesis; cell population proliferation; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to amino acid stimulus; cellular response to cadmium ion; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to growth factor stimulus; cellular response to reactive oxygen species; cerebral cortex cell migration; digestive tract morphogenesis; embryonic placenta development; epidermal growth factor receptor signaling pathway; epidermis development; epithelial cell proliferation; ERBB signaling pathway; ERBB2-EGFR signaling pathway; eyelid development in camera-type eye; hair follicle development; learning or memory; MAPK cascade; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of cardiocyte differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein catabolic process; neurogenesis; ossification; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of miRNA transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide mediated signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein kinase C activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein insertion into membrane; protein phosphorylation; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; response to UV-A; salivary gland morphogenesis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; viral entry into host cell","actin filament binding; ATP binding; ATPase binding; cadherin binding; chromatin binding; double-stranded DNA binding; enzyme binding; epidermal growth factor binding; epidermal growth factor receptor activity; identical protein binding; kinase activity; kinase binding; MAP kinase kinase kinase activity; molecular function activator activity; nitric-oxide synthase regulator activity; nucleotide binding; phospholipase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activator activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding; virus receptor activity","basal plasma membrane; basolateral plasma membrane; cell junction; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasm; early endosome membrane; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; intracellular vesicle; membrane; membrane raft; multivesicular body, internal vesicle lumen; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; protein-containing complex; receptor complex; ruffle membrane; Shc-EGFR complex","Tyrosine kinase / adaptor","epidermal growth factor receptor","http://www.ncbi.nlm.nih.gov/gene/?term=1956","1956","13649",null,null,null,null,"P00533","Q01279","A0A8I5ZMJ2","A0A8I3NJD5","A0A286ZV23","A0A1D5QDK1","GO:0009925; GO:0016323; GO:0030054; GO:0009986; GO:0030669; GO:0005737; GO:0031901; GO:0030139; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0000139; GO:0097708; GO:0016020; GO:0045121; GO:0097489; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0032991; GO:0043235; GO:0032587; GO:0070435","GO:0051015; GO:0005524; GO:0051117; GO:0045296; GO:0003682; GO:0003690; GO:0019899; GO:0048408; GO:0005006; GO:0042802; GO:0016301; GO:0019900; GO:0004709; GO:0140677; GO:0030235; GO:0000166; GO:0016004; GO:0005515; GO:0004672; GO:0019903; GO:0030296; GO:0004713; GO:0016740; GO:0030297; GO:0004714; GO:0004888; GO:0031625; GO:0001618","GO:0007202; GO:0000902; GO:0008283; GO:0007166; GO:0098609; GO:0071230; GO:0071276; GO:0071364; GO:0071392; GO:0071363; GO:0034614; GO:0021795; GO:0048546; GO:0001892; GO:0007173; GO:0008544; GO:0050673; GO:0038127; GO:0038134; GO:0061029; GO:0001942; GO:0007611; GO:0000165; GO:0060571; GO:0043066; GO:1905208; GO:0042059; GO:0042177; GO:0022008; GO:0001503; GO:0038083; GO:0018108; GO:0016310; GO:0090263; GO:0030307; GO:0030335; GO:0008284; GO:0045737; GO:0045739; GO:0045740; GO:0045893; GO:0050679; GO:0070374; GO:0048146; GO:1900087; GO:0033674; GO:0043406; GO:1902895; GO:1901224; GO:0010750; GO:0033138; GO:0042327; GO:0051897; GO:1900020; GO:1903078; GO:0001934; GO:0045944; GO:0046777; GO:0051205; GO:0006468; GO:0042127; GO:0070372; GO:0046328; GO:0050999; GO:0050730; GO:0014066; GO:0070141; GO:0007435; GO:0007165; GO:0007169; GO:0046718","PTHR24416:SF91","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3236|UniProtKB=P00533","P06664; P00012; P00018"]
["EGF Receptor - phospho","Tyr845","EGFR","175","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0871",".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; EGF receptor signaling pathway","EPIDERMAL GROWTH FACTOR RECEPTOR","activation of phospholipase C activity; cell morphogenesis; cell population proliferation; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to amino acid stimulus; cellular response to cadmium ion; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to growth factor stimulus; cellular response to reactive oxygen species; cerebral cortex cell migration; digestive tract morphogenesis; embryonic placenta development; epidermal growth factor receptor signaling pathway; epidermis development; epithelial cell proliferation; ERBB signaling pathway; ERBB2-EGFR signaling pathway; eyelid development in camera-type eye; hair follicle development; learning or memory; MAPK cascade; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of cardiocyte differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein catabolic process; neurogenesis; ossification; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of miRNA transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide mediated signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein kinase C activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein insertion into membrane; protein phosphorylation; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; response to UV-A; salivary gland morphogenesis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; viral entry into host cell","actin filament binding; ATP binding; ATPase binding; cadherin binding; chromatin binding; double-stranded DNA binding; enzyme binding; epidermal growth factor binding; epidermal growth factor receptor activity; identical protein binding; kinase activity; kinase binding; MAP kinase kinase kinase activity; molecular function activator activity; nitric-oxide synthase regulator activity; nucleotide binding; phospholipase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activator activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding; virus receptor activity","basal plasma membrane; basolateral plasma membrane; cell junction; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasm; early endosome membrane; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; intracellular vesicle; membrane; membrane raft; multivesicular body, internal vesicle lumen; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; protein-containing complex; receptor complex; ruffle membrane; Shc-EGFR complex","Tyrosine kinase / adaptor","epidermal growth factor receptor","http://www.ncbi.nlm.nih.gov/gene/?term=1956","1956","13649",null,null,null,null,"P00533","Q01279","A0A8I5ZMJ2","A0A8I3NJD5","A0A286ZV23","A0A1D5QDK1","GO:0009925; GO:0016323; GO:0030054; GO:0009986; GO:0030669; GO:0005737; GO:0031901; GO:0030139; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0000139; GO:0097708; GO:0016020; GO:0045121; GO:0097489; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0032991; GO:0043235; GO:0032587; GO:0070435","GO:0051015; GO:0005524; GO:0051117; GO:0045296; GO:0003682; GO:0003690; GO:0019899; GO:0048408; GO:0005006; GO:0042802; GO:0016301; GO:0019900; GO:0004709; GO:0140677; GO:0030235; GO:0000166; GO:0016004; GO:0005515; GO:0004672; GO:0019903; GO:0030296; GO:0004713; GO:0016740; GO:0030297; GO:0004714; GO:0004888; GO:0031625; GO:0001618","GO:0007202; GO:0000902; GO:0008283; GO:0007166; GO:0098609; GO:0071230; GO:0071276; GO:0071364; GO:0071392; GO:0071363; GO:0034614; GO:0021795; GO:0048546; GO:0001892; GO:0007173; GO:0008544; GO:0050673; GO:0038127; GO:0038134; GO:0061029; GO:0001942; GO:0007611; GO:0000165; GO:0060571; GO:0043066; GO:1905208; GO:0042059; GO:0042177; GO:0022008; GO:0001503; GO:0038083; GO:0018108; GO:0016310; GO:0090263; GO:0030307; GO:0030335; GO:0008284; GO:0045737; GO:0045739; GO:0045740; GO:0045893; GO:0050679; GO:0070374; GO:0048146; GO:1900087; GO:0033674; GO:0043406; GO:1902895; GO:1901224; GO:0010750; GO:0033138; GO:0042327; GO:0051897; GO:1900020; GO:1903078; GO:0001934; GO:0045944; GO:0046777; GO:0051205; GO:0006468; GO:0042127; GO:0070372; GO:0046328; GO:0050999; GO:0050730; GO:0014066; GO:0070141; GO:0007435; GO:0007165; GO:0007169; GO:0046718","PTHR24416:SF91","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3236|UniProtKB=P00533","P06664; P00012; P00018"]
["EGF Receptor - phospho","Tyr992","EGFR","175","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0874",".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; EGF receptor signaling pathway","EPIDERMAL GROWTH FACTOR RECEPTOR","activation of phospholipase C activity; cell morphogenesis; cell population proliferation; cell surface receptor signaling pathway; cell-cell adhesion; cellular response to amino acid stimulus; cellular response to cadmium ion; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to growth factor stimulus; cellular response to reactive oxygen species; cerebral cortex cell migration; digestive tract morphogenesis; embryonic placenta development; epidermal growth factor receptor signaling pathway; epidermis development; epithelial cell proliferation; ERBB signaling pathway; ERBB2-EGFR signaling pathway; eyelid development in camera-type eye; hair follicle development; learning or memory; MAPK cascade; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of cardiocyte differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein catabolic process; neurogenesis; ossification; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of miRNA transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide mediated signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein kinase C activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein insertion into membrane; protein phosphorylation; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; response to UV-A; salivary gland morphogenesis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; viral entry into host cell","actin filament binding; ATP binding; ATPase binding; cadherin binding; chromatin binding; double-stranded DNA binding; enzyme binding; epidermal growth factor binding; epidermal growth factor receptor activity; identical protein binding; kinase activity; kinase binding; MAP kinase kinase kinase activity; molecular function activator activity; nitric-oxide synthase regulator activity; nucleotide binding; phospholipase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activator activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding; virus receptor activity","basal plasma membrane; basolateral plasma membrane; cell junction; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasm; early endosome membrane; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; intracellular vesicle; membrane; membrane raft; multivesicular body, internal vesicle lumen; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; protein-containing complex; receptor complex; ruffle membrane; Shc-EGFR complex","Tyrosine kinase / adaptor","epidermal growth factor receptor","http://www.ncbi.nlm.nih.gov/gene/?term=1956","1956","13649",null,null,null,null,"P00533","Q01279","A0A8I5ZMJ2","A0A8I3NJD5","A0A286ZV23","A0A1D5QDK1","GO:0009925; GO:0016323; GO:0030054; GO:0009986; GO:0030669; GO:0005737; GO:0031901; GO:0030139; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0005576; GO:0005615; GO:0005925; GO:0005794; GO:0000139; GO:0097708; GO:0016020; GO:0045121; GO:0097489; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0032991; GO:0043235; GO:0032587; GO:0070435","GO:0051015; GO:0005524; GO:0051117; GO:0045296; GO:0003682; GO:0003690; GO:0019899; GO:0048408; GO:0005006; GO:0042802; GO:0016301; GO:0019900; GO:0004709; GO:0140677; GO:0030235; GO:0000166; GO:0016004; GO:0005515; GO:0004672; GO:0019903; GO:0030296; GO:0004713; GO:0016740; GO:0030297; GO:0004714; GO:0004888; GO:0031625; GO:0001618","GO:0007202; GO:0000902; GO:0008283; GO:0007166; GO:0098609; GO:0071230; GO:0071276; GO:0071364; GO:0071392; GO:0071363; GO:0034614; GO:0021795; GO:0048546; GO:0001892; GO:0007173; GO:0008544; GO:0050673; GO:0038127; GO:0038134; GO:0061029; GO:0001942; GO:0007611; GO:0000165; GO:0060571; GO:0043066; GO:1905208; GO:0042059; GO:0042177; GO:0022008; GO:0001503; GO:0038083; GO:0018108; GO:0016310; GO:0090263; GO:0030307; GO:0030335; GO:0008284; GO:0045737; GO:0045739; GO:0045740; GO:0045893; GO:0050679; GO:0070374; GO:0048146; GO:1900087; GO:0033674; GO:0043406; GO:1902895; GO:1901224; GO:0010750; GO:0033138; GO:0042327; GO:0051897; GO:1900020; GO:1903078; GO:0001934; GO:0045944; GO:0046777; GO:0051205; GO:0006468; GO:0042127; GO:0070372; GO:0046328; GO:0050999; GO:0050730; GO:0014066; GO:0070141; GO:0007435; GO:0007165; GO:0007169; GO:0046718","PTHR24416:SF91","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3236|UniProtKB=P00533","P06664; P00012; P00018"]
["EGR1",null,"EGR1","75","rb",null,1.1000000000000001,1,4,4,4,4,"# 1226",".APO., .BMP., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .HIF., .IMUF., .INFM., .OP., .OPA., .OT., .SREME., .ST., .TCR., .TRASR., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin","EARLY GROWTH RESPONSE PROTEIN 1","BMP signaling pathway; cellular response to gamma radiation; cellular response to heparin; cellular response to interleukin-8; cellular response to mycophenolic acid; cellular response to organic substance; circadian regulation of gene expression; circadian temperature homeostasis; estrous cycle; glomerular mesangial cell proliferation; interleukin-1-mediated signaling pathway; locomotor rhythm; negative regulation of canonical Wnt signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of chemokine production; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of glomerular metanephric mesangial cell proliferation; positive regulation of hormone biosynthetic process; positive regulation of interleukin-1 beta production; positive regulation of miRNA transcription; positive regulation of neuron death; positive regulation of post-translational protein modification; positive regulation of tau-protein kinase activity; positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; regulation of DNA-templated transcription; regulation of progesterone biosynthetic process; regulation of protein sumoylation; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to hypoxia; response to glucose; response to hypoxia; response to insulin; response to ischemia; rhythmic process; skeletal muscle cell differentiation; T cell differentiation","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded methylated DNA binding; hemi-methylated DNA-binding; histone acetyltransferase binding; metal ion binding; promoter-specific chromatin binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; zinc ion binding","chromatin; cytoplasm; nucleoplasm; nucleus","Transcription factor","early growth response 1","http://www.ncbi.nlm.nih.gov/gene/?term=1958","1958","13653",null,"481528","100520726",null,"P18146","P08046","A0A0H2UHR3","A0A8I3PHY4","F1RH73",null,"GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0010385; GO:0044729; GO:0035035; GO:0046872; GO:1990841; GO:0005515; GO:0000978; GO:0000977; GO:0043565; GO:1990837; GO:0000976; GO:0008270","GO:0030509; GO:0071480; GO:0071504; GO:0098759; GO:0071506; GO:0071310; GO:0032922; GO:0060086; GO:0044849; GO:0072110; GO:0070498; GO:0045475; GO:0090090; GO:0000122; GO:0032722; GO:0045893; GO:0010628; GO:0072303; GO:0046886; GO:0032731; GO:1902895; GO:1901216; GO:1901875; GO:1902949; GO:0045944; GO:0042981; GO:0006355; GO:2000182; GO:0033233; GO:0006357; GO:0061418; GO:0009749; GO:0001666; GO:0032868; GO:0002931; GO:0048511; GO:0035914; GO:0030217","PTHR23235:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3238|UniProtKB=P18146","P06959; P06664; P05911"]
["eIF2 alpha",null,"EIF2S1","38","ms",null,2,1,2,2,2,2,"# 2164",".ALZ., .APH., .APO., .CD., .CSP., .DI., .OP., .OPA., .OT., .OXS., .SREME., .ST., .TRASR.","Apoptosis signaling pathway","EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1","aging; cellular response to amino acid starvation; cellular response to heat; cellular response to oxidative stress; cellular response to UV; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of translational initiation in response to stress; PERK-mediated unfolded protein response; positive regulation of neuron death; positive regulation of type B pancreatic cell apoptotic process; protein autophosphorylation; regulation of translation; regulation of translational initiation in response to stress; response to endoplasmic reticulum stress; response to manganese-induced endoplasmic reticulum stress; stress granule assembly; translation; translational initiation","nucleic acid binding; protein binding; ribosome binding; RNA binding; translation initiation factor activity","cytoplasm; cytoplasmic stress granule; cytosol; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 2 complex; eukaryotic translation initiation factor 2B complex; extracellular exosome; glial limiting end-foot; membrane; multi-eIF complex; nucleus; polysome; synapse; translation initiation ternary complex","Translational control","eukaryotic translation initiation factor 2 subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=1965","1965","13665","54318","480361",null,"710150","P05198","Q6ZWX6","P68101","A0A8I3MV19",null,"F7EFD7","GO:0005737; GO:0010494; GO:0005829; GO:0033290; GO:0005850; GO:0005851; GO:0070062; GO:0097451; GO:0016020; GO:0043614; GO:0005634; GO:0005844; GO:0045202; GO:0044207","GO:0003676; GO:0005515; GO:0043022; GO:0003723; GO:0003743","GO:0007568; GO:0034198; GO:0034605; GO:0034599; GO:0034644; GO:1905098; GO:0032057; GO:0036499; GO:1901216; GO:2000676; GO:0046777; GO:0006417; GO:0043558; GO:0034976; GO:1990737; GO:0034063; GO:0006412; GO:0006413","PTHR10602:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3265|UniProtKB=P05198","P00006"]
["eIF2 alpha - phospho","Ser51","EIF2S1","38","rb",null,1,1,1,2,2,8,"# 1204",".ALZ., .APH., .APO., .CD., .CSP., .DI., .OP., .OPA., .OT., .OXS., .SREME., .ST., .TRASR.","Apoptosis signaling pathway","EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1","aging; cellular response to amino acid starvation; cellular response to heat; cellular response to oxidative stress; cellular response to UV; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of translational initiation in response to stress; PERK-mediated unfolded protein response; positive regulation of neuron death; positive regulation of type B pancreatic cell apoptotic process; protein autophosphorylation; regulation of translation; regulation of translational initiation in response to stress; response to endoplasmic reticulum stress; response to manganese-induced endoplasmic reticulum stress; stress granule assembly; translation; translational initiation","nucleic acid binding; protein binding; ribosome binding; RNA binding; translation initiation factor activity","cytoplasm; cytoplasmic stress granule; cytosol; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 2 complex; eukaryotic translation initiation factor 2B complex; extracellular exosome; glial limiting end-foot; membrane; multi-eIF complex; nucleus; polysome; synapse; translation initiation ternary complex","Translational control","eukaryotic translation initiation factor 2 subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=1965","1965","13665","54318","480361",null,"710150","P05198","Q6ZWX6","P68101","A0A8I3MV19",null,"F7EFD7","GO:0005737; GO:0010494; GO:0005829; GO:0033290; GO:0005850; GO:0005851; GO:0070062; GO:0097451; GO:0016020; GO:0043614; GO:0005634; GO:0005844; GO:0045202; GO:0044207","GO:0003676; GO:0005515; GO:0043022; GO:0003723; GO:0003743","GO:0007568; GO:0034198; GO:0034605; GO:0034599; GO:0034644; GO:1905098; GO:0032057; GO:0036499; GO:1901216; GO:2000676; GO:0046777; GO:0006417; GO:0043558; GO:0034976; GO:1990737; GO:0034063; GO:0006412; GO:0006413","PTHR10602:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3265|UniProtKB=P05198","P00006"]
["eIF4B",null,"EIF4B","80","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2189",".CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OP., .OT., .PI3K., .RTK., .TRASR.",null,"EUKARYOTIC TRANSLATION INITIATION FACTOR 4B","eukaryotic translation initiation factor 4F complex assembly; formation of translation preinitiation complex; regulation of translational initiation; translation; translational initiation","nucleic acid binding; protein binding; ribosomal small subunit binding; RNA binding; RNA strand annealing activity; RNA strand-exchange activity; translation initiation factor activity","cytosol; eukaryotic translation initiation factor 4F complex",null,"eukaryotic translation initiation factor 4B","http://www.ncbi.nlm.nih.gov/gene/?term=1975","1975","75705",null,null,null,null,"P23588","Q8BGD9",null,"A0A8I3PJS8",null,null,"GO:0005829; GO:0016281","GO:0003676; GO:0005515; GO:0043024; GO:0003723; GO:0033592; GO:0034057; GO:0003743","GO:0097010; GO:0001731; GO:0006446; GO:0006412; GO:0006413","PTHR23236:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3285|UniProtKB=P23588"]
["eIF4B - phospho","Ser406","EIF4B","80","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2356",".CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OP., .OT., .PI3K., .RTK., .TRASR.",null,"EUKARYOTIC TRANSLATION INITIATION FACTOR 4B","eukaryotic translation initiation factor 4F complex assembly; formation of translation preinitiation complex; regulation of translational initiation; translation; translational initiation","nucleic acid binding; protein binding; ribosomal small subunit binding; RNA binding; RNA strand annealing activity; RNA strand-exchange activity; translation initiation factor activity","cytosol; eukaryotic translation initiation factor 4F complex",null,"eukaryotic translation initiation factor 4B","http://www.ncbi.nlm.nih.gov/gene/?term=1975","1975","75705",null,null,null,null,"P23588","Q8BGD9",null,"A0A8I3PJS8",null,null,"GO:0005829; GO:0016281","GO:0003676; GO:0005515; GO:0043024; GO:0003723; GO:0033592; GO:0034057; GO:0003743","GO:0097010; GO:0001731; GO:0006446; GO:0006412; GO:0006413","PTHR23236:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3285|UniProtKB=P23588"]
["eIF4B - phospho","Ser422","EIF4B","80","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2188",".CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OP., .OT., .PI3K., .RTK., .TRASR.",null,"EUKARYOTIC TRANSLATION INITIATION FACTOR 4B","eukaryotic translation initiation factor 4F complex assembly; formation of translation preinitiation complex; regulation of translational initiation; translation; translational initiation","nucleic acid binding; protein binding; ribosomal small subunit binding; RNA binding; RNA strand annealing activity; RNA strand-exchange activity; translation initiation factor activity","cytosol; eukaryotic translation initiation factor 4F complex",null,"eukaryotic translation initiation factor 4B","http://www.ncbi.nlm.nih.gov/gene/?term=1975","1975","75705",null,null,null,null,"P23588","Q8BGD9",null,"A0A8I3PJS8",null,null,"GO:0005829; GO:0016281","GO:0003676; GO:0005515; GO:0043024; GO:0003723; GO:0033592; GO:0034057; GO:0003743","GO:0097010; GO:0001731; GO:0006446; GO:0006412; GO:0006413","PTHR23236:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3285|UniProtKB=P23588"]
["eIF4E",null,"EIF4E","25","rb",null,1,1,1,2,2,1,"# 1860",".APH., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .PI3K., .RTK., .SREME., .TRASR.","CCKR signaling map; p38 MAPK pathway","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E","behavioral fear response; cellular response to dexamethasone stimulus; G1/S transition of mitotic cell cycle; negative regulation of autophagy; negative regulation of neuron differentiation; negative regulation of translation; neuron differentiation; positive regulation of mitotic cell cycle; regulation of translation; regulation of translation at postsynapse, modulating synaptic transmission; stem cell population maintenance; translation; translational initiation","DNA-binding transcription factor binding; enzyme binding; eukaryotic initiation factor 4G binding; protein binding; RNA 7-methylguanosine cap binding; RNA binding; RNA cap binding; translation initiation factor activity; translation regulator activity","chromatoid body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic stress granule; cytosol; eukaryotic translation initiation factor 4F complex; extracellular exosome; glutamatergic synapse; mRNA cap binding complex; nucleus; P-body; perinuclear region of cytoplasm; postsynapse; RISC complex","Translational control","eukaryotic translation initiation factor 4E","http://www.ncbi.nlm.nih.gov/gene/?term=1977","1977","13684","117045",null,"100038030",null,"P06730","P63073","P63074","A0A8I3S7T5","A0A5G2RC36","F7GKR8","GO:0033391; GO:0005737; GO:0036464; GO:0010494; GO:0005829; GO:0016281; GO:0070062; GO:0098978; GO:0005845; GO:0005634; GO:0000932; GO:0048471; GO:0098794; GO:0016442","GO:0140297; GO:0019899; GO:0031370; GO:0005515; GO:0000340; GO:0003723; GO:0000339; GO:0003743; GO:0045182","GO:0001662; GO:0071549; GO:0000082; GO:0010507; GO:0045665; GO:0017148; GO:0030182; GO:0045931; GO:0006417; GO:0099578; GO:0019827; GO:0006412; GO:0006413","PTHR11960:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3287|UniProtKB=P06730","P06959; P05918"]
["eIF4E - phospho","Ser209","EIF4E","25","rb",null,1,1.1000000000000001,1,8,1.1000000000000001,1.1000000000000001,"# 1904",".APH., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .PI3K., .RTK., .SREME., .TRASR.","CCKR signaling map; p38 MAPK pathway","EUKARYOTIC TRANSLATION INITIATION FACTOR 4E","behavioral fear response; cellular response to dexamethasone stimulus; G1/S transition of mitotic cell cycle; negative regulation of autophagy; negative regulation of neuron differentiation; negative regulation of translation; neuron differentiation; positive regulation of mitotic cell cycle; regulation of translation; regulation of translation at postsynapse, modulating synaptic transmission; stem cell population maintenance; translation; translational initiation","DNA-binding transcription factor binding; enzyme binding; eukaryotic initiation factor 4G binding; protein binding; RNA 7-methylguanosine cap binding; RNA binding; RNA cap binding; translation initiation factor activity; translation regulator activity","chromatoid body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic stress granule; cytosol; eukaryotic translation initiation factor 4F complex; extracellular exosome; glutamatergic synapse; mRNA cap binding complex; nucleus; P-body; perinuclear region of cytoplasm; postsynapse; RISC complex","Translational control","eukaryotic translation initiation factor 4E","http://www.ncbi.nlm.nih.gov/gene/?term=1977","1977","13684","117045",null,"100038030",null,"P06730","P63073","P63074","A0A8I3S7T5","A0A5G2RC36","F7GKR8","GO:0033391; GO:0005737; GO:0036464; GO:0010494; GO:0005829; GO:0016281; GO:0070062; GO:0098978; GO:0005845; GO:0005634; GO:0000932; GO:0048471; GO:0098794; GO:0016442","GO:0140297; GO:0019899; GO:0031370; GO:0005515; GO:0000340; GO:0003723; GO:0000339; GO:0003743; GO:0045182","GO:0001662; GO:0071549; GO:0000082; GO:0010507; GO:0045665; GO:0017148; GO:0030182; GO:0045931; GO:0006417; GO:0099578; GO:0019827; GO:0006412; GO:0006413","PTHR11960:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3287|UniProtKB=P06730","P06959; P05918"]
["Elk-1",null,"ELK1","46","rb",null,2,2,2,8,1.1000000000000001,2.1,"# 2160",".CANCER., .CANPTHW., .CCKR., .CSP., .CUR., .D100., .D200., .D300., .DI., .DRAS., .EGFR., .EMC., .HEPB., .IMUF., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .PARK., .PDGF., .RAS., .RTK., .SREME., .TOLL., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p38 MAPK pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Ras Pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response","ETS DOMAIN-CONTAINING PROTEIN ELK-1","cell differentiation; cellular response to gamma radiation; cellular response to lipid; cellular response to testosterone stimulus; gene expression; liver development; lung development; positive regulation of DNA-templated transcription; positive regulation of neuron death; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to fibroblast growth factor; response to light stimulus","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; nuclear receptor coactivator activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","axon terminus; chromatin; cytoplasm; dendrite; mitochondrion; neuronal cell body; nucleoplasm; nucleus","MAPK signaling","ETS transcription factor ELK1","http://www.ncbi.nlm.nih.gov/gene/?term=2002","2002","13712","314436",null,null,"712610","P19419","P41969","A4GTP4","A0A8I3Q408",null,"F6R9C9","GO:0043679; GO:0000785; GO:0005737; GO:0030425; GO:0005739; GO:0043025; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0003690; GO:0030374; GO:0005515; GO:0000978; GO:0061629; GO:0043565; GO:1990837; GO:0000976","GO:0030154; GO:0071480; GO:0071396; GO:0071394; GO:0010467; GO:0001889; GO:0030324; GO:0045893; GO:1901216; GO:0045944; GO:0006355; GO:0006357; GO:0071774; GO:0009416","PTHR11849:SF178","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3321|UniProtKB=P19419","P06959; P00032; P05918; P00036; P06664; P04393; P00047; P05911; P00054; P00049; P00046"]
["Elk-1 - phospho","Ser383","ELK1","47","ms",null,2,7,4,4,4,4,"# 1826",".CANCER., .CANPTHW., .CCKR., .CSP., .CUR., .D100., .D200., .D300., .DI., .DRAS., .EGFR., .EMC., .HEPB., .IMUF., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .PARK., .PDGF., .RAS., .RTK., .SREME., .TOLL., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p38 MAPK pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Ras Pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response","ETS DOMAIN-CONTAINING PROTEIN ELK-1","cell differentiation; cellular response to gamma radiation; cellular response to lipid; cellular response to testosterone stimulus; gene expression; liver development; lung development; positive regulation of DNA-templated transcription; positive regulation of neuron death; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to fibroblast growth factor; response to light stimulus","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; nuclear receptor coactivator activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","axon terminus; chromatin; cytoplasm; dendrite; mitochondrion; neuronal cell body; nucleoplasm; nucleus","MAPK signaling","ETS transcription factor ELK1","http://www.ncbi.nlm.nih.gov/gene/?term=2002","2002","13712","314436",null,null,"712610","P19419","P41969","A4GTP4","A0A8I3Q408",null,"F6R9C9","GO:0043679; GO:0000785; GO:0005737; GO:0030425; GO:0005739; GO:0043025; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0003690; GO:0030374; GO:0005515; GO:0000978; GO:0061629; GO:0043565; GO:1990837; GO:0000976","GO:0030154; GO:0071480; GO:0071396; GO:0071394; GO:0010467; GO:0001889; GO:0030324; GO:0045893; GO:1901216; GO:0045944; GO:0006355; GO:0006357; GO:0071774; GO:0009416","PTHR11849:SF178","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3321|UniProtKB=P19419","P06959; P00032; P05918; P00036; P06664; P04393; P00047; P05911; P00054; P00049; P00046"]
["EMSY",null,"EMSY","141","rb",null,2,1,8,1.1000000000000001,1,8,"# 1388",".CD., .CSP., .DDR., .DREP., .OP., .OT., .TRASR.",null,"BRCA2-INTERACTING TRANSCRIPTIONAL REPRESSOR EMSY","cellular response to DNA damage stimulus; chromatin organization; DNA repair; regulation of DNA-templated transcription","protein binding","nucleoplasm; nucleus","DNA damage","EMSY transcriptional repressor, BRCA2 interacting","http://www.ncbi.nlm.nih.gov/gene/?term=56946","56946","233545",null,null,null,null,"Q7Z589","Q8BMB0","A0A8I5YCB7","A0A8P0P9M4","A0A286ZLC9","A0A1D5QCT4","GO:0005654; GO:0005634","GO:0005515","GO:0006974; GO:0006325; GO:0006281; GO:0006355","PTHR16500:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18071|UniProtKB=Q7Z589"]
["Endothelin A receptor",null,"EDNRA","49","rb",null,1,2,8,8,2.1,2.1,"# 1415",".ANG., .APO., .cAMP., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .ENDO., .GPCR., .GPROT., .HIF., .IMUF., .MIG., .NFKB., .OP., .OPA., .OT., .OXS., .SREME., .ST., .WNT.","Endothelin signaling pathway","ENDOTHELIN-1 RECEPTOR","activation of adenylate cyclase activity; activation of phospholipase C activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; angiogenesis; aorta development; artery smooth muscle contraction; atrial cardiac muscle tissue development; axon extension; axon guidance; axonogenesis involved in innervation; blood circulation; blood vessel remodeling; branching involved in blood vessel morphogenesis; calcium ion transmembrane transport; canonical Wnt signaling pathway; cardiac chamber formation; cardiac neural crest cell migration involved in outflow tract morphogenesis; cell population proliferation; cellular calcium ion homeostasis; cellular response to follicle-stimulating hormone stimulus; cellular response to human chorionic gonadotropin stimulus; cellular response to luteinizing hormone stimulus; cellular response to organic substance; cellular response to oxidative stress; cranial skeletal system development; developmental pigmentation; embryonic heart tube development; embryonic skeletal system development; endothelin receptor signaling pathway; endothelin receptor signaling pathway involved in heart process; enteric nervous system development; establishment of endothelial barrier; face development; G protein-coupled receptor signaling pathway; gene expression; glomerular endothelium development; glomerular filtration; glomerulus development; head development; heart development; heparin metabolic process; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; intracellular signal transduction; left ventricular cardiac muscle tissue morphogenesis; meiotic cell cycle process involved in oocyte maturation; mesenchymal cell apoptotic process; middle ear morphogenesis; mitochondrion organization; mitotic cell cycle; multicellular organism aging; neural crest cell development; neural crest cell differentiation; neural crest cell fate commitment; neuromuscular process; neuron projection development; neuron remodeling; noradrenergic neuron differentiation; norepinephrine metabolic process; pharyngeal arch artery morphogenesis; podocyte apoptotic process; podocyte differentiation; positive regulation of cation channel activity; positive regulation of cytosolic calcium ion concentration; protein kinase A signaling; protein phosphorylation; protein transmembrane transport; regulation of biological quality; regulation of blood pressure; regulation of glucose transmembrane transport; regulation of heart rate; regulation of protein localization to cell leading edge; renal albumin absorption; renal sodium ion absorption; respiratory gaseous exchange by respiratory system; response to acetylcholine; response to amphetamine; response to hypoxia; response to organic substance; response to wounding; semaphorin-plexin signaling pathway involved in axon guidance; signal transduction; smooth muscle contraction; sodium ion homeostasis; sympathetic nervous system development; sympathetic neuron axon guidance; thyroid gland development; vascular associated smooth muscle cell development; vasoconstriction","endothelin receptor activity; G protein-coupled receptor activity; phosphatidylinositol phospholipase C activity; protein binding","cell periphery; membrane; plasma membrane","Cell membrane","endothelin receptor type A","http://www.ncbi.nlm.nih.gov/gene/?term=1909","1909","13617","24326",null,null,null,"P25101","Q61614","A0A0G2JSX5","A0A8I3NSA0","A0A5G2QII3","F7HSF3","GO:0071944; GO:0016020; GO:0005886","GO:0004962; GO:0004930; GO:0004435; GO:0005515","GO:0007190; GO:0007202; GO:0007193; GO:0001525; GO:0035904; GO:0014824; GO:0003228; GO:0048675; GO:0007411; GO:0060385; GO:0008015; GO:0001974; GO:0001569; GO:0070588; GO:0060070; GO:0003207; GO:0003253; GO:0008283; GO:0006874; GO:0071372; GO:0044751; GO:0071373; GO:0071310; GO:0034599; GO:1904888; GO:0048066; GO:0035050; GO:0048706; GO:0086100; GO:0086101; GO:0048484; GO:0061028; GO:0060324; GO:0007186; GO:0010467; GO:0072011; GO:0003094; GO:0032835; GO:0060322; GO:0007507; GO:0030202; GO:0007249; GO:0001701; GO:0035556; GO:0003220; GO:1903537; GO:0097152; GO:0042474; GO:0007005; GO:0000278; GO:0010259; GO:0014032; GO:0014033; GO:0014034; GO:0050905; GO:0031175; GO:0016322; GO:0003357; GO:0042415; GO:0061626; GO:1903210; GO:0072112; GO:2001259; GO:0007204; GO:0010737; GO:0006468; GO:0071806; GO:0065008; GO:0008217; GO:0010827; GO:0002027; GO:1905871; GO:0097018; GO:0070294; GO:0007585; GO:1905144; GO:0001975; GO:0001666; GO:0010033; GO:0009611; GO:1902287; GO:0007165; GO:0006939; GO:0055078; GO:0048485; GO:0097492; GO:0030878; GO:0097084; GO:0042310","PTHR46099:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3179|UniProtKB=P25101","P00019"]
["Eotaxin",null,"CCL11","11","rb",null,7,6,"n/a","n/a","n/a","n/a","# 1396",".ANG., .CANCER., .CCP., .CD., .CP., .CSP., .GPCR., .GPROT., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .ST., .TNF., .VIR.","Inflammation mediated by chemokine and cytokine signaling pathway","EOTAXIN","actin filament organization; branching involved in mammary gland duct morphogenesis; cell adhesion; cellular calcium ion homeostasis; cellular response to interleukin-1; cellular response to tumor necrosis factor; cellular response to type II interferon; chemokine-mediated signaling pathway; chemotaxis; chronic inflammatory response; cytoskeleton organization; eosinophil chemotaxis; ERK1 and ERK2 cascade; G protein-coupled receptor signaling pathway; immune response; inflammatory response; learning or memory; lymphocyte chemotaxis; mammary duct terminal end bud growth; mast cell chemotaxis; monocyte chemotaxis; negative regulation of neurogenesis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; protein phosphorylation; regulation of cell shape; response to interleukin-13; response to interleukin-4; response to radiation; response to virus; signal transduction","CCR chemokine receptor binding; CCR3 chemokine receptor binding; chemokine activity; cytokine activity; protein binding; protein dimerization activity; receptor ligand activity","extracellular region; extracellular space","Immunology","C-C motif chemokine ligand 11","http://www.ncbi.nlm.nih.gov/gene/?term=6356","6356","20292","29397",null,null,null,"P51671","P48298","P97545",null,null,null,"GO:0005576; GO:0005615","GO:0048020; GO:0031728; GO:0008009; GO:0005125; GO:0005515; GO:0046983; GO:0048018","GO:0007015; GO:0060444; GO:0007155; GO:0006874; GO:0071347; GO:0071356; GO:0071346; GO:0070098; GO:0006935; GO:0002544; GO:0007010; GO:0048245; GO:0070371; GO:0007186; GO:0006955; GO:0006954; GO:0007611; GO:0048247; GO:0060763; GO:0002551; GO:0002548; GO:0050768; GO:0030593; GO:0030838; GO:0045766; GO:0030335; GO:0001938; GO:0070374; GO:0043547; GO:0006468; GO:0008360; GO:0035962; GO:0070670; GO:0009314; GO:0009615; GO:0007165","PTHR12015:SF146","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10610|UniProtKB=P51671","P00031"]
["EpCAM",null,"EPCAM","40","rb",null,1.1000000000000001,4,1,8,8,8,"# 0454",".CCP., .CP., .CSP., .OP., .OPA., .OT., .ST., .TRASR.",null,"EPITHELIAL CELL ADHESION MOLECULE","cell-cell adhesion; negative regulation of cell-cell adhesion mediated by cadherin; positive regulation of cell population proliferation; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; signal transduction involved in regulation of gene expression; stem cell differentiation; ureteric bud development","cadherin binding involved in cell-cell adhesion; protein binding; protein-containing complex binding","anchoring junction; apical plasma membrane; basolateral plasma membrane; bicellular tight junction; cell surface; extracellular exosome; lateral plasma membrane; membrane; plasma membrane","Cytoskeletal regulation / Adhesion","epithelial cell adhesion molecule","http://www.ncbi.nlm.nih.gov/gene/?term=4072","4072","17075","171577",null,"403163","677680","P16422","Q99JW5","O55159","A0A8I3MNS0","Q75QW1","Q1WER1","GO:0070161; GO:0016324; GO:0016323; GO:0005923; GO:0009986; GO:0070062; GO:0016328; GO:0016020; GO:0005886","GO:0098641; GO:0005515; GO:0044877","GO:0098609; GO:2000048; GO:0008284; GO:2000648; GO:0045944; GO:0023019; GO:0048863; GO:0001657","PTHR14168:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11529|UniProtKB=P16422"]
["EpCAM",null,"EPCAM","40","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1984",".CCP., .CP., .CSP., .OP., .OPA., .OT., .ST., .TRASR.",null,"EPITHELIAL CELL ADHESION MOLECULE","cell-cell adhesion; negative regulation of cell-cell adhesion mediated by cadherin; positive regulation of cell population proliferation; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; signal transduction involved in regulation of gene expression; stem cell differentiation; ureteric bud development","cadherin binding involved in cell-cell adhesion; protein binding; protein-containing complex binding","anchoring junction; apical plasma membrane; basolateral plasma membrane; bicellular tight junction; cell surface; extracellular exosome; lateral plasma membrane; membrane; plasma membrane","Cytoskeletal regulation / Adhesion","epithelial cell adhesion molecule","http://www.ncbi.nlm.nih.gov/gene/?term=4072","4072","17075","171577",null,"403163","677680","P16422","Q99JW5","O55159","A0A8I3MNS0","Q75QW1","Q1WER1","GO:0070161; GO:0016324; GO:0016323; GO:0005923; GO:0009986; GO:0070062; GO:0016328; GO:0016020; GO:0005886","GO:0098641; GO:0005515; GO:0044877","GO:0098609; GO:2000048; GO:0008284; GO:2000648; GO:0045944; GO:0023019; GO:0048863; GO:0001657","PTHR14168:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11529|UniProtKB=P16422"]
["EphA2",null,"EPHA2","125","rb",null,2,4,8,8,1.1000000000000001,1.1000000000000001,"# 1321",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DDR., .IMFR., .IMUR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VIR.",null,"EPHRIN TYPE-A RECEPTOR 2","activation of GTPase activity; angiogenesis; apoptotic process; axial mesoderm formation; axon guidance; blood vessel development; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; blood vessel morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; cAMP metabolic process; cell adhesion; cell chemotaxis; cell differentiation; cell migration; cell motility; defense response to Gram-positive bacterium; ephrin receptor signaling pathway; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; keratinocyte differentiation; lens fiber cell morphogenesis; mammary gland epithelial cell proliferation; negative regulation of angiogenesis; negative regulation of chemokine production; negative regulation of cytokine production; negative regulation of lymphangiogenesis; negative regulation of protein kinase B signaling; neural tube development; neuron differentiation; notochord cell development; notochord formation; notochord morphogenesis; osteoblast differentiation; osteoclast differentiation; peptidyl-tyrosine phosphorylation; pericyte cell differentiation; phosphorylation; positive regulation of bicellular tight junction assembly; positive regulation of cell migration; positive regulation of kinase activity; positive regulation of protein localization to plasma membrane; post-anal tail morphogenesis; protein kinase B signaling; protein localization to plasma membrane; protein phosphorylation; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of cell adhesion mediated by integrin; regulation of ERK1 and ERK2 cascade; regulation of lamellipodium assembly; response to growth factor; skeletal system development; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis; viral entry into host cell","ATP binding; cadherin binding; ephrin receptor activity; growth factor binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity; virus receptor activity","anchoring junction; cell projection; cell surface; focal adhesion; lamellipodium; lamellipodium membrane; leading edge membrane; membrane; neuron projection; plasma membrane; receptor complex; ruffle membrane; tight junction",null,"EPH receptor A2","http://www.ncbi.nlm.nih.gov/gene/?term=1969","1969","13836",null,null,"100522873",null,"P29317","Q03145","A0A8I5ZQ88","A0A8I3MVS4","F1SUT8","A0A1D5QYU6","GO:0070161; GO:0042995; GO:0009986; GO:0005925; GO:0030027; GO:0031258; GO:0031256; GO:0016020; GO:0043005; GO:0005886; GO:0043235; GO:0032587; GO:0070160","GO:0005524; GO:0045296; GO:0005003; GO:0019838; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0005005; GO:0001618","GO:0090630; GO:0001525; GO:0006915; GO:0048320; GO:0007411; GO:0001568; GO:0002043; GO:0048514; GO:0046849; GO:0060444; GO:0046058; GO:0007155; GO:0060326; GO:0030154; GO:0016477; GO:0048870; GO:0050830; GO:0048013; GO:0006954; GO:0008630; GO:0030216; GO:0070309; GO:0033598; GO:0016525; GO:0032682; GO:0001818; GO:1901491; GO:0051898; GO:0021915; GO:0030182; GO:0060035; GO:0014028; GO:0048570; GO:0001649; GO:0030316; GO:0018108; GO:1904238; GO:0016310; GO:1903348; GO:0030335; GO:0033674; GO:1903078; GO:0036342; GO:0043491; GO:0072659; GO:0006468; GO:0045765; GO:0043535; GO:0033628; GO:0070372; GO:0010591; GO:0070848; GO:0001501; GO:0007169; GO:0001570; GO:0046718","PTHR24416:SF306","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3386|UniProtKB=P29317"]
["EphA2 - phospho","Ser897","EPHA2","125","rb",null,2.1,4,4,4,4,4,"# 1324",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DDR., .IMFR., .IMUR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VIR.",null,"EPHRIN TYPE-A RECEPTOR 2","activation of GTPase activity; angiogenesis; apoptotic process; axial mesoderm formation; axon guidance; blood vessel development; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; blood vessel morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; cAMP metabolic process; cell adhesion; cell chemotaxis; cell differentiation; cell migration; cell motility; defense response to Gram-positive bacterium; ephrin receptor signaling pathway; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; keratinocyte differentiation; lens fiber cell morphogenesis; mammary gland epithelial cell proliferation; negative regulation of angiogenesis; negative regulation of chemokine production; negative regulation of cytokine production; negative regulation of lymphangiogenesis; negative regulation of protein kinase B signaling; neural tube development; neuron differentiation; notochord cell development; notochord formation; notochord morphogenesis; osteoblast differentiation; osteoclast differentiation; peptidyl-tyrosine phosphorylation; pericyte cell differentiation; phosphorylation; positive regulation of bicellular tight junction assembly; positive regulation of cell migration; positive regulation of kinase activity; positive regulation of protein localization to plasma membrane; post-anal tail morphogenesis; protein kinase B signaling; protein localization to plasma membrane; protein phosphorylation; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of cell adhesion mediated by integrin; regulation of ERK1 and ERK2 cascade; regulation of lamellipodium assembly; response to growth factor; skeletal system development; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis; viral entry into host cell","ATP binding; cadherin binding; ephrin receptor activity; growth factor binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity; virus receptor activity","anchoring junction; cell projection; cell surface; focal adhesion; lamellipodium; lamellipodium membrane; leading edge membrane; membrane; neuron projection; plasma membrane; receptor complex; ruffle membrane; tight junction",null,"EPH receptor A2","http://www.ncbi.nlm.nih.gov/gene/?term=1969","1969","13836",null,null,"100522873",null,"P29317","Q03145","A0A8I5ZQ88","A0A8I3MVS4","F1SUT8","A0A1D5QYU6","GO:0070161; GO:0042995; GO:0009986; GO:0005925; GO:0030027; GO:0031258; GO:0031256; GO:0016020; GO:0043005; GO:0005886; GO:0043235; GO:0032587; GO:0070160","GO:0005524; GO:0045296; GO:0005003; GO:0019838; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0005005; GO:0001618","GO:0090630; GO:0001525; GO:0006915; GO:0048320; GO:0007411; GO:0001568; GO:0002043; GO:0048514; GO:0046849; GO:0060444; GO:0046058; GO:0007155; GO:0060326; GO:0030154; GO:0016477; GO:0048870; GO:0050830; GO:0048013; GO:0006954; GO:0008630; GO:0030216; GO:0070309; GO:0033598; GO:0016525; GO:0032682; GO:0001818; GO:1901491; GO:0051898; GO:0021915; GO:0030182; GO:0060035; GO:0014028; GO:0048570; GO:0001649; GO:0030316; GO:0018108; GO:1904238; GO:0016310; GO:1903348; GO:0030335; GO:0033674; GO:1903078; GO:0036342; GO:0043491; GO:0072659; GO:0006468; GO:0045765; GO:0043535; GO:0033628; GO:0070372; GO:0010591; GO:0070848; GO:0001501; GO:0007169; GO:0001570; GO:0046718","PTHR24416:SF306","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3386|UniProtKB=P29317"]
["EphA2 - phospho","Tyr594","EPHA2","135","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1312",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DDR., .IMFR., .IMUR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VIR.",null,"EPHRIN TYPE-A RECEPTOR 2","activation of GTPase activity; angiogenesis; apoptotic process; axial mesoderm formation; axon guidance; blood vessel development; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; blood vessel morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; cAMP metabolic process; cell adhesion; cell chemotaxis; cell differentiation; cell migration; cell motility; defense response to Gram-positive bacterium; ephrin receptor signaling pathway; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; keratinocyte differentiation; lens fiber cell morphogenesis; mammary gland epithelial cell proliferation; negative regulation of angiogenesis; negative regulation of chemokine production; negative regulation of cytokine production; negative regulation of lymphangiogenesis; negative regulation of protein kinase B signaling; neural tube development; neuron differentiation; notochord cell development; notochord formation; notochord morphogenesis; osteoblast differentiation; osteoclast differentiation; peptidyl-tyrosine phosphorylation; pericyte cell differentiation; phosphorylation; positive regulation of bicellular tight junction assembly; positive regulation of cell migration; positive regulation of kinase activity; positive regulation of protein localization to plasma membrane; post-anal tail morphogenesis; protein kinase B signaling; protein localization to plasma membrane; protein phosphorylation; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of cell adhesion mediated by integrin; regulation of ERK1 and ERK2 cascade; regulation of lamellipodium assembly; response to growth factor; skeletal system development; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis; viral entry into host cell","ATP binding; cadherin binding; ephrin receptor activity; growth factor binding; kinase activity; molecular function activator activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity; virus receptor activity","anchoring junction; cell projection; cell surface; focal adhesion; lamellipodium; lamellipodium membrane; leading edge membrane; membrane; neuron projection; plasma membrane; receptor complex; ruffle membrane; tight junction",null,"EPH receptor A2","http://www.ncbi.nlm.nih.gov/gene/?term=1969","1969","13836",null,null,"100522873",null,"P29317","Q03145","A0A8I5ZQ88","A0A8I3MVS4","F1SUT8","A0A1D5QYU6","GO:0070161; GO:0042995; GO:0009986; GO:0005925; GO:0030027; GO:0031258; GO:0031256; GO:0016020; GO:0043005; GO:0005886; GO:0043235; GO:0032587; GO:0070160","GO:0005524; GO:0045296; GO:0005003; GO:0019838; GO:0016301; GO:0140677; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0005005; GO:0001618","GO:0090630; GO:0001525; GO:0006915; GO:0048320; GO:0007411; GO:0001568; GO:0002043; GO:0048514; GO:0046849; GO:0060444; GO:0046058; GO:0007155; GO:0060326; GO:0030154; GO:0016477; GO:0048870; GO:0050830; GO:0048013; GO:0006954; GO:0008630; GO:0030216; GO:0070309; GO:0033598; GO:0016525; GO:0032682; GO:0001818; GO:1901491; GO:0051898; GO:0021915; GO:0030182; GO:0060035; GO:0014028; GO:0048570; GO:0001649; GO:0030316; GO:0018108; GO:1904238; GO:0016310; GO:1903348; GO:0030335; GO:0033674; GO:1903078; GO:0036342; GO:0043491; GO:0072659; GO:0006468; GO:0045765; GO:0043535; GO:0033628; GO:0070372; GO:0010591; GO:0070848; GO:0001501; GO:0007169; GO:0001570; GO:0046718","PTHR24416:SF306","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3386|UniProtKB=P29317"]
["EphA4",null,"EPHA4","110","rb",null,2,2,7,7,4,7,"# 1330",".CCP., .CP., .CSP., .HIF., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .SREME., .ST.",null,"EPHRIN TYPE-A RECEPTOR 4","adherens junction organization; adult walking behavior; axon guidance; cell adhesion; cellular response to amyloid-beta; cochlea development; corticospinal tract morphogenesis; ephrin receptor signaling pathway; fasciculation of motor neuron axon; fasciculation of sensory neuron axon; glial cell migration; motor neuron axon guidance; negative regulation of axon regeneration; negative regulation of cell adhesion; negative regulation of cell migration; negative regulation of cellular response to hypoxia; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of long-term synaptic potentiation; negative regulation of neuron projection development; negative regulation of proteolysis involved in protein catabolic process; nephric duct morphogenesis; nervous system development; neuron projection fasciculation; neuron projection guidance; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of amyloid-beta formation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of dendrite morphogenesis; positive regulation of JUN kinase activity; positive regulation of kinase activity; positive regulation of protein tyrosine kinase activity; positive regulation of Rho guanyl-nucleotide exchange factor activity; protein autophosphorylation; protein phosphorylation; protein stabilization; regulation of astrocyte differentiation; regulation of axonogenesis; regulation of dendritic spine morphogenesis; regulation of GTPase activity; regulation of modification of synaptic structure; regulation of synapse pruning; synapse pruning; transmembrane receptor protein tyrosine kinase signaling pathway","amyloid-beta binding; ATP binding; DH domain binding; ephrin receptor activity; ephrin receptor binding; GPI-linked ephrin receptor activity; identical protein binding; kinase activity; nucleotide binding; PH domain binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity","adherens junction; anchoring junction; axon; axon terminus; axonal growth cone; cell body; cell projection; cell surface; cytoplasm; dendrite; dendritic shaft; dendritic spine; early endosome; early endosome membrane; endoplasmic reticulum; endosome; filopodium; glutamatergic synapse; Golgi apparatus; membrane; mitochondrial outer membrane; neuromuscular junction; neuron projection; perikaryon; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; receptor complex; Schaffer collateral - CA1 synapse; synapse","Tyrosine kinase / adaptor","EPH receptor A4","http://www.ncbi.nlm.nih.gov/gene/?term=2043","2043","13838","316539",null,null,null,"P54764","Q03137","D3ZZK3","A0A8I3P796","A0A5G2QLV5","A0A1D5QL11","GO:0005912; GO:0070161; GO:0030424; GO:0043679; GO:0044295; GO:0044297; GO:0042995; GO:0009986; GO:0005737; GO:0030425; GO:0043198; GO:0043197; GO:0005769; GO:0031901; GO:0005783; GO:0005768; GO:0030175; GO:0098978; GO:0005794; GO:0016020; GO:0005741; GO:0031594; GO:0043005; GO:0043204; GO:0005886; GO:0014069; GO:0098839; GO:0045211; GO:0042734; GO:0043235; GO:0098685; GO:0045202","GO:0001540; GO:0005524; GO:0097161; GO:0005003; GO:0046875; GO:0005004; GO:0042802; GO:0016301; GO:0000166; GO:0042731; GO:0005515; GO:0004672; GO:0004713; GO:1990782; GO:0016740; GO:0004714; GO:0005005","GO:0034332; GO:0007628; GO:0007411; GO:0007155; GO:1904646; GO:0090102; GO:0021957; GO:0048013; GO:0097156; GO:0097155; GO:0008347; GO:0008045; GO:0048681; GO:0007162; GO:0030336; GO:1900038; GO:0010719; GO:0070373; GO:1900272; GO:0010977; GO:1903051; GO:0072178; GO:0007399; GO:0106030; GO:0097485; GO:0018108; GO:0016310; GO:1902004; GO:1902961; GO:0045785; GO:0030335; GO:0008284; GO:0050775; GO:0043507; GO:0033674; GO:0061098; GO:2001108; GO:0046777; GO:0006468; GO:0050821; GO:0048710; GO:0050770; GO:0061001; GO:0043087; GO:1905244; GO:1905806; GO:0098883; GO:0007169","PTHR46877:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3388|UniProtKB=P54764"]
["EphA4",null,"EPHA4","110","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2264",".CCP., .CP., .CSP., .HIF., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .SREME., .ST.",null,"EPHRIN TYPE-A RECEPTOR 4","adherens junction organization; adult walking behavior; axon guidance; cell adhesion; cellular response to amyloid-beta; cochlea development; corticospinal tract morphogenesis; ephrin receptor signaling pathway; fasciculation of motor neuron axon; fasciculation of sensory neuron axon; glial cell migration; motor neuron axon guidance; negative regulation of axon regeneration; negative regulation of cell adhesion; negative regulation of cell migration; negative regulation of cellular response to hypoxia; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of long-term synaptic potentiation; negative regulation of neuron projection development; negative regulation of proteolysis involved in protein catabolic process; nephric duct morphogenesis; nervous system development; neuron projection fasciculation; neuron projection guidance; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of amyloid-beta formation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of dendrite morphogenesis; positive regulation of JUN kinase activity; positive regulation of kinase activity; positive regulation of protein tyrosine kinase activity; positive regulation of Rho guanyl-nucleotide exchange factor activity; protein autophosphorylation; protein phosphorylation; protein stabilization; regulation of astrocyte differentiation; regulation of axonogenesis; regulation of dendritic spine morphogenesis; regulation of GTPase activity; regulation of modification of synaptic structure; regulation of synapse pruning; synapse pruning; transmembrane receptor protein tyrosine kinase signaling pathway","amyloid-beta binding; ATP binding; DH domain binding; ephrin receptor activity; ephrin receptor binding; GPI-linked ephrin receptor activity; identical protein binding; kinase activity; nucleotide binding; PH domain binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity","adherens junction; anchoring junction; axon; axon terminus; axonal growth cone; cell body; cell projection; cell surface; cytoplasm; dendrite; dendritic shaft; dendritic spine; early endosome; early endosome membrane; endoplasmic reticulum; endosome; filopodium; glutamatergic synapse; Golgi apparatus; membrane; mitochondrial outer membrane; neuromuscular junction; neuron projection; perikaryon; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; receptor complex; Schaffer collateral - CA1 synapse; synapse","Tyrosine kinase / adaptor","EPH receptor A4","http://www.ncbi.nlm.nih.gov/gene/?term=2043","2043","13838","316539",null,null,null,"P54764","Q03137","D3ZZK3","A0A8I3P796","A0A5G2QLV5","A0A1D5QL11","GO:0005912; GO:0070161; GO:0030424; GO:0043679; GO:0044295; GO:0044297; GO:0042995; GO:0009986; GO:0005737; GO:0030425; GO:0043198; GO:0043197; GO:0005769; GO:0031901; GO:0005783; GO:0005768; GO:0030175; GO:0098978; GO:0005794; GO:0016020; GO:0005741; GO:0031594; GO:0043005; GO:0043204; GO:0005886; GO:0014069; GO:0098839; GO:0045211; GO:0042734; GO:0043235; GO:0098685; GO:0045202","GO:0001540; GO:0005524; GO:0097161; GO:0005003; GO:0046875; GO:0005004; GO:0042802; GO:0016301; GO:0000166; GO:0042731; GO:0005515; GO:0004672; GO:0004713; GO:1990782; GO:0016740; GO:0004714; GO:0005005","GO:0034332; GO:0007628; GO:0007411; GO:0007155; GO:1904646; GO:0090102; GO:0021957; GO:0048013; GO:0097156; GO:0097155; GO:0008347; GO:0008045; GO:0048681; GO:0007162; GO:0030336; GO:1900038; GO:0010719; GO:0070373; GO:1900272; GO:0010977; GO:1903051; GO:0072178; GO:0007399; GO:0106030; GO:0097485; GO:0018108; GO:0016310; GO:1902004; GO:1902961; GO:0045785; GO:0030335; GO:0008284; GO:0050775; GO:0043507; GO:0033674; GO:0061098; GO:2001108; GO:0046777; GO:0006468; GO:0050821; GO:0048710; GO:0050770; GO:0061001; GO:0043087; GO:1905244; GO:1905806; GO:0098883; GO:0007169","PTHR46877:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3388|UniProtKB=P54764"]
["EphA4 - phospho","Tyr596","EPHA4","110","rb",null,6,4,"n/a","n/a","n/a","n/a","# 1339",".CCP., .CP., .CSP., .HIF., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .SREME., .ST.",null,"EPHRIN TYPE-A RECEPTOR 4","adherens junction organization; adult walking behavior; axon guidance; cell adhesion; cellular response to amyloid-beta; cochlea development; corticospinal tract morphogenesis; ephrin receptor signaling pathway; fasciculation of motor neuron axon; fasciculation of sensory neuron axon; glial cell migration; motor neuron axon guidance; negative regulation of axon regeneration; negative regulation of cell adhesion; negative regulation of cell migration; negative regulation of cellular response to hypoxia; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of long-term synaptic potentiation; negative regulation of neuron projection development; negative regulation of proteolysis involved in protein catabolic process; nephric duct morphogenesis; nervous system development; neuron projection fasciculation; neuron projection guidance; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of amyloid-beta formation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of dendrite morphogenesis; positive regulation of JUN kinase activity; positive regulation of kinase activity; positive regulation of protein tyrosine kinase activity; positive regulation of Rho guanyl-nucleotide exchange factor activity; protein autophosphorylation; protein phosphorylation; protein stabilization; regulation of astrocyte differentiation; regulation of axonogenesis; regulation of dendritic spine morphogenesis; regulation of GTPase activity; regulation of modification of synaptic structure; regulation of synapse pruning; synapse pruning; transmembrane receptor protein tyrosine kinase signaling pathway","amyloid-beta binding; ATP binding; DH domain binding; ephrin receptor activity; ephrin receptor binding; GPI-linked ephrin receptor activity; identical protein binding; kinase activity; nucleotide binding; PH domain binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity","adherens junction; anchoring junction; axon; axon terminus; axonal growth cone; cell body; cell projection; cell surface; cytoplasm; dendrite; dendritic shaft; dendritic spine; early endosome; early endosome membrane; endoplasmic reticulum; endosome; filopodium; glutamatergic synapse; Golgi apparatus; membrane; mitochondrial outer membrane; neuromuscular junction; neuron projection; perikaryon; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; receptor complex; Schaffer collateral - CA1 synapse; synapse","Tyrosine kinase / adaptor","EPH receptor A4","http://www.ncbi.nlm.nih.gov/gene/?term=2043","2043","13838","316539",null,null,null,"P54764","Q03137","D3ZZK3","A0A8I3P796","A0A5G2QLV5","A0A1D5QL11","GO:0005912; GO:0070161; GO:0030424; GO:0043679; GO:0044295; GO:0044297; GO:0042995; GO:0009986; GO:0005737; GO:0030425; GO:0043198; GO:0043197; GO:0005769; GO:0031901; GO:0005783; GO:0005768; GO:0030175; GO:0098978; GO:0005794; GO:0016020; GO:0005741; GO:0031594; GO:0043005; GO:0043204; GO:0005886; GO:0014069; GO:0098839; GO:0045211; GO:0042734; GO:0043235; GO:0098685; GO:0045202","GO:0001540; GO:0005524; GO:0097161; GO:0005003; GO:0046875; GO:0005004; GO:0042802; GO:0016301; GO:0000166; GO:0042731; GO:0005515; GO:0004672; GO:0004713; GO:1990782; GO:0016740; GO:0004714; GO:0005005","GO:0034332; GO:0007628; GO:0007411; GO:0007155; GO:1904646; GO:0090102; GO:0021957; GO:0048013; GO:0097156; GO:0097155; GO:0008347; GO:0008045; GO:0048681; GO:0007162; GO:0030336; GO:1900038; GO:0010719; GO:0070373; GO:1900272; GO:0010977; GO:1903051; GO:0072178; GO:0007399; GO:0106030; GO:0097485; GO:0018108; GO:0016310; GO:1902004; GO:1902961; GO:0045785; GO:0030335; GO:0008284; GO:0050775; GO:0043507; GO:0033674; GO:0061098; GO:2001108; GO:0046777; GO:0006468; GO:0050821; GO:0048710; GO:0050770; GO:0061001; GO:0043087; GO:1905244; GO:1905806; GO:0098883; GO:0007169","PTHR46877:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3388|UniProtKB=P54764"]
["EphB3",null,"EPHB3","110","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1335",".ANG., .CANCER., .CSP., .MIG., .OP., .OPA., .OT., .ST., .TD., .TMAT.","Angiogenesis","EPHRIN TYPE-B RECEPTOR 3","angiogenesis; axon guidance; axonal fasciculation; cell migration; central nervous system projection neuron axonogenesis; corpus callosum development; dendritic spine development; dendritic spine morphogenesis; digestive tract morphogenesis; ephrin receptor signaling pathway; nervous system development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of kinase activity; positive regulation of synapse assembly; protein autophosphorylation; protein phosphorylation; regulation of axonogenesis; regulation of cell-cell adhesion; regulation of GTPase activity; retinal ganglion cell axon guidance; roof of mouth development; substrate adhesion-dependent cell spreading; thymus development; transmembrane receptor protein tyrosine kinase signaling pathway; urogenital system development","ATP binding; axon guidance receptor activity; ephrin receptor activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity","cell projection; cytosol; dendrite; extracellular region; membrane; neuron projection; plasma membrane; receptor complex",null,"EPH receptor B3","http://www.ncbi.nlm.nih.gov/gene/?term=2049","2049","13845","287989",null,"100337659",null,"P54753","P54754","A0A8I5ZVE3","A0A8P0NF46","F1SG86","A0A5F7ZWD0","GO:0042995; GO:0005829; GO:0030425; GO:0005576; GO:0016020; GO:0043005; GO:0005886; GO:0043235","GO:0005524; GO:0008046; GO:0005003; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0005005","GO:0001525; GO:0007411; GO:0007413; GO:0016477; GO:0021952; GO:0022038; GO:0060996; GO:0060997; GO:0048546; GO:0048013; GO:0007399; GO:0018108; GO:0016310; GO:0033674; GO:0051965; GO:0046777; GO:0006468; GO:0050770; GO:0022407; GO:0043087; GO:0031290; GO:0060021; GO:0034446; GO:0048538; GO:0007169; GO:0001655","PTHR46877:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3394|UniProtKB=P54753","P00005"]
["EphB4",null,"EPHB4","108","rb",null,6,7,"n/a","n/a","n/a","n/a","# 1334",".ANG., .CANCER., .CSP., .OP., .OPA., .ST.","Angiogenesis","EPHRIN TYPE-B RECEPTOR 4","angiogenesis; axon guidance; cell adhesion; cell migration involved in sprouting angiogenesis; ephrin receptor signaling pathway; heart morphogenesis; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of kinase activity; protein autophosphorylation; protein phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; ephrin receptor activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity","cytosol; extracellular exosome; extracellular region; membrane; neuron projection; plasma membrane; receptor complex",null,"EPH receptor B4","http://www.ncbi.nlm.nih.gov/gene/?term=2050","2050","13846",null,"489830",null,null,"P54760","P54761","A0A8I6AIK2","A0A8I3MBN5","A0A287AYF2","A0A1D5QUS8","GO:0005829; GO:0070062; GO:0005576; GO:0016020; GO:0043005; GO:0005886; GO:0043235","GO:0005524; GO:0005003; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0005005","GO:0001525; GO:0007411; GO:0007155; GO:0002042; GO:0048013; GO:0003007; GO:0018108; GO:0016310; GO:0033674; GO:0046777; GO:0006468; GO:0007169","PTHR24416:SF296","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3395|UniProtKB=P54760","P00005"]
["EphB6",null,"EPHB6","109","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1344",".CSP., .OPA., .ST.",null,"EPHRIN TYPE-B RECEPTOR 6","axon guidance; central nervous system projection neuron axonogenesis; ephrin receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of kinase activity; protein phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; ephrin receptor activity; nucleotide binding; protein binding; protein kinase activity; signaling receptor activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity","cytosol; extracellular region; membrane; neuron projection; plasma membrane; receptor complex",null,"EPH receptor B6","http://www.ncbi.nlm.nih.gov/gene/?term=2051","2051",null,null,null,null,null,"O15197",null,null,null,null,null,"GO:0005829; GO:0005576; GO:0016020; GO:0043005; GO:0005886; GO:0043235","GO:0005524; GO:0005003; GO:0000166; GO:0005515; GO:0004672; GO:0038023; GO:0004714; GO:0005005","GO:0007411; GO:0021952; GO:0048013; GO:0018108; GO:0033674; GO:0006468; GO:0007169","PTHR46877:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3396|UniProtKB=O15197"]
["Ephrin B - phospho","Tyr324/Tyr329","EFNB3","59","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1304",".CSP., .IMUF., .IMUR., .OP., .OPA., .ST., .TCR., .VIR.",null,"EPHRIN-B3","adult walking behavior; axon choice point recognition; axon guidance; cell differentiation; cell-cell signaling; ephrin receptor signaling pathway; negative regulation of axonogenesis; nervous system development; positive regulation of presynapse assembly; positive regulation of synaptic transmission; T cell costimulation; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission; viral entry into host cell","ephrin receptor binding; protein binding; transmembrane-ephrin receptor activity; virus receptor activity","glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; membrane; plasma membrane; postsynaptic density membrane; presynaptic membrane",null,"ephrin B3","http://www.ncbi.nlm.nih.gov/gene/?term=1949","1949","13643","360546",null,"100135672",null,"Q15768","O35393","G3V7D4","A0A8I3PST8","B0LDT4","A0A1D5Q3L1","GO:0098978; GO:0098686; GO:0016020; GO:0005886; GO:0098839; GO:0042734","GO:0046875; GO:0005515; GO:0005005; GO:0001618","GO:0007628; GO:0016198; GO:0007411; GO:0030154; GO:0007267; GO:0048013; GO:0050771; GO:0007399; GO:1905608; GO:0050806; GO:0031295; GO:0099557; GO:0046718","PTHR11304:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3228|UniProtKB=Q15768"]
["ER alpha (estrogen receptor alpha)",null,"ESR1","67","rb",null,1,4,4,4,4,4,"# 1233",".APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .GPCR., .GPROT., .IMFR., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .ST., .TOLL., .TRASR.",null,"ESTROGEN RECEPTOR","androgen metabolic process; antral ovarian follicle growth; cellular response to estradiol stimulus; cellular response to estrogen stimulus; chromatin remodeling; epithelial cell development; epithelial cell proliferation involved in mammary gland duct elongation; fibroblast proliferation; intracellular estrogen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; male gonad development; mammary gland alveolus development; mammary gland branching involved in pregnancy; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of miRNA transcription; negative regulation of transcription by RNA polymerase II; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; positive regulation of phospholipase C activity; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; protein localization to chromatin; regulation of branching involved in prostate gland morphogenesis; regulation of DNA-templated transcription; regulation of epithelial cell apoptotic process; regulation of inflammatory response; regulation of toll-like receptor signaling pathway; regulation of transcription by RNA polymerase II; response to estradiol; response to estrogen; signal transduction; stem cell differentiation; steroid hormone mediated signaling pathway; transcription by RNA polymerase II; uterus development; vagina development","ATPase binding; beta-catenin binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; estrogen response element binding; identical protein binding; lipid binding; metal ion binding; nitric-oxide synthase regulator activity; nuclear estrogen receptor activity; nuclear estrogen receptor binding; nuclear receptor activity; nuclear steroid receptor activity; nucleic acid binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; steroid binding; TBP-class protein binding; TFIIB-class transcription factor binding; transcription coactivator binding; transcription coregulator binding; transcription corepressor binding; zinc ion binding","chromatin; cytoplasm; cytosol; euchromatin; Golgi apparatus; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; transcription preinitiation complex; transcription regulator complex","Nuclear receptor","estrogen receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=2099","2099","13982",null,null,"397435",null,"P03372","P19785","A0A0G2JZG2","A0A8I3M9P2","Q29040","A0A5F7ZJN3","GO:0000785; GO:0005737; GO:0005829; GO:0000791; GO:0005794; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0097550; GO:0005667","GO:0051117; GO:0008013; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0034056; GO:0042802; GO:0008289; GO:0046872; GO:0030235; GO:0030284; GO:0030331; GO:0004879; GO:0003707; GO:0003676; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0005496; GO:0017025; GO:0001093; GO:0001223; GO:0001221; GO:0001222; GO:0008270","GO:0008209; GO:0001547; GO:0071392; GO:0071391; GO:0006338; GO:0002064; GO:0060750; GO:0048144; GO:0030520; GO:0030518; GO:0008584; GO:0060749; GO:0060745; GO:0043433; GO:0010629; GO:0043124; GO:1902894; GO:0000122; GO:0007200; GO:0007204; GO:0051091; GO:0045893; GO:0048146; GO:0010863; GO:0045899; GO:0045944; GO:0060527; GO:0060523; GO:0071168; GO:0060687; GO:0006355; GO:1904035; GO:0050727; GO:0034121; GO:0006357; GO:0032355; GO:0043627; GO:0007165; GO:0048863; GO:0043401; GO:0006366; GO:0060065; GO:0060068","PTHR48092:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3467|UniProtKB=P03372"]
["ER alpha (estrogen receptor alpha)",null,"ESR1","66","rb",null,2,2.1,4,7,8,7,"# 1599",".APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .GPCR., .GPROT., .IMFR., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .ST., .TOLL., .TRASR.",null,"ESTROGEN RECEPTOR","androgen metabolic process; antral ovarian follicle growth; cellular response to estradiol stimulus; cellular response to estrogen stimulus; chromatin remodeling; epithelial cell development; epithelial cell proliferation involved in mammary gland duct elongation; fibroblast proliferation; intracellular estrogen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; male gonad development; mammary gland alveolus development; mammary gland branching involved in pregnancy; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of miRNA transcription; negative regulation of transcription by RNA polymerase II; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; positive regulation of phospholipase C activity; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; protein localization to chromatin; regulation of branching involved in prostate gland morphogenesis; regulation of DNA-templated transcription; regulation of epithelial cell apoptotic process; regulation of inflammatory response; regulation of toll-like receptor signaling pathway; regulation of transcription by RNA polymerase II; response to estradiol; response to estrogen; signal transduction; stem cell differentiation; steroid hormone mediated signaling pathway; transcription by RNA polymerase II; uterus development; vagina development","ATPase binding; beta-catenin binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; estrogen response element binding; identical protein binding; lipid binding; metal ion binding; nitric-oxide synthase regulator activity; nuclear estrogen receptor activity; nuclear estrogen receptor binding; nuclear receptor activity; nuclear steroid receptor activity; nucleic acid binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; steroid binding; TBP-class protein binding; TFIIB-class transcription factor binding; transcription coactivator binding; transcription coregulator binding; transcription corepressor binding; zinc ion binding","chromatin; cytoplasm; cytosol; euchromatin; Golgi apparatus; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; transcription preinitiation complex; transcription regulator complex","Nuclear receptor","estrogen receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=2099","2099","13982",null,null,"397435",null,"P03372","P19785","A0A0G2JZG2","A0A8I3M9P2","Q29040","A0A5F7ZJN3","GO:0000785; GO:0005737; GO:0005829; GO:0000791; GO:0005794; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0097550; GO:0005667","GO:0051117; GO:0008013; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0034056; GO:0042802; GO:0008289; GO:0046872; GO:0030235; GO:0030284; GO:0030331; GO:0004879; GO:0003707; GO:0003676; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0005496; GO:0017025; GO:0001093; GO:0001223; GO:0001221; GO:0001222; GO:0008270","GO:0008209; GO:0001547; GO:0071392; GO:0071391; GO:0006338; GO:0002064; GO:0060750; GO:0048144; GO:0030520; GO:0030518; GO:0008584; GO:0060749; GO:0060745; GO:0043433; GO:0010629; GO:0043124; GO:1902894; GO:0000122; GO:0007200; GO:0007204; GO:0051091; GO:0045893; GO:0048146; GO:0010863; GO:0045899; GO:0045944; GO:0060527; GO:0060523; GO:0071168; GO:0060687; GO:0006355; GO:1904035; GO:0050727; GO:0034121; GO:0006357; GO:0032355; GO:0043627; GO:0007165; GO:0048863; GO:0043401; GO:0006366; GO:0060065; GO:0060068","PTHR48092:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3467|UniProtKB=P03372"]
["ER alpha (estrogen receptor alpha) - phospho","Ser104/Ser106","ESR1","66","rb",null,4,4,"n/a","n/a","n/a","n/a","BG/MP # 050",".APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .GPCR., .GPROT., .IMFR., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .ST., .TOLL., .TRASR.",null,"ESTROGEN RECEPTOR","androgen metabolic process; antral ovarian follicle growth; cellular response to estradiol stimulus; cellular response to estrogen stimulus; chromatin remodeling; epithelial cell development; epithelial cell proliferation involved in mammary gland duct elongation; fibroblast proliferation; intracellular estrogen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; male gonad development; mammary gland alveolus development; mammary gland branching involved in pregnancy; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of miRNA transcription; negative regulation of transcription by RNA polymerase II; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; positive regulation of phospholipase C activity; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; protein localization to chromatin; regulation of branching involved in prostate gland morphogenesis; regulation of DNA-templated transcription; regulation of epithelial cell apoptotic process; regulation of inflammatory response; regulation of toll-like receptor signaling pathway; regulation of transcription by RNA polymerase II; response to estradiol; response to estrogen; signal transduction; stem cell differentiation; steroid hormone mediated signaling pathway; transcription by RNA polymerase II; uterus development; vagina development","ATPase binding; beta-catenin binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; estrogen response element binding; identical protein binding; lipid binding; metal ion binding; nitric-oxide synthase regulator activity; nuclear estrogen receptor activity; nuclear estrogen receptor binding; nuclear receptor activity; nuclear steroid receptor activity; nucleic acid binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; steroid binding; TBP-class protein binding; TFIIB-class transcription factor binding; transcription coactivator binding; transcription coregulator binding; transcription corepressor binding; zinc ion binding","chromatin; cytoplasm; cytosol; euchromatin; Golgi apparatus; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; transcription preinitiation complex; transcription regulator complex","Nuclear receptor","estrogen receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=2099","2099","13982",null,null,"397435",null,"P03372","P19785","A0A0G2JZG2","A0A8I3M9P2","Q29040","A0A5F7ZJN3","GO:0000785; GO:0005737; GO:0005829; GO:0000791; GO:0005794; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0097550; GO:0005667","GO:0051117; GO:0008013; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0034056; GO:0042802; GO:0008289; GO:0046872; GO:0030235; GO:0030284; GO:0030331; GO:0004879; GO:0003707; GO:0003676; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0005496; GO:0017025; GO:0001093; GO:0001223; GO:0001221; GO:0001222; GO:0008270","GO:0008209; GO:0001547; GO:0071392; GO:0071391; GO:0006338; GO:0002064; GO:0060750; GO:0048144; GO:0030520; GO:0030518; GO:0008584; GO:0060749; GO:0060745; GO:0043433; GO:0010629; GO:0043124; GO:1902894; GO:0000122; GO:0007200; GO:0007204; GO:0051091; GO:0045893; GO:0048146; GO:0010863; GO:0045899; GO:0045944; GO:0060527; GO:0060523; GO:0071168; GO:0060687; GO:0006355; GO:1904035; GO:0050727; GO:0034121; GO:0006357; GO:0032355; GO:0043627; GO:0007165; GO:0048863; GO:0043401; GO:0006366; GO:0060065; GO:0060068","PTHR48092:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3467|UniProtKB=P03372"]
["ER alpha (estrogen receptor alpha) - phospho","Ser118","ESR1","66","rb",null,7,4,"n/a","n/a","n/a","n/a","BG/MP # 052",".APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .GPCR., .GPROT., .IMFR., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .ST., .TOLL., .TRASR.",null,"ESTROGEN RECEPTOR","androgen metabolic process; antral ovarian follicle growth; cellular response to estradiol stimulus; cellular response to estrogen stimulus; chromatin remodeling; epithelial cell development; epithelial cell proliferation involved in mammary gland duct elongation; fibroblast proliferation; intracellular estrogen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; male gonad development; mammary gland alveolus development; mammary gland branching involved in pregnancy; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of miRNA transcription; negative regulation of transcription by RNA polymerase II; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; positive regulation of phospholipase C activity; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; protein localization to chromatin; regulation of branching involved in prostate gland morphogenesis; regulation of DNA-templated transcription; regulation of epithelial cell apoptotic process; regulation of inflammatory response; regulation of toll-like receptor signaling pathway; regulation of transcription by RNA polymerase II; response to estradiol; response to estrogen; signal transduction; stem cell differentiation; steroid hormone mediated signaling pathway; transcription by RNA polymerase II; uterus development; vagina development","ATPase binding; beta-catenin binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; estrogen response element binding; identical protein binding; lipid binding; metal ion binding; nitric-oxide synthase regulator activity; nuclear estrogen receptor activity; nuclear estrogen receptor binding; nuclear receptor activity; nuclear steroid receptor activity; nucleic acid binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; steroid binding; TBP-class protein binding; TFIIB-class transcription factor binding; transcription coactivator binding; transcription coregulator binding; transcription corepressor binding; zinc ion binding","chromatin; cytoplasm; cytosol; euchromatin; Golgi apparatus; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; transcription preinitiation complex; transcription regulator complex","Nuclear receptor","estrogen receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=2099","2099","13982",null,null,"397435",null,"P03372","P19785","A0A0G2JZG2","A0A8I3M9P2","Q29040","A0A5F7ZJN3","GO:0000785; GO:0005737; GO:0005829; GO:0000791; GO:0005794; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0097550; GO:0005667","GO:0051117; GO:0008013; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0034056; GO:0042802; GO:0008289; GO:0046872; GO:0030235; GO:0030284; GO:0030331; GO:0004879; GO:0003707; GO:0003676; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0005496; GO:0017025; GO:0001093; GO:0001223; GO:0001221; GO:0001222; GO:0008270","GO:0008209; GO:0001547; GO:0071392; GO:0071391; GO:0006338; GO:0002064; GO:0060750; GO:0048144; GO:0030520; GO:0030518; GO:0008584; GO:0060749; GO:0060745; GO:0043433; GO:0010629; GO:0043124; GO:1902894; GO:0000122; GO:0007200; GO:0007204; GO:0051091; GO:0045893; GO:0048146; GO:0010863; GO:0045899; GO:0045944; GO:0060527; GO:0060523; GO:0071168; GO:0060687; GO:0006355; GO:1904035; GO:0050727; GO:0034121; GO:0006357; GO:0032355; GO:0043627; GO:0007165; GO:0048863; GO:0043401; GO:0006366; GO:0060065; GO:0060068","PTHR48092:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3467|UniProtKB=P03372"]
["ER alpha (estrogen receptor alpha) - phospho","Ser167","ESR1","66","rb",null,4,4,"n/a","n/a","n/a","n/a","BG/MP # 053",".APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .GPCR., .GPROT., .IMFR., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .ST., .TOLL., .TRASR.",null,"ESTROGEN RECEPTOR","androgen metabolic process; antral ovarian follicle growth; cellular response to estradiol stimulus; cellular response to estrogen stimulus; chromatin remodeling; epithelial cell development; epithelial cell proliferation involved in mammary gland duct elongation; fibroblast proliferation; intracellular estrogen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; male gonad development; mammary gland alveolus development; mammary gland branching involved in pregnancy; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of miRNA transcription; negative regulation of transcription by RNA polymerase II; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; positive regulation of phospholipase C activity; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; protein localization to chromatin; regulation of branching involved in prostate gland morphogenesis; regulation of DNA-templated transcription; regulation of epithelial cell apoptotic process; regulation of inflammatory response; regulation of toll-like receptor signaling pathway; regulation of transcription by RNA polymerase II; response to estradiol; response to estrogen; signal transduction; stem cell differentiation; steroid hormone mediated signaling pathway; transcription by RNA polymerase II; uterus development; vagina development","ATPase binding; beta-catenin binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; estrogen response element binding; identical protein binding; lipid binding; metal ion binding; nitric-oxide synthase regulator activity; nuclear estrogen receptor activity; nuclear estrogen receptor binding; nuclear receptor activity; nuclear steroid receptor activity; nucleic acid binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; steroid binding; TBP-class protein binding; TFIIB-class transcription factor binding; transcription coactivator binding; transcription coregulator binding; transcription corepressor binding; zinc ion binding","chromatin; cytoplasm; cytosol; euchromatin; Golgi apparatus; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; transcription preinitiation complex; transcription regulator complex","Nuclear receptor","estrogen receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=2099","2099","13982",null,null,"397435",null,"P03372","P19785","A0A0G2JZG2","A0A8I3M9P2","Q29040","A0A5F7ZJN3","GO:0000785; GO:0005737; GO:0005829; GO:0000791; GO:0005794; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0097550; GO:0005667","GO:0051117; GO:0008013; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0034056; GO:0042802; GO:0008289; GO:0046872; GO:0030235; GO:0030284; GO:0030331; GO:0004879; GO:0003707; GO:0003676; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0005496; GO:0017025; GO:0001093; GO:0001223; GO:0001221; GO:0001222; GO:0008270","GO:0008209; GO:0001547; GO:0071392; GO:0071391; GO:0006338; GO:0002064; GO:0060750; GO:0048144; GO:0030520; GO:0030518; GO:0008584; GO:0060749; GO:0060745; GO:0043433; GO:0010629; GO:0043124; GO:1902894; GO:0000122; GO:0007200; GO:0007204; GO:0051091; GO:0045893; GO:0048146; GO:0010863; GO:0045899; GO:0045944; GO:0060527; GO:0060523; GO:0071168; GO:0060687; GO:0006355; GO:1904035; GO:0050727; GO:0034121; GO:0006357; GO:0032355; GO:0043627; GO:0007165; GO:0048863; GO:0043401; GO:0006366; GO:0060065; GO:0060068","PTHR48092:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3467|UniProtKB=P03372"]
["Erk1 (MAPK p44)",null,"MAPK3","44","rb",null,2,1,2,8,8,8,"# 3028",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BMP., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 3","animal organ morphogenesis; apoptotic process; Bergmann glial cell differentiation; BMP signaling pathway; cardiac neural crest cell development involved in heart development; cartilage development; caveolin-mediated endocytosis; cell cycle; cell surface receptor signaling pathway; cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to DNA damage stimulus; cellular response to dopamine; cellular response to mechanical stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; DNA-templated transcription; ERK1 and ERK2 cascade; face development; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-1-mediated signaling pathway; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; lung morphogenesis; MAPK cascade; modulation of chemical synaptic transmission; negative regulation of apolipoprotein binding; neural crest cell development; outer ear morphogenesis; peptidyl-tyrosine autophosphorylation; phosphorylation; positive regulation of cyclase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of xenophagy; protein phosphorylation; regulation of cellular pH; regulation of cytoskeleton organization; regulation of DNA-binding transcription factor activity; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of ossification; regulation of stress-activated MAPK cascade; response to chemical; response to epidermal growth factor; response to exogenous dsRNA; response to lipopolysaccharide; sensory perception of pain; signal transduction in response to DNA damage; stress-activated MAPK cascade; thymus development; thyroid gland development; trachea formation; xenophagy","ATP binding; DNA-binding transcription factor binding; identical protein binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; nucleotide binding; phosphatase binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","anchoring junction; caveola; cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum lumen; focal adhesion; glutamatergic synapse; Golgi apparatus; late endosome; membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus; plasma membrane; pseudopodium","MAPK signaling","mitogen-activated protein kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=5595","5595","26417",null,null,null,null,"P27361","Q63844","A0A8L2R3C3","A0A8P0NK57",null,"A0A1D5QZ91","GO:0070161; GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005788; GO:0005925; GO:0098978; GO:0005794; GO:0005770; GO:0016020; GO:0005739; GO:0005635; GO:0005654; GO:0005634; GO:0005886; GO:0031143","GO:0005524; GO:0140297; GO:0042802; GO:0016301; GO:0004707; GO:0004708; GO:0000166; GO:0019902; GO:0001784; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0009887; GO:0006915; GO:0060020; GO:0030509; GO:0061308; GO:0051216; GO:0072584; GO:0007049; GO:0007166; GO:0034198; GO:0071276; GO:0006974; GO:1903351; GO:0071260; GO:0034614; GO:0071356; GO:0006351; GO:0070371; GO:0060324; GO:0008286; GO:0048009; GO:0070498; GO:0035556; GO:0031663; GO:0060425; GO:0000165; GO:0050804; GO:2000657; GO:0014032; GO:0042473; GO:0038083; GO:0016310; GO:0031281; GO:0070374; GO:0010628; GO:0010759; GO:0120041; GO:0001934; GO:0051973; GO:1904355; GO:0032212; GO:0045944; GO:1904417; GO:0006468; GO:0030641; GO:0051493; GO:0051090; GO:2000641; GO:0090170; GO:0030278; GO:0032872; GO:0042221; GO:0070849; GO:0043330; GO:0032496; GO:0019233; GO:0042770; GO:0051403; GO:0048538; GO:0030878; GO:0060440; GO:0098792","PTHR24055:SF393","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6877|UniProtKB=P27361","P06959; P00053; P00032; P00052; P00010; P00056; P00036; P06664; P00021; P04393; P00035; P00034; P00047; P05911; P00005; P00054; P00049; P00018; P00003; P00031; P00019; P00006"]
["Erk1/2 (MAPK p44/42)",null,"MAPK3, MAPK1","44, 42","rb",null,1,1,1,1,1,1,"# 2680",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BMP., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 1","animal organ morphogenesis; apoptotic process; Bergmann glial cell differentiation; BMP signaling pathway; cardiac neural crest cell development involved in heart development; cartilage development; caveolin-mediated endocytosis; cell cycle; cell surface receptor signaling pathway; cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to DNA damage stimulus; cellular response to dopamine; cellular response to mechanical stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; DNA-templated transcription; ERK1 and ERK2 cascade; face development; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-1-mediated signaling pathway; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; lung morphogenesis; MAPK cascade; modulation of chemical synaptic transmission; negative regulation of apolipoprotein binding; neural crest cell development; outer ear morphogenesis; peptidyl-tyrosine autophosphorylation; phosphorylation; positive regulation of cyclase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of xenophagy; protein phosphorylation; regulation of cellular pH; regulation of cytoskeleton organization; regulation of DNA-binding transcription factor activity; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of ossification; regulation of stress-activated MAPK cascade; response to chemical; response to epidermal growth factor; response to exogenous dsRNA; response to lipopolysaccharide; sensory perception of pain; signal transduction in response to DNA damage; stress-activated MAPK cascade; thymus development; thyroid gland development; trachea formation; xenophagy; B cell receptor signaling pathway; chemical synaptic transmission; chemotaxis; cytosine metabolic process; ERBB signaling pathway; heart development; labyrinthine layer blood vessel development; learning or memory; long-term synaptic potentiation; mammary gland epithelial cell proliferation; negative regulation of cell differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; regulation of protein stability; response to nicotine; signal transduction; T cell receptor signaling pathway","ATP binding; DNA-binding transcription factor binding; identical protein binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; nucleotide binding; phosphatase binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; DNA binding; RNA polymerase II CTD heptapeptide repeat kinase activity","anchoring junction; caveola; cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum lumen; focal adhesion; glutamatergic synapse; Golgi apparatus; late endosome; membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus; plasma membrane; pseudopodium; azurophil granule lumen; extracellular region; ficolin-1-rich granule lumen; microtubule organizing center; mitotic spindle; spindle; synapse","MAPK signaling","mitogen-activated protein kinase 3; mitogen-activated protein kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5595, http://www.ncbi.nlm.nih.gov/gene/?term=5594","5595, 5594","26417, 26413","NA, 116590","NA, 477575","","NA, 698569","P27361, P28482","Q63844, P63085","A0A8L2R3C3, P63086","A0A8P0NK57, A0A8I3PZP0","A0A286ZPF5","A0A1D5QZ91, F7ECR3","GO:0070161; GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005788; GO:0005925; GO:0098978; GO:0005794; GO:0005770; GO:0016020; GO:0005739; GO:0005635; GO:0005654; GO:0005634; GO:0005886; GO:0031143; GO:0035578; GO:0005576; GO:1904813; GO:0005815; GO:0072686; GO:0005819; GO:0045202","GO:0005524; GO:0140297; GO:0042802; GO:0016301; GO:0004707; GO:0004708; GO:0000166; GO:0019902; GO:0001784; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740; GO:0003677; GO:0008353","GO:0009887; GO:0006915; GO:0060020; GO:0030509; GO:0061308; GO:0051216; GO:0072584; GO:0007049; GO:0007166; GO:0034198; GO:0071276; GO:0006974; GO:1903351; GO:0071260; GO:0034614; GO:0071356; GO:0006351; GO:0070371; GO:0060324; GO:0008286; GO:0048009; GO:0070498; GO:0035556; GO:0031663; GO:0060425; GO:0000165; GO:0050804; GO:2000657; GO:0014032; GO:0042473; GO:0038083; GO:0016310; GO:0031281; GO:0070374; GO:0010628; GO:0010759; GO:0120041; GO:0001934; GO:0051973; GO:1904355; GO:0032212; GO:0045944; GO:1904417; GO:0006468; GO:0030641; GO:0051493; GO:0051090; GO:2000641; GO:0090170; GO:0030278; GO:0032872; GO:0042221; GO:0070849; GO:0043330; GO:0032496; GO:0019233; GO:0042770; GO:0051403; GO:0048538; GO:0030878; GO:0060440; GO:0098792; GO:0050853; GO:0007268; GO:0006935; GO:0019858; GO:0038127; GO:0007507; GO:0060716; GO:0007611; GO:0060291; GO:0033598; GO:0045596; GO:0018105; GO:0018107; GO:0010800; GO:0031647; GO:0035094; GO:0007165; GO:0050852","PTHR24055:SF393; PTHR24055:SF569","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6877|UniProtKB=P27361; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6871|UniProtKB=P28482","P06959; P00053; P00032; P00052; P00010; P00056; P00036; P06664; P00021; P04393; P00035; P00034; P00047; P05911; P00005; P00054; P00049; P00018; P00003; P00031; P00019; P00006"]
["Erk1/2 (MAPK p44/42) - phospho","Thr202/Tyr204","MAPK3, MAPK1","44, 42","rb",null,1,1,1,8.1,7,8,"# 2059",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BMP., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 1","animal organ morphogenesis; apoptotic process; Bergmann glial cell differentiation; BMP signaling pathway; cardiac neural crest cell development involved in heart development; cartilage development; caveolin-mediated endocytosis; cell cycle; cell surface receptor signaling pathway; cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to DNA damage stimulus; cellular response to dopamine; cellular response to mechanical stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; DNA-templated transcription; ERK1 and ERK2 cascade; face development; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-1-mediated signaling pathway; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; lung morphogenesis; MAPK cascade; modulation of chemical synaptic transmission; negative regulation of apolipoprotein binding; neural crest cell development; outer ear morphogenesis; peptidyl-tyrosine autophosphorylation; phosphorylation; positive regulation of cyclase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of xenophagy; protein phosphorylation; regulation of cellular pH; regulation of cytoskeleton organization; regulation of DNA-binding transcription factor activity; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of ossification; regulation of stress-activated MAPK cascade; response to chemical; response to epidermal growth factor; response to exogenous dsRNA; response to lipopolysaccharide; sensory perception of pain; signal transduction in response to DNA damage; stress-activated MAPK cascade; thymus development; thyroid gland development; trachea formation; xenophagy; B cell receptor signaling pathway; chemical synaptic transmission; chemotaxis; cytosine metabolic process; ERBB signaling pathway; heart development; labyrinthine layer blood vessel development; learning or memory; long-term synaptic potentiation; mammary gland epithelial cell proliferation; negative regulation of cell differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; regulation of protein stability; response to nicotine; signal transduction; T cell receptor signaling pathway","ATP binding; DNA-binding transcription factor binding; identical protein binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; nucleotide binding; phosphatase binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; DNA binding; RNA polymerase II CTD heptapeptide repeat kinase activity","anchoring junction; caveola; cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum lumen; focal adhesion; glutamatergic synapse; Golgi apparatus; late endosome; membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus; plasma membrane; pseudopodium; azurophil granule lumen; extracellular region; ficolin-1-rich granule lumen; microtubule organizing center; mitotic spindle; spindle; synapse","MAPK signaling","mitogen-activated protein kinase 3; mitogen-activated protein kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5595, http://www.ncbi.nlm.nih.gov/gene/?term=5594","5595, 5594","26417, 26413","NA, 116590","NA, 477575","","NA, 698569","P27361, P28482","Q63844, P63085","A0A8L2R3C3, P63086","A0A8P0NK57, A0A8I3PZP0","A0A286ZPF5","A0A1D5QZ91, F7ECR3","GO:0070161; GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005788; GO:0005925; GO:0098978; GO:0005794; GO:0005770; GO:0016020; GO:0005739; GO:0005635; GO:0005654; GO:0005634; GO:0005886; GO:0031143; GO:0035578; GO:0005576; GO:1904813; GO:0005815; GO:0072686; GO:0005819; GO:0045202","GO:0005524; GO:0140297; GO:0042802; GO:0016301; GO:0004707; GO:0004708; GO:0000166; GO:0019902; GO:0001784; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740; GO:0003677; GO:0008353","GO:0009887; GO:0006915; GO:0060020; GO:0030509; GO:0061308; GO:0051216; GO:0072584; GO:0007049; GO:0007166; GO:0034198; GO:0071276; GO:0006974; GO:1903351; GO:0071260; GO:0034614; GO:0071356; GO:0006351; GO:0070371; GO:0060324; GO:0008286; GO:0048009; GO:0070498; GO:0035556; GO:0031663; GO:0060425; GO:0000165; GO:0050804; GO:2000657; GO:0014032; GO:0042473; GO:0038083; GO:0016310; GO:0031281; GO:0070374; GO:0010628; GO:0010759; GO:0120041; GO:0001934; GO:0051973; GO:1904355; GO:0032212; GO:0045944; GO:1904417; GO:0006468; GO:0030641; GO:0051493; GO:0051090; GO:2000641; GO:0090170; GO:0030278; GO:0032872; GO:0042221; GO:0070849; GO:0043330; GO:0032496; GO:0019233; GO:0042770; GO:0051403; GO:0048538; GO:0030878; GO:0060440; GO:0098792; GO:0050853; GO:0007268; GO:0006935; GO:0019858; GO:0038127; GO:0007507; GO:0060716; GO:0007611; GO:0060291; GO:0033598; GO:0045596; GO:0018105; GO:0018107; GO:0010800; GO:0031647; GO:0035094; GO:0007165; GO:0050852","PTHR24055:SF393; PTHR24055:SF569","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6877|UniProtKB=P27361; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6871|UniProtKB=P28482","P06959; P00053; P00032; P00052; P00010; P00056; P00036; P06664; P00021; P04393; P00035; P00034; P00047; P05911; P00005; P00054; P00049; P00018; P00003; P00031; P00019; P00006"]
["Erk1/2 (MAPK p44/42) - phospho","Tyr204","MAPK3, MAPK1","44, 42","ms",null,1,1,8,8,8,8,"# 0901",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BMP., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DRR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 1","animal organ morphogenesis; apoptotic process; Bergmann glial cell differentiation; BMP signaling pathway; cardiac neural crest cell development involved in heart development; cartilage development; caveolin-mediated endocytosis; cell cycle; cell surface receptor signaling pathway; cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to DNA damage stimulus; cellular response to dopamine; cellular response to mechanical stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; DNA-templated transcription; ERK1 and ERK2 cascade; face development; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-1-mediated signaling pathway; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; lung morphogenesis; MAPK cascade; modulation of chemical synaptic transmission; negative regulation of apolipoprotein binding; neural crest cell development; outer ear morphogenesis; peptidyl-tyrosine autophosphorylation; phosphorylation; positive regulation of cyclase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of xenophagy; protein phosphorylation; regulation of cellular pH; regulation of cytoskeleton organization; regulation of DNA-binding transcription factor activity; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of ossification; regulation of stress-activated MAPK cascade; response to chemical; response to epidermal growth factor; response to exogenous dsRNA; response to lipopolysaccharide; sensory perception of pain; signal transduction in response to DNA damage; stress-activated MAPK cascade; thymus development; thyroid gland development; trachea formation; xenophagy; B cell receptor signaling pathway; chemical synaptic transmission; chemotaxis; cytosine metabolic process; ERBB signaling pathway; heart development; labyrinthine layer blood vessel development; learning or memory; long-term synaptic potentiation; mammary gland epithelial cell proliferation; negative regulation of cell differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; regulation of protein stability; response to nicotine; signal transduction; T cell receptor signaling pathway","ATP binding; DNA-binding transcription factor binding; identical protein binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; nucleotide binding; phosphatase binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; DNA binding; RNA polymerase II CTD heptapeptide repeat kinase activity","anchoring junction; caveola; cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum lumen; focal adhesion; glutamatergic synapse; Golgi apparatus; late endosome; membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus; plasma membrane; pseudopodium; azurophil granule lumen; extracellular region; ficolin-1-rich granule lumen; microtubule organizing center; mitotic spindle; spindle; synapse","MAPK signaling","mitogen-activated protein kinase 3; mitogen-activated protein kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5595, http://www.ncbi.nlm.nih.gov/gene/?term=5594","5595, 5594","26417, 26413","NA, 116590","NA, 477575","","NA, 698569","P27361, P28482","Q63844, P63085","A0A8L2R3C3, P63086","A0A8P0NK57, A0A8I3PZP0","A0A286ZPF5","A0A1D5QZ91, F7ECR3","GO:0070161; GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005788; GO:0005925; GO:0098978; GO:0005794; GO:0005770; GO:0016020; GO:0005739; GO:0005635; GO:0005654; GO:0005634; GO:0005886; GO:0031143; GO:0035578; GO:0005576; GO:1904813; GO:0005815; GO:0072686; GO:0005819; GO:0045202","GO:0005524; GO:0140297; GO:0042802; GO:0016301; GO:0004707; GO:0004708; GO:0000166; GO:0019902; GO:0001784; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740; GO:0003677; GO:0008353","GO:0009887; GO:0006915; GO:0060020; GO:0030509; GO:0061308; GO:0051216; GO:0072584; GO:0007049; GO:0007166; GO:0034198; GO:0071276; GO:0006974; GO:1903351; GO:0071260; GO:0034614; GO:0071356; GO:0006351; GO:0070371; GO:0060324; GO:0008286; GO:0048009; GO:0070498; GO:0035556; GO:0031663; GO:0060425; GO:0000165; GO:0050804; GO:2000657; GO:0014032; GO:0042473; GO:0038083; GO:0016310; GO:0031281; GO:0070374; GO:0010628; GO:0010759; GO:0120041; GO:0001934; GO:0051973; GO:1904355; GO:0032212; GO:0045944; GO:1904417; GO:0006468; GO:0030641; GO:0051493; GO:0051090; GO:2000641; GO:0090170; GO:0030278; GO:0032872; GO:0042221; GO:0070849; GO:0043330; GO:0032496; GO:0019233; GO:0042770; GO:0051403; GO:0048538; GO:0030878; GO:0060440; GO:0098792; GO:0050853; GO:0007268; GO:0006935; GO:0019858; GO:0038127; GO:0007507; GO:0060716; GO:0007611; GO:0060291; GO:0033598; GO:0045596; GO:0018105; GO:0018107; GO:0010800; GO:0031647; GO:0035094; GO:0007165; GO:0050852","PTHR24055:SF393; PTHR24055:SF569","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6877|UniProtKB=P27361; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6871|UniProtKB=P28482","P06959; P00053; P00032; P00052; P00010; P00056; P00036; P06664; P00021; P04393; P00035; P00034; P00047; P05911; P00005; P00054; P00049; P00018; P00003; P00031; P00019; P00006"]
["ERK1/2 (MAPK) - phospho","Thr202/Tyr204","MAPK3, MAPK1","44, 42","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2681",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BMP., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 1","animal organ morphogenesis; apoptotic process; Bergmann glial cell differentiation; BMP signaling pathway; cardiac neural crest cell development involved in heart development; cartilage development; caveolin-mediated endocytosis; cell cycle; cell surface receptor signaling pathway; cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to DNA damage stimulus; cellular response to dopamine; cellular response to mechanical stimulus; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; DNA-templated transcription; ERK1 and ERK2 cascade; face development; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; interleukin-1-mediated signaling pathway; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; lung morphogenesis; MAPK cascade; modulation of chemical synaptic transmission; negative regulation of apolipoprotein binding; neural crest cell development; outer ear morphogenesis; peptidyl-tyrosine autophosphorylation; phosphorylation; positive regulation of cyclase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of xenophagy; protein phosphorylation; regulation of cellular pH; regulation of cytoskeleton organization; regulation of DNA-binding transcription factor activity; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of ossification; regulation of stress-activated MAPK cascade; response to chemical; response to epidermal growth factor; response to exogenous dsRNA; response to lipopolysaccharide; sensory perception of pain; signal transduction in response to DNA damage; stress-activated MAPK cascade; thymus development; thyroid gland development; trachea formation; xenophagy; B cell receptor signaling pathway; chemical synaptic transmission; chemotaxis; cytosine metabolic process; ERBB signaling pathway; heart development; labyrinthine layer blood vessel development; learning or memory; long-term synaptic potentiation; mammary gland epithelial cell proliferation; negative regulation of cell differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; regulation of protein stability; response to nicotine; signal transduction; T cell receptor signaling pathway","ATP binding; DNA-binding transcription factor binding; identical protein binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; nucleotide binding; phosphatase binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; DNA binding; RNA polymerase II CTD heptapeptide repeat kinase activity","anchoring junction; caveola; cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum lumen; focal adhesion; glutamatergic synapse; Golgi apparatus; late endosome; membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus; plasma membrane; pseudopodium; azurophil granule lumen; extracellular region; ficolin-1-rich granule lumen; microtubule organizing center; mitotic spindle; spindle; synapse","MAPK signaling","mitogen-activated protein kinase 3; mitogen-activated protein kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5595, http://www.ncbi.nlm.nih.gov/gene/?term=5594","5595, 5594","26417, 26413","NA, 116590","NA, 477575","","NA, 698569","P27361, P28482","Q63844, P63085","A0A8L2R3C3, P63086","A0A8P0NK57, A0A8I3PZP0","A0A286ZPF5","A0A1D5QZ91, F7ECR3","GO:0070161; GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005788; GO:0005925; GO:0098978; GO:0005794; GO:0005770; GO:0016020; GO:0005739; GO:0005635; GO:0005654; GO:0005634; GO:0005886; GO:0031143; GO:0035578; GO:0005576; GO:1904813; GO:0005815; GO:0072686; GO:0005819; GO:0045202","GO:0005524; GO:0140297; GO:0042802; GO:0016301; GO:0004707; GO:0004708; GO:0000166; GO:0019902; GO:0001784; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740; GO:0003677; GO:0008353","GO:0009887; GO:0006915; GO:0060020; GO:0030509; GO:0061308; GO:0051216; GO:0072584; GO:0007049; GO:0007166; GO:0034198; GO:0071276; GO:0006974; GO:1903351; GO:0071260; GO:0034614; GO:0071356; GO:0006351; GO:0070371; GO:0060324; GO:0008286; GO:0048009; GO:0070498; GO:0035556; GO:0031663; GO:0060425; GO:0000165; GO:0050804; GO:2000657; GO:0014032; GO:0042473; GO:0038083; GO:0016310; GO:0031281; GO:0070374; GO:0010628; GO:0010759; GO:0120041; GO:0001934; GO:0051973; GO:1904355; GO:0032212; GO:0045944; GO:1904417; GO:0006468; GO:0030641; GO:0051493; GO:0051090; GO:2000641; GO:0090170; GO:0030278; GO:0032872; GO:0042221; GO:0070849; GO:0043330; GO:0032496; GO:0019233; GO:0042770; GO:0051403; GO:0048538; GO:0030878; GO:0060440; GO:0098792; GO:0050853; GO:0007268; GO:0006935; GO:0019858; GO:0038127; GO:0007507; GO:0060716; GO:0007611; GO:0060291; GO:0033598; GO:0045596; GO:0018105; GO:0018107; GO:0010800; GO:0031647; GO:0035094; GO:0007165; GO:0050852","PTHR24055:SF393; PTHR24055:SF569","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6877|UniProtKB=P27361; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6871|UniProtKB=P28482","P06959; P00053; P00032; P00052; P00010; P00056; P00036; P06664; P00021; P04393; P00035; P00034; P00047; P05911; P00005; P00054; P00049; P00018; P00003; P00031; P00019; P00006"]
["Erk2 (MAPK p42)",null,"MAPK1","42","rb",null,2,2,2,1,2,2,"TK # 010",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DRR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 1","animal organ morphogenesis; apoptotic process; B cell receptor signaling pathway; Bergmann glial cell differentiation; cardiac neural crest cell development involved in heart development; caveolin-mediated endocytosis; cell cycle; cell surface receptor signaling pathway; cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to DNA damage stimulus; cellular response to dopamine; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; chemical synaptic transmission; chemotaxis; cytosine metabolic process; ERBB signaling pathway; ERK1 and ERK2 cascade; face development; heart development; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; learning or memory; lipopolysaccharide-mediated signaling pathway; long-term synaptic potentiation; lung morphogenesis; mammary gland epithelial cell proliferation; MAPK cascade; negative regulation of cell differentiation; neural crest cell development; outer ear morphogenesis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of gene expression; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein phosphorylation; regulation of cellular pH; regulation of cytoskeleton organization; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of ossification; regulation of protein stability; regulation of stress-activated MAPK cascade; response to chemical; response to epidermal growth factor; response to exogenous dsRNA; response to lipopolysaccharide; response to nicotine; signal transduction; stress-activated MAPK cascade; T cell receptor signaling pathway; thymus development; thyroid gland development; trachea formation","ATP binding; DNA binding; identical protein binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; nucleotide binding; phosphatase binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity","anchoring junction; azurophil granule lumen; caveola; cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum lumen; extracellular region; ficolin-1-rich granule lumen; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule organizing center; mitochondrion; mitotic spindle; nucleoplasm; nucleus; plasma membrane; pseudopodium; spindle; synapse","MAPK signaling","mitogen-activated protein kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5594","5594","26413","116590","477575",null,"698569","P28482","P63085","P63086","A0A8I3PZP0","A0A286ZPF5","F7ECR3","GO:0070161; GO:0035578; GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005788; GO:0005576; GO:1904813; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005815; GO:0005739; GO:0072686; GO:0005654; GO:0005634; GO:0005886; GO:0031143; GO:0005819; GO:0045202","GO:0005524; GO:0003677; GO:0042802; GO:0016301; GO:0004707; GO:0004708; GO:0000166; GO:0019902; GO:0001784; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0008353; GO:0016740","GO:0009887; GO:0006915; GO:0050853; GO:0060020; GO:0061308; GO:0072584; GO:0007049; GO:0007166; GO:0034198; GO:0071276; GO:0006974; GO:1903351; GO:0034614; GO:0071356; GO:0007268; GO:0006935; GO:0019858; GO:0038127; GO:0070371; GO:0060324; GO:0007507; GO:0008286; GO:0048009; GO:0035556; GO:0060716; GO:0007611; GO:0031663; GO:0060291; GO:0060425; GO:0033598; GO:0000165; GO:0045596; GO:0014032; GO:0042473; GO:0018105; GO:0018107; GO:0016310; GO:0010628; GO:0010759; GO:0120041; GO:0010800; GO:0051973; GO:1904355; GO:0032212; GO:0006468; GO:0030641; GO:0051493; GO:2000641; GO:0090170; GO:0030278; GO:0031647; GO:0032872; GO:0042221; GO:0070849; GO:0043330; GO:0032496; GO:0035094; GO:0007165; GO:0051403; GO:0050852; GO:0048538; GO:0030878; GO:0060440","PTHR24055:SF569","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6871|UniProtKB=P28482","P06959; P00053; P00032; P00052; P00010; P00056; P00036; P06664; P00021; P04393; P00035; P00034; P00047; P05911; P00005; P00054; P00049; P00018; P00003; P00031; P00019; P00006"]
["Erk3 (MAPK 6)",null,"MAPK6","105","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0248",".ALZ., .ANG., .CANCER., .CCP., .CCY., .CSP., .DI., .INT., .MAPK., .OP., .OPA., .PDGF., .RTK., .ST., .VEGFS.","VEGF signaling pathway; Interleukin signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Alzheimer disease-amyloid secretase pathway","MITOGEN-ACTIVATED PROTEIN KINASE 6","cell cycle; intracellular signal transduction; MAPK cascade; phosphorylation; positive regulation of dendritic spine development; protein phosphorylation; signal transduction","ATP binding; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex; septin cytoskeleton","MAPK signaling","mitogen-activated protein kinase 6","http://www.ncbi.nlm.nih.gov/gene/?term=5597","5597","50772","58840","478311","396833","694998","Q16659","Q61532","P27704","A0A8P0SQ67","F1RZB8","F7GB31","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0032991; GO:0032156","GO:0005524; GO:0016301; GO:0004707; GO:0000166; GO:0005515; GO:0046982; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0035556; GO:0000165; GO:0016310; GO:0060999; GO:0006468; GO:0007165","PTHR24055:SF171","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6879|UniProtKB=Q16659","P00056; P00036; P00034; P00047; P00005; P00003"]
["Ero1-L alpha",null,"ERO1A","60","rb",null,2.1,4,4,4,4,4,"# 0688",".APO., .CD., .CSP., .HIF., .OPA., .SREME., .ST.",null,"ERO1-LIKE PROTEIN ALPHA","apoptotic process; brown fat cell differentiation; cell redox homeostasis; cellular response to hypoxia; chaperone cofactor-dependent protein refolding; endoplasmic reticulum unfolded protein response; extracellular matrix organization; insulin processing; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; protein folding; protein folding in endoplasmic reticulum; protein maturation by protein folding; protein modification process; release of sequestered calcium ion into cytosol; response to endoplasmic reticulum stress; response to oxidative stress; response to temperature stimulus","disulfide oxidoreductase activity; FAD binding; oxidoreductase activity; protein binding; protein-disulfide reductase activity; thiol oxidase activity","cell projection; dendrite; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular region; extracellular space; Golgi apparatus; Golgi lumen; intracellular membrane-bounded organelle; membrane","MAPK signaling","endoplasmic reticulum oxidoreductase 1 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=30001","30001","50527","171562",null,null,null,"Q96HE7","Q8R180","Q8R4A1","A0A8I3MJK4","A0A287BEL0","A0A1D5QIC4","GO:0042995; GO:0030425; GO:0005783; GO:0005788; GO:0005789; GO:0005576; GO:0005615; GO:0005794; GO:0005796; GO:0043231; GO:0016020","GO:0015036; GO:0071949; GO:0016491; GO:0005515; GO:0015035; GO:0016972","GO:0006915; GO:0050873; GO:0045454; GO:0071456; GO:0051085; GO:0030968; GO:0030198; GO:0030070; GO:0070059; GO:0018401; GO:0006457; GO:0034975; GO:0022417; GO:0036211; GO:0051209; GO:0034976; GO:0006979; GO:0009266","PTHR12613:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13280|UniProtKB=Q96HE7"]
["ESRRB",null,"ESRRB","48","rb",null,1,1,"n/a","n/a","n/a","n/a","# 1707",".CCP., .CCY., .CP., .CSP., .OP., .OPA., .OT., .ST., .TRASR.",null,"STEROID HORMONE RECEPTOR ERR2","cell dedifferentiation; embryonic placenta development; inner ear development; intracellular receptor signaling pathway; negative regulation of stem cell differentiation; photoreceptor cell maintenance; positive regulation of DNA-templated transcription; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; positive regulation of transcription involved in G1/S transition of mitotic cell cycle; positive regulation of transcription involved in G2/M transition of mitotic cell cycle; regulation of DNA-templated transcription; regulation of stem cell division; regulation of transcription by RNA polymerase II; stem cell division; stem cell population maintenance; steroid hormone mediated signaling pathway","cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; nuclear receptor activity; nuclear steroid receptor activity; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II complex binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; steroid binding; zinc ion binding","chromatin; chromosome; condensed chromosome; cytoplasm; cytosol; integrator complex; nucleoplasm; nucleus",null,"estrogen related receptor beta","http://www.ncbi.nlm.nih.gov/gene/?term=2103","2103","26380",null,null,"100151940","703799","O95718","Q61539","A0A8I6A8M0","A0A8I3MPU9","A0A287AYZ8","F7DBF0","GO:0000785; GO:0005694; GO:0000793; GO:0005737; GO:0005829; GO:0032039; GO:0005654; GO:0005634","GO:0000987; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0046872; GO:0004879; GO:0003707; GO:0003676; GO:0000978; GO:0000993; GO:0061629; GO:0043565; GO:1990837; GO:0005496; GO:0008270","GO:0043697; GO:0001892; GO:0048839; GO:0030522; GO:2000737; GO:0045494; GO:0045893; GO:1902459; GO:0045944; GO:0071931; GO:0090282; GO:0006355; GO:2000035; GO:0006357; GO:0017145; GO:0019827; GO:0043401","PTHR48092:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3473|UniProtKB=O95718"]
["Evi-1",null,"MECOM","200, 145, 105","rb",null,2,4,4,4,4,4,"# 1482",".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .JNK., .MAPK., .OP., .OT., .RTK., .SREME., .TRASR.",null,"HISTONE-LYSINE N-METHYLTRANSFERASE MECOM","apoptotic process; cell differentiation; hematopoietic stem cell proliferation; heterochromatin organization; histone modification; methylation; negative regulation of DNA-templated transcription; negative regulation of JNK cascade; negative regulation of programmed cell death; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of transcription by RNA polymerase II","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; histone H3K9 methyltransferase activity; histone H3K9 monomethyltransferase activity; histone H3K9me2 methyltransferase activity; histone lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transferase activity","cytoplasm; cytosol; histone deacetylase complex; nuclear speck; nucleoplasm; nucleus","Lymphocyte signaling","MDS1 and EVI1 complex locus","http://www.ncbi.nlm.nih.gov/gene/?term=2122","2122","14013",null,null,null,null,"Q03112","P14404","A0A8I6AF72","A0A8I3P8H3","A0A287AR92","A0A1D5R6D6","GO:0005737; GO:0005829; GO:0000118; GO:0016607; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0003700; GO:0046974; GO:0140948; GO:0140947; GO:0018024; GO:0046872; GO:0008168; GO:0005515; GO:0000978; GO:0016740","GO:0006915; GO:0030154; GO:0071425; GO:0070828; GO:0016570; GO:0032259; GO:0045892; GO:0046329; GO:0043069; GO:0045893; GO:0045944; GO:0051726; GO:0006357","PTHR24393:SF69","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3498|UniProtKB=Q03112"]
["EXTL2",null,"EXTL2","37","rb",null,2,2,2,2,2,7,"# 0963",null,null,"EXOSTOSIN-LIKE 2","heparan sulfate proteoglycan biosynthetic process; N-acetylglucosamine metabolic process; UDP-N-acetylgalactosamine metabolic process","alpha-1,4-N-acetylgalactosaminyltransferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; glycosaminoglycan binding; glycosyltransferase activity; manganese ion binding; metal ion binding; protein binding; transferase activity","cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular region; membrane; nucleoplasm",null,"exostosin like glycosyltransferase 2","http://www.ncbi.nlm.nih.gov/gene/?term=2135","2135","58193",null,"479925",null,null,"Q9UBQ6","Q9ES89","F7F8T0","A0A8I3NG09","A0A286ZNT6","A0A1D5QAP5","GO:0005829; GO:0005783; GO:0005789; GO:0005576; GO:0016020; GO:0005654","GO:0035248; GO:0001888; GO:0047237; GO:0005539; GO:0016757; GO:0030145; GO:0046872; GO:0005515; GO:0016740","GO:0015012; GO:0006044; GO:0019276","PTHR47844:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3516|UniProtKB=Q9UBQ6"]
["Ezh2",null,"EZH2","98","rb",null,1,1,8,8,8,8,"# 1759",".BCR., .CCP., .CCY., .CP., .CSP., .IMUF., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR.",null,"HISTONE-LYSINE N-METHYLTRANSFERASE EZH2","B cell differentiation; cardiac muscle hypertrophy in response to stress; cellular response to hydrogen peroxide; cellular response to trichostatin A; cerebellar cortex development; chromatin organization; chromatin remodeling; DNA methylation; epidermal cell differentiation; facultative heterochromatin formation; G1 to G0 transition; G1/S transition of mitotic cell cycle; hemopoiesis; hepatocyte homeostasis; heterochromatin formation; hippocampus development; histone H3-K27 methylation; histone H3-K27 trimethylation; histone modification; keratinocyte differentiation; liver regeneration; methylation; negative regulation of cytokine production involved in inflammatory response; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of epidermal cell differentiation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of gene expression, epigenetic; negative regulation of keratinocyte differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of stem cell differentiation; negative regulation of striated muscle cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription elongation by RNA polymerase II; positive regulation of cell cycle G1/S phase transition; positive regulation of cell population proliferation; positive regulation of dendrite development; positive regulation of epithelial to mesenchymal transition; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of protein serine/threonine kinase activity; protein localization to chromatin; regulation of cell population proliferation; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of gene expression; regulation of gliogenesis; regulation of neurogenesis; regulation of protein phosphorylation; regulation of transcription by RNA polymerase II; response to estradiol; response to tetrachloromethane; rhythmic process; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; stem cell differentiation; subtelomeric heterochromatin formation; synaptic transmission, GABAergic","chromatin binding; chromatin DNA binding; DNA binding; histone H3K27 methyltransferase activity; histone H3K27 trimethyltransferase activity; histone lysine N-methyltransferase activity; histone methyltransferase activity; lncRNA binding; methyltransferase activity; primary miRNA binding; promoter-specific chromatin binding; protein binding; protein-lysine N-methyltransferase activity; ribonucleoprotein complex binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription corepressor activity; transcription corepressor binding; transferase activity","chromatin; chromatin silencing complex; chromosome, telomeric region; cytoplasm; ESC/E(Z) complex; nucleoplasm; nucleus; pericentric heterochromatin; pronucleus; synapse","Chromatin regulation / epigenetics","enhancer of zeste 2 polycomb repressive complex 2 subunit","http://www.ncbi.nlm.nih.gov/gene/?term=2146","2146","14056",null,null,null,null,"Q15910","Q61188","A0A8I5ZPT6","A0A8I3NL33","A0A286ZT87","A0A1D5RJQ2","GO:0000785; GO:0005677; GO:0000781; GO:0005737; GO:0035098; GO:0005654; GO:0005634; GO:0005721; GO:0045120; GO:0045202","GO:0003682; GO:0031490; GO:0003677; GO:0046976; GO:0140951; GO:0018024; GO:0042054; GO:0106222; GO:0008168; GO:0070878; GO:1990841; GO:0005515; GO:0016279; GO:0043021; GO:0003723; GO:0000978; GO:0000979; GO:0043565; GO:0000976; GO:0003714; GO:0001222; GO:0016740","GO:0030183; GO:0014898; GO:0070301; GO:0035984; GO:0021695; GO:0006325; GO:0006338; GO:0006306; GO:0009913; GO:0140718; GO:0070314; GO:0000082; GO:0030097; GO:0036333; GO:0031507; GO:0021766; GO:0070734; GO:0098532; GO:0016570; GO:0030216; GO:0097421; GO:0032259; GO:1900016; GO:0043433; GO:0045892; GO:0045605; GO:2000134; GO:0010629; GO:0045814; GO:0045617; GO:0048387; GO:2000737; GO:0051154; GO:0000122; GO:0034244; GO:1902808; GO:0008284; GO:1900006; GO:0010718; GO:0043547; GO:0043406; GO:0071902; GO:0071168; GO:0042127; GO:0042752; GO:0006355; GO:0010468; GO:0014013; GO:0050767; GO:0001932; GO:0006357; GO:0032355; GO:1904772; GO:0048511; GO:0014834; GO:0048863; GO:0031509; GO:0051932","PTHR45747:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3527|UniProtKB=Q15910"]
["Ezrin / Radixin / Moesin",null,"EZR","80, 75","rb",null,2,1,2.1,2.1,2,2,"# 1573",".cAMP., .CSP., .GPCR., .GPROT., .IMUF., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PI3K., .RTK., .SREME., .ST., .TCR., .TRASR.",null,"EZRIN","actin cytoskeleton reorganization; actin filament bundle assembly; astral microtubule organization; cellular response to cAMP; cortical microtubule organization; establishment of centrosome localization; establishment of endothelial barrier; establishment of epithelial cell apical/basal polarity; establishment or maintenance of apical/basal cell polarity; filopodium assembly; gland morphogenesis; intestinal D-glucose absorption; leukocyte cell-cell adhesion; membrane to membrane docking; microvillus assembly; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 production; negative regulation of p38MAPK cascade; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; phosphatidylinositol-mediated signaling; positive regulation of early endosome to late endosome transport; positive regulation of gene expression; positive regulation of multicellular organism growth; positive regulation of protein catabolic process; positive regulation of protein localization to early endosome; positive regulation of protein localization to plasma membrane; positive regulation of protein secretion; postsynaptic actin cytoskeleton organization; protein kinase A signaling; protein localization to cell cortex; protein localization to plasma membrane; protein-containing complex localization; receptor internalization; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of cell size; regulation of microvillus length; regulation of NIK/NF-kappaB signaling; regulation of organelle assembly; sphingosine-1-phosphate receptor signaling pathway; terminal web assembly","actin binding; actin filament binding; ATPase binding; cadherin binding; cell adhesion molecule binding; cytoskeletal protein binding; disordered domain specific binding; identical protein binding; microtubule binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase A binding; protein kinase A catalytic subunit binding; protein kinase A regulatory subunit binding; RNA binding; S100 protein binding","actin cytoskeleton; actin filament; adherens junction; apical part of cell; apical plasma membrane; basolateral plasma membrane; brush border; cell cortex; cell periphery; cell projection; ciliary basal body; cortical cytoskeleton; cytoplasm; cytoplasmic side of apical plasma membrane; cytoskeleton; cytosol; endosome; extracellular exosome; extracellular space; extrinsic component of membrane; fibrillar center; filopodium; focal adhesion; immunological synapse; membrane; microvillus; microvillus membrane; perinuclear region of cytoplasm; plasma membrane; plasma membrane raft; protein-containing complex; ruffle; ruffle membrane; uropod; vesicle",null,"ezrin","http://www.ncbi.nlm.nih.gov/gene/?term=7430","7430","22350","54319","484056",null,null,"P15311","P26040","P31977","A0A8I3MKE1","F1SB42","F6QSQ3","GO:0015629; GO:0005884; GO:0005912; GO:0045177; GO:0016324; GO:0016323; GO:0005903; GO:0005938; GO:0071944; GO:0042995; GO:0036064; GO:0030863; GO:0005737; GO:0098592; GO:0005856; GO:0005829; GO:0005768; GO:0070062; GO:0005615; GO:0019898; GO:0001650; GO:0030175; GO:0005925; GO:0001772; GO:0016020; GO:0005902; GO:0031528; GO:0048471; GO:0005886; GO:0044853; GO:0032991; GO:0001726; GO:0032587; GO:0001931; GO:0031982","GO:0003779; GO:0051015; GO:0051117; GO:0045296; GO:0050839; GO:0008092; GO:0097718; GO:0042802; GO:0008017; GO:0005515; GO:0008022; GO:0019904; GO:0051018; GO:0034236; GO:0034237; GO:0003723; GO:0044548","GO:0031532; GO:0051017; GO:0030953; GO:0071320; GO:0043622; GO:0051660; GO:0061028; GO:0045198; GO:0035088; GO:0046847; GO:0022612; GO:0001951; GO:0007159; GO:0022614; GO:0030033; GO:0070373; GO:0032703; GO:1903753; GO:0050860; GO:0000122; GO:0048015; GO:2000643; GO:0010628; GO:0040018; GO:0045732; GO:1902966; GO:1903078; GO:0050714; GO:0098974; GO:0010737; GO:0072697; GO:0072659; GO:0031503; GO:0031623; GO:0032956; GO:0008360; GO:0008361; GO:0032532; GO:1901222; GO:1902115; GO:0003376; GO:1902896","PTHR23281:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12691|UniProtKB=P15311"]
["Ezrin / Radixin / Moesin - phospho","Thr567/Thr564/Thr558","EZR","80, 75","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2586",".cAMP., .CSP., .GPCR., .GPROT., .IMUF., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PI3K., .RTK., .SREME., .ST., .TCR., .TRASR.",null,"EZRIN","actin cytoskeleton reorganization; actin filament bundle assembly; astral microtubule organization; cellular response to cAMP; cortical microtubule organization; establishment of centrosome localization; establishment of endothelial barrier; establishment of epithelial cell apical/basal polarity; establishment or maintenance of apical/basal cell polarity; filopodium assembly; gland morphogenesis; intestinal D-glucose absorption; leukocyte cell-cell adhesion; membrane to membrane docking; microvillus assembly; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 production; negative regulation of p38MAPK cascade; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; phosphatidylinositol-mediated signaling; positive regulation of early endosome to late endosome transport; positive regulation of gene expression; positive regulation of multicellular organism growth; positive regulation of protein catabolic process; positive regulation of protein localization to early endosome; positive regulation of protein localization to plasma membrane; positive regulation of protein secretion; postsynaptic actin cytoskeleton organization; protein kinase A signaling; protein localization to cell cortex; protein localization to plasma membrane; protein-containing complex localization; receptor internalization; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of cell size; regulation of microvillus length; regulation of NIK/NF-kappaB signaling; regulation of organelle assembly; sphingosine-1-phosphate receptor signaling pathway; terminal web assembly","actin binding; actin filament binding; ATPase binding; cadherin binding; cell adhesion molecule binding; cytoskeletal protein binding; disordered domain specific binding; identical protein binding; microtubule binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase A binding; protein kinase A catalytic subunit binding; protein kinase A regulatory subunit binding; RNA binding; S100 protein binding","actin cytoskeleton; actin filament; adherens junction; apical part of cell; apical plasma membrane; basolateral plasma membrane; brush border; cell cortex; cell periphery; cell projection; ciliary basal body; cortical cytoskeleton; cytoplasm; cytoplasmic side of apical plasma membrane; cytoskeleton; cytosol; endosome; extracellular exosome; extracellular space; extrinsic component of membrane; fibrillar center; filopodium; focal adhesion; immunological synapse; membrane; microvillus; microvillus membrane; perinuclear region of cytoplasm; plasma membrane; plasma membrane raft; protein-containing complex; ruffle; ruffle membrane; uropod; vesicle",null,"ezrin","http://www.ncbi.nlm.nih.gov/gene/?term=7430","7430","22350","54319","484056",null,null,"P15311","P26040","P31977","A0A8I3MKE1","F1SB42","F6QSQ3","GO:0015629; GO:0005884; GO:0005912; GO:0045177; GO:0016324; GO:0016323; GO:0005903; GO:0005938; GO:0071944; GO:0042995; GO:0036064; GO:0030863; GO:0005737; GO:0098592; GO:0005856; GO:0005829; GO:0005768; GO:0070062; GO:0005615; GO:0019898; GO:0001650; GO:0030175; GO:0005925; GO:0001772; GO:0016020; GO:0005902; GO:0031528; GO:0048471; GO:0005886; GO:0044853; GO:0032991; GO:0001726; GO:0032587; GO:0001931; GO:0031982","GO:0003779; GO:0051015; GO:0051117; GO:0045296; GO:0050839; GO:0008092; GO:0097718; GO:0042802; GO:0008017; GO:0005515; GO:0008022; GO:0019904; GO:0051018; GO:0034236; GO:0034237; GO:0003723; GO:0044548","GO:0031532; GO:0051017; GO:0030953; GO:0071320; GO:0043622; GO:0051660; GO:0061028; GO:0045198; GO:0035088; GO:0046847; GO:0022612; GO:0001951; GO:0007159; GO:0022614; GO:0030033; GO:0070373; GO:0032703; GO:1903753; GO:0050860; GO:0000122; GO:0048015; GO:2000643; GO:0010628; GO:0040018; GO:0045732; GO:1902966; GO:1903078; GO:0050714; GO:0098974; GO:0010737; GO:0072697; GO:0072659; GO:0031503; GO:0031623; GO:0032956; GO:0008360; GO:0008361; GO:0032532; GO:1901222; GO:1902115; GO:0003376; GO:1902896","PTHR23281:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12691|UniProtKB=P15311"]
["FABP4",null,"FABP4","15","rb",null,2,2,3,6,6,6,"# 1500",".CD., .CSP., .IMFR., .IMUR., .OP., .OPA., .OT., .ST., .TNF., .TRASR.",null,"FATTY ACID-BINDING PROTEIN, ADIPOCYTE","brown fat cell differentiation; cellular response to lithium ion; cellular response to tumor necrosis factor; cholesterol homeostasis; fatty acid transport; long-chain fatty acid transport; negative regulation of DNA-templated transcription; negative regulation of protein kinase activity; positive regulation of cold-induced thermogenesis; positive regulation of inflammatory response; response to bacterium; white fat cell differentiation","fatty acid binding; hormone receptor binding; lipid binding; long-chain fatty acid binding; long-chain fatty acid transporter activity","cytoplasm; cytosol; extracellular exosome; lipid droplet; nucleus","Metabolism","fatty acid binding protein 4","http://www.ncbi.nlm.nih.gov/gene/?term=2167","2167","11770",null,null,null,null,"P15090","P04117","A0A8I5Y7N0","A0A8I3RXJ7",null,null,"GO:0005737; GO:0005829; GO:0070062; GO:0005811; GO:0005634","GO:0005504; GO:0051427; GO:0008289; GO:0036041; GO:0005324","GO:0050873; GO:0071285; GO:0071356; GO:0042632; GO:0015908; GO:0015909; GO:0045892; GO:0006469; GO:0120162; GO:0050729; GO:0009617; GO:0050872","PTHR11955:SF83","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3559|UniProtKB=P15090"]
["FABP4",null,"FABP4","15","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2829",".CD., .CSP., .IMFR., .IMUR., .OP., .OPA., .OT., .ST., .TNF., .TRASR.",null,"FATTY ACID-BINDING PROTEIN, ADIPOCYTE","brown fat cell differentiation; cellular response to lithium ion; cellular response to tumor necrosis factor; cholesterol homeostasis; fatty acid transport; long-chain fatty acid transport; negative regulation of DNA-templated transcription; negative regulation of protein kinase activity; positive regulation of cold-induced thermogenesis; positive regulation of inflammatory response; response to bacterium; white fat cell differentiation","fatty acid binding; hormone receptor binding; lipid binding; long-chain fatty acid binding; long-chain fatty acid transporter activity","cytoplasm; cytosol; extracellular exosome; lipid droplet; nucleus","Metabolism","fatty acid binding protein 4","http://www.ncbi.nlm.nih.gov/gene/?term=2167","2167","11770",null,null,null,null,"P15090","P04117","A0A8I5Y7N0","A0A8I3RXJ7",null,null,"GO:0005737; GO:0005829; GO:0070062; GO:0005811; GO:0005634","GO:0005504; GO:0051427; GO:0008289; GO:0036041; GO:0005324","GO:0050873; GO:0071285; GO:0071356; GO:0042632; GO:0015908; GO:0015909; GO:0045892; GO:0006469; GO:0120162; GO:0050729; GO:0009617; GO:0050872","PTHR11955:SF83","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3559|UniProtKB=P15090"]
["FAK1",null,"PTK2","125","rb",null,2,1,1,7,8,8,"# 1823",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRAS., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","FOCAL ADHESION KINASE 1","angiogenesis; axon guidance; cell differentiation; cell migration; cell motility; cellular response to organic substance; detection of muscle stretch; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; innate immune response; integrin-mediated signaling pathway; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell-cell adhesion; netrin-activated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast migration; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of wound healing; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; regulation of cell population proliferation; regulation of cell shape; regulation of cellular component organization; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of multicellular organismal process; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","actin binding; ATP binding; integrin binding; JUN kinase binding; kinase activity; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity; SH2 domain binding; signaling receptor binding; transferase activity","anchoring junction; cell cortex; cell projection; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; intracellular membrane-bounded organelle; membrane; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; stress fiber","Tyrosine kinase / adaptor / cell-cell interaction","protein tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5747","5747","14083",null,null,null,null,"Q05397","P34152","A0A0G2KAT5","A0A8I3NDM5",null,"A0A1D5Q106","GO:0070161; GO:0005938; GO:0042995; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0031234; GO:0005925; GO:0043231; GO:0016020; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0001725","GO:0003779; GO:0005524; GO:0005178; GO:0008432; GO:0016301; GO:0140677; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0019903; GO:0004713; GO:0004725; GO:0042169; GO:0005102; GO:0016740","GO:0001525; GO:0007411; GO:0030154; GO:0016477; GO:0048870; GO:0071310; GO:0035995; GO:0048013; GO:0007173; GO:0030010; GO:0038096; GO:0060396; GO:0003007; GO:0045087; GO:0007229; GO:2000811; GO:0043066; GO:0022408; GO:0038007; GO:0018108; GO:0016310; GO:0001890; GO:0030335; GO:0008284; GO:0010634; GO:0010718; GO:0010763; GO:0010759; GO:0120041; GO:0043552; GO:0014068; GO:0045860; GO:0051897; GO:0001934; GO:2000060; GO:0090303; GO:0046777; GO:0006468; GO:0030155; GO:0033628; GO:0042127; GO:0008360; GO:0051128; GO:0051493; GO:0010594; GO:0010632; GO:0051893; GO:0043087; GO:0051239; GO:0045667; GO:0001932; GO:1900024; GO:0007172; GO:0007179; GO:0007169; GO:0048010","PTHR24418:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9611|UniProtKB=Q05397","P06959; P00056; P06664; P00034; P00005"]
["FAK1",null,"PTK2","125","rb",null,2,1,2,8,6,2,"# 0223",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","FOCAL ADHESION KINASE 1","angiogenesis; axon guidance; cell differentiation; cell migration; cell motility; cellular response to organic substance; detection of muscle stretch; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; innate immune response; integrin-mediated signaling pathway; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell-cell adhesion; netrin-activated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast migration; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of wound healing; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; regulation of cell population proliferation; regulation of cell shape; regulation of cellular component organization; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of multicellular organismal process; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","actin binding; ATP binding; integrin binding; JUN kinase binding; kinase activity; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity; SH2 domain binding; signaling receptor binding; transferase activity","anchoring junction; cell cortex; cell projection; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; intracellular membrane-bounded organelle; membrane; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; stress fiber","Tyrosine kinase / adaptor / cell-cell interaction","protein tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5747","5747","14083",null,null,null,null,"Q05397","P34152","A0A0G2KAT5","A0A8I3NDM5",null,"A0A1D5Q106","GO:0070161; GO:0005938; GO:0042995; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0031234; GO:0005925; GO:0043231; GO:0016020; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0001725","GO:0003779; GO:0005524; GO:0005178; GO:0008432; GO:0016301; GO:0140677; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0019903; GO:0004713; GO:0004725; GO:0042169; GO:0005102; GO:0016740","GO:0001525; GO:0007411; GO:0030154; GO:0016477; GO:0048870; GO:0071310; GO:0035995; GO:0048013; GO:0007173; GO:0030010; GO:0038096; GO:0060396; GO:0003007; GO:0045087; GO:0007229; GO:2000811; GO:0043066; GO:0022408; GO:0038007; GO:0018108; GO:0016310; GO:0001890; GO:0030335; GO:0008284; GO:0010634; GO:0010718; GO:0010763; GO:0010759; GO:0120041; GO:0043552; GO:0014068; GO:0045860; GO:0051897; GO:0001934; GO:2000060; GO:0090303; GO:0046777; GO:0006468; GO:0030155; GO:0033628; GO:0042127; GO:0008360; GO:0051128; GO:0051493; GO:0010594; GO:0010632; GO:0051893; GO:0043087; GO:0051239; GO:0045667; GO:0001932; GO:1900024; GO:0007172; GO:0007179; GO:0007169; GO:0048010","PTHR24418:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9611|UniProtKB=Q05397","P06959; P00056; P06664; P00034; P00005"]
["FAK1 - phospho","Tyr397","PTK2","125","rb",null,1,4,1.1000000000000001,8,8,8,"# 1448",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRAS., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","FOCAL ADHESION KINASE 1","angiogenesis; axon guidance; cell differentiation; cell migration; cell motility; cellular response to organic substance; detection of muscle stretch; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; innate immune response; integrin-mediated signaling pathway; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell-cell adhesion; netrin-activated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast migration; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of wound healing; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; regulation of cell population proliferation; regulation of cell shape; regulation of cellular component organization; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of multicellular organismal process; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","actin binding; ATP binding; integrin binding; JUN kinase binding; kinase activity; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity; SH2 domain binding; signaling receptor binding; transferase activity","anchoring junction; cell cortex; cell projection; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; intracellular membrane-bounded organelle; membrane; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; stress fiber","Tyrosine kinase / adaptor / cell-cell interaction","protein tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5747","5747","14083",null,null,null,null,"Q05397","P34152","A0A0G2KAT5","A0A8I3NDM5",null,"A0A1D5Q106","GO:0070161; GO:0005938; GO:0042995; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0031234; GO:0005925; GO:0043231; GO:0016020; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0001725","GO:0003779; GO:0005524; GO:0005178; GO:0008432; GO:0016301; GO:0140677; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0019903; GO:0004713; GO:0004725; GO:0042169; GO:0005102; GO:0016740","GO:0001525; GO:0007411; GO:0030154; GO:0016477; GO:0048870; GO:0071310; GO:0035995; GO:0048013; GO:0007173; GO:0030010; GO:0038096; GO:0060396; GO:0003007; GO:0045087; GO:0007229; GO:2000811; GO:0043066; GO:0022408; GO:0038007; GO:0018108; GO:0016310; GO:0001890; GO:0030335; GO:0008284; GO:0010634; GO:0010718; GO:0010763; GO:0010759; GO:0120041; GO:0043552; GO:0014068; GO:0045860; GO:0051897; GO:0001934; GO:2000060; GO:0090303; GO:0046777; GO:0006468; GO:0030155; GO:0033628; GO:0042127; GO:0008360; GO:0051128; GO:0051493; GO:0010594; GO:0010632; GO:0051893; GO:0043087; GO:0051239; GO:0045667; GO:0001932; GO:1900024; GO:0007172; GO:0007179; GO:0007169; GO:0048010","PTHR24418:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9611|UniProtKB=Q05397","P06959; P00056; P06664; P00034; P00005"]
["FAK1 - phospho","Tyr407","PTK2","125","rb",null,6,7,"n/a","n/a","n/a","n/a","# 1115",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","FOCAL ADHESION KINASE 1","angiogenesis; axon guidance; cell differentiation; cell migration; cell motility; cellular response to organic substance; detection of muscle stretch; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; innate immune response; integrin-mediated signaling pathway; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell-cell adhesion; netrin-activated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast migration; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of wound healing; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; regulation of cell population proliferation; regulation of cell shape; regulation of cellular component organization; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of multicellular organismal process; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","actin binding; ATP binding; integrin binding; JUN kinase binding; kinase activity; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity; SH2 domain binding; signaling receptor binding; transferase activity","anchoring junction; cell cortex; cell projection; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; intracellular membrane-bounded organelle; membrane; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; stress fiber","Tyrosine kinase / adaptor / cell-cell interaction","protein tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5747","5747","14083",null,null,null,null,"Q05397","P34152","A0A0G2KAT5","A0A8I3NDM5",null,"A0A1D5Q106","GO:0070161; GO:0005938; GO:0042995; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0031234; GO:0005925; GO:0043231; GO:0016020; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0001725","GO:0003779; GO:0005524; GO:0005178; GO:0008432; GO:0016301; GO:0140677; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0019903; GO:0004713; GO:0004725; GO:0042169; GO:0005102; GO:0016740","GO:0001525; GO:0007411; GO:0030154; GO:0016477; GO:0048870; GO:0071310; GO:0035995; GO:0048013; GO:0007173; GO:0030010; GO:0038096; GO:0060396; GO:0003007; GO:0045087; GO:0007229; GO:2000811; GO:0043066; GO:0022408; GO:0038007; GO:0018108; GO:0016310; GO:0001890; GO:0030335; GO:0008284; GO:0010634; GO:0010718; GO:0010763; GO:0010759; GO:0120041; GO:0043552; GO:0014068; GO:0045860; GO:0051897; GO:0001934; GO:2000060; GO:0090303; GO:0046777; GO:0006468; GO:0030155; GO:0033628; GO:0042127; GO:0008360; GO:0051128; GO:0051493; GO:0010594; GO:0010632; GO:0051893; GO:0043087; GO:0051239; GO:0045667; GO:0001932; GO:1900024; GO:0007172; GO:0007179; GO:0007169; GO:0048010","PTHR24418:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9611|UniProtKB=Q05397","P06959; P00056; P06664; P00034; P00005"]
["FAK1 - phospho","Tyr576/Tyr577","PTK2","125","rb",null,2,1,8,8,8,8,"# 0213",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","FOCAL ADHESION KINASE 1","angiogenesis; axon guidance; cell differentiation; cell migration; cell motility; cellular response to organic substance; detection of muscle stretch; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; innate immune response; integrin-mediated signaling pathway; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell-cell adhesion; netrin-activated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast migration; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of wound healing; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; regulation of cell population proliferation; regulation of cell shape; regulation of cellular component organization; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of multicellular organismal process; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","actin binding; ATP binding; integrin binding; JUN kinase binding; kinase activity; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity; SH2 domain binding; signaling receptor binding; transferase activity","anchoring junction; cell cortex; cell projection; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; intracellular membrane-bounded organelle; membrane; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; stress fiber","Tyrosine kinase / adaptor / cell-cell interaction","protein tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5747","5747","14083",null,null,null,null,"Q05397","P34152","A0A0G2KAT5","A0A8I3NDM5",null,"A0A1D5Q106","GO:0070161; GO:0005938; GO:0042995; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0031234; GO:0005925; GO:0043231; GO:0016020; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0001725","GO:0003779; GO:0005524; GO:0005178; GO:0008432; GO:0016301; GO:0140677; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0019903; GO:0004713; GO:0004725; GO:0042169; GO:0005102; GO:0016740","GO:0001525; GO:0007411; GO:0030154; GO:0016477; GO:0048870; GO:0071310; GO:0035995; GO:0048013; GO:0007173; GO:0030010; GO:0038096; GO:0060396; GO:0003007; GO:0045087; GO:0007229; GO:2000811; GO:0043066; GO:0022408; GO:0038007; GO:0018108; GO:0016310; GO:0001890; GO:0030335; GO:0008284; GO:0010634; GO:0010718; GO:0010763; GO:0010759; GO:0120041; GO:0043552; GO:0014068; GO:0045860; GO:0051897; GO:0001934; GO:2000060; GO:0090303; GO:0046777; GO:0006468; GO:0030155; GO:0033628; GO:0042127; GO:0008360; GO:0051128; GO:0051493; GO:0010594; GO:0010632; GO:0051893; GO:0043087; GO:0051239; GO:0045667; GO:0001932; GO:1900024; GO:0007172; GO:0007179; GO:0007169; GO:0048010","PTHR24418:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9611|UniProtKB=Q05397","P06959; P00056; P06664; P00034; P00005"]
["FAK1 - phospho","Tyr576/Tyr577","PTK2","125","rb",null,2.1,1,8,8,8,8,"# 1449",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRAS., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","FOCAL ADHESION KINASE 1","angiogenesis; axon guidance; cell differentiation; cell migration; cell motility; cellular response to organic substance; detection of muscle stretch; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; innate immune response; integrin-mediated signaling pathway; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell-cell adhesion; netrin-activated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast migration; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of wound healing; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; regulation of cell population proliferation; regulation of cell shape; regulation of cellular component organization; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of multicellular organismal process; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","actin binding; ATP binding; integrin binding; JUN kinase binding; kinase activity; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity; SH2 domain binding; signaling receptor binding; transferase activity","anchoring junction; cell cortex; cell projection; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; intracellular membrane-bounded organelle; membrane; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; stress fiber","Tyrosine kinase / adaptor / cell-cell interaction","protein tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5747","5747","14083",null,null,null,null,"Q05397","P34152","A0A0G2KAT5","A0A8I3NDM5",null,"A0A1D5Q106","GO:0070161; GO:0005938; GO:0042995; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0031234; GO:0005925; GO:0043231; GO:0016020; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0001725","GO:0003779; GO:0005524; GO:0005178; GO:0008432; GO:0016301; GO:0140677; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0019903; GO:0004713; GO:0004725; GO:0042169; GO:0005102; GO:0016740","GO:0001525; GO:0007411; GO:0030154; GO:0016477; GO:0048870; GO:0071310; GO:0035995; GO:0048013; GO:0007173; GO:0030010; GO:0038096; GO:0060396; GO:0003007; GO:0045087; GO:0007229; GO:2000811; GO:0043066; GO:0022408; GO:0038007; GO:0018108; GO:0016310; GO:0001890; GO:0030335; GO:0008284; GO:0010634; GO:0010718; GO:0010763; GO:0010759; GO:0120041; GO:0043552; GO:0014068; GO:0045860; GO:0051897; GO:0001934; GO:2000060; GO:0090303; GO:0046777; GO:0006468; GO:0030155; GO:0033628; GO:0042127; GO:0008360; GO:0051128; GO:0051493; GO:0010594; GO:0010632; GO:0051893; GO:0043087; GO:0051239; GO:0045667; GO:0001932; GO:1900024; GO:0007172; GO:0007179; GO:0007169; GO:0048010","PTHR24418:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9611|UniProtKB=Q05397","P06959; P00056; P06664; P00034; P00005"]
["FAK1 - phospho","Tyr861","PTK2","125","rb",null,4,1.1000000000000001,8,8,8,8,"# 0219",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","FOCAL ADHESION KINASE 1","angiogenesis; axon guidance; cell differentiation; cell migration; cell motility; cellular response to organic substance; detection of muscle stretch; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; innate immune response; integrin-mediated signaling pathway; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell-cell adhesion; netrin-activated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast migration; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of wound healing; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; regulation of cell population proliferation; regulation of cell shape; regulation of cellular component organization; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of multicellular organismal process; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","actin binding; ATP binding; integrin binding; JUN kinase binding; kinase activity; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity; SH2 domain binding; signaling receptor binding; transferase activity","anchoring junction; cell cortex; cell projection; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; intracellular membrane-bounded organelle; membrane; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; stress fiber","Tyrosine kinase / adaptor / cell-cell interaction","protein tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5747","5747","14083",null,null,null,null,"Q05397","P34152","A0A0G2KAT5","A0A8I3NDM5",null,"A0A1D5Q106","GO:0070161; GO:0005938; GO:0042995; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0031234; GO:0005925; GO:0043231; GO:0016020; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0001725","GO:0003779; GO:0005524; GO:0005178; GO:0008432; GO:0016301; GO:0140677; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0019903; GO:0004713; GO:0004725; GO:0042169; GO:0005102; GO:0016740","GO:0001525; GO:0007411; GO:0030154; GO:0016477; GO:0048870; GO:0071310; GO:0035995; GO:0048013; GO:0007173; GO:0030010; GO:0038096; GO:0060396; GO:0003007; GO:0045087; GO:0007229; GO:2000811; GO:0043066; GO:0022408; GO:0038007; GO:0018108; GO:0016310; GO:0001890; GO:0030335; GO:0008284; GO:0010634; GO:0010718; GO:0010763; GO:0010759; GO:0120041; GO:0043552; GO:0014068; GO:0045860; GO:0051897; GO:0001934; GO:2000060; GO:0090303; GO:0046777; GO:0006468; GO:0030155; GO:0033628; GO:0042127; GO:0008360; GO:0051128; GO:0051493; GO:0010594; GO:0010632; GO:0051893; GO:0043087; GO:0051239; GO:0045667; GO:0001932; GO:1900024; GO:0007172; GO:0007179; GO:0007169; GO:0048010","PTHR24418:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9611|UniProtKB=Q05397","P06959; P00056; P06664; P00034; P00005"]
["FAK1 - phospho","Tyr861","PTK2","125","rb",null,6,2,2.1,8,7,7,"TK # 085",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","FOCAL ADHESION KINASE 1","angiogenesis; axon guidance; cell differentiation; cell migration; cell motility; cellular response to organic substance; detection of muscle stretch; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; innate immune response; integrin-mediated signaling pathway; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell-cell adhesion; netrin-activated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast migration; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of wound healing; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; regulation of cell population proliferation; regulation of cell shape; regulation of cellular component organization; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of multicellular organismal process; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","actin binding; ATP binding; integrin binding; JUN kinase binding; kinase activity; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity; SH2 domain binding; signaling receptor binding; transferase activity","anchoring junction; cell cortex; cell projection; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; intracellular membrane-bounded organelle; membrane; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; stress fiber","Tyrosine kinase / adaptor / cell-cell interaction","protein tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5747","5747","14083",null,null,null,null,"Q05397","P34152","A0A0G2KAT5","A0A8I3NDM5",null,"A0A1D5Q106","GO:0070161; GO:0005938; GO:0042995; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0031234; GO:0005925; GO:0043231; GO:0016020; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0001725","GO:0003779; GO:0005524; GO:0005178; GO:0008432; GO:0016301; GO:0140677; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0019903; GO:0004713; GO:0004725; GO:0042169; GO:0005102; GO:0016740","GO:0001525; GO:0007411; GO:0030154; GO:0016477; GO:0048870; GO:0071310; GO:0035995; GO:0048013; GO:0007173; GO:0030010; GO:0038096; GO:0060396; GO:0003007; GO:0045087; GO:0007229; GO:2000811; GO:0043066; GO:0022408; GO:0038007; GO:0018108; GO:0016310; GO:0001890; GO:0030335; GO:0008284; GO:0010634; GO:0010718; GO:0010763; GO:0010759; GO:0120041; GO:0043552; GO:0014068; GO:0045860; GO:0051897; GO:0001934; GO:2000060; GO:0090303; GO:0046777; GO:0006468; GO:0030155; GO:0033628; GO:0042127; GO:0008360; GO:0051128; GO:0051493; GO:0010594; GO:0010632; GO:0051893; GO:0043087; GO:0051239; GO:0045667; GO:0001932; GO:1900024; GO:0007172; GO:0007179; GO:0007169; GO:0048010","PTHR24418:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9611|UniProtKB=Q05397","P06959; P00056; P06664; P00034; P00005"]
["FAK1 - phospho","Tyr925","PTK2","125","rb",null,4,2.1,8.1,8,8,8,"# 1450",".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRAS., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","FOCAL ADHESION KINASE 1","angiogenesis; axon guidance; cell differentiation; cell migration; cell motility; cellular response to organic substance; detection of muscle stretch; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; innate immune response; integrin-mediated signaling pathway; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cell-cell adhesion; netrin-activated signaling pathway; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast migration; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of wound healing; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; regulation of cell population proliferation; regulation of cell shape; regulation of cellular component organization; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of multicellular organismal process; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","actin binding; ATP binding; integrin binding; JUN kinase binding; kinase activity; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity; SH2 domain binding; signaling receptor binding; transferase activity","anchoring junction; cell cortex; cell projection; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; intracellular membrane-bounded organelle; membrane; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; stress fiber","Tyrosine kinase / adaptor / cell-cell interaction","protein tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5747","5747","14083",null,null,null,null,"Q05397","P34152","A0A0G2KAT5","A0A8I3NDM5",null,"A0A1D5Q106","GO:0070161; GO:0005938; GO:0042995; GO:0036064; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0031234; GO:0005925; GO:0043231; GO:0016020; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0001725","GO:0003779; GO:0005524; GO:0005178; GO:0008432; GO:0016301; GO:0140677; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0019903; GO:0004713; GO:0004725; GO:0042169; GO:0005102; GO:0016740","GO:0001525; GO:0007411; GO:0030154; GO:0016477; GO:0048870; GO:0071310; GO:0035995; GO:0048013; GO:0007173; GO:0030010; GO:0038096; GO:0060396; GO:0003007; GO:0045087; GO:0007229; GO:2000811; GO:0043066; GO:0022408; GO:0038007; GO:0018108; GO:0016310; GO:0001890; GO:0030335; GO:0008284; GO:0010634; GO:0010718; GO:0010763; GO:0010759; GO:0120041; GO:0043552; GO:0014068; GO:0045860; GO:0051897; GO:0001934; GO:2000060; GO:0090303; GO:0046777; GO:0006468; GO:0030155; GO:0033628; GO:0042127; GO:0008360; GO:0051128; GO:0051493; GO:0010594; GO:0010632; GO:0051893; GO:0043087; GO:0051239; GO:0045667; GO:0001932; GO:1900024; GO:0007172; GO:0007179; GO:0007169; GO:0048010","PTHR24418:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9611|UniProtKB=Q05397","P06959; P00056; P06664; P00034; P00005"]
["FAS",null,"FAS","50-40","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2047",".ALZ., .APO., .CANCER., .CANPTHW., .CD., .CSP., .DI., .FAS., .HEPB., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .OP., .OPA., .P53S., .RTK., .ST., .TNF.","p53 pathway; FAS signaling pathway; Apoptosis signaling pathway","TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6","activation-induced cell death of T cells; apoptotic process; cellular response to amino acid starvation; cellular response to hyperoxia; cellular response to mechanical stimulus; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; Fas signaling pathway; immune response; motor neuron apoptotic process; necroptotic signaling pathway; negative regulation of apoptotic process; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of protein phosphorylation; protein-containing complex assembly; regulation of apoptotic process; regulation of stress-activated MAPK cascade; signal transduction; tumor necrosis factor-mediated signaling pathway","calmodulin binding; identical protein binding; kinase binding; protein binding; signaling receptor activity; transmembrane signaling receptor activity; tumor necrosis factor receptor activity","CD95 death-inducing signaling complex; cell surface; cellular anatomical entity; cytosol; death-inducing signaling complex; external side of plasma membrane; extracellular exosome; extracellular region; membrane; membrane raft; nuclear body; plasma membrane","Immunology / inflammation","Fas cell surface death receptor","http://www.ncbi.nlm.nih.gov/gene/?term=355","355","14102",null,"486469",null,null,"P25445","P25446","A0A8I5ZN15","A0A8I3Q9L2","A0A5G2QRG0",null,"GO:0031265; GO:0009986; GO:0110165; GO:0005829; GO:0031264; GO:0009897; GO:0070062; GO:0005576; GO:0016020; GO:0045121; GO:0016604; GO:0005886","GO:0005516; GO:0042802; GO:0019900; GO:0005515; GO:0038023; GO:0004888; GO:0005031","GO:0006924; GO:0006915; GO:0034198; GO:0071455; GO:0071260; GO:0097191; GO:0097192; GO:0036337; GO:0006955; GO:0097049; GO:0097527; GO:0043066; GO:0043065; GO:2001235; GO:2001269; GO:0001934; GO:0065003; GO:0042981; GO:0032872; GO:0007165; GO:0033209","PTHR46874:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11920|UniProtKB=P25445","P00059; P00020; P00006"]
["FASN",null,"FASN","273","rb",null,1,1,"n/a","n/a","n/a","n/a","# 1652",".AMPK., .CSP., .IMFR., .IMUR., .INS., .OP., .SREME.",null,"FATTY ACID SYNTHASE","biosynthetic process; cellular response to interleukin-4; establishment of endothelial intestinal barrier; ether lipid biosynthetic process; fatty acid biosynthetic process; fatty acid metabolic process; glandular epithelial cell development; inflammatory response; lipid metabolic process; mammary gland development; metabolic process; modulation by host of viral process; monocyte differentiation; neutrophil differentiation; osteoblast differentiation; tissue development","(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; acyl-[acyl-carrier-protein] hydrolase activity; acyltransferase activity; cadherin binding; catalytic activity; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; fatty acid synthase activity; hydrolase activity; lyase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; oxidoreductase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; phosphopantetheine binding; protein binding; RNA binding; S-malonyltransferase activity; transferase activity","cytoplasm; cytosol; extracellular exosome; glycogen granule; Golgi apparatus; melanosome; membrane; plasma membrane",null,"fatty acid synthase","http://www.ncbi.nlm.nih.gov/gene/?term=2194","2194","14104","50671",null,null,null,"P49327","P19096","P12785","A0A8I3N2Z7","I3LC73","A0A5F7ZMN2","GO:0005737; GO:0005829; GO:0070062; GO:0042587; GO:0005794; GO:0042470; GO:0016020; GO:0005886","GO:0008659; GO:0004313; GO:0004314; GO:0019171; GO:0008693; GO:0047451; GO:0004317; GO:0004316; GO:0004315; GO:0016297; GO:0016746; GO:0045296; GO:0003824; GO:0047117; GO:0004312; GO:0016787; GO:0016829; GO:0016295; GO:0004320; GO:0016491; GO:0016296; GO:0031177; GO:0005515; GO:0003723; GO:0016419; GO:0016740","GO:0009058; GO:0071353; GO:0090557; GO:0008611; GO:0006633; GO:0006631; GO:0002068; GO:0006954; GO:0006629; GO:0030879; GO:0008152; GO:0044788; GO:0030224; GO:0030223; GO:0001649; GO:0009888","PTHR43775:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3594|UniProtKB=P49327"]
["FAT 10",null,"UBD","18","rb",null,7,6,4,4,4,4,"# 0543",".APO., .CCP., .CCY., .CD., .CSP., .IIR., .IMUF., .IMUR., .NFKB., .OP., .OT., .UBI.",null,"UBIQUITIN D","aggresome assembly; myeloid dendritic cell differentiation; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein modification by small protein conjugation; protein ubiquitination; proteolysis; regulation of mitotic cell cycle phase transition; response to tumor necrosis factor; response to type II interferon; ubiquitin-dependent protein catabolic process","proteasome binding; protein binding","aggresome; cytoplasm; cytosol; fibrillar center; nucleoplasm; nucleus",null,"ubiquitin D","http://www.ncbi.nlm.nih.gov/gene/?term=10537","10537","24108",null,null,null,null,"O15205","P63072","A0A8I6AEG9",null,"A0A5G2QLG9",null,"GO:0016235; GO:0005737; GO:0005829; GO:0001650; GO:0005654; GO:0005634","GO:0070628; GO:0005515","GO:0070842; GO:0043011; GO:0043065; GO:0043123; GO:0032446; GO:0016567; GO:0006508; GO:1901990; GO:0034612; GO:0034341; GO:0006511","PTHR47731:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18795|UniProtKB=O15205"]
["FBXO25",null,"FBXO25","42","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1423",".CSP., .FOXO., .OP., .OPA., .OT., .UBI.",null,"F-BOX ONLY PROTEIN 25","protein ubiquitination","actin binding; ubiquitin-protein transferase activity","cytoplasm; nucleolus; nucleus; SCF ubiquitin ligase complex; ubiquitin ligase complex","Ubiquitination","F-box protein 25","http://www.ncbi.nlm.nih.gov/gene/?term=26260","26260","66822",null,null,null,"716139","Q8TCJ0","Q9D2Y6","A0A8I6ARL8","A0A8I3NPG5","A0A286ZN23","F6U004","GO:0005737; GO:0005730; GO:0005634; GO:0019005; GO:0000151","GO:0003779; GO:0004842","GO:0016567","PTHR13123:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13596|UniProtKB=Q8TCJ0"]
["FDPS (farnesyl diphosphate synthase)",null,"FDPS","48","rb",null,2,2,6,6,6,6,"# 1151",null,"Cholesterol biosynthesis","FARNESYL PYROPHOSPHATE SYNTHASE","cholesterol biosynthetic process; cholesterol metabolic process; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; isoprenoid biosynthetic process; lipid metabolic process; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process","dimethylallyltranstransferase activity; geranyltranstransferase activity; metal ion binding; protein binding; RNA binding; transferase activity; transferase activity, transferring alkyl or aryl (other than methyl) groups","cytoplasm; cytosol; nucleoplasm","Isoprenoid biosynthesis","farnesyl diphosphate synthase","http://www.ncbi.nlm.nih.gov/gene/?term=2224","2224","110196",null,"480129","100156361","717761","P14324","Q920E5","A0A0G2JXT3","A0A8I3NF82","A0A287AWX3","F7FI27","GO:0005737; GO:0005829; GO:0005654","GO:0004161; GO:0004337; GO:0046872; GO:0005515; GO:0003723; GO:0016740; GO:0016765","GO:0006695; GO:0008203; GO:0045337; GO:0033384; GO:0008299; GO:0006629; GO:0006694; GO:0008202; GO:0016126","PTHR11525:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3631|UniProtKB=P14324","P00014"]
["FGF receptor (pan) - phospho","Tyr653/Tyr654","FGFR1, FGFR2, FGFR3, FGFR4","145, 120","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1498",".ANG., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .DRR., .EGFR., .FGFR., .HHSP., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .ST., .STAT., .TRASR., .WNT.","FGF signaling pathway; Angiogenesis","FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4","cell migration; chordate embryonic development; epithelial to mesenchymal transition; fibroblast growth factor receptor signaling pathway; MAPK cascade; neuron migration; peptidyl-tyrosine phosphorylation; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of endothelial cell chemotaxis to fibroblast growth factor; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of neuron differentiation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase activity; positive regulation of phospholipase C activity; positive regulation of protein kinase B signaling; positive regulation of vascular endothelial cell proliferation; protein autophosphorylation; protein phosphorylation; regulation of cell differentiation; regulation of extrinsic apoptotic signaling pathway in absence of ligand; skeletal system development; skeletal system morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; angiogenesis; animal organ morphogenesis; apoptotic process; axonogenesis; bone development; bone mineralization; bone morphogenesis; branch elongation involved in salivary gland morphogenesis; branching involved in labyrinthine layer morphogenesis; branching involved in prostate gland morphogenesis; branching involved in salivary gland morphogenesis; branching morphogenesis of a nerve; bud elongation involved in lung branching; cell fate commitment; cell-cell signaling; cellular response to fibroblast growth factor stimulus; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; digestive tract development; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic organ development; embryonic organ morphogenesis; embryonic pattern specification; endochondral bone growth; epidermis morphogenesis; epithelial cell differentiation; epithelial cell proliferation involved in salivary gland morphogenesis; fibroblast growth factor receptor signaling pathway involved in hemopoiesis; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; gland morphogenesis; hair follicle morphogenesis; in utero embryonic development; inner ear morphogenesis; lacrimal gland development; lateral sprouting from an epithelium; limb bud formation; lung alveolus development; lung development; lung lobe morphogenesis; lung-associated mesenchyme development; mammary gland bud formation; membranous septum morphogenesis; mesenchymal cell differentiation; mesenchymal cell differentiation involved in lung development; mesenchymal cell proliferation involved in lung development; mesodermal cell differentiation; midbrain development; morphogenesis of embryonic epithelium; negative regulation of epithelial cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of transcription by RNA polymerase II; odontogenesis; orbitofrontal cortex development; organ growth; otic vesicle formation; outflow tract septum morphogenesis; positive regulation of canonical Wnt signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell division; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of mesenchymal cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of Wnt signaling pathway; post-embryonic development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; prostate gland morphogenesis; pyramidal neuron development; regulation of ERK1 and ERK2 cascade; regulation of morphogenesis of a branching structure; regulation of osteoblast differentiation; regulation of osteoblast proliferation; regulation of smooth muscle cell differentiation; regulation of smoothened signaling pathway; reproductive structure development; response to ethanol; response to lipopolysaccharide; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; ureteric bud development; ventricular cardiac muscle tissue morphogenesis; ventricular zone neuroblast division; wound healing; bone maturation; chondrocyte differentiation; chondrocyte proliferation; endochondral ossification; fibroblast growth factor receptor apoptotic signaling pathway; negative regulation of developmental growth; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of tyrosine phosphorylation of STAT protein; cholesterol homeostasis; glucose homeostasis; phosphate ion homeostasis; positive regulation of catalytic activity; positive regulation of DNA biosynthetic process; positive regulation of gene expression; positive regulation of proteolysis; regulation of bile acid biosynthetic process; regulation of extracellular matrix disassembly; regulation of lipid metabolic process; response to bile acid","ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; receptor-receptor interaction; transferase activity; transmembrane receptor protein tyrosine kinase activity","cytoplasm; cytoplasmic vesicle; cytosol; extracellular region; membrane; nucleus; plasma membrane; receptor complex; cell cortex; cell surface; collagen-containing extracellular matrix; excitatory synapse; Golgi apparatus; endoplasmic reticulum; focal adhesion; transport vesicle; cell-cell junction; endosome","Tyrosine kinase / adaptor","fibroblast growth factor receptor 1; fibroblast growth factor receptor 2; fibroblast growth factor receptor 3; fibroblast growth factor receptor 4","http://www.ncbi.nlm.nih.gov/gene/?term=2260, http://www.ncbi.nlm.nih.gov/gene/?term=2263, http://www.ncbi.nlm.nih.gov/gene/?term=2261, http://www.ncbi.nlm.nih.gov/gene/?term=2264","2260, 2263, 2261, 2264","14182, NA, 14186","NA, 25022, 84489","NA, 489095","NA, 100127133","700126, 715949, 712829","P11362, P21802, P22607, P22455","P16092, D3Z5M8, A0A0J9YTQ5, A0A0R4IZY3","A0A8J8YIL8, F1LN06, A0A0G2K210, A0A8I6ANB5","A0A8I3NAV3, A0A8I3NZY5, A0A8I3NFU5, A0A8I3NCC1","A0A5G2QI33, A0A5G2R7G6, A0A287A7Y1, F1S3B8","A0A1D5Q279, A0A1D5QFH7, F7FZR9","GO:0005737; GO:0031410; GO:0005829; GO:0005576; GO:0016020; GO:0005634; GO:0005886; GO:0043235; GO:0005938; GO:0009986; GO:0062023; GO:0060076; GO:0005794; GO:0005783; GO:0005925; GO:0030133; GO:0005911; GO:0005768","GO:0005524; GO:0017134; GO:0005007; GO:0008201; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0004713; GO:0090722; GO:0016740; GO:0004714","GO:0016477; GO:0043009; GO:0001837; GO:0008543; GO:0000165; GO:0001764; GO:0018108; GO:0048015; GO:0016310; GO:0043536; GO:0045597; GO:0008284; GO:2000546; GO:0033674; GO:0043406; GO:0043410; GO:0045666; GO:0014068; GO:0010518; GO:0010863; GO:0051897; GO:1905564; GO:0046777; GO:0006468; GO:0045595; GO:2001239; GO:0001501; GO:0048705; GO:0007169; GO:0001525; GO:0009887; GO:0006915; GO:0007409; GO:0060348; GO:0030282; GO:0060349; GO:0060667; GO:0060670; GO:0060442; GO:0060445; GO:0048755; GO:0060449; GO:0045165; GO:0007267; GO:0044344; GO:0071300; GO:0071560; GO:0048565; GO:0048701; GO:0048557; GO:0048568; GO:0048562; GO:0009880; GO:0003416; GO:0048730; GO:0030855; GO:0060664; GO:0035603; GO:0060595; GO:0035602; GO:0035607; GO:0035604; GO:0022612; GO:0031069; GO:0001701; GO:0042472; GO:0032808; GO:0060601; GO:0060174; GO:0048286; GO:0030324; GO:0060463; GO:0060484; GO:0060615; GO:0003149; GO:0048762; GO:0060915; GO:0060916; GO:0048333; GO:0030901; GO:0016331; GO:0050680; GO:0010839; GO:0000122; GO:0042476; GO:0021769; GO:0035265; GO:0030916; GO:0003148; GO:0090263; GO:0060045; GO:0045787; GO:0051781; GO:0050679; GO:0060501; GO:0070374; GO:0002053; GO:0048661; GO:0045944; GO:0030177; GO:0009791; GO:0060527; GO:0060523; GO:0060512; GO:0021860; GO:0070372; GO:0060688; GO:0045667; GO:0033688; GO:0051150; GO:0008589; GO:0048608; GO:0045471; GO:0032496; GO:0060529; GO:0001657; GO:0055010; GO:0021847; GO:0042060; GO:0070977; GO:0002062; GO:0035988; GO:0001958; GO:1902178; GO:0048640; GO:0043552; GO:0042531; GO:0042632; GO:0042593; GO:0055062; GO:0043085; GO:2000573; GO:0010628; GO:0045862; GO:0070857; GO:0010715; GO:0019216; GO:1903412","PTHR24416:SF131; PTHR24416:SF130; PTHR24416:SF505; PTHR24416:SF343","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3688|UniProtKB=P11362; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3689|UniProtKB=P21802; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3690|UniProtKB=P22607; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3691|UniProtKB=P22455","P00021; P00005"]
["FGF receptor 1",null,"FGFR1","145, 120, 92","rb",null,2,4,4,4,4,4,"# 1905",".ANG., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .FGFR., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .ST.","FGF signaling pathway; Angiogenesis","FIBROBLAST GROWTH FACTOR RECEPTOR 1","cell migration; chordate embryonic development; epithelial to mesenchymal transition; fibroblast growth factor receptor signaling pathway; MAPK cascade; neuron migration; peptidyl-tyrosine phosphorylation; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of endothelial cell chemotaxis to fibroblast growth factor; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of neuron differentiation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase activity; positive regulation of phospholipase C activity; positive regulation of protein kinase B signaling; positive regulation of vascular endothelial cell proliferation; protein autophosphorylation; protein phosphorylation; regulation of cell differentiation; regulation of extrinsic apoptotic signaling pathway in absence of ligand; skeletal system development; skeletal system morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; receptor-receptor interaction; transferase activity; transmembrane receptor protein tyrosine kinase activity","cytoplasm; cytoplasmic vesicle; cytosol; extracellular region; membrane; nucleus; plasma membrane; receptor complex","Tyrosine kinase / adaptor","fibroblast growth factor receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=2260","2260","14182",null,null,null,"700126","P11362","P16092","A0A8J8YIL8","A0A8I3NAV3","A0A5G2QI33","A0A1D5Q279","GO:0005737; GO:0031410; GO:0005829; GO:0005576; GO:0016020; GO:0005634; GO:0005886; GO:0043235","GO:0005524; GO:0017134; GO:0005007; GO:0008201; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0004713; GO:0090722; GO:0016740; GO:0004714","GO:0016477; GO:0043009; GO:0001837; GO:0008543; GO:0000165; GO:0001764; GO:0018108; GO:0048015; GO:0016310; GO:0043536; GO:0045597; GO:0008284; GO:2000546; GO:0033674; GO:0043406; GO:0043410; GO:0045666; GO:0014068; GO:0010518; GO:0010863; GO:0051897; GO:1905564; GO:0046777; GO:0006468; GO:0045595; GO:2001239; GO:0001501; GO:0048705; GO:0007169","PTHR24416:SF131","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3688|UniProtKB=P11362","P00021; P00005"]
["FGF receptor 2",null,"FGFR2","145, 120, 92","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1402",".ANG., .APO., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DRR., .EGFR., .FGFR., .HHSP., .MAPK., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .ST., .TRASR., .WNT.","FGF signaling pathway","FIBROBLAST GROWTH FACTOR RECEPTOR 2","angiogenesis; animal organ morphogenesis; apoptotic process; axonogenesis; bone development; bone mineralization; bone morphogenesis; branch elongation involved in salivary gland morphogenesis; branching involved in labyrinthine layer morphogenesis; branching involved in prostate gland morphogenesis; branching involved in salivary gland morphogenesis; branching morphogenesis of a nerve; bud elongation involved in lung branching; cell fate commitment; cell-cell signaling; cellular response to fibroblast growth factor stimulus; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; digestive tract development; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic organ development; embryonic organ morphogenesis; embryonic pattern specification; endochondral bone growth; epidermis morphogenesis; epithelial cell differentiation; epithelial cell proliferation involved in salivary gland morphogenesis; epithelial to mesenchymal transition; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway involved in hemopoiesis; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; gland morphogenesis; hair follicle morphogenesis; in utero embryonic development; inner ear morphogenesis; lacrimal gland development; lateral sprouting from an epithelium; limb bud formation; lung alveolus development; lung development; lung lobe morphogenesis; lung-associated mesenchyme development; mammary gland bud formation; membranous septum morphogenesis; mesenchymal cell differentiation; mesenchymal cell differentiation involved in lung development; mesenchymal cell proliferation involved in lung development; mesodermal cell differentiation; midbrain development; morphogenesis of embryonic epithelium; negative regulation of epithelial cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of transcription by RNA polymerase II; odontogenesis; orbitofrontal cortex development; organ growth; otic vesicle formation; outflow tract septum morphogenesis; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell division; positive regulation of cell population proliferation; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of kinase activity; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of phospholipase activity; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of Wnt signaling pathway; post-embryonic development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; prostate gland morphogenesis; protein autophosphorylation; protein phosphorylation; pyramidal neuron development; regulation of ERK1 and ERK2 cascade; regulation of morphogenesis of a branching structure; regulation of osteoblast differentiation; regulation of osteoblast proliferation; regulation of smooth muscle cell differentiation; regulation of smoothened signaling pathway; reproductive structure development; response to ethanol; response to lipopolysaccharide; skeletal system morphogenesis; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; transmembrane receptor protein tyrosine kinase signaling pathway; ureteric bud development; ventricular cardiac muscle tissue morphogenesis; ventricular zone neuroblast division; wound healing","ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","cell cortex; cell surface; collagen-containing extracellular matrix; cytoplasm; cytoplasmic vesicle; excitatory synapse; extracellular region; Golgi apparatus; membrane; nucleus; plasma membrane; receptor complex","Tyrosine kinase / adaptor","fibroblast growth factor receptor 2","http://www.ncbi.nlm.nih.gov/gene/?term=2263","2263",null,"25022",null,null,"715949","P21802","D3Z5M8","F1LN06","A0A8I3NZY5","A0A5G2R7G6","A0A1D5QFH7","GO:0005938; GO:0009986; GO:0062023; GO:0005737; GO:0031410; GO:0060076; GO:0005576; GO:0005794; GO:0016020; GO:0005634; GO:0005886; GO:0043235","GO:0005524; GO:0017134; GO:0005007; GO:0008201; GO:0016301; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0004713; GO:0016740; GO:0004714","GO:0001525; GO:0009887; GO:0006915; GO:0007409; GO:0060348; GO:0030282; GO:0060349; GO:0060667; GO:0060670; GO:0060442; GO:0060445; GO:0048755; GO:0060449; GO:0045165; GO:0007267; GO:0044344; GO:0071300; GO:0071560; GO:0048565; GO:0048701; GO:0048557; GO:0048568; GO:0048562; GO:0009880; GO:0003416; GO:0048730; GO:0030855; GO:0060664; GO:0001837; GO:0008543; GO:0035603; GO:0060595; GO:0035602; GO:0035607; GO:0035604; GO:0022612; GO:0031069; GO:0001701; GO:0042472; GO:0032808; GO:0060601; GO:0060174; GO:0048286; GO:0030324; GO:0060463; GO:0060484; GO:0060615; GO:0003149; GO:0048762; GO:0060915; GO:0060916; GO:0048333; GO:0030901; GO:0016331; GO:0050680; GO:0010839; GO:0000122; GO:0042476; GO:0021769; GO:0035265; GO:0030916; GO:0003148; GO:0018108; GO:0016310; GO:0090263; GO:0060045; GO:0045787; GO:0051781; GO:0008284; GO:0050679; GO:0060501; GO:0070374; GO:0033674; GO:0043410; GO:0002053; GO:0010518; GO:0048661; GO:0045944; GO:0030177; GO:0009791; GO:0060527; GO:0060523; GO:0060512; GO:0046777; GO:0006468; GO:0021860; GO:0070372; GO:0060688; GO:0045667; GO:0033688; GO:0051150; GO:0008589; GO:0048608; GO:0045471; GO:0032496; GO:0048705; GO:0060529; GO:0007169; GO:0001657; GO:0055010; GO:0021847; GO:0042060","PTHR24416:SF130","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3689|UniProtKB=P21802","P00021"]
["FGF receptor 2",null,"FGFR2","145, 92","rb",null,1,8,"n/a","n/a","n/a","n/a","# 3058",".ANG., .APO., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DRR., .EGFR., .FGFR., .HHSP., .MAPK., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .ST., .TRASR., .WNT.","FGF signaling pathway","FIBROBLAST GROWTH FACTOR RECEPTOR 2","angiogenesis; animal organ morphogenesis; apoptotic process; axonogenesis; bone development; bone mineralization; bone morphogenesis; branch elongation involved in salivary gland morphogenesis; branching involved in labyrinthine layer morphogenesis; branching involved in prostate gland morphogenesis; branching involved in salivary gland morphogenesis; branching morphogenesis of a nerve; bud elongation involved in lung branching; cell fate commitment; cell-cell signaling; cellular response to fibroblast growth factor stimulus; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; digestive tract development; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic organ development; embryonic organ morphogenesis; embryonic pattern specification; endochondral bone growth; epidermis morphogenesis; epithelial cell differentiation; epithelial cell proliferation involved in salivary gland morphogenesis; epithelial to mesenchymal transition; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway involved in hemopoiesis; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; gland morphogenesis; hair follicle morphogenesis; in utero embryonic development; inner ear morphogenesis; lacrimal gland development; lateral sprouting from an epithelium; limb bud formation; lung alveolus development; lung development; lung lobe morphogenesis; lung-associated mesenchyme development; mammary gland bud formation; membranous septum morphogenesis; mesenchymal cell differentiation; mesenchymal cell differentiation involved in lung development; mesenchymal cell proliferation involved in lung development; mesodermal cell differentiation; midbrain development; morphogenesis of embryonic epithelium; negative regulation of epithelial cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of transcription by RNA polymerase II; odontogenesis; orbitofrontal cortex development; organ growth; otic vesicle formation; outflow tract septum morphogenesis; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell division; positive regulation of cell population proliferation; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of kinase activity; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of phospholipase activity; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of Wnt signaling pathway; post-embryonic development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; prostate gland morphogenesis; protein autophosphorylation; protein phosphorylation; pyramidal neuron development; regulation of ERK1 and ERK2 cascade; regulation of morphogenesis of a branching structure; regulation of osteoblast differentiation; regulation of osteoblast proliferation; regulation of smooth muscle cell differentiation; regulation of smoothened signaling pathway; reproductive structure development; response to ethanol; response to lipopolysaccharide; skeletal system morphogenesis; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; transmembrane receptor protein tyrosine kinase signaling pathway; ureteric bud development; ventricular cardiac muscle tissue morphogenesis; ventricular zone neuroblast division; wound healing","ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","cell cortex; cell surface; collagen-containing extracellular matrix; cytoplasm; cytoplasmic vesicle; excitatory synapse; extracellular region; Golgi apparatus; membrane; nucleus; plasma membrane; receptor complex","Tyrosine kinase / adaptor","fibroblast growth factor receptor 2","http://www.ncbi.nlm.nih.gov/gene/?term=2263","2263",null,"25022",null,null,"715949","P21802","D3Z5M8","F1LN06","A0A8I3NZY5","A0A5G2R7G6","A0A1D5QFH7","GO:0005938; GO:0009986; GO:0062023; GO:0005737; GO:0031410; GO:0060076; GO:0005576; GO:0005794; GO:0016020; GO:0005634; GO:0005886; GO:0043235","GO:0005524; GO:0017134; GO:0005007; GO:0008201; GO:0016301; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0004713; GO:0016740; GO:0004714","GO:0001525; GO:0009887; GO:0006915; GO:0007409; GO:0060348; GO:0030282; GO:0060349; GO:0060667; GO:0060670; GO:0060442; GO:0060445; GO:0048755; GO:0060449; GO:0045165; GO:0007267; GO:0044344; GO:0071300; GO:0071560; GO:0048565; GO:0048701; GO:0048557; GO:0048568; GO:0048562; GO:0009880; GO:0003416; GO:0048730; GO:0030855; GO:0060664; GO:0001837; GO:0008543; GO:0035603; GO:0060595; GO:0035602; GO:0035607; GO:0035604; GO:0022612; GO:0031069; GO:0001701; GO:0042472; GO:0032808; GO:0060601; GO:0060174; GO:0048286; GO:0030324; GO:0060463; GO:0060484; GO:0060615; GO:0003149; GO:0048762; GO:0060915; GO:0060916; GO:0048333; GO:0030901; GO:0016331; GO:0050680; GO:0010839; GO:0000122; GO:0042476; GO:0021769; GO:0035265; GO:0030916; GO:0003148; GO:0018108; GO:0016310; GO:0090263; GO:0060045; GO:0045787; GO:0051781; GO:0008284; GO:0050679; GO:0060501; GO:0070374; GO:0033674; GO:0043410; GO:0002053; GO:0010518; GO:0048661; GO:0045944; GO:0030177; GO:0009791; GO:0060527; GO:0060523; GO:0060512; GO:0046777; GO:0006468; GO:0021860; GO:0070372; GO:0060688; GO:0045667; GO:0033688; GO:0051150; GO:0008589; GO:0048608; GO:0045471; GO:0032496; GO:0048705; GO:0060529; GO:0007169; GO:0001657; GO:0055010; GO:0021847; GO:0042060","PTHR24416:SF130","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3689|UniProtKB=P21802","P00021"]
["FGF-1",null,"FGF1","17","rb",null,2,2,8,1,2.1,1.1000000000000001,"# 1562",".ANG., .BRC., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .DEV., .FGFR., .HIPPO., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR.","FGF signaling pathway; Angiogenesis","FIBROBLAST GROWTH FACTOR 1","activation of protein kinase B activity; anatomical structure morphogenesis; angiogenesis; animal organ morphogenesis; branch elongation involved in ureteric bud branching; cell differentiation; cellular response to heat; epithelial cell proliferation; fibroblast growth factor receptor signaling pathway; lung development; mesonephric epithelium development; organ induction; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cholesterol biosynthetic process; positive regulation of endothelial cell migration; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of hepatocyte proliferation; positive regulation of intracellular signal transduction; positive regulation of MAP kinase activity; positive regulation of protein phosphorylation; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; regulation of cell migration; regulation of endothelial cell chemotaxis to fibroblast growth factor; regulation of endothelial tube morphogenesis; signal transduction; wound healing","fibroblast growth factor receptor binding; growth factor activity; heparin binding; Hsp70 protein binding; integrin binding; protein binding; S100 protein binding","cell cortex; cytoplasm; cytosol; extracellular matrix; extracellular region; extracellular space; nucleolus; nucleoplasm; nucleus","Growth factor","fibroblast growth factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=2246","2246","14164","25317",null,null,null,"P05230","P61148","P61149",null,"A0A287A109",null,"GO:0005938; GO:0005737; GO:0005829; GO:0031012; GO:0005576; GO:0005615; GO:0005730; GO:0005654; GO:0005634","GO:0005104; GO:0008083; GO:0008201; GO:0030544; GO:0005178; GO:0005515; GO:0044548","GO:0032148; GO:0009653; GO:0001525; GO:0009887; GO:0060681; GO:0030154; GO:0034605; GO:0050673; GO:0008543; GO:0030324; GO:0072163; GO:0001759; GO:0045766; GO:0051781; GO:0030335; GO:0008284; GO:0045542; GO:0010595; GO:0050679; GO:0070374; GO:0010628; GO:2000347; GO:1902533; GO:0043406; GO:0001934; GO:1903672; GO:0045944; GO:0030334; GO:2000544; GO:1901509; GO:0007165; GO:0042060","PTHR11486:SF86","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3665|UniProtKB=P05230","P00021; P00005"]
["FGF-10",null,"FGF10","23","gt",null,6,2,"n/a","n/a","n/a","n/a","# 0986",".ANG., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .DREP., .FGFR., .HHSP., .MAPK., .MEL., .MIG., .NOTCH., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TD., .TMAT., .TRASR., .VEGFS., .WNT.","FGF signaling pathway","FIBROBLAST GROWTH FACTOR 10","actin cytoskeleton reorganization; angiogenesis; animal organ formation; animal organ morphogenesis; blood vessel morphogenesis; blood vessel remodeling; branch elongation involved in salivary gland morphogenesis; branching involved in salivary gland morphogenesis; branching morphogenesis of an epithelial tube; bronchiole morphogenesis; bud elongation involved in lung branching; bud outgrowth involved in lung branching; cell differentiation; cell population proliferation; cell-cell signaling; chemotaxis; determination of left/right symmetry; digestive tract development; embryonic camera-type eye development; embryonic digestive tract development; embryonic digestive tract morphogenesis; embryonic genitalia morphogenesis; embryonic pattern specification; endothelial cell proliferation; epidermis development; epidermis morphogenesis; epithelial cell differentiation; epithelial cell proliferation; epithelial cell proliferation involved in salivary gland morphogenesis; epithelial tube branching involved in lung morphogenesis; ERK1 and ERK2 cascade; establishment of mitotic spindle orientation; extrinsic apoptotic signaling pathway in absence of ligand; female genitalia morphogenesis; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; fibroblast proliferation; hair follicle morphogenesis; Harderian gland development; induction of positive chemotaxis; inner ear morphogenesis; keratinocyte proliferation; lacrimal gland development; limb bud formation; limb development; limb morphogenesis; lung alveolus development; lung development; lung epithelium development; lung morphogenesis; lung proximal/distal axis specification; lung saccule development; male genitalia morphogenesis; mammary gland bud formation; mammary gland specification; mesenchymal cell differentiation involved in lung development; mesenchymal-epithelial cell signaling involved in lung development; mesonephros development; metanephros development; metanephros morphogenesis; mitotic cell cycle; muscle cell fate commitment; negative regulation of epithelial cell differentiation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of stem cell proliferation; odontogenesis of dentin-containing tooth; organ growth; organ induction; otic vesicle formation; pancreas development; pituitary gland development; positive chemotaxis; positive regulation of ATP-dependent activity; positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA repair; positive regulation of DNA-templated transcription; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of hair follicle cell proliferation; positive regulation of keratinocyte migration; positive regulation of keratinocyte proliferation; positive regulation of lymphocyte proliferation; positive regulation of MAPK cascade; positive regulation of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of urothelial cell proliferation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of white fat cell proliferation; positive regulation of Wnt signaling pathway; prostatic bud formation; protein localization to cell surface; radial glial cell differentiation; regulation of activin receptor signaling pathway; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; regulation of cell migration; regulation of gene expression; regulation of saliva secretion; regulation of smoothened signaling pathway; respiratory system development; response to estradiol; response to lipopolysaccharide; response to organic cyclic compound; salivary gland development; salivary gland morphogenesis; secretion by lung epithelial cell involved in lung growth; semicircular canal fusion; semicircular canal morphogenesis; smooth muscle cell differentiation; somatic stem cell population maintenance; spleen development; stem cell proliferation; submandibular salivary gland formation; tear secretion; thymus development; thyroid gland development; tissue regeneration; type II pneumocyte differentiation; urothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; white fat cell differentiation; white fat cell proliferation; Wnt signaling pathway; wound healing","chemoattractant activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; protein binding; type 2 fibroblast growth factor receptor binding","cell surface; collagen-containing extracellular matrix; cytoplasm; extracellular region; extracellular space; nucleus; plasma membrane","Growth factor","fibroblast growth factor 10","http://www.ncbi.nlm.nih.gov/gene/?term=2255","2255","14165","25443","612454",null,"701584","O15520","O35565","P70492","A0A8I3MP09","F1SMG2","F6RWC6","GO:0009986; GO:0062023; GO:0005737; GO:0005576; GO:0005615; GO:0005634; GO:0005886","GO:0042056; GO:0005104; GO:0008083; GO:0008201; GO:0005515; GO:0005111","GO:0031532; GO:0001525; GO:0048645; GO:0009887; GO:0048514; GO:0001974; GO:0060667; GO:0060445; GO:0048754; GO:0060436; GO:0060449; GO:0060447; GO:0030154; GO:0008283; GO:0007267; GO:0006935; GO:0007368; GO:0048565; GO:0031076; GO:0048566; GO:0048557; GO:0030538; GO:0009880; GO:0001935; GO:0008544; GO:0048730; GO:0030855; GO:0050673; GO:0060664; GO:0060441; GO:0070371; GO:0000132; GO:0097192; GO:0048807; GO:0008543; GO:0060595; GO:0048144; GO:0031069; GO:0070384; GO:0050930; GO:0042472; GO:0043616; GO:0032808; GO:0060174; GO:0060173; GO:0035108; GO:0048286; GO:0030324; GO:0060428; GO:0060425; GO:0061115; GO:0060430; GO:0048808; GO:0060615; GO:0060594; GO:0060915; GO:0060496; GO:0001823; GO:0001656; GO:0003338; GO:0000278; GO:0042693; GO:0030857; GO:2001240; GO:2000647; GO:0042475; GO:0035265; GO:0001759; GO:0030916; GO:0031016; GO:0021983; GO:0050918; GO:0032781; GO:0090263; GO:0008284; GO:0045739; GO:0045893; GO:0001938; GO:0010634; GO:0050679; GO:0060054; GO:0070374; GO:0048146; GO:1900087; GO:0010628; GO:0071338; GO:0051549; GO:0010838; GO:0050671; GO:0043410; GO:0045931; GO:0045747; GO:0050731; GO:0001934; GO:0046579; GO:2000648; GO:0045944; GO:0050677; GO:0030949; GO:0070352; GO:0030177; GO:0060513; GO:0034394; GO:0060019; GO:0032925; GO:0060665; GO:0030334; GO:0010468; GO:0046877; GO:0008589; GO:0060541; GO:0032355; GO:0032496; GO:0014070; GO:0007431; GO:0007435; GO:0061033; GO:0060879; GO:0048752; GO:0051145; GO:0035019; GO:0048536; GO:0072089; GO:0060661; GO:0070075; GO:0048538; GO:0030878; GO:0042246; GO:0060510; GO:0050674; GO:0048010; GO:0050872; GO:0070343; GO:0016055; GO:0042060","PTHR11486:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3666|UniProtKB=O15520","P00021"]
["Fibronectin",null,"FN1","263","rb",null,1,1,1,2,"n/a","n/a","# 1249",".ANG., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .IMFR., .IMUR., .INT., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .SCLC., .ST., .TRASR.","Integrin signalling pathway","FIBRONECTIN","acute-phase response; angiogenesis; biological process involved in interaction with symbiont; blood coagulation, fibrin clot formation; calcium-independent cell-matrix adhesion; cell adhesion; cell-matrix adhesion; cell-substrate junction assembly; endodermal cell differentiation; heart development; integrin activation; integrin-mediated signaling pathway; negative regulation of monocyte activation; negative regulation of transforming growth factor beta production; nervous system development; neural crest cell migration involved in autonomic nervous system development; peptide cross-linking; platelet aggregation; positive regulation of axon extension; positive regulation of cell population proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of substrate-dependent cell migration, cell attachment to substrate; regulation of cell shape; regulation of ERK1 and ERK2 cascade; regulation of protein phosphorylation; response to wounding; substrate adhesion-dependent cell spreading; wound healing","chaperone binding; collagen binding; disordered domain specific binding; enzyme binding; extracellular matrix structural constituent; heparin binding; identical protein binding; integrin binding; peptidase activator activity; protease binding; protein binding; protein C-terminus binding; proteoglycan binding; signaling receptor binding","apical plasma membrane; basement membrane; blood microparticle; cellular anatomical entity; collagen-containing extracellular matrix; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; extracellular matrix; extracellular region; extracellular space; fibrinogen complex; plasma membrane; platelet alpha granule lumen","Adhesion","fibronectin 1","http://www.ncbi.nlm.nih.gov/gene/?term=2335","2335","14268","25661",null,null,null,"P02751","P11276","A0A096P6L8","A0A8I3PED8","A0A286ZY95","A0A5F7ZIJ6","GO:0016324; GO:0005604; GO:0072562; GO:0110165; GO:0062023; GO:0005788; GO:0005793; GO:0070062; GO:0031012; GO:0005576; GO:0005615; GO:0005577; GO:0005886; GO:0031093","GO:0051087; GO:0005518; GO:0097718; GO:0019899; GO:0005201; GO:0008201; GO:0042802; GO:0005178; GO:0016504; GO:0002020; GO:0005515; GO:0008022; GO:0043394; GO:0005102","GO:0006953; GO:0001525; GO:0051702; GO:0072378; GO:0007161; GO:0007155; GO:0007160; GO:0007044; GO:0035987; GO:0007507; GO:0033622; GO:0007229; GO:0150102; GO:0071635; GO:0007399; GO:1901166; GO:0018149; GO:0070527; GO:0045773; GO:0008284; GO:0048146; GO:0010628; GO:0014068; GO:1904237; GO:0008360; GO:0070372; GO:0001932; GO:0009611; GO:0034446; GO:0042060","PTHR46708:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3778|UniProtKB=P02751","P00034"]
["Filamin B",null,"FLNB","280","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2860",".CSP., .IIR., .IMUR., .INT., .MAPK., .OP., .OPA., .RTK., .ST.","Integrin signalling pathway","FILAMIN-B","actin cytoskeleton organization; cell differentiation; cellular response to type II interferon; cytoskeleton organization; epithelial cell morphogenesis; keratinocyte development; muscle organ development; signal transduction; skeletal muscle tissue development","actin binding; actin filament binding; cadherin binding; identical protein binding; protein binding; RNA binding","actin cytoskeleton; brush border; cell cortex; cytoplasm; cytoskeleton; cytosol; extracellular exosome; focal adhesion; intracellular non-membrane-bounded organelle; membrane; phagocytic vesicle; plasma membrane; stress fiber; Z disc",null,"filamin B","http://www.ncbi.nlm.nih.gov/gene/?term=2317","2317","286940","306204","484713",null,null,"O75369","Q80X90","A0A0G2JXT8","A0A8I3PEC3","A0A286ZPG4","A0A5F7ZEQ6","GO:0015629; GO:0005903; GO:0005938; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005925; GO:0043232; GO:0016020; GO:0045335; GO:0005886; GO:0001725; GO:0030018","GO:0003779; GO:0051015; GO:0045296; GO:0042802; GO:0005515; GO:0003723","GO:0030036; GO:0030154; GO:0071346; GO:0007010; GO:0003382; GO:0003334; GO:0007517; GO:0007165; GO:0007519","PTHR38537:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3755|UniProtKB=O75369","P00034"]
["FKBP12",null,"FKBP1A","12","ms",null,1,1,1,1,1,1,"# 2712",".CSP., .DEV., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .ST., .TCR., .TGFB., .UBI.","TGF-beta signaling pathway","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A-RELATED","amyloid fibril formation; calcium ion transmembrane transport; chaperone-mediated protein folding; 'de novo' protein folding; heart morphogenesis; heart trabecula formation; negative regulation of phosphoprotein phosphatase activity; negative regulation of release of sequestered calcium ion into cytosol; negative regulation of ryanodine-sensitive calcium-release channel activity; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein binding; positive regulation of protein ubiquitination; protein folding; protein maturation by protein folding; protein peptidyl-prolyl isomerization; protein refolding; regulation of activin receptor signaling pathway; regulation of amyloid precursor protein catabolic process; regulation of immune response; regulation of protein localization; regulation of ryanodine-sensitive calcium-release channel activity; SMAD protein complex assembly; supramolecular fiber organization; T cell activation; ventricular cardiac muscle tissue morphogenesis","activin binding; calcium channel inhibitor activity; FK506 binding; isomerase activity; macrolide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; SMAD binding; transforming growth factor beta receptor binding; transmembrane transporter binding; type I transforming growth factor beta receptor binding","cytoplasm; cytoplasmic side of membrane; cytosol; extrinsic component of organelle membrane; membrane; ryanodine receptor complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; terminal cisterna; Z disc","TGF-beta / Smad signaling","FKBP prolyl isomerase 1A","http://www.ncbi.nlm.nih.gov/gene/?term=2280","2280","14225",null,"100686033",null,null,"P62942","P26883","A0A8I6ANT3","A0A8I3Q1V5","A0A5G2QMX4","A0A5F8A664","GO:0005737; GO:0098562; GO:0005829; GO:0031312; GO:0016020; GO:1990425; GO:0016529; GO:0033017; GO:0014802; GO:0030018","GO:0048185; GO:0019855; GO:0005528; GO:0016853; GO:0005527; GO:0003755; GO:0005515; GO:0046332; GO:0005160; GO:0044325; GO:0034713","GO:1990000; GO:0070588; GO:0061077; GO:0006458; GO:0003007; GO:0060347; GO:0032515; GO:0051280; GO:0060315; GO:0030512; GO:0043123; GO:0032092; GO:0031398; GO:0006457; GO:0022417; GO:0000413; GO:0042026; GO:0032925; GO:1902991; GO:0050776; GO:0032880; GO:0060314; GO:0007183; GO:0097435; GO:0042110; GO:0055010","PTHR10516:SF301","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3711|UniProtKB=P62942","P00052"]
["FLOWER (C9orf7)",null,"CACFD1","18, 13","rb",null,2,8,"n/a","n/a","n/a","n/a","# 3077",null,null,"CALCIUM CHANNEL FLOWER HOMOLOG","biological_process; vesicle-mediated transport","molecular_function; protein binding","cellular_component; membrane",null,"calcium channel flower domain containing 1","http://www.ncbi.nlm.nih.gov/gene/?term=11094","11094","381356",null,null,null,null,"Q9UGQ2","Q8BG21","A0A8L2Q414",null,null,null,"GO:0005575; GO:0016020","GO:0003674; GO:0005515","GO:0008150; GO:0016192","PTHR13314:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1365|UniProtKB=Q9UGQ2"]
["FMRP",null,"FMR1","80","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1953",".CD., .CSP., .DDR., .DREP., .IMUR., .OP., .OPA., .OT., .ST., .TRASR., .VIR.",null,"SYNAPTIC FUNCTIONAL REGULATOR FMR1","cellular response to DNA damage stimulus; cellular response to virus; DNA repair; glutamate receptor signaling pathway; modulation by host of viral RNA genome replication; mRNA processing; mRNA transport; negative regulation of cytoplasmic translation; negative regulation of long-term synaptic depression; negative regulation of mRNA catabolic process; negative regulation of synaptic vesicle exocytosis; negative regulation of translation; negative regulation of translational initiation; negative regulation of voltage-gated calcium channel activity; nervous system development; positive regulation of dendritic spine development; positive regulation of filopodium assembly; positive regulation of intracellular transport of viral material; positive regulation of miRNA-mediated gene silencing; positive regulation of mRNA binding; positive regulation of proteasomal protein catabolic process; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of response to DNA damage stimulus; positive regulation of translation; regulation of alternative mRNA splicing, via spliceosome; regulation of dendritic spine development; regulation of filopodium assembly; regulation of miRNA-mediated gene silencing; regulation of mRNA stability; regulation of neuronal action potential; regulation of neurotransmitter secretion; regulation of translation; RNA splicing; RNA-mediated gene silencing","chromatin binding; DNA binding; dynein complex binding; G-quadruplex RNA binding; identical protein binding; methylated histone binding; microtubule binding; miRNA binding; molecular condensate scaffold activity; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA binding; nucleic acid binding; poly(G) binding; poly(U) RNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; ribosome binding; RNA binding; RNA stem-loop binding; RNA strand annealing activity; sequence-specific mRNA binding; siRNA binding; translation initiation factor binding; translation regulator activity; translation repressor activity; transmembrane transporter binding","axon; axon terminus; Cajal body; cell projection; chromocenter; chromosome; chromosome, centromeric region; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic stress granule; cytosol; dendrite; dendritic filopodium; dendritic spine; dendritic spine neck; extrinsic component of plasma membrane; filopodium tip; glial cell projection; growth cone; growth cone filopodium; intracellular non-membrane-bounded organelle; membrane; messenger ribonucleoprotein complex; mRNA cap binding complex; neuron projection; neuronal cell body; neuronal ribonucleoprotein granule; nucleolus; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane; polysome; postsynapse; postsynaptic density; postsynaptic membrane; presynapse; presynaptic membrane; ribonucleoprotein complex; SMN complex; synapse",null,"fragile X messenger ribonucleoprotein 1","http://www.ncbi.nlm.nih.gov/gene/?term=2332","2332",null,"24948","481070",null,null,"Q06787","D3Z6U8","Q80WE1","A0A8I3PAW4","A0A5G2R3I3","F7AGG4","GO:0030424; GO:0043679; GO:0015030; GO:0042995; GO:0010369; GO:0005694; GO:0000775; GO:0005737; GO:0036464; GO:0010494; GO:0005829; GO:0030425; GO:1902737; GO:0043197; GO:0044326; GO:0019897; GO:0032433; GO:0097386; GO:0030426; GO:1990812; GO:0043232; GO:0016020; GO:1990124; GO:0005845; GO:0043005; GO:0043025; GO:0071598; GO:0005730; GO:0005654; GO:0005634; GO:0043204; GO:0048471; GO:0005886; GO:0005844; GO:0098794; GO:0014069; GO:0045211; GO:0098793; GO:0042734; GO:1990904; GO:0032797; GO:0045202","GO:0003682; GO:0003677; GO:0070840; GO:0002151; GO:0042802; GO:0035064; GO:0008017; GO:0035198; GO:0140693; GO:0003730; GO:0048027; GO:0003729; GO:0003676; GO:0034046; GO:0008266; GO:0005515; GO:0046982; GO:0042803; GO:0043022; GO:0003723; GO:0035613; GO:0033592; GO:1990825; GO:0035197; GO:0031369; GO:0045182; GO:0030371; GO:0044325","GO:0006974; GO:0098586; GO:0006281; GO:0007215; GO:0044830; GO:0006397; GO:0051028; GO:2000766; GO:1900453; GO:1902373; GO:2000301; GO:0017148; GO:0045947; GO:1901386; GO:0007399; GO:0060999; GO:0051491; GO:1901254; GO:2000637; GO:1902416; GO:1901800; GO:0001934; GO:0002092; GO:2001022; GO:0045727; GO:0000381; GO:0060998; GO:0051489; GO:0060964; GO:0043488; GO:0098908; GO:0046928; GO:0006417; GO:0008380; GO:0031047","PTHR10603:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3775|UniProtKB=Q06787"]
["Folate binding protein",null,"FOLR1","30","rb",null,2,7,4,4,4,4,"# 1346",".CSP., .DEV., .DRR., .MIG., .OP., .OT., .TGFB., .WNT.",null,"FOLATE RECEPTOR ALPHA","anterior neural tube closure; axon regeneration; cardiac neural crest cell migration involved in outflow tract morphogenesis; cell adhesion; cellular response to folic acid; folic acid metabolic process; folic acid transport; fusion of sperm to egg plasma membrane involved in single fertilization; heart looping; neural crest cell migration involved in heart formation; pharyngeal arch artery morphogenesis; receptor-mediated endocytosis; regulation of canonical Wnt signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; renal absorption; response to axon injury; response to folic acid; sperm-egg recognition","folic acid binding; folic acid receptor activity; protein binding; signaling receptor activity","apical plasma membrane; basolateral plasma membrane; brush border; brush border membrane; cell surface; clathrin-coated vesicle; cytoplasmic vesicle; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; endosome; ER to Golgi transport vesicle membrane; external side of plasma membrane; extracellular exosome; extracellular region; Golgi membrane; membrane; nucleus; plasma membrane; transport vesicle","Transport","folate receptor alpha","http://www.ncbi.nlm.nih.gov/gene/?term=2348","2348","14275","171049",null,"396784","718388","P15328","P35846","G3V8M6",null,"A0A287BLX2","F7BP60","GO:0016324; GO:0016323; GO:0005903; GO:0031526; GO:0009986; GO:0030136; GO:0031410; GO:0005789; GO:0033116; GO:0005768; GO:0012507; GO:0009897; GO:0070062; GO:0005576; GO:0000139; GO:0016020; GO:0005634; GO:0005886; GO:0030133","GO:0005542; GO:0061714; GO:0005515; GO:0038023","GO:0061713; GO:0031103; GO:0003253; GO:0007155; GO:0071231; GO:0046655; GO:0015884; GO:0007342; GO:0001947; GO:0003147; GO:0061626; GO:0006898; GO:0060828; GO:0017015; GO:0070293; GO:0048678; GO:0051593; GO:0035036","PTHR10517:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3791|UniProtKB=P15328"]
["FoxA2/HNF3beta",null,"FOXA2","50","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2840",".OP., .OT., .PLAT., .TRASR.",null,"HEPATOCYTE NUCLEAR FACTOR 3-BETA","adult locomotory behavior; anatomical structure morphogenesis; cell differentiation; cell fate specification; chromatin organization; dopaminergic neuron differentiation; endocrine pancreas development; negative regulation of detection of glucose; negative regulation of DNA-binding transcription factor activity; negative regulation of epithelial to mesenchymal transition; negative regulation of glucokinase activity; negative regulation of transcription from RNA polymerase II promoter by glucose; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of DNA-templated transcription; positive regulation of embryonic development; positive regulation of gastrulation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter by glucose; primitive streak formation; regulation of blood coagulation; regulation of DNA-templated transcription; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of transcription by RNA polymerase II; response to interleukin-6","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nucleic acid binding; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","cell junction; chromatin; cytoplasm; nucleoplasm; nucleus",null,"forkhead box A2","http://www.ncbi.nlm.nih.gov/gene/?term=3170","3170","15376",null,null,"100513828","701771","Q9Y261","P35583","G3V7Q2","A0A8P0N7V3","A0A286ZU79","F7D2T8","GO:0030054; GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003677; GO:0003700; GO:0000981; GO:0003676; GO:0019904; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0008344; GO:0009653; GO:0030154; GO:0001708; GO:0006325; GO:0071542; GO:0031018; GO:2000971; GO:0043433; GO:0010719; GO:0033132; GO:0061987; GO:2000049; GO:0045893; GO:0040019; GO:2000543; GO:0045944; GO:0000432; GO:0090009; GO:0030193; GO:0006355; GO:0061178; GO:0006357; GO:0070741","PTHR11829:SF167","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5022|UniProtKB=Q9Y261"]
["FoxF1",null,"FOXF1","40","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2862",".CCP., .CP., .CSP., .DEV., .HHSP., .IMFR., .IMUR., .MIG., .OP., .OT., .TRASR.",null,"FORKHEAD BOX PROTEIN F1","animal organ morphogenesis; blood vessel development; cardiac left ventricle morphogenesis; cell-cell adhesion; cellular response to cytokine stimulus; cellular response to organic cyclic compound; detection of wounding; determination of left/right symmetry; digestive tract development; ductus arteriosus closure; embryonic digestive tract development; embryonic digestive tract morphogenesis; embryonic ectodermal digestive tract morphogenesis; embryonic foregut morphogenesis; endocardial cushion development; epithelial cell differentiation involved in mammary gland alveolus development; epithelial tube branching involved in lung morphogenesis; establishment of epithelial cell apical/basal polarity; extracellular matrix organization; heart development; in utero embryonic development; lateral mesodermal cell differentiation; lung alveolus development; lung development; lung lobe morphogenesis; lung morphogenesis; lung vasculature development; mesenchyme migration; mesoderm development; mesodermal cell differentiation; midgut development; morphogenesis of a branching structure; negative regulation of inflammatory response; negative regulation of mast cell degranulation; negative regulation of transcription by RNA polymerase II; pancreas development; positive regulation of cell migration; positive regulation of cell-substrate adhesion; positive regulation of DNA-templated transcription; positive regulation of mesenchymal cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; respiratory tube development; right lung morphogenesis; smooth muscle cell differentiation; smoothened signaling pathway; somitogenesis; trachea development; ureter development; vasculogenesis; venous blood vessel development","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding","chromatin; nucleus; transcription regulator complex",null,"forkhead box F1","http://www.ncbi.nlm.nih.gov/gene/?term=2294","2294","15227","687536",null,null,null,"Q12946","Q61080","M0R8R8","A0A8I3RTE0",null,null,"GO:0000785; GO:0005634; GO:0005667","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0000978; GO:0000977; GO:0043565; GO:0000976","GO:0009887; GO:0001568; GO:0003214; GO:0098609; GO:0071345; GO:0071407; GO:0014822; GO:0007368; GO:0048565; GO:0097070; GO:0048566; GO:0048557; GO:0048613; GO:0048617; GO:0003197; GO:0061030; GO:0060441; GO:0045198; GO:0030198; GO:0007507; GO:0001701; GO:0048371; GO:0048286; GO:0030324; GO:0060463; GO:0060425; GO:0060426; GO:0090131; GO:0007498; GO:0048333; GO:0007494; GO:0001763; GO:0050728; GO:0043305; GO:0000122; GO:0031016; GO:0030335; GO:0010811; GO:0045893; GO:0002053; GO:0045944; GO:0006355; GO:0006357; GO:0030323; GO:0060461; GO:0051145; GO:0007224; GO:0001756; GO:0060438; GO:0072189; GO:0001570; GO:0060841","PTHR46262:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3809|UniProtKB=Q12946"]
["FoxM1",null,"FOXM1","110","rb",null,7,1,1,1,4,4,"# 0949",".CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .MAPK., .OP., .OT., .OXS., .P53S., .RAS., .RTK., .SREME., .TRASR.",null,"FORKHEAD BOX PROTEIN M1","cell cycle; cellular response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; G2/M transition of mitotic cell cycle; negative regulation of DNA-templated transcription; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of Ras protein signal transduction; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein kinase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding","chromatin; nucleoplasm; nucleus","Transcription factor","forkhead box M1","http://www.ncbi.nlm.nih.gov/gene/?term=2305","2305",null,"58921",null,"100511565","708805","Q08050","A0A0N4SVY9","A0A8I6A7T5","A0A8I3PTJ8","A0A287AG20","F6T2H2","GO:0000785; GO:0005654; GO:0005634","GO:0003677; GO:0003700; GO:0000981; GO:0005515; GO:0019901; GO:0000977; GO:0043565","GO:0007049; GO:0006974; GO:0006978; GO:0006281; GO:0000086; GO:0045892; GO:0032873; GO:0000122; GO:0008284; GO:0045893; GO:2000781; GO:0045944; GO:0051726; GO:0042127; GO:0006355; GO:0046578; GO:2000377; GO:0006357","PTHR46878:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3818|UniProtKB=Q08050"]
["FoxM1",null,"FOXM1","110","rb",null,4,8,"n/a","n/a","n/a","n/a","# 1196",".CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .MAPK., .OP., .OT., .OXS., .P53S., .RAS., .RTK., .SREME., .TRASR.",null,"FORKHEAD BOX PROTEIN M1","cell cycle; cellular response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; G2/M transition of mitotic cell cycle; negative regulation of DNA-templated transcription; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of Ras protein signal transduction; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein kinase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding","chromatin; nucleoplasm; nucleus","Transcription factor","forkhead box M1","http://www.ncbi.nlm.nih.gov/gene/?term=2305","2305",null,"58921",null,"100511565","708805","Q08050","A0A0N4SVY9","A0A8I6A7T5","A0A8I3PTJ8","A0A287AG20","F6T2H2","GO:0000785; GO:0005654; GO:0005634","GO:0003677; GO:0003700; GO:0000981; GO:0005515; GO:0019901; GO:0000977; GO:0043565","GO:0007049; GO:0006974; GO:0006978; GO:0006281; GO:0000086; GO:0045892; GO:0032873; GO:0000122; GO:0008284; GO:0045893; GO:2000781; GO:0045944; GO:0051726; GO:0042127; GO:0006355; GO:0046578; GO:2000377; GO:0006357","PTHR46878:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3818|UniProtKB=Q08050"]
["FoxO1",null,"FOXO1","82","rb",null,4,4,"n/a","n/a","n/a","n/a","BG/MP # 043",".AMPK., .APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .FOXO., .INS., .MAPK., .OP., .OPA., .OT., .OXS., .PI3K., .PRC., .RTK., .SREME., .TRASR., .WNT.","CCKR signaling map; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O1","apoptotic process; autophagy; blood vessel development; canonical Wnt signaling pathway; cell differentiation; cellular glucose homeostasis; cellular response to cold; cellular response to DNA damage stimulus; cellular response to hyperoxia; cellular response to insulin stimulus; cellular response to nitric oxide; cellular response to oxidative stress; cellular response to starvation; energy homeostasis; fat cell differentiation; glucose homeostasis; insulin receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of DNA-templated transcription; negative regulation of fat cell differentiation; negative regulation of insulin secretion; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; neuronal stem cell population maintenance; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of gluconeogenesis; positive regulation of protein catabolic process; positive regulation of transcription by RNA polymerase II; protein acetylation; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of gluconeogenesis; regulation of neural precursor cell proliferation; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II; response to fatty acid; temperature homeostasis","beta-catenin binding; chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; promoter-specific chromatin binding; protein binding; protein phosphatase 2A binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus","Akt signaling","forkhead box O1","http://www.ncbi.nlm.nih.gov/gene/?term=2308","2308","56458","84482",null,null,"700030","Q12778","Q9R1E0","G3V7R4","A0A8I3PLD0","F1RME6","F6ZVZ0","GO:0000785; GO:0005737; GO:0005829; GO:0005739; GO:0005654; GO:0005634","GO:0008013; GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0003676; GO:1990841; GO:0005515; GO:0051721; GO:0000978; GO:0043565; GO:0031625","GO:0006915; GO:0006914; GO:0001568; GO:0060070; GO:0030154; GO:0001678; GO:0070417; GO:0006974; GO:0071455; GO:0032869; GO:0071732; GO:0034599; GO:0009267; GO:0097009; GO:0045444; GO:0042593; GO:0008286; GO:0043066; GO:0090090; GO:1903243; GO:0045892; GO:0045599; GO:0046676; GO:0032873; GO:0000122; GO:0097150; GO:0043065; GO:0010508; GO:0045893; GO:0045722; GO:0045732; GO:0045944; GO:0006473; GO:0042127; GO:0006355; GO:0006111; GO:2000177; GO:2000377; GO:0006357; GO:0070542; GO:0001659","PTHR45767:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3819|UniProtKB=Q12778","P06959; P00033; P00048"]
["FoxO1 - phospho","Ser256","FOXO1","82","rb",null,2.1,7,"n/a","n/a","n/a","n/a","BG/MP # 044",".AMPK., .APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .FOXO., .INS., .MAPK., .OP., .OPA., .OT., .OXS., .PI3K., .PRC., .RTK., .SREME., .TRASR., .WNT.","CCKR signaling map; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O1","apoptotic process; autophagy; blood vessel development; canonical Wnt signaling pathway; cell differentiation; cellular glucose homeostasis; cellular response to cold; cellular response to DNA damage stimulus; cellular response to hyperoxia; cellular response to insulin stimulus; cellular response to nitric oxide; cellular response to oxidative stress; cellular response to starvation; energy homeostasis; fat cell differentiation; glucose homeostasis; insulin receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of DNA-templated transcription; negative regulation of fat cell differentiation; negative regulation of insulin secretion; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; neuronal stem cell population maintenance; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of gluconeogenesis; positive regulation of protein catabolic process; positive regulation of transcription by RNA polymerase II; protein acetylation; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of gluconeogenesis; regulation of neural precursor cell proliferation; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II; response to fatty acid; temperature homeostasis","beta-catenin binding; chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; promoter-specific chromatin binding; protein binding; protein phosphatase 2A binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus","Akt signaling","forkhead box O1","http://www.ncbi.nlm.nih.gov/gene/?term=2308","2308","56458","84482",null,null,"700030","Q12778","Q9R1E0","G3V7R4","A0A8I3PLD0","F1RME6","F6ZVZ0","GO:0000785; GO:0005737; GO:0005829; GO:0005739; GO:0005654; GO:0005634","GO:0008013; GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0003676; GO:1990841; GO:0005515; GO:0051721; GO:0000978; GO:0043565; GO:0031625","GO:0006915; GO:0006914; GO:0001568; GO:0060070; GO:0030154; GO:0001678; GO:0070417; GO:0006974; GO:0071455; GO:0032869; GO:0071732; GO:0034599; GO:0009267; GO:0097009; GO:0045444; GO:0042593; GO:0008286; GO:0043066; GO:0090090; GO:1903243; GO:0045892; GO:0045599; GO:0046676; GO:0032873; GO:0000122; GO:0097150; GO:0043065; GO:0010508; GO:0045893; GO:0045722; GO:0045732; GO:0045944; GO:0006473; GO:0042127; GO:0006355; GO:0006111; GO:2000177; GO:2000377; GO:0006357; GO:0070542; GO:0001659","PTHR45767:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3819|UniProtKB=Q12778","P06959; P00033; P00048"]
["FoxO1 - phospho","Ser319","FOXO1","120","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2357",".AMPK., .APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .FOXO., .INS., .MAPK., .OP., .OPA., .OT., .OXS., .PI3K., .PRC., .RTK., .SREME., .TRASR., .WNT.","CCKR signaling map; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O1","apoptotic process; autophagy; blood vessel development; canonical Wnt signaling pathway; cell differentiation; cellular glucose homeostasis; cellular response to cold; cellular response to DNA damage stimulus; cellular response to hyperoxia; cellular response to insulin stimulus; cellular response to nitric oxide; cellular response to oxidative stress; cellular response to starvation; energy homeostasis; fat cell differentiation; glucose homeostasis; insulin receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of DNA-templated transcription; negative regulation of fat cell differentiation; negative regulation of insulin secretion; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; neuronal stem cell population maintenance; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of gluconeogenesis; positive regulation of protein catabolic process; positive regulation of transcription by RNA polymerase II; protein acetylation; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of gluconeogenesis; regulation of neural precursor cell proliferation; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II; response to fatty acid; temperature homeostasis","beta-catenin binding; chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; promoter-specific chromatin binding; protein binding; protein phosphatase 2A binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus",null,"forkhead box O1","http://www.ncbi.nlm.nih.gov/gene/?term=2308","2308","56458","84482",null,null,"700030","Q12778","Q9R1E0","G3V7R4","A0A8I3PLD0","F1RME6","F6ZVZ0","GO:0000785; GO:0005737; GO:0005829; GO:0005739; GO:0005654; GO:0005634","GO:0008013; GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0003676; GO:1990841; GO:0005515; GO:0051721; GO:0000978; GO:0043565; GO:0031625","GO:0006915; GO:0006914; GO:0001568; GO:0060070; GO:0030154; GO:0001678; GO:0070417; GO:0006974; GO:0071455; GO:0032869; GO:0071732; GO:0034599; GO:0009267; GO:0097009; GO:0045444; GO:0042593; GO:0008286; GO:0043066; GO:0090090; GO:1903243; GO:0045892; GO:0045599; GO:0046676; GO:0032873; GO:0000122; GO:0097150; GO:0043065; GO:0010508; GO:0045893; GO:0045722; GO:0045732; GO:0045944; GO:0006473; GO:0042127; GO:0006355; GO:0006111; GO:2000177; GO:2000377; GO:0006357; GO:0070542; GO:0001659","PTHR45767:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3819|UniProtKB=Q12778","P06959; P00033; P00048"]
["FoxO1/O3a/O4 - phospho","Thr24/Thr32/Thr28","FOXO1, FOXO3, FOXO4","95, 82-78, 65","rb",null,2,2,8,8,8,8,"# 2314",".AMPK., .ANG., .APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MAPK., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .PRC., .RAS., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR., .WNT.","CCKR signaling map; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway; Interleukin signaling pathway","FORKHEAD BOX PROTEIN O1; FORKHEAD BOX PROTEIN O3-RELATED; FORKHEAD BOX PROTEIN O4","apoptotic process; autophagy; blood vessel development; canonical Wnt signaling pathway; cell differentiation; cellular glucose homeostasis; cellular response to cold; cellular response to DNA damage stimulus; cellular response to hyperoxia; cellular response to insulin stimulus; cellular response to nitric oxide; cellular response to oxidative stress; cellular response to starvation; energy homeostasis; fat cell differentiation; glucose homeostasis; insulin receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of DNA-templated transcription; negative regulation of fat cell differentiation; negative regulation of insulin secretion; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; neuronal stem cell population maintenance; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of gluconeogenesis; positive regulation of protein catabolic process; positive regulation of transcription by RNA polymerase II; protein acetylation; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of gluconeogenesis; regulation of neural precursor cell proliferation; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II; response to fatty acid; temperature homeostasis; cellular response to glucose starvation; mitochondrial transcription; negative regulation of cell migration; positive regulation of erythrocyte differentiation; positive regulation of miRNA transcription; positive regulation of muscle atrophy; positive regulation of neuron apoptotic process; positive regulation of regulatory T cell differentiation; regulation of translation; response to starvation; tumor necrosis factor-mediated signaling pathway; aging; cell cycle; mitotic G2 DNA damage checkpoint signaling; muscle organ development; negative regulation of angiogenesis; negative regulation of cell population proliferation; negative regulation of G0 to G1 transition; negative regulation of smooth muscle cell differentiation; positive regulation of smooth muscle cell migration; response to nutrient levels; response to water-immersion restraint stress; stem cell differentiation","beta-catenin binding; chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; promoter-specific chromatin binding; protein binding; protein phosphatase 2A binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; ubiquitin protein ligase binding; mitochondrial transcription factor activity; protein kinase binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; DNA-binding transcription factor binding; enzyme binding; identical protein binding","chromatin; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; membrane; mitochondrial matrix; mitochondrial outer membrane; protein-containing complex; RNA polymerase II transcription repressor complex; nuclear speck","Akt signaling","forkhead box O1; forkhead box O3; forkhead box O4","http://www.ncbi.nlm.nih.gov/gene/?term=2308, http://www.ncbi.nlm.nih.gov/gene/?term=2309, http://www.ncbi.nlm.nih.gov/gene/?term=4303","2308, 2309, 4303","56458, 56484, 54601","84482, 294515, NA",null,null,"700030, NA, 698055","Q12778, O43524, P98177","Q9R1E0, Q9WVH4, Q9WVH3","G3V7R4, D3ZBQ1, A0A096MJF0","A0A8I3PLD0, A0A8I3N1R5, A0A8I3NW63","F1RME6, F1RT23, A0A5G2QVH2","F6ZVZ0, A0A5F8A6I3, G7NRU9","GO:0000785; GO:0005737; GO:0005829; GO:0005739; GO:0005654; GO:0005634; GO:0016020; GO:0005759; GO:0005741; GO:0032991; GO:0090571; GO:0016607","GO:0008013; GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0003676; GO:1990841; GO:0005515; GO:0051721; GO:0000978; GO:0043565; GO:0031625; GO:0034246; GO:0019901; GO:1990837; GO:0000976; GO:0140297; GO:0019899; GO:0042802","GO:0006915; GO:0006914; GO:0001568; GO:0060070; GO:0030154; GO:0001678; GO:0070417; GO:0006974; GO:0071455; GO:0032869; GO:0071732; GO:0034599; GO:0009267; GO:0097009; GO:0045444; GO:0042593; GO:0008286; GO:0043066; GO:0090090; GO:1903243; GO:0045892; GO:0045599; GO:0046676; GO:0032873; GO:0000122; GO:0097150; GO:0043065; GO:0010508; GO:0045893; GO:0045722; GO:0045732; GO:0045944; GO:0006473; GO:0042127; GO:0006355; GO:0006111; GO:2000177; GO:2000377; GO:0006357; GO:0070542; GO:0001659; GO:0042149; GO:0006390; GO:0030336; GO:0045648; GO:1902895; GO:0014737; GO:0043525; GO:0045591; GO:0006417; GO:0042594; GO:0033209; GO:0007568; GO:0007049; GO:0007095; GO:0007517; GO:0016525; GO:0008285; GO:0070317; GO:0051151; GO:0014911; GO:0031667; GO:1990785; GO:0048863","PTHR45767:SF1; PTHR45767:SF4; PTHR45767:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3819|UniProtKB=Q12778; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3821|UniProtKB=O43524; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7139|UniProtKB=P98177","P06959; P00033; P00048; P00036"]
["FoxO3a",null,"FOXO3","97-82","rb",null,1,1,"n/a","n/a","n/a","n/a","# 3123",".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O3-RELATED","apoptotic process; cellular response to glucose starvation; cellular response to oxidative stress; mitochondrial transcription; negative regulation of cell migration; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of miRNA transcription; positive regulation of muscle atrophy; positive regulation of neuron apoptotic process; positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of translation; response to fatty acid; response to starvation; tumor necrosis factor-mediated signaling pathway","beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; mitochondrial transcription factor activity; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex",null,"forkhead box O3","http://www.ncbi.nlm.nih.gov/gene/?term=2309","2309","56484","294515",null,null,null,"O43524","Q9WVH4","D3ZBQ1","A0A8I3N1R5","F1RT23","A0A5F8A6I3","GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0005759; GO:0005741; GO:0005739; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0034246; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0006915; GO:0042149; GO:0034599; GO:0006390; GO:0030336; GO:0000122; GO:0043065; GO:0010508; GO:0045893; GO:0045648; GO:1902895; GO:0014737; GO:0043525; GO:0045591; GO:0045944; GO:0006355; GO:0006357; GO:0006417; GO:0070542; GO:0042594; GO:0033209","PTHR45767:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3821|UniProtKB=O43524","P06959; P00036; P00033; P00048"]
["FoxO3a - phospho","Ser253","FOXO3","97","rb",null,4,6,"n/a","n/a","n/a","n/a","# 2361",".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O3-RELATED","apoptotic process; cellular response to glucose starvation; cellular response to oxidative stress; mitochondrial transcription; negative regulation of cell migration; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of miRNA transcription; positive regulation of muscle atrophy; positive regulation of neuron apoptotic process; positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of translation; response to fatty acid; response to starvation; tumor necrosis factor-mediated signaling pathway","beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; mitochondrial transcription factor activity; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex",null,"forkhead box O3","http://www.ncbi.nlm.nih.gov/gene/?term=2309","2309","56484","294515",null,null,null,"O43524","Q9WVH4","D3ZBQ1","A0A8I3N1R5","F1RT23","A0A5F8A6I3","GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0005759; GO:0005741; GO:0005739; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0034246; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0006915; GO:0042149; GO:0034599; GO:0006390; GO:0030336; GO:0000122; GO:0043065; GO:0010508; GO:0045893; GO:0045648; GO:1902895; GO:0014737; GO:0043525; GO:0045591; GO:0045944; GO:0006355; GO:0006357; GO:0006417; GO:0070542; GO:0042594; GO:0033209","PTHR45767:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3821|UniProtKB=O43524","P06959; P00036; P00033; P00048"]
["FoxO3a - phospho","Ser294","FOXO3","97-82","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2359",".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O3-RELATED","apoptotic process; cellular response to glucose starvation; cellular response to oxidative stress; mitochondrial transcription; negative regulation of cell migration; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of miRNA transcription; positive regulation of muscle atrophy; positive regulation of neuron apoptotic process; positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of translation; response to fatty acid; response to starvation; tumor necrosis factor-mediated signaling pathway","beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; mitochondrial transcription factor activity; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex",null,"forkhead box O3","http://www.ncbi.nlm.nih.gov/gene/?term=2309","2309","56484","294515",null,null,null,"O43524","Q9WVH4","D3ZBQ1","A0A8I3N1R5","F1RT23","A0A5F8A6I3","GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0005759; GO:0005741; GO:0005739; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0034246; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0006915; GO:0042149; GO:0034599; GO:0006390; GO:0030336; GO:0000122; GO:0043065; GO:0010508; GO:0045893; GO:0045648; GO:1902895; GO:0014737; GO:0043525; GO:0045591; GO:0045944; GO:0006355; GO:0006357; GO:0006417; GO:0070542; GO:0042594; GO:0033209","PTHR45767:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3821|UniProtKB=O43524","P06959; P00036; P00033; P00048"]
["FoxO3a - phospho","Ser318/321","FOXO3","97","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2360",".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O3-RELATED","apoptotic process; cellular response to glucose starvation; cellular response to oxidative stress; mitochondrial transcription; negative regulation of cell migration; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of miRNA transcription; positive regulation of muscle atrophy; positive regulation of neuron apoptotic process; positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of translation; response to fatty acid; response to starvation; tumor necrosis factor-mediated signaling pathway","beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; mitochondrial transcription factor activity; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex",null,"forkhead box O3","http://www.ncbi.nlm.nih.gov/gene/?term=2309","2309","56484","294515",null,null,null,"O43524","Q9WVH4","D3ZBQ1","A0A8I3N1R5","F1RT23","A0A5F8A6I3","GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0005759; GO:0005741; GO:0005739; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0034246; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0006915; GO:0042149; GO:0034599; GO:0006390; GO:0030336; GO:0000122; GO:0043065; GO:0010508; GO:0045893; GO:0045648; GO:1902895; GO:0014737; GO:0043525; GO:0045591; GO:0045944; GO:0006355; GO:0006357; GO:0006417; GO:0070542; GO:0042594; GO:0033209","PTHR45767:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3821|UniProtKB=O43524","P06959; P00036; P00033; P00048"]
["FoxO3a - phospho","Ser413","FOXO3","97-82","rb",null,1.1000000000000001,4,4,4,4,4,"# 2137",".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O3-RELATED","apoptotic process; cellular response to glucose starvation; cellular response to oxidative stress; mitochondrial transcription; negative regulation of cell migration; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of miRNA transcription; positive regulation of muscle atrophy; positive regulation of neuron apoptotic process; positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of translation; response to fatty acid; response to starvation; tumor necrosis factor-mediated signaling pathway","beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; mitochondrial transcription factor activity; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex","Akt signaling","forkhead box O3","http://www.ncbi.nlm.nih.gov/gene/?term=2309","2309","56484","294515",null,null,null,"O43524","Q9WVH4","D3ZBQ1","A0A8I3N1R5","F1RT23","A0A5F8A6I3","GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0005759; GO:0005741; GO:0005739; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0034246; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0006915; GO:0042149; GO:0034599; GO:0006390; GO:0030336; GO:0000122; GO:0043065; GO:0010508; GO:0045893; GO:0045648; GO:1902895; GO:0014737; GO:0043525; GO:0045591; GO:0045944; GO:0006355; GO:0006357; GO:0006417; GO:0070542; GO:0042594; GO:0033209","PTHR45767:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3821|UniProtKB=O43524","P06959; P00036; P00033; P00048"]
["FoxO3a - phospho","Ser425","FOXO3","97-82","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2363",".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O3-RELATED","apoptotic process; cellular response to glucose starvation; cellular response to oxidative stress; mitochondrial transcription; negative regulation of cell migration; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of miRNA transcription; positive regulation of muscle atrophy; positive regulation of neuron apoptotic process; positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of translation; response to fatty acid; response to starvation; tumor necrosis factor-mediated signaling pathway","beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; mitochondrial transcription factor activity; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex",null,"forkhead box O3","http://www.ncbi.nlm.nih.gov/gene/?term=2309","2309","56484","294515",null,null,null,"O43524","Q9WVH4","D3ZBQ1","A0A8I3N1R5","F1RT23","A0A5F8A6I3","GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0005759; GO:0005741; GO:0005739; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0034246; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0006915; GO:0042149; GO:0034599; GO:0006390; GO:0030336; GO:0000122; GO:0043065; GO:0010508; GO:0045893; GO:0045648; GO:1902895; GO:0014737; GO:0043525; GO:0045591; GO:0045944; GO:0006355; GO:0006357; GO:0006417; GO:0070542; GO:0042594; GO:0033209","PTHR45767:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3821|UniProtKB=O43524","P06959; P00036; P00033; P00048"]
["FoxO3a - phospho","Ser7","FOXO3","97-82","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2362",".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; PI3 kinase pathway","FORKHEAD BOX PROTEIN O3-RELATED","apoptotic process; cellular response to glucose starvation; cellular response to oxidative stress; mitochondrial transcription; negative regulation of cell migration; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of miRNA transcription; positive regulation of muscle atrophy; positive regulation of neuron apoptotic process; positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of translation; response to fatty acid; response to starvation; tumor necrosis factor-mediated signaling pathway","beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; mitochondrial transcription factor activity; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex",null,"forkhead box O3","http://www.ncbi.nlm.nih.gov/gene/?term=2309","2309","56484","294515",null,null,null,"O43524","Q9WVH4","D3ZBQ1","A0A8I3N1R5","F1RT23","A0A5F8A6I3","GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0005759; GO:0005741; GO:0005739; GO:0005654; GO:0005634; GO:0032991; GO:0090571","GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0034246; GO:0005515; GO:0019901; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0006915; GO:0042149; GO:0034599; GO:0006390; GO:0030336; GO:0000122; GO:0043065; GO:0010508; GO:0045893; GO:0045648; GO:1902895; GO:0014737; GO:0043525; GO:0045591; GO:0045944; GO:0006355; GO:0006357; GO:0006417; GO:0070542; GO:0042594; GO:0033209","PTHR45767:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3821|UniProtKB=O43524","P06959; P00036; P00033; P00048"]
["FOXP3",null,"FOXP3","47","rb",null,2,2,"n/a","n/a","n/a","n/a","# 3209",".BCR., .CCP., .CP., .CSP., .IMFR., .IMU., .IMUF., .IMUR., .OP., .OT., .TCD., .TCR., .TMAT., .TRASR., .VIR.",null,"FORKHEAD BOX PROTEIN P3","alpha-beta T cell proliferation; B cell homeostasis; CD4-positive, alpha-beta T cell differentiation; CD4-positive, alpha-beta T cell proliferation; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; chromatin remodeling; DNA-templated transcription; establishment of endothelial blood-brain barrier; gene expression; histone acetylation; immature T cell proliferation in thymus; inflammatory response; isotype switching to IgE isotypes; lymphocyte proliferation; myeloid cell homeostasis; negative regulation of activated T cell proliferation; negative regulation of alpha-beta T cell proliferation; negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of cell population proliferation; negative regulation of chronic inflammatory response; negative regulation of CREB transcription factor activity; negative regulation of cytokine production; negative regulation of defense response to virus; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of histone acetylation; negative regulation of histone deacetylation; negative regulation of immune response; negative regulation of inflammatory response; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; negative regulation of interleukin-6 production; negative regulation of isotype switching to IgE isotypes; negative regulation of lymphocyte proliferation; negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell cytokine production; negative regulation of T cell proliferation; negative regulation of T-helper 17 cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; negative regulation of type II interferon production; positive regulation of CD4-positive, alpha-beta T cell differentiation; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of histone acetylation; positive regulation of immature T cell proliferation in thymus; positive regulation of interleukin-4 production; positive regulation of peripheral T cell tolerance induction; positive regulation of regulatory T cell differentiation; positive regulation of T cell anergy; positive regulation of T cell tolerance induction; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta1 production; regulation of DNA-templated transcription; regulation of immunoglobulin production; regulation of isotype switching to IgG isotypes; regulation of T cell anergy; regulation of transcription by RNA polymerase II; regulatory T cell differentiation; response to lipopolysaccharide; response to radiation; response to rapamycin; response to virus; T cell activation; T cell anergy; T cell homeostasis; T cell mediated immunity; T cell proliferation; T cell receptor signaling pathway; T cell tolerance induction; tolerance induction; tolerance induction to self antigen; transcription by RNA polymerase II; transforming growth factor beta1 production","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone acetyltransferase binding; histone deacetylase binding; identical protein binding; metal ion binding; NFAT protein binding; NF-kappaB binding; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription corepressor activity","chromatin; cytoplasm; nucleoplasm; nucleus; protein-containing complex",null,"forkhead box P3","http://www.ncbi.nlm.nih.gov/gene/?term=50943","50943","20371",null,null,null,"574303","Q9BZS1","Q99JB6","A0A8I6G4G9","A0A8I3PRA7","A0A287B120","F7CMV8","GO:0000785; GO:0005737; GO:0005654; GO:0005634; GO:0032991","GO:0003677; GO:0003700; GO:0000981; GO:0001227; GO:0035035; GO:0042826; GO:0042802; GO:0046872; GO:0051525; GO:0051059; GO:0005515; GO:0042803; GO:0000978; GO:0043565; GO:1990837; GO:0003714","GO:0046633; GO:0001782; GO:0043367; GO:0035739; GO:0002361; GO:0002362; GO:0006338; GO:0006351; GO:0014045; GO:0010467; GO:0016573; GO:0033080; GO:0006954; GO:0048289; GO:0046651; GO:0002262; GO:0046007; GO:0046642; GO:2000562; GO:0008285; GO:0002677; GO:0032792; GO:0001818; GO:0050687; GO:0043433; GO:0045892; GO:0010629; GO:0035067; GO:0031064; GO:0050777; GO:0050728; GO:0032693; GO:0032700; GO:0032703; GO:0032713; GO:0032714; GO:0032715; GO:0048294; GO:0050672; GO:0032088; GO:0002725; GO:0042130; GO:2000320; GO:0000122; GO:0032720; GO:0032689; GO:0043372; GO:0032831; GO:0045893; GO:0010628; GO:0035066; GO:0033092; GO:0032753; GO:0002851; GO:0045591; GO:0002669; GO:0002666; GO:0045944; GO:0032914; GO:0006355; GO:0002637; GO:0048302; GO:0002667; GO:0006357; GO:0045066; GO:0032496; GO:0009314; GO:1901355; GO:0009615; GO:0042110; GO:0002870; GO:0043029; GO:0002456; GO:0042098; GO:0050852; GO:0002517; GO:0002507; GO:0002513; GO:0006366; GO:0032905","PTHR45796:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6106|UniProtKB=Q9BZS1"]
["FRA1",null,"FOSL1","40","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1036",".APO., .cAMP., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DRR., .GPCR., .IMUR., .OP., .OT., .OXS., .SREME., .TGFB., .TRASR., .VIR., .WNT.","TGF-beta signaling pathway","FOS-RELATED ANTIGEN 1","cellular defense response; cellular response to extracellular stimulus; chemotaxis; female pregnancy; in utero embryonic development; integrated stress response signaling; learning; negative regulation of cell population proliferation; placenta blood vessel development; positive regulation of apoptotic process; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription initiation; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to cAMP; response to corticosterone; response to cytokine; response to gravity; response to hydrogen peroxide; response to mechanical stimulus; response to organic cyclic compound; response to progesterone; response to virus; response to xenobiotic stimulus; vitellogenesis","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; cytosol; intracellular membrane-bounded organelle; neuron projection; nucleoplasm; nucleus; presynaptic membrane; RNA polymerase II transcription regulator complex","MAPK signaling","FOS like 1, AP-1 transcription factor subunit","http://www.ncbi.nlm.nih.gov/gene/?term=8061","8061","14283","25445","483724","100525205","106993191","P15407","P48755","P10158","A0A8I3P2C8","A0A287BK33","A0A1D5QYS2","GO:0000785; GO:0005829; GO:0043231; GO:0043005; GO:0005654; GO:0005634; GO:0042734; GO:0090575","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0000978; GO:0000977; GO:1990837","GO:0006968; GO:0031668; GO:0006935; GO:0007565; GO:0001701; GO:0140467; GO:0007612; GO:0008285; GO:0060674; GO:0043065; GO:0045787; GO:0008284; GO:0051091; GO:2000144; GO:1902895; GO:0045944; GO:0006355; GO:0006357; GO:0051591; GO:0051412; GO:0034097; GO:0009629; GO:0042542; GO:0009612; GO:0014070; GO:0032570; GO:0009615; GO:0009410; GO:0007296","PTHR23351:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13718|UniProtKB=P15407","P00052"]
["FRA1",null,"FOSL1","40-38","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2342",".APO., .cAMP., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DRAS., .DRR., .GPCR., .IMUR., .OP., .OT., .OXS., .SREME., .TGFB., .TRASR., .VIR., .WNT.","TGF-beta signaling pathway","FOS-RELATED ANTIGEN 1","cellular defense response; cellular response to extracellular stimulus; chemotaxis; female pregnancy; in utero embryonic development; integrated stress response signaling; learning; negative regulation of cell population proliferation; placenta blood vessel development; positive regulation of apoptotic process; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription initiation; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to cAMP; response to corticosterone; response to cytokine; response to gravity; response to hydrogen peroxide; response to mechanical stimulus; response to organic cyclic compound; response to progesterone; response to virus; response to xenobiotic stimulus; vitellogenesis","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; cytosol; intracellular membrane-bounded organelle; neuron projection; nucleoplasm; nucleus; presynaptic membrane; RNA polymerase II transcription regulator complex","MAPK signaling","FOS like 1, AP-1 transcription factor subunit","http://www.ncbi.nlm.nih.gov/gene/?term=8061","8061","14283","25445","483724","100525205","106993191","P15407","P48755","P10158","A0A8I3P2C8","A0A287BK33","A0A1D5QYS2","GO:0000785; GO:0005829; GO:0043231; GO:0043005; GO:0005654; GO:0005634; GO:0042734; GO:0090575","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0000978; GO:0000977; GO:1990837","GO:0006968; GO:0031668; GO:0006935; GO:0007565; GO:0001701; GO:0140467; GO:0007612; GO:0008285; GO:0060674; GO:0043065; GO:0045787; GO:0008284; GO:0051091; GO:2000144; GO:1902895; GO:0045944; GO:0006355; GO:0006357; GO:0051591; GO:0051412; GO:0034097; GO:0009629; GO:0042542; GO:0009612; GO:0014070; GO:0032570; GO:0009615; GO:0009410; GO:0007296","PTHR23351:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13718|UniProtKB=P15407","P00052"]
["FRA1 - phospho","Ser265","FOSL1","40","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1035",".APO., .cAMP., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DRAS., .DRR., .GPCR., .IMUR., .OP., .OT., .OXS., .SREME., .TGFB., .TRASR., .VIR., .WNT.","TGF-beta signaling pathway","FOS-RELATED ANTIGEN 1","cellular defense response; cellular response to extracellular stimulus; chemotaxis; female pregnancy; in utero embryonic development; integrated stress response signaling; learning; negative regulation of cell population proliferation; placenta blood vessel development; positive regulation of apoptotic process; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription initiation; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to cAMP; response to corticosterone; response to cytokine; response to gravity; response to hydrogen peroxide; response to mechanical stimulus; response to organic cyclic compound; response to progesterone; response to virus; response to xenobiotic stimulus; vitellogenesis","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; cytosol; intracellular membrane-bounded organelle; neuron projection; nucleoplasm; nucleus; presynaptic membrane; RNA polymerase II transcription regulator complex","MAPK signaling","FOS like 1, AP-1 transcription factor subunit","http://www.ncbi.nlm.nih.gov/gene/?term=8061","8061","14283","25445","483724","100525205","106993191","P15407","P48755","P10158","A0A8I3P2C8","A0A287BK33","A0A1D5QYS2","GO:0000785; GO:0005829; GO:0043231; GO:0043005; GO:0005654; GO:0005634; GO:0042734; GO:0090575","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0000978; GO:0000977; GO:1990837","GO:0006968; GO:0031668; GO:0006935; GO:0007565; GO:0001701; GO:0140467; GO:0007612; GO:0008285; GO:0060674; GO:0043065; GO:0045787; GO:0008284; GO:0051091; GO:2000144; GO:1902895; GO:0045944; GO:0006355; GO:0006357; GO:0051591; GO:0051412; GO:0034097; GO:0009629; GO:0042542; GO:0009612; GO:0014070; GO:0032570; GO:0009615; GO:0009410; GO:0007296","PTHR23351:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13718|UniProtKB=P15407","P00052"]
["FRA2",null,"FOSL2","35","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1405",".CCP., .CP., .OP., .OT., .TRASR.",null,"FOS-RELATED ANTIGEN 2","cell death; keratinocyte development; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding","chromatin; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Transcription regulation","FOS like 2, AP-1 transcription factor subunit","http://www.ncbi.nlm.nih.gov/gene/?term=2355","2355","14284",null,null,null,"703068","P15408","P47930",null,null,null,"F7BA58","GO:0000785; GO:0005654; GO:0005634; GO:0090575","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0000978; GO:0000977","GO:0008219; GO:0003334; GO:0045893; GO:0048146; GO:0045944; GO:0006355; GO:0006357","PTHR23351:SF25","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3798|UniProtKB=P15408"]
["FRS2-alpha - phospho","Tyr196","FRS2","85","rb",null,4,4,"n/a","n/a","n/a","n/a","# 3060",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .FGFR., .GPCR., .GPROT., .MAPK., .OP., .OPA., .RTK., .ST.","FGF signaling pathway; Angiogenesis","FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2","anterior/posterior axis specification, embryo; cellular response to fibroblast growth factor stimulus; fibroblast growth factor receptor signaling pathway; forebrain development; G protein-coupled receptor signaling pathway; gastrulation with mouth forming second; lens development in camera-type eye; lens fiber cell development; lens placode formation involved in camera-type eye formation; negative regulation of cardiac muscle cell differentiation; neuroblast proliferation; organ induction; positive regulation of MAPK cascade; positive regulation of vascular associated smooth muscle cell proliferation; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; regulation of apoptotic process; regulation of epithelial cell proliferation; regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine kinase signaling pathway; transmembrane receptor protein tyrosine phosphatase signaling pathway; ventricular septum development","fibroblast growth factor receptor binding; neurotrophin TRKA receptor binding; phosphatase activator activity; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity","adherens junction; cell-cell junction; cytoplasm; cytosol; endomembrane system; membrane; plasma membrane",null,"fibroblast growth factor receptor substrate 2","http://www.ncbi.nlm.nih.gov/gene/?term=10818","10818","327826",null,"474444",null,null,"Q8WU20","Q8C180","A0A8I6A9E6","A0A8I3P4L9","A0A287ATQ6","A0A5F7Z9X2","GO:0005912; GO:0005911; GO:0005737; GO:0005829; GO:0012505; GO:0016020; GO:0005886","GO:0005104; GO:0005168; GO:0019211; GO:0005515; GO:0005068","GO:0008595; GO:0044344; GO:0008543; GO:0030900; GO:0007186; GO:0001702; GO:0002088; GO:0070307; GO:0046619; GO:2000726; GO:0007405; GO:0001759; GO:0043410; GO:1904707; GO:0060527; GO:0042981; GO:0050678; GO:0070372; GO:0007169; GO:0007185; GO:0003281","PTHR21258:SF40","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16971|UniProtKB=Q8WU20","P00021; P00005"]
["FRS2-alpha - phospho","Tyr436","FRS2","85-80","rb",null,4,4,"n/a","n/a","n/a","n/a","# 3059",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .FGFR., .GPCR., .GPROT., .MAPK., .OP., .OPA., .RTK., .ST.","FGF signaling pathway; Angiogenesis","FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2","anterior/posterior axis specification, embryo; cellular response to fibroblast growth factor stimulus; fibroblast growth factor receptor signaling pathway; forebrain development; G protein-coupled receptor signaling pathway; gastrulation with mouth forming second; lens development in camera-type eye; lens fiber cell development; lens placode formation involved in camera-type eye formation; negative regulation of cardiac muscle cell differentiation; neuroblast proliferation; organ induction; positive regulation of MAPK cascade; positive regulation of vascular associated smooth muscle cell proliferation; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; regulation of apoptotic process; regulation of epithelial cell proliferation; regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine kinase signaling pathway; transmembrane receptor protein tyrosine phosphatase signaling pathway; ventricular septum development","fibroblast growth factor receptor binding; neurotrophin TRKA receptor binding; phosphatase activator activity; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity","adherens junction; cell-cell junction; cytoplasm; cytosol; endomembrane system; membrane; plasma membrane",null,"fibroblast growth factor receptor substrate 2","http://www.ncbi.nlm.nih.gov/gene/?term=10818","10818","327826",null,"474444",null,null,"Q8WU20","Q8C180","A0A8I6A9E6","A0A8I3P4L9","A0A287ATQ6","A0A5F7Z9X2","GO:0005912; GO:0005911; GO:0005737; GO:0005829; GO:0012505; GO:0016020; GO:0005886","GO:0005104; GO:0005168; GO:0019211; GO:0005515; GO:0005068","GO:0008595; GO:0044344; GO:0008543; GO:0030900; GO:0007186; GO:0001702; GO:0002088; GO:0070307; GO:0046619; GO:2000726; GO:0007405; GO:0001759; GO:0043410; GO:1904707; GO:0060527; GO:0042981; GO:0050678; GO:0070372; GO:0007169; GO:0007185; GO:0003281","PTHR21258:SF40","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16971|UniProtKB=Q8WU20","P00021; P00005"]
["FTCD",null,"FTCD","59","rb",null,2,1,1,6,1,2,"# 1128",null,null,"FORMIMIDOYLTRANSFERASE-CYCLODEAMINASE","cytoskeleton organization; folic acid-containing compound metabolic process; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate; histidine metabolic process; metabolic process","catalytic activity; folic acid binding; formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; lyase activity; microtubule binding; protein binding; transferase activity","centriole; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; Golgi apparatus; Golgi membrane; plasma membrane; smooth endoplasmic reticulum membrane","Metabolism","formimidoyltransferase cyclodeaminase","http://www.ncbi.nlm.nih.gov/gene/?term=10841","10841","14317","89833",null,null,null,"O95954","Q91XD4","O88618","A0A8P0NE33","I3LDH7","A0A1D5RE35","GO:0005814; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0005793; GO:0070062; GO:0005794; GO:0000139; GO:0005886; GO:0030868","GO:0003824; GO:0005542; GO:0030412; GO:0030409; GO:0016829; GO:0008017; GO:0005515; GO:0016740","GO:0007010; GO:0006760; GO:0019556; GO:0019557; GO:0006547; GO:0008152","PTHR12234:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3974|UniProtKB=O95954"]
["Fyn",null,"FYN","59","rb",null,2,2,6,6,1,7,"# 1326",".CADH., .CSP., .DI., .DRR., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INT., .LMIG., .MIG., .NFKB., .OP., .OPA., .OT., .OXS., .PARK., .PLAT., .RTK., .SREME., .ST., .STAT., .TCR., .TRASR., .UBI., .VEGFS.","Cadherin signaling pathway; Integrin signalling pathway; Axon guidance mediated by semaphorins; Parkinson disease","TYROSINE-PROTEIN KINASE FYN","activated T cell proliferation; adaptive immune response; axon guidance; calcium ion transport; cell differentiation; cell surface receptor signaling pathway; cellular response to amyloid-beta; cellular response to glycine; cellular response to hydrogen peroxide; cellular response to L-glutamate; cellular response to platelet-derived growth factor stimulus; cellular response to transforming growth factor beta stimulus; dendrite morphogenesis; dendritic spine maintenance; detection of mechanical stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; feeding behavior; forebrain development; heart process; I-kappaB kinase/NF-kappaB signaling; immune system process; innate immune response; intracellular signal transduction; learning; leukocyte migration; modulation of chemical synaptic transmission; negative regulation of dendritic spine maintenance; negative regulation of gene expression; negative regulation of hydrogen peroxide biosynthetic process; negative regulation of inflammatory response to antigenic stimulus; negative regulation of oxidative stress-induced cell death; negative regulation of protein catabolic process; negative regulation of protein ubiquitination; neuron migration; neuron projection development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cysteine-type endopeptidase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of neuron death; positive regulation of neuron projection development; positive regulation of protein localization to membrane; positive regulation of protein localization to nucleus; positive regulation of protein targeting to membrane; positive regulation of tyrosine phosphorylation of STAT protein; protein autophosphorylation; protein catabolic process; protein phosphorylation; protein ubiquitination; regulation of calcium ion import across plasma membrane; regulation of cell shape; regulation of glutamate receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation; response to amyloid-beta; response to ethanol; response to singlet oxygen; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","alpha-tubulin binding; ATP binding; disordered domain specific binding; enzyme binding; ephrin receptor binding; G protein-coupled receptor binding; growth factor receptor binding; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phospholipase activator activity; phospholipase binding; protein binding; protein kinase activity; protein tyrosine kinase activity; scaffold protein binding; signaling receptor binding; tau protein binding; tau-protein kinase activity; transferase activity; transmembrane transporter binding; tubulin binding; type 5 metabotropic glutamate receptor binding","actin filament; cell body; cell periphery; cytoplasm; cytosol; dendrite; endosome; extrinsic component of cytoplasmic side of plasma membrane; glial cell projection; membrane; membrane raft; mitochondrion; nucleus; perikaryon; perinuclear endoplasmic reticulum; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; Schaffer collateral - CA1 synapse",null,"FYN proto-oncogene, Src family tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=2534","2534","14360","25150","475032","791125",null,"P06241","P39688","Q62844","A0A8I3NYU1","A1Y2K1","A0A5F7Z853","GO:0005884; GO:0044297; GO:0071944; GO:0005737; GO:0005829; GO:0030425; GO:0005768; GO:0031234; GO:0097386; GO:0016020; GO:0045121; GO:0005739; GO:0005634; GO:0043204; GO:0097038; GO:0048471; GO:0005886; GO:0014069; GO:0098685","GO:0043014; GO:0005524; GO:0097718; GO:0019899; GO:0046875; GO:0001664; GO:0070851; GO:0042802; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0016004; GO:0043274; GO:0005515; GO:0004672; GO:0004713; GO:0097110; GO:0005102; GO:0048156; GO:0050321; GO:0016740; GO:0044325; GO:0015631; GO:0031802","GO:0050798; GO:0002250; GO:0007411; GO:0006816; GO:0030154; GO:0007166; GO:1904646; GO:1905430; GO:0070301; GO:1905232; GO:0036120; GO:0071560; GO:0048813; GO:0097062; GO:0050966; GO:0048013; GO:0038096; GO:0007631; GO:0030900; GO:0003015; GO:0007249; GO:0002376; GO:0045087; GO:0035556; GO:0007612; GO:0050900; GO:0050804; GO:1902951; GO:0010629; GO:0010730; GO:0002862; GO:1903202; GO:0042177; GO:0031397; GO:0001764; GO:0031175; GO:0018108; GO:0016310; GO:2001056; GO:0043123; GO:1901216; GO:0010976; GO:1905477; GO:1900182; GO:0090314; GO:0042531; GO:0046777; GO:0030163; GO:0006468; GO:0016567; GO:1905664; GO:0008360; GO:1900449; GO:0050730; GO:1904645; GO:0045471; GO:0000304; GO:0002223; GO:0031295; GO:0050852; GO:0007169; GO:0048010","PTHR24418:SF44","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4037|UniProtKB=P06241","P00012; P00034; P00007; P00049"]
["Fyn - phospho","Tyr530","FYN","59","rb",null,2,2,2,6,8,8,"# 1338",".CADH., .CSP., .DI., .DRR., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INT., .LMIG., .MIG., .NFKB., .OP., .OPA., .OT., .OXS., .PARK., .PLAT., .RTK., .SREME., .ST., .STAT., .TCR., .TRASR., .UBI., .VEGFS.","Cadherin signaling pathway; Integrin signalling pathway; Axon guidance mediated by semaphorins; Parkinson disease","TYROSINE-PROTEIN KINASE FYN","activated T cell proliferation; adaptive immune response; axon guidance; calcium ion transport; cell differentiation; cell surface receptor signaling pathway; cellular response to amyloid-beta; cellular response to glycine; cellular response to hydrogen peroxide; cellular response to L-glutamate; cellular response to platelet-derived growth factor stimulus; cellular response to transforming growth factor beta stimulus; dendrite morphogenesis; dendritic spine maintenance; detection of mechanical stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; feeding behavior; forebrain development; heart process; I-kappaB kinase/NF-kappaB signaling; immune system process; innate immune response; intracellular signal transduction; learning; leukocyte migration; modulation of chemical synaptic transmission; negative regulation of dendritic spine maintenance; negative regulation of gene expression; negative regulation of hydrogen peroxide biosynthetic process; negative regulation of inflammatory response to antigenic stimulus; negative regulation of oxidative stress-induced cell death; negative regulation of protein catabolic process; negative regulation of protein ubiquitination; neuron migration; neuron projection development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cysteine-type endopeptidase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of neuron death; positive regulation of neuron projection development; positive regulation of protein localization to membrane; positive regulation of protein localization to nucleus; positive regulation of protein targeting to membrane; positive regulation of tyrosine phosphorylation of STAT protein; protein autophosphorylation; protein catabolic process; protein phosphorylation; protein ubiquitination; regulation of calcium ion import across plasma membrane; regulation of cell shape; regulation of glutamate receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation; response to amyloid-beta; response to ethanol; response to singlet oxygen; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","alpha-tubulin binding; ATP binding; disordered domain specific binding; enzyme binding; ephrin receptor binding; G protein-coupled receptor binding; growth factor receptor binding; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phospholipase activator activity; phospholipase binding; protein binding; protein kinase activity; protein tyrosine kinase activity; scaffold protein binding; signaling receptor binding; tau protein binding; tau-protein kinase activity; transferase activity; transmembrane transporter binding; tubulin binding; type 5 metabotropic glutamate receptor binding","actin filament; cell body; cell periphery; cytoplasm; cytosol; dendrite; endosome; extrinsic component of cytoplasmic side of plasma membrane; glial cell projection; membrane; membrane raft; mitochondrion; nucleus; perikaryon; perinuclear endoplasmic reticulum; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; Schaffer collateral - CA1 synapse",null,"FYN proto-oncogene, Src family tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=2534","2534","14360","25150","475032","791125",null,"P06241","P39688","Q62844","A0A8I3NYU1","A1Y2K1","A0A5F7Z853","GO:0005884; GO:0044297; GO:0071944; GO:0005737; GO:0005829; GO:0030425; GO:0005768; GO:0031234; GO:0097386; GO:0016020; GO:0045121; GO:0005739; GO:0005634; GO:0043204; GO:0097038; GO:0048471; GO:0005886; GO:0014069; GO:0098685","GO:0043014; GO:0005524; GO:0097718; GO:0019899; GO:0046875; GO:0001664; GO:0070851; GO:0042802; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0016004; GO:0043274; GO:0005515; GO:0004672; GO:0004713; GO:0097110; GO:0005102; GO:0048156; GO:0050321; GO:0016740; GO:0044325; GO:0015631; GO:0031802","GO:0050798; GO:0002250; GO:0007411; GO:0006816; GO:0030154; GO:0007166; GO:1904646; GO:1905430; GO:0070301; GO:1905232; GO:0036120; GO:0071560; GO:0048813; GO:0097062; GO:0050966; GO:0048013; GO:0038096; GO:0007631; GO:0030900; GO:0003015; GO:0007249; GO:0002376; GO:0045087; GO:0035556; GO:0007612; GO:0050900; GO:0050804; GO:1902951; GO:0010629; GO:0010730; GO:0002862; GO:1903202; GO:0042177; GO:0031397; GO:0001764; GO:0031175; GO:0018108; GO:0016310; GO:2001056; GO:0043123; GO:1901216; GO:0010976; GO:1905477; GO:1900182; GO:0090314; GO:0042531; GO:0046777; GO:0030163; GO:0006468; GO:0016567; GO:1905664; GO:0008360; GO:1900449; GO:0050730; GO:1904645; GO:0045471; GO:0000304; GO:0002223; GO:0031295; GO:0050852; GO:0007169; GO:0048010","PTHR24418:SF44","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4037|UniProtKB=P06241","P00012; P00034; P00007; P00049"]
["Gab1",null,"GAB1","110","rb",null,6,2,2,6,8,8,"TK # 097",".ANG., .CANCER., .CSP., .EGFR., .INS., .MIG., .OP., .OPA., .OT., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST.","PDGF signaling pathway; EGF receptor signaling pathway","GRB2-ASSOCIATED-BINDING PROTEIN 1","actin cytoskeleton reorganization; angiogenesis; endothelial cell chemotaxis to vascular endothelial growth factor; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; response to hepatocyte growth factor; signal transduction; vascular endothelial growth factor signaling pathway","protein binding; signaling adaptor activity","cell-cell junction; cytoplasm; cytosol","Tyrosine kinase / adaptor","GRB2 associated binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=2549","2549","14388",null,null,null,null,"Q13480","Q9QYY0","C6JUQ2","A0A8I3NXB8","K7GMT0","A0A5F7ZB73","GO:0005911; GO:0005737; GO:0005829","GO:0005515; GO:0035591","GO:0031532; GO:0001525; GO:0090668; GO:0007173; GO:0008286; GO:0045766; GO:0038089; GO:0035728; GO:0007165; GO:0038084","PTHR45960:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4066|UniProtKB=Q13480","P00047; P00018"]
["Gab1 - phospho","Tyr307","GAB1","115","rb",null,6,2,2.1,8,8,8,"TK # 098",".ANG., .CANCER., .CSP., .EGFR., .INS., .MIG., .OP., .OPA., .OT., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST.","PDGF signaling pathway; EGF receptor signaling pathway","GRB2-ASSOCIATED-BINDING PROTEIN 1","actin cytoskeleton reorganization; angiogenesis; endothelial cell chemotaxis to vascular endothelial growth factor; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; response to hepatocyte growth factor; signal transduction; vascular endothelial growth factor signaling pathway","protein binding; signaling adaptor activity","cell-cell junction; cytoplasm; cytosol","Tyrosine kinase / adaptor","GRB2 associated binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=2549","2549","14388",null,null,null,null,"Q13480","Q9QYY0","C6JUQ2","A0A8I3NXB8","K7GMT0","A0A5F7ZB73","GO:0005911; GO:0005737; GO:0005829","GO:0005515; GO:0035591","GO:0031532; GO:0001525; GO:0090668; GO:0007173; GO:0008286; GO:0045766; GO:0038089; GO:0035728; GO:0007165; GO:0038084","PTHR45960:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4066|UniProtKB=Q13480","P00047; P00018"]
["Gab1 - phospho","Tyr627","GAB1","115","rb",null,7,4,"n/a","n/a","n/a","n/a","TK # 079",".ANG., .CANCER., .CSP., .EGFR., .INS., .MIG., .OP., .OPA., .OT., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST.","PDGF signaling pathway; EGF receptor signaling pathway","GRB2-ASSOCIATED-BINDING PROTEIN 1","actin cytoskeleton reorganization; angiogenesis; endothelial cell chemotaxis to vascular endothelial growth factor; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; response to hepatocyte growth factor; signal transduction; vascular endothelial growth factor signaling pathway","protein binding; signaling adaptor activity","cell-cell junction; cytoplasm; cytosol","Tyrosine kinase / adaptor","GRB2 associated binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=2549","2549","14388",null,null,null,null,"Q13480","Q9QYY0","C6JUQ2","A0A8I3NXB8","K7GMT0","A0A5F7ZB73","GO:0005911; GO:0005737; GO:0005829","GO:0005515; GO:0035591","GO:0031532; GO:0001525; GO:0090668; GO:0007173; GO:0008286; GO:0045766; GO:0038089; GO:0035728; GO:0007165; GO:0038084","PTHR45960:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4066|UniProtKB=Q13480","P00047; P00018"]
["Gab2",null,"GAB2","90","rb",null,2,4,8.1,8,4,4,"# 1185",".CANCER., .CCP., .CML., .CP., .CSP., .EGFR., .OP., .OPA., .PDGF., .PI3K., .RAS., .RTK., .ST.","PDGF signaling pathway; EGF receptor signaling pathway","GRB2-ASSOCIATED-BINDING PROTEIN 2","osteoclast differentiation; phosphatidylinositol-mediated signaling; positive regulation of cell population proliferation; positive regulation of mast cell degranulation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; signaling adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity","cytoplasm; cytosol; membrane; plasma membrane","Tyrosine kinase / adaptor","GRB2 associated binding protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=9846","9846","14389","84477","608831",null,"700197","Q9UQC2","Q3ZB57","F1LSR2","A0A8I3N369","A0A287B630","F6VIK2","GO:0005737; GO:0005829; GO:0016020; GO:0005886","GO:0005547; GO:0043325; GO:0005515; GO:0035591; GO:0005068","GO:0030316; GO:0048015; GO:0008284; GO:0043306; GO:0007165; GO:0007169","PTHR45960:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=14458|UniProtKB=Q9UQC2","P00047; P00018"]
["Gab2 - phospho","Ser159","GAB2","98","rb",null,6,2,7,8,6,6,"# 1508",".CANCER., .CCP., .CML., .CP., .CSP., .EGFR., .OP., .OPA., .PDGF., .PI3K., .RAS., .RTK., .ST.","PDGF signaling pathway; EGF receptor signaling pathway","GRB2-ASSOCIATED-BINDING PROTEIN 2","osteoclast differentiation; phosphatidylinositol-mediated signaling; positive regulation of cell population proliferation; positive regulation of mast cell degranulation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; signaling adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity","cytoplasm; cytosol; membrane; plasma membrane","Tyrosine kinase / adaptor","GRB2 associated binding protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=9846","9846","14389","84477","608831",null,"700197","Q9UQC2","Q3ZB57","F1LSR2","A0A8I3N369","A0A287B630","F6VIK2","GO:0005737; GO:0005829; GO:0016020; GO:0005886","GO:0005547; GO:0043325; GO:0005515; GO:0035591; GO:0005068","GO:0030316; GO:0048015; GO:0008284; GO:0043306; GO:0007165; GO:0007169","PTHR45960:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=14458|UniProtKB=Q9UQC2","P00047; P00018"]
["Gab2 - phospho","Tyr452","GAB2","98","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1507",".CANCER., .CCP., .CML., .CP., .CSP., .EGFR., .OP., .OPA., .PDGF., .PI3K., .RAS., .RTK., .ST.","PDGF signaling pathway; EGF receptor signaling pathway","GRB2-ASSOCIATED-BINDING PROTEIN 2","osteoclast differentiation; phosphatidylinositol-mediated signaling; positive regulation of cell population proliferation; positive regulation of mast cell degranulation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; signaling adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity","cytoplasm; cytosol; membrane; plasma membrane","Tyrosine kinase / adaptor","GRB2 associated binding protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=9846","9846","14389","84477","608831",null,"700197","Q9UQC2","Q3ZB57","F1LSR2","A0A8I3N369","A0A287B630","F6VIK2","GO:0005737; GO:0005829; GO:0016020; GO:0005886","GO:0005547; GO:0043325; GO:0005515; GO:0035591; GO:0005068","GO:0030316; GO:0048015; GO:0008284; GO:0043306; GO:0007165; GO:0007169","PTHR45960:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=14458|UniProtKB=Q9UQC2","P00047; P00018"]
["GADD45 alpha",null,"GADD45A","22","rb",null,2,1,1,2,2,1.1000000000000001,"# 1201",".ANG., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CRC., .CSP., .DDR., .DREP., .EMC., .FOXO., .GLI., .IMUF., .JNK., .MAPK., .MEL., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .P38., .P53S., .PAC., .PI3K., .RTK., .SCLC., .SREME., .ST., .TRASR., .TYR.","p38 MAPK pathway; p53 pathway; PI3 kinase pathway","GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA","apoptotic process; cell cycle; cellular response to DNA damage stimulus; cellular response to ionizing radiation; cellular response to mechanical stimulus; centrosome cycle; DNA repair; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of peptidyl-serine phosphorylation of STAT protein; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of JNK cascade; positive regulation of p38MAPK cascade; positive regulation of reactive oxygen species metabolic process; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; signal transduction in response to DNA damage","kinase binding; promoter-specific chromatin binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein N-terminus binding","cytoplasm; nuclear speck; nucleoplasm; nucleus","Cell cycle controll","growth arrest and DNA damage inducible alpha","http://www.ncbi.nlm.nih.gov/gene/?term=1647","1647","13197",null,null,null,null,"P24522","P48316","A0A8I6GBV3","A0A8P0P7I3",null,null,"GO:0005737; GO:0016607; GO:0005654; GO:0005634","GO:0019900; GO:1990841; GO:0005515; GO:0046982; GO:0042803; GO:0047485","GO:0006915; GO:0007049; GO:0006974; GO:0071479; GO:0071260; GO:0007098; GO:0006281; GO:0016525; GO:0043537; GO:0033140; GO:0006469; GO:0071901; GO:0000122; GO:0043065; GO:0046330; GO:1900745; GO:2000379; GO:0051726; GO:0000079; GO:0042770","PTHR10411:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4095|UniProtKB=P24522","P05918; P00059; P00048"]
["GADD45 beta",null,"GADD45B","18","rb",null,1,1,1,1,1,1,"# 1406",".APO., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CRC., .CSP., .EMC., .FOXO., .GLI., .IMUF., .JNK., .MAPK., .MEL., .NFKB., .NSCLC., .OP., .OPA., .P38., .P53S., .PAC., .RTK., .SCLC., .SREME., .ST., .TYR.","p53 pathway","GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA","apoptotic process; cell differentiation; negative regulation of protein kinase activity; positive regulation of apoptotic process; positive regulation of JNK cascade; positive regulation of MAPK cascade; positive regulation of p38MAPK cascade; regulation of cell cycle","protein binding","cytoplasm; nucleus","Apoptosis","growth arrest and DNA damage inducible beta","http://www.ncbi.nlm.nih.gov/gene/?term=4616","4616","17873","299626","485069","100621090","711257","O75293","P22339","Q5U3Z2","A0A8I3RWN6","I3L775","F7EBI6","GO:0005737; GO:0005634","GO:0005515","GO:0006915; GO:0030154; GO:0006469; GO:0043065; GO:0046330; GO:0043410; GO:1900745; GO:0051726","PTHR10411:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4096|UniProtKB=O75293","P00059"]
["gamma-Catenin",null,"JUP","83","rb",null,1,1,1,8,1,2.1,"# 1472",".ALZ., .AML., .ANG., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .DEV., .DI., .MIG., .OP., .OT., .TRASR., .WNT.","Alzheimer disease-presenilin pathway","JUNCTION PLAKOGLOBIN","bundle of His cell-Purkinje myocyte adhesion involved in cell communication; canonical Wnt signaling pathway; cell adhesion; cell migration; cell-cell adhesion; cellular response to indole-3-methanol; desmosome assembly; detection of mechanical stimulus; endothelial cell-cell adhesion; negative regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of canonical Wnt signaling pathway; positive regulation of cell-matrix adhesion; positive regulation of DNA-binding transcription factor activity; positive regulation of protein import into nucleus; positive regulation of transcription by RNA polymerase II; protein localization to plasma membrane; regulation of cell population proliferation; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; skin development","alpha-catenin binding; cadherin binding; cell adhesion molecule binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; cytoskeletal protein-membrane anchor activity; DNA-binding transcription factor binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase binding; protein-containing complex binding; structural molecule activity; transcription coactivator activity","actin cytoskeleton; adherens junction; anchoring junction; apicolateral plasma membrane; catenin complex; cell-cell junction; cornified envelope; cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; desmosome; extracellular exosome; extracellular region; fascia adherens; ficolin-1-rich granule lumen; focal adhesion; gamma-catenin-TCF7L2 complex; hemidesmosome; intercalated disc; intermediate filament; lateral plasma membrane; membrane; nucleus; plasma membrane; protein-DNA complex; specific granule lumen; Z disc; zonula adherens","Adhesion","junction plakoglobin","http://www.ncbi.nlm.nih.gov/gene/?term=3728","3728","16480","81679",null,null,null,"P14923","Q02257","Q6P0K8","A0A8I3NL10","A0A2C9F3E9","A0A5F7ZES7","GO:0015629; GO:0005912; GO:0070161; GO:0016327; GO:0016342; GO:0005911; GO:0001533; GO:0005737; GO:0009898; GO:0005856; GO:0005829; GO:0030057; GO:0070062; GO:0005576; GO:0005916; GO:1904813; GO:0005925; GO:0071665; GO:0030056; GO:0014704; GO:0005882; GO:0016328; GO:0016020; GO:0005634; GO:0005886; GO:0032993; GO:0035580; GO:0030018; GO:0005915","GO:0045294; GO:0045296; GO:0050839; GO:0086083; GO:0106006; GO:0140297; GO:0005515; GO:0042803; GO:0019901; GO:0019903; GO:1990782; GO:0044877; GO:0005198; GO:0003713","GO:0086073; GO:0060070; GO:0007155; GO:0016477; GO:0098609; GO:0071681; GO:0002159; GO:0050982; GO:0071603; GO:0043537; GO:0045766; GO:0090263; GO:0001954; GO:0051091; GO:0042307; GO:0045944; GO:0072659; GO:0042127; GO:0086091; GO:0098911; GO:0043588","PTHR45976:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6207|UniProtKB=P14923","P00004"]
["GAPDH",null,"GAPDH","37","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2791",".ALZ., .APH., .APO., .CD., .CSP., .DI., .HIF., .HUNT., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OT., .SREME., .TRASR.","Huntington disease; Glycolysis","GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE","antimicrobial humoral immune response mediated by antimicrobial peptide; apoptotic process; cellular response to type II interferon; defense response to fungus; glucose metabolic process; glycolytic process; immune system process; innate immune response; killing by host of symbiont cells; killing of cells of another organism; microtubule cytoskeleton organization; negative regulation of endopeptidase activity; negative regulation of translation; neuron apoptotic process; peptidyl-cysteine S-trans-nitrosylation; positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of type I interferon production; protein stabilization; regulation of macroautophagy; regulation of translation","aspartic-type endopeptidase inhibitor activity; disordered domain specific binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; identical protein binding; microtubule binding; NAD binding; NADP binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; peptidyl-cysteine S-nitrosylase activity; protein binding; transferase activity","cytoplasm; cytoskeleton; cytosol; extracellular exosome; GAIT complex; intracellular membrane-bounded organelle; lipid droplet; membrane; microtubule cytoskeleton; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; ribonucleoprotein complex; vesicle","Metabolism","glyceraldehyde-3-phosphate dehydrogenase","http://www.ncbi.nlm.nih.gov/gene/?term=2597","2597","14433",null,null,null,"574353","P04406","P16858",null,null,null,"I2CWU4","GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0097452; GO:0043231; GO:0005811; GO:0016020; GO:0015630; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:1990904; GO:0031982","GO:0019828; GO:0097718; GO:0004365; GO:0042802; GO:0008017; GO:0051287; GO:0050661; GO:0016491; GO:0016620; GO:0035605; GO:0005515; GO:0016740","GO:0061844; GO:0006915; GO:0071346; GO:0050832; GO:0006006; GO:0006096; GO:0002376; GO:0045087; GO:0051873; GO:0031640; GO:0000226; GO:0010951; GO:0017148; GO:0051402; GO:0035606; GO:0001819; GO:0043123; GO:0032481; GO:0050821; GO:0016241; GO:0006417","PTHR10836:SF111","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4141|UniProtKB=P04406","P00029; P00024"]
["GAPDH",null,"GAPDH","37","ms",null,1,1,"n/a","n/a","n/a","n/a","# 2222",".ALZ., .APH., .APO., .CD., .CSP., .DI., .HIF., .HUNT., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OT., .SREME., .TRASR.","Huntington disease; Glycolysis","GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE","antimicrobial humoral immune response mediated by antimicrobial peptide; apoptotic process; cellular response to type II interferon; defense response to fungus; glucose metabolic process; glycolytic process; immune system process; innate immune response; killing by host of symbiont cells; killing of cells of another organism; microtubule cytoskeleton organization; negative regulation of endopeptidase activity; negative regulation of translation; neuron apoptotic process; peptidyl-cysteine S-trans-nitrosylation; positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of type I interferon production; protein stabilization; regulation of macroautophagy; regulation of translation","aspartic-type endopeptidase inhibitor activity; disordered domain specific binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; identical protein binding; microtubule binding; NAD binding; NADP binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; peptidyl-cysteine S-nitrosylase activity; protein binding; transferase activity","cytoplasm; cytoskeleton; cytosol; extracellular exosome; GAIT complex; intracellular membrane-bounded organelle; lipid droplet; membrane; microtubule cytoskeleton; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; ribonucleoprotein complex; vesicle","Metabolism","glyceraldehyde-3-phosphate dehydrogenase","http://www.ncbi.nlm.nih.gov/gene/?term=2597","2597","14433",null,null,null,"574353","P04406","P16858",null,null,null,"I2CWU4","GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0097452; GO:0043231; GO:0005811; GO:0016020; GO:0015630; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:1990904; GO:0031982","GO:0019828; GO:0097718; GO:0004365; GO:0042802; GO:0008017; GO:0051287; GO:0050661; GO:0016491; GO:0016620; GO:0035605; GO:0005515; GO:0016740","GO:0061844; GO:0006915; GO:0071346; GO:0050832; GO:0006006; GO:0006096; GO:0002376; GO:0045087; GO:0051873; GO:0031640; GO:0000226; GO:0010951; GO:0017148; GO:0051402; GO:0035606; GO:0001819; GO:0043123; GO:0032481; GO:0050821; GO:0016241; GO:0006417","PTHR10836:SF111","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4141|UniProtKB=P04406","P00029; P00024"]
["Gas1",null,"GAS1","36","gt",null,6,4,"n/a","n/a","n/a","n/a","# 1425",".APO., .CCP., .CCY., .CD., .CSP., .DEV., .HHSP., .OP., .OT., .TRASR.",null,"GROWTH ARREST-SPECIFIC PROTEIN 1","cell cycle; cell fate commitment; cellular response to vascular endothelial growth factor stimulus; developmental growth; negative regulation of mitotic cell cycle; negative regulation of protein processing; regulation of apoptotic process; regulation of cell cycle; regulation of ER to Golgi vesicle-mediated transport; regulation of smoothened signaling pathway","protein binding","membrane; plasma membrane","Growth suppression","growth arrest specific 1","http://www.ncbi.nlm.nih.gov/gene/?term=2619","2619","14451",null,null,null,null,"P54826","Q01721",null,null,null,null,"GO:0016020; GO:0005886","GO:0005515","GO:0007049; GO:0045165; GO:0035924; GO:0048589; GO:0045930; GO:0010955; GO:0042981; GO:0051726; GO:0060628; GO:0008589","PTHR16840:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4165|UniProtKB=P54826"]
["GAS2",null,"GAS2","35","rb",null,7,1,1,1,2,2,"# 1394",".APO., .CCP., .CCY., .CD., .CSP., .DEV., .NOTCH., .OP.",null,"GROWTH ARREST-SPECIFIC PROTEIN 2","actin crosslink formation; antral ovarian follicle growth; apoptotic process; basement membrane organization; cell cycle; initiation of primordial ovarian follicle growth; ovulation; regulation of cell cycle; regulation of cell shape; regulation of Notch signaling pathway","actin filament binding; cytoskeletal anchor activity; microtubule binding","actin filament; cytoplasm; cytoskeleton; cytosol; membrane","Apoptosis","growth arrest specific 2","http://www.ncbi.nlm.nih.gov/gene/?term=2620","2620","14453","499156",null,null,"700952","O43903","P11862","G3V857","A0A8I3PIZ1",null,"F7HSM4","GO:0005884; GO:0005737; GO:0005856; GO:0005829; GO:0016020","GO:0051015; GO:0008093; GO:0008017","GO:0051764; GO:0001547; GO:0006915; GO:0071711; GO:0007049; GO:0001544; GO:0030728; GO:0051726; GO:0008360; GO:0008593","PTHR46756:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4167|UniProtKB=O43903"]
["GCN5L2",null,"KAT2A","94","rb",null,1,4,4,4,4,4,"# 1022",".CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .DREP., .IMUF., .NOTCH., .OP., .OT., .TCD., .TCR., .TMAT., .TNF., .TRASR., .UBI.",null,"HISTONE ACETYLTRANSFERASE KAT2A","alpha-tubulin acetylation; cellular response to nerve growth factor stimulus; cellular response to tumor necrosis factor; chromatin remodeling; fibroblast proliferation; gluconeogenesis; heart development; histone acetylation; histone deubiquitination; histone H3 acetylation; histone H3-K14 acetylation; histone succinylation; in utero embryonic development; internal peptidyl-lysine acetylation; intracellular distribution of mitochondria; limb development; long-term memory; metencephalon development; midbrain development; monoubiquitinated histone deubiquitination; monoubiquitinated histone H2A deubiquitination; multicellular organism growth; negative regulation of centriole replication; nervous system development; neural tube closure; peptidyl-lysine glutarylation; positive regulation of cardiac muscle cell differentiation; positive regulation of cell projection organization; positive regulation of cytokine production; positive regulation of DNA-templated transcription; positive regulation of gluconeogenesis; positive regulation of histone modification; positive regulation of transcription by RNA polymerase II; regulation of bone development; regulation of cartilage development; regulation of cell cycle; regulation of cell division; regulation of DNA repair; regulation of DNA-templated transcription; regulation of embryonic development; regulation of histone deacetylation; regulation of protein stability; regulation of regulatory T cell differentiation; regulation of RNA splicing; regulation of stem cell population maintenance; regulation of synaptic plasticity; regulation of T cell activation; regulation of transcription by RNA polymerase II; regulation of tubulin deacetylation; response to nutrient levels; response to organic cyclic compound; somitogenesis; telencephalon development","acetyltransferase activity; acyltransferase activity; acyltransferase activity, transferring groups other than amino-acyl groups; chromatin binding; DNA-binding transcription factor binding; histone acetyltransferase activity; histone deacetylase binding; histone glutaryltransferase activity; histone H3 acetyltransferase activity; histone H3K18 acetyltransferase activity; histone H3K9 acetyltransferase activity; histone H4K12 acetyltransferase activity; histone succinyltransferase activity; N-acetyltransferase activity; peptide glutaryltransferase activity; peptide-lysine-N-acetyltransferase activity; protein binding; protein phosphatase binding; transcription coactivator activity; transferase activity","ATAC complex; centrosome; chromatin; chromosome; cytoplasm; cytoskeleton; extracellular space; histone acetyltransferase complex; microtubule organizing center; mitotic spindle; nucleoplasm; nucleus; oxoglutarate dehydrogenase complex; SAGA complex; transcription factor TFTC complex","Chromatin regulation / epigenetics","lysine acetyltransferase 2A","http://www.ncbi.nlm.nih.gov/gene/?term=2648","2648","14534","303539",null,null,null,"Q92830","Q9JHD2","D4ACX5","A0A8P0NGZ2","A0A287ASY2","A0A1D5Q6J9","GO:0140672; GO:0005813; GO:0000785; GO:0005694; GO:0005737; GO:0005856; GO:0005615; GO:0000123; GO:0005815; GO:0072686; GO:0005654; GO:0005634; GO:0045252; GO:0000124; GO:0033276","GO:0016407; GO:0016746; GO:0016747; GO:0003682; GO:0140297; GO:0004402; GO:0042826; GO:0106229; GO:0010484; GO:0043993; GO:0043992; GO:0043997; GO:0106078; GO:0008080; GO:0106228; GO:0061733; GO:0005515; GO:0019903; GO:0003713; GO:0016740","GO:0071929; GO:1990090; GO:0071356; GO:0006338; GO:0048144; GO:0006094; GO:0007507; GO:0016573; GO:0016578; GO:0043966; GO:0044154; GO:0106077; GO:0001701; GO:0018393; GO:0048312; GO:0060173; GO:0007616; GO:0022037; GO:0030901; GO:0035521; GO:0035522; GO:0035264; GO:0046600; GO:0007399; GO:0001843; GO:0106227; GO:2000727; GO:0031346; GO:0001819; GO:0045893; GO:0045722; GO:0031058; GO:0045944; GO:1903010; GO:0061035; GO:0051726; GO:0051302; GO:0006282; GO:0006355; GO:0045995; GO:0031063; GO:0031647; GO:0045589; GO:0043484; GO:2000036; GO:0048167; GO:0050863; GO:0006357; GO:0090043; GO:0031667; GO:0014070; GO:0001756; GO:0021537","PTHR45750:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4201|UniProtKB=Q92830"]
["GDF3",null,"GDF3","45, 18","rb",null,1,1,1,1,1,1,"# 0935",".BMP., .CSP., .DEV., .OPA., .ST., .TGFB.","TGF-beta signaling pathway","GROWTH/DIFFERENTIATION FACTOR 3","BMP signaling pathway; endoderm development; eye development; formation of anatomical boundary; in utero embryonic development; mesoderm development; negative regulation of BMP signaling pathway; negative regulation of epidermal cell differentiation; negative regulation of myoblast differentiation; notochord development; positive regulation of fat cell differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; primitive streak formation; regulation of cell fate commitment; response to dietary excess; signal transduction; skeletal system development; SMAD protein signal transduction; somite rostral/caudal axis specification","cytokine activity; growth factor activity; protein kinase binding","cytoplasm; extracellular region; extracellular space","Cell growth / differentiation / TGF-beta signaling / stem cell marker","growth differentiation factor 3","http://www.ncbi.nlm.nih.gov/gene/?term=9573","9573","14562","500311","477702",null,null,"Q9NR23","Q07104","A2SY89","A0A8I3Q963","F1SLW3",null,"GO:0005737; GO:0005576; GO:0005615","GO:0005125; GO:0008083; GO:0019901","GO:0030509; GO:0007492; GO:0001654; GO:0048859; GO:0001701; GO:0007498; GO:0030514; GO:0045605; GO:0045662; GO:0030903; GO:0045600; GO:0010862; GO:0090009; GO:0010453; GO:0002021; GO:0007165; GO:0001501; GO:0060395; GO:0032525","PTHR11848:SF38","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4218|UniProtKB=Q9NR23","P00052"]
["GDF8 (Myostatin)",null,"MSTN","33","ms",null,2,7,1,7,7,7,"# 1395",".CCP., .CP., .CSP., .DEV., .DRR., .IMUR., .INS., .LMIG., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TGFB., .TRASR.","TGF-beta signaling pathway","GROWTH/DIFFERENTIATION FACTOR 8","cellular response to dexamethasone stimulus; muscle cell cellular homeostasis; muscle organ development; myoblast migration involved in skeletal muscle regeneration; negative regulation of insulin receptor signaling pathway; negative regulation of kinase activity; negative regulation of muscle hypertrophy; negative regulation of myoblast differentiation; negative regulation of myoblast proliferation; negative regulation of protein kinase B signaling; negative regulation of satellite cell differentiation; negative regulation of skeletal muscle satellite cell proliferation; negative regulation of skeletal muscle tissue growth; ovulation cycle process; positive regulation of DNA-templated transcription; positive regulation of lamellipodium assembly; positive regulation of macrophage chemotaxis; positive regulation of pathway-restricted SMAD protein phosphorylation; response to electrical stimulus; response to estrogen; response to ethanol; response to glucocorticoid; response to gravity; response to heat; response to muscle activity; response to testosterone; skeletal muscle atrophy; skeletal muscle satellite cell differentiation; skeletal muscle tissue regeneration; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway","cytokine activity; growth factor activity; heparin binding; identical protein binding; protein binding; protein homodimerization activity; signaling receptor binding","cytoplasm; extracellular region; extracellular space","Skeletal muscle growth","myostatin","http://www.ncbi.nlm.nih.gov/gene/?term=2660","2660","17700","29152","403433",null,"710114","O14793","O08689","O35312","Q6UKZ8","O18831","A1C2U6","GO:0005737; GO:0005576; GO:0005615","GO:0005125; GO:0008083; GO:0008201; GO:0042802; GO:0005515; GO:0042803; GO:0005102","GO:0071549; GO:0046716; GO:0007517; GO:0014839; GO:0046627; GO:0033673; GO:0014741; GO:0045662; GO:2000818; GO:0051898; GO:1902725; GO:1902723; GO:0048632; GO:0022602; GO:0045893; GO:0010592; GO:0010759; GO:0010862; GO:0051602; GO:0043627; GO:0045471; GO:0051384; GO:0009629; GO:0009408; GO:0014850; GO:0033574; GO:0014732; GO:0014816; GO:0043403; GO:0060395; GO:0007179","PTHR11848:SF278","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4223|UniProtKB=O14793","P00052"]
["GLDC",null,"GLDC","113","rb",null,2.1,2,2.1,1,2,2,"# 1624",null,null,"GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL","amino acid metabolic process; cellular response to leukemia inhibitory factor; electron transport chain; glycine catabolic process; glycine decarboxylation via glycine cleavage system; glycine metabolic process; response to lipoic acid; response to methylamine","catalytic activity; electron transfer activity; glycine binding; glycine dehydrogenase (decarboxylating) activity; lyase activity; oxidoreductase activity; protein homodimerization activity; pyridoxal binding; pyridoxal phosphate binding","glycine cleavage complex; mitochondrial matrix; mitochondrion; nucleoplasm; plasma membrane","Metabolism","glycine decarboxylase","http://www.ncbi.nlm.nih.gov/gene/?term=2731","2731","104174",null,"481534",null,"715563","P23378","Q91W43","A0A0G2JUZ5","A0A8I3PNR0","A0A5G2QHK8","F6PUG5","GO:0005960; GO:0005759; GO:0005739; GO:0005654; GO:0005886","GO:0003824; GO:0009055; GO:0016594; GO:0004375; GO:0016829; GO:0016491; GO:0042803; GO:0070280; GO:0030170","GO:0006520; GO:1990830; GO:0022900; GO:0006546; GO:0019464; GO:0006544; GO:1903442; GO:0036255","PTHR11773:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4313|UniProtKB=P23378"]
["GLI1",null,"GLI1","160","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0678",".cAMP., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .DEV., .GPCR., .HHSP., .OP., .OT., .TRASR., .WNT.","Hedgehog signaling pathway","ZINC FINGER PROTEIN GLI1","cell differentiation; cerebellar cortex morphogenesis; digestive tract morphogenesis; dorsal/ventral pattern formation; epidermal cell differentiation; liver regeneration; lung development; negative regulation of canonical Wnt signaling pathway; negative regulation of hh target transcription factor activity; notochord regression; osteoblast differentiation; pituitary gland development; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle G1/S phase transition; positive regulation of cell population proliferation; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of smoothened signaling pathway; positive regulation of transcription by RNA polymerase II; prostate gland development; proximal/distal pattern formation; regulation of hepatocyte proliferation; regulation of osteoblast differentiation; regulation of smoothened signaling pathway; regulation of transcription by RNA polymerase II; response to wounding; smoothened signaling pathway; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; spermatid development; spermatogenesis; ventral midline development","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; microtubule binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding","axoneme; ciliary base; ciliary tip; cilium; cytoplasm; cytosol; GLI-SUFU complex; nucleoplasm; nucleus","Hedgehog signaling","GLI family zinc finger 1","http://www.ncbi.nlm.nih.gov/gene/?term=2735","2735","14632","140589","481126",null,"714843","P08151","P47806","G3V6X8","A0A8I3NLD9","A0A5K1V436","I0FMN4","GO:0005930; GO:0097546; GO:0097542; GO:0005929; GO:0005737; GO:0005829; GO:1990788; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0001228; GO:0000981; GO:0046872; GO:0008017; GO:0005515; GO:0000978; GO:0000977; GO:0043565; GO:0000976","GO:0030154; GO:0021696; GO:0048546; GO:0009953; GO:0009913; GO:0097421; GO:0030324; GO:0090090; GO:1990787; GO:0060032; GO:0001649; GO:0021983; GO:0060045; GO:1902808; GO:0008284; GO:0045740; GO:0045893; GO:0045880; GO:0045944; GO:0030850; GO:0009954; GO:2000345; GO:0045667; GO:0008589; GO:0006357; GO:0009611; GO:0007224; GO:0021938; GO:0007286; GO:0007283; GO:0007418","PTHR45718:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4317|UniProtKB=P08151","P00025"]
["GLS2 (Glutaminase 2)",null,"GLS2","66","rb",null,2,2,6,2,2,2,"# 1591",".APO., .CAMET., .CANCER., .CD., .CSP., .OP., .OXS., .SREME.",null,"GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL","amino acid metabolic process; glutamate biosynthetic process; glutamine catabolic process; glutamine metabolic process; reactive oxygen species metabolic process; regulation of apoptotic process","glutaminase activity; hydrolase activity; protein binding","mitochondrial matrix; mitochondrion",null,"glutaminase 2","http://www.ncbi.nlm.nih.gov/gene/?term=27165","27165","216456","192268",null,"100738224",null,"Q9UI32","Q571F8","A0A0H2UHL2","A0A8I3MY37","F1SLB4","A0A1D5R0A7","GO:0005759; GO:0005739","GO:0004359; GO:0016787; GO:0005515","GO:0006520; GO:0006537; GO:0006543; GO:0006541; GO:0072593; GO:0042981","PTHR12544:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=29570|UniProtKB=Q9UI32"]
["Glucose 6 phosphatase alpha",null,"G6PC1","40","rb",null,2,2,6,6,8,8,"# 1135",".AMPK., .CSP., .FOXO., .INS., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .TRASR.","Phenylethylamine degradation","GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT 1","cholesterol homeostasis; gluconeogenesis; glucose 6-phosphate metabolic process; glucose homeostasis; glucose-6-phosphate transport; glycogen catabolic process; glycogen metabolic process; multicellular organism growth; regulation of gene expression; steroid metabolic process; triglyceride metabolic process; urate metabolic process","glucose-6-phosphatase activity; hydrolase activity; phosphate ion binding; phosphotransferase activity, alcohol group as acceptor; protein binding","endoplasmic reticulum; endoplasmic reticulum membrane; membrane",null,"glucose-6-phosphatase catalytic subunit 1","http://www.ncbi.nlm.nih.gov/gene/?term=2538","2538","14377",null,null,null,null,"P35575","P35576",null,"A0A8I3MZQ1",null,"A0A1D5QQ89","GO:0005783; GO:0005789; GO:0016020","GO:0004346; GO:0016787; GO:0042301; GO:0016773; GO:0005515","GO:0042632; GO:0006094; GO:0051156; GO:0042593; GO:0015760; GO:0005980; GO:0005977; GO:0035264; GO:0010468; GO:0008202; GO:0006641; GO:0046415","PTHR12591:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4056|UniProtKB=P35575","P02766"]
["GLUT-1",null,"SLC2A1","54","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1596",".CAMET., .CANCER., .CANPTHW., .CSP., .HIF., .INS., .OP., .RCC., .SREME.","Gonadotropin releasing hormone receptor pathway","SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1","carbohydrate transport; cellular hyperosmotic response; cellular response to glucose starvation; cellular response to mechanical stimulus; central nervous system development; cerebral cortex development; dehydroascorbic acid transport; female pregnancy; glucose import; glucose import across plasma membrane; glucose transmembrane transport; L-ascorbic acid metabolic process; long-chain fatty acid import across plasma membrane; monosaccharide transmembrane transport; photoreceptor cell maintenance; protein-containing complex assembly; response to hypoxia; response to insulin; response to osmotic stress; response to Thyroglobulin triiodothyronine; transmembrane transport; transport across blood-brain barrier; xenobiotic transport","dehydroascorbic acid transmembrane transporter activity; D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity; identical protein binding; kinase binding; long-chain fatty acid transporter activity; protein binding; protein self-association; transmembrane transporter activity; xenobiotic transmembrane transporter activity","apical plasma membrane; basolateral plasma membrane; blood microparticle; caveola; cell-cell junction; cortical actin cytoskeleton; cytoplasm; cytosol; extracellular exosome; female germ cell nucleus; female pronucleus; Golgi membrane; intercalated disc; melanosome; membrane; membrane raft; midbody; photoreceptor inner segment; plasma membrane; presynapse; sarcolemma; synapse; vesicle; Z disc",null,"solute carrier family 2 member 1","http://www.ncbi.nlm.nih.gov/gene/?term=6513","6513","20525","24778",null,null,null,"P11166","P17809","P11167","A0A8I3NM58",null,"A0A1D5R1Y8","GO:0016324; GO:0016323; GO:0072562; GO:0005901; GO:0005911; GO:0030864; GO:0005737; GO:0005829; GO:0070062; GO:0001674; GO:0001939; GO:0000139; GO:0014704; GO:0042470; GO:0016020; GO:0045121; GO:0030496; GO:0001917; GO:0005886; GO:0098793; GO:0042383; GO:0045202; GO:0031982; GO:0030018","GO:0033300; GO:0055056; GO:0005355; GO:0015149; GO:0042802; GO:0019900; GO:0005324; GO:0005515; GO:0043621; GO:0022857; GO:0042910","GO:0008643; GO:0071474; GO:0042149; GO:0071260; GO:0007417; GO:0021987; GO:0070837; GO:0007565; GO:0046323; GO:0098708; GO:1904659; GO:0019852; GO:0015911; GO:0015749; GO:0045494; GO:0065003; GO:0001666; GO:0032868; GO:0006970; GO:1904016; GO:0055085; GO:0150104; GO:0042908","PTHR23503:SF51","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11005|UniProtKB=P11166","P06664"]
["GLUT-4 (GLUT4)",null,"SLC2A4","58","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1710",".AMPK., .CD., .CSP., .DRR., .FOXO., .HIF., .INS., .OP., .OPA., .OT., .SREME., .ST., .TNF.",null,"SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 4","amylopectin biosynthetic process; brown fat cell differentiation; carbohydrate metabolic process; carbohydrate transport; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to osmotic stress; cellular response to tumor necrosis factor; glucose homeostasis; glucose import; glucose import in response to insulin stimulus; glucose transmembrane transport; learning or memory; long-term memory; monosaccharide transmembrane transport; positive regulation of brain-derived neurotrophic factor receptor signaling pathway; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane; response to ethanol; short-term memory; transmembrane transport; transport across blood-brain barrier","D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; glucose uniporter activity; hexose transmembrane transporter activity; protein binding; transmembrane transporter activity","cell surface; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle membrane; cytosol; endomembrane system; endosome; external side of plasma membrane; extracellular exosome; insulin-responsive compartment; intracellular membrane-bounded organelle; membrane; membrane raft; multivesicular body; perinuclear region of cytoplasm; plasma membrane; presynapse; sarcolemma; sarcoplasmic reticulum; trans-Golgi network; trans-Golgi network transport vesicle; T-tubule; vesicle; vesicle membrane",null,"solute carrier family 2 member 4","http://www.ncbi.nlm.nih.gov/gene/?term=6517","6517","20528","25139","403673",null,null,"P14672","P14142","P19357","A0A8I3PA13","A0A5G2QJI3","A0A1D5RDJ8","GO:0009986; GO:0005905; GO:0030136; GO:0005737; GO:0030659; GO:0005829; GO:0012505; GO:0005768; GO:0009897; GO:0070062; GO:0032593; GO:0043231; GO:0016020; GO:0045121; GO:0005771; GO:0048471; GO:0005886; GO:0098793; GO:0042383; GO:0016529; GO:0005802; GO:0030140; GO:0030315; GO:0031982; GO:0012506","GO:0055056; GO:0005355; GO:0015304; GO:0015149; GO:0005515; GO:0022857","GO:0010021; GO:0050873; GO:0005975; GO:0008643; GO:0071456; GO:0032869; GO:0071470; GO:0071356; GO:0042593; GO:0046323; GO:0044381; GO:1904659; GO:0007611; GO:0007616; GO:0015749; GO:0031550; GO:0098694; GO:0045471; GO:0007614; GO:0055085; GO:0150104","PTHR23503:SF120","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11009|UniProtKB=P14672"]
["Glutaminase",null,"GLS","65","rb",null,1,4,2,8,4,4,"# 1595",".CAMET., .CANCER., .OP.",null,"GLUTAMINASE KIDNEY ISOFORM, MITOCHONDRIAL","cellular glutamate homeostasis; chemical synaptic transmission; glutamate biosynthetic process; glutamine catabolic process; glutamine metabolic process; protein homotetramerization; regulation of respiratory gaseous exchange by nervous system process; suckling behavior","glutaminase activity; hydrolase activity; protein binding","cytoplasm; cytosol; mitochondrial matrix; mitochondrion; synapse",null,"glutaminase","http://www.ncbi.nlm.nih.gov/gene/?term=2744","2744","14660",null,null,null,null,"O94925","D3Z7P3","A0A0G2K1T0","A0A8I3PVU8","A0A287BFF4","F7AIH5","GO:0005737; GO:0005829; GO:0005759; GO:0005739; GO:0045202","GO:0004359; GO:0016787; GO:0005515","GO:0090461; GO:0007268; GO:0006537; GO:0006543; GO:0006541; GO:0051289; GO:0002087; GO:0001967","PTHR12544:SF49","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4331|UniProtKB=O94925"]
["Glutaminsynthetase",null,"GLUL","45","rb",null,2,1,1,2,2,2,"# 0486",".ANG., .CANCER., .CCP., .CP., .OP.","Glutamine glutamate conversion","GLUTAMINE SYNTHETASE","ammonia assimilation cycle; angiogenesis; cell population proliferation; cellular response to starvation; glutamate catabolic process; glutamate metabolic process; glutamine biosynthetic process; nitrogen compound metabolic process; positive regulation of epithelial cell proliferation; positive regulation of insulin secretion; positive regulation of synaptic transmission, glutamatergic; protein palmitoylation; regulation of endothelial cell migration; regulation of protein localization to nucleolus; regulation of sprouting angiogenesis; response to glucose; ribosome biogenesis","ATP binding; catalytic activity; dynein light chain binding; glutamate binding; glutamate-ammonia ligase activity; identical protein binding; ligase activity; magnesium ion binding; manganese ion binding; metal ion binding; nucleotide binding; protein binding; protein-cysteine S-palmitoyltransferase activity; transferase activity","axon terminus; cell body; cell projection; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; glial cell projection; intracellular membrane-bounded organelle; membrane; mitochondrion; myelin sheath; neuron projection; nucleus; perikaryon; plasma membrane; protein-containing complex; rough endoplasmic reticulum","Metabolism / tumor marker","glutamate-ammonia ligase","http://www.ncbi.nlm.nih.gov/gene/?term=2752","2752","14645",null,null,null,null,"P15104","P15105","A0A8I5Y1V3","A0A8I3MUX9","A0A287AFJ1","A0A5F7ZW72","GO:0043679; GO:0044297; GO:0042995; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0097386; GO:0043231; GO:0016020; GO:0005739; GO:0043209; GO:0043005; GO:0005634; GO:0043204; GO:0005886; GO:0032991; GO:0005791","GO:0005524; GO:0003824; GO:0045503; GO:0016595; GO:0004356; GO:0042802; GO:0016874; GO:0000287; GO:0030145; GO:0046872; GO:0000166; GO:0005515; GO:0019706; GO:0016740","GO:0019676; GO:0001525; GO:0008283; GO:0009267; GO:0006538; GO:0006536; GO:0006542; GO:0006807; GO:0050679; GO:0032024; GO:0051968; GO:0018345; GO:0010594; GO:1904749; GO:1903670; GO:0009749; GO:0042254","PTHR20852:SF45","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4341|UniProtKB=P15104","P02745"]
["Glutathione S Transferase Omega1",null,"GSTO1","28","rb",null,1,4,"n/a","n/a","n/a","n/a","# 1992",".CANCER., .CANPTHW., .DRR., .OP., .OT.",null,"GLUTATHIONE S-TRANSFERASE OMEGA-1","cellular oxidant detoxification; cellular response to arsenic-containing substance; glutathione metabolic process; L-ascorbic acid metabolic process; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; xenobiotic catabolic process","glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; methylarsonate reductase activity; oxidoreductase activity; protein binding; transferase activity","cytoplasm; cytosol; extracellular exosome",null,"glutathione S-transferase omega 1","http://www.ncbi.nlm.nih.gov/gene/?term=9446","9446","14873",null,null,"397117",null,"P78417","O09131","A0A8I5ZZS8","A0A8I3Q1F5","Q9N1F5","F6UJ19","GO:0005737; GO:0005829; GO:0070062","GO:0045174; GO:0004364; GO:0050610; GO:0016491; GO:0005515; GO:0016740","GO:0098869; GO:0071243; GO:0006749; GO:0019852; GO:0060315; GO:0060316; GO:0014810; GO:0010881; GO:0010880; GO:0042178","PTHR43968:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13312|UniProtKB=P78417"]
["Glypican3",null,"GPC3","66","rb",null,4,3,3,8,8,8,"# 1401",".BMP., .CCP., .CP., .CSP., .DEV., .HHSP., .MIG., .OP., .OPA., .OT., .ST., .WNT.",null,"GLYPICAN-3","anatomical structure morphogenesis; animal organ morphogenesis; anterior/posterior axis specification; body morphogenesis; bone mineralization; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; cell migration; cell migration involved in gastrulation; cell proliferation involved in kidney development; cell proliferation involved in metanephros development; coronary vasculature development; embryonic hindlimb morphogenesis; epithelial cell proliferation; kidney development; lung development; mesenchymal cell proliferation involved in ureteric bud development; mesonephric duct morphogenesis; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; negative regulation of epithelial cell proliferation; negative regulation of growth; negative regulation of peptidase activity; negative regulation of smoothened signaling pathway; osteoclast differentiation; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of endocytosis; positive regulation of glucose import; positive regulation of protein catabolic process; positive regulation of smoothened signaling pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; regulation of canonical Wnt signaling pathway; regulation of growth; regulation of non-canonical Wnt signaling pathway; regulation of protein localization to membrane; regulation of signal transduction; response to bacterium; smoothened signaling pathway; Wnt signaling pathway, planar cell polarity pathway","peptidase inhibitor activity; peptidyl-dipeptidase inhibitor activity; protein binding","cell surface; collagen-containing extracellular matrix; endoplasmic reticulum lumen; Golgi lumen; lysosomal lumen; lysosome; membrane; plasma membrane","Tumor regulation","glypican 3","http://www.ncbi.nlm.nih.gov/gene/?term=2719","2719","14734",null,"481056",null,null,"P51654","Q8CFZ4","A0A0G2KBA2","A0A8I3Q662","A0A287A3K8","A0A1D5QAU1","GO:0009986; GO:0062023; GO:0005788; GO:0005796; GO:0043202; GO:0005764; GO:0016020; GO:0005886","GO:0030414; GO:0060422; GO:0005515","GO:0009653; GO:0009887; GO:0009948; GO:0010171; GO:0030282; GO:0001658; GO:0060070; GO:0016477; GO:0042074; GO:0072111; GO:0072203; GO:0060976; GO:0035116; GO:0050673; GO:0001822; GO:0030324; GO:0072138; GO:0072180; GO:0090090; GO:0008285; GO:0050680; GO:0045926; GO:0010466; GO:0045879; GO:0030316; GO:0030513; GO:0090263; GO:0045807; GO:0046326; GO:0045732; GO:0045880; GO:2000096; GO:0060828; GO:0040008; GO:2000050; GO:1905475; GO:0009966; GO:0009617; GO:0007224; GO:0060071","PTHR10822:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4451|UniProtKB=P51654"]
["GM130",null,"GOLGA2","130","ms",null,4,2,"n/a","n/a","n/a","n/a","# 1963",".APH., .CCP., .CCY., .CD., .CP., .CSP., .OP.",null,"GOLGIN SUBFAMILY A MEMBER 2","asymmetric cell division; cell cycle; cell division; centrosome cycle; endoplasmic reticulum to Golgi vesicle-mediated transport; Golgi disassembly; Golgi organization; Golgi ribbon formation; meiotic spindle assembly; microtubule nucleation; mitotic spindle assembly; negative regulation of autophagy; negative regulation of protein binding; positive regulation of protein glycosylation; protein glycosylation; protein homotetramerization; protein transport; spindle assembly","cadherin binding; identical protein binding; importin-alpha family protein binding; microtubule binding; protein binding; protein kinase binding; syntaxin binding","cis-Golgi network; COPII-coated ER to Golgi transport vesicle; cytoplasm; cytoskeleton; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi apparatus; Golgi cis cisterna; Golgi cisterna membrane; Golgi membrane; membrane; microtubule; mitotic spindle; spindle pole",null,"golgin A2","http://www.ncbi.nlm.nih.gov/gene/?term=2801","2801","99412","64528",null,null,null,"Q08379","Q921M4","Q62839",null,null,"F7GW48","GO:0005801; GO:0030134; GO:0005737; GO:0005856; GO:0033116; GO:0005794; GO:0000137; GO:0032580; GO:0000139; GO:0016020; GO:0005874; GO:0072686; GO:0000922","GO:0045296; GO:0042802; GO:0061676; GO:0008017; GO:0005515; GO:0019901; GO:0019905","GO:0008356; GO:0007049; GO:0051301; GO:0007098; GO:0006888; GO:0090166; GO:0007030; GO:0090161; GO:0090306; GO:0007020; GO:0090307; GO:0010507; GO:0032091; GO:0060050; GO:0006486; GO:0051289; GO:0015031; GO:0051225","PTHR10881:SF58","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4425|UniProtKB=Q08379"]
["GP130",null,"IL6ST","130","rb",null,2.1,2.1,4,4,4,4,"# 0759",".APO., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INT., .NOTCH., .OP., .OPA., .OT., .PLAT., .RTK., .ST., .STAT., .TCD., .TCR., .TMAT., .TRASR.","Interleukin signaling pathway","INTERLEUKIN-6 RECEPTOR SUBUNIT BETA","ciliary neurotrophic factor-mediated signaling pathway; cytokine-mediated signaling pathway; glycogen metabolic process; interleukin-11-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; leukemia inhibitory factor signaling pathway; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; oncostatin-M-mediated signaling pathway; positive regulation of acute inflammatory response; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; positive regulation of cardiac muscle hypertrophy; positive regulation of cell population proliferation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of platelet aggregation; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial growth factor production; regulation of Notch signaling pathway; response to cytokine; signal transduction","ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; cytokine binding; cytokine receptor activity; growth factor binding; identical protein binding; interleukin-11 binding; interleukin-11 receptor activity; interleukin-27 receptor activity; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; protein binding; scaffold protein binding","cell body; ciliary neurotrophic factor receptor complex; dendrite; external side of plasma membrane; extracellular exosome; extracellular region; interleukin-6 receptor complex; membrane; membrane raft; neuronal cell body; oncostatin-M receptor complex; plasma membrane; receptor complex","Jak/Stat signaling","interleukin 6 cytokine family signal transducer","http://www.ncbi.nlm.nih.gov/gene/?term=3572","3572","16195","25205",null,null,null,"P40189","Q00560","A0A8I5Y7Q5","A0A8I3PYQ9","A0A5G2QW91","F7FX67","GO:0044297; GO:0070110; GO:0030425; GO:0009897; GO:0070062; GO:0005576; GO:0005896; GO:0016020; GO:0045121; GO:0043025; GO:0005900; GO:0005886; GO:0043235","GO:0004897; GO:0005127; GO:0019955; GO:0004896; GO:0019838; GO:0042802; GO:0019970; GO:0004921; GO:0045509; GO:0019981; GO:0004915; GO:0005138; GO:0004923; GO:0004924; GO:0005515; GO:0097110","GO:0070120; GO:0019221; GO:0005977; GO:0038154; GO:0070106; GO:0070102; GO:0060576; GO:0048861; GO:0043066; GO:0043524; GO:0038165; GO:0002675; GO:0002821; GO:0048711; GO:0010613; GO:0008284; GO:0045747; GO:0045669; GO:1901731; GO:0042102; GO:0042531; GO:0010575; GO:0008593; GO:0034097; GO:0007165","PTHR23036:SF83","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6021|UniProtKB=P40189","P00036"]
["GPR30",null,"GPER1","38","rb",null,6,1,2,7,2,2,"# 0773",".APO., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .ErbB., .GPCR., .GPROT., .IIR., .IMFR., .IMU., .IMUR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TNF., .TRASR.",null,"G-PROTEIN COUPLED ESTROGEN RECEPTOR 1","adenylate cyclase-activating G protein-coupled receptor signaling pathway; apoptotic chromosome condensation; apoptotic process; cell cycle; cell differentiation; cellular response to estradiol stimulus; cellular response to glucose stimulus; cellular response to mineralocorticoid stimulus; cellular response to peptide hormone stimulus; cellular response to tumor necrosis factor; G protein-coupled receptor signaling pathway; immune system process; inflammatory response; innate immune response; intracellular steroid hormone receptor signaling pathway; modulation of chemical synaptic transmission; negative regulation of cell cycle process; negative regulation of cell population proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of leukocyte activation; negative regulation of lipid biosynthetic process; negative regulation of protein kinase B signaling; negative regulation of vascular associated smooth muscle cell proliferation; nervous system development; neuronal action potential; nuclear fragmentation involved in apoptotic nuclear change; positive regulation of apoptotic process; positive regulation of cardiac vascular smooth muscle cell differentiation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cytosolic calcium ion concentration; positive regulation of endothelial cell apoptotic process; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of gene expression; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of insulin secretion; positive regulation of MAPK cascade; positive regulation of neurogenesis; positive regulation of neurotransmitter secretion; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of release of cytochrome c from mitochondria; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription by RNA polymerase II; positive regulation of uterine smooth muscle contraction; regulation of cell cycle; regulation of cytosolic calcium ion concentration; signal transduction; steroid hormone mediated signaling pathway; vasodilation","chromatin binding; G protein-coupled estrogen receptor activity; G protein-coupled receptor activity; nuclear estrogen receptor activity; protein binding; steroid binding; steroid hormone binding","axon; axon terminus; cell projection; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytoskeleton; cytosol; dendrite; dendritic shaft; dendritic spine head; dendritic spine membrane; early endosome; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; Golgi apparatus; Golgi membrane; hippocampal mossy fiber to CA3 synapse; intracellular membrane-bounded organelle; keratin filament; membrane; mitochondrial membrane; mitochondrion; nuclear envelope; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; presynaptic active zone; presynaptic membrane; recycling endosome; synapse; trans-Golgi network",null,"G protein-coupled estrogen receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=2852","2852","76854","171104","480808","100521003","696625","Q99527","Q8BMP4","G3V654","A0A8P0PQ64","I3LSZ2","F7EQ49","GO:0030424; GO:0043679; GO:0042995; GO:0005737; GO:0031410; GO:0030659; GO:0005856; GO:0005829; GO:0030425; GO:0043198; GO:0044327; GO:0032591; GO:0005769; GO:0005783; GO:0005789; GO:0005768; GO:0005794; GO:0000139; GO:0098686; GO:0043231; GO:0045095; GO:0016020; GO:0031966; GO:0005739; GO:0005635; GO:0005730; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0014069; GO:0048786; GO:0042734; GO:0055037; GO:0045202; GO:0005802","GO:0003682; GO:0038054; GO:0004930; GO:0030284; GO:0005515; GO:0005496; GO:1990239","GO:0007189; GO:0030263; GO:0006915; GO:0007049; GO:0030154; GO:0071392; GO:0071333; GO:0071389; GO:0071375; GO:0071356; GO:0007186; GO:0002376; GO:0006954; GO:0045087; GO:0030518; GO:0050804; GO:0010948; GO:0008285; GO:0070373; GO:0045599; GO:0010629; GO:0050728; GO:0002695; GO:0051055; GO:0051898; GO:1904706; GO:0007399; GO:0019228; GO:0030264; GO:0043065; GO:2000724; GO:0030335; GO:0008284; GO:0043280; GO:0007204; GO:2000353; GO:0045742; GO:0070374; GO:2001238; GO:0045745; GO:0010628; GO:0032962; GO:0032024; GO:0043410; GO:0050769; GO:0001956; GO:0014068; GO:1903078; GO:0001934; GO:0090200; GO:0051281; GO:0045944; GO:0070474; GO:0051726; GO:0051480; GO:0007165; GO:0043401; GO:0042311","PTHR24226:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4485|UniProtKB=Q99527"]
["Gpr49 (LGR5)",null,"LGR5","100","rb",null,7,7,2,2,7,7,"# 0200",".CCP., .CP., .CSP., .DEV., .GPCR., .GPROT., .OP., .OPA., .ST., .WNT.",null,"LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5","epithelial cell proliferation involved in renal tubule morphogenesis; G protein-coupled receptor signaling pathway; hair follicle development; inner ear development; oocyte differentiation; positive regulation of canonical Wnt signaling pathway; regulation of cell population proliferation; signal transduction","G protein-coupled receptor activity; protein binding; protein-hormone receptor activity; transmembrane signaling receptor activity","Golgi apparatus; membrane; nucleoplasm; plasma membrane; trans-Golgi network membrane","Cell-cell interaction","leucine rich repeat containing G protein-coupled receptor 5","http://www.ncbi.nlm.nih.gov/gene/?term=8549","8549","14160","299802",null,"100151994",null,"O75473","Q9Z1P4","D4AC13","A0A8I3PFM6","A0A0H4J9E9","F7BF56","GO:0005794; GO:0016020; GO:0005654; GO:0005886; GO:0032588","GO:0004930; GO:0005515; GO:0016500; GO:0004888","GO:2001013; GO:0007186; GO:0001942; GO:0048839; GO:0009994; GO:0090263; GO:0042127; GO:0007165","PTHR24372:SF71","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4504|UniProtKB=O75473"]
["Gpr49 (LGR5)",null,"LGR5","100","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2106",".CCP., .CP., .CSP., .DEV., .GPCR., .GPROT., .OP., .OPA., .ST., .WNT.",null,"LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5","epithelial cell proliferation involved in renal tubule morphogenesis; G protein-coupled receptor signaling pathway; hair follicle development; inner ear development; oocyte differentiation; positive regulation of canonical Wnt signaling pathway; regulation of cell population proliferation; signal transduction","G protein-coupled receptor activity; protein binding; protein-hormone receptor activity; transmembrane signaling receptor activity","Golgi apparatus; membrane; nucleoplasm; plasma membrane; trans-Golgi network membrane","Metabolism","leucine rich repeat containing G protein-coupled receptor 5","http://www.ncbi.nlm.nih.gov/gene/?term=8549","8549","14160","299802",null,"100151994",null,"O75473","Q9Z1P4","D4AC13","A0A8I3PFM6","A0A0H4J9E9","F7BF56","GO:0005794; GO:0016020; GO:0005654; GO:0005886; GO:0032588","GO:0004930; GO:0005515; GO:0016500; GO:0004888","GO:2001013; GO:0007186; GO:0001942; GO:0048839; GO:0009994; GO:0090263; GO:0042127; GO:0007165","PTHR24372:SF71","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4504|UniProtKB=O75473"]
["GPR55",null,"GPR55","37","rb",null,2,2,2,1,2,2,"# 1617",".CSP., .GPCR., .GPROT., .MAPK., .OPA., .RAS., .RTK., .ST.",null,"G-PROTEIN COUPLED RECEPTOR 55","activation of phospholipase C activity; bone resorption; cannabinoid signaling pathway; G protein-coupled receptor signaling pathway; negative regulation of osteoclast differentiation; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of Rho protein signal transduction; signal transduction","cannabinoid receptor activity; G protein-coupled receptor activity","membrane; plasma membrane","GPCR","G protein-coupled receptor 55","http://www.ncbi.nlm.nih.gov/gene/?term=9290","9290","227326","501177",null,null,null,"Q9Y2T6","Q3UJF0","A0A8I5Y6K3",null,null,null,"GO:0016020; GO:0005886","GO:0004949; GO:0004930","GO:0007202; GO:0045453; GO:0038171; GO:0007186; GO:0045671; GO:0051482; GO:0070374; GO:0035025; GO:0007165","PTHR24232:SF56","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4511|UniProtKB=Q9Y2T6"]
["GPR84",null,"GPR84","44","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1672",".CSP., .GPCR., .GPROT., .OPA., .ST.",null,"G-PROTEIN COUPLED RECEPTOR 84","biological_process; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; signal transduction","G protein-coupled peptide receptor activity; G protein-coupled receptor activity; urotensin II receptor activity","membrane; plasma membrane; receptor complex; specific granule membrane; tertiary granule membrane",null,"G protein-coupled receptor 84","http://www.ncbi.nlm.nih.gov/gene/?term=53831","53831","80910","688730","100687941",null,"705309","Q9NQS5","A0A0R4J100","D4ACK0","A0A8I3P3M6",null,"F6W0J1","GO:0016020; GO:0005886; GO:0043235; GO:0035579; GO:0070821","GO:0008528; GO:0004930; GO:0001604","GO:0008150; GO:0007186; GO:0007218; GO:0007165","PTHR24230:SF59","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4535|UniProtKB=Q9NQS5"]
["GRB10",null,"GRB10","76","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2364",".CSP., .CUR., .D100., .D200., .D300., .DEV., .DMTOR., .INS., .MAPK., .MTOR., .OPA., .RTK., .SREME., .ST., .VEGFS., .WNT.",null,"GROWTH FACTOR RECEPTOR-BOUND PROTEIN 10","ERK1 and ERK2 cascade; gene expression; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; negative regulation of Wnt signaling pathway; positive regulation of cold-induced thermogenesis; positive regulation of vascular endothelial growth factor receptor signaling pathway; signal transduction; vascular associated smooth muscle cell migration","insulin receptor binding; protein binding; protein-macromolecule adaptor activity; signaling receptor complex adaptor activity","cytoplasm; cytosol; plasma membrane; protein-containing complex",null,"growth factor receptor bound protein 10","http://www.ncbi.nlm.nih.gov/gene/?term=2887","2887","14783","498416",null,"100188977","694786","Q13322","Q60760","A0A0G2JYJ1","A0A8I3NBK6","B5KFD7","F7F404","GO:0005737; GO:0005829; GO:0005886; GO:0032991","GO:0005158; GO:0005515; GO:0030674; GO:0030159","GO:0070371; GO:0010467; GO:0008286; GO:0048009; GO:0046325; GO:0046627; GO:0042326; GO:0030178; GO:0120162; GO:0030949; GO:0007165; GO:1904738","PTHR11243:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4564|UniProtKB=Q13322"]
["GRB10",null,"GRB10","60","ms",null,2,8,"n/a","n/a","n/a","n/a","# 3054",".CSP., .DEV., .INS., .MAPK., .MTOR., .OPA., .RTK., .SREME., .ST., .VEGFS., .WNT.",null,"GROWTH FACTOR RECEPTOR-BOUND PROTEIN 10","ERK1 and ERK2 cascade; gene expression; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; negative regulation of Wnt signaling pathway; positive regulation of cold-induced thermogenesis; positive regulation of vascular endothelial growth factor receptor signaling pathway; signal transduction; vascular associated smooth muscle cell migration","insulin receptor binding; protein binding; protein-macromolecule adaptor activity; signaling receptor complex adaptor activity","cytoplasm; cytosol; plasma membrane; protein-containing complex",null,"growth factor receptor bound protein 10","http://www.ncbi.nlm.nih.gov/gene/?term=2887","2887","14783","498416",null,"100188977","694786","Q13322","Q60760","A0A0G2JYJ1","A0A8I3NBK6","B5KFD7","F7F404","GO:0005737; GO:0005829; GO:0005886; GO:0032991","GO:0005158; GO:0005515; GO:0030674; GO:0030159","GO:0070371; GO:0010467; GO:0008286; GO:0048009; GO:0046325; GO:0046627; GO:0042326; GO:0030178; GO:0120162; GO:0030949; GO:0007165; GO:1904738","PTHR11243:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4564|UniProtKB=Q13322"]
["GRB10 - phospho","Ser476","GRB10","80","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2365",".CSP., .CUR., .D100., .D200., .D300., .DEV., .DMTOR., .INS., .MAPK., .MTOR., .OPA., .RTK., .SREME., .ST., .VEGFS., .WNT.",null,"GROWTH FACTOR RECEPTOR-BOUND PROTEIN 10","ERK1 and ERK2 cascade; gene expression; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; negative regulation of Wnt signaling pathway; positive regulation of cold-induced thermogenesis; positive regulation of vascular endothelial growth factor receptor signaling pathway; signal transduction; vascular associated smooth muscle cell migration","insulin receptor binding; protein binding; protein-macromolecule adaptor activity; signaling receptor complex adaptor activity","cytoplasm; cytosol; plasma membrane; protein-containing complex",null,"growth factor receptor bound protein 10","http://www.ncbi.nlm.nih.gov/gene/?term=2887","2887","14783","498416",null,"100188977","694786","Q13322","Q60760","A0A0G2JYJ1","A0A8I3NBK6","B5KFD7","F7F404","GO:0005737; GO:0005829; GO:0005886; GO:0032991","GO:0005158; GO:0005515; GO:0030674; GO:0030159","GO:0070371; GO:0010467; GO:0008286; GO:0048009; GO:0046325; GO:0046627; GO:0042326; GO:0030178; GO:0120162; GO:0030949; GO:0007165; GO:1904738","PTHR11243:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4564|UniProtKB=Q13322"]
["GRB2",null,"GRB2","25","rb",null,1,1,"n/a","n/a","n/a","n/a","# 3057",".AML., .ANG., .BCR., .BRC., .CANCER., .CANPTHW., .CCKR., .CD., .CML., .CRC., .CSP., .DDR., .DI., .EGFR., .EMC., .FGFR., .FOXO., .GLI., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MTOR., .NSCLC., .OP., .OPA., .OXS., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR.","Nicotine pharmacodynamics pathway; CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Dopamine receptor mediated signaling pathway; B cell activation; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; PI3 kinase pathway","GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2","actin cytoskeleton reorganization; aging; anatomical structure formation involved in morphogenesis; B cell receptor signaling pathway; branching involved in labyrinthine layer morphogenesis; cellular response to ionizing radiation; endodermal cell differentiation; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; positive regulation of actin filament polymerization; positive regulation of reactive oxygen species metabolic process; Ras protein signal transduction; receptor internalization; regulation of MAPK cascade; signal transduction; signal transduction in response to DNA damage","enzyme binding; ephrin receptor binding; epidermal growth factor receptor binding; guanyl-nucleotide exchange factor adaptor activity; identical protein binding; insulin receptor substrate binding; molecular function activator activity; neurotrophin TRKA receptor binding; phosphoprotein binding; phosphotyrosine residue binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activator activity; protein-containing complex binding; protein-macromolecule adaptor activity; RNA binding; SH3 domain binding; transmembrane receptor protein tyrosine kinase adaptor activity","cell-cell junction; COP9 signalosome; cytoplasm; cytosol; endosome; extracellular exosome; Golgi apparatus; Grb2-EGFR complex; membrane; nucleolus; nucleoplasm; nucleus; plasma membrane; protein-containing complex; vesicle membrane",null,"growth factor receptor bound protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=2885","2885","14784","81504","483312",null,"702041","P62993","Q60631","P62994","A0A8I3PT69","A0A5G2QG04","G7NGP6","GO:0005911; GO:0008180; GO:0005737; GO:0005829; GO:0005768; GO:0070062; GO:0005794; GO:0070436; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0012506","GO:0019899; GO:0046875; GO:0005154; GO:0005091; GO:0042802; GO:0043560; GO:0140677; GO:0005168; GO:0051219; GO:0001784; GO:0005515; GO:0019904; GO:0019901; GO:0019903; GO:0043539; GO:0044877; GO:0030674; GO:0003723; GO:0017124; GO:0005068","GO:0031532; GO:0007568; GO:0048646; GO:0050853; GO:0060670; GO:0071479; GO:0035987; GO:0007173; GO:0008543; GO:0008286; GO:0048009; GO:0030838; GO:2000379; GO:0007265; GO:0031623; GO:0043408; GO:0007165; GO:0042770","PTHR46037:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4566|UniProtKB=P62993","P06587; P06959; P00053; P00032; P05912; P00010; P00036; P06664; P00021; P04393; P00034; P00047; P00005; P00018; P00031; P00048"]
["Gremlin1",null,"GREM1","21","rb",null,7,2,7,4,4,4,"# 0961",".ANG., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .IMUF., .IMUR., .LMIG., .MAPK., .NFKB., .OP., .OPA., .OT., .RTK., .ST., .TGFB., .TRASR., .WNT.",null,"GREMLIN-1","angiogenesis; animal organ morphogenesis; apoptotic process; cardiac muscle cell differentiation; cardiac muscle cell myoblast differentiation; cell migration involved in sprouting angiogenesis; cell morphogenesis; cell-cell signaling; collagen fibril organization; determination of dorsal identity; embryonic limb morphogenesis; endothelial cell migration; limb development; mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of apoptotic process; negative regulation of BMP signaling pathway; negative regulation of bone mineralization; negative regulation of bone mineralization involved in bone maturation; negative regulation of bone remodeling; negative regulation of bone trabecula formation; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of leukocyte chemotaxis; negative regulation of monocyte chemotaxis; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of osteoclast proliferation; negative regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of angiogenesis; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of protein tyrosine kinase activity; positive regulation of receptor internalization; positive regulation of signaling receptor activity; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; proximal/distal pattern formation; regulation of epithelial to mesenchymal transition; regulation of focal adhesion assembly; regulation of stress-activated MAPK cascade; sequestering of BMP from receptor via BMP binding; signal transduction; signal transduction by p53 class mediator; ureteric bud formation","BMP binding; cytokine activity; morphogen activity; protein binding; protein homodimerization activity; receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; vascular endothelial growth factor receptor 2 binding","cell surface; collagen-containing extracellular matrix; extracellular region; extracellular space",null,"gremlin 1, DAN family BMP antagonist","http://www.ncbi.nlm.nih.gov/gene/?term=26585","26585","23892","50566",null,null,null,"O60565","O70326","O35793","A0A8I3SCY1",null,"A0A5S7WI71","GO:0009986; GO:0062023; GO:0005576; GO:0005615","GO:0036122; GO:0005125; GO:0016015; GO:0005515; GO:0042803; GO:0048018; GO:0030297; GO:0043184","GO:0001525; GO:0009887; GO:0006915; GO:0055007; GO:0060379; GO:0002042; GO:0000902; GO:0007267; GO:0030199; GO:0048263; GO:0030326; GO:0043542; GO:0060173; GO:0003337; GO:0043066; GO:0030514; GO:0030502; GO:1900158; GO:0046851; GO:1900155; GO:0090090; GO:0030308; GO:0032331; GO:0045892; GO:0002689; GO:0090027; GO:0045668; GO:0033689; GO:0090291; GO:0060394; GO:0045766; GO:0090190; GO:0008284; GO:0045893; GO:0051092; GO:1901224; GO:1900086; GO:0061098; GO:0002092; GO:2000273; GO:0051973; GO:0045944; GO:0009954; GO:0010717; GO:0051893; GO:0032872; GO:0038098; GO:0007165; GO:0072331; GO:0060676","PTHR15283:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2001|UniProtKB=O60565"]
["GSK-3 alpha",null,"GSK3A","51","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2469",".APH., .APO., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DMTOR., .GPCR., .GPROT., .IMUR., .INS., .MIG., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR., .UBI., .VIR., .WNT.","Insulin/IGF pathway-protein kinase B signaling cascade; Ras Pathway; PDGF signaling pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway","GLYCOGEN SYNTHASE KINASE-3 ALPHA","aging; carbohydrate metabolic process; cardiac left ventricle morphogenesis; cell migration; cellular response to glucocorticoid stimulus; cellular response to insulin stimulus; cellular response to interleukin-3; cellular response to lithium ion; cellular response to organic cyclic compound; dopamine receptor signaling pathway; excitatory postsynaptic potential; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; glycogen metabolic process; hypermethylation of CpG island; insulin receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of dendrite development; negative regulation of developmental process; negative regulation of glucose import; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate; negative regulation of insulin receptor signaling pathway; negative regulation of signal transduction; negative regulation of TOR signaling; negative regulation of type B pancreatic cell development; negative regulation of UDP-glucose catabolic process; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of amyloid-beta formation; positive regulation of autophagy; positive regulation of gene expression; positive regulation of glycogen (starch) synthase activity; positive regulation of heart contraction; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of neuron apoptotic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein targeting to mitochondrion; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein phosphorylation; regulation of autophagy of mitochondrion; regulation of cellular component organization; regulation of gene expression by genomic imprinting; regulation of neuron projection development; regulation of systemic arterial blood pressure; signal transduction; viral protein processing; Wnt signaling pathway","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase A catalytic subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; signaling receptor binding; tau protein binding; tau-protein kinase activity; transferase activity","apical dendrite; axon; beta-catenin destruction complex; cytoplasm; cytosol; microtubule; mitochondrion; neuronal cell body; nucleus; postsynapse; proximal dendrite",null,"glycogen synthase kinase 3 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=2931","2931",null,null,null,null,null,"P49840",null,null,"A0A8I3MIZ4","A0A286ZZN4",null,"GO:0097440; GO:0030424; GO:0030877; GO:0005737; GO:0005829; GO:0005874; GO:0005739; GO:0043025; GO:0005634; GO:0098794; GO:1990635","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0034236; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0120283; GO:0005102; GO:0048156; GO:0050321; GO:0016740","GO:0007568; GO:0005975; GO:0003214; GO:0016477; GO:0071385; GO:0032869; GO:0036016; GO:0071285; GO:0071407; GO:0007212; GO:0060079; GO:0097191; GO:0097192; GO:0005977; GO:0044027; GO:0008286; GO:0090090; GO:0061052; GO:2000171; GO:0051093; GO:0046325; GO:2000466; GO:0045719; GO:1904227; GO:0046627; GO:0009968; GO:0032007; GO:2000077; GO:0010905; GO:0007399; GO:0018105; GO:0018107; GO:0016310; GO:0071879; GO:0106071; GO:1902004; GO:0010508; GO:0010628; GO:2000467; GO:0045823; GO:1901030; GO:0043525; GO:0033138; GO:0010800; GO:0032436; GO:0045732; GO:1903955; GO:0031398; GO:0045944; GO:0043161; GO:0006468; GO:1903146; GO:0051128; GO:0006349; GO:0010975; GO:0003073; GO:0007165; GO:0019082; GO:0016055","PTHR24057:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4616|UniProtKB=P49840","P00033; P04393; P00047; P00026"]
["GSK3 alpha/beta - phospho","Ser21/Ser9","GSK3A, GSK3B","51, 46","rb",null,1,1,4,4,4,4,"# 1209",".ALZ., .ANG., .APH., .APO., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DMTOR., .EGFR., .EMC., .GPCR., .GPROT., .HHSP., .HIPPO., .IMUF., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .UBI., .VIR., .WNT.","Insulin/IGF pathway-protein kinase B signaling cascade; Ras Pathway; PDGF signaling pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; CCKR signaling map; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Hedgehog signaling pathway; Angiogenesis; PI3 kinase pathway; Wnt signaling pathway","GLYCOGEN SYNTHASE KINASE-3 ALPHA; GLYCOGEN SYNTHASE KINASE-3 BETA","aging; carbohydrate metabolic process; cardiac left ventricle morphogenesis; cell migration; cellular response to glucocorticoid stimulus; cellular response to insulin stimulus; cellular response to interleukin-3; cellular response to lithium ion; cellular response to organic cyclic compound; dopamine receptor signaling pathway; excitatory postsynaptic potential; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; glycogen metabolic process; hypermethylation of CpG island; insulin receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of dendrite development; negative regulation of developmental process; negative regulation of glucose import; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate; negative regulation of insulin receptor signaling pathway; negative regulation of signal transduction; negative regulation of TOR signaling; negative regulation of type B pancreatic cell development; negative regulation of UDP-glucose catabolic process; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of amyloid-beta formation; positive regulation of autophagy; positive regulation of gene expression; positive regulation of glycogen (starch) synthase activity; positive regulation of heart contraction; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of neuron apoptotic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein targeting to mitochondrion; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein phosphorylation; regulation of autophagy of mitochondrion; regulation of cellular component organization; regulation of gene expression by genomic imprinting; regulation of neuron projection development; regulation of systemic arterial blood pressure; signal transduction; viral protein processing; Wnt signaling pathway; beta-catenin destruction complex disassembly; cell differentiation; cellular response to amyloid-beta; cellular response to retinoic acid; circadian rhythm; epithelial to mesenchymal transition; ER overload response; establishment of cell polarity; heart valve development; hippocampus development; intracellular signal transduction; maintenance of cell polarity; negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; negative regulation of dopaminergic neuron differentiation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of gene expression; negative regulation of mesenchymal stem cell differentiation; negative regulation of neuron death; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein acetylation; negative regulation of protein binding; negative regulation of protein localization to nucleus; negative regulation of protein-containing complex assembly; neuron projection development; neuron projection organization; positive regulation of cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of cilium assembly; positive regulation of GTPase activity; positive regulation of mitochondrion organization; positive regulation of neuron death; positive regulation of protein binding; positive regulation of protein export from nucleus; positive regulation of protein localization to centrosome; positive regulation of protein localization to cilium; positive regulation of protein-containing complex assembly; presynaptic modulation of chemical synaptic transmission; protein autophosphorylation; regulation of axon extension; regulation of axonogenesis; regulation of cellular response to heat; regulation of circadian rhythm; regulation of dendrite morphogenesis; regulation of long-term synaptic potentiation; regulation of microtubule anchoring at centrosome; regulation of microtubule cytoskeleton organization; regulation of microtubule-based process; regulation of protein export from nucleus; rhythmic process; superior temporal gyrus development","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase A catalytic subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; signaling receptor binding; tau protein binding; tau-protein kinase activity; transferase activity; beta-catenin binding; dynactin binding; NF-kappaB binding; p53 binding; protease binding; RNA polymerase II-specific DNA-binding transcription factor binding; ubiquitin protein ligase binding","apical dendrite; axon; beta-catenin destruction complex; cytoplasm; cytosol; microtubule; mitochondrion; neuronal cell body; nucleus; postsynapse; proximal dendrite; centrosome; dendrite; glutamatergic synapse; membrane; nucleoplasm; plasma membrane; presynapse; Wnt signalosome","Wnt signaling / metabolism","glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 beta","http://www.ncbi.nlm.nih.gov/gene/?term=2931, http://www.ncbi.nlm.nih.gov/gene/?term=2932","2931, 2932","56637","84027",null,null,"","P49840, P49841","Q9WV60","A0A0G2JSH4","A0A8I3MIZ4, A0A8P0ND25","A0A286ZZN4, A0A5K1UHY0","A0A5F8A1A5","GO:0097440; GO:0030424; GO:0030877; GO:0005737; GO:0005829; GO:0005874; GO:0005739; GO:0043025; GO:0005634; GO:0098794; GO:1990635; GO:0005813; GO:0030425; GO:0098978; GO:0016020; GO:0005654; GO:0005886; GO:0098793; GO:1990909","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0034236; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0120283; GO:0005102; GO:0048156; GO:0050321; GO:0016740; GO:0008013; GO:0034452; GO:0051059; GO:0002039; GO:0002020; GO:0061629; GO:0031625","GO:0007568; GO:0005975; GO:0003214; GO:0016477; GO:0071385; GO:0032869; GO:0036016; GO:0071285; GO:0071407; GO:0007212; GO:0060079; GO:0097191; GO:0097192; GO:0005977; GO:0044027; GO:0008286; GO:0090090; GO:0061052; GO:2000171; GO:0051093; GO:0046325; GO:2000466; GO:0045719; GO:1904227; GO:0046627; GO:0009968; GO:0032007; GO:2000077; GO:0010905; GO:0007399; GO:0018105; GO:0018107; GO:0016310; GO:0071879; GO:0106071; GO:1902004; GO:0010508; GO:0010628; GO:2000467; GO:0045823; GO:1901030; GO:0043525; GO:0033138; GO:0010800; GO:0032436; GO:0045732; GO:1903955; GO:0031398; GO:0045944; GO:0043161; GO:0006468; GO:1903146; GO:0051128; GO:0006349; GO:0010975; GO:0003073; GO:0007165; GO:0019082; GO:0016055; GO:1904886; GO:0030154; GO:1904646; GO:0071300; GO:0007623; GO:0001837; GO:0006983; GO:0030010; GO:0003170; GO:0021766; GO:0035556; GO:0030011; GO:0043066; GO:0070885; GO:1905240; GO:1904339; GO:1902042; GO:0010629; GO:2000740; GO:1901215; GO:0032515; GO:1901984; GO:0032091; GO:1900181; GO:0031333; GO:0031175; GO:0106027; GO:0045597; GO:0001954; GO:0045724; GO:0043547; GO:0010822; GO:1901216; GO:0032092; GO:0046827; GO:1904781; GO:1903566; GO:0031334; GO:0099171; GO:0046777; GO:0030516; GO:0050770; GO:1900034; GO:0042752; GO:0048814; GO:1900271; GO:0150101; GO:0070507; GO:0032886; GO:0046825; GO:0048511; GO:0071109","PTHR24057:SF14; PTHR24057:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4616|UniProtKB=P49840; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4617|UniProtKB=P49841","P00033; P04393; P00047; P00026; P06959; P00036; P06664; P00004; P00012; P00025; P00005; P00048; P00057"]
["GSK3 alpha/beta - phospho","Ser21/Ser9","GSK3A, GSK3B","51, 46","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2790",".ALZ., .ANG., .APH., .APO., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DEV., .DI., .EGFR., .EMC., .GPCR., .GPROT., .HHSP., .HIPPO., .IMUF., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .UBI., .VIR., .WNT.","Insulin/IGF pathway-protein kinase B signaling cascade; Ras Pathway; PDGF signaling pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; CCKR signaling map; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Hedgehog signaling pathway; Angiogenesis; PI3 kinase pathway; Wnt signaling pathway","GLYCOGEN SYNTHASE KINASE-3 ALPHA; GLYCOGEN SYNTHASE KINASE-3 BETA","aging; carbohydrate metabolic process; cardiac left ventricle morphogenesis; cell migration; cellular response to glucocorticoid stimulus; cellular response to insulin stimulus; cellular response to interleukin-3; cellular response to lithium ion; cellular response to organic cyclic compound; dopamine receptor signaling pathway; excitatory postsynaptic potential; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; glycogen metabolic process; hypermethylation of CpG island; insulin receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of dendrite development; negative regulation of developmental process; negative regulation of glucose import; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate; negative regulation of insulin receptor signaling pathway; negative regulation of signal transduction; negative regulation of TOR signaling; negative regulation of type B pancreatic cell development; negative regulation of UDP-glucose catabolic process; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of amyloid-beta formation; positive regulation of autophagy; positive regulation of gene expression; positive regulation of glycogen (starch) synthase activity; positive regulation of heart contraction; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of neuron apoptotic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein targeting to mitochondrion; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein phosphorylation; regulation of autophagy of mitochondrion; regulation of cellular component organization; regulation of gene expression by genomic imprinting; regulation of neuron projection development; regulation of systemic arterial blood pressure; signal transduction; viral protein processing; Wnt signaling pathway; beta-catenin destruction complex disassembly; cell differentiation; cellular response to amyloid-beta; cellular response to retinoic acid; circadian rhythm; epithelial to mesenchymal transition; ER overload response; establishment of cell polarity; heart valve development; hippocampus development; intracellular signal transduction; maintenance of cell polarity; negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; negative regulation of dopaminergic neuron differentiation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of gene expression; negative regulation of mesenchymal stem cell differentiation; negative regulation of neuron death; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein acetylation; negative regulation of protein binding; negative regulation of protein localization to nucleus; negative regulation of protein-containing complex assembly; neuron projection development; neuron projection organization; positive regulation of cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of cilium assembly; positive regulation of GTPase activity; positive regulation of mitochondrion organization; positive regulation of neuron death; positive regulation of protein binding; positive regulation of protein export from nucleus; positive regulation of protein localization to centrosome; positive regulation of protein localization to cilium; positive regulation of protein-containing complex assembly; presynaptic modulation of chemical synaptic transmission; protein autophosphorylation; regulation of axon extension; regulation of axonogenesis; regulation of cellular response to heat; regulation of circadian rhythm; regulation of dendrite morphogenesis; regulation of long-term synaptic potentiation; regulation of microtubule anchoring at centrosome; regulation of microtubule cytoskeleton organization; regulation of microtubule-based process; regulation of protein export from nucleus; rhythmic process; superior temporal gyrus development","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase A catalytic subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; signaling receptor binding; tau protein binding; tau-protein kinase activity; transferase activity; beta-catenin binding; dynactin binding; NF-kappaB binding; p53 binding; protease binding; RNA polymerase II-specific DNA-binding transcription factor binding; ubiquitin protein ligase binding","apical dendrite; axon; beta-catenin destruction complex; cytoplasm; cytosol; microtubule; mitochondrion; neuronal cell body; nucleus; postsynapse; proximal dendrite; centrosome; dendrite; glutamatergic synapse; membrane; nucleoplasm; plasma membrane; presynapse; Wnt signalosome",null,"glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 beta","http://www.ncbi.nlm.nih.gov/gene/?term=2931, http://www.ncbi.nlm.nih.gov/gene/?term=2932","2931, 2932","56637","84027",null,null,"","P49840, P49841","Q9WV60","A0A0G2JSH4","A0A8I3MIZ4, A0A8P0ND25","A0A286ZZN4, A0A5K1UHY0","A0A5F8A1A5","GO:0097440; GO:0030424; GO:0030877; GO:0005737; GO:0005829; GO:0005874; GO:0005739; GO:0043025; GO:0005634; GO:0098794; GO:1990635; GO:0005813; GO:0030425; GO:0098978; GO:0016020; GO:0005654; GO:0005886; GO:0098793; GO:1990909","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0034236; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0120283; GO:0005102; GO:0048156; GO:0050321; GO:0016740; GO:0008013; GO:0034452; GO:0051059; GO:0002039; GO:0002020; GO:0061629; GO:0031625","GO:0007568; GO:0005975; GO:0003214; GO:0016477; GO:0071385; GO:0032869; GO:0036016; GO:0071285; GO:0071407; GO:0007212; GO:0060079; GO:0097191; GO:0097192; GO:0005977; GO:0044027; GO:0008286; GO:0090090; GO:0061052; GO:2000171; GO:0051093; GO:0046325; GO:2000466; GO:0045719; GO:1904227; GO:0046627; GO:0009968; GO:0032007; GO:2000077; GO:0010905; GO:0007399; GO:0018105; GO:0018107; GO:0016310; GO:0071879; GO:0106071; GO:1902004; GO:0010508; GO:0010628; GO:2000467; GO:0045823; GO:1901030; GO:0043525; GO:0033138; GO:0010800; GO:0032436; GO:0045732; GO:1903955; GO:0031398; GO:0045944; GO:0043161; GO:0006468; GO:1903146; GO:0051128; GO:0006349; GO:0010975; GO:0003073; GO:0007165; GO:0019082; GO:0016055; GO:1904886; GO:0030154; GO:1904646; GO:0071300; GO:0007623; GO:0001837; GO:0006983; GO:0030010; GO:0003170; GO:0021766; GO:0035556; GO:0030011; GO:0043066; GO:0070885; GO:1905240; GO:1904339; GO:1902042; GO:0010629; GO:2000740; GO:1901215; GO:0032515; GO:1901984; GO:0032091; GO:1900181; GO:0031333; GO:0031175; GO:0106027; GO:0045597; GO:0001954; GO:0045724; GO:0043547; GO:0010822; GO:1901216; GO:0032092; GO:0046827; GO:1904781; GO:1903566; GO:0031334; GO:0099171; GO:0046777; GO:0030516; GO:0050770; GO:1900034; GO:0042752; GO:0048814; GO:1900271; GO:0150101; GO:0070507; GO:0032886; GO:0046825; GO:0048511; GO:0071109","PTHR24057:SF14; PTHR24057:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4616|UniProtKB=P49840; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4617|UniProtKB=P49841","P00033; P04393; P00047; P00026; P06959; P00036; P06664; P00004; P00012; P00025; P00005; P00048; P00057"]
["GSK3 alpha/beta - phospho","Tyr279/Tyr216","GSK3A, GSK3B","51, 47","rb",null,1,1,8,8,2.1,2.1,"# 2562",".ALZ., .ANG., .APH., .APO., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .EGFR., .EMC., .GPCR., .GPROT., .HHSP., .HIPPO., .IMUF., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .UBI., .VIR., .WNT.","Insulin/IGF pathway-protein kinase B signaling cascade; Ras Pathway; PDGF signaling pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; CCKR signaling map; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Hedgehog signaling pathway; Angiogenesis; PI3 kinase pathway; Wnt signaling pathway","GLYCOGEN SYNTHASE KINASE-3 ALPHA; GLYCOGEN SYNTHASE KINASE-3 BETA","aging; carbohydrate metabolic process; cardiac left ventricle morphogenesis; cell migration; cellular response to glucocorticoid stimulus; cellular response to insulin stimulus; cellular response to interleukin-3; cellular response to lithium ion; cellular response to organic cyclic compound; dopamine receptor signaling pathway; excitatory postsynaptic potential; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; glycogen metabolic process; hypermethylation of CpG island; insulin receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of dendrite development; negative regulation of developmental process; negative regulation of glucose import; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of glycogen synthase activity, transferring glucose-1-phosphate; negative regulation of insulin receptor signaling pathway; negative regulation of signal transduction; negative regulation of TOR signaling; negative regulation of type B pancreatic cell development; negative regulation of UDP-glucose catabolic process; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of amyloid-beta formation; positive regulation of autophagy; positive regulation of gene expression; positive regulation of glycogen (starch) synthase activity; positive regulation of heart contraction; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of neuron apoptotic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein targeting to mitochondrion; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein phosphorylation; regulation of autophagy of mitochondrion; regulation of cellular component organization; regulation of gene expression by genomic imprinting; regulation of neuron projection development; regulation of systemic arterial blood pressure; signal transduction; viral protein processing; Wnt signaling pathway; beta-catenin destruction complex disassembly; cell differentiation; cellular response to amyloid-beta; cellular response to retinoic acid; circadian rhythm; epithelial to mesenchymal transition; ER overload response; establishment of cell polarity; heart valve development; hippocampus development; intracellular signal transduction; maintenance of cell polarity; negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; negative regulation of dopaminergic neuron differentiation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of gene expression; negative regulation of mesenchymal stem cell differentiation; negative regulation of neuron death; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein acetylation; negative regulation of protein binding; negative regulation of protein localization to nucleus; negative regulation of protein-containing complex assembly; neuron projection development; neuron projection organization; positive regulation of cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of cilium assembly; positive regulation of GTPase activity; positive regulation of mitochondrion organization; positive regulation of neuron death; positive regulation of protein binding; positive regulation of protein export from nucleus; positive regulation of protein localization to centrosome; positive regulation of protein localization to cilium; positive regulation of protein-containing complex assembly; presynaptic modulation of chemical synaptic transmission; protein autophosphorylation; regulation of axon extension; regulation of axonogenesis; regulation of cellular response to heat; regulation of circadian rhythm; regulation of dendrite morphogenesis; regulation of long-term synaptic potentiation; regulation of microtubule anchoring at centrosome; regulation of microtubule cytoskeleton organization; regulation of microtubule-based process; regulation of protein export from nucleus; rhythmic process; superior temporal gyrus development","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase A catalytic subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; signaling receptor binding; tau protein binding; tau-protein kinase activity; transferase activity; beta-catenin binding; dynactin binding; NF-kappaB binding; p53 binding; protease binding; RNA polymerase II-specific DNA-binding transcription factor binding; ubiquitin protein ligase binding","apical dendrite; axon; beta-catenin destruction complex; cytoplasm; cytosol; microtubule; mitochondrion; neuronal cell body; nucleus; postsynapse; proximal dendrite; centrosome; dendrite; glutamatergic synapse; membrane; nucleoplasm; plasma membrane; presynapse; Wnt signalosome","Wnt signaling / metabolism","glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 beta","http://www.ncbi.nlm.nih.gov/gene/?term=2931, http://www.ncbi.nlm.nih.gov/gene/?term=2932","2931, 2932","56637","84027",null,null,"","P49840, P49841","Q9WV60","A0A0G2JSH4","A0A8I3MIZ4, A0A8P0ND25","A0A286ZZN4, A0A5K1UHY0","A0A5F8A1A5","GO:0097440; GO:0030424; GO:0030877; GO:0005737; GO:0005829; GO:0005874; GO:0005739; GO:0043025; GO:0005634; GO:0098794; GO:1990635; GO:0005813; GO:0030425; GO:0098978; GO:0016020; GO:0005654; GO:0005886; GO:0098793; GO:1990909","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0034236; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0120283; GO:0005102; GO:0048156; GO:0050321; GO:0016740; GO:0008013; GO:0034452; GO:0051059; GO:0002039; GO:0002020; GO:0061629; GO:0031625","GO:0007568; GO:0005975; GO:0003214; GO:0016477; GO:0071385; GO:0032869; GO:0036016; GO:0071285; GO:0071407; GO:0007212; GO:0060079; GO:0097191; GO:0097192; GO:0005977; GO:0044027; GO:0008286; GO:0090090; GO:0061052; GO:2000171; GO:0051093; GO:0046325; GO:2000466; GO:0045719; GO:1904227; GO:0046627; GO:0009968; GO:0032007; GO:2000077; GO:0010905; GO:0007399; GO:0018105; GO:0018107; GO:0016310; GO:0071879; GO:0106071; GO:1902004; GO:0010508; GO:0010628; GO:2000467; GO:0045823; GO:1901030; GO:0043525; GO:0033138; GO:0010800; GO:0032436; GO:0045732; GO:1903955; GO:0031398; GO:0045944; GO:0043161; GO:0006468; GO:1903146; GO:0051128; GO:0006349; GO:0010975; GO:0003073; GO:0007165; GO:0019082; GO:0016055; GO:1904886; GO:0030154; GO:1904646; GO:0071300; GO:0007623; GO:0001837; GO:0006983; GO:0030010; GO:0003170; GO:0021766; GO:0035556; GO:0030011; GO:0043066; GO:0070885; GO:1905240; GO:1904339; GO:1902042; GO:0010629; GO:2000740; GO:1901215; GO:0032515; GO:1901984; GO:0032091; GO:1900181; GO:0031333; GO:0031175; GO:0106027; GO:0045597; GO:0001954; GO:0045724; GO:0043547; GO:0010822; GO:1901216; GO:0032092; GO:0046827; GO:1904781; GO:1903566; GO:0031334; GO:0099171; GO:0046777; GO:0030516; GO:0050770; GO:1900034; GO:0042752; GO:0048814; GO:1900271; GO:0150101; GO:0070507; GO:0032886; GO:0046825; GO:0048511; GO:0071109","PTHR24057:SF14; PTHR24057:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4616|UniProtKB=P49840; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4617|UniProtKB=P49841","P00033; P04393; P00047; P00026; P06959; P00036; P06664; P00004; P00012; P00025; P00005; P00048; P00057"]
["GSK3 beta",null,"GSK3B","46","rb",null,1,1,1,1,1,1,"# 2558",".ALZ., .ANG., .APH., .APO., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .EGFR., .EMC., .GPCR., .GPROT., .HHSP., .HIPPO., .IMUF., .IMUR., .INS., .INT., .MTOR., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .VIR., .WNT.","CCKR signaling map; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; Ras Pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; PDGF signaling pathway; Hedgehog signaling pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Angiogenesis; PI3 kinase pathway; Wnt signaling pathway","GLYCOGEN SYNTHASE KINASE-3 BETA","beta-catenin destruction complex disassembly; carbohydrate metabolic process; cell differentiation; cellular response to amyloid-beta; cellular response to interleukin-3; cellular response to retinoic acid; circadian rhythm; dopamine receptor signaling pathway; epithelial to mesenchymal transition; ER overload response; establishment of cell polarity; excitatory postsynaptic potential; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; glycogen metabolic process; heart valve development; hippocampus development; insulin receptor signaling pathway; intracellular signal transduction; maintenance of cell polarity; negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; negative regulation of developmental process; negative regulation of dopaminergic neuron differentiation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of gene expression; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of mesenchymal stem cell differentiation; negative regulation of neuron death; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein acetylation; negative regulation of protein binding; negative regulation of protein localization to nucleus; negative regulation of protein-containing complex assembly; negative regulation of signal transduction; negative regulation of type B pancreatic cell development; nervous system development; neuron projection development; neuron projection organization; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of cilium assembly; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of mitochondrion organization; positive regulation of neuron death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein export from nucleus; positive regulation of protein localization to centrosome; positive regulation of protein localization to cilium; positive regulation of protein-containing complex assembly; presynaptic modulation of chemical synaptic transmission; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein phosphorylation; regulation of axon extension; regulation of axonogenesis; regulation of cellular component organization; regulation of cellular response to heat; regulation of circadian rhythm; regulation of dendrite morphogenesis; regulation of long-term synaptic potentiation; regulation of microtubule anchoring at centrosome; regulation of microtubule cytoskeleton organization; regulation of microtubule-based process; regulation of neuron projection development; regulation of protein export from nucleus; rhythmic process; signal transduction; superior temporal gyrus development; viral protein processing; Wnt signaling pathway","ATP binding; beta-catenin binding; dynactin binding; kinase activity; NF-kappaB binding; nucleotide binding; p53 binding; protease binding; protein binding; protein kinase A catalytic subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase II-specific DNA-binding transcription factor binding; tau protein binding; tau-protein kinase activity; transferase activity; ubiquitin protein ligase binding","axon; beta-catenin destruction complex; centrosome; cytoplasm; cytosol; dendrite; glutamatergic synapse; membrane; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; presynapse; Wnt signalosome","Wnt signaling / metabolism","glycogen synthase kinase 3 beta","http://www.ncbi.nlm.nih.gov/gene/?term=2932","2932","56637","84027",null,null,null,"P49841","Q9WV60","A0A0G2JSH4","A0A8P0ND25","A0A5K1UHY0","A0A5F8A1A5","GO:0030424; GO:0030877; GO:0005813; GO:0005737; GO:0005829; GO:0030425; GO:0098978; GO:0016020; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0098793; GO:1990909","GO:0005524; GO:0008013; GO:0034452; GO:0016301; GO:0051059; GO:0000166; GO:0002039; GO:0002020; GO:0005515; GO:0034236; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0061629; GO:0048156; GO:0050321; GO:0016740; GO:0031625","GO:1904886; GO:0005975; GO:0030154; GO:1904646; GO:0036016; GO:0071300; GO:0007623; GO:0007212; GO:0001837; GO:0006983; GO:0030010; GO:0060079; GO:0097191; GO:0097192; GO:0005977; GO:0003170; GO:0021766; GO:0008286; GO:0035556; GO:0030011; GO:0043066; GO:0070885; GO:0090090; GO:1905240; GO:0051093; GO:1904339; GO:1902042; GO:0010629; GO:2000466; GO:0045719; GO:2000740; GO:1901215; GO:0032515; GO:1901984; GO:0032091; GO:1900181; GO:0031333; GO:0009968; GO:2000077; GO:0007399; GO:0031175; GO:0106027; GO:0018105; GO:0018107; GO:0016310; GO:0010508; GO:0045597; GO:0001954; GO:0045724; GO:0010628; GO:0043547; GO:1901030; GO:0010822; GO:1901216; GO:0032436; GO:0032092; GO:0045732; GO:0046827; GO:1904781; GO:1903566; GO:0031334; GO:0099171; GO:0043161; GO:0046777; GO:0006468; GO:0030516; GO:0050770; GO:0051128; GO:1900034; GO:0042752; GO:0048814; GO:1900271; GO:0150101; GO:0070507; GO:0032886; GO:0010975; GO:0046825; GO:0048511; GO:0007165; GO:0071109; GO:0019082; GO:0016055","PTHR24057:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4617|UniProtKB=P49841","P06959; P00036; P00033; P06664; P04393; P00004; P00012; P00047; P00025; P00026; P00005; P00048; P00057"]
["GSK3 beta - phospho","Ser9","GSK3B","46","rb",null,1,1,8,8,8,8,"# 2073",".ALZ., .ANG., .APH., .APO., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .EGFR., .EMC., .GPCR., .GPROT., .HHSP., .HIPPO., .IMUF., .IMUR., .INS., .INT., .MTOR., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .VIR., .WNT.","CCKR signaling map; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; Ras Pathway; Alzheimer disease-presenilin pathway; Cadherin signaling pathway; PDGF signaling pathway; Hedgehog signaling pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Angiogenesis; PI3 kinase pathway; Wnt signaling pathway","GLYCOGEN SYNTHASE KINASE-3 BETA","beta-catenin destruction complex disassembly; carbohydrate metabolic process; cell differentiation; cellular response to amyloid-beta; cellular response to interleukin-3; cellular response to retinoic acid; circadian rhythm; dopamine receptor signaling pathway; epithelial to mesenchymal transition; ER overload response; establishment of cell polarity; excitatory postsynaptic potential; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; glycogen metabolic process; heart valve development; hippocampus development; insulin receptor signaling pathway; intracellular signal transduction; maintenance of cell polarity; negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; negative regulation of developmental process; negative regulation of dopaminergic neuron differentiation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of gene expression; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of mesenchymal stem cell differentiation; negative regulation of neuron death; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein acetylation; negative regulation of protein binding; negative regulation of protein localization to nucleus; negative regulation of protein-containing complex assembly; negative regulation of signal transduction; negative regulation of type B pancreatic cell development; nervous system development; neuron projection development; neuron projection organization; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of cilium assembly; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of mitochondrion organization; positive regulation of neuron death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein export from nucleus; positive regulation of protein localization to centrosome; positive regulation of protein localization to cilium; positive regulation of protein-containing complex assembly; presynaptic modulation of chemical synaptic transmission; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein phosphorylation; regulation of axon extension; regulation of axonogenesis; regulation of cellular component organization; regulation of cellular response to heat; regulation of circadian rhythm; regulation of dendrite morphogenesis; regulation of long-term synaptic potentiation; regulation of microtubule anchoring at centrosome; regulation of microtubule cytoskeleton organization; regulation of microtubule-based process; regulation of neuron projection development; regulation of protein export from nucleus; rhythmic process; signal transduction; superior temporal gyrus development; viral protein processing; Wnt signaling pathway","ATP binding; beta-catenin binding; dynactin binding; kinase activity; NF-kappaB binding; nucleotide binding; p53 binding; protease binding; protein binding; protein kinase A catalytic subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase II-specific DNA-binding transcription factor binding; tau protein binding; tau-protein kinase activity; transferase activity; ubiquitin protein ligase binding","axon; beta-catenin destruction complex; centrosome; cytoplasm; cytosol; dendrite; glutamatergic synapse; membrane; mitochondrion; nucleoplasm; nucleus; plasma membrane; postsynapse; presynapse; Wnt signalosome","Wnt signaling / metabolism","glycogen synthase kinase 3 beta","http://www.ncbi.nlm.nih.gov/gene/?term=2932","2932","56637","84027",null,null,null,"P49841","Q9WV60","A0A0G2JSH4","A0A8P0ND25","A0A5K1UHY0","A0A5F8A1A5","GO:0030424; GO:0030877; GO:0005813; GO:0005737; GO:0005829; GO:0030425; GO:0098978; GO:0016020; GO:0005739; GO:0005654; GO:0005634; GO:0005886; GO:0098794; GO:0098793; GO:1990909","GO:0005524; GO:0008013; GO:0034452; GO:0016301; GO:0051059; GO:0000166; GO:0002039; GO:0002020; GO:0005515; GO:0034236; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0061629; GO:0048156; GO:0050321; GO:0016740; GO:0031625","GO:1904886; GO:0005975; GO:0030154; GO:1904646; GO:0036016; GO:0071300; GO:0007623; GO:0007212; GO:0001837; GO:0006983; GO:0030010; GO:0060079; GO:0097191; GO:0097192; GO:0005977; GO:0003170; GO:0021766; GO:0008286; GO:0035556; GO:0030011; GO:0043066; GO:0070885; GO:0090090; GO:1905240; GO:0051093; GO:1904339; GO:1902042; GO:0010629; GO:2000466; GO:0045719; GO:2000740; GO:1901215; GO:0032515; GO:1901984; GO:0032091; GO:1900181; GO:0031333; GO:0009968; GO:2000077; GO:0007399; GO:0031175; GO:0106027; GO:0018105; GO:0018107; GO:0016310; GO:0010508; GO:0045597; GO:0001954; GO:0045724; GO:0010628; GO:0043547; GO:1901030; GO:0010822; GO:1901216; GO:0032436; GO:0032092; GO:0045732; GO:0046827; GO:1904781; GO:1903566; GO:0031334; GO:0099171; GO:0043161; GO:0046777; GO:0006468; GO:0030516; GO:0050770; GO:0051128; GO:1900034; GO:0042752; GO:0048814; GO:1900271; GO:0150101; GO:0070507; GO:0032886; GO:0010975; GO:0046825; GO:0048511; GO:0007165; GO:0071109; GO:0019082; GO:0016055","PTHR24057:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4617|UniProtKB=P49841","P06959; P00036; P00033; P06664; P04393; P00004; P00012; P00047; P00025; P00026; P00005; P00048; P00057"]
["GSS",null,"GSS","52","rb",null,2,1,1,1,1,1,"# 0937",null,null,"GLUTATHIONE SYNTHETASE","amino acid metabolic process; glutathione biosynthetic process; nervous system development; organonitrogen compound metabolic process; response to cadmium ion; response to oxidative stress","ATP binding; glutathione binding; glutathione synthase activity; identical protein binding; ligase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity","cytosol; extracellular exosome","Oxidative stress","glutathione synthetase","http://www.ncbi.nlm.nih.gov/gene/?term=2937","2937","14854","25458","442962",null,null,"P48637","P51855","P46413","A0A8I3NS50","A0A286ZRS0","A0A1D5R0E7","GO:0005829; GO:0070062","GO:0005524; GO:0043295; GO:0004363; GO:0042802; GO:0016874; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0042803","GO:0006520; GO:0006750; GO:0007399; GO:1901564; GO:0046686; GO:0006979","PTHR11130:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4624|UniProtKB=P48637"]
["GTF3C6",null,"GTF3C6","24","rb",null,2,7,7,7,2,7,"# 0962",".OP., .OT., .TRASR.",null,"GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6","5S class rRNA transcription by RNA polymerase III; transcription by RNA polymerase III; tRNA transcription by RNA polymerase III","DNA binding; protein binding; RNA polymerase III general transcription initiation factor activity","nuclear body; nucleoplasm; nucleus; transcription factor TFIIIC complex",null,"general transcription factor IIIC subunit 6","http://www.ncbi.nlm.nih.gov/gene/?term=112495","112495","67371","361858",null,null,null,"Q969F1","Q9D8P7","B0K037",null,"F1RT07",null,"GO:0016604; GO:0005654; GO:0005634; GO:0000127","GO:0003677; GO:0005515; GO:0000995","GO:0042791; GO:0006383; GO:0042797","PTHR21860:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20872|UniProtKB=Q969F1"]
["HAL (histidine ammonia lyase)",null,"HAL","73","rb",null,2,2,2,2,2,2,"# 1152",null,null,"HISTIDINE AMMONIA-LYASE","histidine catabolic process; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate; histidine metabolic process","ammonia-lyase activity; catalytic activity; histidine ammonia-lyase activity; lyase activity","cytoplasm; cytosol","Amino acid degradation","histidine ammonia-lyase","http://www.ncbi.nlm.nih.gov/gene/?term=3034","3034","15109","29301","475433",null,"712963","P42357","P35492","P21213","A0A8I3Q1B2","A0A286ZND0","F7H197","GO:0005737; GO:0005829","GO:0016841; GO:0003824; GO:0004397; GO:0016829","GO:0006548; GO:0019556; GO:0019557; GO:0006547","PTHR10362:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4806|UniProtKB=P42357"]
["Ha-ras",null,"HRAS","21","rb",null,1,2,"n/a","n/a","n/a","n/a","# 2135",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .EGFR., .EMC., .FGFR., .FOXO., .GLI., .HEPB., .IMU., .IMUF., .IMUR., .INS., .INT., .JNK., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TGFB., .TRASR., .TYR., .VEGFS.","T cell activation; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2","GTPASE HRAS","adipose tissue development; animal organ morphogenesis; cell surface receptor signaling pathway; cellular response to gamma radiation; cellular senescence; chemotaxis; defense response to protozoan; endocytosis; fibroblast proliferation; insulin receptor signaling pathway; intrinsic apoptotic signaling pathway; MAPK cascade; negative regulation of cell population proliferation; negative regulation of gene expression; negative regulation of GTPase activity; negative regulation of neuron apoptotic process; neuron apoptotic process; positive regulation of actin cytoskeleton reorganization; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of miRNA metabolic process; positive regulation of phospholipase C activity; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of ruffle assembly; positive regulation of transcription by RNA polymerase II; positive regulation of type II interferon production; positive regulation of wound healing; Ras protein signal transduction; regulation of cell cycle; regulation of cell population proliferation; regulation of long-term neuronal synaptic plasticity; regulation of MAP kinase activity; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of transcription by RNA polymerase II; signal transduction; small GTPase mediated signal transduction; T cell receptor signaling pathway; T-helper 1 type immune response","G protein activity; GDP binding; GTP binding; GTPase activity; hydrolase activity; nucleotide binding; protein binding; protein C-terminus binding; protein serine/threonine kinase activator activity; protein-membrane adaptor activity","cytoplasm; cytosol; endoplasmic reticulum membrane; glutamatergic synapse; Golgi apparatus; Golgi membrane; GTPase complex; membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane","MAPK signaling","HRas proto-oncogene, GTPase","http://www.ncbi.nlm.nih.gov/gene/?term=3265","3265","15461",null,null,null,"698830","P01112","Q61411","A0A8L2QCK8","A0A8I3Q1I3",null,"F7F5J9","GO:0005737; GO:0005829; GO:0005789; GO:0098978; GO:0005794; GO:0000139; GO:1905360; GO:0016020; GO:0005654; GO:0005634; GO:0048471; GO:0005886","GO:0003925; GO:0019003; GO:0005525; GO:0003924; GO:0016787; GO:0000166; GO:0005515; GO:0008022; GO:0043539; GO:0043495","GO:0060612; GO:0009887; GO:0007166; GO:0071480; GO:0090398; GO:0006935; GO:0042832; GO:0006897; GO:0048144; GO:0008286; GO:0097193; GO:0000165; GO:0008285; GO:0010629; GO:0034260; GO:0043524; GO:0051402; GO:2000251; GO:0030335; GO:0008284; GO:0050679; GO:0070374; GO:0048146; GO:0010628; GO:0043547; GO:0046330; GO:0043406; GO:0043410; GO:2000630; GO:0010863; GO:0001934; GO:0090314; GO:1900029; GO:0045944; GO:0032729; GO:0090303; GO:0007265; GO:0051726; GO:0042127; GO:0048169; GO:0043405; GO:0098696; GO:0006357; GO:0007165; GO:0007264; GO:0050852; GO:0042088","PTHR24070:SF385","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5173|UniProtKB=P01112","P00053; P00052; P00010; P00056; P06664; P00021; P04393; P00034; P00047; P00005; P00018; P00048; P04398"]
["Harmonin",null,"USH1C","62","gt",null,2,7,6,6,8,8,"# 0899",".CCP., .CCY., .OP.",null,"HARMONIN","actin filament bundle assembly; brush border assembly; cell differentiation; equilibrioception; G2/M transition of mitotic cell cycle; inner ear auditory receptor cell differentiation; inner ear morphogenesis; inner ear receptor cell stereocilium organization; parallel actin filament bundle assembly; photoreceptor cell maintenance; protein localization to microvillus; protein-containing complex assembly; regulation of microvillus length; retinal cone cell development; sensory perception of light stimulus; sensory perception of sound","protein binding; spectrin binding","apical part of cell; brush border; cell projection; cilium; cytoplasm; cytoskeleton; cytosol; microvillus; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; stereocilia ankle link complex; stereocilium; stereocilium tip; synapse",null,"USH1 protein network component harmonin","http://www.ncbi.nlm.nih.gov/gene/?term=10083","10083","72088",null,null,null,null,"Q9Y6N9","A0A0R4J0Z8","A0A8I5Y9F7","A0A8I3NW26","A0A286ZT78","F7HFQ8","GO:0045177; GO:0005903; GO:0042995; GO:0005929; GO:0005737; GO:0005856; GO:0005829; GO:0005902; GO:0001917; GO:0001750; GO:0005886; GO:0002142; GO:0032420; GO:0032426; GO:0045202","GO:0005515; GO:0030507","GO:0051017; GO:1904970; GO:0030154; GO:0050957; GO:0000086; GO:0042491; GO:0042472; GO:0060122; GO:0030046; GO:0045494; GO:1904106; GO:0065003; GO:0032532; GO:0046549; GO:0050953; GO:0007605","PTHR23116:SF36","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12597|UniProtKB=Q9Y6N9"]
["HAVCR1",null,"HAVCR1","39","rb",null,1,2,"n/a","n/a","n/a","n/a","# 2108",".IMUR., .OP., .VIR.",null,"HEPATITIS A VIRUS CELLULAR RECEPTOR 1","phagocytosis, engulfment; positive regulation of mast cell activation; viral entry into host cell","phosphatidylserine binding; protein binding; virus receptor activity","cell surface; membrane; motile cilium; plasma membrane",null,"hepatitis A virus cellular receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=26762","26762","210535","287222",null,null,null,"Q96D42","F2Z474","Q5FVR0","A0A8I3MJD3","A0A287BBY1",null,"GO:0009986; GO:0016020; GO:0031514; GO:0005886","GO:0001786; GO:0005515; GO:0001618","GO:0006911; GO:0033005; GO:0046718","PTHR47009:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17866|UniProtKB=Q96D42"]
["HAVCR2 (TIM-3)",null,"HAVCR2","70-45","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2841",".CSP., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OT., .RTK., .TCR., .TOLL., .TRASR.",null,"HEPATITIS A VIRUS CELLULAR RECEPTOR 2","adaptive immune response; cellular response to lipopolysaccharide; defense response to Gram-positive bacterium; immune system process; inflammatory response; innate immune response; macrophage activation involved in immune response; maternal process involved in female pregnancy; natural killer cell tolerance induction; negative regulation of defense response to bacterium; negative regulation of gene expression; negative regulation of granulocyte colony-stimulating factor production; negative regulation of immune response to tumor cell; negative regulation of immunological synapse formation; negative regulation of innate immune response; negative regulation of interferon-alpha production; negative regulation of interleukin-2 production; negative regulation of interleukin-3 production; negative regulation of interleukin-6 production; negative regulation of myeloid dendritic cell activation; negative regulation of natural killer cell activation; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of T cell proliferation; negative regulation of T-helper 1 type immune response; negative regulation of tumor necrosis factor production; negative regulation of type I interferon production; negative regulation of type II interferon production; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of defense response to bacterium; positive regulation of ERK1 and ERK2 cascade; positive regulation of innate immune response; positive regulation of interleukin-1 production; positive regulation of interleukin-4 production; positive regulation of macrophage activation; positive regulation of NIK/NF-kappaB signaling; positive regulation of T cell proliferation; positive regulation of tumor necrosis factor production; positive regulation of type II interferon production; regulation of tolerance induction dependent upon immune response; toll-like receptor 3 signaling pathway; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway","metal ion binding; protein binding","anchoring junction; cell surface; early endosome; immunological synapse; membrane; plasma membrane",null,"hepatitis A virus cellular receptor 2","http://www.ncbi.nlm.nih.gov/gene/?term=84868","84868","171285","363578","479318","100522045",null,"Q8TDQ0","Q8VIM0","P0C0K5","A0A8I3ML68","F1RQD6","F7GB92","GO:0070161; GO:0009986; GO:0005769; GO:0001772; GO:0016020; GO:0005886","GO:0046872; GO:0005515","GO:0002250; GO:0071222; GO:0050830; GO:0002376; GO:0006954; GO:0045087; GO:0002281; GO:0060135; GO:0002519; GO:1900425; GO:0010629; GO:0071656; GO:0002838; GO:2000521; GO:0045824; GO:0032687; GO:0032703; GO:0032712; GO:0032715; GO:0030886; GO:0032815; GO:0002859; GO:0032088; GO:2001189; GO:0042130; GO:0002826; GO:0032720; GO:0032480; GO:0032689; GO:0032722; GO:0001819; GO:1900426; GO:0070374; GO:0045089; GO:0032732; GO:0032753; GO:0043032; GO:1901224; GO:0042102; GO:0032760; GO:0032729; GO:0002652; GO:0034138; GO:0034154; GO:0034162","PTHR15498:SF73","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18437|UniProtKB=Q8TDQ0"]
["HDHD2",null,"HDHD2","29","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1995",null,null,"HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2","biological_process; dephosphorylation","enzyme binding; metal ion binding; phosphatase activity; protein binding","extracellular exosome",null,"haloacid dehalogenase like hydrolase domain containing 2","http://www.ncbi.nlm.nih.gov/gene/?term=84064","84064","76987",null,"480146","100521177","697216","Q9H0R4","Q3UGR5","P85007","A0A8P0SLS9","F1RZX9","H9EV26","GO:0070062","GO:0019899; GO:0046872; GO:0016791; GO:0005515","GO:0008150; GO:0016311","PTHR19288:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=25364|UniProtKB=Q9H0R4"]
["HEF1/NEDD9",null,"NEDD9","115, 105","ms",null,1.1000000000000001,4,1.1000000000000001,4,4,4,"# 0959",".CCP., .CCY., .CP., .CSP., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .ST.",null,"ENHANCER OF FILAMENTATION 1","actin filament bundle assembly; actin filament reorganization; activation of GTPase activity; cell adhesion; cell cycle; cell division; cell migration; cilium disassembly; cytoskeleton organization; integrin-mediated signaling pathway; learning or memory; lymphocyte migration into lymphoid organs; negative regulation of cell migration; positive regulation of cell migration; positive regulation of dendritic spine maintenance; positive regulation of immunological synapse formation; positive regulation of lymphocyte chemotaxis; positive regulation of osteoclast differentiation; positive regulation of protein localization; positive regulation of protein tyrosine kinase activity; positive regulation of substrate adhesion-dependent cell spreading; regulation of actin cytoskeleton organization; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway","protein binding; protein tyrosine kinase binding","anchoring junction; basolateral plasma membrane; cell cortex; cell projection; ciliary basal body; cilium; cytoplasm; cytoskeleton; cytosol; focal adhesion; Golgi apparatus; immunological synapse; lamellipodium; membrane; mitotic spindle; nucleoplasm; nucleus; plasma membrane; spindle; spindle pole",null,"neural precursor cell expressed, developmentally down-regulated 9","http://www.ncbi.nlm.nih.gov/gene/?term=4739","4739","18003","291044","488220","100154178",null,"Q14511","O35177","A0A0G2JZL7","A0A8P0NC68","A0A287A380","A0A1D5Q2T3","GO:0070161; GO:0016323; GO:0005938; GO:0042995; GO:0036064; GO:0005929; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0005794; GO:0001772; GO:0030027; GO:0016020; GO:0072686; GO:0005654; GO:0005634; GO:0005886; GO:0005819; GO:0000922","GO:0005515; GO:1990782","GO:0051017; GO:0090527; GO:0090630; GO:0007155; GO:0007049; GO:0051301; GO:0016477; GO:0061523; GO:0007010; GO:0007229; GO:0007611; GO:0097021; GO:0030336; GO:0030335; GO:1902952; GO:2000522; GO:0140131; GO:0045672; GO:1903829; GO:0061098; GO:1900026; GO:0032956; GO:0007165; GO:0007169","PTHR10654:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7733|UniProtKB=Q14511"]
["HELLS",null,"HELLS","97","rb",null,2,2,8,8,8,8,"# 1070",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .OP., .OPA., .OT., .ST., .TRASR., .WNT.","Wnt signaling pathway","LYMPHOID-SPECIFIC HELICASE","apoptotic process; cell cycle; cell division; cellular response to leukemia inhibitory factor; DNA methylation; DNA methylation-dependent heterochromatin formation; heterochromatin formation; kidney development; lymphocyte proliferation; maintenance of DNA methylation; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway; pericentric heterochromatin formation; urogenital system development","ATP binding; ATP-dependent chromatin remodeler activity; chromatin binding; helicase activity; hydrolase activity; nucleotide binding; protein binding","chromosome, centromeric region; nucleus; pericentric heterochromatin",null,"helicase, lymphoid specific","http://www.ncbi.nlm.nih.gov/gene/?term=3070","3070","15201",null,"486809",null,null,"Q9NRZ9","Q60848","A0A0G2JWX6","A0A8I3PAQ1","A0A5G2QZ18","A0A1D5QQU3","GO:0000775; GO:0005634; GO:0005721","GO:0005524; GO:0140658; GO:0003682; GO:0004386; GO:0016787; GO:0000166; GO:0005515","GO:0006915; GO:0007049; GO:0051301; GO:1990830; GO:0006306; GO:0006346; GO:0031507; GO:0001822; GO:0046651; GO:0010216; GO:0043066; GO:2001243; GO:0031508; GO:0001655","PTHR47161:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4861|UniProtKB=Q9NRZ9","P00057"]
["Her2 (ErbB2)",null,"ERBB2","185","rb",null,2,4,4,4,2.1,4,"# 1063",".ANG., .APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .EMC., .ErbB., .HIF., .IMUF., .MAPK., .NSCLC., .OP., .OPA., .OT., .PAC., .PI3K., .PRC., .RTK., .SREME., .ST., .TCR., .TRASR.","Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2","cell surface receptor signaling pathway; cellular response to epidermal growth factor stimulus; cellular response to growth factor stimulus; enzyme-linked receptor protein signaling pathway; ERBB signaling pathway; ERBB2-EGFR signaling pathway; ERBB2-ERBB3 signaling pathway; ERBB2-ERBB4 signaling pathway; heart development; immature T cell proliferation in thymus; intracellular signal transduction; motor neuron axon guidance; myelination; negative regulation of apoptotic process; negative regulation of immature T cell proliferation in thymus; nervous system development; neurogenesis; neuromuscular junction development; neuron differentiation; neurotransmitter receptor localization to postsynaptic specialization membrane; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of transcription by RNA polymerase I; positive regulation of translation; protein autophosphorylation; protein phosphorylation; regulation of angiogenesis; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of microtubule-based process; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing","ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; RNA polymerase I core binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cell projection; cytoplasm; cytoplasmic vesicle; cytosol; early endosome; endosome; endosome membrane; ERBB3:ERBB2 complex; membrane; myelin sheath; neuromuscular junction; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; presynaptic membrane; receptor complex; ruffle membrane","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=2064","2064","13866",null,null,null,null,"P04626","P70424","F7F923","A0A8I3NBI5","A0A5G2Q7P5","A0A1D5QYY4","GO:0016324; GO:0009925; GO:0016323; GO:0042995; GO:0005737; GO:0031410; GO:0005829; GO:0005769; GO:0005768; GO:0010008; GO:0038143; GO:0016020; GO:0043209; GO:0031594; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0042734; GO:0043235; GO:0032587","GO:0005524; GO:0043125; GO:0019838; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0008022; GO:0046982; GO:0004672; GO:0019903; GO:0004713; GO:0001042; GO:0016740; GO:0004714; GO:0004888","GO:0007166; GO:0071364; GO:0071363; GO:0007167; GO:0038127; GO:0038134; GO:0038133; GO:0038135; GO:0007507; GO:0033080; GO:0035556; GO:0008045; GO:0042552; GO:0043066; GO:0033088; GO:0007399; GO:0022008; GO:0007528; GO:0030182; GO:0099645; GO:0048709; GO:0018108; GO:0007422; GO:0014065; GO:0016310; GO:0045785; GO:0030307; GO:0008284; GO:0050679; GO:0010628; GO:0043547; GO:0033674; GO:0043406; GO:0043410; GO:0001934; GO:0090314; GO:0045943; GO:0045727; GO:0046777; GO:0006468; GO:0045765; GO:0042127; GO:0070372; GO:0032886; GO:0007165; GO:0007169; GO:0042060","PTHR24416:SF137","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3430|UniProtKB=P04626","P00012; P00018"]
["Her2 (ErbB2) - phospho","Tyr1221/Tyr1222","ERBB2","185","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0259",".ANG., .APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .EMC., .ErbB., .HIF., .IMUF., .MAPK., .NSCLC., .OP., .OPA., .OT., .PAC., .PI3K., .PRC., .RTK., .SREME., .ST., .TCR., .TRASR.","Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2","cell surface receptor signaling pathway; cellular response to epidermal growth factor stimulus; cellular response to growth factor stimulus; enzyme-linked receptor protein signaling pathway; ERBB signaling pathway; ERBB2-EGFR signaling pathway; ERBB2-ERBB3 signaling pathway; ERBB2-ERBB4 signaling pathway; heart development; immature T cell proliferation in thymus; intracellular signal transduction; motor neuron axon guidance; myelination; negative regulation of apoptotic process; negative regulation of immature T cell proliferation in thymus; nervous system development; neurogenesis; neuromuscular junction development; neuron differentiation; neurotransmitter receptor localization to postsynaptic specialization membrane; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of transcription by RNA polymerase I; positive regulation of translation; protein autophosphorylation; protein phosphorylation; regulation of angiogenesis; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of microtubule-based process; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing","ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; RNA polymerase I core binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cell projection; cytoplasm; cytoplasmic vesicle; cytosol; early endosome; endosome; endosome membrane; ERBB3:ERBB2 complex; membrane; myelin sheath; neuromuscular junction; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; presynaptic membrane; receptor complex; ruffle membrane","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=2064","2064","13866",null,null,null,null,"P04626","P70424","F7F923","A0A8I3NBI5","A0A5G2Q7P5","A0A1D5QYY4","GO:0016324; GO:0009925; GO:0016323; GO:0042995; GO:0005737; GO:0031410; GO:0005829; GO:0005769; GO:0005768; GO:0010008; GO:0038143; GO:0016020; GO:0043209; GO:0031594; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0042734; GO:0043235; GO:0032587","GO:0005524; GO:0043125; GO:0019838; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0008022; GO:0046982; GO:0004672; GO:0019903; GO:0004713; GO:0001042; GO:0016740; GO:0004714; GO:0004888","GO:0007166; GO:0071364; GO:0071363; GO:0007167; GO:0038127; GO:0038134; GO:0038133; GO:0038135; GO:0007507; GO:0033080; GO:0035556; GO:0008045; GO:0042552; GO:0043066; GO:0033088; GO:0007399; GO:0022008; GO:0007528; GO:0030182; GO:0099645; GO:0048709; GO:0018108; GO:0007422; GO:0014065; GO:0016310; GO:0045785; GO:0030307; GO:0008284; GO:0050679; GO:0010628; GO:0043547; GO:0033674; GO:0043406; GO:0043410; GO:0001934; GO:0090314; GO:0045943; GO:0045727; GO:0046777; GO:0006468; GO:0045765; GO:0042127; GO:0070372; GO:0032886; GO:0007165; GO:0007169; GO:0042060","PTHR24416:SF137","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3430|UniProtKB=P04626","P00012; P00018"]
["Her2 (ErbB2) - phospho","Tyr1248","ERBB2","185","rb",null,2.1,2,7,7,2,2,"BG/MP # 129",".ANG., .APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .EMC., .ErbB., .HIF., .IMUF., .MAPK., .NSCLC., .OP., .OPA., .OT., .PAC., .PI3K., .PRC., .RTK., .SREME., .ST., .TCR., .TRASR.","Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2","cell surface receptor signaling pathway; cellular response to epidermal growth factor stimulus; cellular response to growth factor stimulus; enzyme-linked receptor protein signaling pathway; ERBB signaling pathway; ERBB2-EGFR signaling pathway; ERBB2-ERBB3 signaling pathway; ERBB2-ERBB4 signaling pathway; heart development; immature T cell proliferation in thymus; intracellular signal transduction; motor neuron axon guidance; myelination; negative regulation of apoptotic process; negative regulation of immature T cell proliferation in thymus; nervous system development; neurogenesis; neuromuscular junction development; neuron differentiation; neurotransmitter receptor localization to postsynaptic specialization membrane; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of transcription by RNA polymerase I; positive regulation of translation; protein autophosphorylation; protein phosphorylation; regulation of angiogenesis; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of microtubule-based process; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing","ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; RNA polymerase I core binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cell projection; cytoplasm; cytoplasmic vesicle; cytosol; early endosome; endosome; endosome membrane; ERBB3:ERBB2 complex; membrane; myelin sheath; neuromuscular junction; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; presynaptic membrane; receptor complex; ruffle membrane","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=2064","2064","13866",null,null,null,null,"P04626","P70424","F7F923","A0A8I3NBI5","A0A5G2Q7P5","A0A1D5QYY4","GO:0016324; GO:0009925; GO:0016323; GO:0042995; GO:0005737; GO:0031410; GO:0005829; GO:0005769; GO:0005768; GO:0010008; GO:0038143; GO:0016020; GO:0043209; GO:0031594; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0042734; GO:0043235; GO:0032587","GO:0005524; GO:0043125; GO:0019838; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0008022; GO:0046982; GO:0004672; GO:0019903; GO:0004713; GO:0001042; GO:0016740; GO:0004714; GO:0004888","GO:0007166; GO:0071364; GO:0071363; GO:0007167; GO:0038127; GO:0038134; GO:0038133; GO:0038135; GO:0007507; GO:0033080; GO:0035556; GO:0008045; GO:0042552; GO:0043066; GO:0033088; GO:0007399; GO:0022008; GO:0007528; GO:0030182; GO:0099645; GO:0048709; GO:0018108; GO:0007422; GO:0014065; GO:0016310; GO:0045785; GO:0030307; GO:0008284; GO:0050679; GO:0010628; GO:0043547; GO:0033674; GO:0043406; GO:0043410; GO:0001934; GO:0090314; GO:0045943; GO:0045727; GO:0046777; GO:0006468; GO:0045765; GO:0042127; GO:0070372; GO:0032886; GO:0007165; GO:0007169; GO:0042060","PTHR24416:SF137","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3430|UniProtKB=P04626","P00012; P00018"]
["Her2 (ErbB2) - phospho","Tyr877","ERBB2","185","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0286",".ANG., .APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .EGFR., .EMC., .ErbB., .HIF., .IMUF., .MAPK., .NSCLC., .OP., .OPA., .OT., .PAC., .PI3K., .PRC., .RTK., .SREME., .ST., .TCR., .TRASR.","Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2","cell surface receptor signaling pathway; cellular response to epidermal growth factor stimulus; cellular response to growth factor stimulus; enzyme-linked receptor protein signaling pathway; ERBB signaling pathway; ERBB2-EGFR signaling pathway; ERBB2-ERBB3 signaling pathway; ERBB2-ERBB4 signaling pathway; heart development; immature T cell proliferation in thymus; intracellular signal transduction; motor neuron axon guidance; myelination; negative regulation of apoptotic process; negative regulation of immature T cell proliferation in thymus; nervous system development; neurogenesis; neuromuscular junction development; neuron differentiation; neurotransmitter receptor localization to postsynaptic specialization membrane; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of transcription by RNA polymerase I; positive regulation of translation; protein autophosphorylation; protein phosphorylation; regulation of angiogenesis; regulation of cell population proliferation; regulation of ERK1 and ERK2 cascade; regulation of microtubule-based process; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing","ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; RNA polymerase I core binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cell projection; cytoplasm; cytoplasmic vesicle; cytosol; early endosome; endosome; endosome membrane; ERBB3:ERBB2 complex; membrane; myelin sheath; neuromuscular junction; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane region; presynaptic membrane; receptor complex; ruffle membrane","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=2064","2064","13866",null,null,null,null,"P04626","P70424","F7F923","A0A8I3NBI5","A0A5G2Q7P5","A0A1D5QYY4","GO:0016324; GO:0009925; GO:0016323; GO:0042995; GO:0005737; GO:0031410; GO:0005829; GO:0005769; GO:0005768; GO:0010008; GO:0038143; GO:0016020; GO:0043209; GO:0031594; GO:0005634; GO:0048471; GO:0005886; GO:0098590; GO:0042734; GO:0043235; GO:0032587","GO:0005524; GO:0043125; GO:0019838; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0008022; GO:0046982; GO:0004672; GO:0019903; GO:0004713; GO:0001042; GO:0016740; GO:0004714; GO:0004888","GO:0007166; GO:0071364; GO:0071363; GO:0007167; GO:0038127; GO:0038134; GO:0038133; GO:0038135; GO:0007507; GO:0033080; GO:0035556; GO:0008045; GO:0042552; GO:0043066; GO:0033088; GO:0007399; GO:0022008; GO:0007528; GO:0030182; GO:0099645; GO:0048709; GO:0018108; GO:0007422; GO:0014065; GO:0016310; GO:0045785; GO:0030307; GO:0008284; GO:0050679; GO:0010628; GO:0043547; GO:0033674; GO:0043406; GO:0043410; GO:0001934; GO:0090314; GO:0045943; GO:0045727; GO:0046777; GO:0006468; GO:0045765; GO:0042127; GO:0070372; GO:0032886; GO:0007165; GO:0007169; GO:0042060","PTHR24416:SF137","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3430|UniProtKB=P04626","P00012; P00018"]
["Her3 (ErbB3)",null,"ERBB3","150","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1074",".APO., .CADH., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .ErbB., .MAPK., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","cell surface receptor signaling pathway; cranial nerve development; endocardial cushion development; ERBB2-ERBB3 signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; heart development; motor neuron apoptotic process; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of motor neuron apoptotic process; negative regulation of neuron apoptotic process; negative regulation of secretion; negative regulation of signal transduction; neurogenesis; neuron apoptotic process; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle tissue development; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein tyrosine kinase activity; protein phosphorylation; regulation of cell population proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing","ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; neuregulin binding; neuregulin receptor activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; signaling receptor activity; transferase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; ERBB3:ERBB2 complex; extracellular region; extracellular space; lateral plasma membrane; membrane; plasma membrane; plasma membrane region; receptor complex","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=2065","2065","13867",null,null,null,null,"P21860","Q61526","A0A8I5ZUD5","A0A8P0S620","A0A286ZMT1","F7HL92","GO:0016324; GO:0009925; GO:0016323; GO:0038143; GO:0005576; GO:0005615; GO:0016328; GO:0016020; GO:0005886; GO:0098590; GO:0043235","GO:0005524; GO:0043125; GO:0019838; GO:0042802; GO:0016301; GO:0038132; GO:0038131; GO:0000166; GO:0005515; GO:0046982; GO:0004672; GO:0030296; GO:0004713; GO:0038023; GO:0016740; GO:0004888; GO:0031625","GO:0007166; GO:0021545; GO:0003197; GO:0038133; GO:0097192; GO:0007507; GO:0097049; GO:0043066; GO:0007162; GO:2000672; GO:0043524; GO:0051048; GO:0009968; GO:0022008; GO:0051402; GO:0007422; GO:0014065; GO:0016310; GO:0070886; GO:0055025; GO:0008284; GO:0010628; GO:0033674; GO:0014068; GO:0061098; GO:0006468; GO:0042127; GO:0014037; GO:0007165; GO:0007169; GO:0042060","PTHR24416:SF88","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3431|UniProtKB=P21860","P00012; P00018"]
["Her3 (ErbB3)",null,"ERBB3","148","rb",null,4,7,"n/a","n/a","n/a","n/a","# 1076",".APO., .CADH., .CCP., .CD., .CP., .CSP., .EGFR., .ErbB., .MAPK., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","cell surface receptor signaling pathway; cranial nerve development; endocardial cushion development; ERBB2-ERBB3 signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; heart development; motor neuron apoptotic process; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of motor neuron apoptotic process; negative regulation of neuron apoptotic process; negative regulation of secretion; negative regulation of signal transduction; neurogenesis; neuron apoptotic process; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle tissue development; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein tyrosine kinase activity; protein phosphorylation; regulation of cell population proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing","ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; neuregulin binding; neuregulin receptor activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; signaling receptor activity; transferase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; ERBB3:ERBB2 complex; extracellular region; extracellular space; lateral plasma membrane; membrane; plasma membrane; plasma membrane region; receptor complex","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=2065","2065","13867",null,null,null,null,"P21860","Q61526","A0A8I5ZUD5","A0A8P0S620","A0A286ZMT1","F7HL92","GO:0016324; GO:0009925; GO:0016323; GO:0038143; GO:0005576; GO:0005615; GO:0016328; GO:0016020; GO:0005886; GO:0098590; GO:0043235","GO:0005524; GO:0043125; GO:0019838; GO:0042802; GO:0016301; GO:0038132; GO:0038131; GO:0000166; GO:0005515; GO:0046982; GO:0004672; GO:0030296; GO:0004713; GO:0038023; GO:0016740; GO:0004888; GO:0031625","GO:0007166; GO:0021545; GO:0003197; GO:0038133; GO:0097192; GO:0007507; GO:0097049; GO:0043066; GO:0007162; GO:2000672; GO:0043524; GO:0051048; GO:0009968; GO:0022008; GO:0051402; GO:0007422; GO:0014065; GO:0016310; GO:0070886; GO:0055025; GO:0008284; GO:0010628; GO:0033674; GO:0014068; GO:0061098; GO:0006468; GO:0042127; GO:0014037; GO:0007165; GO:0007169; GO:0042060","PTHR24416:SF88","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3431|UniProtKB=P21860","P00012; P00018"]
["Her3 (ErbB3)",null,"ERBB3","185","rb",null,2,1,"n/a","n/a","n/a","n/a","# 2850",".APO., .CADH., .CCP., .CD., .CP., .CSP., .EGFR., .ErbB., .MAPK., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","cell surface receptor signaling pathway; cranial nerve development; endocardial cushion development; ERBB2-ERBB3 signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; heart development; motor neuron apoptotic process; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of motor neuron apoptotic process; negative regulation of neuron apoptotic process; negative regulation of secretion; negative regulation of signal transduction; neurogenesis; neuron apoptotic process; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle tissue development; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein tyrosine kinase activity; protein phosphorylation; regulation of cell population proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing","ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; neuregulin binding; neuregulin receptor activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; signaling receptor activity; transferase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; ERBB3:ERBB2 complex; extracellular region; extracellular space; lateral plasma membrane; membrane; plasma membrane; plasma membrane region; receptor complex","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=2065","2065","13867",null,null,null,null,"P21860","Q61526","A0A8I5ZUD5","A0A8P0S620","A0A286ZMT1","F7HL92","GO:0016324; GO:0009925; GO:0016323; GO:0038143; GO:0005576; GO:0005615; GO:0016328; GO:0016020; GO:0005886; GO:0098590; GO:0043235","GO:0005524; GO:0043125; GO:0019838; GO:0042802; GO:0016301; GO:0038132; GO:0038131; GO:0000166; GO:0005515; GO:0046982; GO:0004672; GO:0030296; GO:0004713; GO:0038023; GO:0016740; GO:0004888; GO:0031625","GO:0007166; GO:0021545; GO:0003197; GO:0038133; GO:0097192; GO:0007507; GO:0097049; GO:0043066; GO:0007162; GO:2000672; GO:0043524; GO:0051048; GO:0009968; GO:0022008; GO:0051402; GO:0007422; GO:0014065; GO:0016310; GO:0070886; GO:0055025; GO:0008284; GO:0010628; GO:0033674; GO:0014068; GO:0061098; GO:0006468; GO:0042127; GO:0014037; GO:0007165; GO:0007169; GO:0042060","PTHR24416:SF88","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3431|UniProtKB=P21860","P00012; P00018"]
["Her3 (ErbB3) - phospho","Tyr1289","ERBB3","185","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0753",".APO., .CADH., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .ErbB., .MAPK., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","cell surface receptor signaling pathway; cranial nerve development; endocardial cushion development; ERBB2-ERBB3 signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; heart development; motor neuron apoptotic process; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of motor neuron apoptotic process; negative regulation of neuron apoptotic process; negative regulation of secretion; negative regulation of signal transduction; neurogenesis; neuron apoptotic process; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle tissue development; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein tyrosine kinase activity; protein phosphorylation; regulation of cell population proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing","ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; neuregulin binding; neuregulin receptor activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; signaling receptor activity; transferase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; ERBB3:ERBB2 complex; extracellular region; extracellular space; lateral plasma membrane; membrane; plasma membrane; plasma membrane region; receptor complex","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=2065","2065","13867",null,null,null,null,"P21860","Q61526","A0A8I5ZUD5","A0A8P0S620","A0A286ZMT1","F7HL92","GO:0016324; GO:0009925; GO:0016323; GO:0038143; GO:0005576; GO:0005615; GO:0016328; GO:0016020; GO:0005886; GO:0098590; GO:0043235","GO:0005524; GO:0043125; GO:0019838; GO:0042802; GO:0016301; GO:0038132; GO:0038131; GO:0000166; GO:0005515; GO:0046982; GO:0004672; GO:0030296; GO:0004713; GO:0038023; GO:0016740; GO:0004888; GO:0031625","GO:0007166; GO:0021545; GO:0003197; GO:0038133; GO:0097192; GO:0007507; GO:0097049; GO:0043066; GO:0007162; GO:2000672; GO:0043524; GO:0051048; GO:0009968; GO:0022008; GO:0051402; GO:0007422; GO:0014065; GO:0016310; GO:0070886; GO:0055025; GO:0008284; GO:0010628; GO:0033674; GO:0014068; GO:0061098; GO:0006468; GO:0042127; GO:0014037; GO:0007165; GO:0007169; GO:0042060","PTHR24416:SF88","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3431|UniProtKB=P21860","P00012; P00018"]
["Her3 (ErbB3) - phospho","Tyr1289","ERBB3","185","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2275",".APO., .CADH., .CCP., .CD., .CP., .CSP., .EGFR., .ErbB., .MAPK., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","cell surface receptor signaling pathway; cranial nerve development; endocardial cushion development; ERBB2-ERBB3 signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; heart development; motor neuron apoptotic process; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of motor neuron apoptotic process; negative regulation of neuron apoptotic process; negative regulation of secretion; negative regulation of signal transduction; neurogenesis; neuron apoptotic process; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle tissue development; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein tyrosine kinase activity; protein phosphorylation; regulation of cell population proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing","ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; neuregulin binding; neuregulin receptor activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; signaling receptor activity; transferase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; ERBB3:ERBB2 complex; extracellular region; extracellular space; lateral plasma membrane; membrane; plasma membrane; plasma membrane region; receptor complex","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=2065","2065","13867",null,null,null,null,"P21860","Q61526","A0A8I5ZUD5","A0A8P0S620","A0A286ZMT1","F7HL92","GO:0016324; GO:0009925; GO:0016323; GO:0038143; GO:0005576; GO:0005615; GO:0016328; GO:0016020; GO:0005886; GO:0098590; GO:0043235","GO:0005524; GO:0043125; GO:0019838; GO:0042802; GO:0016301; GO:0038132; GO:0038131; GO:0000166; GO:0005515; GO:0046982; GO:0004672; GO:0030296; GO:0004713; GO:0038023; GO:0016740; GO:0004888; GO:0031625","GO:0007166; GO:0021545; GO:0003197; GO:0038133; GO:0097192; GO:0007507; GO:0097049; GO:0043066; GO:0007162; GO:2000672; GO:0043524; GO:0051048; GO:0009968; GO:0022008; GO:0051402; GO:0007422; GO:0014065; GO:0016310; GO:0070886; GO:0055025; GO:0008284; GO:0010628; GO:0033674; GO:0014068; GO:0061098; GO:0006468; GO:0042127; GO:0014037; GO:0007165; GO:0007169; GO:0042060","PTHR24416:SF88","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3431|UniProtKB=P21860","P00012; P00018"]
["Her4 (ErbB4)",null,"ERBB4","146","rb",null,2,7,6,7,7,7,"# 1075",".ALZ., .APO., .CADH., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DI., .DRAS., .EGFR., .ErbB., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .STAT., .TRASR.","Alzheimer disease-presenilin pathway; Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4","apoptotic process; cardiac muscle tissue regeneration; cell fate commitment; cell migration; cell surface receptor signaling pathway; cellular response to epidermal growth factor stimulus; central nervous system morphogenesis; embryonic pattern specification; epidermal growth factor receptor signaling pathway; ERBB signaling pathway; ERBB2-ERBB4 signaling pathway; ERBB4 signaling pathway; ERBB4-ERBB4 signaling pathway; establishment of planar polarity involved in nephron morphogenesis; heart development; lactation; mammary gland alveolus development; mammary gland epithelial cell differentiation; mitochondrial fragmentation involved in apoptotic process; negative regulation of apoptotic process; negative regulation of cell population proliferation; nervous system development; neural crest cell migration; neurogenesis; neurotransmitter receptor localization to postsynaptic specialization membrane; olfactory bulb interneuron differentiation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein localization to cell surface; positive regulation of protein phosphorylation; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of tyrosine phosphorylation of STAT protein; protein autophosphorylation; protein phosphorylation; regulation of cell migration; regulation of cell population proliferation; signal transduction; synapse assembly; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; epidermal growth factor receptor activity; epidermal growth factor receptor binding; GABA receptor binding; kinase activity; neuregulin receptor activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transcription cis-regulatory region binding; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; basolateral plasma membrane; cytosol; extracellular region; GABA-ergic synapse; glutamatergic synapse; membrane; mitochondrial matrix; mitochondrion; neuromuscular junction; nucleoplasm; nucleus; plasma membrane; plasma membrane region; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; receptor complex","Tyrosine kinase / adaptor / protooncogene","erb-b2 receptor tyrosine kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=2066","2066","13869",null,null,null,null,"Q15303","Q61527","A0A8I6AGX1","A0A8I3P422","A0A286ZJD5","A0A1D5R123","GO:0009925; GO:0016323; GO:0005829; GO:0005576; GO:0098982; GO:0098978; GO:0016020; GO:0005759; GO:0005739; GO:0031594; GO:0005654; GO:0005634; GO:0005886; GO:0098590; GO:0098839; GO:0045211; GO:0042734; GO:0043235","GO:0005524; GO:0005006; GO:0005154; GO:0050811; GO:0016301; GO:0038131; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0030296; GO:0004713; GO:0000976; GO:0016740; GO:0004714","GO:0006915; GO:0061026; GO:0045165; GO:0016477; GO:0007166; GO:0071364; GO:0021551; GO:0009880; GO:0007173; GO:0038127; GO:0038135; GO:0038130; GO:0038138; GO:0072046; GO:0007507; GO:0007595; GO:0060749; GO:0060644; GO:0043653; GO:0043066; GO:0008285; GO:0007399; GO:0001755; GO:0022008; GO:0099645; GO:0021889; GO:0018108; GO:0016310; GO:0060045; GO:0008284; GO:0045893; GO:0070374; GO:0033674; GO:0014068; GO:2000010; GO:0001934; GO:0046427; GO:0042531; GO:0046777; GO:0006468; GO:0030334; GO:0042127; GO:0007165; GO:0007416; GO:0007169","PTHR24416:SF90","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3432|UniProtKB=Q15303","P00004; P00012; P00018"]
["Her4 (ErbB4) - phospho","Tyr1284","ERBB4","180","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2277",".ALZ., .APO., .CADH., .CCP., .CD., .CP., .CSP., .DI., .EGFR., .ErbB., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .STAT., .TRASR.","Alzheimer disease-presenilin pathway; Cadherin signaling pathway; EGF receptor signaling pathway","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4","apoptotic process; cardiac muscle tissue regeneration; cell fate commitment; cell migration; cell surface receptor signaling pathway; cellular response to epidermal growth factor stimulus; central nervous system morphogenesis; embryonic pattern specification; epidermal growth factor receptor signaling pathway; ERBB signaling pathway; ERBB2-ERBB4 signaling pathway; ERBB4 signaling pathway; ERBB4-ERBB4 signaling pathway; establishment of planar polarity involved in nephron morphogenesis; heart development; lactation; mammary gland alveolus development; mammary gland epithelial cell differentiation; mitochondrial fragmentation involved in apoptotic process; negative regulation of apoptotic process; negative regulation of cell population proliferation; nervous system development; neural crest cell migration; neurogenesis; neurotransmitter receptor localization to postsynaptic specialization membrane; olfactory bulb interneuron differentiation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein localization to cell surface; positive regulation of protein phosphorylation; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of tyrosine phosphorylation of STAT protein; protein autophosphorylation; protein phosphorylation; regulation of cell migration; regulation of cell population proliferation; signal transduction; synapse assembly; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; epidermal growth factor receptor activity; epidermal growth factor receptor binding; GABA receptor binding; kinase activity; neuregulin receptor activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; transcription cis-regulatory region binding; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; basolateral plasma membrane; cytosol; extracellular region; GABA-ergic synapse; glutamatergic synapse; membrane; mitochondrial matrix; mitochondrion; neuromuscular junction; nucleoplasm; nucleus; plasma membrane; plasma membrane region; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; receptor complex",null,"erb-b2 receptor tyrosine kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=2066","2066","13869",null,null,null,null,"Q15303","Q61527","A0A8I6AGX1","A0A8I3P422","A0A286ZJD5","A0A1D5R123","GO:0009925; GO:0016323; GO:0005829; GO:0005576; GO:0098982; GO:0098978; GO:0016020; GO:0005759; GO:0005739; GO:0031594; GO:0005654; GO:0005634; GO:0005886; GO:0098590; GO:0098839; GO:0045211; GO:0042734; GO:0043235","GO:0005524; GO:0005006; GO:0005154; GO:0050811; GO:0016301; GO:0038131; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0030296; GO:0004713; GO:0000976; GO:0016740; GO:0004714","GO:0006915; GO:0061026; GO:0045165; GO:0016477; GO:0007166; GO:0071364; GO:0021551; GO:0009880; GO:0007173; GO:0038127; GO:0038135; GO:0038130; GO:0038138; GO:0072046; GO:0007507; GO:0007595; GO:0060749; GO:0060644; GO:0043653; GO:0043066; GO:0008285; GO:0007399; GO:0001755; GO:0022008; GO:0099645; GO:0021889; GO:0018108; GO:0016310; GO:0060045; GO:0008284; GO:0045893; GO:0070374; GO:0033674; GO:0014068; GO:2000010; GO:0001934; GO:0046427; GO:0042531; GO:0046777; GO:0006468; GO:0030334; GO:0042127; GO:0007165; GO:0007416; GO:0007169","PTHR24416:SF90","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3432|UniProtKB=Q15303","P00004; P00012; P00018"]
["HES-1",null,"HES1","30","rb",null,2,1,2,2,3,3,"# 0933",".BMP., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HHSP., .IMUF., .MIG., .NOTCH., .OP., .OPA., .OT., .RTK., .ST., .STAT., .TCR., .TD., .TMAT., .TNF., .TRASR.","Notch signaling pathway","TRANSCRIPTION FACTOR HES-1","adenohypophysis development; amacrine cell differentiation; anterior/posterior pattern specification; aorta morphogenesis; artery morphogenesis; ascending aorta morphogenesis; BMP signaling pathway; Cajal-Retzius cell differentiation; cardiac neural crest cell development involved in outflow tract morphogenesis; cell adhesion; cell fate commitment; cell fate determination; cell maturation; cell migration; cell morphogenesis involved in neuron differentiation; cell population proliferation; cellular response to fatty acid; cellular response to interleukin-1; cellular response to nerve growth factor stimulus; cellular response to tumor necrosis factor; cochlea development; comma-shaped body morphogenesis; common bile duct development; embryonic heart tube morphogenesis; enteroendocrine cell differentiation; establishment of epithelial cell polarity; forebrain radial glial cell differentiation; glomerulus vasculature development; hair cell differentiation; hindbrain morphogenesis; in utero embryonic development; inhibition of neuroepithelial cell differentiation; inner ear auditory receptor cell differentiation; inner ear receptor cell stereocilium organization; labyrinthine layer blood vessel development; lateral inhibition; liver development; lung development; metanephric nephron tubule morphogenesis; midbrain development; midbrain-hindbrain boundary morphogenesis; negative regulation of amacrine cell differentiation; negative regulation of calcium ion import; negative regulation of cell differentiation; negative regulation of cell fate determination; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of forebrain neuron differentiation; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of inner ear auditory receptor cell differentiation; negative regulation of inner ear receptor cell differentiation; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of neuron projection development; negative regulation of oligodendrocyte differentiation; negative regulation of pancreatic A cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of stomach neuroendocrine cell differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; neural tube development; neuroendocrine cell differentiation; neuron differentiation; neuronal stem cell population maintenance; Notch signaling pathway; oculomotor nerve development; outflow tract morphogenesis; pancreas development; pancreatic A cell differentiation; pattern specification process; pharyngeal arch artery morphogenesis; pituitary gland development; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA binding; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of glial cell differentiation; positive regulation of mitotic cell cycle, embryonic; positive regulation of Notch signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; protein-containing complex assembly; regulation of DNA-templated transcription; regulation of epithelial cell proliferation; regulation of fat cell differentiation; regulation of neurogenesis; regulation of neuron differentiation; regulation of protein-containing complex assembly; regulation of receptor signaling pathway via JAK-STAT; regulation of secondary heart field cardioblast proliferation; regulation of timing of cell differentiation; regulation of timing of neuron differentiation; regulation of transcription by RNA polymerase II; renal interstitial fibroblast development; response to alkaloid; response to organic cyclic compound; response to thyroid hormone; smoothened signaling pathway; somatic stem cell population maintenance; S-shaped body morphogenesis; stomach neuroendocrine cell differentiation; T cell proliferation; telencephalon development; thymus development; trochlear nerve development; ureteric bud morphogenesis; vascular associated smooth muscle cell development; ventricular septum development; ventricular septum morphogenesis","chaperone binding; chromatin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; histone deacetylase binding; HLH domain binding; identical protein binding; JUN kinase binding; N-box binding; protein binding; protein dimerization activity; protein homodimerization activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription corepressor binding","chromatin; cytoplasm; nuclear matrix; nucleoplasm; nucleus; protein-containing complex",null,"hes family bHLH transcription factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=3280","3280","15205","29577",null,null,null,"Q14469","P35428","Q04666",null,null,null,"GO:0000785; GO:0005737; GO:0016363; GO:0005654; GO:0005634; GO:0032991","GO:0051087; GO:0003682; GO:0003677; GO:0000981; GO:0001217; GO:0001227; GO:0070888; GO:0042826; GO:0043398; GO:0042802; GO:0008432; GO:0071820; GO:0005515; GO:0046983; GO:0042803; GO:0044877; GO:0000978; GO:0061629; GO:0043565; GO:1990837; GO:0001222","GO:0021984; GO:0035881; GO:0009952; GO:0035909; GO:0048844; GO:0035910; GO:0030509; GO:0021870; GO:0061309; GO:0007155; GO:0045165; GO:0001709; GO:0048469; GO:0016477; GO:0048667; GO:0008283; GO:0071398; GO:0071347; GO:1990090; GO:0071356; GO:0090102; GO:0072049; GO:0061009; GO:0003143; GO:0035883; GO:0090162; GO:0021861; GO:0072012; GO:0035315; GO:0021575; GO:0001701; GO:0002085; GO:0042491; GO:0060122; GO:0060716; GO:0046331; GO:0001889; GO:0030324; GO:0072282; GO:0030901; GO:0021555; GO:1902870; GO:0090281; GO:0045596; GO:1905934; GO:0043433; GO:0045892; GO:2000978; GO:0010629; GO:0060253; GO:0045608; GO:2000981; GO:0050768; GO:0045665; GO:0010977; GO:0048715; GO:2000227; GO:2000974; GO:2000737; GO:0061106; GO:0000122; GO:0007399; GO:0021915; GO:0061101; GO:0030182; GO:0097150; GO:0007219; GO:0021557; GO:0003151; GO:0031016; GO:0003310; GO:0007389; GO:0061626; GO:0021983; GO:0048711; GO:0030513; GO:0008284; GO:0043388; GO:0045893; GO:0010628; GO:0045687; GO:0045977; GO:0045747; GO:0046427; GO:0042102; GO:0045944; GO:0042531; GO:0065003; GO:0006355; GO:0050678; GO:0045598; GO:0050767; GO:0045664; GO:0043254; GO:0046425; GO:0003266; GO:0048505; GO:0060164; GO:0006357; GO:0072141; GO:0043279; GO:0014070; GO:0097066; GO:0007224; GO:0035019; GO:0072050; GO:0061102; GO:0042098; GO:0021537; GO:0048538; GO:0021558; GO:0060675; GO:0097084; GO:0003281; GO:0060412","PTHR10985:SF77","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5192|UniProtKB=Q14469","P00045"]
["HES-4",null,"HES4","24","ms",null,2,1,1,8,8,8,"# 0927",".CSP., .DEV., .NOTCH., .OP., .OT., .TRASR.","Notch signaling pathway","TRANSCRIPTION FACTOR HES-4","anterior/posterior pattern specification; cell differentiation; nervous system development; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II","DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding","chromatin; nucleus","Transcription regulation","hes family bHLH transcription factor 4","http://www.ncbi.nlm.nih.gov/gene/?term=57801","57801",null,null,null,null,null,"Q9HCC6",null,null,"A0A8I3PC06",null,"A0A5F7ZSR7","GO:0000785; GO:0005634","GO:0003677; GO:0000981; GO:0005515; GO:0046983; GO:0000978","GO:0009952; GO:0030154; GO:0007399; GO:0006355; GO:0006357","PTHR10985:SF136","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24149|UniProtKB=Q9HCC6","P00045"]
["Hexokinase I",null,"HK1","102","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2835",".CAMET., .CANCER., .CSP., .HIF., .IIR., .IMFR., .IMU., .IMUR., .INS., .OP., .OPA., .OT., .SREME., .ST., .TRASR.","Glycolysis; Pentose phosphate pathway; Fructose galactose metabolism","HEXOKINASE-1","canonical glycolysis; carbohydrate metabolic process; carbohydrate phosphorylation; cellular glucose homeostasis; establishment of protein localization to mitochondrion; fructose 6-phosphate metabolic process; glucose 6-phosphate metabolic process; glucose metabolic process; glycolytic process; hexose metabolic process; immune system process; inflammatory response; innate immune response; maintenance of protein location in mitochondrion; mannose metabolic process; metabolic process; organophosphate metabolic process; phosphorylation; positive regulation of cytokine production involved in immune response; positive regulation of interleukin-1 beta production","ATP binding; catalytic activity; fructokinase activity; glucokinase activity; glucosamine kinase activity; glucose binding; hexokinase activity; kinase activity; mannokinase activity; nucleotide binding; peptidoglycan binding; phosphotransferase activity, alcohol group as acceptor; protein binding; transferase activity","cytoplasm; cytosol; membrane; membrane raft; mitochondrial outer membrane; mitochondrion",null,"hexokinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=3098","3098","15275",null,null,null,null,"P19367","P17710","A0A8I5YBQ4","A0A8I3MIF5","A0A287A1G6","F6Q724","GO:0005737; GO:0005829; GO:0016020; GO:0045121; GO:0005741; GO:0005739","GO:0005524; GO:0003824; GO:0008865; GO:0004340; GO:0047931; GO:0005536; GO:0004396; GO:0016301; GO:0019158; GO:0000166; GO:0042834; GO:0016773; GO:0005515; GO:0016740","GO:0061621; GO:0005975; GO:0046835; GO:0001678; GO:0072655; GO:0006002; GO:0051156; GO:0006006; GO:0006096; GO:0019318; GO:0002376; GO:0006954; GO:0045087; GO:0072656; GO:0006013; GO:0008152; GO:0019637; GO:0016310; GO:0002720; GO:0032731","PTHR19443:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4922|UniProtKB=P19367","P00024; P02762; P02744"]
["Hexokinase II",null,"HK2","102","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2834",".ANG., .APH., .APO., .CAMET., .CANCER., .CD., .CSP., .HIF., .INS., .OP., .OPA., .OXS., .SREME., .ST.","Glycolysis; Pentose phosphate pathway; Fructose galactose metabolism","HEXOKINASE-2","apoptotic mitochondrial changes; canonical glycolysis; carbohydrate metabolic process; carbohydrate phosphorylation; cellular glucose homeostasis; cellular response to leukemia inhibitory factor; establishment of protein localization to mitochondrion; fructose 6-phosphate metabolic process; glucose 6-phosphate metabolic process; glucose metabolic process; glycolytic process; hexose metabolic process; lactation; maintenance of protein location in mitochondrion; metabolic process; negative regulation of mitochondrial membrane permeability; negative regulation of reactive oxygen species metabolic process; organophosphate metabolic process; phosphorylation; positive regulation of angiogenesis; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization; regulation of glucose import; response to hypoxia; response to ischemia","ATP binding; catalytic activity; fructokinase activity; glucokinase activity; glucose binding; hexokinase activity; kinase activity; nucleotide binding; phosphotransferase activity, alcohol group as acceptor; protein binding; transferase activity","centrosome; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; mitochondrial outer membrane; mitochondrion; plasma membrane; sarcoplasmic reticulum",null,"hexokinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=3099","3099","15277","25059",null,null,null,"P52789","O08528","P27881","A0A8I3P147","A0A5G2R6R1","A0A5F7ZW66","GO:0005813; GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005741; GO:0005739; GO:0005886; GO:0016529","GO:0005524; GO:0003824; GO:0008865; GO:0004340; GO:0005536; GO:0004396; GO:0016301; GO:0000166; GO:0016773; GO:0005515; GO:0016740","GO:0008637; GO:0061621; GO:0005975; GO:0046835; GO:0001678; GO:1990830; GO:0072655; GO:0006002; GO:0051156; GO:0006006; GO:0006096; GO:0019318; GO:0007595; GO:0072656; GO:0008152; GO:0035795; GO:2000378; GO:0019637; GO:0016310; GO:0045766; GO:1904925; GO:0046324; GO:0001666; GO:0002931","PTHR19443:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4923|UniProtKB=P52789","P00024; P02762; P02744"]
["HGF",null,"HGF","83","gt",null,2,7,4,2,4,4,"TK # 049",".ANG., .APH., .APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .IMFR., .IMUR., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .P38., .PI3K., .RAS., .RCC., .RTK., .SREME., .ST., .TRASR.",null,"HEPATOCYTE GROWTH FACTOR","animal organ regeneration; cell chemotaxis; cell morphogenesis; cellular response to hepatocyte growth factor stimulus; epithelial cell proliferation; epithelial to mesenchymal transition; hepatocyte growth factor receptor signaling pathway; liver development; mitotic cell cycle; myoblast proliferation; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of inflammatory response; negative regulation of interleukin-6 production; negative regulation of peptidyl-serine phosphorylation; negative regulation of release of cytochrome c from mitochondria; positive chemotaxis; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of DNA biosynthetic process; positive regulation of interleukin-10 production; positive regulation of MAPK cascade; positive regulation of myelination; positive regulation of neuron projection regeneration; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; proteolysis; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; regulation of p38MAPK cascade; regulation of tau-protein kinase activity; skeletal muscle cell proliferation","chemoattractant activity; endopeptidase activity; growth factor activity; identical protein binding; protein binding; protein-containing complex binding; serine-type endopeptidase activity; signaling receptor binding","extracellular region; extracellular space; membrane; platelet alpha granule lumen","Tyrosine kinase / adaptor / protooncogene","hepatocyte growth factor","http://www.ncbi.nlm.nih.gov/gene/?term=3082","3082","15234",null,"403441",null,null,"P14210","Q08048","A0A8L2Q4D1","Q867B7","A0A287BRN0","F7A5F6","GO:0005576; GO:0005615; GO:0016020; GO:0031093","GO:0042056; GO:0004175; GO:0008083; GO:0042802; GO:0005515; GO:0044877; GO:0004252; GO:0005102","GO:0031100; GO:0060326; GO:0000902; GO:0035729; GO:0050673; GO:0001837; GO:0048012; GO:0001889; GO:0000278; GO:0051450; GO:0043066; GO:0010507; GO:0043154; GO:1902042; GO:1901299; GO:0050728; GO:0032715; GO:0033137; GO:0090201; GO:0050918; GO:0045766; GO:0030335; GO:2000573; GO:0032733; GO:0043410; GO:0031643; GO:0070572; GO:0045669; GO:0050731; GO:0014068; GO:0001934; GO:0045944; GO:0006508; GO:0060665; GO:1900744; GO:1902947; GO:0014856","PTHR24261:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4893|UniProtKB=P14210"]
["HIF1 alpha",null,"HIF1A","120","rb",null,1.1000000000000001,7,4,4,4,4,"# 0694",".ANG., .APH., .APO., .BCR., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .HIF., .IMUF., .IMUR., .INFM., .MIG., .MTOR., .OP., .OPA., .OT., .OXS., .RCC., .RTK., .SREME., .ST., .TCD., .TMAT., .TRASR., .VEGFS., .VIR.","VEGF signaling pathway; Angiogenesis; Hypoxia response via HIF activation","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA","angiogenesis; apoptotic process; axonal transport of mitochondrion; B-1 B cell homeostasis; blood vessel development; blood vessel morphogenesis; bone mineralization; camera-type eye morphogenesis; cardiac ventricle morphogenesis; cartilage development; cell differentiation; cellular glucose homeostasis; cellular iron ion homeostasis; cellular oxygen homeostasis; cellular response to hypoxia; cellular response to interleukin-1; cellular response to virus; cerebral cortex development; chondrocyte differentiation; collagen metabolic process; connective tissue replacement involved in inflammatory response wound healing; digestive tract morphogenesis; dopaminergic neuron differentiation; elastin metabolic process; embryonic hemopoiesis; embryonic placenta development; epithelial cell differentiation involved in mammary gland alveolus development; epithelial to mesenchymal transition; glandular epithelial cell differentiation; glandular epithelial cell maturation; glucose homeostasis; heart looping; hemoglobin biosynthetic process; hypoxia-inducible factor-1alpha signaling pathway; insulin secretion involved in cellular response to glucose stimulus; intestinal epithelial cell maturation; iris morphogenesis; lactate metabolic process; lactation; mesenchymal cell apoptotic process; muscle cell cellular homeostasis; negative regulation of apoptotic process; negative regulation of bone mineralization; negative regulation of gene expression; negative regulation of growth; negative regulation of mesenchymal cell apoptotic process; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; negative regulation of reactive oxygen species metabolic process; negative regulation of thymocyte apoptotic process; negative regulation of TOR signaling; neural crest cell migration; neural fold elevation formation; neuroblast proliferation; neuron apoptotic process; outflow tract morphogenesis; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of autophagy of mitochondrion; positive regulation of blood vessel endothelial cell migration; positive regulation of chemokine production; positive regulation of chemokine-mediated signaling pathway; positive regulation of cytokine production involved in inflammatory response; positive regulation of DNA-templated transcription; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of glycolytic process; positive regulation of hormone biosynthetic process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of macroautophagy; positive regulation of miRNA transcription; positive regulation of neuroblast proliferation; positive regulation of nitric-oxide synthase activity; positive regulation of signaling receptor activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of vascular endothelial growth factor production; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of aerobic respiration; regulation of catalytic activity; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of gene expression; regulation of glycolytic process; regulation of protein neddylation; regulation of thymocyte apoptotic process; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; regulation of transforming growth factor beta2 production; response to hypoxia; response to iron ion; response to muscle activity; response to reactive oxygen species; retina vasculature development in camera-type eye; signal transduction; TOR signaling; vascular endothelial growth factor production; vasculature development; visual learning","DNA binding; DNA-binding transcription activator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; enzyme binding; histone deacetylase binding; Hsp90 protein binding; nuclear receptor binding; p53 binding; protein binding; protein dimerization activity; protein domain specific binding; protein heterodimerization activity; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator binding; transcription regulator activator activity; ubiquitin protein ligase binding","axon cytoplasm; chromatin; cytoplasm; cytosol; euchromatin; motile cilium; nuclear body; nuclear speck; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription regulator complex","Translational control","hypoxia inducible factor 1 subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=3091","3091","15251","29560","480348",null,null,"Q16665","Q61221","D4A8P8","A0A8I3PI05","A0A287B1P3","F7HKJ2","GO:1904115; GO:0000785; GO:0005737; GO:0005829; GO:0000791; GO:0031514; GO:0016604; GO:0016607; GO:0005654; GO:0005634; GO:0032991; GO:0090575","GO:0003677; GO:0001216; GO:0001228; GO:0003700; GO:0000981; GO:0070888; GO:0019899; GO:0042826; GO:0051879; GO:0016922; GO:0002039; GO:0005515; GO:0046983; GO:0019904; GO:0046982; GO:0019901; GO:0000978; GO:0000977; GO:0061629; GO:0043565; GO:0001223; GO:0140537; GO:0031625","GO:0001525; GO:0006915; GO:0019896; GO:0001922; GO:0001568; GO:0048514; GO:0030282; GO:0048593; GO:0003208; GO:0051216; GO:0030154; GO:0001678; GO:0006879; GO:0032364; GO:0071456; GO:0071347; GO:0098586; GO:0021987; GO:0002062; GO:0032963; GO:0002248; GO:0048546; GO:0071542; GO:0051541; GO:0035162; GO:0001892; GO:0061030; GO:0001837; GO:0002067; GO:0002071; GO:0042593; GO:0001947; GO:0042541; GO:0097411; GO:0035773; GO:0060574; GO:0061072; GO:0006089; GO:0007595; GO:0097152; GO:0046716; GO:0043066; GO:0030502; GO:0010629; GO:0045926; GO:2001054; GO:0043524; GO:0030279; GO:1903377; GO:2000378; GO:0070244; GO:0032007; GO:0001755; GO:0021502; GO:0007405; GO:0051402; GO:0003151; GO:0045766; GO:0010508; GO:1903599; GO:0043536; GO:0032722; GO:0070101; GO:1900017; GO:0045893; GO:0001938; GO:0010634; GO:0045648; GO:0010628; GO:0045821; GO:0046886; GO:0035774; GO:0016239; GO:1902895; GO:0002052; GO:0051000; GO:2000273; GO:0045944; GO:0061419; GO:0010575; GO:0030949; GO:1903715; GO:0050790; GO:0042127; GO:0006355; GO:0010468; GO:0006110; GO:2000434; GO:0070243; GO:0006357; GO:0043619; GO:0032909; GO:0001666; GO:0010039; GO:0014850; GO:0000302; GO:0061298; GO:0007165; GO:0031929; GO:0010573; GO:0001944; GO:0008542","PTHR23043:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4910|UniProtKB=Q16665","P00056; P00005; P00030"]
["HIF1 beta (ARNT)",null,"ARNT","87","rb",null,2,1,1.1000000000000001,8,8,8,"# 1092",".CANCER., .CANPTHW., .CCP., .CP., .CSP., .HIF., .OP., .OPA., .OT., .OXS., .RCC., .RTK., .SREME., .ST., .TRASR., .VEGFS.","Hypoxia response via HIF activation","ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR","cell differentiation; embryonic placenta development; intracellular receptor signaling pathway; positive regulation of DNA-templated transcription; positive regulation of endothelial cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of glycolytic process; positive regulation of hormone biosynthetic process; positive regulation of protein sumoylation; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial growth factor production; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; response to hypoxia","aryl hydrocarbon receptor binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding","aryl hydrocarbon receptor complex; chromatin; cytoplasm; nuclear aryl hydrocarbon receptor complex; nuclear body; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex",null,"aryl hydrocarbon receptor nuclear translocator","http://www.ncbi.nlm.nih.gov/gene/?term=405","405","11863",null,"608843",null,null,"P27540","P53762","A0A0G2K804","Q3ZKN1","A0A5G2QRH6","A0A1D5R7N2","GO:0034751; GO:0000785; GO:0005737; GO:0034753; GO:0016604; GO:0005654; GO:0005634; GO:0090575; GO:0005667","GO:0017162; GO:0000987; GO:0003677; GO:0003700; GO:0000981; GO:0004879; GO:0005515; GO:0046983; GO:0046982; GO:0042803; GO:0000978; GO:0061629; GO:0043565; GO:1990837","GO:0030154; GO:0001892; GO:0030522; GO:0045893; GO:0001938; GO:0045648; GO:0045821; GO:0046886; GO:0033235; GO:0045944; GO:0010575; GO:0030949; GO:0006355; GO:0006357; GO:0043619; GO:0001666","PTHR23042:SF50","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=700|UniProtKB=P27540","P00030"]
["HINT2",null,"HINT2","17","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2987",".APO., .CD., .CSP.",null,"HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL","apoptotic process; lipid catabolic process; lipid metabolic process; negative regulation of peptidyl-lysine acetylation; steroid biosynthetic process","adenosine 5'-monophosphoramidase activity; catalytic activity; hydrolase activity; nucleotide binding","cytoplasm; mitochondrial outer membrane; mitochondrion",null,"histidine triad nucleotide binding protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=84681","84681","68917","313491",null,null,"695521","Q9BX68","Q9D0S9","D4AB01","A0A8I3NC75",null,"F7GRL0","GO:0005737; GO:0005741; GO:0005739","GO:0043530; GO:0003824; GO:0016787; GO:0000166","GO:0006915; GO:0016042; GO:0006629; GO:2000757; GO:0006694","PTHR23089:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18344|UniProtKB=Q9BX68"]
["Histone deacetylase 1 (HDAC1)",null,"HDAC1","62","rb",null,1,1,8,8,8,8,"# 1165",".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DEV., .DI., .HUNT., .IMUF., .IMUR., .MIG., .NFKB., .NOTCH., .OP., .OPA., .OT., .P53S., .ST., .TGFB., .TRASR., .VIR., .WNT.","p53 pathway; Wnt signaling pathway","HISTONE DEACETYLASE 1","cellular response to platelet-derived growth factor stimulus; chromatin organization; chromatin remodeling; circadian regulation of gene expression; circadian rhythm; DNA methylation-dependent heterochromatin formation; embryonic digit morphogenesis; endoderm development; epidermal cell differentiation; eyelid development in camera-type eye; fungiform papilla formation; hair follicle placode formation; hippocampus development; histone deacetylation; histone H3 deacetylation; histone H4 deacetylation; negative regulation by host of viral transcription; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cell migration; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of myotube differentiation; negative regulation of stem cell population maintenance; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuron differentiation; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of oligodendrocyte differentiation; positive regulation of signaling receptor activity; positive regulation of smooth muscle cell proliferation; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; protein deacetylation; regulation of amyloid-beta clearance; regulation of cell fate specification; regulation of endopeptidase activity; regulation of stem cell differentiation; regulation of transcription by RNA polymerase II; rhythmic process","chromatin binding; core promoter sequence-specific DNA binding; deacetylase activity; DNA binding; DNA-binding transcription factor binding; E-box binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; histone decrotonylase activity; hydrolase activity; Krueppel-associated box domain binding; NF-kappaB binding; nucleosomal DNA binding; p53 binding; promoter-specific chromatin binding; protein binding; protein decrotonylase activity; protein lysine deacetylase activity; protein N-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription cis-regulatory region binding; transcription corepressor activity; transcription corepressor binding","chromatin; cytoplasm; cytosol; heterochromatin; histone deacetylase complex; neuronal cell body; nucleoplasm; nucleus; NuRD complex; protein-containing complex; Sin3 complex; transcription regulator complex; transcription repressor complex","Chromatin regulation / epigenetics","histone deacetylase 1","http://www.ncbi.nlm.nih.gov/gene/?term=3065","3065","433759","297893","487309",null,null,"Q13547","O09106","Q4QQW4","A0A8I3MVP1","A0A5G2RAM8","F6WIM9","GO:0000785; GO:0005737; GO:0005829; GO:0000792; GO:0000118; GO:0043025; GO:0005654; GO:0005634; GO:0016581; GO:0032991; GO:0016580; GO:0005667; GO:0017053","GO:0003682; GO:0001046; GO:0019213; GO:0003677; GO:0140297; GO:0070888; GO:0019899; GO:0004407; GO:0042826; GO:0160009; GO:0016787; GO:0035851; GO:0051059; GO:0031492; GO:0002039; GO:1990841; GO:0005515; GO:0160008; GO:0033558; GO:0047485; GO:0000978; GO:0000979; GO:0061629; GO:0000976; GO:0003714; GO:0001222","GO:0036120; GO:0006325; GO:0006338; GO:0032922; GO:0007623; GO:0006346; GO:0042733; GO:0007492; GO:0009913; GO:0061029; GO:0061198; GO:0060789; GO:0021766; GO:0016575; GO:0070932; GO:0070933; GO:0043922; GO:0060766; GO:0043066; GO:0090090; GO:0030336; GO:0045892; GO:0010629; GO:0043124; GO:2001243; GO:0010832; GO:1902455; GO:0000122; GO:0030512; GO:0030182; GO:0042475; GO:0048709; GO:0008284; GO:0045893; GO:0010628; GO:0048714; GO:2000273; GO:0048661; GO:1902459; GO:0045944; GO:0006476; GO:1900221; GO:0042659; GO:0052548; GO:2000736; GO:0006357; GO:0048511","PTHR48252:SF36","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4852|UniProtKB=Q13547","P00059; P00057"]
["Histone deacetylase 2 (HDAC2)",null,"HDAC2","55","rb",null,1,1,8,8.1,8,8,"# 1680",".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DEV., .DI., .DRR., .HUNT., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .P53S., .RTK., .SREME., .ST., .STAT., .TGFB., .TRASR., .WNT.","p53 pathway; Wnt signaling pathway","HISTONE DEACETYLASE 2","behavioral response to ethanol; cardiac muscle hypertrophy; cellular response to dopamine; cellular response to heat; cellular response to hydrogen peroxide; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; chromatin organization; chromatin remodeling; circadian regulation of gene expression; dendrite development; embryonic digit morphogenesis; epidermal cell differentiation; eyelid development in camera-type eye; fungiform papilla formation; hair follicle placode formation; heterochromatin organization; histone deacetylation; histone H3 deacetylation; histone H4 deacetylation; negative regulation of apoptotic process; negative regulation of cell migration; negative regulation of dendritic spine development; negative regulation of DNA binding; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of MHC class II biosynthetic process; negative regulation of neuron projection development; negative regulation of peptidyl-lysine acetylation; negative regulation of stem cell population maintenance; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; odontogenesis of dentin-containing tooth; positive regulation of cell population proliferation; positive regulation of collagen biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of interleukin-1 production; positive regulation of male mating behavior; positive regulation of oligodendrocyte differentiation; positive regulation of proteolysis; positive regulation of signaling receptor activity; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of STAT protein; regulation of cell fate specification; regulation of stem cell differentiation; regulation of transcription by RNA polymerase II; response to amphetamine; response to caffeine; response to cocaine; response to hyperoxia; response to lipopolysaccharide; response to nicotine; response to xenobiotic stimulus; rhythmic process","chromatin binding; deacetylase activity; enzyme binding; heat shock protein binding; histone deacetylase activity; histone deacetylase binding; histone decrotonylase activity; hydrolase activity; NF-kappaB binding; nucleosomal DNA binding; promoter-specific chromatin binding; protein binding; protein de-2-hydroxyisobutyrylase activity; protein decrotonylase activity; protein lysine deacetylase activity; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding","chromatin; chromosome, telomeric region; cytoplasm; ESC/E(Z) complex; histone deacetylase complex; nucleoplasm; nucleus; NuRD complex; protein-containing complex; Sin3 complex","Chromatin regulation / epigenetics","histone deacetylase 2","http://www.ncbi.nlm.nih.gov/gene/?term=3066","3066","15182",null,null,null,null,"Q92769","A0A0R4J008","A0A8I6AP99","A0A8I3S1X7","A0A5G2QGU2","F7EW26","GO:0000785; GO:0000781; GO:0005737; GO:0035098; GO:0000118; GO:0005654; GO:0005634; GO:0016581; GO:0032991; GO:0016580","GO:0003682; GO:0019213; GO:0019899; GO:0031072; GO:0004407; GO:0042826; GO:0160009; GO:0016787; GO:0051059; GO:0031492; GO:1990841; GO:0005515; GO:0160010; GO:0160008; GO:0033558; GO:0003723; GO:0061629; GO:0043565","GO:0048149; GO:0003300; GO:1903351; GO:0034605; GO:0070301; GO:0071300; GO:0071560; GO:0006325; GO:0006338; GO:0032922; GO:0016358; GO:0042733; GO:0009913; GO:0061029; GO:0061198; GO:0060789; GO:0070828; GO:0016575; GO:0070932; GO:0070933; GO:0043066; GO:0030336; GO:0061000; GO:0043392; GO:0043433; GO:0045892; GO:0045347; GO:0010977; GO:2000757; GO:1902455; GO:0000122; GO:0030512; GO:0042475; GO:0008284; GO:0032967; GO:0045893; GO:0010718; GO:0032732; GO:1902437; GO:0048714; GO:0045862; GO:2000273; GO:1902459; GO:0045944; GO:0032760; GO:0042531; GO:0042659; GO:2000736; GO:0006357; GO:0001975; GO:0031000; GO:0042220; GO:0055093; GO:0032496; GO:0035094; GO:0009410; GO:0048511","PTHR48252:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4853|UniProtKB=Q92769","P00059; P00057"]
["Histone deacetylase 3 (HDAC3)",null,"HDAC3","49","rb",null,2,1.1000000000000001,4,4,8,8,"# 0734",".APO., .CCP., .CCY., .CD., .CSP., .DEV., .JNK., .MTOR., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TRASR., .UBI., .WNT.","Wnt signaling pathway","HISTONE DEACETYLASE 3","cellular response to fluid shear stress; chromatin organization; circadian regulation of gene expression; cornified envelope assembly; epidermis development; establishment of skin barrier; gene expression; histone deacetylation; histone H4 deacetylation; histone H4-K12 deacetylation; in utero embryonic development; negative regulation of apoptotic process; negative regulation of cardiac muscle cell differentiation; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of JNK cascade; negative regulation of myotube differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of cold-induced thermogenesis; positive regulation of protein import into nucleus; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of TOR signaling; positive regulation of transcription by RNA polymerase II; protein deacetylation; regulation of circadian rhythm; regulation of mitotic cell cycle; regulation of multicellular organism growth; regulation of protein stability; regulation of transcription by RNA polymerase II; rhythmic process; spindle assembly; transcription by RNA polymerase II","chromatin binding; chromatin DNA binding; cyclin binding; DNA binding; DNA-binding transcription factor binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; histone decrotonylase activity; hydrolase activity; NF-kappaB binding; protein binding; protein de-2-hydroxyisobutyrylase activity; protein decrotonylase activity; protein lysine deacetylase activity; transcription corepressor activity; transcription corepressor binding","cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; mitotic spindle; nucleoplasm; nucleus; plasma membrane; transcription repressor complex","Chromatin regulation / epigenetics","histone deacetylase 3","http://www.ncbi.nlm.nih.gov/gene/?term=8841","8841","15183",null,"478040",null,null,"O15379","O88895","A0A0G2K1C8","A0A8I3P468","A0A287B575","A0A5F8ABE8","GO:0005737; GO:0005829; GO:0005794; GO:0000118; GO:0072686; GO:0005654; GO:0005634; GO:0005886; GO:0017053","GO:0003682; GO:0031490; GO:0030332; GO:0003677; GO:0140297; GO:0019899; GO:0004407; GO:0042826; GO:0160009; GO:0016787; GO:0051059; GO:0005515; GO:0160010; GO:0160008; GO:0033558; GO:0003714; GO:0001222","GO:0071498; GO:0006325; GO:0032922; GO:1903575; GO:0008544; GO:0061436; GO:0010467; GO:0016575; GO:0070933; GO:1990679; GO:0001701; GO:0043066; GO:2000726; GO:0043433; GO:0045892; GO:0046329; GO:0010832; GO:0000122; GO:0120162; GO:0042307; GO:0001934; GO:0031398; GO:0032008; GO:0045944; GO:0006476; GO:0042752; GO:0007346; GO:0040014; GO:0031647; GO:0006357; GO:0048511; GO:0051225; GO:0006366","PTHR48252:SF69","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4854|UniProtKB=O15379","P00057"]
["Histone deacetylase 6 (HDAC6)",null,"HDAC6","134","rb",null,2,2,8,2,2,2,"# 0739",".APH., .CCP., .CD., .CP., .CSP., .MIG., .OP., .OPA., .OT., .OXS., .SREME., .ST., .TRASR., .UBI.",null,"HISTONE DEACETYLASE 6","aggresome assembly; autophagy; axonal transport of mitochondrion; cellular response to hydrogen peroxide; cellular response to misfolded protein; cellular response to oxidative stress; cellular response to parathyroid hormone stimulus; cellular response to topologically incorrect protein; chromatin organization; cilium assembly; cilium disassembly; collateral sprouting; dendritic spine morphogenesis; epigenetic regulation of gene expression; histone deacetylation; Hsp90 deacetylation; intracellular protein transport; lysosome localization; mitochondrion localization; negative regulation of axon extension involved in axon guidance; negative regulation of DNA-templated transcription; negative regulation of hydrogen peroxide metabolic process; negative regulation of microtubule depolymerization; negative regulation of neuron projection development; negative regulation of oxidoreductase activity; negative regulation of protein acetylation; negative regulation of protein-containing complex assembly; negative regulation of protein-containing complex disassembly; negative regulation of proteolysis; negative regulation of transcription by RNA polymerase II; neuron differentiation; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; peptidyl-lysine deacetylation; polyamine deacetylation; polyubiquitinated misfolded protein transport; positive regulation of cholangiocyte proliferation; positive regulation of dendrite morphogenesis; positive regulation of epithelial cell migration; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of mitophagy in response to mitochondrial depolarization; positive regulation of oxidative stress-induced neuron death; positive regulation of peptidyl-serine phosphorylation; positive regulation of signaling receptor activity; positive regulation of synaptic transmission, glutamatergic; positive regulation of tubulin deacetylation; protein deacetylation; protein destabilization; protein polyubiquitination; protein quality control for misfolded or incompletely synthesized proteins; protein-containing complex disassembly; regulation of androgen receptor signaling pathway; regulation of autophagy; regulation of autophagy of mitochondrion; regulation of establishment of protein localization; regulation of fat cell differentiation; regulation of macroautophagy; regulation of microtubule cytoskeleton organization; regulation of microtubule-based movement; regulation of mitochondrion organization; regulation of protein phosphorylation; regulation of protein stability; response to amphetamine; response to corticosterone; response to dexamethasone; response to growth factor; response to immobilization stress; response to misfolded protein; spermidine deacetylation; tubulin deacetylation; ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway","acetylspermidine deacetylase activity; actin binding; alpha-tubulin binding; beta-catenin binding; beta-tubulin binding; deacetylase activity; dynein complex binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; Hsp90 protein binding; hydrolase activity; metal ion binding; microtubule binding; misfolded protein binding; polyubiquitin modification-dependent protein binding; protein binding; protein lysine deacetylase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; tau protein binding; transcription corepressor binding; tubulin deacetylase activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding","aggresome; axon; axon cytoplasm; caveola; cell leading edge; cell projection; centrosome; ciliary basal body; cilium; cytoplasm; cytoskeleton; cytosol; dendrite; histone deacetylase complex; inclusion body; microtubule; microtubule associated complex; microtubule cytoskeleton; multivesicular body; neuron projection; neuronal cell body; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; protein-containing complex","Chromatin regulation / epigenetics","histone deacetylase 6","http://www.ncbi.nlm.nih.gov/gene/?term=10013","10013","15185","108348065",null,null,null,"Q9UBN7","Q9Z2V5","A0A0G2QC41","A0A8I3Q5U6","A0A286ZT11","A0A5F7Z9U3","GO:0016235; GO:0030424; GO:1904115; GO:0005901; GO:0031252; GO:0042995; GO:0005813; GO:0036064; GO:0005929; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0000118; GO:0016234; GO:0005874; GO:0005875; GO:0015630; GO:0005771; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0043204; GO:0048471; GO:0032991","GO:0047611; GO:0003779; GO:0043014; GO:0008013; GO:0048487; GO:0019213; GO:0070840; GO:0019899; GO:0004407; GO:0042826; GO:0051879; GO:0016787; GO:0046872; GO:0008017; GO:0051787; GO:0031593; GO:0005515; GO:0033558; GO:0000978; GO:0048156; GO:0001222; GO:0042903; GO:0043130; GO:0031625; GO:0008270","GO:0070842; GO:0006914; GO:0019896; GO:0070301; GO:0071218; GO:0034599; GO:0071374; GO:0035967; GO:0006325; GO:0060271; GO:0061523; GO:0048668; GO:0060997; GO:0040029; GO:0016575; GO:0070846; GO:0006886; GO:0032418; GO:0051646; GO:0048843; GO:0045892; GO:0010727; GO:0007026; GO:0010977; GO:0051354; GO:1901984; GO:0031333; GO:0043242; GO:0045861; GO:0000122; GO:0030182; GO:0061734; GO:0034983; GO:0106047; GO:0070845; GO:1904056; GO:0050775; GO:0010634; GO:1901300; GO:0098779; GO:1903223; GO:0033138; GO:2000273; GO:0051968; GO:0090044; GO:0006476; GO:0031648; GO:0000209; GO:0006515; GO:0032984; GO:0060765; GO:0010506; GO:1903146; GO:0070201; GO:0045598; GO:0016241; GO:0070507; GO:0060632; GO:0010821; GO:0001932; GO:0031647; GO:0001975; GO:0051412; GO:0071548; GO:0070848; GO:0035902; GO:0051788; GO:0106048; GO:0090042; GO:0006511; GO:0043162","PTHR48252:SF71","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=14064|UniProtKB=Q9UBN7"]
["Histone H2A.X - phospho","Ser139","H2AX","15","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1611",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .OP.",null,"HISTONE H2AX","cell cycle; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular senescence; cerebral cortex development; DNA damage checkpoint signaling; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; meiotic cell cycle; nucleosome assembly; positive regulation of DNA repair; response to ionizing radiation; spermatogenesis","damaged DNA binding; DNA binding; enzyme binding; histone binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","centrosome; chromatin; chromosome; chromosome, telomeric region; condensed nuclear chromosome; extracellular exosome; intracellular organelle; male germ cell nucleus; nuclear speck; nucleoplasm; nucleosome; nucleus; replication fork; site of DNA damage; site of double-strand break; XY body","Chromatin regulation / epigenetics","H2A.X variant histone","http://www.ncbi.nlm.nih.gov/gene/?term=3014","3014","15270","500987","489372",null,"703073","P16104","P27661","D3ZXP3","A0A8I3RP66",null,"A0A1D5Q5B3","GO:0005813; GO:0000785; GO:0005694; GO:0000781; GO:0000794; GO:0070062; GO:0043229; GO:0001673; GO:0016607; GO:0005654; GO:0000786; GO:0005634; GO:0005657; GO:0090734; GO:0035861; GO:0001741","GO:0003684; GO:0003677; GO:0019899; GO:0042393; GO:0005515; GO:0046982; GO:0030527","GO:0007049; GO:0006974; GO:0071480; GO:0090398; GO:0021987; GO:0000077; GO:0006310; GO:0006281; GO:0006302; GO:0000724; GO:0051321; GO:0006334; GO:0045739; GO:0010212; GO:0007283","PTHR23430:SF199","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4739|UniProtKB=P16104"]
["Histone H2B",null,"H2BC3","14","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2121",null,null,"HISTONE H2B TYPE 1-B","nucleosome assembly","DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromosome; chromosome, telomeric region; cytosol; intracellular organelle; nucleoplasm; nucleosome; nucleus",null,"H2B clustered histone 3","http://www.ncbi.nlm.nih.gov/gene/?term=3018","3018","319178",null,null,null,null,"P33778","Q64475",null,null,null,null,"GO:0005694; GO:0000781; GO:0005829; GO:0043229; GO:0005654; GO:0000786; GO:0005634","GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0006334","PTHR23428:SF353","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4751|UniProtKB=P33778"]
["Histone H2B - acetyl","Lys15","H2BC18","17","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0222",null,null,"HISTONE H2B TYPE 2-F","nucleosome assembly","DNA binding; molecular_function; protein heterodimerization activity; structural constituent of chromatin","chromosome; cytosol; extracellular exosome; intracellular organelle; nucleoplasm; nucleosome; nucleus","Chromatin regulation / epigenetics","H2B clustered histone 18","http://www.ncbi.nlm.nih.gov/gene/?term=440689","440689","319189",null,null,null,null,"Q5QNW6","Q64525",null,null,null,"F7BDR4","GO:0005694; GO:0005829; GO:0070062; GO:0043229; GO:0005654; GO:0000786; GO:0005634","GO:0003677; GO:0003674; GO:0046982; GO:0030527","GO:0006334","PTHR23428:SF364","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24700|UniProtKB=Q5QNW6"]
["Histone H2B - acetyl","Lys20","H2BC18","14","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0244",null,null,"HISTONE H2B TYPE 2-F","nucleosome assembly","DNA binding; molecular_function; protein heterodimerization activity; structural constituent of chromatin","chromosome; cytosol; extracellular exosome; intracellular organelle; nucleoplasm; nucleosome; nucleus","Chromatin regulation / epigenetics","H2B clustered histone 18","http://www.ncbi.nlm.nih.gov/gene/?term=440689","440689","319189",null,null,null,null,"Q5QNW6","Q64525",null,null,null,"F7BDR4","GO:0005694; GO:0005829; GO:0070062; GO:0043229; GO:0005654; GO:0000786; GO:0005634","GO:0003677; GO:0003674; GO:0046982; GO:0030527","GO:0006334","PTHR23428:SF364","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24700|UniProtKB=Q5QNW6"]
["Histone H2B type 2-F- acetyl","Lys5","H2BC18","16-14","rb",null,2,2,6,3,6,6,"# 1025",null,null,"HISTONE H2B TYPE 2-F","nucleosome assembly","DNA binding; molecular_function; protein heterodimerization activity; structural constituent of chromatin","chromosome; cytosol; extracellular exosome; intracellular organelle; nucleoplasm; nucleosome; nucleus","Chromatin regulation / epigenetics","H2B clustered histone 18","http://www.ncbi.nlm.nih.gov/gene/?term=440689","440689","319189",null,null,null,null,"Q5QNW6","Q64525",null,null,null,"F7BDR4","GO:0005694; GO:0005829; GO:0070062; GO:0043229; GO:0005654; GO:0000786; GO:0005634","GO:0003677; GO:0003674; GO:0046982; GO:0030527","GO:0006334","PTHR23428:SF364","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24700|UniProtKB=Q5QNW6"]
["Histone H3",null,"H3C1","17","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2241",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3",null,"H3C1","17","rb",null,1,1,1,8,2,2,"# 2470",".CCP., .CCY., .CUR., .D200., .D300., .DRAS., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - acetyl","Lys14","H3C1","17","rb",null,1,1,1.1000000000000001,8,8,8,"# 1156",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - acetyl","Lys18","H3C1","17","rb",null,1,1,1,8,8,8,"# 0945",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - acetyl","Lys23","H3C1","17","rb",null,1,2,1,8,8,8,"# 1123",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - acetyl","Lys9","H3C1","17","rb",null,1,1,1,8,8,8,"# 1089",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - acetyl","Lys9/Lys14","H3C1","17","rb",null,1,1,"n/a","n/a",8,8,"# 1614",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - acetyl/phospho","Lys9/Ser10","H3C1","17","rb",null,2,2.1,4,4,4,4,"# 1042",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - monomethyl","Lys4","H3C1","17","rb",null,1,1,1,8,8,8,"# 1039",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - phospho","Ser10","H3C1","17","rb",null,1,4,4,4,4,4,"# 2849",".CCP., .CCY., .CUR., .D200., .D300., .DRAS., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - phospho","Ser28","H3C1","17","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1058",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - phospho","Thr11","H3C1","15","rb",null,1.1000000000000001,4,"n/a","n/a","n/a","n/a","# 0941",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - phospho","Thr3","H3-4","17","rb",null,2,1,8,8,8,8,"# 1030",".CCP., .CCY., .OP.","DNA replication","HISTONE H3.1T","nucleosome assembly","DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; chromosome, telomeric region; extracellular exosome; nucleoplasm; nucleosome; nucleus","Chromatin regulation / epigenetics","H3.4 histone, cluster member","http://www.ncbi.nlm.nih.gov/gene/?term=8290","8290",null,null,null,null,null,"Q16695",null,null,null,null,null,"GO:0000785; GO:0005694; GO:0000781; GO:0070062; GO:0005654; GO:0000786; GO:0005634","GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0006334","PTHR11426:SF257","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4778|UniProtKB=Q16695","P00017"]
["Histone H3 - phospho","Thr6","H3C1","15","rb",null,2,7,7,7,7,7,"# 1060",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - trimethyl","Lys27","H3C1","17","rb",null,1,2,2,7,7,7,"# 0940",".CCP., .CCY., .OP., .OT., .TRASR.","DNA replication","HISTONE H3.1","epigenetic regulation of gene expression; nucleosome assembly; telomere organization","cadherin binding; DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=8350","8350","319152",null,null,null,null,"P68431","P68433",null,null,null,null,"GO:0000785; GO:0005694; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0045296; GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0040029; GO:0006334; GO:0032200","PTHR11426:SF242","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4766|UniProtKB=P68431","P00017"]
["Histone H3 - trimethyl","Lys4","H3-4","17","ms",null,4,7,"n/a","n/a","n/a","n/a","# 1040",".CCP., .CCY., .OP.","DNA replication","HISTONE H3.1T","nucleosome assembly","DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; chromosome, telomeric region; extracellular exosome; nucleoplasm; nucleosome; nucleus","Chromatin regulation / epigenetics","H3.4 histone, cluster member","http://www.ncbi.nlm.nih.gov/gene/?term=8290","8290",null,null,null,null,null,"Q16695",null,null,null,null,null,"GO:0000785; GO:0005694; GO:0000781; GO:0070062; GO:0005654; GO:0000786; GO:0005634","GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0006334","PTHR11426:SF257","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4778|UniProtKB=Q16695","P00017"]
["Histone H3 - trimethyl","Lys9","H3-4","17","rb",null,2,2,2,7,7,7,"# 0921",".CCP., .CCY., .OP.","DNA replication","HISTONE H3.1T","nucleosome assembly","DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin","chromatin; chromosome; chromosome, telomeric region; extracellular exosome; nucleoplasm; nucleosome; nucleus","Chromatin regulation / epigenetics","H3.4 histone, cluster member","http://www.ncbi.nlm.nih.gov/gene/?term=8290","8290",null,null,null,null,null,"Q16695",null,null,null,null,null,"GO:0000785; GO:0005694; GO:0000781; GO:0070062; GO:0005654; GO:0000786; GO:0005634","GO:0003677; GO:0005515; GO:0046982; GO:0030527","GO:0006334","PTHR11426:SF257","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4778|UniProtKB=Q16695","P00017"]
["Histone H3 / H3.3 - phospho","Ser28","H3-3A","17","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0204",".CCP., .CCY., .CP., .OP.","DNA replication","HISTONE H3.3-RELATED","nucleosome assembly; positive regulation of cell growth; telomere organization","DNA binding; nucleosomal DNA binding; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; structural constituent of chromatin","chromatin; chromosome; chromosome, telomeric region; extracellular exosome; extracellular region; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H3.3 histone A","http://www.ncbi.nlm.nih.gov/gene/?term=3020","3020","15078","100361558","475916","100521680",null,"P84243","P84244","P84245","E2R6K5","Q71LE2",null,"GO:0000785; GO:0005694; GO:0000781; GO:0070062; GO:0005576; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0003677; GO:0031492; GO:0005515; GO:0046982; GO:0000978; GO:0000979; GO:0030527","GO:0006334; GO:0030307; GO:0032200","PTHR11426:SF228","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4764|UniProtKB=P84243","P00017"]
["Histone H4",null,"H4C1","11","rb",null,2,2,2,7,7,7,"# 0264",null,null,"HISTONE H4","negative regulation of megakaryocyte differentiation; nucleosome assembly; protein localization to CENP-A containing chromatin; telomere organization","DNA binding; protein binding; protein domain specific binding; protein heterodimerization activity; RNA binding; structural constituent of chromatin","CENP-A containing nucleosome; chromosome; chromosome, telomeric region; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H4 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=121504","121504","100041230","291152",null,null,"106996511","P62805","P62806","P62804",null,null,"F7HAP8","GO:0043505; GO:0005694; GO:0000781; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0003677; GO:0005515; GO:0019904; GO:0046982; GO:0003723; GO:0030527","GO:0045653; GO:0006334; GO:0061644; GO:0032200","PTHR10484:SF194","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20510|UniProtKB=P62805"]
["Histone H4 - acetyl","Lys16","H4C1","11","rb",null,7,7,"n/a","n/a","n/a","n/a","BG/MP # 128",null,null,"HISTONE H4","negative regulation of megakaryocyte differentiation; nucleosome assembly; protein localization to CENP-A containing chromatin; telomere organization","DNA binding; protein binding; protein domain specific binding; protein heterodimerization activity; RNA binding; structural constituent of chromatin","CENP-A containing nucleosome; chromosome; chromosome, telomeric region; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H4 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=121504","121504","100041230","291152",null,null,"106996511","P62805","P62806","P62804",null,null,"F7HAP8","GO:0043505; GO:0005694; GO:0000781; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0003677; GO:0005515; GO:0019904; GO:0046982; GO:0003723; GO:0030527","GO:0045653; GO:0006334; GO:0061644; GO:0032200","PTHR10484:SF194","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20510|UniProtKB=P62805"]
["Histone H4 - acetyl","Lys8","H4C1","11","rb",null,2,4,"n/a","n/a","n/a","n/a","# 0938",null,null,"HISTONE H4","negative regulation of megakaryocyte differentiation; nucleosome assembly; protein localization to CENP-A containing chromatin; telomere organization","DNA binding; protein binding; protein domain specific binding; protein heterodimerization activity; RNA binding; structural constituent of chromatin","CENP-A containing nucleosome; chromosome; chromosome, telomeric region; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H4 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=121504","121504","100041230","291152",null,null,"106996511","P62805","P62806","P62804",null,null,"F7HAP8","GO:0043505; GO:0005694; GO:0000781; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0003677; GO:0005515; GO:0019904; GO:0046982; GO:0003723; GO:0030527","GO:0045653; GO:0006334; GO:0061644; GO:0032200","PTHR10484:SF194","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20510|UniProtKB=P62805"]
["Histone H4 - monomethyl","Lys20","H4C1","8","ms",null,1,4,1,8,8,8,"# 1073",null,null,"HISTONE H4","negative regulation of megakaryocyte differentiation; nucleosome assembly; protein localization to CENP-A containing chromatin; telomere organization","DNA binding; protein binding; protein domain specific binding; protein heterodimerization activity; RNA binding; structural constituent of chromatin","CENP-A containing nucleosome; chromosome; chromosome, telomeric region; extracellular exosome; extracellular region; membrane; nucleoplasm; nucleosome; nucleus; protein-containing complex","Chromatin regulation / epigenetics","H4 clustered histone 1","http://www.ncbi.nlm.nih.gov/gene/?term=121504","121504","100041230","291152",null,null,"106996511","P62805","P62806","P62804",null,null,"F7HAP8","GO:0043505; GO:0005694; GO:0000781; GO:0070062; GO:0005576; GO:0016020; GO:0005654; GO:0000786; GO:0005634; GO:0032991","GO:0003677; GO:0005515; GO:0019904; GO:0046982; GO:0003723; GO:0030527","GO:0045653; GO:0006334; GO:0061644; GO:0032200","PTHR10484:SF194","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20510|UniProtKB=P62805"]
["HKDC1",null,"HKDC1","102","rb",null,2,7,2,2,2.1,2.1,"TK # 113",".CAMET., .CANCER., .CSP., .HIF., .INS., .OP., .OPA., .SREME., .ST.","Glycolysis; Pentose phosphate pathway; Fructose galactose metabolism","HEXOKINASE HKDC1","carbohydrate metabolic process; carbohydrate phosphorylation; cellular glucose homeostasis; glucose 6-phosphate metabolic process; glucose metabolic process; glycolytic process; hexose metabolic process; organophosphate metabolic process; phosphorylation","ATP binding; fructokinase activity; glucokinase activity; glucose binding; hexokinase activity; kinase activity; nucleotide binding; phosphotransferase activity, alcohol group as acceptor; transferase activity","cytoplasm; cytosol; membrane; mitochondrial membrane; mitochondrion; photoreceptor inner segment",null,"hexokinase domain containing 1","http://www.ncbi.nlm.nih.gov/gene/?term=80201","80201","216019",null,"489019","100153520","711995","Q2TB90","Q91W97","M0R3X7","A0A8P0NNB7","A0A286ZQ27","F7HAC6","GO:0005737; GO:0005829; GO:0016020; GO:0031966; GO:0005739; GO:0001917","GO:0005524; GO:0008865; GO:0004340; GO:0005536; GO:0004396; GO:0016301; GO:0000166; GO:0016773; GO:0016740","GO:0005975; GO:0046835; GO:0001678; GO:0051156; GO:0006006; GO:0006096; GO:0019318; GO:0019637; GO:0016310","PTHR19443:SF28","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=23302|UniProtKB=Q2TB90","P00024; P02762; P02744"]
["HLA-A/B/C",null,"HLA-A, HLA-B, HLA-C","41","ms",null,6,4,"n/a","n/a","n/a","n/a","# 0544",".CSP., .IIR., .IMU., .IMUF., .IMUR., .OP., .OT., .TCR., .TRASR.",null,"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A ALPHA CHAIN; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B ALPHA CHAIN; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN","adaptive immune response; antibacterial humoral response; antigen processing and presentation; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; CD8-positive, alpha-beta T cell activation; defense response to Gram-positive bacterium; detection of bacterium; immune response; immune system process; innate immune response; positive regulation of CD8-positive, alpha-beta T cell activation; positive regulation of CD8-positive, alpha-beta T cell proliferation; positive regulation of memory T cell activation; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; positive regulation of type II interferon production; protection from natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity; T cell mediated cytotoxicity directed against tumor cell target; T cell receptor signaling pathway; defense response; regulation of dendritic cell differentiation; regulation of interleukin-12 production; regulation of interleukin-6 production; regulation of T cell anergy","beta-2-microglobulin binding; CD8 receptor binding; peptide antigen binding; protein binding; RNA binding; signaling receptor binding; T cell receptor binding; TAP binding; TAP complex binding; chaperone binding","cell surface; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; extracellular exosome; Golgi apparatus; Golgi medial cisterna; Golgi membrane; lumenal side of endoplasmic reticulum membrane; membrane; MHC class I peptide loading complex; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane; recycling endosome membrane; secretory granule membrane","MHC I receptor activity","major histocompatibility complex, class I, A; major histocompatibility complex, class I, B; major histocompatibility complex, class I, C","http://www.ncbi.nlm.nih.gov/gene/?term=3105, http://www.ncbi.nlm.nih.gov/gene/?term=3106, http://www.ncbi.nlm.nih.gov/gene/?term=3107","3105, 3106, 3107","","414784","",null,null,"P04439, P01889, P10321",null,"Q4G002, Q4G002, Q4G002",null,"A0A287AAB2, A0A287AAB2, A0A287AAB2","H9H5G5, H9H5G5","GO:0009986; GO:0031901; GO:0005783; GO:0070971; GO:0005789; GO:0012507; GO:0070062; GO:0005794; GO:0005797; GO:0000139; GO:0098553; GO:0016020; GO:0042824; GO:0042612; GO:0030670; GO:0005886; GO:0055038; GO:0030667","GO:0030881; GO:0042610; GO:0042605; GO:0005515; GO:0003723; GO:0005102; GO:0042608; GO:0046977; GO:0062061; GO:0051087","GO:0002250; GO:0019731; GO:0019882; GO:0019885; GO:0002485; GO:0002486; GO:0042590; GO:0002474; GO:0036037; GO:0050830; GO:0016045; GO:0006955; GO:0002376; GO:0045087; GO:2001187; GO:2000566; GO:2000568; GO:0002726; GO:0001916; GO:0032729; GO:0042270; GO:0001913; GO:0002419; GO:0050852; GO:0006952; GO:2001198; GO:0032655; GO:0032675; GO:0002667","PTHR16675:SF229; PTHR16675:SF270; PTHR16675:SF252","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4931|UniProtKB=P04439; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4932|UniProtKB=P01889; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4933|UniProtKB=P10321"]
["HLA-DMB",null,"HLA-DMB","29","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0988",".CSP., .IMU., .IMUF., .IMUR., .OP., .TCD., .TCR., .TMAT.","T cell activation","HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN","adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; immune response; immune system process; MHC class II protein complex assembly; peptide antigen assembly with MHC class II protein complex; positive regulation of T cell activation; positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of T cell proliferation","MHC class II protein complex binding; protein binding","endosome; intracellular membrane-bounded organelle; late endosome membrane; lysosomal membrane; lysosome; membrane; MHC class II protein complex","MHC II receptor activity","major histocompatibility complex, class II, DM beta","http://www.ncbi.nlm.nih.gov/gene/?term=3109","3109","14999",null,null,null,null,"P28068","Q31094","A0A8I6ANG9",null,"A0A8W4FFL0","A0A5F7Z8I3","GO:0005768; GO:0043231; GO:0031902; GO:0005765; GO:0005764; GO:0016020; GO:0042613","GO:0023026; GO:0005515","GO:0002250; GO:0019882; GO:0019886; GO:0002504; GO:0006955; GO:0002376; GO:0002399; GO:0002503; GO:0050870; GO:2001190; GO:0042102","PTHR19944:SF65","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4935|UniProtKB=P28068","P00053"]
["HLA-DR alpha chain",null,"HLA-DRA","35","rb",null,2,1,1,1,8,2.1,"# 0449",".CSP., .IMU., .IMUF., .IMUR., .OP., .TCD., .TCR., .TMAT.","T cell activation","HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN-RELATED","adaptive immune response; antigen processing and presentation; antigen processing and presentation of endogenous peptide antigen via MHC class II; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; cognition; immune response; immune system process; myeloid dendritic cell antigen processing and presentation; peptide antigen assembly with MHC class II protein complex; positive regulation of CD4-positive, alpha-beta T cell activation; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of memory T cell differentiation; positive regulation of T cell activation; positive regulation of T cell mediated cytotoxicity; regulation of T-helper cell differentiation","MHC class II protein complex binding; MHC class II receptor activity; peptide antigen binding; polysaccharide binding; protein binding; T cell receptor binding","cell surface; clathrin-coated endocytic vesicle membrane; cytoplasmic vesicle; early endosome membrane; endocytic vesicle membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; ER to Golgi transport vesicle membrane; extracellular exosome; Golgi membrane; immunological synapse; late endosome membrane; lumenal side of endoplasmic reticulum membrane; lysosomal membrane; lysosome; membrane; MHC class II protein complex; plasma membrane; trans-Golgi network membrane; transport vesicle membrane","MHC II receptor activity","major histocompatibility complex, class II, DR alpha","http://www.ncbi.nlm.nih.gov/gene/?term=3122","3122",null,null,null,null,null,"P01903",null,"A0A8I6AUC1","A0A8I3NY87","A0A287AYL4","A0A1D5QT43","GO:0009986; GO:0030669; GO:0031410; GO:0031901; GO:0030666; GO:0005783; GO:0005789; GO:0005768; GO:0012507; GO:0070062; GO:0000139; GO:0001772; GO:0031902; GO:0098553; GO:0005765; GO:0005764; GO:0016020; GO:0042613; GO:0005886; GO:0032588; GO:0030658","GO:0023026; GO:0032395; GO:0042605; GO:0030247; GO:0005515; GO:0042608","GO:0002250; GO:0019882; GO:0002491; GO:0019886; GO:0002504; GO:0050890; GO:0006955; GO:0002376; GO:0002469; GO:0002503; GO:2000516; GO:0032831; GO:0043382; GO:0050870; GO:0001916; GO:0045622","PTHR19944:SF86","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4947|UniProtKB=P01903","P00053"]
["HLA-G",null,"HLA-G","38","ms",null,4,1,"n/a","n/a","n/a","n/a","# 0600",".ANG., .CANCER., .CSP., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TCD., .TCR., .TMAT., .TRASR.",null,"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G","antigen processing and presentation of endogenous peptide antigen via MHC class Ib; antigen processing and presentation of peptide antigen via MHC class I; cellular defense response; immune response-inhibiting cell surface receptor signaling pathway; immune system process; negative regulation of angiogenesis; negative regulation of dendritic cell differentiation; negative regulation of G0 to G1 transition; negative regulation of immune response; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of protein kinase B signaling; negative regulation of T cell mediated cytotoxicity; negative regulation of T cell proliferation; peripheral B cell tolerance induction; positive regulation of cellular senescence; positive regulation of endothelial cell apoptotic process; positive regulation of interleukin-12 production; positive regulation of macrophage cytokine production; positive regulation of natural killer cell cytokine production; positive regulation of regulatory T cell differentiation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction; protection from natural killer cell mediated cytotoxicity; protein homotrimerization","CD8 receptor binding; identical protein binding; peptide antigen binding; protein binding; protein homodimerization activity; signaling receptor binding","cell projection; cis-Golgi network membrane; early endosome; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; ER to Golgi transport vesicle membrane; external side of plasma membrane; extracellular region; extracellular space; filopodium membrane; Golgi membrane; lumenal side of endoplasmic reticulum membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane; recycling endosome membrane","MHC I receptor activity","major histocompatibility complex, class I, G","http://www.ncbi.nlm.nih.gov/gene/?term=3135","3135",null,"414784",null,null,null,"P17693",null,"Q4G002",null,"A0A287AAB2",null,"GO:0042995; GO:0033106; GO:0005769; GO:0031901; GO:0005783; GO:0005789; GO:0005768; GO:0012507; GO:0009897; GO:0005576; GO:0005615; GO:0031527; GO:0000139; GO:0098553; GO:0016020; GO:0042612; GO:0030670; GO:0005886; GO:0055038","GO:0042610; GO:0042802; GO:0042605; GO:0005515; GO:0042803; GO:0005102","GO:0002476; GO:0002474; GO:0006968; GO:0002767; GO:0002376; GO:0016525; GO:2001199; GO:0070317; GO:0050777; GO:0045953; GO:0051898; GO:0001915; GO:0042130; GO:0002451; GO:2000774; GO:2000353; GO:0032735; GO:0060907; GO:0002729; GO:0045591; GO:0002666; GO:0002645; GO:0042270; GO:0070207","PTHR16675:SF169","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4964|UniProtKB=P17693"]
["HMGCR",null,"HMGCR","98","rb",null,2,7,7,7,2.1,2,"# 1126",".AMPK., .CSP., .MAPK., .RTK., .SREME.","Cholesterol biosynthesis","3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE","cholesterol biosynthetic process; cholesterol metabolic process; coenzyme A metabolic process; isoprenoid biosynthetic process; lipid metabolic process; negative regulation of amyloid-beta clearance; negative regulation of MAP kinase activity; negative regulation of protein catabolic process; negative regulation of protein secretion; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process; visual learning","coenzyme A binding; hydroxymethylglutaryl-CoA reductase (NADPH) activity; NADP binding; NADPH binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding","endoplasmic reticulum; endoplasmic reticulum membrane; membrane; peroxisomal membrane; peroxisome","Metabolism","3-hydroxy-3-methylglutaryl-CoA reductase","http://www.ncbi.nlm.nih.gov/gene/?term=3156","3156","15357",null,null,null,null,"P04035","Q01237","A0A8I6A6Z9","A0A8I3NLM4","A0A287A061","F7HJ02","GO:0005783; GO:0005789; GO:0016020; GO:0005778; GO:0005777","GO:0120225; GO:0004420; GO:0050661; GO:0070402; GO:0016491; GO:0016616; GO:0005515","GO:0006695; GO:0008203; GO:0015936; GO:0008299; GO:0006629; GO:1900222; GO:0043407; GO:0042177; GO:0050709; GO:0006694; GO:0008202; GO:0016126; GO:0008542","PTHR10572:SF24","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5006|UniProtKB=P04035","P00014"]
["HMGCS1",null,"HMGCS1","57","rb",null,2,1,1,1,1,1,"# 1127",null,"Cholesterol biosynthesis","HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC","acetyl-CoA metabolic process; cholesterol biosynthetic process; cholesterol metabolic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; lipid metabolic process; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process","acyltransferase activity; hydroxymethylglutaryl-CoA synthase activity; protein homodimerization activity; transferase activity","cytoplasm; cytosol","Metabolism","3-hydroxy-3-methylglutaryl-CoA synthase 1","http://www.ncbi.nlm.nih.gov/gene/?term=3157","3157","208715","29637","479344",null,"702553","Q01581","Q8JZK9","P17425","A0A8I3MM03","A0A287BNA5","F7HQ90","GO:0005737; GO:0005829","GO:0016746; GO:0004421; GO:0042803; GO:0016740","GO:0006084; GO:0006695; GO:0008203; GO:0010142; GO:0008299; GO:0006629; GO:0006694; GO:0008202; GO:0016126","PTHR43323:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5007|UniProtKB=Q01581","P00014"]
["HNF-1 alpha (HNF-1A)",null,"HNF1A","67","rb",null,2,3,2,2,2,2,"# 1563",".OP., .OT., .TRASR.",null,"HEPATOCYTE NUCLEAR FACTOR 1-ALPHA","glucose homeostasis; glucose import; insulin secretion; liver development; pancreas development; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; regulation of pronephros size; regulation of transcription by RNA polymerase II; renal glucose absorption","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; nucleus; protein-containing complex","Transcription regulation","HNF1 homeobox A","http://www.ncbi.nlm.nih.gov/gene/?term=6927","6927","21405","24817",null,"574067",null,"P20823","P22361","P15257","A0A8I3SCK3","Q4PJJ8","A0A1D5Q4G4","GO:0000785; GO:0005737; GO:0005634; GO:0032991","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0046983; GO:0000978; GO:0000976","GO:0042593; GO:0046323; GO:0030073; GO:0001889; GO:0031016; GO:0045893; GO:0045944; GO:0060261; GO:0035565; GO:0006357; GO:0035623","PTHR11568:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11621|UniProtKB=P20823"]
["HNF-4 alpha (HNF-4A)",null,"HNF4A","52","rb",null,2,6,"n/a","n/a","n/a","n/a","# 1846",".AMPK., .CCP., .CP., .CSP., .DEV., .DRR., .OP., .OPA., .OT., .PLAT., .SREME., .ST., .TGFB., .TRASR.",null,"HEPATOCYTE NUCLEAR FACTOR 4-ALPHA","anatomical structure development; blood coagulation; cell differentiation; cholesterol homeostasis; glucose homeostasis; intracellular receptor signaling pathway; lipid homeostasis; lipid metabolic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; ornithine metabolic process; phospholipid homeostasis; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of gastrulation; regulation of insulin secretion; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; response to glucose; rhythmic process; sex differentiation; signal transduction involved in regulation of gene expression; SMAD protein signal transduction; transcription by RNA polymerase II; triglyceride homeostasis; xenobiotic metabolic process","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; fatty acid binding; metal ion binding; nuclear receptor activity; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; signaling receptor binding; transcription cis-regulatory region binding; zinc ion binding","chromatin; cytoplasm; nucleoplasm; nucleus",null,"hepatocyte nuclear factor 4 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=3172","3172","15378","25735",null,null,"717972","P41235","P49698","A0A0G2K0G1","A0A8I3NQV8","A0A287B2X7","F7HBP3","GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005504; GO:0046872; GO:0004879; GO:0005515; GO:0042803; GO:0000978; GO:0061629; GO:0043565; GO:1990837; GO:0005102; GO:0000976; GO:0008270","GO:0048856; GO:0007596; GO:0030154; GO:0042632; GO:0042593; GO:0030522; GO:0055088; GO:0006629; GO:0030308; GO:0008285; GO:0045892; GO:0006591; GO:0055091; GO:0045893; GO:0045944; GO:0042752; GO:0006355; GO:0010470; GO:0050796; GO:0019216; GO:0006357; GO:0009749; GO:0048511; GO:0007548; GO:0023019; GO:0060395; GO:0006366; GO:0070328; GO:0006805","PTHR24083:SF41","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5024|UniProtKB=P41235"]
["HNF-4 alpha (HNF-4A) - phospho","Ser142","HNF4A","52","rb",null,2.1,2.1,8,8,4,4,"# 1289",".AMPK., .CCP., .CP., .CSP., .DEV., .DRR., .OP., .OPA., .OT., .PLAT., .SREME., .ST., .TGFB., .TRASR.",null,"HEPATOCYTE NUCLEAR FACTOR 4-ALPHA","anatomical structure development; blood coagulation; cell differentiation; cholesterol homeostasis; glucose homeostasis; intracellular receptor signaling pathway; lipid homeostasis; lipid metabolic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; ornithine metabolic process; phospholipid homeostasis; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of gastrulation; regulation of insulin secretion; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; response to glucose; rhythmic process; sex differentiation; signal transduction involved in regulation of gene expression; SMAD protein signal transduction; transcription by RNA polymerase II; triglyceride homeostasis; xenobiotic metabolic process","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; fatty acid binding; metal ion binding; nuclear receptor activity; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; signaling receptor binding; transcription cis-regulatory region binding; zinc ion binding","chromatin; cytoplasm; nucleoplasm; nucleus","Transcription regulation","hepatocyte nuclear factor 4 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=3172","3172","15378","25735",null,null,"717972","P41235","P49698","A0A0G2K0G1","A0A8I3NQV8","A0A287B2X7","F7HBP3","GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005504; GO:0046872; GO:0004879; GO:0005515; GO:0042803; GO:0000978; GO:0061629; GO:0043565; GO:1990837; GO:0005102; GO:0000976; GO:0008270","GO:0048856; GO:0007596; GO:0030154; GO:0042632; GO:0042593; GO:0030522; GO:0055088; GO:0006629; GO:0030308; GO:0008285; GO:0045892; GO:0006591; GO:0055091; GO:0045893; GO:0045944; GO:0042752; GO:0006355; GO:0010470; GO:0050796; GO:0019216; GO:0006357; GO:0009749; GO:0048511; GO:0007548; GO:0023019; GO:0060395; GO:0006366; GO:0070328; GO:0006805","PTHR24083:SF41","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5024|UniProtKB=P41235"]
["HNF-4 alpha (HNF-4A) - phospho","Ser304","HNF4A","52","rb",null,2,2,2,6,2,2,"# 1292",".AMPK., .CCP., .CP., .CSP., .DEV., .DRR., .OP., .OPA., .OT., .PLAT., .SREME., .ST., .TGFB., .TRASR.",null,"HEPATOCYTE NUCLEAR FACTOR 4-ALPHA","anatomical structure development; blood coagulation; cell differentiation; cholesterol homeostasis; glucose homeostasis; intracellular receptor signaling pathway; lipid homeostasis; lipid metabolic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; ornithine metabolic process; phospholipid homeostasis; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of gastrulation; regulation of insulin secretion; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; response to glucose; rhythmic process; sex differentiation; signal transduction involved in regulation of gene expression; SMAD protein signal transduction; transcription by RNA polymerase II; triglyceride homeostasis; xenobiotic metabolic process","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; fatty acid binding; metal ion binding; nuclear receptor activity; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; signaling receptor binding; transcription cis-regulatory region binding; zinc ion binding","chromatin; cytoplasm; nucleoplasm; nucleus","Transcription regulation","hepatocyte nuclear factor 4 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=3172","3172","15378","25735",null,null,"717972","P41235","P49698","A0A0G2K0G1","A0A8I3NQV8","A0A287B2X7","F7HBP3","GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005504; GO:0046872; GO:0004879; GO:0005515; GO:0042803; GO:0000978; GO:0061629; GO:0043565; GO:1990837; GO:0005102; GO:0000976; GO:0008270","GO:0048856; GO:0007596; GO:0030154; GO:0042632; GO:0042593; GO:0030522; GO:0055088; GO:0006629; GO:0030308; GO:0008285; GO:0045892; GO:0006591; GO:0055091; GO:0045893; GO:0045944; GO:0042752; GO:0006355; GO:0010470; GO:0050796; GO:0019216; GO:0006357; GO:0009749; GO:0048511; GO:0007548; GO:0023019; GO:0060395; GO:0006366; GO:0070328; GO:0006805","PTHR24083:SF41","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5024|UniProtKB=P41235"]
["HNF-4 alpha (HNF-4A) - phospho","Ser313","HNF4A","50","rb",null,2,2,6,2,2,2,"# 1298",".AMPK., .CCP., .CP., .CSP., .DEV., .DRR., .OP., .OPA., .OT., .PLAT., .SREME., .ST., .TGFB., .TRASR.",null,"HEPATOCYTE NUCLEAR FACTOR 4-ALPHA","anatomical structure development; blood coagulation; cell differentiation; cholesterol homeostasis; glucose homeostasis; intracellular receptor signaling pathway; lipid homeostasis; lipid metabolic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; ornithine metabolic process; phospholipid homeostasis; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of gastrulation; regulation of insulin secretion; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; response to glucose; rhythmic process; sex differentiation; signal transduction involved in regulation of gene expression; SMAD protein signal transduction; transcription by RNA polymerase II; triglyceride homeostasis; xenobiotic metabolic process","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; fatty acid binding; metal ion binding; nuclear receptor activity; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; signaling receptor binding; transcription cis-regulatory region binding; zinc ion binding","chromatin; cytoplasm; nucleoplasm; nucleus","Transcription regulation","hepatocyte nuclear factor 4 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=3172","3172","15378","25735",null,null,"717972","P41235","P49698","A0A0G2K0G1","A0A8I3NQV8","A0A287B2X7","F7HBP3","GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005504; GO:0046872; GO:0004879; GO:0005515; GO:0042803; GO:0000978; GO:0061629; GO:0043565; GO:1990837; GO:0005102; GO:0000976; GO:0008270","GO:0048856; GO:0007596; GO:0030154; GO:0042632; GO:0042593; GO:0030522; GO:0055088; GO:0006629; GO:0030308; GO:0008285; GO:0045892; GO:0006591; GO:0055091; GO:0045893; GO:0045944; GO:0042752; GO:0006355; GO:0010470; GO:0050796; GO:0019216; GO:0006357; GO:0009749; GO:0048511; GO:0007548; GO:0023019; GO:0060395; GO:0006366; GO:0070328; GO:0006805","PTHR24083:SF41","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5024|UniProtKB=P41235"]
["hnRNPA1",null,"HNRNPA1","40, 34","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2201",".OP., .OT., .TRASR.",null,"HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1-RELATED","amyloid fibril formation; cellular response to glucose starvation; cellular response to sodium arsenite; import into nucleus; localization; mRNA processing; mRNA splicing, via spliceosome; mRNA transport; negative regulation of telomere maintenance via telomerase; nuclear export; positive regulation of telomere maintenance via telomerase; regulation of alternative mRNA splicing, via spliceosome; regulation of RNA splicing; RNA export from nucleus; RNA splicing","DNA binding; G-rich strand telomeric DNA binding; miRNA binding; molecular condensate scaffold activity; mRNA 3'-UTR binding; nucleic acid binding; pre-mRNA binding; protein binding; protein domain specific binding; RNA binding; single-stranded DNA binding; single-stranded RNA binding; telomeric repeat-containing RNA binding","catalytic step 2 spliceosome; cytoplasm; cytosol; extracellular exosome; intracellular non-membrane-bounded organelle; membrane; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex",null,"heterogeneous nuclear ribonucleoprotein A1","http://www.ncbi.nlm.nih.gov/gene/?term=3178","3178","15382",null,null,"768103",null,"P09651","P49312","A0A0G2K968","A0A8I3P181","A0A286ZPE3","F7HRD5","GO:0071013; GO:0005737; GO:0005829; GO:0070062; GO:0043232; GO:0016020; GO:0005654; GO:0005634; GO:1990904; GO:0005681","GO:0003677; GO:0098505; GO:0035198; GO:0140693; GO:0003730; GO:0003676; GO:0036002; GO:0005515; GO:0019904; GO:0003723; GO:0003697; GO:0003727; GO:0061752","GO:1990000; GO:0042149; GO:1903936; GO:0051170; GO:0051179; GO:0006397; GO:0000398; GO:0051028; GO:0032211; GO:0051168; GO:0032212; GO:0000381; GO:0043484; GO:0006405; GO:0008380","PTHR48026:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5031|UniProtKB=P09651"]
["HPK1",null,"MAP4K1","97","rb",null,2,6,"n/a","n/a","n/a","n/a","# 1956",".APO., .CCP., .CD., .CP., .CSP., .JNK., .MAPK., .OP., .OPA., .RTK., .SREME., .ST.","Gonadotropin releasing hormone receptor pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1","cell population proliferation; cellular response to phorbol 13-acetate 12-myristate; intracellular signal transduction; JNK cascade; peptidyl-serine phosphorylation; phosphorylation; positive regulation of MAPK cascade; protein autophosphorylation; protein phosphorylation","ATP binding; kinase activity; MAP kinase kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; membrane",null,"mitogen-activated protein kinase kinase kinase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=11184","11184","26411",null,null,null,null,"Q92918","P70218","A0A8I6A6A3","A0A8I3MYX9","A0A287AZW8","A0A1D5R952","GO:0005737; GO:0016020","GO:0005524; GO:0016301; GO:0008349; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0008283; GO:1904628; GO:0035556; GO:0007254; GO:0018105; GO:0016310; GO:0043410; GO:0046777; GO:0006468","PTHR48012:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6863|UniProtKB=Q92918","P06664; P00006"]
["HPK1 - phospho","Ser171","MAP4K1","90","rb",null,6,2,"n/a","n/a","n/a","n/a","# 2265",".APO., .CCP., .CD., .CP., .CSP., .JNK., .MAPK., .OP., .OPA., .RTK., .SREME., .ST.","Gonadotropin releasing hormone receptor pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1","cell population proliferation; cellular response to phorbol 13-acetate 12-myristate; intracellular signal transduction; JNK cascade; peptidyl-serine phosphorylation; phosphorylation; positive regulation of MAPK cascade; protein autophosphorylation; protein phosphorylation","ATP binding; kinase activity; MAP kinase kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; membrane",null,"mitogen-activated protein kinase kinase kinase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=11184","11184","26411",null,null,null,null,"Q92918","P70218","A0A8I6A6A3","A0A8I3MYX9","A0A287AZW8","A0A1D5R952","GO:0005737; GO:0016020","GO:0005524; GO:0016301; GO:0008349; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0008283; GO:1904628; GO:0035556; GO:0007254; GO:0018105; GO:0016310; GO:0043410; GO:0046777; GO:0006468","PTHR48012:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6863|UniProtKB=Q92918","P06664; P00006"]
["HPK1 - phospho","Thr165","MAP4K1","91","rb",null,2,6,"n/a","n/a","n/a","n/a","# 2254",".APO., .CCP., .CD., .CP., .CSP., .JNK., .MAPK., .OP., .OPA., .RTK., .SREME., .ST.","Gonadotropin releasing hormone receptor pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1","cell population proliferation; cellular response to phorbol 13-acetate 12-myristate; intracellular signal transduction; JNK cascade; peptidyl-serine phosphorylation; phosphorylation; positive regulation of MAPK cascade; protein autophosphorylation; protein phosphorylation","ATP binding; kinase activity; MAP kinase kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; membrane",null,"mitogen-activated protein kinase kinase kinase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=11184","11184","26411",null,null,null,null,"Q92918","P70218","A0A8I6A6A3","A0A8I3MYX9","A0A287AZW8","A0A1D5R952","GO:0005737; GO:0016020","GO:0005524; GO:0016301; GO:0008349; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0008283; GO:1904628; GO:0035556; GO:0007254; GO:0018105; GO:0016310; GO:0043410; GO:0046777; GO:0006468","PTHR48012:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6863|UniProtKB=Q92918","P06664; P00006"]
["HSF1",null,"HSF1","82","rb",null,2,4,4,4,4,4,"# 0249",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .DRR., .HIF., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .STAT., .TRASR.",null,"HEAT SHOCK FACTOR PROTEIN 1","cellular response to amino acid stimulus; cellular response to angiotensin; cellular response to cadmium ion; cellular response to copper ion; cellular response to diamide; cellular response to DNA damage stimulus; cellular response to estradiol stimulus; cellular response to gamma radiation; cellular response to heat; cellular response to hydrogen peroxide; cellular response to L-glutamine; cellular response to lipopolysaccharide; cellular response to nitroglycerin; cellular response to organic cyclic compound; cellular response to potassium ion; cellular response to radiation; cellular response to sodium arsenite; cellular response to unfolded protein; cellular response to xenobiotic stimulus; defense response; DNA repair; MAPK cascade; mRNA processing; mRNA transcription; mRNA transport; negative regulation of cardiac muscle cell apoptotic process; negative regulation of double-strand break repair via nonhomologous end joining; negative regulation of gene expression; negative regulation of inclusion body assembly; negative regulation of neuron death; negative regulation of protein-containing complex assembly; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic DNA fragmentation; positive regulation of cold-induced thermogenesis; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression; positive regulation of inclusion body assembly; positive regulation of macrophage differentiation; positive regulation of microtubule binding; positive regulation of mitotic cell cycle; positive regulation of mRNA polyadenylation; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; protein-containing complex assembly; regulation of cellular response to heat; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to activity; response to amino acid; response to estradiol; response to heat; response to hypobaric hypoxia; response to nutrient; response to organic cyclic compound; response to organonitrogen compound; response to peptide; response to psychosocial stress; response to testosterone","chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; general transcription initiation factor binding; heat shock protein binding; Hsp90 protein binding; identical protein binding; promoter-specific chromatin binding; protein binding; protein heterodimerization activity; protein kinase binding; protein self-association; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; sequence-specific single stranded DNA binding; STAT family protein binding; transcription cis-regulatory region binding; translation elongation factor binding","centrosome; chaperone complex; chromatin; chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; euchromatin; heterochromatin; kinetochore; microtubule organizing center; mitotic spindle pole; nuclear stress granule; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body; ribonucleoprotein complex; spindle pole","Protein folding","heat shock transcription factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=3297","3297","15499",null,null,null,null,"Q00613","P38532","A0A8I5Y5J6","A0A8I3N2P1","A0A286ZSP4","A0A1D5Q735","GO:0005813; GO:0101031; GO:0000785; GO:0005694; GO:0000775; GO:0005737; GO:0005856; GO:0005829; GO:0000791; GO:0000792; GO:0000776; GO:0005815; GO:0097431; GO:0097165; GO:0005654; GO:0005634; GO:0048471; GO:0016605; GO:1990904; GO:0000922","GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0140296; GO:0031072; GO:0051879; GO:0042802; GO:1990841; GO:0005515; GO:0046982; GO:0019901; GO:0043621; GO:0000978; GO:0001162; GO:0043565; GO:1990837; GO:0098847; GO:0097677; GO:0000976; GO:0061770","GO:0071230; GO:1904385; GO:0071276; GO:0071280; GO:0072738; GO:0006974; GO:0071392; GO:0071480; GO:0034605; GO:0070301; GO:1904845; GO:0071222; GO:1904843; GO:0071407; GO:0035865; GO:0071478; GO:1903936; GO:0034620; GO:0071466; GO:0006952; GO:0006281; GO:0000165; GO:0006397; GO:0009299; GO:0051028; GO:0010667; GO:2001033; GO:0010629; GO:0090084; GO:1901215; GO:0031333; GO:0000122; GO:1902512; GO:0120162; GO:0043280; GO:0051091; GO:0010628; GO:0090261; GO:0045651; GO:1904528; GO:0045931; GO:1900365; GO:0045944; GO:0042531; GO:0065003; GO:1900034; GO:0006355; GO:0006357; GO:0014823; GO:0043200; GO:0032355; GO:0009408; GO:1990910; GO:0007584; GO:0014070; GO:0010243; GO:1901652; GO:1990911; GO:0033574","PTHR10015:SF274","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5224|UniProtKB=Q00613"]
["HSF1 - phospho","Ser326","HSF1","82","rb",null,2,4,4,4,4,4,"# 0251",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .DRR., .HIF., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .STAT., .TRASR.",null,"HEAT SHOCK FACTOR PROTEIN 1","cellular response to amino acid stimulus; cellular response to angiotensin; cellular response to cadmium ion; cellular response to copper ion; cellular response to diamide; cellular response to DNA damage stimulus; cellular response to estradiol stimulus; cellular response to gamma radiation; cellular response to heat; cellular response to hydrogen peroxide; cellular response to L-glutamine; cellular response to lipopolysaccharide; cellular response to nitroglycerin; cellular response to organic cyclic compound; cellular response to potassium ion; cellular response to radiation; cellular response to sodium arsenite; cellular response to unfolded protein; cellular response to xenobiotic stimulus; defense response; DNA repair; MAPK cascade; mRNA processing; mRNA transcription; mRNA transport; negative regulation of cardiac muscle cell apoptotic process; negative regulation of double-strand break repair via nonhomologous end joining; negative regulation of gene expression; negative regulation of inclusion body assembly; negative regulation of neuron death; negative regulation of protein-containing complex assembly; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic DNA fragmentation; positive regulation of cold-induced thermogenesis; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression; positive regulation of inclusion body assembly; positive regulation of macrophage differentiation; positive regulation of microtubule binding; positive regulation of mitotic cell cycle; positive regulation of mRNA polyadenylation; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; protein-containing complex assembly; regulation of cellular response to heat; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to activity; response to amino acid; response to estradiol; response to heat; response to hypobaric hypoxia; response to nutrient; response to organic cyclic compound; response to organonitrogen compound; response to peptide; response to psychosocial stress; response to testosterone","chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; general transcription initiation factor binding; heat shock protein binding; Hsp90 protein binding; identical protein binding; promoter-specific chromatin binding; protein binding; protein heterodimerization activity; protein kinase binding; protein self-association; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; sequence-specific single stranded DNA binding; STAT family protein binding; transcription cis-regulatory region binding; translation elongation factor binding","centrosome; chaperone complex; chromatin; chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; euchromatin; heterochromatin; kinetochore; microtubule organizing center; mitotic spindle pole; nuclear stress granule; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body; ribonucleoprotein complex; spindle pole","Protein folding","heat shock transcription factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=3297","3297","15499",null,null,null,null,"Q00613","P38532","A0A8I5Y5J6","A0A8I3N2P1","A0A286ZSP4","A0A1D5Q735","GO:0005813; GO:0101031; GO:0000785; GO:0005694; GO:0000775; GO:0005737; GO:0005856; GO:0005829; GO:0000791; GO:0000792; GO:0000776; GO:0005815; GO:0097431; GO:0097165; GO:0005654; GO:0005634; GO:0048471; GO:0016605; GO:1990904; GO:0000922","GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0140296; GO:0031072; GO:0051879; GO:0042802; GO:1990841; GO:0005515; GO:0046982; GO:0019901; GO:0043621; GO:0000978; GO:0001162; GO:0043565; GO:1990837; GO:0098847; GO:0097677; GO:0000976; GO:0061770","GO:0071230; GO:1904385; GO:0071276; GO:0071280; GO:0072738; GO:0006974; GO:0071392; GO:0071480; GO:0034605; GO:0070301; GO:1904845; GO:0071222; GO:1904843; GO:0071407; GO:0035865; GO:0071478; GO:1903936; GO:0034620; GO:0071466; GO:0006952; GO:0006281; GO:0000165; GO:0006397; GO:0009299; GO:0051028; GO:0010667; GO:2001033; GO:0010629; GO:0090084; GO:1901215; GO:0031333; GO:0000122; GO:1902512; GO:0120162; GO:0043280; GO:0051091; GO:0010628; GO:0090261; GO:0045651; GO:1904528; GO:0045931; GO:1900365; GO:0045944; GO:0042531; GO:0065003; GO:1900034; GO:0006355; GO:0006357; GO:0014823; GO:0043200; GO:0032355; GO:0009408; GO:1990910; GO:0007584; GO:0014070; GO:0010243; GO:1901652; GO:1990911; GO:0033574","PTHR10015:SF274","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5224|UniProtKB=Q00613"]
["HSF2",null,"HSF2","60","rb",null,2.1,4,"n/a","n/a","n/a","n/a","# 0250",".OP., .OT., .TRASR.",null,"HEAT SHOCK FACTOR PROTEIN 2","positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; spermatogenesis","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; cytoplasm; nucleoplasm; nucleus","Protein folding","heat shock transcription factor 2","http://www.ncbi.nlm.nih.gov/gene/?term=3298","3298","15500","64441",null,"100154234","713938","Q03933","P38533","A0A8I5ZYL7","A0A8I3N6Q0","A0A287AEZ2","F6PRI6","GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0000978; GO:0001162; GO:0000977; GO:0043565; GO:1990837","GO:0045944; GO:0006355; GO:0006357; GO:0007283","PTHR10015:SF185","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5225|UniProtKB=Q03933"]
["HSP 27",null,"HSPB1","27","ms",null,1,4,2,8,2,8.1,"# 2646",".ANG., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS., .VIR.","CCKR signaling map; p38 MAPK pathway; VEGF signaling pathway; Angiogenesis","HEAT SHOCK PROTEIN BETA-1","anterograde axonal protein transport; cellular response to vascular endothelial growth factor stimulus; chaperone-mediated protein folding; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein kinase activity; platelet aggregation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of tumor necrosis factor production; protein refolding; regulation of autophagy; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of protein phosphorylation; regulation of translational initiation; response to heat; response to unfolded protein; response to virus; retina homeostasis","identical protein binding; protein binding; protein folding chaperone; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein kinase C inhibitor activity; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; ubiquitin binding; unfolded protein binding","axon cytoplasm; contractile fiber; cornified envelope; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular space; focal adhesion; nucleus; plasma membrane; proteasome complex; spindle; Z disc","Protein folding / chaperone","heat shock protein family B (small) member 1","http://www.ncbi.nlm.nih.gov/gene/?term=3315","3315","15507","24471",null,null,null,"P04792","P14602","G3V913","A0A8P0NFA6",null,null,"GO:1904115; GO:0043292; GO:0001533; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005615; GO:0005925; GO:0005634; GO:0005886; GO:0000502; GO:0005819; GO:0030018","GO:0042802; GO:0005515; GO:0044183; GO:0042803; GO:0019901; GO:0005080; GO:0008426; GO:0003723; GO:0061629; GO:0043130; GO:0051082","GO:0099641; GO:0035924; GO:0061077; GO:0035556; GO:0043066; GO:2001234; GO:1902176; GO:0006469; GO:0070527; GO:0045766; GO:0043536; GO:2001028; GO:0038033; GO:0032731; GO:0032760; GO:0042026; GO:0010506; GO:0043122; GO:0001932; GO:0006446; GO:0009408; GO:0006986; GO:0009615; GO:0001895","PTHR45640:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5246|UniProtKB=P04792","P06959; P05918; P00056; P00005"]
["HSP 27 - phospho","Ser15","HSPB1","27","rb",null,2,4,8,8,1,8,"# 0208",".ANG., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS., .VIR.","CCKR signaling map; p38 MAPK pathway; VEGF signaling pathway; Angiogenesis","HEAT SHOCK PROTEIN BETA-1","anterograde axonal protein transport; cellular response to vascular endothelial growth factor stimulus; chaperone-mediated protein folding; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein kinase activity; platelet aggregation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of tumor necrosis factor production; protein refolding; regulation of autophagy; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of protein phosphorylation; regulation of translational initiation; response to heat; response to unfolded protein; response to virus; retina homeostasis","identical protein binding; protein binding; protein folding chaperone; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein kinase C inhibitor activity; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; ubiquitin binding; unfolded protein binding","axon cytoplasm; contractile fiber; cornified envelope; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular space; focal adhesion; nucleus; plasma membrane; proteasome complex; spindle; Z disc","Protein folding / chaperone","heat shock protein family B (small) member 1","http://www.ncbi.nlm.nih.gov/gene/?term=3315","3315","15507","24471",null,null,null,"P04792","P14602","G3V913","A0A8P0NFA6",null,null,"GO:1904115; GO:0043292; GO:0001533; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005615; GO:0005925; GO:0005634; GO:0005886; GO:0000502; GO:0005819; GO:0030018","GO:0042802; GO:0005515; GO:0044183; GO:0042803; GO:0019901; GO:0005080; GO:0008426; GO:0003723; GO:0061629; GO:0043130; GO:0051082","GO:0099641; GO:0035924; GO:0061077; GO:0035556; GO:0043066; GO:2001234; GO:1902176; GO:0006469; GO:0070527; GO:0045766; GO:0043536; GO:2001028; GO:0038033; GO:0032731; GO:0032760; GO:0042026; GO:0010506; GO:0043122; GO:0001932; GO:0006446; GO:0009408; GO:0006986; GO:0009615; GO:0001895","PTHR45640:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5246|UniProtKB=P04792","P06959; P05918; P00056; P00005"]
["HSP 27 - phospho","Ser78","HSPB1","27","rb",null,2,4,1.1000000000000001,1.1000000000000001,8,8,"# 0346",".ANG., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS., .VIR.","CCKR signaling map; p38 MAPK pathway; VEGF signaling pathway; Angiogenesis","HEAT SHOCK PROTEIN BETA-1","anterograde axonal protein transport; cellular response to vascular endothelial growth factor stimulus; chaperone-mediated protein folding; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein kinase activity; platelet aggregation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of tumor necrosis factor production; protein refolding; regulation of autophagy; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of protein phosphorylation; regulation of translational initiation; response to heat; response to unfolded protein; response to virus; retina homeostasis","identical protein binding; protein binding; protein folding chaperone; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein kinase C inhibitor activity; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; ubiquitin binding; unfolded protein binding","axon cytoplasm; contractile fiber; cornified envelope; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular space; focal adhesion; nucleus; plasma membrane; proteasome complex; spindle; Z disc","Protein folding / chaperone","heat shock protein family B (small) member 1","http://www.ncbi.nlm.nih.gov/gene/?term=3315","3315","15507","24471",null,null,null,"P04792","P14602","G3V913","A0A8P0NFA6",null,null,"GO:1904115; GO:0043292; GO:0001533; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005615; GO:0005925; GO:0005634; GO:0005886; GO:0000502; GO:0005819; GO:0030018","GO:0042802; GO:0005515; GO:0044183; GO:0042803; GO:0019901; GO:0005080; GO:0008426; GO:0003723; GO:0061629; GO:0043130; GO:0051082","GO:0099641; GO:0035924; GO:0061077; GO:0035556; GO:0043066; GO:2001234; GO:1902176; GO:0006469; GO:0070527; GO:0045766; GO:0043536; GO:2001028; GO:0038033; GO:0032731; GO:0032760; GO:0042026; GO:0010506; GO:0043122; GO:0001932; GO:0006446; GO:0009408; GO:0006986; GO:0009615; GO:0001895","PTHR45640:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5246|UniProtKB=P04792","P06959; P05918; P00056; P00005"]
["HSP 27 - phospho","Ser82","HSPB1","27","rb",null,2.1,4,4,7,6,8,"# 0345",".ANG., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS., .VIR.","CCKR signaling map; p38 MAPK pathway; VEGF signaling pathway; Angiogenesis","HEAT SHOCK PROTEIN BETA-1","anterograde axonal protein transport; cellular response to vascular endothelial growth factor stimulus; chaperone-mediated protein folding; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein kinase activity; platelet aggregation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of tumor necrosis factor production; protein refolding; regulation of autophagy; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of protein phosphorylation; regulation of translational initiation; response to heat; response to unfolded protein; response to virus; retina homeostasis","identical protein binding; protein binding; protein folding chaperone; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein kinase C inhibitor activity; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; ubiquitin binding; unfolded protein binding","axon cytoplasm; contractile fiber; cornified envelope; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular space; focal adhesion; nucleus; plasma membrane; proteasome complex; spindle; Z disc","Protein folding / chaperone","heat shock protein family B (small) member 1","http://www.ncbi.nlm.nih.gov/gene/?term=3315","3315","15507","24471",null,null,null,"P04792","P14602","G3V913","A0A8P0NFA6",null,null,"GO:1904115; GO:0043292; GO:0001533; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005615; GO:0005925; GO:0005634; GO:0005886; GO:0000502; GO:0005819; GO:0030018","GO:0042802; GO:0005515; GO:0044183; GO:0042803; GO:0019901; GO:0005080; GO:0008426; GO:0003723; GO:0061629; GO:0043130; GO:0051082","GO:0099641; GO:0035924; GO:0061077; GO:0035556; GO:0043066; GO:2001234; GO:1902176; GO:0006469; GO:0070527; GO:0045766; GO:0043536; GO:2001028; GO:0038033; GO:0032731; GO:0032760; GO:0042026; GO:0010506; GO:0043122; GO:0001932; GO:0006446; GO:0009408; GO:0006986; GO:0009615; GO:0001895","PTHR45640:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5246|UniProtKB=P04792","P06959; P05918; P00056; P00005"]
["HSP 90",null,"HSP90AA1","95","ms",null,2,2,"n/a","n/a","n/a","n/a","# 2793",".APH., .APO., .CANCER., .CANPTHW., .CD., .CSP., .DRR., .IMUR., .MIG., .OP., .OPA., .OT., .PI3K., .PRC., .RTK., .ST., .TCD., .TMAT., .UBI., .VIR.",null,"HEAT SHOCK PROTEIN HSP 90-ALPHA","activation of innate immune response; axon extension; cardiac muscle cell apoptotic process; cellular response to heat; cellular response to virus; central nervous system neuron axonogenesis; chaperone-mediated autophagy; chaperone-mediated protein complex assembly; establishment of cell polarity; mitochondrial transport; neuron migration; positive regulation of cardiac muscle contraction; positive regulation of cell size; positive regulation of defense response to virus by host; positive regulation of interferon-beta production; positive regulation of lamellipodium assembly; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein catabolic process; positive regulation of protein import into nucleus; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of protein polymerization; positive regulation of tau-protein kinase activity; positive regulation of telomerase activity; protein folding; protein insertion into mitochondrial outer membrane; protein refolding; protein stabilization; protein unfolding; regulation of apoptotic process; regulation of postsynaptic membrane neurotransmitter receptor levels; regulation of protein localization; regulation of protein ubiquitination; regulation of protein-containing complex assembly; response to antibiotic; response to cocaine; response to cold; response to estrogen; response to heat; response to salt stress; response to unfolded protein; response to xenobiotic stimulus; skeletal muscle contraction; telomerase holoenzyme complex assembly; telomere maintenance via telomerase","ATP binding; ATP hydrolysis activity; ATP-dependent protein folding chaperone; CTP binding; dATP binding; disordered domain specific binding; DNA polymerase binding; enzyme binding; GTP binding; GTPase binding; histone deacetylase binding; hydrolase activity; identical protein binding; MHC class II protein complex binding; mRNA binding; nitric-oxide synthase regulator activity; nucleotide binding; protein binding; protein folding chaperone; protein homodimerization activity; protein phosphatase binding; protein tyrosine kinase binding; Rho GDP-dissociation inhibitor binding; RNA binding; scaffold protein binding; sulfonylurea receptor binding; tau protein binding; TPR domain binding; transmembrane transporter binding; ubiquitin protein ligase binding; unfolded protein binding; UTP binding","apical plasma membrane; axonal growth cone; basolateral plasma membrane; brush border membrane; cell surface; collagen-containing extracellular matrix; cytoplasm; cytosol; dendritic growth cone; endocytic vesicle lumen; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; lysosomal lumen; melanosome; membrane; mitochondrion; myelin sheath; neuron projection; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; secretory granule lumen; sperm flagellum; sperm mitochondrial sheath; sperm plasma membrane","Protein folding / chaperone","heat shock protein 90 alpha family class A member 1","http://www.ncbi.nlm.nih.gov/gene/?term=3320","3320","15519","299331",null,null,null,"P07900","P07901","P82995","A0A8I3MR78","A0A287AQK7",null,"GO:0016324; GO:0044295; GO:0016323; GO:0031526; GO:0009986; GO:0062023; GO:0005737; GO:0005829; GO:0044294; GO:0071682; GO:0070062; GO:0005576; GO:1904813; GO:0043202; GO:0042470; GO:0016020; GO:0005739; GO:0043209; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0032991; GO:0034774; GO:0036126; GO:0097226; GO:0097524","GO:0005524; GO:0016887; GO:0140662; GO:0002135; GO:0032564; GO:0097718; GO:0070182; GO:0019899; GO:0005525; GO:0051020; GO:0042826; GO:0016787; GO:0042802; GO:0023026; GO:0003729; GO:0030235; GO:0000166; GO:0005515; GO:0044183; GO:0042803; GO:0019903; GO:1990782; GO:0051022; GO:0003723; GO:0097110; GO:0017098; GO:0048156; GO:0030911; GO:0044325; GO:0031625; GO:0051082; GO:0002134","GO:0002218; GO:0048675; GO:0010659; GO:0034605; GO:0098586; GO:0021955; GO:0061684; GO:0051131; GO:0030010; GO:0006839; GO:0001764; GO:0060452; GO:0045793; GO:0002230; GO:0032728; GO:0010592; GO:0045429; GO:0033138; GO:0045732; GO:0042307; GO:0051897; GO:0001934; GO:0032273; GO:1902949; GO:0051973; GO:0006457; GO:0045040; GO:0042026; GO:0050821; GO:0043335; GO:0042981; GO:0099072; GO:0032880; GO:0031396; GO:0043254; GO:0046677; GO:0042220; GO:0009409; GO:0043627; GO:0009408; GO:0009651; GO:0006986; GO:0009410; GO:0003009; GO:1905323; GO:0007004","PTHR11528:SF87","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5253|UniProtKB=P07900"]
["HSP70",null,"HSPA1A","70","rb",null,1,1,8,1,1,1,"# 1858",".APO., .CCP., .CD., .CP., .CSP., .DEV., .DI., .IMUF., .IMUR., .INFM., .MAPK., .NFKB., .OP., .OT., .OXS., .PARK., .RTK., .SREME., .TGFB., .TNF., .TRASR., .UBI., .VIR.","Gonadotropin releasing hormone receptor pathway; Parkinson disease; Apoptosis signaling pathway","HEAT SHOCK 70 KDA PROTEIN 1A-RELATED","ATP metabolic process; cellular heat acclimation; cellular response to heat; cellular response to oxidative stress; cellular response to steroid hormone stimulus; cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; chaperone-mediated protein complex assembly; lysosomal transport; mRNA catabolic process; negative regulation of apoptotic process; negative regulation of cell death; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of inclusion body assembly; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; negative regulation of protein ubiquitination; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of endoribonuclease activity; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of interleukin-8 production; positive regulation of microtubule nucleation; positive regulation of NF-kappaB transcription factor activity; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of RNA splicing; positive regulation of tumor necrosis factor-mediated signaling pathway; protein refolding; protein stabilization; regulation of cell death; regulation of mitotic spindle assembly; regulation of protein ubiquitination; response to unfolded protein; vesicle-mediated transport; viral entry into host cell","ATP binding; ATP hydrolysis activity; ATP-dependent protein disaggregase activity; ATP-dependent protein folding chaperone; C3HC4-type RING finger domain binding; cadherin binding; denatured protein binding; disordered domain specific binding; enzyme binding; G protein-coupled receptor binding; heat shock protein binding; histone deacetylase binding; misfolded protein binding; nucleotide binding; protein binding; protein folding chaperone; protein N-terminus binding; RNA binding; signaling receptor binding; transcription corepressor activity; transcription regulator inhibitor activity; ubiquitin protein ligase binding; unfolded protein binding; virus receptor activity","aggresome; blood microparticle; centriole; centrosome; COP9 signalosome; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; focal adhesion; inclusion body; microtubule organizing center; mitochondrion; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; ribonucleoprotein complex; vesicle","Protein folding / chaperone","heat shock protein family A (Hsp70) member 1A","http://www.ncbi.nlm.nih.gov/gene/?term=3303","3303","193740",null,null,"100144518",null,"P0DMV8","Q61696","A0A8L2RAM6","A0A8P0N3U0","A5A8V7",null,"GO:0016235; GO:0072562; GO:0005814; GO:0005813; GO:0008180; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0070062; GO:0005576; GO:1904813; GO:0005925; GO:0016234; GO:0005815; GO:0005739; GO:0016607; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0032991; GO:1990904; GO:0031982","GO:0005524; GO:0016887; GO:0140545; GO:0140662; GO:0055131; GO:0045296; GO:0031249; GO:0097718; GO:0019899; GO:0001664; GO:0031072; GO:0042826; GO:0051787; GO:0000166; GO:0005515; GO:0044183; GO:0047485; GO:0003723; GO:0005102; GO:0003714; GO:0140416; GO:0031625; GO:0051082; GO:0001618","GO:0046034; GO:0070370; GO:0034605; GO:0034599; GO:0071383; GO:0034620; GO:0051085; GO:0051131; GO:0007041; GO:0006402; GO:0043066; GO:0060548; GO:0030308; GO:0008285; GO:1902236; GO:2001240; GO:0090084; GO:1901029; GO:0031397; GO:0000122; GO:0030512; GO:1902380; GO:0045648; GO:0010628; GO:0032757; GO:0090063; GO:0051092; GO:0070434; GO:0032436; GO:0033120; GO:1903265; GO:0042026; GO:0050821; GO:0010941; GO:1901673; GO:0031396; GO:0006986; GO:0016192; GO:0046718","PTHR19375:SF223","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5232|UniProtKB=P0DMV8","P06664; P00049; P00006"]
["IDH1",null,"IDH1","46","rb",null,2,1,1,1,1,1,"# 1316",".CAMET., .CANCER., .OP.",null,"ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC","2-oxoglutarate metabolic process; female gonad development; glutathione metabolic process; glyoxylate cycle; isocitrate metabolic process; NADP metabolic process; regulation of phospholipid biosynthetic process; regulation of phospholipid catabolic process; response to organic cyclic compound; response to oxidative stress; response to steroid hormone; tricarboxylic acid cycle","cadherin binding; identical protein binding; isocitrate dehydrogenase (NADP+) activity; magnesium ion binding; metal ion binding; NAD binding; NADP binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding; protein homodimerization activity","cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; mitochondrion; peroxisomal matrix; peroxisome; secretory granule lumen; tertiary granule lumen","Metabolism","isocitrate dehydrogenase (NADP(+)) 1","http://www.ncbi.nlm.nih.gov/gene/?term=3417","3417","15926","24479","478889",null,"710019","O75874","O88844","P41562","F1PZA1","A0A287A8M1","F7GN57","GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1904813; GO:0005739; GO:0005782; GO:0005777; GO:0034774; GO:1904724","GO:0045296; GO:0042802; GO:0004450; GO:0000287; GO:0046872; GO:0051287; GO:0050661; GO:0016491; GO:0016616; GO:0005515; GO:0042803","GO:0006103; GO:0008585; GO:0006749; GO:0006097; GO:0006102; GO:0006739; GO:0071071; GO:0060696; GO:0014070; GO:0006979; GO:0048545; GO:0006099","PTHR11822:SF28","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5382|UniProtKB=O75874"]
["IDH2",null,"IDH2","50","ms",null,2,2,2,1,2,2,"# 1137",".CAMET., .CANCER., .OP.",null,"ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL","2-oxoglutarate metabolic process; carbohydrate metabolic process; glyoxylate cycle; isocitrate metabolic process; NADP metabolic process; tricarboxylic acid cycle","isocitrate dehydrogenase (NADP+) activity; magnesium ion binding; metal ion binding; NAD binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","cytosol; extracellular exosome; mitochondrial matrix; mitochondrion; peroxisome","Metabolism","isocitrate dehydrogenase (NADP(+)) 2","http://www.ncbi.nlm.nih.gov/gene/?term=3418","3418","269951",null,null,null,null,"P48735","P54071","A0A0G2JUF6","A0A8P0NE04","A0A286ZYE6","F6VPY2","GO:0005829; GO:0070062; GO:0005759; GO:0005739; GO:0005777","GO:0004450; GO:0000287; GO:0046872; GO:0051287; GO:0016491; GO:0016616","GO:0006103; GO:0005975; GO:0006097; GO:0006102; GO:0006739; GO:0006099","PTHR11822:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5383|UniProtKB=P48735"]
["IGF1",null,"IGF1","22","rb",null,6,2,7,7,7,7,"# 1422",".AMPK., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .FOXO., .GLI., .HIF., .IMFR., .IMUF., .IMUR., .INS., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TCR., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway","INSULIN-LIKE GROWTH FACTOR I","activation of protein kinase B activity; bone mineralization involved in bone maturation; cell activation; cell population proliferation; cellular response to amyloid-beta; epithelial to mesenchymal transition; ERK1 and ERK2 cascade; glycolate metabolic process; insulin-like growth factor receptor signaling pathway; muscle hypertrophy; muscle organ development; myoblast differentiation; myoblast proliferation; myotube cell development; negative regulation of amyloid-beta formation; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of gene expression; negative regulation of interleukin-1 beta production; negative regulation of neuroinflammatory response; negative regulation of oocyte development; negative regulation of release of cytochrome c from mitochondria; negative regulation of smooth muscle cell apoptotic process; negative regulation of tumor necrosis factor production; negative regulation of vascular associated smooth muscle cell apoptotic process; phosphatidylinositol 3-kinase signaling; phosphatidylinositol-mediated signaling; positive regulation of activated T cell proliferation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle hypertrophy; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA binding; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of glycolytic process; positive regulation of glycoprotein biosynthetic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of mitotic nuclear division; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of protein secretion; positive regulation of Ras protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; positive regulation of trophectodermal cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular associated smooth muscle cell proliferation; protein kinase B signaling; protein stabilization; proteoglycan biosynthetic process; Ras protein signal transduction; regulation of gene expression; regulation of protein phosphorylation; response to heat; signal transduction; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; skeletal system development; wound healing","growth factor activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; integrin binding; protein binding","alphav-beta3 integrin-IGF-1-IGF1R complex; exocytic vesicle; extracellular region; extracellular space; insulin-like growth factor binding protein complex; insulin-like growth factor ternary complex; platelet alpha granule lumen","Insulin signaling","insulin like growth factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=3479","3479","16000","24482","610255","397491","698444","P05019","P05017","P08025","P33712","P16545","A0A1D5Q6C0","GO:0035867; GO:0070382; GO:0005576; GO:0005615; GO:0016942; GO:0042567; GO:0031093","GO:0008083; GO:0005179; GO:0005158; GO:0005159; GO:0005178; GO:0005515","GO:0032148; GO:0035630; GO:0001775; GO:0008283; GO:1904646; GO:0001837; GO:0070371; GO:0009441; GO:0048009; GO:0014896; GO:0007517; GO:0045445; GO:0051450; GO:0014904; GO:1902430; GO:0043066; GO:2001237; GO:0010629; GO:0032691; GO:0150079; GO:0060283; GO:0090201; GO:0034392; GO:0032720; GO:1905460; GO:0014065; GO:0048015; GO:0042104; GO:0070886; GO:0010613; GO:0061051; GO:0030335; GO:0008284; GO:0043388; GO:0045893; GO:0050679; GO:0070374; GO:0048146; GO:0010628; GO:0046326; GO:0045725; GO:0045821; GO:0010560; GO:0043568; GO:0043410; GO:0045840; GO:0045669; GO:0050731; GO:0014068; GO:0051897; GO:0050714; GO:0046579; GO:0014911; GO:0048661; GO:0045944; GO:2000679; GO:1904075; GO:0042531; GO:1904707; GO:0043491; GO:0050821; GO:0030166; GO:0007265; GO:0010468; GO:0001932; GO:0009408; GO:0007165; GO:0014834; GO:0001501; GO:0042060","PTHR46845:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5464|UniProtKB=P05019","P00032; P00033; P06664"]
["IGF-1R beta",null,"IGF1R","95","rb",null,2,4,1.1000000000000001,1.1000000000000001,1,1,"# 0448",".AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DMTOR., .DRR., .EGFR., .FOXO., .GLI., .HIF., .IMU., .IMUR., .INS., .JNK., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway","INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR","aging; amyloid-beta clearance; axonogenesis; cardiac atrium development; cellular response to aldosterone; cellular response to amyloid-beta; cellular response to angiotensin; cellular response to dexamethasone stimulus; cellular response to estradiol stimulus; cellular response to glucose stimulus; cellular response to insulin stimulus; cellular response to insulin-like growth factor stimulus; cellular response to mechanical stimulus; cellular response to progesterone stimulus; cellular response to testosterone stimulus; cellular response to transforming growth factor beta stimulus; cellular response to zinc ion starvation; cellular senescence; cerebellum development; dendritic spine maintenance; establishment of cell polarity; estrous cycle; glucose homeostasis; hippocampus development; immune response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of apoptotic process; negative regulation of cholangiocyte apoptotic process; negative regulation of hepatocyte apoptotic process; negative regulation of MAPK cascade; negative regulation of muscle cell apoptotic process; neuron projection development; peptidyl-tyrosine autophosphorylation; phosphatidylinositol 3-kinase signaling; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of axon regeneration; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cold-induced thermogenesis; positive regulation of cytokinesis; positive regulation of DNA metabolic process; positive regulation of kinase activity; positive regulation of MAPK cascade; positive regulation of osteoblast proliferation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of protein-containing complex disassembly; positive regulation of smooth muscle cell proliferation; positive regulation of steroid hormone biosynthetic process; protein autophosphorylation; protein phosphorylation; regulation of JNK cascade; response to ethanol; response to insulin; response to L-glutamate; response to nicotine; response to nutrient levels; response to vitamin E; signal transduction; transcytosis; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; G-protein alpha-subunit binding; identical protein binding; insulin binding; insulin receptor activity; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; protein binding; protein kinase activity; protein transporter activity; protein tyrosine kinase activity; protein-containing complex binding; transferase activity; transmembrane receptor protein tyrosine kinase activity","alphav-beta3 integrin-IGF-1-IGF1R complex; axon; caveola; cytoplasm; insulin receptor complex; intracellular membrane-bounded organelle; membrane; neuron projection; neuronal cell body; nucleus; plasma membrane; protein kinase complex; receptor complex; T-tubule","Insulin signaling","insulin like growth factor 1 receptor","http://www.ncbi.nlm.nih.gov/gene/?term=3480","3480","16001","25718",null,null,"708227","P08069","E9QNX9","P24062","A0A8I3MMA7",null,"I2CWY3","GO:0035867; GO:0030424; GO:0005901; GO:0005737; GO:0005899; GO:0043231; GO:0016020; GO:0043005; GO:0043025; GO:0005634; GO:0005886; GO:1902911; GO:0043235; GO:0030315","GO:0005524; GO:0001965; GO:0042802; GO:0043559; GO:0005009; GO:0005158; GO:0043560; GO:0005520; GO:0031994; GO:0005010; GO:0016301; GO:0000166; GO:0043548; GO:0005515; GO:0004672; GO:0140318; GO:0004713; GO:0044877; GO:0016740; GO:0004714","GO:0007568; GO:0097242; GO:0007409; GO:0003230; GO:1904045; GO:1904646; GO:1904385; GO:0071549; GO:0071392; GO:0071333; GO:0032869; GO:1990314; GO:0071260; GO:0071393; GO:0071394; GO:0071560; GO:0034224; GO:0090398; GO:0021549; GO:0097062; GO:0030010; GO:0044849; GO:0042593; GO:0021766; GO:0006955; GO:0008286; GO:0048009; GO:0043066; GO:1904193; GO:1903944; GO:0043409; GO:0010656; GO:0031175; GO:0038083; GO:0014065; GO:0048015; GO:0016310; GO:0048680; GO:0030335; GO:0008284; GO:0120162; GO:0032467; GO:0051054; GO:0033674; GO:0043410; GO:0033690; GO:0014068; GO:0051897; GO:0043243; GO:0048661; GO:0090031; GO:0046777; GO:0006468; GO:0046328; GO:0045471; GO:0032868; GO:1902065; GO:0035094; GO:0031667; GO:0033197; GO:0007165; GO:0045056; GO:0007169","PTHR24416:SF106","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5465|UniProtKB=P08069","P00032; P00033; P06664"]
["IGF-1R beta / IR beta",null,"IGF1R","95","rb",null,2,4,8,2,1,1,"# 0597",".AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DRR., .EGFR., .FOXO., .GLI., .HIF., .IMU., .IMUR., .INS., .JNK., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway","INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR","aging; amyloid-beta clearance; axonogenesis; cardiac atrium development; cellular response to aldosterone; cellular response to amyloid-beta; cellular response to angiotensin; cellular response to dexamethasone stimulus; cellular response to estradiol stimulus; cellular response to glucose stimulus; cellular response to insulin stimulus; cellular response to insulin-like growth factor stimulus; cellular response to mechanical stimulus; cellular response to progesterone stimulus; cellular response to testosterone stimulus; cellular response to transforming growth factor beta stimulus; cellular response to zinc ion starvation; cellular senescence; cerebellum development; dendritic spine maintenance; establishment of cell polarity; estrous cycle; glucose homeostasis; hippocampus development; immune response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of apoptotic process; negative regulation of cholangiocyte apoptotic process; negative regulation of hepatocyte apoptotic process; negative regulation of MAPK cascade; negative regulation of muscle cell apoptotic process; neuron projection development; peptidyl-tyrosine autophosphorylation; phosphatidylinositol 3-kinase signaling; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of axon regeneration; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cold-induced thermogenesis; positive regulation of cytokinesis; positive regulation of DNA metabolic process; positive regulation of kinase activity; positive regulation of MAPK cascade; positive regulation of osteoblast proliferation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of protein-containing complex disassembly; positive regulation of smooth muscle cell proliferation; positive regulation of steroid hormone biosynthetic process; protein autophosphorylation; protein phosphorylation; regulation of JNK cascade; response to ethanol; response to insulin; response to L-glutamate; response to nicotine; response to nutrient levels; response to vitamin E; signal transduction; transcytosis; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; G-protein alpha-subunit binding; identical protein binding; insulin binding; insulin receptor activity; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; protein binding; protein kinase activity; protein transporter activity; protein tyrosine kinase activity; protein-containing complex binding; transferase activity; transmembrane receptor protein tyrosine kinase activity","alphav-beta3 integrin-IGF-1-IGF1R complex; axon; caveola; cytoplasm; insulin receptor complex; intracellular membrane-bounded organelle; membrane; neuron projection; neuronal cell body; nucleus; plasma membrane; protein kinase complex; receptor complex; T-tubule","Insulin signaling","insulin like growth factor 1 receptor","http://www.ncbi.nlm.nih.gov/gene/?term=3480","3480","16001","25718",null,null,"708227","P08069","E9QNX9","P24062","A0A8I3MMA7",null,"I2CWY3","GO:0035867; GO:0030424; GO:0005901; GO:0005737; GO:0005899; GO:0043231; GO:0016020; GO:0043005; GO:0043025; GO:0005634; GO:0005886; GO:1902911; GO:0043235; GO:0030315","GO:0005524; GO:0001965; GO:0042802; GO:0043559; GO:0005009; GO:0005158; GO:0043560; GO:0005520; GO:0031994; GO:0005010; GO:0016301; GO:0000166; GO:0043548; GO:0005515; GO:0004672; GO:0140318; GO:0004713; GO:0044877; GO:0016740; GO:0004714","GO:0007568; GO:0097242; GO:0007409; GO:0003230; GO:1904045; GO:1904646; GO:1904385; GO:0071549; GO:0071392; GO:0071333; GO:0032869; GO:1990314; GO:0071260; GO:0071393; GO:0071394; GO:0071560; GO:0034224; GO:0090398; GO:0021549; GO:0097062; GO:0030010; GO:0044849; GO:0042593; GO:0021766; GO:0006955; GO:0008286; GO:0048009; GO:0043066; GO:1904193; GO:1903944; GO:0043409; GO:0010656; GO:0031175; GO:0038083; GO:0014065; GO:0048015; GO:0016310; GO:0048680; GO:0030335; GO:0008284; GO:0120162; GO:0032467; GO:0051054; GO:0033674; GO:0043410; GO:0033690; GO:0014068; GO:0051897; GO:0043243; GO:0048661; GO:0090031; GO:0046777; GO:0006468; GO:0046328; GO:0045471; GO:0032868; GO:1902065; GO:0035094; GO:0031667; GO:0033197; GO:0007165; GO:0045056; GO:0007169","PTHR24416:SF106","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5465|UniProtKB=P08069","P00032; P00033; P06664"]
["IGF-1R beta / IR beta - phospho","Tyr1135/Tyr1136resp.Tyr1150/Tyr1151","IGF1R, INSR","95","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1491",".ALZ., .AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D300., .DI., .DMTOR., .DRR., .EGFR., .FOXO., .GLI., .GPCR., .GPROT., .HIF., .IMU., .IMUR., .INS., .JNK., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TRASR., .VIR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; PI3 kinase pathway","INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR; INSULIN RECEPTOR","aging; amyloid-beta clearance; axonogenesis; cardiac atrium development; cellular response to aldosterone; cellular response to amyloid-beta; cellular response to angiotensin; cellular response to dexamethasone stimulus; cellular response to estradiol stimulus; cellular response to glucose stimulus; cellular response to insulin stimulus; cellular response to insulin-like growth factor stimulus; cellular response to mechanical stimulus; cellular response to progesterone stimulus; cellular response to testosterone stimulus; cellular response to transforming growth factor beta stimulus; cellular response to zinc ion starvation; cellular senescence; cerebellum development; dendritic spine maintenance; establishment of cell polarity; estrous cycle; glucose homeostasis; hippocampus development; immune response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of apoptotic process; negative regulation of cholangiocyte apoptotic process; negative regulation of hepatocyte apoptotic process; negative regulation of MAPK cascade; negative regulation of muscle cell apoptotic process; neuron projection development; peptidyl-tyrosine autophosphorylation; phosphatidylinositol 3-kinase signaling; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of axon regeneration; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cold-induced thermogenesis; positive regulation of cytokinesis; positive regulation of DNA metabolic process; positive regulation of kinase activity; positive regulation of MAPK cascade; positive regulation of osteoblast proliferation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of protein-containing complex disassembly; positive regulation of smooth muscle cell proliferation; positive regulation of steroid hormone biosynthetic process; protein autophosphorylation; protein phosphorylation; regulation of JNK cascade; response to ethanol; response to insulin; response to L-glutamate; response to nicotine; response to nutrient levels; response to vitamin E; signal transduction; transcytosis; transmembrane receptor protein tyrosine kinase signaling pathway; activation of protein kinase activity; activation of protein kinase B activity; adrenal gland development; animal organ morphogenesis; carbohydrate metabolic process; cellular response to growth factor stimulus; epidermis development; exocrine pancreas development; G protein-coupled receptor signaling pathway; heart morphogenesis; learning; male gonad development; male sex determination; memory; neuron projection maintenance; peptidyl-tyrosine phosphorylation; positive regulation of developmental growth; positive regulation of DNA-templated transcription; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of glycolytic process; positive regulation of MAP kinase activity; positive regulation of meiotic cell cycle; positive regulation of mitotic nuclear division; positive regulation of nitric oxide biosynthetic process; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of respiratory burst; receptor internalization; receptor-mediated endocytosis; regulation of DNA-templated transcription; regulation of embryonic development; regulation of female gonad development; transport across blood-brain barrier; viral entry into host cell","ATP binding; G-protein alpha-subunit binding; identical protein binding; insulin binding; insulin receptor activity; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; protein binding; protein kinase activity; protein transporter activity; protein tyrosine kinase activity; protein-containing complex binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; 1-phosphatidylinositol-3-kinase regulator activity; amyloid-beta binding; cargo receptor activity; GTP binding; insulin-like growth factor II binding; insulin-like growth factor receptor binding; molecular function activator activity; protein domain specific binding; protein serine/threonine kinase activator activity; protein tyrosine kinase activator activity; PTB domain binding","alphav-beta3 integrin-IGF-1-IGF1R complex; axon; caveola; cytoplasm; insulin receptor complex; intracellular membrane-bounded organelle; membrane; neuron projection; neuronal cell body; nucleus; plasma membrane; protein kinase complex; receptor complex; T-tubule; dendrite membrane; endosome; endosome membrane; external side of plasma membrane; extracellular exosome; late endosome; lysosome; neuronal cell body membrane; nuclear envelope; nuclear lumen","Insulin signaling","insulin like growth factor 1 receptor; insulin receptor","http://www.ncbi.nlm.nih.gov/gene/?term=3480, http://www.ncbi.nlm.nih.gov/gene/?term=3643","3480, 3643","16001, 16337","25718, NA",null,"","708227, NA","P08069, P06213","E9QNX9, P15208","P24062, A0A8I5ZMZ8","A0A8I3MMA7, A0A8I3PNN8","F1SCK8","I2CWY3, A0A1D5QCC6","GO:0035867; GO:0030424; GO:0005901; GO:0005737; GO:0005899; GO:0043231; GO:0016020; GO:0043005; GO:0043025; GO:0005634; GO:0005886; GO:1902911; GO:0043235; GO:0030315; GO:0032590; GO:0005768; GO:0010008; GO:0009897; GO:0070062; GO:0005770; GO:0005764; GO:0032809; GO:0005635; GO:0031981","GO:0005524; GO:0001965; GO:0042802; GO:0043559; GO:0005009; GO:0005158; GO:0043560; GO:0005520; GO:0031994; GO:0005010; GO:0016301; GO:0000166; GO:0043548; GO:0005515; GO:0004672; GO:0140318; GO:0004713; GO:0044877; GO:0016740; GO:0004714; GO:0046935; GO:0001540; GO:0038024; GO:0005525; GO:0031995; GO:0005159; GO:0140677; GO:0019904; GO:0043539; GO:0030296; GO:0051425","GO:0007568; GO:0097242; GO:0007409; GO:0003230; GO:1904045; GO:1904646; GO:1904385; GO:0071549; GO:0071392; GO:0071333; GO:0032869; GO:1990314; GO:0071260; GO:0071393; GO:0071394; GO:0071560; GO:0034224; GO:0090398; GO:0021549; GO:0097062; GO:0030010; GO:0044849; GO:0042593; GO:0021766; GO:0006955; GO:0008286; GO:0048009; GO:0043066; GO:1904193; GO:1903944; GO:0043409; GO:0010656; GO:0031175; GO:0038083; GO:0014065; GO:0048015; GO:0016310; GO:0048680; GO:0030335; GO:0008284; GO:0120162; GO:0032467; GO:0051054; GO:0033674; GO:0043410; GO:0033690; GO:0014068; GO:0051897; GO:0043243; GO:0048661; GO:0090031; GO:0046777; GO:0006468; GO:0046328; GO:0045471; GO:0032868; GO:1902065; GO:0035094; GO:0031667; GO:0033197; GO:0007165; GO:0045056; GO:0007169; GO:0032147; GO:0032148; GO:0030325; GO:0009887; GO:0005975; GO:0071363; GO:0008544; GO:0031017; GO:0007186; GO:0003007; GO:0007612; GO:0008584; GO:0030238; GO:0007613; GO:1990535; GO:0018108; GO:0048639; GO:0045893; GO:0046326; GO:0045725; GO:0045821; GO:0043406; GO:0051446; GO:0045840; GO:0045429; GO:0001934; GO:0002092; GO:0060267; GO:0031623; GO:0006898; GO:0006355; GO:0045995; GO:2000194; GO:0150104; GO:0046718","PTHR24416:SF106; PTHR24416:SF535","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5465|UniProtKB=P08069; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6091|UniProtKB=P06213","P00032; P00033; P06664; P00048"]
["IGFBP-1",null,"IGFBP1","36","gt",null,2,6,2,6,6,6,"# 1084",".CCP., .CP., .CSP., .DEV., .INS., .OP., .OPA., .PI3K., .RTK., .SREME., .ST., .WNT.","PI3 kinase pathway","INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1","aging; insulin receptor signaling pathway; multicellular organism aging; negative regulation of canonical Wnt signaling pathway; positive regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; response to organic cyclic compound; signal transduction; tissue regeneration","growth factor binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding; signaling receptor binding","endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus","Insulin signaling","insulin like growth factor binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=3484","3484","16006","25685",null,"397270",null,"P08833","P47876","P21743",null,"E0A8P1",null,"GO:0005788; GO:0005576; GO:0005615; GO:0005794","GO:0019838; GO:0005520; GO:0031994; GO:0031995; GO:0005515; GO:0005102","GO:0007568; GO:0008286; GO:0010259; GO:0090090; GO:0030307; GO:0043567; GO:0014070; GO:0007165; GO:0042246","PTHR11551:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5469|UniProtKB=P08833","P00048"]
["IGFBP-1",null,"IGFBP1","36","rb",null,6,6,2,2,2,2,"# 1158",".CCP., .CP., .CSP., .DEV., .INS., .OP., .OPA., .PI3K., .RTK., .SREME., .ST., .WNT.","PI3 kinase pathway","INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1","aging; insulin receptor signaling pathway; multicellular organism aging; negative regulation of canonical Wnt signaling pathway; positive regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; response to organic cyclic compound; signal transduction; tissue regeneration","growth factor binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding; signaling receptor binding","endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus","Insulin signaling","insulin like growth factor binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=3484","3484","16006","25685",null,"397270",null,"P08833","P47876","P21743",null,"E0A8P1",null,"GO:0005788; GO:0005576; GO:0005615; GO:0005794","GO:0019838; GO:0005520; GO:0031994; GO:0031995; GO:0005515; GO:0005102","GO:0007568; GO:0008286; GO:0010259; GO:0090090; GO:0030307; GO:0043567; GO:0014070; GO:0007165; GO:0042246","PTHR11551:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5469|UniProtKB=P08833","P00048"]
["IGFBP-2",null,"IGFBP2","35","rb",null,2,7,8,8,8,2,"# 0585",".CSP., .DEV., .DRR., .IMUF., .INS., .OP., .OPA., .OT., .SREME., .ST., .TCR., .WNT.",null,"INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2","aging; cellular response to hormone stimulus; female pregnancy; negative regulation of canonical Wnt signaling pathway; positive regulation of activated T cell proliferation; regulation of insulin-like growth factor receptor signaling pathway; response to estradiol; response to estrogen; response to glucocorticoid; response to lithium ion; response to mechanical stimulus; response to nutrient; response to organic cyclic compound; response to retinoic acid; response to steroid hormone; response to xenobiotic stimulus; signal transduction","growth factor binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding; signaling receptor binding","apical plasma membrane; cytoplasmic vesicle; extracellular exosome; extracellular region; extracellular space","Insulin signaling","insulin like growth factor binding protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=3485","3485","16008","25662",null,null,null,"P18065","P47877","P12843","A0A8P0SJB9",null,null,"GO:0016324; GO:0031410; GO:0070062; GO:0005576; GO:0005615","GO:0019838; GO:0005520; GO:0031994; GO:0031995; GO:0005515; GO:0005102","GO:0007568; GO:0032870; GO:0007565; GO:0090090; GO:0042104; GO:0043567; GO:0032355; GO:0043627; GO:0051384; GO:0010226; GO:0009612; GO:0007584; GO:0014070; GO:0032526; GO:0048545; GO:0009410; GO:0007165","PTHR11551:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5471|UniProtKB=P18065"]
["IGFBP-3",null,"IGFBP3","32","rb",null,2,4,7,7,1,1,"# 1416",".APO., .CCP., .CD., .CP., .CSP., .INS., .MAPK., .MIG., .OP., .OPA., .OT., .P53S., .RTK., .SREME., .ST.","p53 pathway","INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3","apoptotic process; MAPK cascade; negative regulation of cell population proliferation; negative regulation of protein phosphorylation; negative regulation of signal transduction; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; osteoblast differentiation; positive regulation of apoptotic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; protein phosphorylation; regulation of cell growth; regulation of glucose metabolic process; regulation of growth; regulation of insulin-like growth factor receptor signaling pathway; type B pancreatic cell proliferation","fibronectin binding; growth factor binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; metal ion binding; protein binding; protein tyrosine phosphatase activator activity","endoplasmic reticulum lumen; extracellular region; extracellular space; insulin-like growth factor binding protein complex; insulin-like growth factor ternary complex; nucleus","Insulin signaling","insulin like growth factor binding protein 3","http://www.ncbi.nlm.nih.gov/gene/?term=3486","3486","16009","24484",null,null,"696868","P17936","P47878","A0A0G2K4Q9","A0A8I3N8K1",null,"I0FH47","GO:0005788; GO:0005576; GO:0005615; GO:0016942; GO:0042567; GO:0005634","GO:0001968; GO:0019838; GO:0005520; GO:0031994; GO:0031995; GO:0046872; GO:0005515; GO:0008160","GO:0006915; GO:0000165; GO:0008285; GO:0001933; GO:0009968; GO:0014912; GO:0048662; GO:0001649; GO:0043065; GO:0043568; GO:0043410; GO:0045663; GO:0006468; GO:0001558; GO:0010906; GO:0040008; GO:0043567; GO:0044342","PTHR11551:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5472|UniProtKB=P17936","P00059"]
["IGFBP-5",null,"IGFBP5","30","rb",null,7,1,"n/a","n/a","n/a","n/a","# 0586",".cAMP., .CCP., .CP., .CSP., .GPCR., .INS., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TRASR.",null,"INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 5","aging; cellular response to cAMP; cellular response to organic cyclic compound; female pregnancy; glucose homeostasis; hair follicle morphogenesis; insulin-like growth factor receptor signaling pathway; intracellular signal transduction; lung alveolus development; mammary gland involution; negative regulation of cell migration; negative regulation of growth; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of muscle tissue development; negative regulation of osteoblast differentiation; negative regulation of skeletal muscle hypertrophy; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; negative regulation of translation; osteoblast differentiation; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; regulation of cell growth; regulation of growth; regulation of insulin-like growth factor receptor signaling pathway; response to growth hormone; response to organic cyclic compound; response to stimulus; signal transduction; striated muscle cell differentiation; type B pancreatic cell proliferation","fibronectin binding; growth factor binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding","endoplasmic reticulum lumen; extracellular region; extracellular space; insulin-like growth factor binding protein complex; insulin-like growth factor ternary complex","Insulin signaling","insulin like growth factor binding protein 5","http://www.ncbi.nlm.nih.gov/gene/?term=3488","3488","16011","25285",null,"100738836","696339","P24593","Q07079","P24594",null,"E2I6L6","F6YKJ0","GO:0005788; GO:0005576; GO:0005615; GO:0016942; GO:0042567","GO:0001968; GO:0019838; GO:0005520; GO:0031994; GO:0031995; GO:0005515","GO:0007568; GO:0071320; GO:0071407; GO:0007565; GO:0042593; GO:0031069; GO:0048009; GO:0035556; GO:0048286; GO:0060056; GO:0030336; GO:0045926; GO:0043569; GO:1901862; GO:0045668; GO:1904205; GO:0014912; GO:0048662; GO:0017148; GO:0001649; GO:0043568; GO:0051897; GO:1904754; GO:1904707; GO:0001558; GO:0040008; GO:0043567; GO:0060416; GO:0014070; GO:0050896; GO:0007165; GO:0051146; GO:0044342","PTHR11551:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5474|UniProtKB=P24593"]
["IGFBP-5",null,"IGFBP5","31","rb",null,2,1,"n/a","n/a","n/a","n/a","# 2298",".cAMP., .CCP., .CP., .CSP., .GPCR., .INS., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TRASR.",null,"INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 5","aging; cellular response to cAMP; cellular response to organic cyclic compound; female pregnancy; glucose homeostasis; hair follicle morphogenesis; insulin-like growth factor receptor signaling pathway; intracellular signal transduction; lung alveolus development; mammary gland involution; negative regulation of cell migration; negative regulation of growth; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of muscle tissue development; negative regulation of osteoblast differentiation; negative regulation of skeletal muscle hypertrophy; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; negative regulation of translation; osteoblast differentiation; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; regulation of cell growth; regulation of growth; regulation of insulin-like growth factor receptor signaling pathway; response to growth hormone; response to organic cyclic compound; response to stimulus; signal transduction; striated muscle cell differentiation; type B pancreatic cell proliferation","fibronectin binding; growth factor binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding","endoplasmic reticulum lumen; extracellular region; extracellular space; insulin-like growth factor binding protein complex; insulin-like growth factor ternary complex","Insulin signaling","insulin like growth factor binding protein 5","http://www.ncbi.nlm.nih.gov/gene/?term=3488","3488","16011","25285",null,"100738836","696339","P24593","Q07079","P24594",null,"E2I6L6","F6YKJ0","GO:0005788; GO:0005576; GO:0005615; GO:0016942; GO:0042567","GO:0001968; GO:0019838; GO:0005520; GO:0031994; GO:0031995; GO:0005515","GO:0007568; GO:0071320; GO:0071407; GO:0007565; GO:0042593; GO:0031069; GO:0048009; GO:0035556; GO:0048286; GO:0060056; GO:0030336; GO:0045926; GO:0043569; GO:1901862; GO:0045668; GO:1904205; GO:0014912; GO:0048662; GO:0017148; GO:0001649; GO:0043568; GO:0051897; GO:1904754; GO:1904707; GO:0001558; GO:0040008; GO:0043567; GO:0060416; GO:0014070; GO:0050896; GO:0007165; GO:0051146; GO:0044342","PTHR11551:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5474|UniProtKB=P24593"]
["Ihh",null,"IHH","45","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1670",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .HHSP., .IMUF., .OP., .OPA., .OT., .ST., .TCD., .TCR., .TMAT., .TRASR.",null,"INDIAN HEDGEHOG PROTEIN","animal organ development; bone resorption; branching involved in blood vessel morphogenesis; camera-type eye development; camera-type eye photoreceptor cell fate commitment; cartilage development; cell fate specification; cell maturation; cell population proliferation; cell-cell signaling; chondrocyte differentiation; chondrocyte differentiation involved in endochondral bone morphogenesis; chondrocyte proliferation; embryonic camera-type eye morphogenesis; embryonic digestive tract morphogenesis; embryonic digit morphogenesis; embryonic pattern specification; embryonic skeletal joint development; epithelial cell morphogenesis; epithelial cell-cell adhesion; head morphogenesis; heart looping; in utero embryonic development; intein-mediated protein splicing; liver regeneration; maternal process involved in female pregnancy; morphogenesis of a branching structure; multicellular organism growth; negative regulation of alpha-beta T cell differentiation; negative regulation of apoptotic process; negative regulation of chondrocyte differentiation; negative regulation of eye pigmentation; negative regulation of immature T cell proliferation in thymus; negative regulation of T cell differentiation in thymus; neuron development; ossification; osteoblast differentiation; pancreas development; pattern specification process; positive regulation of alpha-beta T cell differentiation; positive regulation of cell population proliferation; positive regulation of collagen biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; positive regulation of T cell differentiation in thymus; positive regulation of transcription by RNA polymerase II; protein autoprocessing; proteoglycan metabolic process; proteolysis; regulation of gene expression; regulation of growth; response to estradiol; response to mechanical stimulus; retinal pigment epithelium development; self proteolysis; skeletal system development; smooth muscle tissue development; smoothened signaling pathway; somite development; system development; vasculature development; vitelline membrane formation","calcium ion binding; cholesterol-protein transferase activity; hydrolase activity; metal ion binding; patched binding; peptidase activity; protein binding; transferase activity","endoplasmic reticulum; endoplasmic reticulum membrane; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; membrane; plasma membrane",null,"Indian hedgehog signaling molecule","http://www.ncbi.nlm.nih.gov/gene/?term=3549","3549","16147","84399",null,null,"704046","Q14623","P97812","F1LP42",null,"F1SRW6","F6RAT8","GO:0005783; GO:0005789; GO:0031012; GO:0005576; GO:0005615; GO:0005794; GO:0000139; GO:0016020; GO:0005886","GO:0005509; GO:0140853; GO:0016787; GO:0046872; GO:0005113; GO:0008233; GO:0005515; GO:0016740","GO:0048513; GO:0045453; GO:0001569; GO:0043010; GO:0060220; GO:0051216; GO:0001708; GO:0048469; GO:0008283; GO:0007267; GO:0002062; GO:0003413; GO:0035988; GO:0048596; GO:0048557; GO:0042733; GO:0009880; GO:0072498; GO:0003382; GO:0090136; GO:0060323; GO:0001947; GO:0001701; GO:0016539; GO:0097421; GO:0060135; GO:0001763; GO:0035264; GO:0046639; GO:0043066; GO:0032331; GO:0048074; GO:0033088; GO:0033085; GO:0048666; GO:0001503; GO:0001649; GO:0031016; GO:0007389; GO:0046638; GO:0008284; GO:0032967; GO:0050679; GO:0002053; GO:0045880; GO:0033089; GO:0045944; GO:0016540; GO:0006029; GO:0006508; GO:0010468; GO:0040008; GO:0032355; GO:0009612; GO:0003406; GO:0097264; GO:0001501; GO:0048745; GO:0007224; GO:0061053; GO:0048731; GO:0001944; GO:0030704","PTHR11889:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5956|UniProtKB=Q14623"]
["IkappaB alpha",null,"NFKBIA","41","rb",null,2,1.1000000000000001,4,4,4,4,"# 0354",".APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CSP., .DEV., .DI., .DRR., .GPCR., .HEPB., .IMFR., .IMUF., .IMUR., .INFM., .INS., .NFKB., .NOTCH., .OP., .OPA., .OT., .PRC., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR.","CCKR signaling map; T cell activation; B cell activation; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","NF-KAPPA-B INHIBITOR ALPHA","apoptotic process; B cell receptor signaling pathway; cellular response to cold; cellular response to tumor necrosis factor; cytoplasmic sequestering of NF-kappaB; cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB signaling; lipopolysaccharide-mediated signaling pathway; negative regulation of DNA binding; negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; negative regulation of myeloid cell differentiation; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; Notch signaling pathway; nucleotide-binding oligomerization domain containing 1 signaling pathway; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of cholesterol efflux; positive regulation of DNA-templated transcription; positive regulation of inflammatory response; positive regulation of protein metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein import into nucleus; regulation of cell population proliferation; regulation of gene expression; regulation of NIK/NF-kappaB signaling; response to exogenous dsRNA; response to lipopolysaccharide; response to muramyl dipeptide; response to muscle stretch; toll-like receptor 4 signaling pathway; tumor necrosis factor-mediated signaling pathway","enzyme binding; identical protein binding; NF-kappaB binding; nuclear localization sequence binding; protein binding; ubiquitin protein ligase binding","cytoplasm; cytosol; I-kappaB/NF-kappaB complex; nucleoplasm; nucleus; plasma membrane","NFkB signaling","NFKB inhibitor alpha","http://www.ncbi.nlm.nih.gov/gene/?term=4792","4792","18035","25493","480291","406188","695335","P25963","Q9Z1E3","Q63746","A0A8I3MKL4","Q08353","H9FUW3","GO:0005737; GO:0005829; GO:0033256; GO:0005654; GO:0005634; GO:0005886","GO:0019899; GO:0042802; GO:0051059; GO:0008139; GO:0005515; GO:0031625","GO:0006915; GO:0050853; GO:0070417; GO:0071356; GO:0007253; GO:0042994; GO:0007249; GO:0031663; GO:0043392; GO:0010888; GO:0010745; GO:0045638; GO:0032088; GO:0045746; GO:0007219; GO:0070427; GO:0070431; GO:0010875; GO:0045893; GO:0050729; GO:0051247; GO:0045944; GO:0060261; GO:0006606; GO:0042127; GO:0010468; GO:1901222; GO:0043330; GO:0032496; GO:0032495; GO:0035994; GO:0034142; GO:0033209","PTHR46680:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7797|UniProtKB=P25963","P06959; P00053; P00010; P00054; P00031; P00006"]
["IkappaB alpha - phospho","Ser32","NFKBIA","41","rb",null,2,1.1000000000000001,4,4,4,4,"# 0309",".APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CSP., .DEV., .DI., .DRR., .GPCR., .HEPB., .IMFR., .IMUF., .IMUR., .INFM., .INS., .NFKB., .NOTCH., .OP., .OPA., .OT., .PRC., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR.","CCKR signaling map; T cell activation; B cell activation; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","NF-KAPPA-B INHIBITOR ALPHA","apoptotic process; B cell receptor signaling pathway; cellular response to cold; cellular response to tumor necrosis factor; cytoplasmic sequestering of NF-kappaB; cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB signaling; lipopolysaccharide-mediated signaling pathway; negative regulation of DNA binding; negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; negative regulation of myeloid cell differentiation; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; Notch signaling pathway; nucleotide-binding oligomerization domain containing 1 signaling pathway; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of cholesterol efflux; positive regulation of DNA-templated transcription; positive regulation of inflammatory response; positive regulation of protein metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein import into nucleus; regulation of cell population proliferation; regulation of gene expression; regulation of NIK/NF-kappaB signaling; response to exogenous dsRNA; response to lipopolysaccharide; response to muramyl dipeptide; response to muscle stretch; toll-like receptor 4 signaling pathway; tumor necrosis factor-mediated signaling pathway","enzyme binding; identical protein binding; NF-kappaB binding; nuclear localization sequence binding; protein binding; ubiquitin protein ligase binding","cytoplasm; cytosol; I-kappaB/NF-kappaB complex; nucleoplasm; nucleus; plasma membrane","NFkB signaling","NFKB inhibitor alpha","http://www.ncbi.nlm.nih.gov/gene/?term=4792","4792","18035","25493","480291","406188","695335","P25963","Q9Z1E3","Q63746","A0A8I3MKL4","Q08353","H9FUW3","GO:0005737; GO:0005829; GO:0033256; GO:0005654; GO:0005634; GO:0005886","GO:0019899; GO:0042802; GO:0051059; GO:0008139; GO:0005515; GO:0031625","GO:0006915; GO:0050853; GO:0070417; GO:0071356; GO:0007253; GO:0042994; GO:0007249; GO:0031663; GO:0043392; GO:0010888; GO:0010745; GO:0045638; GO:0032088; GO:0045746; GO:0007219; GO:0070427; GO:0070431; GO:0010875; GO:0045893; GO:0050729; GO:0051247; GO:0045944; GO:0060261; GO:0006606; GO:0042127; GO:0010468; GO:1901222; GO:0043330; GO:0032496; GO:0032495; GO:0035994; GO:0034142; GO:0033209","PTHR46680:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7797|UniProtKB=P25963","P06959; P00053; P00010; P00054; P00031; P00006"]
["IkappaB alpha - phospho","Ser32","NFKBIA","40","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1832",".APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CSP., .DEV., .DI., .DRR., .GPCR., .HEPB., .IMFR., .IMUF., .IMUR., .INFM., .INS., .NFKB., .NOTCH., .OP., .OPA., .OT., .PRC., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR.","CCKR signaling map; T cell activation; B cell activation; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","NF-KAPPA-B INHIBITOR ALPHA","apoptotic process; B cell receptor signaling pathway; cellular response to cold; cellular response to tumor necrosis factor; cytoplasmic sequestering of NF-kappaB; cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB signaling; lipopolysaccharide-mediated signaling pathway; negative regulation of DNA binding; negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; negative regulation of myeloid cell differentiation; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; Notch signaling pathway; nucleotide-binding oligomerization domain containing 1 signaling pathway; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of cholesterol efflux; positive regulation of DNA-templated transcription; positive regulation of inflammatory response; positive regulation of protein metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein import into nucleus; regulation of cell population proliferation; regulation of gene expression; regulation of NIK/NF-kappaB signaling; response to exogenous dsRNA; response to lipopolysaccharide; response to muramyl dipeptide; response to muscle stretch; toll-like receptor 4 signaling pathway; tumor necrosis factor-mediated signaling pathway","enzyme binding; identical protein binding; NF-kappaB binding; nuclear localization sequence binding; protein binding; ubiquitin protein ligase binding","cytoplasm; cytosol; I-kappaB/NF-kappaB complex; nucleoplasm; nucleus; plasma membrane","NFkB signaling","NFKB inhibitor alpha","http://www.ncbi.nlm.nih.gov/gene/?term=4792","4792","18035","25493","480291","406188","695335","P25963","Q9Z1E3","Q63746","A0A8I3MKL4","Q08353","H9FUW3","GO:0005737; GO:0005829; GO:0033256; GO:0005654; GO:0005634; GO:0005886","GO:0019899; GO:0042802; GO:0051059; GO:0008139; GO:0005515; GO:0031625","GO:0006915; GO:0050853; GO:0070417; GO:0071356; GO:0007253; GO:0042994; GO:0007249; GO:0031663; GO:0043392; GO:0010888; GO:0010745; GO:0045638; GO:0032088; GO:0045746; GO:0007219; GO:0070427; GO:0070431; GO:0010875; GO:0045893; GO:0050729; GO:0051247; GO:0045944; GO:0060261; GO:0006606; GO:0042127; GO:0010468; GO:1901222; GO:0043330; GO:0032496; GO:0032495; GO:0035994; GO:0034142; GO:0033209","PTHR46680:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7797|UniProtKB=P25963","P06959; P00053; P00010; P00054; P00031; P00006"]
["IKK alpha",null,"CHUK","85","rb",null,2,2,1,1.1000000000000001,1,1,"# 2472",".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","T cell activation; B cell activation; Interleukin signaling pathway; PDGF signaling pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA","anatomical structure morphogenesis; cellular response to cadmium ion; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to virus; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; immune response; inflammatory response; innate immune response; negative regulation of NF-kappaB transcription factor activity; NIK/NF-kappaB signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha production; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; protein phosphorylation; response to stimulus; response to virus; tumor necrosis factor-mediated signaling pathway","ATP binding; IkappaB kinase activity; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; scaffold protein binding; transferase activity; transferrin receptor binding","CD40 receptor complex; cytoplasm; cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; nucleoplasm; nucleus","NFkB signaling","component of inhibitor of nuclear factor kappa B kinase complex","http://www.ncbi.nlm.nih.gov/gene/?term=1147","1147","12675",null,"477796",null,"709511","O15111","E9Q605","A0A8I5ZSH4","A0A8I3P499","F1S8V5","A0A1D5Q734","GO:0035631; GO:0005737; GO:0009898; GO:0005829; GO:0008385; GO:0005654; GO:0005634","GO:0005524; GO:0008384; GO:0016301; GO:0000166; GO:0005515; GO:0046982; GO:0042803; GO:0004672; GO:0004674; GO:0097110; GO:0016740; GO:1990459","GO:0009653; GO:0071276; GO:0034614; GO:0071356; GO:0098586; GO:0007249; GO:0007252; GO:0006955; GO:0006954; GO:0045087; GO:0032088; GO:0038061; GO:0018105; GO:0016310; GO:0045893; GO:0043123; GO:0032727; GO:0051092; GO:0045944; GO:0006468; GO:0050896; GO:0009615; GO:0033209","PTHR22969:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1974|UniProtKB=O15111","P00053; P00010; P00036; P00047; P00054; P00031; P00006"]
["IKK alpha - phospho","Thr23","CHUK","85","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2339",".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","T cell activation; B cell activation; Interleukin signaling pathway; PDGF signaling pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA","anatomical structure morphogenesis; cellular response to cadmium ion; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to virus; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; immune response; inflammatory response; innate immune response; negative regulation of NF-kappaB transcription factor activity; NIK/NF-kappaB signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha production; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; protein phosphorylation; response to stimulus; response to virus; tumor necrosis factor-mediated signaling pathway","ATP binding; IkappaB kinase activity; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; scaffold protein binding; transferase activity; transferrin receptor binding","CD40 receptor complex; cytoplasm; cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; nucleoplasm; nucleus",null,"component of inhibitor of nuclear factor kappa B kinase complex","http://www.ncbi.nlm.nih.gov/gene/?term=1147","1147","12675",null,"477796",null,"709511","O15111","E9Q605","A0A8I5ZSH4","A0A8I3P499","F1S8V5","A0A1D5Q734","GO:0035631; GO:0005737; GO:0009898; GO:0005829; GO:0008385; GO:0005654; GO:0005634","GO:0005524; GO:0008384; GO:0016301; GO:0000166; GO:0005515; GO:0046982; GO:0042803; GO:0004672; GO:0004674; GO:0097110; GO:0016740; GO:1990459","GO:0009653; GO:0071276; GO:0034614; GO:0071356; GO:0098586; GO:0007249; GO:0007252; GO:0006955; GO:0006954; GO:0045087; GO:0032088; GO:0038061; GO:0018105; GO:0016310; GO:0045893; GO:0043123; GO:0032727; GO:0051092; GO:0045944; GO:0006468; GO:0050896; GO:0009615; GO:0033209","PTHR22969:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1974|UniProtKB=O15111","P00053; P00010; P00036; P00047; P00054; P00031; P00006"]
["IKK alpha/beta - phospho","Ser176/177","CHUK, IKBKB","87, 85","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2368",".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","T cell activation; B cell activation; Interleukin signaling pathway; PDGF signaling pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA","anatomical structure morphogenesis; cellular response to cadmium ion; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to virus; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; immune response; inflammatory response; innate immune response; negative regulation of NF-kappaB transcription factor activity; NIK/NF-kappaB signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha production; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; protein phosphorylation; response to stimulus; response to virus; tumor necrosis factor-mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cortical actin cytoskeleton organization; Fc-epsilon receptor signaling pathway; interleukin-1-mediated signaling pathway; negative regulation of bicellular tight junction assembly; negative regulation of myosin-light-chain-phosphatase activity; protein localization to plasma membrane; regulation of establishment of endothelial barrier; regulation of phosphorylation; regulation of protein modification process; regulation of tumor necrosis factor-mediated signaling pathway; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway","ATP binding; IkappaB kinase activity; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; scaffold protein binding; transferase activity; transferrin receptor binding; identical protein binding; protein kinase binding; protein serine kinase activity","CD40 receptor complex; cytoplasm; cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; nucleoplasm; nucleus; membrane; membrane raft",null,"component of inhibitor of nuclear factor kappa B kinase complex; inhibitor of nuclear factor kappa B kinase subunit beta","http://www.ncbi.nlm.nih.gov/gene/?term=1147, http://www.ncbi.nlm.nih.gov/gene/?term=3551","1147, 3551","12675, 16150",null,"477796, NA",null,"709511, NA","O15111, O14920","E9Q605, A0A0R4J0T4","A0A8I5ZSH4, A0A8I5ZJG2","A0A8I3P499, A0A8I3MZ82","F1S8V5, A0A287A5Q1","A0A1D5Q734, F6SHB2","GO:0035631; GO:0005737; GO:0009898; GO:0005829; GO:0008385; GO:0005654; GO:0005634; GO:0016020; GO:0045121","GO:0005524; GO:0008384; GO:0016301; GO:0000166; GO:0005515; GO:0046982; GO:0042803; GO:0004672; GO:0004674; GO:0097110; GO:0016740; GO:1990459; GO:0042802; GO:0019901; GO:0106310","GO:0009653; GO:0071276; GO:0034614; GO:0071356; GO:0098586; GO:0007249; GO:0007252; GO:0006955; GO:0006954; GO:0045087; GO:0032088; GO:0038061; GO:0018105; GO:0016310; GO:0045893; GO:0043123; GO:0032727; GO:0051092; GO:0045944; GO:0006468; GO:0050896; GO:0009615; GO:0033209; GO:0002479; GO:0030866; GO:0038095; GO:0070498; GO:1903347; GO:0035509; GO:0072659; GO:1903140; GO:0042325; GO:0031399; GO:0010803; GO:0002223; GO:0051403; GO:0050852","PTHR22969:SF13; PTHR22969:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1974|UniProtKB=O15111; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5960|UniProtKB=O14920","P00053; P00010; P00036; P00047; P00054; P00031; P00006"]
["IKK alpha/beta - phospho","Ser176/Ser180","CHUK, IKBKB","87, 85","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1267",".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","T cell activation; B cell activation; Interleukin signaling pathway; PDGF signaling pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA","anatomical structure morphogenesis; cellular response to cadmium ion; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to virus; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; immune response; inflammatory response; innate immune response; negative regulation of NF-kappaB transcription factor activity; NIK/NF-kappaB signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha production; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; protein phosphorylation; response to stimulus; response to virus; tumor necrosis factor-mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cortical actin cytoskeleton organization; Fc-epsilon receptor signaling pathway; interleukin-1-mediated signaling pathway; negative regulation of bicellular tight junction assembly; negative regulation of myosin-light-chain-phosphatase activity; protein localization to plasma membrane; regulation of establishment of endothelial barrier; regulation of phosphorylation; regulation of protein modification process; regulation of tumor necrosis factor-mediated signaling pathway; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway","ATP binding; IkappaB kinase activity; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; scaffold protein binding; transferase activity; transferrin receptor binding; identical protein binding; protein kinase binding; protein serine kinase activity","CD40 receptor complex; cytoplasm; cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; nucleoplasm; nucleus; membrane; membrane raft",null,"component of inhibitor of nuclear factor kappa B kinase complex; inhibitor of nuclear factor kappa B kinase subunit beta","http://www.ncbi.nlm.nih.gov/gene/?term=1147, http://www.ncbi.nlm.nih.gov/gene/?term=3551","1147, 3551","12675, 16150",null,"477796, NA",null,"709511, NA","O15111, O14920","E9Q605, A0A0R4J0T4","A0A8I5ZSH4, A0A8I5ZJG2","A0A8I3P499, A0A8I3MZ82","F1S8V5, A0A287A5Q1","A0A1D5Q734, F6SHB2","GO:0035631; GO:0005737; GO:0009898; GO:0005829; GO:0008385; GO:0005654; GO:0005634; GO:0016020; GO:0045121","GO:0005524; GO:0008384; GO:0016301; GO:0000166; GO:0005515; GO:0046982; GO:0042803; GO:0004672; GO:0004674; GO:0097110; GO:0016740; GO:1990459; GO:0042802; GO:0019901; GO:0106310","GO:0009653; GO:0071276; GO:0034614; GO:0071356; GO:0098586; GO:0007249; GO:0007252; GO:0006955; GO:0006954; GO:0045087; GO:0032088; GO:0038061; GO:0018105; GO:0016310; GO:0045893; GO:0043123; GO:0032727; GO:0051092; GO:0045944; GO:0006468; GO:0050896; GO:0009615; GO:0033209; GO:0002479; GO:0030866; GO:0038095; GO:0070498; GO:1903347; GO:0035509; GO:0072659; GO:1903140; GO:0042325; GO:0031399; GO:0010803; GO:0002223; GO:0051403; GO:0050852","PTHR22969:SF13; PTHR22969:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1974|UniProtKB=O15111; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5960|UniProtKB=O14920","P00053; P00010; P00036; P00047; P00054; P00031; P00006"]
["IKK beta",null,"IKBKB","87","rb",null,1,1.1000000000000001,8,8,1,8,"# 0671",".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","T cell activation; B cell activation; Interleukin signaling pathway; PDGF signaling pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA","antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cellular response to tumor necrosis factor; cortical actin cytoskeleton organization; Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; inflammatory response; innate immune response; interleukin-1-mediated signaling pathway; negative regulation of bicellular tight junction assembly; negative regulation of myosin-light-chain-phosphatase activity; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; protein localization to plasma membrane; protein phosphorylation; regulation of establishment of endothelial barrier; regulation of phosphorylation; regulation of protein modification process; regulation of tumor necrosis factor-mediated signaling pathway; response to stimulus; response to virus; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway","ATP binding; identical protein binding; IkappaB kinase activity; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; scaffold protein binding; transferase activity; transferrin receptor binding","CD40 receptor complex; cytoplasm; cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; membrane; membrane raft; nucleus","NFkB signaling","inhibitor of nuclear factor kappa B kinase subunit beta","http://www.ncbi.nlm.nih.gov/gene/?term=3551","3551","16150",null,null,null,null,"O14920","A0A0R4J0T4","A0A8I5ZJG2","A0A8I3MZ82","A0A287A5Q1","F6SHB2","GO:0035631; GO:0005737; GO:0009898; GO:0005829; GO:0008385; GO:0016020; GO:0045121; GO:0005634","GO:0005524; GO:0042802; GO:0008384; GO:0016301; GO:0000166; GO:0005515; GO:0046982; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0097110; GO:0016740; GO:1990459","GO:0002479; GO:0071356; GO:0030866; GO:0038095; GO:0007249; GO:0007252; GO:0006954; GO:0045087; GO:0070498; GO:1903347; GO:0035509; GO:0018105; GO:0016310; GO:0045893; GO:0043123; GO:0051092; GO:0045944; GO:0072659; GO:0006468; GO:1903140; GO:0042325; GO:0031399; GO:0010803; GO:0050896; GO:0009615; GO:0002223; GO:0051403; GO:0050852; GO:0033209","PTHR22969:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5960|UniProtKB=O14920","P00053; P00010; P00036; P00047; P00054; P00031; P00006"]
["IKK epsilon",null,"IKBKE","80","rb",null,2,2,1,1,3,8,"# 1307",".APO., .CD., .CSP., .DDR., .DI., .HEPB., .IIR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .NFKB., .OP., .OPA., .OT., .ST., .TOLL., .TRASR., .VIR.","Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON","cellular response to DNA damage stimulus; cellular response to virus; defense response to virus; gene expression; I-kappaB phosphorylation; immune response; interleukin-17-mediated signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; mRNA stabilization; NIK/NF-kappaB signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA-binding transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of lipid storage; positive regulation of type I interferon-mediated signaling pathway; protein phosphorylation; regulation of protein-containing complex assembly; response to interferon-beta; response to type I interferon; type I interferon-mediated signaling pathway","ATP binding; identical protein binding; IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding; K63-linked polyubiquitin modification-dependent protein binding; kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase binding","cytoplasm; cytosol; mitochondrial membrane; nucleoplasm; nucleus; PML body; serine/threonine protein kinase complex","NFkB signaling","inhibitor of nuclear factor kappa B kinase subunit epsilon","http://www.ncbi.nlm.nih.gov/gene/?term=9641","9641","56489","363984",null,null,"695607","Q14164","Q9R0T8","D4A5E7","A0A8P0P6H3",null,"G7MER5","GO:0005737; GO:0005829; GO:0031966; GO:0005654; GO:0005634; GO:0016605; GO:1902554","GO:0005524; GO:0042802; GO:0008384; GO:0036435; GO:0070530; GO:0016301; GO:0004704; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004674; GO:0016740; GO:0031625","GO:0006974; GO:0098586; GO:0051607; GO:0010467; GO:0007252; GO:0006955; GO:0097400; GO:0008630; GO:0048255; GO:0038061; GO:0018105; GO:0016310; GO:0051091; GO:0043123; GO:0010884; GO:0060340; GO:0006468; GO:0043254; GO:0035456; GO:0034340; GO:0060337","PTHR22969:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=14552|UniProtKB=Q14164","P00054; P00031"]
["IKK epsilon - phospho","Ser172","IKBKE","80","rb",null,2.1,4,4,4,3,8,"# 1327",".APO., .CD., .CSP., .DDR., .DI., .HEPB., .IIR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .NFKB., .OP., .OPA., .OT., .ST., .TOLL., .TRASR., .VIR.","Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON","cellular response to DNA damage stimulus; cellular response to virus; defense response to virus; gene expression; I-kappaB phosphorylation; immune response; interleukin-17-mediated signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; mRNA stabilization; NIK/NF-kappaB signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA-binding transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of lipid storage; positive regulation of type I interferon-mediated signaling pathway; protein phosphorylation; regulation of protein-containing complex assembly; response to interferon-beta; response to type I interferon; type I interferon-mediated signaling pathway","ATP binding; identical protein binding; IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding; K63-linked polyubiquitin modification-dependent protein binding; kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase binding","cytoplasm; cytosol; mitochondrial membrane; nucleoplasm; nucleus; PML body; serine/threonine protein kinase complex","NFkB signaling","inhibitor of nuclear factor kappa B kinase subunit epsilon","http://www.ncbi.nlm.nih.gov/gene/?term=9641","9641","56489","363984",null,null,"695607","Q14164","Q9R0T8","D4A5E7","A0A8P0P6H3",null,"G7MER5","GO:0005737; GO:0005829; GO:0031966; GO:0005654; GO:0005634; GO:0016605; GO:1902554","GO:0005524; GO:0042802; GO:0008384; GO:0036435; GO:0070530; GO:0016301; GO:0004704; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004674; GO:0016740; GO:0031625","GO:0006974; GO:0098586; GO:0051607; GO:0010467; GO:0007252; GO:0006955; GO:0097400; GO:0008630; GO:0048255; GO:0038061; GO:0018105; GO:0016310; GO:0051091; GO:0043123; GO:0010884; GO:0060340; GO:0006468; GO:0043254; GO:0035456; GO:0034340; GO:0060337","PTHR22969:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=14552|UniProtKB=Q14164","P00054; P00031"]
["IKK gamma",null,"IKBKG","48","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0669",".ALZ., .AML., .APH., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .DDR., .DI., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OT., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.",null,"NF-KAPPA-B ESSENTIAL MODULATOR","anoikis; apoptotic process; cellular response to DNA damage stimulus; establishment of vesicle localization; I-kappaB kinase/NF-kappaB signaling; immune response; inflammatory response; innate immune response; negative regulation of neuron death; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of macroautophagy; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell receptor signaling pathway; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; regulation of I-kappaB kinase/NF-kappaB signaling; response to virus; T cell receptor signaling pathway","identical protein binding; K63-linked polyubiquitin modification-dependent protein binding; linear polyubiquitin binding; metal ion binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; transferrin receptor binding; ubiquitin protein ligase binding","cytoplasm; cytosol; IkappaB kinase complex; mitotic spindle; nucleoplasm; nucleus; protein-containing complex; spindle pole; ubiquitin ligase complex","NFkB signaling","inhibitor of nuclear factor kappa B kinase regulatory subunit gamma","http://www.ncbi.nlm.nih.gov/gene/?term=8517","8517","16151","309295",null,"100127355",null,"Q9Y6K9","O88522","A0A8I6AH74",null,"A9QT41","A0A5F7ZUK6","GO:0005737; GO:0005829; GO:0008385; GO:0072686; GO:0005654; GO:0005634; GO:0032991; GO:0000922; GO:0000151","GO:0042802; GO:0070530; GO:1990450; GO:0046872; GO:0005515; GO:0019904; GO:0046982; GO:0042803; GO:1990459; GO:0031625","GO:0043276; GO:0006915; GO:0006974; GO:0051650; GO:0007249; GO:0006955; GO:0006954; GO:0045087; GO:1901215; GO:0043123; GO:0016239; GO:0051092; GO:0050862; GO:0045944; GO:0065003; GO:0043122; GO:0009615; GO:0050852","PTHR31553:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5961|UniProtKB=Q9Y6K9"]
["IKK gamma",null,"IKBKG","48","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1229",".ALZ., .AML., .APH., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .DDR., .DI., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OT., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.",null,"NF-KAPPA-B ESSENTIAL MODULATOR","anoikis; apoptotic process; cellular response to DNA damage stimulus; establishment of vesicle localization; I-kappaB kinase/NF-kappaB signaling; immune response; inflammatory response; innate immune response; negative regulation of neuron death; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of macroautophagy; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell receptor signaling pathway; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; regulation of I-kappaB kinase/NF-kappaB signaling; response to virus; T cell receptor signaling pathway","identical protein binding; K63-linked polyubiquitin modification-dependent protein binding; linear polyubiquitin binding; metal ion binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; transferrin receptor binding; ubiquitin protein ligase binding","cytoplasm; cytosol; IkappaB kinase complex; mitotic spindle; nucleoplasm; nucleus; protein-containing complex; spindle pole; ubiquitin ligase complex","NFkB signaling","inhibitor of nuclear factor kappa B kinase regulatory subunit gamma","http://www.ncbi.nlm.nih.gov/gene/?term=8517","8517","16151","309295",null,"100127355",null,"Q9Y6K9","O88522","A0A8I6AH74",null,"A9QT41","A0A5F7ZUK6","GO:0005737; GO:0005829; GO:0008385; GO:0072686; GO:0005654; GO:0005634; GO:0032991; GO:0000922; GO:0000151","GO:0042802; GO:0070530; GO:1990450; GO:0046872; GO:0005515; GO:0019904; GO:0046982; GO:0042803; GO:1990459; GO:0031625","GO:0043276; GO:0006915; GO:0006974; GO:0051650; GO:0007249; GO:0006955; GO:0006954; GO:0045087; GO:1901215; GO:0043123; GO:0016239; GO:0051092; GO:0050862; GO:0045944; GO:0065003; GO:0043122; GO:0009615; GO:0050852","PTHR31553:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5961|UniProtKB=Q9Y6K9"]
["IL-33",null,"IL33","31","ms",null,7,4,"n/a","n/a","n/a","n/a","# 1623",".APO., .CCP., .CD., .CP., .CSP., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .LMIG., .MIG., .OP., .OT., .TRASR., .VIR.",null,"INTERLEUKIN-33","cellular response to mechanical stimulus; defense response to virus; extrinsic apoptotic signaling pathway; gene expression; interleukin-33-mediated signaling pathway; macrophage activation involved in immune response; macrophage differentiation; microglial cell activation involved in immune response; microglial cell proliferation; negative regulation of immunoglobulin production; negative regulation of leukocyte migration; negative regulation of macrophage proliferation; negative regulation of T-helper 1 type immune response; negative regulation of transcription by RNA polymerase II; negative regulation of type II interferon production; positive regulation of CD80 production; positive regulation of CD86 production; positive regulation of cellular defense response; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of gene expression; positive regulation of immunoglobulin production; positive regulation of inflammatory response; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; positive regulation of MHC class I biosynthetic process; positive regulation of MHC class II biosynthetic process; positive regulation of neuroinflammatory response; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of oligodendrocyte differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of type 2 immune response; protein import into nucleus; regulation of sensory perception of pain; type 2 immune response; wound healing","cytokine activity; interleukin-33 receptor binding; protein binding","chromosome; cytoplasm; cytoplasmic vesicle; extracellular region; extracellular space; intracellular membrane-bounded organelle; nucleoplasm; nucleus; transport vesicle",null,"interleukin 33","http://www.ncbi.nlm.nih.gov/gene/?term=90865","90865","77125","361749",null,null,"717301","O95760","Q8BVZ5","Q66H70","A0A8I3PZM8","K7GRC7","F7DLG4","GO:0005694; GO:0005737; GO:0031410; GO:0005576; GO:0005615; GO:0043231; GO:0005654; GO:0005634; GO:0030133","GO:0005125; GO:0002112; GO:0005515","GO:0071260; GO:0051607; GO:0097191; GO:0010467; GO:0038172; GO:0002281; GO:0030225; GO:0002282; GO:0061518; GO:0002638; GO:0002686; GO:0120042; GO:0002826; GO:0000122; GO:0032689; GO:0150145; GO:0150142; GO:0010186; GO:0032722; GO:0001819; GO:0010628; GO:0002639; GO:0050729; GO:0032736; GO:0032753; GO:0032754; GO:0032755; GO:0043032; GO:0045345; GO:0045348; GO:0150078; GO:0051770; GO:0048714; GO:0032436; GO:0045944; GO:0032760; GO:0002830; GO:0006606; GO:0051930; GO:0042092; GO:0042060","PTHR21114:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16028|UniProtKB=O95760"]
["ILK",null,"ILK","51","rb",null,2,1,8,8,2,2,"TK # 112",".BMP., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .EMC., .IMUF., .INFM., .INT., .MIG., .NFKB., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .ST., .TNF., .TRASR., .WNT.","Integrin signalling pathway","INTEGRIN-LINKED PROTEIN KINASE","branching involved in ureteric bud morphogenesis; cell morphogenesis; cell population proliferation; cell projection organization; cell-matrix adhesion; establishment or maintenance of epithelial cell apical/basal polarity; fibroblast migration; integrin-mediated signaling pathway; myelination in peripheral nervous system; negative regulation of neural precursor cell proliferation; nerve development; neural precursor cell proliferation; outflow tract morphogenesis; peptidyl-serine phosphorylation; phosphorylation; platelet aggregation; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein phosphorylation; positive regulation of signal transduction; positive regulation of substrate adhesion-dependent cell spreading; protein kinase B signaling; protein phosphorylation; Schwann cell development; substrate adhesion-dependent cell spreading; tumor necrosis factor-mediated signaling pathway","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","anchoring junction; cell projection; cytoplasm; cytosol; focal adhesion; lamellipodium; membrane; nucleoplasm; plasma membrane; sarcomere; stress fiber","Cell-cell interaction","integrin linked kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3611","3611","16202","170922",null,null,null,"Q13418","O55222","Q99J82","A0A8P0NMJ7","A0A287A8C3","A0A1D5R325","GO:0070161; GO:0042995; GO:0005737; GO:0005829; GO:0005925; GO:0030027; GO:0016020; GO:0005654; GO:0005886; GO:0030017; GO:0001725","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0001658; GO:0000902; GO:0008283; GO:0030030; GO:0007160; GO:0045197; GO:0010761; GO:0007229; GO:0022011; GO:2000178; GO:0021675; GO:0061351; GO:0003151; GO:0018105; GO:0016310; GO:0070527; GO:0030513; GO:0090263; GO:0008284; GO:0045893; GO:1901224; GO:0045669; GO:0042327; GO:0001934; GO:0009967; GO:1900026; GO:0043491; GO:0006468; GO:0014044; GO:0034446; GO:0033209","PTHR44329:SF57","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6040|UniProtKB=Q13418","P00034"]
["ILK - phospho","Ser246","ILK","50","rb",null,2,2,1,1,3,3,"# 1293",".BMP., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .EMC., .IMUF., .INFM., .INT., .MIG., .NFKB., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .ST., .TNF., .TRASR., .WNT.","Integrin signalling pathway","INTEGRIN-LINKED PROTEIN KINASE","branching involved in ureteric bud morphogenesis; cell morphogenesis; cell population proliferation; cell projection organization; cell-matrix adhesion; establishment or maintenance of epithelial cell apical/basal polarity; fibroblast migration; integrin-mediated signaling pathway; myelination in peripheral nervous system; negative regulation of neural precursor cell proliferation; nerve development; neural precursor cell proliferation; outflow tract morphogenesis; peptidyl-serine phosphorylation; phosphorylation; platelet aggregation; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein phosphorylation; positive regulation of signal transduction; positive regulation of substrate adhesion-dependent cell spreading; protein kinase B signaling; protein phosphorylation; Schwann cell development; substrate adhesion-dependent cell spreading; tumor necrosis factor-mediated signaling pathway","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","anchoring junction; cell projection; cytoplasm; cytosol; focal adhesion; lamellipodium; membrane; nucleoplasm; plasma membrane; sarcomere; stress fiber","Cell-cell adhesion","integrin linked kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3611","3611","16202","170922",null,null,null,"Q13418","O55222","Q99J82","A0A8P0NMJ7","A0A287A8C3","A0A1D5R325","GO:0070161; GO:0042995; GO:0005737; GO:0005829; GO:0005925; GO:0030027; GO:0016020; GO:0005654; GO:0005886; GO:0030017; GO:0001725","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0001658; GO:0000902; GO:0008283; GO:0030030; GO:0007160; GO:0045197; GO:0010761; GO:0007229; GO:0022011; GO:2000178; GO:0021675; GO:0061351; GO:0003151; GO:0018105; GO:0016310; GO:0070527; GO:0030513; GO:0090263; GO:0008284; GO:0045893; GO:1901224; GO:0045669; GO:0042327; GO:0001934; GO:0009967; GO:1900026; GO:0043491; GO:0006468; GO:0014044; GO:0034446; GO:0033209","PTHR44329:SF57","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6040|UniProtKB=Q13418","P00034"]
["ILK - phospho","Ser259","ILK","50","rb",null,2,2.1,8,2,3,3,"# 1300",".BMP., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .EMC., .IMUF., .INFM., .INT., .MIG., .NFKB., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .ST., .TNF., .TRASR., .WNT.","Integrin signalling pathway","INTEGRIN-LINKED PROTEIN KINASE","branching involved in ureteric bud morphogenesis; cell morphogenesis; cell population proliferation; cell projection organization; cell-matrix adhesion; establishment or maintenance of epithelial cell apical/basal polarity; fibroblast migration; integrin-mediated signaling pathway; myelination in peripheral nervous system; negative regulation of neural precursor cell proliferation; nerve development; neural precursor cell proliferation; outflow tract morphogenesis; peptidyl-serine phosphorylation; phosphorylation; platelet aggregation; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein phosphorylation; positive regulation of signal transduction; positive regulation of substrate adhesion-dependent cell spreading; protein kinase B signaling; protein phosphorylation; Schwann cell development; substrate adhesion-dependent cell spreading; tumor necrosis factor-mediated signaling pathway","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","anchoring junction; cell projection; cytoplasm; cytosol; focal adhesion; lamellipodium; membrane; nucleoplasm; plasma membrane; sarcomere; stress fiber","Cell-cell adhesion","integrin linked kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3611","3611","16202","170922",null,null,null,"Q13418","O55222","Q99J82","A0A8P0NMJ7","A0A287A8C3","A0A1D5R325","GO:0070161; GO:0042995; GO:0005737; GO:0005829; GO:0005925; GO:0030027; GO:0016020; GO:0005654; GO:0005886; GO:0030017; GO:0001725","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0001658; GO:0000902; GO:0008283; GO:0030030; GO:0007160; GO:0045197; GO:0010761; GO:0007229; GO:0022011; GO:2000178; GO:0021675; GO:0061351; GO:0003151; GO:0018105; GO:0016310; GO:0070527; GO:0030513; GO:0090263; GO:0008284; GO:0045893; GO:1901224; GO:0045669; GO:0042327; GO:0001934; GO:0009967; GO:1900026; GO:0043491; GO:0006468; GO:0014044; GO:0034446; GO:0033209","PTHR44329:SF57","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6040|UniProtKB=Q13418","P00034"]
["ILK - phospho","Ser343","ILK","51","rb",null,2,6,4,4,4,4,"# 1290",".BMP., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .EMC., .IMUF., .INFM., .INT., .MIG., .NFKB., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .ST., .TNF., .TRASR., .WNT.","Integrin signalling pathway","INTEGRIN-LINKED PROTEIN KINASE","branching involved in ureteric bud morphogenesis; cell morphogenesis; cell population proliferation; cell projection organization; cell-matrix adhesion; establishment or maintenance of epithelial cell apical/basal polarity; fibroblast migration; integrin-mediated signaling pathway; myelination in peripheral nervous system; negative regulation of neural precursor cell proliferation; nerve development; neural precursor cell proliferation; outflow tract morphogenesis; peptidyl-serine phosphorylation; phosphorylation; platelet aggregation; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein phosphorylation; positive regulation of signal transduction; positive regulation of substrate adhesion-dependent cell spreading; protein kinase B signaling; protein phosphorylation; Schwann cell development; substrate adhesion-dependent cell spreading; tumor necrosis factor-mediated signaling pathway","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","anchoring junction; cell projection; cytoplasm; cytosol; focal adhesion; lamellipodium; membrane; nucleoplasm; plasma membrane; sarcomere; stress fiber","Cell-cell adhesion","integrin linked kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3611","3611","16202","170922",null,null,null,"Q13418","O55222","Q99J82","A0A8P0NMJ7","A0A287A8C3","A0A1D5R325","GO:0070161; GO:0042995; GO:0005737; GO:0005829; GO:0005925; GO:0030027; GO:0016020; GO:0005654; GO:0005886; GO:0030017; GO:0001725","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0001658; GO:0000902; GO:0008283; GO:0030030; GO:0007160; GO:0045197; GO:0010761; GO:0007229; GO:0022011; GO:2000178; GO:0021675; GO:0061351; GO:0003151; GO:0018105; GO:0016310; GO:0070527; GO:0030513; GO:0090263; GO:0008284; GO:0045893; GO:1901224; GO:0045669; GO:0042327; GO:0001934; GO:0009967; GO:1900026; GO:0043491; GO:0006468; GO:0014044; GO:0034446; GO:0033209","PTHR44329:SF57","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6040|UniProtKB=Q13418","P00034"]
["ILK - phospho","Thr173","ILK","51","rb",null,2,4,4,4,4,4,"# 1287",".BMP., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .EMC., .IMUF., .INFM., .INT., .MIG., .NFKB., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .ST., .TNF., .TRASR., .WNT.","Integrin signalling pathway","INTEGRIN-LINKED PROTEIN KINASE","branching involved in ureteric bud morphogenesis; cell morphogenesis; cell population proliferation; cell projection organization; cell-matrix adhesion; establishment or maintenance of epithelial cell apical/basal polarity; fibroblast migration; integrin-mediated signaling pathway; myelination in peripheral nervous system; negative regulation of neural precursor cell proliferation; nerve development; neural precursor cell proliferation; outflow tract morphogenesis; peptidyl-serine phosphorylation; phosphorylation; platelet aggregation; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein phosphorylation; positive regulation of signal transduction; positive regulation of substrate adhesion-dependent cell spreading; protein kinase B signaling; protein phosphorylation; Schwann cell development; substrate adhesion-dependent cell spreading; tumor necrosis factor-mediated signaling pathway","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","anchoring junction; cell projection; cytoplasm; cytosol; focal adhesion; lamellipodium; membrane; nucleoplasm; plasma membrane; sarcomere; stress fiber","Cell-cell adhesion","integrin linked kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3611","3611","16202","170922",null,null,null,"Q13418","O55222","Q99J82","A0A8P0NMJ7","A0A287A8C3","A0A1D5R325","GO:0070161; GO:0042995; GO:0005737; GO:0005829; GO:0005925; GO:0030027; GO:0016020; GO:0005654; GO:0005886; GO:0030017; GO:0001725","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0001658; GO:0000902; GO:0008283; GO:0030030; GO:0007160; GO:0045197; GO:0010761; GO:0007229; GO:0022011; GO:2000178; GO:0021675; GO:0061351; GO:0003151; GO:0018105; GO:0016310; GO:0070527; GO:0030513; GO:0090263; GO:0008284; GO:0045893; GO:1901224; GO:0045669; GO:0042327; GO:0001934; GO:0009967; GO:1900026; GO:0043491; GO:0006468; GO:0014044; GO:0034446; GO:0033209","PTHR44329:SF57","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6040|UniProtKB=Q13418","P00034"]
["ILK - phospho","Thr173","ILK","50","rb",null,2,2,1,1,3,3,"# 1294",".BMP., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .EMC., .IMUF., .INFM., .INT., .MIG., .NFKB., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .ST., .TNF., .TRASR., .WNT.","Integrin signalling pathway","INTEGRIN-LINKED PROTEIN KINASE","branching involved in ureteric bud morphogenesis; cell morphogenesis; cell population proliferation; cell projection organization; cell-matrix adhesion; establishment or maintenance of epithelial cell apical/basal polarity; fibroblast migration; integrin-mediated signaling pathway; myelination in peripheral nervous system; negative regulation of neural precursor cell proliferation; nerve development; neural precursor cell proliferation; outflow tract morphogenesis; peptidyl-serine phosphorylation; phosphorylation; platelet aggregation; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of NIK/NF-kappaB signaling; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein phosphorylation; positive regulation of signal transduction; positive regulation of substrate adhesion-dependent cell spreading; protein kinase B signaling; protein phosphorylation; Schwann cell development; substrate adhesion-dependent cell spreading; tumor necrosis factor-mediated signaling pathway","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","anchoring junction; cell projection; cytoplasm; cytosol; focal adhesion; lamellipodium; membrane; nucleoplasm; plasma membrane; sarcomere; stress fiber","Cell-cell adhesion","integrin linked kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3611","3611","16202","170922",null,null,null,"Q13418","O55222","Q99J82","A0A8P0NMJ7","A0A287A8C3","A0A1D5R325","GO:0070161; GO:0042995; GO:0005737; GO:0005829; GO:0005925; GO:0030027; GO:0016020; GO:0005654; GO:0005886; GO:0030017; GO:0001725","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0001658; GO:0000902; GO:0008283; GO:0030030; GO:0007160; GO:0045197; GO:0010761; GO:0007229; GO:0022011; GO:2000178; GO:0021675; GO:0061351; GO:0003151; GO:0018105; GO:0016310; GO:0070527; GO:0030513; GO:0090263; GO:0008284; GO:0045893; GO:1901224; GO:0045669; GO:0042327; GO:0001934; GO:0009967; GO:1900026; GO:0043491; GO:0006468; GO:0014044; GO:0034446; GO:0033209","PTHR44329:SF57","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6040|UniProtKB=Q13418","P00034"]
["IMP (BRAP, BRAP2, RNF52)",null,"BRAP","68","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0396",".CSP., .MAPK., .OP., .OPA., .OT., .RAS., .RTK., .ST., .UBI.",null,"BRCA1-ASSOCIATED PROTEIN","MAPK cascade; negative regulation of signal transduction; protein ubiquitination; Ras protein signal transduction","identical protein binding; metal ion binding; nuclear localization sequence binding; nucleic acid binding; protein binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding","cytoplasm; cytosol; nuclear membrane; nucleoplasm; ubiquitin ligase complex","MAPK signaling","BRCA1 associated protein","http://www.ncbi.nlm.nih.gov/gene/?term=8315","8315","72399","687346",null,null,null,"Q7Z569","Q99MP8","A0A8I5Y120","A0A8P0SDP8",null,"A0A5F8A555","GO:0005737; GO:0005829; GO:0031965; GO:0005654; GO:0000151","GO:0042802; GO:0046872; GO:0008139; GO:0003676; GO:0005515; GO:0016740; GO:0061630; GO:0004842; GO:0008270","GO:0000165; GO:0009968; GO:0016567; GO:0007265","PTHR24007:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1099|UniProtKB=Q7Z569"]
["INPP4b",null,"INPP4B","110","rb",null,2,4,4,4,4,4,"# 1541",".CSP., .OPA., .ST.",null,"INOSITOL POLYPHOSPHATE 4-PHOSPHATASE TYPE II","inositol phosphate dephosphorylation; inositol phosphate metabolic process; lipid metabolic process; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; signal transduction","hydrolase activity; inositol-1,3,4-trisphosphate 4-phosphatase activity; inositol-3,4-bisphosphate 4-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; protein binding","cytoplasm; cytosol","Ca / cAMP / lipid signaling","inositol polyphosphate-4-phosphatase type II B","http://www.ncbi.nlm.nih.gov/gene/?term=8821","8821","234515","116699",null,"100511393",null,"O15327","Q6P1Y8","Q9QWG5","A0A8I3PF00","A0A287BHL1","A0A1D5QDV8","GO:0005737; GO:0005829","GO:0016787; GO:0017161; GO:0052828; GO:0016316; GO:0005515","GO:0046855; GO:0043647; GO:0006629; GO:0006661; GO:0046856; GO:0036092; GO:0007165","PTHR12187:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6075|UniProtKB=O15327"]
["INSL4",null,"INSL4","15","rb",null,2,2,1,1,3,3,"# 0960",".CCP., .CP., .CSP., .OP., .OPA., .ST.",null,"EARLY PLACENTA INSULIN-LIKE PEPTIDE","cell-cell signaling; positive regulation of chorionic trophoblast cell proliferation; signal transduction","hormone activity; insulin-like growth factor receptor binding; signaling receptor binding","extracellular region; extracellular space","Development","insulin like 4","http://www.ncbi.nlm.nih.gov/gene/?term=3641","3641",null,null,null,null,null,"Q14641",null,null,null,null,null,"GO:0005576; GO:0005615","GO:0005179; GO:0005159; GO:0005102","GO:0007267; GO:1901384; GO:0007165","PTHR12004:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6087|UniProtKB=Q14641"]
["Integrin alpha1 subunit",null,"ITGA1","130","rb",null,6,6,"n/a","n/a","n/a","n/a","BG/MP # 126",".APO., .CCP., .CD., .CP., .CSP., .EGFR., .ErbB., .IMUR., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST.","Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway","INTEGRIN ALPHA-1","cell adhesion; cell adhesion mediated by integrin; cell chemotaxis; cell-cell adhesion; cell-matrix adhesion; cellular extravasation; integrin-mediated signaling pathway; negative regulation of cell population proliferation; negative regulation of epidermal growth factor receptor signaling pathway; neuron projection morphogenesis; neutrophil chemotaxis; positive regulation of MAPK cascade; positive regulation of neuron apoptotic process; positive regulation of phosphoprotein phosphatase activity; vasodilation","collagen binding; collagen binding involved in cell-matrix adhesion; integrin binding; metal ion binding; protein binding; protein phosphatase binding; signaling receptor binding","acrosomal vesicle; basal part of cell; cell surface; external side of plasma membrane; extracellular exosome; focal adhesion; integrin alpha1-beta1 complex; integrin complex; membrane; membrane raft; neuron projection; perikaryon; plasma membrane","Adhesion","integrin subunit alpha 1","http://www.ncbi.nlm.nih.gov/gene/?term=3672","3672","109700","25118","489210",null,null,"P56199","Q3V3R4","P18614","A0A8I3MAW3","A0A5G2R836","A0A5F8ABI6","GO:0001669; GO:0045178; GO:0009986; GO:0009897; GO:0070062; GO:0005925; GO:0034665; GO:0008305; GO:0016020; GO:0045121; GO:0043005; GO:0043204; GO:0005886","GO:0005518; GO:0098639; GO:0005178; GO:0046872; GO:0005515; GO:0019903; GO:0005102","GO:0007155; GO:0033627; GO:0060326; GO:0098609; GO:0007160; GO:0045123; GO:0007229; GO:0008285; GO:0042059; GO:0048812; GO:0030593; GO:0043410; GO:0043525; GO:0032516; GO:0042311","PTHR23220:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6134|UniProtKB=P56199","P06664; P00034"]
["Integrin alpha5",null,"ITGA5","150","ms",null,1,4,4,4,4,4,"# 0515",".ANG., .APO., .CANCER., .CD., .CSP., .IMUR., .INT., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .VEGFS., .VIR.","Integrin signalling pathway","INTEGRIN ALPHA-5","angiogenesis; CD40 signaling pathway; cell adhesion; cell adhesion mediated by integrin; cell-cell adhesion; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; endodermal cell differentiation; female pregnancy; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; memory; negative regulation of anoikis; positive regulation of cell migration; positive regulation of cell-substrate adhesion; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of sprouting angiogenesis; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of angiogenesis; viral entry into host cell; wound healing, spreading of epidermal cells","cell adhesion molecule binding; epidermal growth factor receptor binding; integrin binding; metal ion binding; platelet-derived growth factor receptor binding; protein binding; vascular endothelial growth factor receptor 2 binding; virus receptor activity","alphav-beta3 integrin-vitronectin complex; anchoring junction; cell surface; cell-cell junction; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; external side of plasma membrane; focal adhesion; glutamatergic synapse; Golgi apparatus; integrin alpha5-beta1 complex; integrin complex; membrane; plasma membrane; postsynaptic membrane; ruffle; ruffle membrane; synapse","Adhesion","integrin subunit alpha 5","http://www.ncbi.nlm.nih.gov/gene/?term=3678","3678","16402","315346","486493",null,null,"P08648","P11688","A0A0G2K1E2","A0A8I3S2B2","A0A5G2QK84","F7GXE0","GO:0071062; GO:0070161; GO:0009986; GO:0005911; GO:0005737; GO:0031410; GO:0005783; GO:0009897; GO:0005925; GO:0098978; GO:0005794; GO:0034674; GO:0008305; GO:0016020; GO:0005886; GO:0045211; GO:0001726; GO:0032587; GO:0045202","GO:0050839; GO:0005154; GO:0005178; GO:0046872; GO:0005161; GO:0005515; GO:0043184; GO:0001618","GO:0001525; GO:0023035; GO:0007155; GO:0033627; GO:0098609; GO:0033631; GO:0007160; GO:0031589; GO:0007044; GO:0035987; GO:0007565; GO:0007157; GO:0034113; GO:0007229; GO:0007159; GO:0007613; GO:2000811; GO:0030335; GO:0010811; GO:0050731; GO:1903672; GO:0030949; GO:0045765; GO:0046718; GO:0035313","PTHR23220:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6141|UniProtKB=P08648","P00034"]
["Integrin alpha6",null,"ITGA6","150, 125","rb",null,4,2,"n/a","n/a","n/a","n/a","# 1990",".APO., .CANCER., .CANPTHW., .CD., .CSP., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TRASR.","Integrin signalling pathway","INTEGRIN ALPHA-6","cell adhesion; cell adhesion mediated by integrin; cell-cell adhesion; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; ectodermal cell differentiation; integrin-mediated signaling pathway; leukocyte migration; nail development; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of GTPase activity; positive regulation of neuron projection development; positive regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; skin morphogenesis","cadherin binding; insulin-like growth factor I binding; integrin binding; metal ion binding; neuregulin binding; protein binding","cell surface; external side of plasma membrane; focal adhesion; integrin complex; membrane; plasma membrane",null,"integrin subunit alpha 6","http://www.ncbi.nlm.nih.gov/gene/?term=3655","3655","16403",null,null,null,"697643","P23229","Q61739","A0A8I6A5C8","A0A8I3PZE7","A0A8W4FC88","F7BZD3","GO:0009986; GO:0009897; GO:0005925; GO:0008305; GO:0016020; GO:0005886","GO:0045296; GO:0031994; GO:0005178; GO:0046872; GO:0038132; GO:0005515","GO:0007155; GO:0033627; GO:0098609; GO:0007160; GO:0031589; GO:0007044; GO:0010668; GO:0007229; GO:0050900; GO:0035878; GO:2001237; GO:0043065; GO:0030335; GO:0043547; GO:0010976; GO:0042327; GO:0045944; GO:0043589","PTHR23220:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6142|UniProtKB=P23229","P00034"]
["Integrin beta1",null,"ITGB1","130","ms",null,1,1.1000000000000001,1.1000000000000001,1,1,1,"# 0516",".ANG., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .IMFR., .IMUF., .IMUR., .INFM., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .PLAT., .RAS., .RTK., .SCLC., .ST., .TGFB., .VIR.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","INTEGRIN BETA-1","axon extension; B cell differentiation; basement membrane organization; calcium-independent cell-matrix adhesion; cardiac cell fate specification; cardiac muscle cell differentiation; cardiac muscle cell myoblast differentiation; CD40 signaling pathway; cell adhesion; cell adhesion mediated by integrin; cell migration; cell migration involved in sprouting angiogenesis; cell population proliferation; cell projection organization; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cellular defense response; cellular response to low-density lipoprotein particle stimulus; dendrite morphogenesis; establishment of mitotic spindle orientation; formation of radial glial scaffolds; G1/S transition of mitotic cell cycle; germ cell migration; heterotypic cell-cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; in utero embryonic development; integrin-mediated signaling pathway; lamellipodium assembly; leukocyte cell-cell adhesion; leukocyte tethering or rolling; maintenance of blood-brain barrier; mesodermal cell differentiation; modulation of chemical synaptic transmission; muscle organ development; myoblast differentiation; myoblast fate specification; myoblast fusion; negative regulation of anoikis; negative regulation of neuron differentiation; negative regulation of Rho protein signal transduction; neuroblast proliferation; neuron differentiation; neuron projection development; phagocytosis; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of fibroblast migration; positive regulation of glutamate uptake involved in transmission of nerve impulse; positive regulation of GTPase activity; positive regulation of neuroblast proliferation; positive regulation of protein kinase B signaling; positive regulation of protein localization to plasma membrane; positive regulation of signaling receptor activity; positive regulation of wound healing; reactive gliosis; receptor internalization; regulation of cell cycle; regulation of collagen catabolic process; regulation of inward rectifier potassium channel activity; regulation of spontaneous synaptic transmission; regulation of synapse pruning; sarcomere organization; stress fiber assembly; transforming growth factor beta receptor signaling pathway; viral entry into host cell; visual learning; wound healing, spreading of epidermal cells","actin binding; cadherin binding; cell adhesion molecule binding; collagen binding involved in cell-matrix adhesion; coreceptor activity; C-X3-C chemokine binding; fibronectin binding; integrin binding; laminin binding; metal ion binding; protease binding; protein binding; protein heterodimerization activity; protein tyrosine kinase binding; protein-containing complex binding; virus receptor activity","anchoring junction; cell projection; cell surface; cerebellar climbing fiber to Purkinje cell synapse; cleavage furrow; cytoplasm; cytoplasmic vesicle; dendritic spine; endosome; endosome membrane; external side of plasma membrane; extracellular exosome; filopodium; focal adhesion; glial cell projection; glutamatergic synapse; integrin alpha10-beta1 complex; integrin alpha11-beta1 complex; integrin alpha1-beta1 complex; integrin alpha2-beta1 complex; integrin alpha3-beta1 complex; integrin alpha4-beta1 complex; integrin alpha5-beta1 complex; integrin alpha7-beta1 complex; integrin alpha8-beta1 complex; integrin complex; intercalated disc; lamellipodium; melanosome; membrane; membrane raft; myelin sheath abaxonal region; neuromuscular junction; perinuclear region of cytoplasm; plasma membrane; receptor complex; recycling endosome; ruffle; ruffle membrane; sarcolemma; Schaffer collateral - CA1 synapse; synapse; synaptic membrane","Adhesion","integrin subunit beta 1","http://www.ncbi.nlm.nih.gov/gene/?term=3688","3688","16412","24511",null,null,null,"P05556","P09055","A0A0G2JSK5","A0A8I3MGZ7","A0A480ITD5","A0A5F8ABB7","GO:0070161; GO:0042995; GO:0009986; GO:0150053; GO:0032154; GO:0005737; GO:0031410; GO:0043197; GO:0005768; GO:0010008; GO:0009897; GO:0070062; GO:0030175; GO:0005925; GO:0097386; GO:0098978; GO:0034680; GO:0034681; GO:0034665; GO:0034666; GO:0034667; GO:0034668; GO:0034674; GO:0034677; GO:0034678; GO:0008305; GO:0014704; GO:0030027; GO:0042470; GO:0016020; GO:0045121; GO:0035748; GO:0031594; GO:0048471; GO:0005886; GO:0043235; GO:0055037; GO:0001726; GO:0032587; GO:0042383; GO:0098685; GO:0045202; GO:0097060","GO:0003779; GO:0045296; GO:0050839; GO:0098639; GO:0015026; GO:0019960; GO:0001968; GO:0005178; GO:0043236; GO:0046872; GO:0002020; GO:0005515; GO:0046982; GO:1990782; GO:0044877; GO:0001618","GO:0048675; GO:0030183; GO:0071711; GO:0007161; GO:0060912; GO:0055007; GO:0060379; GO:0023035; GO:0007155; GO:0033627; GO:0016477; GO:0002042; GO:0008283; GO:0030030; GO:0033631; GO:0007160; GO:0031589; GO:0006968; GO:0071404; GO:0048813; GO:0000132; GO:0021943; GO:0000082; GO:0008354; GO:0034113; GO:0007156; GO:0001701; GO:0007229; GO:0030032; GO:0007159; GO:0050901; GO:0035633; GO:0048333; GO:0050804; GO:0007517; GO:0045445; GO:0048626; GO:0007520; GO:2000811; GO:0045665; GO:0035024; GO:0007405; GO:0030182; GO:0031175; GO:0006909; GO:0045766; GO:0043065; GO:0030335; GO:0010763; GO:0051951; GO:0043547; GO:0002052; GO:0051897; GO:1903078; GO:2000273; GO:0090303; GO:0150103; GO:0031623; GO:0051726; GO:0010710; GO:1901979; GO:0150003; GO:1905806; GO:0045214; GO:0043149; GO:0007179; GO:0046718; GO:0008542; GO:0035313","PTHR10082:SF28","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6153|UniProtKB=P05556","P06959; P06664; P00034; P00031"]
["Integrin beta3",null,"ITGB3","104","ms",null,2,4,4,4,4,4,"# 0517",".ANG., .CANCER., .CCP., .CP., .CSP., .DRR., .GPCR., .GPROT., .IMUR., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .ST., .TRASR., .VEGFS., .VIR.","Integrin signalling pathway; Blood coagulation","INTEGRIN BETA-3","activation of protein kinase activity; angiogenesis involved in wound healing; apolipoprotein A-I-mediated signaling pathway; apoptotic cell clearance; blood coagulation; cell adhesion; cell adhesion mediated by integrin; cell migration; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; cellular response to insulin-like growth factor stimulus; cellular response to mechanical stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to xenobiotic stimulus; embryo implantation; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; maintenance of postsynaptic specialization structure; mesodermal cell differentiation; negative chemotaxis; negative regulation of cell death; negative regulation of lipid storage; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor activity; negative regulation of macrophage derived foam cell differentiation; platelet activation; platelet aggregation; platelet-derived growth factor receptor signaling pathway; positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway; positive regulation of angiogenesis; positive regulation of bone resorption; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell-matrix adhesion; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast migration; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of glomerular mesangial cell proliferation; positive regulation of leukocyte migration; positive regulation of osteoblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of T cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of actin cytoskeleton organization; regulation of bone resorption; regulation of extracellular matrix organization; regulation of G protein-coupled receptor signaling pathway; regulation of postsynaptic neurotransmitter receptor diffusion trapping; regulation of postsynaptic neurotransmitter receptor internalization; regulation of protein localization; regulation of protein tyrosine kinase activity; regulation of release of sequestered calcium ion into cytosol; regulation of serotonin uptake; regulation of trophoblast cell migration; response to activity; response to platelet-derived growth factor; response to radiation; smooth muscle cell migration; substrate adhesion-dependent cell spreading; tube development; viral entry into host cell; wound healing","cell adhesion molecule binding; coreceptor activity; C-X3-C chemokine binding; enzyme binding; extracellular matrix binding; fibrinogen binding; fibroblast growth factor binding; fibronectin binding; identical protein binding; insulin-like growth factor I binding; integrin binding; neuregulin binding; platelet-derived growth factor receptor binding; protease binding; protein binding; protein disulfide isomerase activity; protein kinase C binding; vascular endothelial growth factor receptor 2 binding; virus receptor activity","alpha9-beta1 integrin-ADAM8 complex; alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; alphav-beta3 integrin-PKCalpha complex; alphav-beta3 integrin-vitronectin complex; anchoring junction; apical plasma membrane; cell projection; cell surface; cell-cell junction; external side of plasma membrane; extracellular exosome; filopodium membrane; focal adhesion; glutamatergic synapse; glycinergic synapse; integrin alphav-beta3 complex; integrin complex; lamellipodium membrane; melanosome; membrane; microvillus membrane; nucleoplasm; nucleus; plasma membrane; platelet alpha granule membrane; postsynaptic membrane; protein-containing complex; receptor complex; ruffle membrane; synapse; synaptic membrane","Adhesion","integrin subunit beta 3","http://www.ncbi.nlm.nih.gov/gene/?term=3690","3690","16416","29302",null,null,null,"P05106","O54890","Q8R2H2","O97702","A0A5G2R7K7","F7FG54","GO:0071133; GO:0035868; GO:0035867; GO:0035866; GO:0071062; GO:0070161; GO:0016324; GO:0042995; GO:0009986; GO:0005911; GO:0009897; GO:0070062; GO:0031527; GO:0005925; GO:0098978; GO:0098690; GO:0034683; GO:0008305; GO:0031258; GO:0042470; GO:0016020; GO:0031528; GO:0005654; GO:0005634; GO:0005886; GO:0031092; GO:0045211; GO:0032991; GO:0043235; GO:0032587; GO:0045202; GO:0097060","GO:0050839; GO:0015026; GO:0019960; GO:0019899; GO:0050840; GO:0070051; GO:0017134; GO:0001968; GO:0042802; GO:0031994; GO:0005178; GO:0038132; GO:0005161; GO:0002020; GO:0005515; GO:0003756; GO:0005080; GO:0043184; GO:0001618","GO:0032147; GO:0060055; GO:0038027; GO:0043277; GO:0007596; GO:0007155; GO:0033627; GO:0016477; GO:0007160; GO:0031589; GO:0007044; GO:1990314; GO:0071260; GO:0036120; GO:0071466; GO:0007566; GO:0034113; GO:0007229; GO:0098880; GO:0048333; GO:0050919; GO:0060548; GO:0010888; GO:0032369; GO:0050748; GO:1905598; GO:0010745; GO:0030168; GO:0070527; GO:0048008; GO:1900731; GO:0045766; GO:0045780; GO:0033630; GO:0030335; GO:0001954; GO:0010595; GO:0001938; GO:0070374; GO:0010763; GO:0048146; GO:0010628; GO:0072126; GO:0002687; GO:0033690; GO:0050731; GO:0001934; GO:0014911; GO:0048661; GO:1900026; GO:2000406; GO:0030949; GO:0032956; GO:0045124; GO:1903053; GO:0008277; GO:0150054; GO:0099149; GO:0032880; GO:0061097; GO:0051279; GO:0051611; GO:1901163; GO:0014823; GO:0036119; GO:0009314; GO:0014909; GO:0034446; GO:0035295; GO:0046718; GO:0042060","PTHR10082:SF25","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6156|UniProtKB=P05106","P00034; P00011"]
["IRAK1",null,"IRAK1","105, 78","rb",null,1,4,4,4,4,4,"# 1206",".CCP., .CP., .CSP., .DI., .HEPB., .HIF., .IIR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TOLL., .TRASR.","Toll receptor signaling pathway","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","activation of NF-kappaB-inducing kinase activity; aging; cellular response to cytokine stimulus; cellular response to heat; cellular response to hypoxia; cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; immune system process; innate immune response; interleukin-1-mediated signaling pathway; intracellular signal transduction; JNK cascade; lipopolysaccharide-mediated signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of NF-kappaB transcription factor activity; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of MAP kinase activity; positive regulation of molecular function; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of smooth muscle cell proliferation; positive regulation of type I interferon production; protein autophosphorylation; protein phosphorylation; regulation of cellular biosynthetic process; regulation of cytokine-mediated signaling pathway; regulation of gene expression; regulation of macromolecule biosynthetic process; regulation of response to stimulus; response to interleukin-1; response to lipopolysaccharide; signal transduction; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; type I interferon-mediated signaling pathway","ATP binding; heat shock protein binding; identical protein binding; kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endosome membrane; lipid droplet; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex","Immunology","interleukin 1 receptor associated kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=3654","3654","16179","363520",null,null,null,"P51617","Q62406","A0A0G2JYX9","A0A8I3PV99","F1RZU1","A0A1D5QFS2","GO:0005737; GO:0005829; GO:0010008; GO:0005811; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991","GO:0005524; GO:0031072; GO:0042802; GO:0016301; GO:0004704; GO:0000166; GO:0005515; GO:0046982; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0007250; GO:0007568; GO:0071345; GO:0034605; GO:0071456; GO:0071222; GO:0019221; GO:0002376; GO:0045087; GO:0070498; GO:0035556; GO:0007254; GO:0031663; GO:0002755; GO:0032088; GO:0016310; GO:0043123; GO:1904996; GO:0043406; GO:0044093; GO:0051092; GO:1901224; GO:0048661; GO:0032481; GO:0046777; GO:0006468; GO:0031326; GO:0001959; GO:0010468; GO:0010556; GO:0048583; GO:0070555; GO:0032496; GO:0007165; GO:0034134; GO:0034142; GO:0034162; GO:0002224; GO:0060337","PTHR24419:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6112|UniProtKB=P51617","P00054"]
["IRAK1 - phospho","Thr387","IRAK1","70","rb",null,2,7,4,4,4,4,"# 1144",".CCP., .CP., .CSP., .DI., .HEPB., .HIF., .IIR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TOLL., .TRASR.","Toll receptor signaling pathway","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","activation of NF-kappaB-inducing kinase activity; aging; cellular response to cytokine stimulus; cellular response to heat; cellular response to hypoxia; cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; immune system process; innate immune response; interleukin-1-mediated signaling pathway; intracellular signal transduction; JNK cascade; lipopolysaccharide-mediated signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of NF-kappaB transcription factor activity; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of MAP kinase activity; positive regulation of molecular function; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of smooth muscle cell proliferation; positive regulation of type I interferon production; protein autophosphorylation; protein phosphorylation; regulation of cellular biosynthetic process; regulation of cytokine-mediated signaling pathway; regulation of gene expression; regulation of macromolecule biosynthetic process; regulation of response to stimulus; response to interleukin-1; response to lipopolysaccharide; signal transduction; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; type I interferon-mediated signaling pathway","ATP binding; heat shock protein binding; identical protein binding; kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endosome membrane; lipid droplet; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex",null,"interleukin 1 receptor associated kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=3654","3654","16179","363520",null,null,null,"P51617","Q62406","A0A0G2JYX9","A0A8I3PV99","F1RZU1","A0A1D5QFS2","GO:0005737; GO:0005829; GO:0010008; GO:0005811; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991","GO:0005524; GO:0031072; GO:0042802; GO:0016301; GO:0004704; GO:0000166; GO:0005515; GO:0046982; GO:0042803; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0007250; GO:0007568; GO:0071345; GO:0034605; GO:0071456; GO:0071222; GO:0019221; GO:0002376; GO:0045087; GO:0070498; GO:0035556; GO:0007254; GO:0031663; GO:0002755; GO:0032088; GO:0016310; GO:0043123; GO:1904996; GO:0043406; GO:0044093; GO:0051092; GO:1901224; GO:0048661; GO:0032481; GO:0046777; GO:0006468; GO:0031326; GO:0001959; GO:0010468; GO:0010556; GO:0048583; GO:0070555; GO:0032496; GO:0007165; GO:0034134; GO:0034142; GO:0034162; GO:0002224; GO:0060337","PTHR24419:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6112|UniProtKB=P51617","P00054"]
["IRAK4",null,"IRAK4","55","rb",null,2,2,6,2,1,8,"# 1322",".CCP., .CP., .CSP., .DI., .HEPB., .IIR., .IMU., .IMUF., .IMUR., .INFM., .JNK., .MAPK., .NFKB., .OP., .OPA., .RTK., .SREME., .ST., .TOLL.","Toll receptor signaling pathway","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4","cellular response to organic substance; cytokine-mediated signaling pathway; immune system process; innate immune response; interleukin-1-mediated signaling pathway; intracellular signal transduction; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; neutrophil mediated immunity; neutrophil migration; phosphorylation; positive regulation of defense response; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of response to external stimulus; positive regulation of smooth muscle cell proliferation; protein phosphorylation; signal transduction; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway","ATP binding; interleukin-1 receptor binding; kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endosome membrane; extracellular space; nucleus; plasma membrane","Immunology","interleukin 1 receptor associated kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=51135","51135","266632","300177",null,null,"700568","Q9NWZ3","Q8R4K2","A0A8I6G1H3","A0A8I3Q059","A0A5G2QQD7","F7HHC6","GO:0005737; GO:0005829; GO:0010008; GO:0005615; GO:0005634; GO:0005886","GO:0005524; GO:0005149; GO:0016301; GO:0000287; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0071310; GO:0019221; GO:0002376; GO:0045087; GO:0070498; GO:0035556; GO:0007254; GO:0002755; GO:0002446; GO:1990266; GO:0016310; GO:0031349; GO:0043123; GO:0032103; GO:0048661; GO:0006468; GO:0007165; GO:0034162; GO:0002224","PTHR24419:SF35","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17967|UniProtKB=Q9NWZ3","P00054"]
["IRAK4 - phospho","Thr345/Ser346","IRAK4","55","rb",null,2,2,8,2.1,6,2,"# 1308",".CCP., .CP., .CSP., .DI., .HEPB., .IIR., .IMU., .IMUF., .IMUR., .INFM., .JNK., .MAPK., .NFKB., .OP., .OPA., .RTK., .SREME., .ST., .TOLL.","Toll receptor signaling pathway","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4","cellular response to organic substance; cytokine-mediated signaling pathway; immune system process; innate immune response; interleukin-1-mediated signaling pathway; intracellular signal transduction; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; neutrophil mediated immunity; neutrophil migration; phosphorylation; positive regulation of defense response; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of response to external stimulus; positive regulation of smooth muscle cell proliferation; protein phosphorylation; signal transduction; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway","ATP binding; interleukin-1 receptor binding; kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endosome membrane; extracellular space; nucleus; plasma membrane","Immunology","interleukin 1 receptor associated kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=51135","51135","266632","300177",null,null,"700568","Q9NWZ3","Q8R4K2","A0A8I6G1H3","A0A8I3Q059","A0A5G2QQD7","F7HHC6","GO:0005737; GO:0005829; GO:0010008; GO:0005615; GO:0005634; GO:0005886","GO:0005524; GO:0005149; GO:0016301; GO:0000287; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0071310; GO:0019221; GO:0002376; GO:0045087; GO:0070498; GO:0035556; GO:0007254; GO:0002755; GO:0002446; GO:1990266; GO:0016310; GO:0031349; GO:0043123; GO:0032103; GO:0048661; GO:0006468; GO:0007165; GO:0034162; GO:0002224","PTHR24419:SF35","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17967|UniProtKB=Q9NWZ3","P00054"]
["IRE1 alpha",null,"ERN1","130","rb",null,1.1000000000000001,1.1000000000000001,4,4,4,4,"# 0689",".ALZ., .APH., .APO., .CCP., .CD., .CP., .CSP., .DI., .HUNT., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR.","Alzheimer disease-presenilin pathway","SERINE/THREONINE-PROTEIN KINASE/ENDORIBONUCLEASE IRE1","apoptotic process; cellular response to glucose stimulus; cellular response to hydrogen peroxide; cellular response to unfolded protein; cellular response to vascular endothelial growth factor stimulus; endoplasmic reticulum unfolded protein response; endothelial cell proliferation; insulin metabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IRE1-mediated unfolded protein response; metabolic process; mRNA catabolic process; mRNA cleavage; mRNA cleavage involved in mRNA processing; mRNA processing; mRNA splicing, via endonucleolytic cleavage and ligation; peptidyl-serine autophosphorylation; peptidyl-serine trans-autophosphorylation; phosphorylation; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of JUN kinase activity; positive regulation of RNA splicing; positive regulation of vascular associated smooth muscle cell proliferation; protein autophosphorylation; protein phosphorylation; regulation of gene expression; regulation of macroautophagy; regulation of RNA metabolic process; response to endoplasmic reticulum stress; response to unfolded protein; RNA phosphodiester bond hydrolysis, endonucleolytic","ADP binding; ATP binding; catalytic activity; endonuclease activity; endoribonuclease activity; enzyme binding; Hsp70 protein binding; Hsp90 protein binding; hydrolase activity; identical protein binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; ribonuclease activity; transferase activity; unfolded protein binding","AIP1-IRE1 complex; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; Ire1 complex; IRE1-RACK1-PP2A complex; IRE1-TRAF2-ASK1 complex; membrane; mitochondrion; nuclear inner membrane","Translational control","endoplasmic reticulum to nucleus signaling 1","http://www.ncbi.nlm.nih.gov/gene/?term=2081","2081","78943","498013","610766",null,"717751","O75460","Q9EQY0","A0A0G2K2H4","A0A8P0NDV4",null,"A0A5F8A6W0","GO:1990597; GO:0005737; GO:0005783; GO:0005789; GO:1990332; GO:1990630; GO:1990604; GO:0016020; GO:0005739; GO:0005637","GO:0043531; GO:0005524; GO:0003824; GO:0004519; GO:0004521; GO:0019899; GO:0030544; GO:0051879; GO:0016787; GO:0042802; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005161; GO:0005515; GO:0042803; GO:0004672; GO:0106310; GO:0004674; GO:0004540; GO:0016740; GO:0051082","GO:0006915; GO:0071333; GO:0070301; GO:0034620; GO:0035924; GO:0030968; GO:0001935; GO:1901142; GO:0070059; GO:0036498; GO:0008152; GO:0006402; GO:0006379; GO:0098787; GO:0006397; GO:0070054; GO:0036289; GO:1990579; GO:0016310; GO:1900103; GO:0043507; GO:0033120; GO:1904707; GO:0046777; GO:0006468; GO:0010468; GO:0016241; GO:0051252; GO:0034976; GO:0006986; GO:0090502","PTHR13954:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3449|UniProtKB=O75460","P00004"]
["IRS-1 - phospho","Ser636/Ser639","IRS1","180","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1475",".ALZ., .AMPK., .APH., .CCKR., .CCP., .CD., .CP., .CSP., .DI., .FOXO., .INS., .INT., .MTOR., .OP., .OPA., .PI3K., .RTK., .SREME., .ST.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; PI3 kinase pathway","INSULIN RECEPTOR SUBSTRATE 1","cellular response to fatty acid; cellular response to insulin stimulus; glucose homeostasis; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; phosphatidylinositol 3-kinase signaling; positive regulation of cell population proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; response to insulin; response to peptide hormone; signal transduction","insulin receptor binding; insulin-like growth factor receptor binding; phosphatidylinositol 3-kinase binding; phosphotyrosine residue binding; protein binding; protein kinase C binding; SH2 domain binding; signaling receptor complex adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity","caveola; cytoplasm; cytosol; insulin receptor complex; intracellular membrane-bounded organelle; nucleoplasm; nucleus; plasma membrane","Metabolism","insulin receptor substrate 1","http://www.ncbi.nlm.nih.gov/gene/?term=3667","3667","16367",null,null,null,"707870","P35568","Q543V3","G3V7V7","A0A8P0TN54","I3LLF1","A0A1D5QB09","GO:0005901; GO:0005737; GO:0005829; GO:0005899; GO:0043231; GO:0005654; GO:0005634; GO:0005886","GO:0005158; GO:0005159; GO:0043548; GO:0001784; GO:0005515; GO:0005080; GO:0042169; GO:0030159; GO:0005068","GO:0071398; GO:0032869; GO:0042593; GO:0008286; GO:0048009; GO:0046627; GO:0046676; GO:0014065; GO:0008284; GO:0032000; GO:0046326; GO:0010907; GO:0045725; GO:0046628; GO:0043552; GO:0032868; GO:0043434; GO:0007165","PTHR10614:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6125|UniProtKB=P35568","P06959; P00032; P00036; P00033; P06664; P00048"]
["IRS-1 - phospho","Tyr1222","IRS1","180","rb",null,4,6,"n/a","n/a","n/a","n/a","# 1492",".ALZ., .AMPK., .APH., .CCKR., .CCP., .CD., .CP., .CSP., .DI., .FOXO., .INS., .INT., .MTOR., .OP., .OPA., .PI3K., .RTK., .SREME., .ST.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; PI3 kinase pathway","INSULIN RECEPTOR SUBSTRATE 1","cellular response to fatty acid; cellular response to insulin stimulus; glucose homeostasis; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; phosphatidylinositol 3-kinase signaling; positive regulation of cell population proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; response to insulin; response to peptide hormone; signal transduction","insulin receptor binding; insulin-like growth factor receptor binding; phosphatidylinositol 3-kinase binding; phosphotyrosine residue binding; protein binding; protein kinase C binding; SH2 domain binding; signaling receptor complex adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity","caveola; cytoplasm; cytosol; insulin receptor complex; intracellular membrane-bounded organelle; nucleoplasm; nucleus; plasma membrane","Metabolism","insulin receptor substrate 1","http://www.ncbi.nlm.nih.gov/gene/?term=3667","3667","16367",null,null,null,"707870","P35568","Q543V3","G3V7V7","A0A8P0TN54","I3LLF1","A0A1D5QB09","GO:0005901; GO:0005737; GO:0005829; GO:0005899; GO:0043231; GO:0005654; GO:0005634; GO:0005886","GO:0005158; GO:0005159; GO:0043548; GO:0001784; GO:0005515; GO:0005080; GO:0042169; GO:0030159; GO:0005068","GO:0071398; GO:0032869; GO:0042593; GO:0008286; GO:0048009; GO:0046627; GO:0046676; GO:0014065; GO:0008284; GO:0032000; GO:0046326; GO:0010907; GO:0045725; GO:0046628; GO:0043552; GO:0032868; GO:0043434; GO:0007165","PTHR10614:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6125|UniProtKB=P35568","P06959; P00032; P00036; P00033; P06664; P00048"]
["Jagged1",null,"JAG1","180","rb",null,2,4,4,4,4,4,"# 1431",".ANG., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .DRR., .IMU., .IMUR., .MIG., .NOTCH., .OP., .OT., .TCD., .TMAT., .TNF., .TRASR.","Notch signaling pathway; Angiogenesis","PROTEIN JAGGED-1","angiogenesis; animal organ morphogenesis; aorta morphogenesis; aortic valve morphogenesis; blood vessel remodeling; camera-type eye development; cardiac neural crest cell development involved in outflow tract morphogenesis; cardiac right ventricle morphogenesis; cardiac septum morphogenesis; cell communication; cell fate determination; ciliary body morphogenesis; developmental process; distal tubule development; endocardial cushion cell development; endothelial cell differentiation; hemopoiesis; inhibition of neuroepithelial cell differentiation; inner ear auditory receptor cell differentiation; inner ear development; keratinocyte differentiation; loop of Henle development; morphogenesis of an epithelial sheet; myoblast differentiation; negative regulation of cell migration; negative regulation of cell-cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of endothelial cell differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; negative regulation of stem cell differentiation; nephron development; nervous system development; neuroendocrine cell differentiation; neuron differentiation; neuronal stem cell population maintenance; Notch signaling involved in heart development; Notch signaling pathway; podocyte development; positive regulation of cardiac epithelial to mesenchymal transition; positive regulation of myeloid cell differentiation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription by RNA polymerase II; pulmonary artery morphogenesis; pulmonary valve morphogenesis; regulation of cell population proliferation; regulation of epithelial cell proliferation; regulation of reproductive process; response to muramyl dipeptide; T cell mediated immunity","calcium ion binding; growth factor activity; molecular adaptor activity; Notch binding; phospholipid binding; protein binding; structural molecule activity","adherens junction; apical part of cell; apical plasma membrane; extracellular region; membrane; plasma membrane","Development","jagged canonical Notch ligand 1","http://www.ncbi.nlm.nih.gov/gene/?term=182","182","16449",null,"485769","100156773",null,"P78504","Q9QXX0","A0A8I6ASU4","A0A8I3Q037","A0A287A671","A0A1D5R0T8","GO:0005912; GO:0045177; GO:0016324; GO:0005576; GO:0016020; GO:0005886","GO:0005509; GO:0008083; GO:0060090; GO:0005112; GO:0005543; GO:0005515; GO:0005198","GO:0001525; GO:0009887; GO:0035909; GO:0003180; GO:0001974; GO:0043010; GO:0061309; GO:0003215; GO:0060411; GO:0007154; GO:0001709; GO:0061073; GO:0032502; GO:0072017; GO:0061444; GO:0045446; GO:0030097; GO:0002085; GO:0042491; GO:0048839; GO:0030216; GO:0072070; GO:0002011; GO:0045445; GO:0030336; GO:0022408; GO:0001953; GO:0045602; GO:0045599; GO:0045665; GO:2000737; GO:0072006; GO:0007399; GO:0061101; GO:0030182; GO:0097150; GO:0061314; GO:0007219; GO:0072015; GO:0062043; GO:0045639; GO:0045747; GO:0045669; GO:0045944; GO:0061156; GO:0003184; GO:0042127; GO:0050678; GO:2000241; GO:0032495; GO:0002456","PTHR24044:SF448","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6188|UniProtKB=P78504","P00045; P00005"]
["Jagged2",null,"JAG2","150","rb",null,2,7,7,4,4,4,"# 1377",".ANG., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .IMUF., .NOTCH., .OP., .TCD., .TCR., .TMAT.","Notch signaling pathway; Angiogenesis","PROTEIN JAGGED-2","auditory receptor cell fate commitment; cell communication; cell differentiation; developmental process; epithelial cell apoptotic process involved in palatal shelf morphogenesis; gamma-delta T cell differentiation; in utero embryonic development; morphogenesis of embryonic epithelium; Notch signaling pathway; odontogenesis of dentin-containing tooth; positive regulation of Notch signaling pathway; regulation of cell adhesion; regulation of cell population proliferation; respiratory system process; skeletal system development; spermatogenesis; T cell differentiation; thymic T cell selection","calcium ion binding; growth factor activity; Notch binding; protein binding","membrane; plasma membrane","Development","jagged canonical Notch ligand 2","http://www.ncbi.nlm.nih.gov/gene/?term=3714","3714","16450",null,null,null,null,"Q9Y219","Q9QYE5","A0A8I5ZUZ8","A0A8P0NJU2","A0A8W4FMF4","A0A5F7ZKL4","GO:0016020; GO:0005886","GO:0005509; GO:0008083; GO:0005112; GO:0005515","GO:0009912; GO:0007154; GO:0030154; GO:0032502; GO:1990134; GO:0042492; GO:0001701; GO:0016331; GO:0007219; GO:0042475; GO:0045747; GO:0030155; GO:0042127; GO:0003016; GO:0001501; GO:0007283; GO:0030217; GO:0045061","PTHR24044:SF421","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6189|UniProtKB=Q9Y219","P00045; P00005"]
["Jak1",null,"JAK1","130","rb",null,2.1,1.1000000000000001,4,4,4,4,"# 2821",".ANG., .CANCER., .CANPTHW., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DRAS., .EGFR., .HEPB., .IMUF., .IMUR., .INFG., .INFM., .OP., .OPA., .PAC., .PDGF., .PI3K., .RTK., .ST., .STAT., .TCD., .TMAT., .VIR.","Interferon-gamma signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Angiogenesis","TYROSINE-PROTEIN KINASE JAK1","cell differentiation; cellular response to virus; cytokine-mediated signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; interleukin-2-mediated signaling pathway; interleukin-6-mediated signaling pathway; intracellular signal transduction; phosphorylation; positive regulation of homotypic cell-cell adhesion; positive regulation of sprouting angiogenesis; protein localization to cell-cell junction; protein phosphorylation; receptor signaling pathway via JAK-STAT; regulation of cell adhesion; regulation of multicellular organismal process; response to antibiotic; type I interferon-mediated signaling pathway; type II interferon-mediated signaling pathway; type III interferon-mediated signaling pathway; tyrosine phosphorylation of STAT protein","ATP binding; CCR5 chemokine receptor binding; cytokine receptor binding; growth hormone receptor binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding","cytoplasm; cytoskeleton; cytosol; endomembrane system; endosome; focal adhesion; membrane; nucleus","Jak/Stat signaling","Janus kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=3716","3716","16451",null,null,null,null,"P23458","B1ASP2","A0A8I5ZU24","A0A8I3MQH9",null,"A0A5F7ZH35","GO:0005737; GO:0005856; GO:0005829; GO:0012505; GO:0005768; GO:0005925; GO:0016020; GO:0005634","GO:0005524; GO:0031730; GO:0005126; GO:0005131; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0016740; GO:0031625","GO:0030154; GO:0098586; GO:0019221; GO:0060397; GO:0038110; GO:0070102; GO:0035556; GO:0016310; GO:0034112; GO:1903672; GO:0150105; GO:0006468; GO:0007259; GO:0030155; GO:0051239; GO:0046677; GO:0060337; GO:0060333; GO:0038196; GO:0007260","PTHR45807:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6190|UniProtKB=P23458","P00035; P00047; P00038; P00005"]
["Jak1 - phospho","Tyr1022/Tyr1023","JAK1","130","rb",null,2,2,6,6,4,4,"# 3195",".ANG., .CANCER., .CANPTHW., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DRAS., .EGFR., .HEPB., .IMUF., .IMUR., .INFG., .INFM., .OP., .OPA., .PAC., .PDGF., .PI3K., .RTK., .ST., .STAT., .TCD., .TMAT., .VIR.","Interferon-gamma signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Angiogenesis","TYROSINE-PROTEIN KINASE JAK1","cell differentiation; cellular response to virus; cytokine-mediated signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; interleukin-2-mediated signaling pathway; interleukin-6-mediated signaling pathway; intracellular signal transduction; phosphorylation; positive regulation of homotypic cell-cell adhesion; positive regulation of sprouting angiogenesis; protein localization to cell-cell junction; protein phosphorylation; receptor signaling pathway via JAK-STAT; regulation of cell adhesion; regulation of multicellular organismal process; response to antibiotic; type I interferon-mediated signaling pathway; type II interferon-mediated signaling pathway; type III interferon-mediated signaling pathway; tyrosine phosphorylation of STAT protein","ATP binding; CCR5 chemokine receptor binding; cytokine receptor binding; growth hormone receptor binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding","cytoplasm; cytoskeleton; cytosol; endomembrane system; endosome; focal adhesion; membrane; nucleus","Jak/Stat signaling","Janus kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=3716","3716","16451",null,null,null,null,"P23458","B1ASP2","A0A8I5ZU24","A0A8I3MQH9",null,"A0A5F7ZH35","GO:0005737; GO:0005856; GO:0005829; GO:0012505; GO:0005768; GO:0005925; GO:0016020; GO:0005634","GO:0005524; GO:0031730; GO:0005126; GO:0005131; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0004713; GO:0016740; GO:0031625","GO:0030154; GO:0098586; GO:0019221; GO:0060397; GO:0038110; GO:0070102; GO:0035556; GO:0016310; GO:0034112; GO:1903672; GO:0150105; GO:0006468; GO:0007259; GO:0030155; GO:0051239; GO:0046677; GO:0060337; GO:0060333; GO:0038196; GO:0007260","PTHR45807:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6190|UniProtKB=P23458","P00035; P00047; P00038; P00005"]
["Jak2",null,"JAK2","125","rb",null,1,2,"n/a","n/a","n/a","n/a","# 2337",".APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRAS., .EGFR., .GPCR., .GPROT., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PLAT., .RTK., .SREME., .ST., .STAT., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .VIR.","CCKR signaling map; Interferon-gamma signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; PI3 kinase pathway","TYROSINE-PROTEIN KINASE JAK2","actin filament polymerization; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; activation of Janus kinase activity; adaptive immune response; apoptotic process; axon regeneration; cell differentiation; cellular response to dexamethasone stimulus; cellular response to interleukin-3; cellular response to lipopolysaccharide; cellular response to virus; chromatin organization; collagen-activated signaling pathway; cytokine-mediated signaling pathway; enzyme-linked receptor protein signaling pathway; erythrocyte differentiation; extrinsic apoptotic signaling pathway; G protein-coupled receptor signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; growth hormone receptor signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; histone modification; hormone-mediated signaling pathway; immune response; immune system process; innate immune response; interleukin-12-mediated signaling pathway; interleukin-35-mediated signaling pathway; interleukin-6-mediated signaling pathway; intracellular signal transduction; intrinsic apoptotic signaling pathway in response to oxidative stress; mammary gland epithelium development; mesoderm development; microglial cell activation; mineralocorticoid receptor signaling pathway; modulation of chemical synaptic transmission; myeloid cell differentiation; negative regulation of apoptotic process; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell death; negative regulation of cell population proliferation; negative regulation of cell-cell adhesion; negative regulation of DNA binding; negative regulation of heart contraction; negative regulation of neuron apoptotic process; peptidyl-tyrosine phosphorylation; phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cell activation; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell-substrate adhesion; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA binding; positive regulation of DNA-binding transcription factor activity; positive regulation of epithelial cell apoptotic process; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of growth hormone receptor signaling pathway; positive regulation of inflammatory response; positive regulation of insulin secretion; positive regulation of interleukin-1 beta production; positive regulation of interleukin-17 production; positive regulation of leukocyte proliferation; positive regulation of MAPK cascade; positive regulation of MHC class II biosynthetic process; positive regulation of natural killer cell proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of NK T cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phosphoprotein phosphatase activity; positive regulation of platelet activation; positive regulation of platelet aggregation; positive regulation of protein import into nucleus; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of signaling receptor activity; positive regulation of SMAD protein signal transduction; positive regulation of T cell proliferation; positive regulation of T-helper 17 type immune response; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of type II interferon production; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular associated smooth muscle cell proliferation; post-embryonic hemopoiesis; post-translational protein modification; programmed cell death induced by symbiont; protein autophosphorylation; protein phosphorylation; receptor signaling pathway via JAK-STAT; regulation of apoptotic process; regulation of cell adhesion; regulation of inflammatory response; regulation of multicellular organismal process; regulation of nitric oxide biosynthetic process; regulation of postsynapse to nucleus signaling pathway; regulation of receptor signaling pathway via JAK-STAT; response to amine; response to antibiotic; response to hydroperoxide; response to interleukin-12; response to lipopolysaccharide; response to organic cyclic compound; response to oxidative stress; response to tumor necrosis factor; signal transduction; transcription by RNA polymerase II; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; tyrosine phosphorylation of STAT protein","acetylcholine receptor binding; ATP binding; cytokine receptor binding; growth hormone receptor binding; heme binding; histone binding; histone H3Y41 kinase activity; identical protein binding; insulin receptor substrate binding; interleukin-12 receptor binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; peptide hormone receptor binding; phosphatidylinositol 3-kinase binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; SH2 domain binding; signaling receptor binding; transferase activity; type 1 angiotensin receptor binding","caveola; cytoplasm; cytoskeleton; cytosol; endomembrane system; endosome lumen; euchromatin; focal adhesion; glutamatergic synapse; granulocyte macrophage colony-stimulating factor receptor complex; interleukin-12 receptor complex; interleukin-23 receptor complex; membrane; membrane raft; nucleolus; nucleoplasm; nucleus; plasma membrane; postsynapse","Jak/Stat signaling","Janus kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=3717","3717","16452","24514",null,"397201","694184","O60674","Q62120","Q62689","A0A8P0P7F1","O19064","A0A5F8ATC5","GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0012505; GO:0031904; GO:0000791; GO:0005925; GO:0098978; GO:0030526; GO:0042022; GO:0072536; GO:0016020; GO:0045121; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0098794","GO:0033130; GO:0005524; GO:0005126; GO:0005131; GO:0020037; GO:0042393; GO:0035401; GO:0042802; GO:0043560; GO:0005143; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0051428; GO:0043548; GO:0005515; GO:0008022; GO:0004672; GO:0019901; GO:0004713; GO:0042169; GO:0005102; GO:0016740; GO:0031702","GO:0030041; GO:0006919; GO:0097296; GO:0042976; GO:0002250; GO:0006915; GO:0031103; GO:0030154; GO:0071549; GO:0036016; GO:0071222; GO:0098586; GO:0006325; GO:0038065; GO:0019221; GO:0007167; GO:0030218; GO:0097191; GO:0007186; GO:0038157; GO:0060396; GO:0060397; GO:0016570; GO:0009755; GO:0006955; GO:0002376; GO:0045087; GO:0035722; GO:0070757; GO:0070102; GO:0035556; GO:0008631; GO:0061180; GO:0007498; GO:0001774; GO:0031959; GO:0050804; GO:0030099; GO:0043066; GO:0010667; GO:0060548; GO:0008285; GO:0022408; GO:0043392; GO:0045822; GO:0043524; GO:0018108; GO:0016310; GO:0048008; GO:0043065; GO:2001235; GO:0050867; GO:0045597; GO:0030335; GO:0008284; GO:0010811; GO:0120162; GO:0007204; GO:0043388; GO:0051091; GO:1904037; GO:1902728; GO:0060399; GO:0050729; GO:0032024; GO:0032731; GO:0032740; GO:0070665; GO:0043410; GO:0045348; GO:0032819; GO:0045429; GO:0051770; GO:0051142; GO:0050731; GO:0014068; GO:0032516; GO:0010572; GO:1901731; GO:0042307; GO:0046427; GO:2000273; GO:0060391; GO:0042102; GO:2000318; GO:0045944; GO:0032760; GO:0032729; GO:0042531; GO:1904707; GO:0035166; GO:0043687; GO:0034050; GO:0046777; GO:0006468; GO:0007259; GO:0042981; GO:0030155; GO:0050727; GO:0051239; GO:0045428; GO:1905539; GO:0046425; GO:0014075; GO:0046677; GO:0033194; GO:0070671; GO:0032496; GO:0014070; GO:0006979; GO:0034612; GO:0007165; GO:0006366; GO:0033209; GO:0060333; GO:0007260","PTHR45807:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6192|UniProtKB=O60674","P06959; P00035; P00047; P00038; P00031; P00048"]
["Jak2",null,"JAK2","125","rb",null,2,1,1.1000000000000001,1.1000000000000001,1.1000000000000001,1.1000000000000001,"TK # 073",".APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .GPCR., .GPROT., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PLAT., .RTK., .SREME., .ST., .STAT., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .VIR.","CCKR signaling map; Interferon-gamma signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; PI3 kinase pathway","TYROSINE-PROTEIN KINASE JAK2","actin filament polymerization; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; activation of Janus kinase activity; adaptive immune response; apoptotic process; axon regeneration; cell differentiation; cellular response to dexamethasone stimulus; cellular response to interleukin-3; cellular response to lipopolysaccharide; cellular response to virus; chromatin organization; collagen-activated signaling pathway; cytokine-mediated signaling pathway; enzyme-linked receptor protein signaling pathway; erythrocyte differentiation; extrinsic apoptotic signaling pathway; G protein-coupled receptor signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; growth hormone receptor signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; histone modification; hormone-mediated signaling pathway; immune response; immune system process; innate immune response; interleukin-12-mediated signaling pathway; interleukin-35-mediated signaling pathway; interleukin-6-mediated signaling pathway; intracellular signal transduction; intrinsic apoptotic signaling pathway in response to oxidative stress; mammary gland epithelium development; mesoderm development; microglial cell activation; mineralocorticoid receptor signaling pathway; modulation of chemical synaptic transmission; myeloid cell differentiation; negative regulation of apoptotic process; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell death; negative regulation of cell population proliferation; negative regulation of cell-cell adhesion; negative regulation of DNA binding; negative regulation of heart contraction; negative regulation of neuron apoptotic process; peptidyl-tyrosine phosphorylation; phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cell activation; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell-substrate adhesion; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA binding; positive regulation of DNA-binding transcription factor activity; positive regulation of epithelial cell apoptotic process; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of growth hormone receptor signaling pathway; positive regulation of inflammatory response; positive regulation of insulin secretion; positive regulation of interleukin-1 beta production; positive regulation of interleukin-17 production; positive regulation of leukocyte proliferation; positive regulation of MAPK cascade; positive regulation of MHC class II biosynthetic process; positive regulation of natural killer cell proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of NK T cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phosphoprotein phosphatase activity; positive regulation of platelet activation; positive regulation of platelet aggregation; positive regulation of protein import into nucleus; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of signaling receptor activity; positive regulation of SMAD protein signal transduction; positive regulation of T cell proliferation; positive regulation of T-helper 17 type immune response; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of type II interferon production; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular associated smooth muscle cell proliferation; post-embryonic hemopoiesis; post-translational protein modification; programmed cell death induced by symbiont; protein autophosphorylation; protein phosphorylation; receptor signaling pathway via JAK-STAT; regulation of apoptotic process; regulation of cell adhesion; regulation of inflammatory response; regulation of multicellular organismal process; regulation of nitric oxide biosynthetic process; regulation of postsynapse to nucleus signaling pathway; regulation of receptor signaling pathway via JAK-STAT; response to amine; response to antibiotic; response to hydroperoxide; response to interleukin-12; response to lipopolysaccharide; response to organic cyclic compound; response to oxidative stress; response to tumor necrosis factor; signal transduction; transcription by RNA polymerase II; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; tyrosine phosphorylation of STAT protein","acetylcholine receptor binding; ATP binding; cytokine receptor binding; growth hormone receptor binding; heme binding; histone binding; histone H3Y41 kinase activity; identical protein binding; insulin receptor substrate binding; interleukin-12 receptor binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; peptide hormone receptor binding; phosphatidylinositol 3-kinase binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; SH2 domain binding; signaling receptor binding; transferase activity; type 1 angiotensin receptor binding","caveola; cytoplasm; cytoskeleton; cytosol; endomembrane system; endosome lumen; euchromatin; focal adhesion; glutamatergic synapse; granulocyte macrophage colony-stimulating factor receptor complex; interleukin-12 receptor complex; interleukin-23 receptor complex; membrane; membrane raft; nucleolus; nucleoplasm; nucleus; plasma membrane; postsynapse","Jak/Stat signaling","Janus kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=3717","3717","16452","24514",null,"397201","694184","O60674","Q62120","Q62689","A0A8P0P7F1","O19064","A0A5F8ATC5","GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0012505; GO:0031904; GO:0000791; GO:0005925; GO:0098978; GO:0030526; GO:0042022; GO:0072536; GO:0016020; GO:0045121; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0098794","GO:0033130; GO:0005524; GO:0005126; GO:0005131; GO:0020037; GO:0042393; GO:0035401; GO:0042802; GO:0043560; GO:0005143; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0051428; GO:0043548; GO:0005515; GO:0008022; GO:0004672; GO:0019901; GO:0004713; GO:0042169; GO:0005102; GO:0016740; GO:0031702","GO:0030041; GO:0006919; GO:0097296; GO:0042976; GO:0002250; GO:0006915; GO:0031103; GO:0030154; GO:0071549; GO:0036016; GO:0071222; GO:0098586; GO:0006325; GO:0038065; GO:0019221; GO:0007167; GO:0030218; GO:0097191; GO:0007186; GO:0038157; GO:0060396; GO:0060397; GO:0016570; GO:0009755; GO:0006955; GO:0002376; GO:0045087; GO:0035722; GO:0070757; GO:0070102; GO:0035556; GO:0008631; GO:0061180; GO:0007498; GO:0001774; GO:0031959; GO:0050804; GO:0030099; GO:0043066; GO:0010667; GO:0060548; GO:0008285; GO:0022408; GO:0043392; GO:0045822; GO:0043524; GO:0018108; GO:0016310; GO:0048008; GO:0043065; GO:2001235; GO:0050867; GO:0045597; GO:0030335; GO:0008284; GO:0010811; GO:0120162; GO:0007204; GO:0043388; GO:0051091; GO:1904037; GO:1902728; GO:0060399; GO:0050729; GO:0032024; GO:0032731; GO:0032740; GO:0070665; GO:0043410; GO:0045348; GO:0032819; GO:0045429; GO:0051770; GO:0051142; GO:0050731; GO:0014068; GO:0032516; GO:0010572; GO:1901731; GO:0042307; GO:0046427; GO:2000273; GO:0060391; GO:0042102; GO:2000318; GO:0045944; GO:0032760; GO:0032729; GO:0042531; GO:1904707; GO:0035166; GO:0043687; GO:0034050; GO:0046777; GO:0006468; GO:0007259; GO:0042981; GO:0030155; GO:0050727; GO:0051239; GO:0045428; GO:1905539; GO:0046425; GO:0014075; GO:0046677; GO:0033194; GO:0070671; GO:0032496; GO:0014070; GO:0006979; GO:0034612; GO:0007165; GO:0006366; GO:0033209; GO:0060333; GO:0007260","PTHR45807:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6192|UniProtKB=O60674","P06959; P00035; P00047; P00038; P00031; P00048"]
["Jak2 - phospho","Tyr1007/Tyr1008","JAK2","125","rb",null,2,2,2,8,4,4,"# 2475",".APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRAS., .EGFR., .GPCR., .GPROT., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PLAT., .RTK., .SREME., .ST., .STAT., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .VIR.","CCKR signaling map; Interferon-gamma signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; PI3 kinase pathway","TYROSINE-PROTEIN KINASE JAK2","actin filament polymerization; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; activation of Janus kinase activity; adaptive immune response; apoptotic process; axon regeneration; cell differentiation; cellular response to dexamethasone stimulus; cellular response to interleukin-3; cellular response to lipopolysaccharide; cellular response to virus; chromatin organization; collagen-activated signaling pathway; cytokine-mediated signaling pathway; enzyme-linked receptor protein signaling pathway; erythrocyte differentiation; extrinsic apoptotic signaling pathway; G protein-coupled receptor signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; growth hormone receptor signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; histone modification; hormone-mediated signaling pathway; immune response; immune system process; innate immune response; interleukin-12-mediated signaling pathway; interleukin-35-mediated signaling pathway; interleukin-6-mediated signaling pathway; intracellular signal transduction; intrinsic apoptotic signaling pathway in response to oxidative stress; mammary gland epithelium development; mesoderm development; microglial cell activation; mineralocorticoid receptor signaling pathway; modulation of chemical synaptic transmission; myeloid cell differentiation; negative regulation of apoptotic process; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell death; negative regulation of cell population proliferation; negative regulation of cell-cell adhesion; negative regulation of DNA binding; negative regulation of heart contraction; negative regulation of neuron apoptotic process; peptidyl-tyrosine phosphorylation; phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cell activation; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell-substrate adhesion; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA binding; positive regulation of DNA-binding transcription factor activity; positive regulation of epithelial cell apoptotic process; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of growth hormone receptor signaling pathway; positive regulation of inflammatory response; positive regulation of insulin secretion; positive regulation of interleukin-1 beta production; positive regulation of interleukin-17 production; positive regulation of leukocyte proliferation; positive regulation of MAPK cascade; positive regulation of MHC class II biosynthetic process; positive regulation of natural killer cell proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of NK T cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phosphoprotein phosphatase activity; positive regulation of platelet activation; positive regulation of platelet aggregation; positive regulation of protein import into nucleus; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of signaling receptor activity; positive regulation of SMAD protein signal transduction; positive regulation of T cell proliferation; positive regulation of T-helper 17 type immune response; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of type II interferon production; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular associated smooth muscle cell proliferation; post-embryonic hemopoiesis; post-translational protein modification; programmed cell death induced by symbiont; protein autophosphorylation; protein phosphorylation; receptor signaling pathway via JAK-STAT; regulation of apoptotic process; regulation of cell adhesion; regulation of inflammatory response; regulation of multicellular organismal process; regulation of nitric oxide biosynthetic process; regulation of postsynapse to nucleus signaling pathway; regulation of receptor signaling pathway via JAK-STAT; response to amine; response to antibiotic; response to hydroperoxide; response to interleukin-12; response to lipopolysaccharide; response to organic cyclic compound; response to oxidative stress; response to tumor necrosis factor; signal transduction; transcription by RNA polymerase II; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; tyrosine phosphorylation of STAT protein","acetylcholine receptor binding; ATP binding; cytokine receptor binding; growth hormone receptor binding; heme binding; histone binding; histone H3Y41 kinase activity; identical protein binding; insulin receptor substrate binding; interleukin-12 receptor binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; peptide hormone receptor binding; phosphatidylinositol 3-kinase binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; SH2 domain binding; signaling receptor binding; transferase activity; type 1 angiotensin receptor binding","caveola; cytoplasm; cytoskeleton; cytosol; endomembrane system; endosome lumen; euchromatin; focal adhesion; glutamatergic synapse; granulocyte macrophage colony-stimulating factor receptor complex; interleukin-12 receptor complex; interleukin-23 receptor complex; membrane; membrane raft; nucleolus; nucleoplasm; nucleus; plasma membrane; postsynapse","Jak/Stat signaling","Janus kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=3717","3717","16452","24514",null,"397201","694184","O60674","Q62120","Q62689","A0A8P0P7F1","O19064","A0A5F8ATC5","GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0012505; GO:0031904; GO:0000791; GO:0005925; GO:0098978; GO:0030526; GO:0042022; GO:0072536; GO:0016020; GO:0045121; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0098794","GO:0033130; GO:0005524; GO:0005126; GO:0005131; GO:0020037; GO:0042393; GO:0035401; GO:0042802; GO:0043560; GO:0005143; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0051428; GO:0043548; GO:0005515; GO:0008022; GO:0004672; GO:0019901; GO:0004713; GO:0042169; GO:0005102; GO:0016740; GO:0031702","GO:0030041; GO:0006919; GO:0097296; GO:0042976; GO:0002250; GO:0006915; GO:0031103; GO:0030154; GO:0071549; GO:0036016; GO:0071222; GO:0098586; GO:0006325; GO:0038065; GO:0019221; GO:0007167; GO:0030218; GO:0097191; GO:0007186; GO:0038157; GO:0060396; GO:0060397; GO:0016570; GO:0009755; GO:0006955; GO:0002376; GO:0045087; GO:0035722; GO:0070757; GO:0070102; GO:0035556; GO:0008631; GO:0061180; GO:0007498; GO:0001774; GO:0031959; GO:0050804; GO:0030099; GO:0043066; GO:0010667; GO:0060548; GO:0008285; GO:0022408; GO:0043392; GO:0045822; GO:0043524; GO:0018108; GO:0016310; GO:0048008; GO:0043065; GO:2001235; GO:0050867; GO:0045597; GO:0030335; GO:0008284; GO:0010811; GO:0120162; GO:0007204; GO:0043388; GO:0051091; GO:1904037; GO:1902728; GO:0060399; GO:0050729; GO:0032024; GO:0032731; GO:0032740; GO:0070665; GO:0043410; GO:0045348; GO:0032819; GO:0045429; GO:0051770; GO:0051142; GO:0050731; GO:0014068; GO:0032516; GO:0010572; GO:1901731; GO:0042307; GO:0046427; GO:2000273; GO:0060391; GO:0042102; GO:2000318; GO:0045944; GO:0032760; GO:0032729; GO:0042531; GO:1904707; GO:0035166; GO:0043687; GO:0034050; GO:0046777; GO:0006468; GO:0007259; GO:0042981; GO:0030155; GO:0050727; GO:0051239; GO:0045428; GO:1905539; GO:0046425; GO:0014075; GO:0046677; GO:0033194; GO:0070671; GO:0032496; GO:0014070; GO:0006979; GO:0034612; GO:0007165; GO:0006366; GO:0033209; GO:0060333; GO:0007260","PTHR45807:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6192|UniProtKB=O60674","P06959; P00035; P00047; P00038; P00031; P00048"]
["Janusin",null,"TNR","180, 160","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0518",".CCP., .CP., .CSP., .MIG., .OP., .OT., .PI3K., .RTK.",null,"TENASCIN-R","associative learning; axon extension; axon extension involved in regeneration; axon guidance; cell adhesion; extracellular matrix organization; locomotory exploration behavior; long-term synaptic potentiation; modulation of chemical synaptic transmission; negative regulation of axon extension; negative regulation of axon extension involved in regeneration; negative regulation of cell-cell adhesion; negative regulation of neuron projection development; negative regulation of synaptic transmission; neuroblast migration; neuromuscular process controlling balance; neuron cell-cell adhesion; positive regulation of synaptic transmission, glutamatergic; positive regulation of transmission of nerve impulse; regulation of cell adhesion; regulation of cell differentiation; regulation of cell migration; synapse organization; synaptic transmission, glutamatergic; telencephalon cell migration","signaling receptor binding","cell surface; collagen-containing extracellular matrix; extracellular matrix; extracellular region; extracellular space; glutamatergic synapse; membrane raft; perineuronal net; Schaffer collateral - CA1 synapse; tenascin complex","Extracellular matrix","tenascin R","http://www.ncbi.nlm.nih.gov/gene/?term=7143","7143","21960",null,null,"100520686",null,"Q92752","Q8BYI9","A0A8I5ZP32","A0A8I3N7Q8","A0A481CFE3","F6QQZ0","GO:0009986; GO:0062023; GO:0031012; GO:0005576; GO:0005615; GO:0098978; GO:0045121; GO:0072534; GO:0098685; GO:0090733","GO:0005102","GO:0008306; GO:0048675; GO:0048677; GO:0007411; GO:0007155; GO:0030198; GO:0035641; GO:0060291; GO:0050804; GO:0030517; GO:0048692; GO:0022408; GO:0010977; GO:0050805; GO:0097402; GO:0050885; GO:0007158; GO:0051968; GO:0051971; GO:0030155; GO:0045595; GO:0030334; GO:0050808; GO:0035249; GO:0022029","PTHR19143:SF254","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11953|UniProtKB=Q92752"]
["JARID1A (Histone3 lysin4-demethylase, KDM5A)",null,"KDM5A","200","rb",null,2.1,4,4,4,4,7,"# 1037",".OP., .OT., .TRASR.",null,"LYSINE-SPECIFIC DEMETHYLASE 5A","chromatin organization; chromatin remodeling; circadian regulation of gene expression; facultative heterochromatin formation; histone H3-K4 demethylation; histone lysine demethylation; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; regulation of DNA-binding transcription factor activity; rhythmic process","chromatin binding; chromatin DNA binding; dioxygenase activity; DNA binding; enzyme inhibitor activity; histone binding; histone demethylase activity; histone H3K4 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; metal ion binding; methylated histone binding; oxidoreductase activity; protein binding; transcription cis-regulatory region binding; transcription coactivator activity; zinc ion binding","nucleolus; nucleoplasm; nucleus; protein-DNA complex","Chromatin regulation / epigenetics","lysine demethylase 5A","http://www.ncbi.nlm.nih.gov/gene/?term=5927","5927","214899",null,null,null,null,"P29375","Q3UXZ9","A0A096MJZ8","A0A8I3PT80","A0A287B933","A0A1D5QFI0","GO:0005730; GO:0005654; GO:0005634; GO:0032993","GO:0003682; GO:0031490; GO:0051213; GO:0003677; GO:0004857; GO:0042393; GO:0032452; GO:0032453; GO:0034647; GO:0046872; GO:0035064; GO:0016491; GO:0005515; GO:0000976; GO:0003713; GO:0008270","GO:0006325; GO:0006338; GO:0032922; GO:0140718; GO:0034720; GO:0070076; GO:0000122; GO:0045893; GO:0051090; GO:0048511","PTHR10694:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9886|UniProtKB=P29375"]
["JNK/SAPK",null,"MAPK8","54, 46","rb",null,2,1,1,1,1,1,"# 1319",".ALZ., .ANG., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CRC., .CSP., .DEV., .DI., .EGFR., .FAS., .FGFR., .FOXO., .GPCR., .HEPB., .HUNT., .IMUF., .INFG., .INS., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 8","cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to oxidative stress; cellular response to reactive oxygen species; cellular senescence; Fc-epsilon receptor signaling pathway; intracellular signal transduction; JNK cascade; JUN phosphorylation; negative regulation of apoptotic process; negative regulation of protein binding; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of cell killing; positive regulation of cyclase activity; positive regulation of deacetylase activity; positive regulation of gene expression; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of protein metabolic process; protein phosphorylation; regulation of circadian rhythm; regulation of DNA replication origin binding; regulation of DNA-binding transcription factor activity; regulation of macroautophagy; regulation of protein localization; response to mechanical stimulus; response to oxidative stress; response to UV; rhythmic process; signal transduction; stress-activated MAPK cascade","ATP binding; enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; transferase activity","axon; basal dendrite; cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus; synapse","MAPK signaling","mitogen-activated protein kinase 8","http://www.ncbi.nlm.nih.gov/gene/?term=5599","5599","26419",null,null,null,"711115","P45983","Q91Y86","A0A0G2KA63","A0A8I3PEK4",null,"F6ZKB3","GO:0030424; GO:0097441; GO:0005737; GO:0005829; GO:0043231; GO:0005739; GO:0005654; GO:0005634; GO:0045202","GO:0005524; GO:0019899; GO:0042826; GO:0035033; GO:0004705; GO:0016301; GO:0004707; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0120283; GO:0016740","GO:0034198; GO:0071276; GO:0071222; GO:0071260; GO:0034599; GO:0034614; GO:0090398; GO:0038095; GO:0035556; GO:0007254; GO:0007258; GO:0043066; GO:0032091; GO:0018105; GO:0018107; GO:0016310; GO:0043065; GO:0031343; GO:0031281; GO:0090045; GO:0010628; GO:1900227; GO:1900740; GO:0051247; GO:0006468; GO:0042752; GO:1902595; GO:0051090; GO:0016241; GO:0032880; GO:0009612; GO:0006979; GO:0009411; GO:0048511; GO:0007165; GO:0051403","PTHR24055:SF222","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6881|UniProtKB=P45983","P06959; P00053; P00052; P00010; P06664; P00021; P04393; P00035; P00034; P00047; P00005; P00054; P00049; P00046; P00018; P00003; P00020; P00006"]
["JNK/SAPK - phospho","Thr183/Tyr185","MAPK8","54, 46","ms",null,1,2,2.1,1.1000000000000001,6,4,"# 1908",".ALZ., .ANG., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CRC., .CSP., .DEV., .DI., .EGFR., .FAS., .FGFR., .FOXO., .GPCR., .HEPB., .HUNT., .IMUF., .INFG., .INS., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 8","cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to oxidative stress; cellular response to reactive oxygen species; cellular senescence; Fc-epsilon receptor signaling pathway; intracellular signal transduction; JNK cascade; JUN phosphorylation; negative regulation of apoptotic process; negative regulation of protein binding; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of cell killing; positive regulation of cyclase activity; positive regulation of deacetylase activity; positive regulation of gene expression; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of protein metabolic process; protein phosphorylation; regulation of circadian rhythm; regulation of DNA replication origin binding; regulation of DNA-binding transcription factor activity; regulation of macroautophagy; regulation of protein localization; response to mechanical stimulus; response to oxidative stress; response to UV; rhythmic process; signal transduction; stress-activated MAPK cascade","ATP binding; enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; transferase activity","axon; basal dendrite; cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus; synapse","MAPK signaling","mitogen-activated protein kinase 8","http://www.ncbi.nlm.nih.gov/gene/?term=5599","5599","26419",null,null,null,"711115","P45983","Q91Y86","A0A0G2KA63","A0A8I3PEK4",null,"F6ZKB3","GO:0030424; GO:0097441; GO:0005737; GO:0005829; GO:0043231; GO:0005739; GO:0005654; GO:0005634; GO:0045202","GO:0005524; GO:0019899; GO:0042826; GO:0035033; GO:0004705; GO:0016301; GO:0004707; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0120283; GO:0016740","GO:0034198; GO:0071276; GO:0071222; GO:0071260; GO:0034599; GO:0034614; GO:0090398; GO:0038095; GO:0035556; GO:0007254; GO:0007258; GO:0043066; GO:0032091; GO:0018105; GO:0018107; GO:0016310; GO:0043065; GO:0031343; GO:0031281; GO:0090045; GO:0010628; GO:1900227; GO:1900740; GO:0051247; GO:0006468; GO:0042752; GO:1902595; GO:0051090; GO:0016241; GO:0032880; GO:0009612; GO:0006979; GO:0009411; GO:0048511; GO:0007165; GO:0051403","PTHR24055:SF222","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6881|UniProtKB=P45983","P06959; P00053; P00052; P00010; P06664; P00021; P04393; P00035; P00034; P00047; P00005; P00054; P00049; P00046; P00018; P00003; P00020; P00006"]
["JNK/SAPK 1/2/3 - phospho","Thr183/Tyr185","MAPK8","54, 46","ms",null,7,4,"n/a","n/a","n/a","n/a","# 0898",".ALZ., .ANG., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CRC., .CSP., .DEV., .DI., .EGFR., .FAS., .FGFR., .FOXO., .GPCR., .HEPB., .HUNT., .IMUF., .INFG., .INS., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 8","cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to oxidative stress; cellular response to reactive oxygen species; cellular senescence; Fc-epsilon receptor signaling pathway; intracellular signal transduction; JNK cascade; JUN phosphorylation; negative regulation of apoptotic process; negative regulation of protein binding; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of cell killing; positive regulation of cyclase activity; positive regulation of deacetylase activity; positive regulation of gene expression; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of protein metabolic process; protein phosphorylation; regulation of circadian rhythm; regulation of DNA replication origin binding; regulation of DNA-binding transcription factor activity; regulation of macroautophagy; regulation of protein localization; response to mechanical stimulus; response to oxidative stress; response to UV; rhythmic process; signal transduction; stress-activated MAPK cascade","ATP binding; enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; transferase activity","axon; basal dendrite; cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus; synapse","MAPK signaling","mitogen-activated protein kinase 8","http://www.ncbi.nlm.nih.gov/gene/?term=5599","5599","26419",null,null,null,"711115","P45983","Q91Y86","A0A0G2KA63","A0A8I3PEK4",null,"F6ZKB3","GO:0030424; GO:0097441; GO:0005737; GO:0005829; GO:0043231; GO:0005739; GO:0005654; GO:0005634; GO:0045202","GO:0005524; GO:0019899; GO:0042826; GO:0035033; GO:0004705; GO:0016301; GO:0004707; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0120283; GO:0016740","GO:0034198; GO:0071276; GO:0071222; GO:0071260; GO:0034599; GO:0034614; GO:0090398; GO:0038095; GO:0035556; GO:0007254; GO:0007258; GO:0043066; GO:0032091; GO:0018105; GO:0018107; GO:0016310; GO:0043065; GO:0031343; GO:0031281; GO:0090045; GO:0010628; GO:1900227; GO:1900740; GO:0051247; GO:0006468; GO:0042752; GO:1902595; GO:0051090; GO:0016241; GO:0032880; GO:0009612; GO:0006979; GO:0009411; GO:0048511; GO:0007165; GO:0051403","PTHR24055:SF222","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6881|UniProtKB=P45983","P06959; P00053; P00052; P00010; P06664; P00021; P04393; P00035; P00034; P00047; P00005; P00054; P00049; P00046; P00018; P00003; P00020; P00006"]
["JNK/SAPK 1/2/3 - phospho","Tyr185/Tyr223","MAPK8, MAPK9, MAPK10","46","rb",null,2,2.1,4,4,1.1000000000000001,4,"# 0215",".ALZ., .ANG., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CRC., .CSP., .DEV., .DI., .EGFR., .FAS., .FGFR., .FOXO., .GPCR., .HEPB., .HUNT., .IMUF., .INFG., .INS., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .UBI., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; FAS signaling pathway; Apoptosis signaling pathway; Huntington disease","MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE 10","cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to oxidative stress; cellular response to reactive oxygen species; cellular senescence; Fc-epsilon receptor signaling pathway; intracellular signal transduction; JNK cascade; JUN phosphorylation; negative regulation of apoptotic process; negative regulation of protein binding; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of cell killing; positive regulation of cyclase activity; positive regulation of deacetylase activity; positive regulation of gene expression; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of protein metabolic process; protein phosphorylation; regulation of circadian rhythm; regulation of DNA replication origin binding; regulation of DNA-binding transcription factor activity; regulation of macroautophagy; regulation of protein localization; response to mechanical stimulus; response to oxidative stress; response to UV; rhythmic process; signal transduction; stress-activated MAPK cascade; apoptotic signaling pathway; modulation of chemical synaptic transmission; positive regulation of apoptotic signaling pathway; positive regulation of macrophage derived foam cell differentiation; positive regulation of podosome assembly; positive regulation of protein ubiquitination; positive regulation of transcription factor catabolic process; protein localization to tricellular tight junction; response to cadmium ion; response to light stimulus","ATP binding; enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; transferase activity; protein serine/threonine/tyrosine kinase activity; MAP kinase kinase activity","axon; basal dendrite; cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus; synapse; nuclear speck; plasma membrane; Schaffer collateral - CA1 synapse; membrane","MAPK signaling","mitogen-activated protein kinase 8; mitogen-activated protein kinase 9; mitogen-activated protein kinase 10","http://www.ncbi.nlm.nih.gov/gene/?term=5599, http://www.ncbi.nlm.nih.gov/gene/?term=5601, http://www.ncbi.nlm.nih.gov/gene/?term=5602","5599, 5601, 5602","26419, 26420, NA","NA, 50658",null,"396609, NA","711115, 715782, 699736","P45983, P45984, P53779","Q91Y86, Q9WTU6, A0A0G2JEJ8","A0A0G2KA63, A0A0G2JYS4, A0A0U1RRP0","A0A8I3PEK4, A0A8I3MYX4, A0A8I3PFZ4","A0A287APM5, A0A5G2QSE9","F6ZKB3, A0A1D5R2Q5, A0A1D5QMC7","GO:0030424; GO:0097441; GO:0005737; GO:0005829; GO:0043231; GO:0005739; GO:0005654; GO:0005634; GO:0045202; GO:0016607; GO:0005886; GO:0098685; GO:0016020","GO:0005524; GO:0019899; GO:0042826; GO:0035033; GO:0004705; GO:0016301; GO:0004707; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0120283; GO:0016740; GO:0004712; GO:0004708","GO:0034198; GO:0071276; GO:0071222; GO:0071260; GO:0034599; GO:0034614; GO:0090398; GO:0038095; GO:0035556; GO:0007254; GO:0007258; GO:0043066; GO:0032091; GO:0018105; GO:0018107; GO:0016310; GO:0043065; GO:0031343; GO:0031281; GO:0090045; GO:0010628; GO:1900227; GO:1900740; GO:0051247; GO:0006468; GO:0042752; GO:1902595; GO:0051090; GO:0016241; GO:0032880; GO:0009612; GO:0006979; GO:0009411; GO:0048511; GO:0007165; GO:0051403; GO:0097190; GO:0050804; GO:2001235; GO:0010744; GO:0071803; GO:0031398; GO:1901485; GO:0061833; GO:0046686; GO:0009416","PTHR24055:SF222; PTHR24055:SF172; PTHR24055:SF162","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6881|UniProtKB=P45983; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6886|UniProtKB=P45984; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6872|UniProtKB=P53779","P06959; P00053; P00052; P00010; P06664; P00021; P04393; P00035; P00034; P00047; P00005; P00054; P00049; P00046; P00018; P00003; P00020; P00006; P00029"]
["JNK1",null,"MAPK8","54, 46","ms",null,1,1,"n/a","n/a","n/a","n/a","# 1686",".ALZ., .ANG., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CRC., .CSP., .DEV., .DI., .EGFR., .FAS., .FGFR., .FOXO., .GPCR., .HEPB., .HUNT., .IMUF., .INFG., .INS., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 8","cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to oxidative stress; cellular response to reactive oxygen species; cellular senescence; Fc-epsilon receptor signaling pathway; intracellular signal transduction; JNK cascade; JUN phosphorylation; negative regulation of apoptotic process; negative regulation of protein binding; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of cell killing; positive regulation of cyclase activity; positive regulation of deacetylase activity; positive regulation of gene expression; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of protein metabolic process; protein phosphorylation; regulation of circadian rhythm; regulation of DNA replication origin binding; regulation of DNA-binding transcription factor activity; regulation of macroautophagy; regulation of protein localization; response to mechanical stimulus; response to oxidative stress; response to UV; rhythmic process; signal transduction; stress-activated MAPK cascade","ATP binding; enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; transferase activity","axon; basal dendrite; cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus; synapse","MAPK signaling","mitogen-activated protein kinase 8","http://www.ncbi.nlm.nih.gov/gene/?term=5599","5599","26419",null,null,null,"711115","P45983","Q91Y86","A0A0G2KA63","A0A8I3PEK4",null,"F6ZKB3","GO:0030424; GO:0097441; GO:0005737; GO:0005829; GO:0043231; GO:0005739; GO:0005654; GO:0005634; GO:0045202","GO:0005524; GO:0019899; GO:0042826; GO:0035033; GO:0004705; GO:0016301; GO:0004707; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0120283; GO:0016740","GO:0034198; GO:0071276; GO:0071222; GO:0071260; GO:0034599; GO:0034614; GO:0090398; GO:0038095; GO:0035556; GO:0007254; GO:0007258; GO:0043066; GO:0032091; GO:0018105; GO:0018107; GO:0016310; GO:0043065; GO:0031343; GO:0031281; GO:0090045; GO:0010628; GO:1900227; GO:1900740; GO:0051247; GO:0006468; GO:0042752; GO:1902595; GO:0051090; GO:0016241; GO:0032880; GO:0009612; GO:0006979; GO:0009411; GO:0048511; GO:0007165; GO:0051403","PTHR24055:SF222","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6881|UniProtKB=P45983","P06959; P00053; P00052; P00010; P06664; P00021; P04393; P00035; P00034; P00047; P00005; P00054; P00049; P00046; P00018; P00003; P00020; P00006"]
["JNK2",null,"MAPK9","54, 46","rb",null,1,1,"n/a","n/a","n/a","n/a","# 1781",".ALZ., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CRC., .CSP., .DEV., .DI., .EGFR., .FAS., .FGFR., .FOXO., .GPCR., .HEPB., .HUNT., .IMUF., .INFG., .INS., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .UBI., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Interferon-gamma signaling pathway; Integrin signalling pathway; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 9","apoptotic signaling pathway; cellular response to cadmium ion; cellular response to reactive oxygen species; cellular senescence; Fc-epsilon receptor signaling pathway; intracellular signal transduction; JNK cascade; modulation of chemical synaptic transmission; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic signaling pathway; positive regulation of gene expression; positive regulation of macrophage derived foam cell differentiation; positive regulation of podosome assembly; positive regulation of protein ubiquitination; positive regulation of transcription factor catabolic process; protein localization to tricellular tight junction; protein phosphorylation; regulation of circadian rhythm; regulation of DNA-binding transcription factor activity; response to cadmium ion; rhythmic process; signal transduction","ATP binding; JUN kinase activity; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transferase activity","cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrion; nuclear speck; nucleoplasm; nucleus; plasma membrane; Schaffer collateral - CA1 synapse","MAPK signaling","mitogen-activated protein kinase 9","http://www.ncbi.nlm.nih.gov/gene/?term=5601","5601","26420","50658",null,"396609","715782","P45984","Q9WTU6","A0A0G2JYS4","A0A8I3MYX4","A0A287APM5","A0A1D5R2Q5","GO:0005737; GO:0005829; GO:0043231; GO:0005739; GO:0016607; GO:0005654; GO:0005634; GO:0005886; GO:0098685","GO:0005524; GO:0004705; GO:0016301; GO:0004707; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0016740","GO:0097190; GO:0071276; GO:0034614; GO:0090398; GO:0038095; GO:0035556; GO:0007254; GO:0050804; GO:0018105; GO:0016310; GO:2001235; GO:0010628; GO:0010744; GO:0071803; GO:0031398; GO:1901485; GO:0061833; GO:0006468; GO:0042752; GO:0051090; GO:0046686; GO:0048511; GO:0007165","PTHR24055:SF172","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6886|UniProtKB=P45984","P06959; P00053; P00052; P00010; P06664; P00021; P04393; P00029; P00035; P00034; P00054; P00049; P00046; P00018; P00003; P00020; P00006"]
["JNK3",null,"MAPK10","54","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1690",".ALZ., .ANG., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CRC., .CSP., .DEV., .DI., .EGFR., .FAS., .FGFR., .FOXO., .GPCR., .HEPB., .HUNT., .IMUF., .INFG., .INS., .INT., .JNK., .MAPK., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .WNT.","CCKR signaling map; T cell activation; TGF-beta signaling pathway; B cell activation; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; FAS signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 10","cellular senescence; Fc-epsilon receptor signaling pathway; intracellular signal transduction; JNK cascade; phosphorylation; protein phosphorylation; regulation of circadian rhythm; regulation of DNA-binding transcription factor activity; response to light stimulus; rhythmic process; signal transduction","ATP binding; JUN kinase activity; kinase activity; MAP kinase activity; MAP kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; nucleoplasm; nucleus; plasma membrane",null,"mitogen-activated protein kinase 10","http://www.ncbi.nlm.nih.gov/gene/?term=5602","5602",null,null,null,null,"699736","P53779","A0A0G2JEJ8","A0A0U1RRP0","A0A8I3PFZ4","A0A5G2QSE9","A0A1D5QMC7","GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005739; GO:0005654; GO:0005634; GO:0005886","GO:0005524; GO:0004705; GO:0016301; GO:0004707; GO:0004708; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0090398; GO:0038095; GO:0035556; GO:0007254; GO:0016310; GO:0006468; GO:0042752; GO:0051090; GO:0009416; GO:0048511; GO:0007165","PTHR24055:SF162","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6872|UniProtKB=P53779","P06959; P00053; P00052; P00010; P00021; P04393; P00035; P00034; P00047; P00005; P00054; P00049; P00046; P00018; P00003; P00020; P00006"]
["KDELC2",null,"POGLUT3","59","rb",null,2,7,6,6,6,6,"# 0964",null,null,"PROTEIN O-GLUCOSYLTRANSFERASE 3","protein glycosylation; protein O-linked glycosylation via serine","EGF-domain serine glucosyltransferase activity; EGF-domain serine xylosyltransferase activity; glucosyltransferase activity; glycosyltransferase activity; transferase activity; UDP-glucosyltransferase activity; UDP-xylosyltransferase activity","cellular_component; endomembrane system; endoplasmic reticulum; endoplasmic reticulum lumen",null,"protein O-glucosyltransferase 3","http://www.ncbi.nlm.nih.gov/gene/?term=143888","143888","68304","315664",null,null,null,"Q7Z4H8","G5E897","Q566E5","A0A8I3MSK4","A0A5G2QVD9",null,"GO:0005575; GO:0012505; GO:0005783; GO:0005788","GO:0140561; GO:0140562; GO:0046527; GO:0016757; GO:0016740; GO:0035251; GO:0035252","GO:0006486; GO:0018242","PTHR12203:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=28496|UniProtKB=Q7Z4H8"]
["Ki-67",null,"MKI67","359, 319","rb",null,2,4,4,4,4,4,"BG/MP # 130",".CCP., .CCY., .CP., .OP.",null,"PROLIFERATION MARKER PROTEIN KI-67","cell cycle; cell population proliferation; regulation of chromatin organization; regulation of chromosome segregation; regulation of mitotic nuclear division","ATP binding; DNA binding; nucleotide binding; protein binding; protein C-terminus binding; RNA binding","chromosome; condensed chromosome; membrane; nuclear body; nucleolus; nucleoplasm; nucleus","Proliferation / tumor marker","marker of proliferation Ki-67","http://www.ncbi.nlm.nih.gov/gene/?term=4288","4288","17345","291234",null,null,null,"P46013","E9PVX6","D4A0Y6","A0A8P0PBD3","I3LF70","A0A1D5RER2","GO:0005694; GO:0000793; GO:0016020; GO:0016604; GO:0005730; GO:0005654; GO:0005634","GO:0005524; GO:0003677; GO:0000166; GO:0005515; GO:0008022; GO:0003723","GO:0007049; GO:0008283; GO:1902275; GO:0051983; GO:0007088","PTHR21603:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7107|UniProtKB=P46013"]
["KLF4",null,"KLF4","62","rb",null,2,4,4,4,1,4,"# 1283",".ANG., .APO., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .IMFR., .IMUR., .MIG., .OP., .OPA., .OT., .TRASR., .WNT.","CCKR signaling map","KRUEPPEL-LIKE FACTOR 4","canonical Wnt signaling pathway; cellular response to growth factor stimulus; cellular response to laminar fluid shear stress; cellular response to leukemia inhibitory factor; defense response to tumor cell; DNA-templated transcription; epidermal cell differentiation; epidermis development; epidermis morphogenesis; establishment of skin barrier; fat cell differentiation; gene expression; glandular epithelial cell differentiation; mesodermal cell fate determination; negative regulation of angiogenesis; negative regulation of cell migration; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of chemokine (C-X-C motif) ligand 2 production; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of interleukin-8 production; negative regulation of leukocyte adhesion to arterial endothelial cell; negative regulation of NF-kappaB transcription factor activity; negative regulation of response to cytokine stimulus; negative regulation of transcription by RNA polymerase II; positive regulation of core promoter binding; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of hemoglobin biosynthetic process; positive regulation of miRNA transcription; positive regulation of nitric oxide biosynthetic process; positive regulation of protein metabolic process; positive regulation of sprouting angiogenesis; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; post-embryonic camera-type eye development; post-embryonic hemopoiesis; regulation of axon regeneration; regulation of blastocyst development; regulation of cell differentiation; regulation of cell population proliferation; regulation of transcription by RNA polymerase II; response to organic substance; response to retinoic acid; somatic stem cell population maintenance; stem cell population maintenance; transcription by RNA polymerase II","beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; promoter-specific chromatin binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; zinc ion binding","chromatin; cytoplasm; cytosol; euchromatin; microtubule cytoskeleton; nucleoplasm; nucleus; transcription regulator complex","Development","KLF transcription factor 4","http://www.ncbi.nlm.nih.gov/gene/?term=9314","9314","16600",null,null,"595111",null,"O43474","Q60793","A0A8I5ZW83","A0A8P0PMB6","A0A5G2RA65","A0A5F8AGZ8","GO:0000785; GO:0005737; GO:0005829; GO:0000791; GO:0015630; GO:0005654; GO:0005634; GO:0005667","GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0046872; GO:1990841; GO:0005515; GO:0000978; GO:0001010; GO:0061629; GO:0043565; GO:1990837; GO:0000976; GO:0008270","GO:0060070; GO:0071363; GO:0071499; GO:1990830; GO:0002357; GO:0006351; GO:0009913; GO:0008544; GO:0048730; GO:0061436; GO:0045444; GO:0010467; GO:0002067; GO:0007500; GO:0016525; GO:0030336; GO:0090051; GO:0008285; GO:2000342; GO:0043154; GO:0043433; GO:0045892; GO:2000134; GO:0010629; GO:0034115; GO:0050728; GO:0032717; GO:1904998; GO:0032088; GO:0060761; GO:0000122; GO:1904798; GO:0045893; GO:0010628; GO:0046985; GO:1902895; GO:0045429; GO:0051247; GO:1903672; GO:0051973; GO:0045944; GO:0031077; GO:0035166; GO:0048679; GO:0120222; GO:0045595; GO:0042127; GO:0006357; GO:0010033; GO:0032526; GO:0035019; GO:0019827; GO:0006366","PTHR23235:SF117","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6348|UniProtKB=O43474","P06959"]
["KLF4",null,"KLF4","65","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2809",".ANG., .APO., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .IMFR., .IMUR., .MIG., .OP., .OPA., .OT., .TRASR., .WNT.","CCKR signaling map","KRUEPPEL-LIKE FACTOR 4","canonical Wnt signaling pathway; cellular response to growth factor stimulus; cellular response to laminar fluid shear stress; cellular response to leukemia inhibitory factor; defense response to tumor cell; DNA-templated transcription; epidermal cell differentiation; epidermis development; epidermis morphogenesis; establishment of skin barrier; fat cell differentiation; gene expression; glandular epithelial cell differentiation; mesodermal cell fate determination; negative regulation of angiogenesis; negative regulation of cell migration; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of chemokine (C-X-C motif) ligand 2 production; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of interleukin-8 production; negative regulation of leukocyte adhesion to arterial endothelial cell; negative regulation of NF-kappaB transcription factor activity; negative regulation of response to cytokine stimulus; negative regulation of transcription by RNA polymerase II; positive regulation of core promoter binding; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of hemoglobin biosynthetic process; positive regulation of miRNA transcription; positive regulation of nitric oxide biosynthetic process; positive regulation of protein metabolic process; positive regulation of sprouting angiogenesis; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; post-embryonic camera-type eye development; post-embryonic hemopoiesis; regulation of axon regeneration; regulation of blastocyst development; regulation of cell differentiation; regulation of cell population proliferation; regulation of transcription by RNA polymerase II; response to organic substance; response to retinoic acid; somatic stem cell population maintenance; stem cell population maintenance; transcription by RNA polymerase II","beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; promoter-specific chromatin binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; zinc ion binding","chromatin; cytoplasm; cytosol; euchromatin; microtubule cytoskeleton; nucleoplasm; nucleus; transcription regulator complex",null,"KLF transcription factor 4","http://www.ncbi.nlm.nih.gov/gene/?term=9314","9314","16600",null,null,"595111",null,"O43474","Q60793","A0A8I5ZW83","A0A8P0PMB6","A0A5G2RA65","A0A5F8AGZ8","GO:0000785; GO:0005737; GO:0005829; GO:0000791; GO:0015630; GO:0005654; GO:0005634; GO:0005667","GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0046872; GO:1990841; GO:0005515; GO:0000978; GO:0001010; GO:0061629; GO:0043565; GO:1990837; GO:0000976; GO:0008270","GO:0060070; GO:0071363; GO:0071499; GO:1990830; GO:0002357; GO:0006351; GO:0009913; GO:0008544; GO:0048730; GO:0061436; GO:0045444; GO:0010467; GO:0002067; GO:0007500; GO:0016525; GO:0030336; GO:0090051; GO:0008285; GO:2000342; GO:0043154; GO:0043433; GO:0045892; GO:2000134; GO:0010629; GO:0034115; GO:0050728; GO:0032717; GO:1904998; GO:0032088; GO:0060761; GO:0000122; GO:1904798; GO:0045893; GO:0010628; GO:0046985; GO:1902895; GO:0045429; GO:0051247; GO:1903672; GO:0051973; GO:0045944; GO:0031077; GO:0035166; GO:0048679; GO:0120222; GO:0045595; GO:0042127; GO:0006357; GO:0010033; GO:0032526; GO:0035019; GO:0019827; GO:0006366","PTHR23235:SF117","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6348|UniProtKB=O43474","P06959"]
["KLF5",null,"KLF5","51","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1700",".ANG., .CANCER., .CSP., .OP., .OPA., .OT., .ST., .TRASR.",null,"KRUEPPEL-LIKE FACTOR 5","angiogenesis; cell-cell signaling via exosome; cellular response to leukemia inhibitory factor; intestinal epithelial cell development; microvillus assembly; myotube differentiation involved in skeletal muscle regeneration; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by transcription factor localization; regulation of gene expression; regulation of microvillus assembly; regulation of transcription by RNA polymerase II; satellite cell activation involved in skeletal muscle regeneration; skeletal muscle cell differentiation; skeletal muscle satellite cell differentiation; skeletal muscle tissue regeneration","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; MRF binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; nucleus; transcription regulator complex",null,"KLF transcription factor 5","http://www.ncbi.nlm.nih.gov/gene/?term=688","688","12224",null,null,null,"694320","Q13887","Q9Z0Z7","F1LSL7","A0A8I3PLX6",null,"A0A1D5QBL7","GO:0000785; GO:0005794; GO:0043231; GO:0005654; GO:0005634; GO:0005667","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0046872; GO:0043426; GO:0005515; GO:0000978; GO:1990837","GO:0001525; GO:0099156; GO:1990830; GO:0060576; GO:0030033; GO:0014908; GO:0000122; GO:0045893; GO:0045600; GO:1902895; GO:0045944; GO:0061586; GO:0010468; GO:0032534; GO:0006357; GO:0014901; GO:0035914; GO:0014816; GO:0043403","PTHR23235:SF82","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6349|UniProtKB=Q13887"]
["KSR1",null,"KSR1","102","rb",null,2.1,7,4,4,4,4,"# 0397",".CCP., .CP., .CSP., .MAPK., .OP., .OPA., .RAS., .RTK., .ST.","Gonadotropin releasing hormone receptor pathway","KINASE SUPPRESSOR OF RAS 1","cAMP-mediated signaling; phosphorylation; positive regulation of MAPK cascade; protein phosphorylation; Ras protein signal transduction; regulation of cell population proliferation; regulation of MAP kinase activity; signal transduction","14-3-3 protein binding; ATP binding; kinase activity; MAP-kinase scaffold activity; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cell projection; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; protein-containing complex; ruffle membrane","MAPK signaling","kinase suppressor of ras 1","http://www.ncbi.nlm.nih.gov/gene/?term=8844","8844","16706",null,null,null,null,"Q8IVT5","Q61097","A0A8I5ZQW6","A0A8P0PKA6","A0A287A2I6","F7F1U6","GO:0042995; GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0043231; GO:0016020; GO:0005886; GO:0032991; GO:0032587","GO:0071889; GO:0005524; GO:0016301; GO:0005078; GO:0046872; GO:0000166; GO:0005515; GO:0008022; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0019933; GO:0016310; GO:0043410; GO:0006468; GO:0007265; GO:0042127; GO:0043405; GO:0007165","PTHR23257:SF716","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6465|UniProtKB=Q8IVT5","P06664"]
["KSR1 - phospho","Ser392","KSR1","102","rb",null,2,1,8,8,8,8,"# 0409",".CCP., .CP., .CSP., .MAPK., .OP., .OPA., .RAS., .RTK., .ST.","Gonadotropin releasing hormone receptor pathway","KINASE SUPPRESSOR OF RAS 1","cAMP-mediated signaling; phosphorylation; positive regulation of MAPK cascade; protein phosphorylation; Ras protein signal transduction; regulation of cell population proliferation; regulation of MAP kinase activity; signal transduction","14-3-3 protein binding; ATP binding; kinase activity; MAP-kinase scaffold activity; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cell projection; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; protein-containing complex; ruffle membrane","MAPK signaling","kinase suppressor of ras 1","http://www.ncbi.nlm.nih.gov/gene/?term=8844","8844","16706",null,null,null,null,"Q8IVT5","Q61097","A0A8I5ZQW6","A0A8P0PKA6","A0A287A2I6","F7F1U6","GO:0042995; GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0043231; GO:0016020; GO:0005886; GO:0032991; GO:0032587","GO:0071889; GO:0005524; GO:0016301; GO:0005078; GO:0046872; GO:0000166; GO:0005515; GO:0008022; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0019933; GO:0016310; GO:0043410; GO:0006468; GO:0007265; GO:0042127; GO:0043405; GO:0007165","PTHR23257:SF716","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6465|UniProtKB=Q8IVT5","P06664"]
["Ku80",null,"XRCC5","86","rb",null,1,1,8,8,1,8,"# 1373",".CCP., .CD., .CP., .CSP., .DDR., .DREP., .DRR., .IIR., .IMU., .IMUR., .OP., .OPA., .OT., .ST., .TRASR.",null,"X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5","activation of innate immune response; brain development; cellular hyperosmotic salinity response; cellular response to DNA damage stimulus; cellular response to fatty acid; cellular response to gamma radiation; cellular response to leukemia inhibitory factor; cellular response to X-ray; DNA duplex unwinding; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; hematopoietic stem cell differentiation; hematopoietic stem cell proliferation; immune system process; innate immune response; negative regulation of DNA-templated transcription; negative regulation of t-circle formation; neurogenesis; positive regulation of catalytic activity; positive regulation of neurogenesis; positive regulation of protein kinase activity; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein localization to chromosome, telomeric region; recombinational repair; regulation of smooth muscle cell proliferation; regulation of telomere maintenance; response to xenobiotic stimulus; ribosome biogenesis; small-subunit processome assembly; telomere maintenance","5'-deoxyribose-5-phosphate lyase activity; ATP binding; ATP hydrolysis activity; ATP-dependent activity, acting on DNA; damaged DNA binding; DNA binding; DNA end binding; DNA helicase activity; double-stranded DNA binding; double-stranded telomeric DNA binding; enzyme activator activity; helicase activity; hydrolase activity; nucleotide binding; protein binding; protein C-terminus binding; protein-containing complex binding; RNA binding; telomeric DNA binding; transcription cis-regulatory region binding; U3 snoRNA binding; ubiquitin protein ligase binding","chromosome; chromosome, telomeric region; cytoplasm; cytosol; DNA-dependent protein kinase complex; extracellular region; Ku70:Ku80 complex; membrane; nonhomologous end joining complex; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; plasma membrane; protein-containing complex; protein-DNA complex; ribonucleoprotein complex; secretory granule lumen; site of DNA damage; small-subunit processome","DNA damage","X-ray repair cross complementing 5","http://www.ncbi.nlm.nih.gov/gene/?term=7520","7520","22596",null,null,null,null,"P13010","P27641","G3V817","A0A8P0NFZ7","A0A286ZIV3","A0A5F8AEP6","GO:0005694; GO:0000781; GO:0005737; GO:0005829; GO:0070418; GO:0005576; GO:0043564; GO:0016020; GO:0070419; GO:0000783; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0032993; GO:1990904; GO:0034774; GO:0090734; GO:0032040","GO:0051575; GO:0005524; GO:0016887; GO:0008094; GO:0003684; GO:0003677; GO:0045027; GO:0003678; GO:0003690; GO:0003691; GO:0008047; GO:0004386; GO:0016787; GO:0000166; GO:0005515; GO:0008022; GO:0044877; GO:0003723; GO:0042162; GO:0000976; GO:0034511; GO:0031625","GO:0002218; GO:0007420; GO:0071475; GO:0006974; GO:0071398; GO:0071480; GO:1990830; GO:0071481; GO:0032508; GO:0006310; GO:0006281; GO:0006302; GO:0006303; GO:0060218; GO:0071425; GO:0002376; GO:0045087; GO:0045892; GO:1904430; GO:0022008; GO:0043085; GO:0050769; GO:0045860; GO:0051973; GO:0032212; GO:0070198; GO:0000725; GO:0048660; GO:0032204; GO:0009410; GO:0042254; GO:0034462; GO:0000723","PTHR12604:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12833|UniProtKB=P13010"]
["LAMP1",null,"LAMP1","120","ms",null,1,4,4,4,8,8,"# 0327",".APH., .CD., .CSP., .IMUR., .OP., .OPA., .ST., .VIR.",null,"LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1","establishment of protein localization to organelle; Golgi to lysosome transport; granzyme-mediated programmed cell death signaling pathway; positive regulation of natural killer cell degranulation; positive regulation of natural killer cell mediated cytotoxicity; protein stabilization; regulation of organelle transport along microtubule; viral entry into host cell","enzyme binding; protein binding; protein domain specific binding; virus receptor activity","autolysosome; autophagosome membrane; azurophil granule membrane; cell surface; cytolytic granule; cytolytic granule membrane; cytoplasm; cytosol; endosome; endosome membrane; external side of plasma membrane; extracellular exosome; ficolin-1-rich granule membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; melanosome; membrane; multivesicular body; perinuclear region of cytoplasm; phagocytic vesicle; phagolysosome membrane; plasma membrane; sarcolemma; synaptic vesicle; vesicle","Cytoskeletal regulation / Adhesion","lysosomal associated membrane protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=3916","3916","16783",null,"476995",null,null,"P11279","P11438","A0A0U1RRW1","A0A8I3PPW7","A0A5G2R3I8","F6Y0V7","GO:0044754; GO:0000421; GO:0035577; GO:0009986; GO:0044194; GO:0101004; GO:0005737; GO:0005829; GO:0005768; GO:0010008; GO:0009897; GO:0070062; GO:0101003; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0042470; GO:0016020; GO:0005771; GO:0048471; GO:0045335; GO:0061474; GO:0005886; GO:0042383; GO:0008021; GO:0031982","GO:0019899; GO:0005515; GO:0019904; GO:0001618","GO:0072594; GO:0090160; GO:0140507; GO:0043323; GO:0045954; GO:0050821; GO:1902513; GO:0046718","PTHR11506:SF27","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6499|UniProtKB=P11279"]
["LAT",null,"LAT","38, 36","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1951",".CSP., .IMFR., .IMU., .IMUF., .IMUR., .INT., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","T cell activation","LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 1","adaptive immune response; calcium-mediated signaling; gene expression; homeostasis of number of cells; immune response; immune system process; inflammatory response; integrin-mediated signaling pathway; intracellular signal transduction; lymphocyte homeostasis; mast cell degranulation; positive regulation of protein kinase activity; Ras protein signal transduction; regulation of T cell activation; signal transduction; T cell activation","protein binding; protein kinase binding; signaling receptor complex adaptor activity","cell-cell junction; COP9 signalosome; Golgi apparatus; immunological synapse; membrane; membrane raft; plasma membrane",null,"linker for activation of T cells","http://www.ncbi.nlm.nih.gov/gene/?term=27040","27040","16797","81511",null,null,null,"O43561","O54957","O70601","A0A8I3MMK3","A0A8W4FLF3","A0A1D5R072","GO:0005911; GO:0008180; GO:0005794; GO:0001772; GO:0016020; GO:0045121; GO:0005886","GO:0005515; GO:0019901; GO:0030159","GO:0002250; GO:0019722; GO:0010467; GO:0048872; GO:0006955; GO:0002376; GO:0006954; GO:0007229; GO:0035556; GO:0002260; GO:0043303; GO:0045860; GO:0007265; GO:0050863; GO:0007165; GO:0042110","PTHR15586:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18874|UniProtKB=O43561","P00053"]
["LAT - phospho","Tyr171","LAT","38, 36","rb",null,4,2,"n/a","n/a","n/a","n/a","# 1934",".CSP., .IMFR., .IMU., .IMUF., .IMUR., .INT., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","T cell activation","LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 1","adaptive immune response; calcium-mediated signaling; gene expression; homeostasis of number of cells; immune response; immune system process; inflammatory response; integrin-mediated signaling pathway; intracellular signal transduction; lymphocyte homeostasis; mast cell degranulation; positive regulation of protein kinase activity; Ras protein signal transduction; regulation of T cell activation; signal transduction; T cell activation","protein binding; protein kinase binding; signaling receptor complex adaptor activity","cell-cell junction; COP9 signalosome; Golgi apparatus; immunological synapse; membrane; membrane raft; plasma membrane",null,"linker for activation of T cells","http://www.ncbi.nlm.nih.gov/gene/?term=27040","27040","16797","81511",null,null,null,"O43561","O54957","O70601","A0A8I3MMK3","A0A8W4FLF3","A0A1D5R072","GO:0005911; GO:0008180; GO:0005794; GO:0001772; GO:0016020; GO:0045121; GO:0005886","GO:0005515; GO:0019901; GO:0030159","GO:0002250; GO:0019722; GO:0010467; GO:0048872; GO:0006955; GO:0002376; GO:0006954; GO:0007229; GO:0035556; GO:0002260; GO:0043303; GO:0045860; GO:0007265; GO:0050863; GO:0007165; GO:0042110","PTHR15586:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18874|UniProtKB=O43561","P00053"]
["LAT - phospho","Tyr191","LAT","38, 36","rb",null,4,2,"n/a","n/a","n/a","n/a","# 1937",".CSP., .IMFR., .IMU., .IMUF., .IMUR., .INT., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","T cell activation","LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 1","adaptive immune response; calcium-mediated signaling; gene expression; homeostasis of number of cells; immune response; immune system process; inflammatory response; integrin-mediated signaling pathway; intracellular signal transduction; lymphocyte homeostasis; mast cell degranulation; positive regulation of protein kinase activity; Ras protein signal transduction; regulation of T cell activation; signal transduction; T cell activation","protein binding; protein kinase binding; signaling receptor complex adaptor activity","cell-cell junction; COP9 signalosome; Golgi apparatus; immunological synapse; membrane; membrane raft; plasma membrane",null,"linker for activation of T cells","http://www.ncbi.nlm.nih.gov/gene/?term=27040","27040","16797","81511",null,null,null,"O43561","O54957","O70601","A0A8I3MMK3","A0A8W4FLF3","A0A1D5R072","GO:0005911; GO:0008180; GO:0005794; GO:0001772; GO:0016020; GO:0045121; GO:0005886","GO:0005515; GO:0019901; GO:0030159","GO:0002250; GO:0019722; GO:0010467; GO:0048872; GO:0006955; GO:0002376; GO:0006954; GO:0007229; GO:0035556; GO:0002260; GO:0043303; GO:0045860; GO:0007265; GO:0050863; GO:0007165; GO:0042110","PTHR15586:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18874|UniProtKB=O43561","P00053"]
["LATS1",null,"LATS1","140","rb",null,1.1000000000000001,4,4,4,4,4,"# 1251",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HIPPO., .OP., .OPA., .ST., .TGFB., .WNT.",null,"SERINE/THREONINE-PROTEIN KINASE LATS1","cell cycle; cell division; cytoplasmic sequestering of protein; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; hippo signaling; hormone-mediated signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; intracellular signal transduction; keratinocyte differentiation; mammary gland epithelial cell differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of peptidyl-serine phosphorylation; protein localization; protein phosphorylation; regulation of actin filament polymerization; regulation of intracellular estrogen receptor signaling pathway; regulation of organ growth; regulation of protein-containing complex assembly; regulation of transforming growth factor beta receptor signaling pathway; regulation of ubiquitin-dependent protein catabolic process; sister chromatid segregation","ATP binding; kinase activity; magnesium ion binding; metal ion binding; nuclear estrogen receptor binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytoskeleton; cytosol; microtubule organizing center; midbody; nucleus; spindle; spindle pole","Hippo signaling","large tumor suppressor kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=9113","9113","16798","308265",null,null,null,"O95835","Q8BYR2","F1M2K4","A0A8I3S3J7","A0A287AKM7","A0A5F8A5L6","GO:0005737; GO:0005856; GO:0005829; GO:0005815; GO:0030496; GO:0005634; GO:0005819; GO:0000922","GO:0005524; GO:0016301; GO:0000287; GO:0046872; GO:0030331; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0051301; GO:0051220; GO:0000082; GO:0000086; GO:0035329; GO:0009755; GO:0001827; GO:0001828; GO:0035556; GO:0030216; GO:0060644; GO:0090090; GO:0045736; GO:1900181; GO:0018105; GO:0016310; GO:0043065; GO:0033138; GO:0008104; GO:0006468; GO:0030833; GO:0033146; GO:0046620; GO:0043254; GO:0017015; GO:2000058; GO:0000819","PTHR24356:SF138","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6514|UniProtKB=O95835"]
["LATS1 - phospho","Ser909","LATS1","140","rb",null,2,7,4,4,2,8,"# 1547",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HIPPO., .OP., .OPA., .ST., .TGFB., .WNT.",null,"SERINE/THREONINE-PROTEIN KINASE LATS1","cell cycle; cell division; cytoplasmic sequestering of protein; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; hippo signaling; hormone-mediated signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; intracellular signal transduction; keratinocyte differentiation; mammary gland epithelial cell differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of peptidyl-serine phosphorylation; protein localization; protein phosphorylation; regulation of actin filament polymerization; regulation of intracellular estrogen receptor signaling pathway; regulation of organ growth; regulation of protein-containing complex assembly; regulation of transforming growth factor beta receptor signaling pathway; regulation of ubiquitin-dependent protein catabolic process; sister chromatid segregation","ATP binding; kinase activity; magnesium ion binding; metal ion binding; nuclear estrogen receptor binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytoskeleton; cytosol; microtubule organizing center; midbody; nucleus; spindle; spindle pole","Hippo signaling","large tumor suppressor kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=9113","9113","16798","308265",null,null,null,"O95835","Q8BYR2","F1M2K4","A0A8I3S3J7","A0A287AKM7","A0A5F8A5L6","GO:0005737; GO:0005856; GO:0005829; GO:0005815; GO:0030496; GO:0005634; GO:0005819; GO:0000922","GO:0005524; GO:0016301; GO:0000287; GO:0046872; GO:0030331; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0051301; GO:0051220; GO:0000082; GO:0000086; GO:0035329; GO:0009755; GO:0001827; GO:0001828; GO:0035556; GO:0030216; GO:0060644; GO:0090090; GO:0045736; GO:1900181; GO:0018105; GO:0016310; GO:0043065; GO:0033138; GO:0008104; GO:0006468; GO:0030833; GO:0033146; GO:0046620; GO:0043254; GO:0017015; GO:2000058; GO:0000819","PTHR24356:SF138","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6514|UniProtKB=O95835"]
["LATS1 - phospho","Thr1079","LATS1","140","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1250",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HIPPO., .OP., .OPA., .ST., .TGFB., .WNT.",null,"SERINE/THREONINE-PROTEIN KINASE LATS1","cell cycle; cell division; cytoplasmic sequestering of protein; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; hippo signaling; hormone-mediated signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; intracellular signal transduction; keratinocyte differentiation; mammary gland epithelial cell differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of peptidyl-serine phosphorylation; protein localization; protein phosphorylation; regulation of actin filament polymerization; regulation of intracellular estrogen receptor signaling pathway; regulation of organ growth; regulation of protein-containing complex assembly; regulation of transforming growth factor beta receptor signaling pathway; regulation of ubiquitin-dependent protein catabolic process; sister chromatid segregation","ATP binding; kinase activity; magnesium ion binding; metal ion binding; nuclear estrogen receptor binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytoskeleton; cytosol; microtubule organizing center; midbody; nucleus; spindle; spindle pole","Hippo signaling","large tumor suppressor kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=9113","9113","16798","308265",null,null,null,"O95835","Q8BYR2","F1M2K4","A0A8I3S3J7","A0A287AKM7","A0A5F8A5L6","GO:0005737; GO:0005856; GO:0005829; GO:0005815; GO:0030496; GO:0005634; GO:0005819; GO:0000922","GO:0005524; GO:0016301; GO:0000287; GO:0046872; GO:0030331; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0051301; GO:0051220; GO:0000082; GO:0000086; GO:0035329; GO:0009755; GO:0001827; GO:0001828; GO:0035556; GO:0030216; GO:0060644; GO:0090090; GO:0045736; GO:1900181; GO:0018105; GO:0016310; GO:0043065; GO:0033138; GO:0008104; GO:0006468; GO:0030833; GO:0033146; GO:0046620; GO:0043254; GO:0017015; GO:2000058; GO:0000819","PTHR24356:SF138","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6514|UniProtKB=O95835"]
["LATS2",null,"LATS2","150","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1306",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HIPPO., .OP., .OPA., .ST., .TGFB., .WNT.",null,"SERINE/THREONINE-PROTEIN KINASE LATS2","canonical Wnt signaling pathway; cell cycle; cell division; G1/S transition of mitotic cell cycle; hippo signaling; hormone-mediated signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; intracellular signal transduction; keratinocyte differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; protein localization; protein phosphorylation; regulation of organ growth; regulation of transforming growth factor beta receptor signaling pathway","ATP binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","centriolar satellite; cytoplasm; cytoskeleton; cytosol; microtubule organizing center; nucleus; spindle pole","Hippo signaling","large tumor suppressor kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=26524","26524","50523","305922",null,null,"699957","Q9NRM7","Q7TSJ6","A0A0G2K4A8","A0A8P0N9S7",null,"H9H421","GO:0034451; GO:0005737; GO:0005856; GO:0005829; GO:0005815; GO:0005634; GO:0000922","GO:0005524; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0060070; GO:0007049; GO:0051301; GO:0000082; GO:0035329; GO:0009755; GO:0001827; GO:0001828; GO:0035556; GO:0030216; GO:0090090; GO:0045736; GO:1900181; GO:0018105; GO:0016310; GO:0043065; GO:0008104; GO:0006468; GO:0046620; GO:0017015","PTHR24356:SF149","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6515|UniProtKB=Q9NRM7"]
["LC3A",null,"MAP1LC3A","14","rb",null,6,7,"n/a","n/a","n/a","n/a","# 0615",".APH., .CD., .CSP., .OXS., .SREME.",null,"MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3A","autophagosome assembly; autophagosome maturation; autophagy; autophagy of mitochondrion; cellular response to amino acid starvation; cellular response to copper ion; cellular response to hydrogen peroxide; cellular response to nitrogen starvation; cellular response to starvation; macroautophagy; response to iron(II) ion; response to lead ion; response to morphine; response to nutrient levels","microtubule binding; phospholipid binding; protein binding; ubiquitin protein ligase binding","autolysosome; autophagosome; autophagosome membrane; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endomembrane system; glutamatergic synapse; intracellular membrane-bounded organelle; late endosome; membrane; microtubule; organelle membrane; synapse",null,"microtubule associated protein 1 light chain 3 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=84557","84557","66734","362245",null,"100322893",null,"Q9H492","Q91VR7","Q6XVN8",null,"D2KQR0","A0A1D5QDJ4","GO:0044754; GO:0005776; GO:0000421; GO:0005737; GO:0031410; GO:0005856; GO:0005829; GO:0012505; GO:0098978; GO:0043231; GO:0005770; GO:0016020; GO:0005874; GO:0031090; GO:0045202","GO:0008017; GO:0005543; GO:0005515; GO:0031625","GO:0000045; GO:0097352; GO:0006914; GO:0000422; GO:0034198; GO:0071280; GO:0070301; GO:0006995; GO:0009267; GO:0016236; GO:0010040; GO:0010288; GO:0043278; GO:0031667","PTHR10969:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6838|UniProtKB=Q9H492"]
["LC3B",null,"MAP1LC3B","18, 16","ms",null,7,4,4,4,4,4,"# 0616",".APH., .CD., .CSP.",null,"MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3 BETA 2-RELATED","autophagosome assembly; autophagosome maturation; autophagy; autophagy of mitochondrion; cellular response to nitrogen starvation; cellular response to starvation; macroautophagy; mitophagy","ceramide binding; microtubule binding; protein binding; ubiquitin protein ligase binding","autophagosome; autophagosome membrane; axoneme; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endomembrane system; intracellular membrane-bounded organelle; membrane; microtubule; mitochondrial membrane; mitochondrion; organelle membrane","Autophagy","microtubule associated protein 1 light chain 3 beta","http://www.ncbi.nlm.nih.gov/gene/?term=81631","81631","67443",null,null,null,null,"Q9GZQ8","Q9CQV6","A0A0G2K9Q7","A0A8I3MNZ3","A0A287B8I0",null,"GO:0005776; GO:0000421; GO:0005930; GO:0005737; GO:0031410; GO:0005856; GO:0005829; GO:0012505; GO:0043231; GO:0016020; GO:0005874; GO:0031966; GO:0005739; GO:0031090","GO:0097001; GO:0008017; GO:0005515; GO:0031625","GO:0000045; GO:0097352; GO:0006914; GO:0000422; GO:0006995; GO:0009267; GO:0016236; GO:0000423","PTHR10969:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13352|UniProtKB=Q9GZQ8"]
["LC3B",null,"MAP1LC3B","16, 14","rb",null,2,1,"n/a","n/a","n/a","n/a","# 2278",".APH., .CD., .CSP.",null,"MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3 BETA 2-RELATED","autophagosome assembly; autophagosome maturation; autophagy; autophagy of mitochondrion; cellular response to nitrogen starvation; cellular response to starvation; macroautophagy; mitophagy","ceramide binding; microtubule binding; protein binding; ubiquitin protein ligase binding","autophagosome; autophagosome membrane; axoneme; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endomembrane system; intracellular membrane-bounded organelle; membrane; microtubule; mitochondrial membrane; mitochondrion; organelle membrane","Autophagy","microtubule associated protein 1 light chain 3 beta","http://www.ncbi.nlm.nih.gov/gene/?term=81631","81631","67443",null,null,null,null,"Q9GZQ8","Q9CQV6","A0A0G2K9Q7","A0A8I3MNZ3","A0A287B8I0",null,"GO:0005776; GO:0000421; GO:0005930; GO:0005737; GO:0031410; GO:0005856; GO:0005829; GO:0012505; GO:0043231; GO:0016020; GO:0005874; GO:0031966; GO:0005739; GO:0031090","GO:0097001; GO:0008017; GO:0005515; GO:0031625","GO:0000045; GO:0097352; GO:0006914; GO:0000422; GO:0006995; GO:0009267; GO:0016236; GO:0000423","PTHR10969:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13352|UniProtKB=Q9GZQ8"]
["Lck",null,"LCK","56","rb",null,6,2,2,7,6,6,"# 1172",".APO., .BCR., .CD., .CSP., .DI., .DRR., .IIR., .IMUF., .IMUR., .LMIG., .MIG., .NFKB., .OP., .OPA., .OT., .PARK., .PLAT., .ST., .TCD., .TCR., .TMAT.","T cell activation; Parkinson disease","TYROSINE-PROTEIN KINASE LCK","activation of cysteine-type endopeptidase activity involved in apoptotic process; B cell receptor signaling pathway; cell differentiation; cellular zinc ion homeostasis; Fc-gamma receptor signaling pathway; hemopoiesis; innate immune response; intracellular signal transduction; leukocyte migration; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet activation; positive regulation of heterotypic cell-cell adhesion; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of leukocyte cell-cell adhesion; positive regulation of T cell activation; positive regulation of T cell receptor signaling pathway; protein phosphorylation; regulation of lymphocyte activation; release of sequestered calcium ion into cytosol; response to xenobiotic stimulus; T cell costimulation; T cell differentiation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; phospholipase activator activity; phospholipase binding; phosphotyrosine residue binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine/threonine phosphatase activity; protein tyrosine kinase activity; SH2 domain binding; signaling receptor binding; T cell receptor binding; transferase activity","cytoplasm; cytosol; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; immunological synapse; membrane; membrane raft; pericentriolar material; plasma membrane","Cell growth / differentiation","LCK proto-oncogene, Src family tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3932","3932","16818","313050","478151",null,"717704","P06239","P06240","A0A0H2UHH7","A0A8I3NAC6","A0A287AH06","A0A1D5Q9I1","GO:0005737; GO:0005829; GO:0070062; GO:0031234; GO:0001772; GO:0016020; GO:0045121; GO:0000242; GO:0005886","GO:0005524; GO:0051117; GO:0042609; GO:0042610; GO:0042802; GO:0016301; GO:0004715; GO:0000166; GO:0043548; GO:0016004; GO:0043274; GO:0001784; GO:0005515; GO:0008022; GO:0004672; GO:0019901; GO:0019903; GO:0004722; GO:0004713; GO:0042169; GO:0005102; GO:0042608; GO:0016740","GO:0006919; GO:0050853; GO:0030154; GO:0006882; GO:0038094; GO:0030097; GO:0045087; GO:0035556; GO:0050900; GO:0038083; GO:0018108; GO:0016310; GO:0030168; GO:0034116; GO:2001244; GO:1903039; GO:0050870; GO:0050862; GO:0006468; GO:0051249; GO:0051209; GO:0009410; GO:0031295; GO:0030217; GO:0050852; GO:0007169","PTHR24418:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6524|UniProtKB=P06239","P00053; P00049"]
["Lck",null,"LCK","56","rb",null,1,4,"n/a","n/a","n/a","n/a","# 1935",".APO., .BCR., .CD., .CSP., .DI., .DRR., .IIR., .IMUF., .IMUR., .LMIG., .MIG., .NFKB., .OP., .OPA., .OT., .PARK., .PLAT., .ST., .TCD., .TCR., .TMAT.","T cell activation; Parkinson disease","TYROSINE-PROTEIN KINASE LCK","activation of cysteine-type endopeptidase activity involved in apoptotic process; B cell receptor signaling pathway; cell differentiation; cellular zinc ion homeostasis; Fc-gamma receptor signaling pathway; hemopoiesis; innate immune response; intracellular signal transduction; leukocyte migration; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet activation; positive regulation of heterotypic cell-cell adhesion; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of leukocyte cell-cell adhesion; positive regulation of T cell activation; positive regulation of T cell receptor signaling pathway; protein phosphorylation; regulation of lymphocyte activation; release of sequestered calcium ion into cytosol; response to xenobiotic stimulus; T cell costimulation; T cell differentiation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; phospholipase activator activity; phospholipase binding; phosphotyrosine residue binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine/threonine phosphatase activity; protein tyrosine kinase activity; SH2 domain binding; signaling receptor binding; T cell receptor binding; transferase activity","cytoplasm; cytosol; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; immunological synapse; membrane; membrane raft; pericentriolar material; plasma membrane","Cell growth / differentiation","LCK proto-oncogene, Src family tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3932","3932","16818","313050","478151",null,"717704","P06239","P06240","A0A0H2UHH7","A0A8I3NAC6","A0A287AH06","A0A1D5Q9I1","GO:0005737; GO:0005829; GO:0070062; GO:0031234; GO:0001772; GO:0016020; GO:0045121; GO:0000242; GO:0005886","GO:0005524; GO:0051117; GO:0042609; GO:0042610; GO:0042802; GO:0016301; GO:0004715; GO:0000166; GO:0043548; GO:0016004; GO:0043274; GO:0001784; GO:0005515; GO:0008022; GO:0004672; GO:0019901; GO:0019903; GO:0004722; GO:0004713; GO:0042169; GO:0005102; GO:0042608; GO:0016740","GO:0006919; GO:0050853; GO:0030154; GO:0006882; GO:0038094; GO:0030097; GO:0045087; GO:0035556; GO:0050900; GO:0038083; GO:0018108; GO:0016310; GO:0030168; GO:0034116; GO:2001244; GO:1903039; GO:0050870; GO:0050862; GO:0006468; GO:0051249; GO:0051209; GO:0009410; GO:0031295; GO:0030217; GO:0050852; GO:0007169","PTHR24418:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6524|UniProtKB=P06239","P00053; P00049"]
["Lck - phospho","Tyr394","LCK","56","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1977",".APO., .BCR., .CD., .CSP., .DI., .DRR., .IIR., .IMUF., .IMUR., .LMIG., .MIG., .NFKB., .OP., .OPA., .OT., .PARK., .PLAT., .ST., .TCD., .TCR., .TMAT.","T cell activation; Parkinson disease","TYROSINE-PROTEIN KINASE LCK","activation of cysteine-type endopeptidase activity involved in apoptotic process; B cell receptor signaling pathway; cell differentiation; cellular zinc ion homeostasis; Fc-gamma receptor signaling pathway; hemopoiesis; innate immune response; intracellular signal transduction; leukocyte migration; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet activation; positive regulation of heterotypic cell-cell adhesion; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of leukocyte cell-cell adhesion; positive regulation of T cell activation; positive regulation of T cell receptor signaling pathway; protein phosphorylation; regulation of lymphocyte activation; release of sequestered calcium ion into cytosol; response to xenobiotic stimulus; T cell costimulation; T cell differentiation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; phospholipase activator activity; phospholipase binding; phosphotyrosine residue binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine/threonine phosphatase activity; protein tyrosine kinase activity; SH2 domain binding; signaling receptor binding; T cell receptor binding; transferase activity","cytoplasm; cytosol; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; immunological synapse; membrane; membrane raft; pericentriolar material; plasma membrane",null,"LCK proto-oncogene, Src family tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3932","3932","16818","313050","478151",null,"717704","P06239","P06240","A0A0H2UHH7","A0A8I3NAC6","A0A287AH06","A0A1D5Q9I1","GO:0005737; GO:0005829; GO:0070062; GO:0031234; GO:0001772; GO:0016020; GO:0045121; GO:0000242; GO:0005886","GO:0005524; GO:0051117; GO:0042609; GO:0042610; GO:0042802; GO:0016301; GO:0004715; GO:0000166; GO:0043548; GO:0016004; GO:0043274; GO:0001784; GO:0005515; GO:0008022; GO:0004672; GO:0019901; GO:0019903; GO:0004722; GO:0004713; GO:0042169; GO:0005102; GO:0042608; GO:0016740","GO:0006919; GO:0050853; GO:0030154; GO:0006882; GO:0038094; GO:0030097; GO:0045087; GO:0035556; GO:0050900; GO:0038083; GO:0018108; GO:0016310; GO:0030168; GO:0034116; GO:2001244; GO:1903039; GO:0050870; GO:0050862; GO:0006468; GO:0051249; GO:0051209; GO:0009410; GO:0031295; GO:0030217; GO:0050852; GO:0007169","PTHR24418:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6524|UniProtKB=P06239","P00053; P00049"]
["Lck - phospho","Tyr505","LCK","56","rb",null,1.1000000000000001,1,8.1,8,8.1,8,"# 1487",".APO., .BCR., .CD., .CSP., .DI., .DRR., .IIR., .IMUF., .IMUR., .LMIG., .MIG., .NFKB., .OP., .OPA., .OT., .PARK., .PLAT., .ST., .TCD., .TCR., .TMAT.","T cell activation; Parkinson disease","TYROSINE-PROTEIN KINASE LCK","activation of cysteine-type endopeptidase activity involved in apoptotic process; B cell receptor signaling pathway; cell differentiation; cellular zinc ion homeostasis; Fc-gamma receptor signaling pathway; hemopoiesis; innate immune response; intracellular signal transduction; leukocyte migration; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet activation; positive regulation of heterotypic cell-cell adhesion; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of leukocyte cell-cell adhesion; positive regulation of T cell activation; positive regulation of T cell receptor signaling pathway; protein phosphorylation; regulation of lymphocyte activation; release of sequestered calcium ion into cytosol; response to xenobiotic stimulus; T cell costimulation; T cell differentiation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; ATPase binding; CD4 receptor binding; CD8 receptor binding; identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; phospholipase activator activity; phospholipase binding; phosphotyrosine residue binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine/threonine phosphatase activity; protein tyrosine kinase activity; SH2 domain binding; signaling receptor binding; T cell receptor binding; transferase activity","cytoplasm; cytosol; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; immunological synapse; membrane; membrane raft; pericentriolar material; plasma membrane","Cell growth / differentiation","LCK proto-oncogene, Src family tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=3932","3932","16818","313050","478151",null,"717704","P06239","P06240","A0A0H2UHH7","A0A8I3NAC6","A0A287AH06","A0A1D5Q9I1","GO:0005737; GO:0005829; GO:0070062; GO:0031234; GO:0001772; GO:0016020; GO:0045121; GO:0000242; GO:0005886","GO:0005524; GO:0051117; GO:0042609; GO:0042610; GO:0042802; GO:0016301; GO:0004715; GO:0000166; GO:0043548; GO:0016004; GO:0043274; GO:0001784; GO:0005515; GO:0008022; GO:0004672; GO:0019901; GO:0019903; GO:0004722; GO:0004713; GO:0042169; GO:0005102; GO:0042608; GO:0016740","GO:0006919; GO:0050853; GO:0030154; GO:0006882; GO:0038094; GO:0030097; GO:0045087; GO:0035556; GO:0050900; GO:0038083; GO:0018108; GO:0016310; GO:0030168; GO:0034116; GO:2001244; GO:1903039; GO:0050870; GO:0050862; GO:0006468; GO:0051249; GO:0051209; GO:0009410; GO:0031295; GO:0030217; GO:0050852; GO:0007169","PTHR24418:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6524|UniProtKB=P06239","P00053; P00049"]
["LCN2",null,"LCN2","25","rb",null,2,7,2,6,2,6,"# 1962",".APO., .CD., .CSP., .IIR., .IMU., .IMUR., .OP.",null,"NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","apoptotic process; defense response to bacterium; immune system process; innate immune response; ion transport; iron ion homeostasis; positive regulation of cold-induced thermogenesis; sequestering of iron ion; siderophore transport","enterobactin binding; identical protein binding; iron ion binding; protein binding; small molecule binding","cytoplasmic vesicle; cytoplasmic vesicle lumen; extracellular exosome; extracellular region; extracellular space; specific granule lumen","Apoptosis","lipocalin 2","http://www.ncbi.nlm.nih.gov/gene/?term=3934","3934","16819","170496",null,null,null,"P80188","P11672","P30152","A0A8I3Q9B0","A0A287BJ65","H9H4D4","GO:0031410; GO:0060205; GO:0070062; GO:0005576; GO:0005615; GO:0035580","GO:1903981; GO:0042802; GO:0005506; GO:0005515; GO:0036094","GO:0006915; GO:0042742; GO:0002376; GO:0045087; GO:0006811; GO:0055072; GO:0120162; GO:0097577; GO:0015891","PTHR11430:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6526|UniProtKB=P80188"]
["LDHA",null,"LDHA","37","rb",null,1,1,1,1,2,8,"# 1124",".CAMET., .CANCER., .CSP., .HIF., .OP., .SREME.",null,"L-LACTATE DEHYDROGENASE A CHAIN","carboxylic acid metabolic process; glycolytic process; lactate metabolic process; pyruvate metabolic process","cadherin binding; catalytic activity; identical protein binding; L-lactate dehydrogenase activity; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding","cytoplasm; cytosol; extracellular exosome; membrane; nucleus; oxidoreductase complex","Metabolism","lactate dehydrogenase A","http://www.ncbi.nlm.nih.gov/gene/?term=3939","3939","16828","24533",null,null,null,"P00338","P06151","P04642","A0A8P0NR20","P00339","F7E6F6","GO:0005737; GO:0005829; GO:0070062; GO:0016020; GO:0005634; GO:1990204","GO:0045296; GO:0003824; GO:0042802; GO:0004459; GO:0016491; GO:0016616; GO:0005515","GO:0019752; GO:0006096; GO:0006089; GO:0006090","PTHR43128:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6535|UniProtKB=P00338"]
["LEF1",null,"LEF1","58-25","rb",null,1.1000000000000001,4,4,7,4,4,"# 1470",".ALZ., .AML., .ANG., .APO., .BCR., .BMP., .BRC., .CADH., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .DEV., .DI., .EMC., .HIPPO., .IMUF., .IMUR., .MIG., .OP., .OPA., .OT., .PRC., .TCD., .TCR., .TMAT., .TRASR., .TYR., .VIR., .WNT.","Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Wnt signaling pathway","LYMPHOID ENHANCER-BINDING FACTOR 1","alpha-beta T cell differentiation; anatomical structure regression; apoptotic process involved in blood vessel morphogenesis; apoptotic process involved in morphogenesis; B cell proliferation; BMP signaling pathway; branching involved in blood vessel morphogenesis; canonical Wnt signaling pathway; cell chemotaxis; cell development; cellular response to cytokine stimulus; cellular response to interleukin-4; chorio-allantoic fusion; dentate gyrus development; embryonic limb morphogenesis; epithelial cell apoptotic process; epithelial to mesenchymal transition; face morphogenesis; forebrain neuroblast division; forebrain radial glial cell differentiation; formation of radial glial scaffolds; hippocampus development; histone H3-K56 acetylation; mammary gland development; negative regulation of apoptotic process; negative regulation of apoptotic process in bone marrow cell; negative regulation of DNA binding; negative regulation of DNA-templated transcription; negative regulation of interleukin-13 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; negative regulation of striated muscle tissue development; negative regulation of transcription by RNA polymerase II; neutrophil differentiation; odontogenesis of dentin-containing tooth; osteoblast differentiation; paraxial mesoderm formation; positive regulation by host of viral transcription; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of cell proliferation in bone marrow; positive regulation of chondrocyte proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of gamma-delta T cell differentiation; positive regulation of gene expression; positive regulation of granulocyte differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of Wnt signaling pathway; protein localization to chromatin; regulation of cell-cell adhesion; regulation of DNA-templated transcription; regulation of neurogenesis; regulation of transcription by RNA polymerase II; regulation of Wnt signaling pathway; secondary palate development; sensory perception of taste; somitogenesis; sprouting angiogenesis; T cell receptor V(D)J recombination; T-helper 1 cell differentiation; tongue development; trachea gland development; transcription by RNA polymerase II; vasculature development; Wnt signaling pathway","armadillo repeat domain binding; beta-catenin binding; C2H2 zinc finger domain binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA binding, bending; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; gamma-catenin binding; histone binding; histone deacetylase binding; nuclear estrogen receptor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription corepressor binding; transcription regulator inhibitor activity","beta-catenin-TCF complex; cytoplasm; nucleoplasm; nucleus; protein-DNA complex; RNA polymerase II transcription regulator complex; transcription regulator complex","Wnt signaling","lymphoid enhancer binding factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=51176","51176","16842","161452",null,null,"695776","Q9UJU2","P27782","A0A8I5Y632","A0A8I3Q381","A0A286ZR78","A0A1D5Q829","GO:1990907; GO:0005737; GO:0005654; GO:0005634; GO:0032993; GO:0090575; GO:0005667","GO:0070016; GO:0008013; GO:0070742; GO:0003682; GO:0000987; GO:0003677; GO:0008301; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0045295; GO:0042393; GO:0042826; GO:0030331; GO:0005515; GO:0000978; GO:0000977; GO:0043565; GO:1990837; GO:0000976; GO:0001222; GO:0140416","GO:0046632; GO:0060033; GO:1902262; GO:0060561; GO:0042100; GO:0030509; GO:0001569; GO:0060070; GO:0060326; GO:0048468; GO:0071345; GO:0071353; GO:0060710; GO:0021542; GO:0030326; GO:1904019; GO:0001837; GO:0060325; GO:0021873; GO:0021861; GO:0021943; GO:0021766; GO:0097043; GO:0030879; GO:0043066; GO:0071866; GO:0043392; GO:0045892; GO:0032696; GO:0032713; GO:0032714; GO:0045843; GO:0000122; GO:0030223; GO:0042475; GO:0001649; GO:0048341; GO:0043923; GO:0045597; GO:0030335; GO:0071864; GO:1902732; GO:0045893; GO:0010718; GO:0045588; GO:0010628; GO:0030854; GO:0045944; GO:0030177; GO:0071168; GO:0022407; GO:0006355; GO:0050767; GO:0006357; GO:0030111; GO:0062009; GO:0050909; GO:0001756; GO:0002040; GO:0033153; GO:0045063; GO:0043586; GO:0061153; GO:0006366; GO:0001944; GO:0016055","PTHR10373:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6551|UniProtKB=Q9UJU2","P00004; P00012; P00057"]
["LGR4",null,"LGR4","104","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1865",".CCP., .CP., .CSP., .DEV., .GPCR., .GPROT., .IIR., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .ST., .TOLL., .TRASR., .WNT.",null,"LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 4","bone mineralization; bone remodeling; canonical Wnt signaling pathway involved in metanephric kidney development; cell differentiation; cell differentiation involved in metanephros development; circadian regulation of gene expression; circadian rhythm; digestive tract development; epithelial cell proliferation; epithelial cell proliferation involved in renal tubule morphogenesis; G protein-coupled receptor signaling pathway; hair follicle development; immune system process; innate immune response; intestinal stem cell homeostasis; male genitalia development; metanephric glomerulus development; metanephric nephron tubule morphogenesis; negative regulation of cold-induced thermogenesis; negative regulation of cytokine production; negative regulation of DNA-templated transcription; negative regulation of toll-like receptor signaling pathway; osteoblast differentiation; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of canonical Wnt signaling pathway; positive regulation of DNA-templated transcription; rhythmic process; signal transduction; spermatogenesis; tube morphogenesis; Wnt signaling pathway","G protein-coupled receptor activity; protein binding; protein-hormone receptor activity; transmembrane signaling receptor activity","membrane; plasma membrane",null,"leucine rich repeat containing G protein-coupled receptor 4","http://www.ncbi.nlm.nih.gov/gene/?term=55366","55366","107515","286994",null,null,null,"Q9BXB1","A2ARI4","Q9Z2H4","A0A8P0SF16","A0A5G2QUC8","A0A1D5QCB5","GO:0016020; GO:0005886","GO:0004930; GO:0005515; GO:0016500; GO:0004888","GO:0030282; GO:0046849; GO:0061290; GO:0030154; GO:0072202; GO:0032922; GO:0007623; GO:0048565; GO:0050673; GO:2001013; GO:0007186; GO:0001942; GO:0002376; GO:0045087; GO:0036335; GO:0030539; GO:0072224; GO:0072282; GO:0120163; GO:0001818; GO:0045892; GO:0034122; GO:0001649; GO:0090190; GO:0090263; GO:0045893; GO:0048511; GO:0007165; GO:0007283; GO:0035239; GO:0016055","PTHR24372:SF67","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13299|UniProtKB=Q9BXB1"]
["LIMK1",null,"LIMK1","70","rb",null,2,2,8,8,2.1,2.1,"# 1311",".CCP., .CP., .CSP., .OP., .OPA., .OT., .RAS., .RTK., .ST., .UBI.","Cytoskeletal regulation by Rho GTPase","LIM DOMAIN KINASE 1","actin cytoskeleton organization; axon extension; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of ubiquitin-protein transferase activity; nervous system development; phosphorylation; positive regulation of actin filament bundle assembly; positive regulation of axon extension; positive regulation of stress fiber assembly; protein phosphorylation; Rho protein signal transduction; signal transduction; stress fiber assembly","ATP binding; heat shock protein binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cell projection; cytoplasm; cytoskeleton; cytosol; focal adhesion; intracellular organelle; lamellipodium; male germ cell nucleus; membrane; neuron projection; nuclear speck; nucleus",null,"LIM domain kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=3984","3984","16885",null,null,null,"699494","P53667","P53668","A0A0G2K4K5","A0A8I3MMK5","A0A287B488","H9ESB9","GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0043229; GO:0030027; GO:0001673; GO:0016020; GO:0043005; GO:0016607; GO:0005634","GO:0005524; GO:0031072; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0030036; GO:0048675; GO:0038096; GO:0051444; GO:0007399; GO:0016310; GO:0032233; GO:0045773; GO:0051496; GO:0006468; GO:0007266; GO:0007165; GO:0043149","PTHR46485:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6613|UniProtKB=P53667","P00016"]
["LIMK1/LIMK2 - phospho","Thr508(LIMK1)/Thr505(LIMK2)","LIMK1, LIMK2","72","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1309",".CCP., .CP., .CSP., .OP., .OPA., .OT., .RAS., .RTK., .ST., .UBI.","Cytoskeletal regulation by Rho GTPase","LIM DOMAIN KINASE 1; LIM DOMAIN KINASE 2","actin cytoskeleton organization; axon extension; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of ubiquitin-protein transferase activity; nervous system development; phosphorylation; positive regulation of actin filament bundle assembly; positive regulation of axon extension; positive regulation of stress fiber assembly; protein phosphorylation; Rho protein signal transduction; signal transduction; stress fiber assembly; astral microtubule organization; cornea development in camera-type eye; establishment of vesicle localization; head development; negative regulation of cilium assembly; positive regulation of protein localization to nucleus; positive regulation of protein phosphorylation; spermatogenesis","ATP binding; heat shock protein binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cell projection; cytoplasm; cytoskeleton; cytosol; focal adhesion; intracellular organelle; lamellipodium; male germ cell nucleus; membrane; neuron projection; nuclear speck; nucleus; centrosome; cis-Golgi network; microtubule organizing center; mitotic spindle; perinuclear region of cytoplasm; spindle",null,"LIM domain kinase 1; LIM domain kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=3984, http://www.ncbi.nlm.nih.gov/gene/?term=3985","3984, 3985","16885, 16886","NA, 29524",null,"NA, 100156359","699494, NA","P53667, P53671","P53668, O54785","A0A0G2K4K5, P53670","A0A8I3MMK5, A0A8I3PBK0","A0A287B488, A0A287B8P5","H9ESB9, A0A1D5QQX3","GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0043229; GO:0030027; GO:0001673; GO:0016020; GO:0043005; GO:0016607; GO:0005634; GO:0005813; GO:0005801; GO:0005815; GO:0072686; GO:0048471; GO:0005819","GO:0005524; GO:0031072; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0030036; GO:0048675; GO:0038096; GO:0051444; GO:0007399; GO:0016310; GO:0032233; GO:0045773; GO:0051496; GO:0006468; GO:0007266; GO:0007165; GO:0043149; GO:0030953; GO:0061303; GO:0051650; GO:0060322; GO:1902018; GO:1900182; GO:0001934; GO:0007283","PTHR46485:SF7; PTHR46485:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6613|UniProtKB=P53667; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6614|UniProtKB=P53671","P00016"]
["Lipoprotein lipase",null,"LPL","53","rb",null,1,1,8,8,8,8,"# 1397",".ALZ., .CSP., .DI., .DRR., .IMFR., .IMUR., .INS., .OP., .OPA., .OT., .SREME., .ST., .TRASR.","2-arachidonoylglycerol biosynthesis","LIPOPROTEIN LIPASE","cellular response to fatty acid; cellular response to nutrient; cholesterol homeostasis; chylomicron remodeling; fatty acid biosynthetic process; fatty acid metabolic process; lipid catabolic process; lipid metabolic process; low-density lipoprotein particle mediated signaling; negative regulation of cellular response to insulin stimulus; phospholipid metabolic process; positive regulation of chemokine (C-X-C motif) ligand 2 production; positive regulation of chemokine production; positive regulation of cholesterol storage; positive regulation of fat cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-1 beta production; positive regulation of interleukin-6 production; positive regulation of lipid storage; positive regulation of macrophage derived foam cell differentiation; positive regulation of sequestering of triglyceride; positive regulation of tumor necrosis factor production; response to bacterium; response to cold; response to glucose; response to xenobiotic stimulus; triglyceride biosynthetic process; triglyceride catabolic process; triglyceride homeostasis; triglyceride metabolic process; very-low-density lipoprotein particle remodeling","1-acyl-2-lysophosphatidylserine acylhydrolase activity; apolipoprotein binding; calcium ion binding; heparan sulfate proteoglycan binding; heparin binding; hydrolase activity; lipase activity; lipoprotein lipase activity; lipoprotein particle binding; metal ion binding; phosphatidylserine 1-acylhydrolase activity; phospholipase A1 activity; phospholipase activity; protein binding; protein homodimerization activity; protein-membrane adaptor activity; signaling receptor binding; triglyceride binding; triglyceride lipase activity","catalytic complex; cell surface; chylomicron; extracellular region; extracellular space; membrane; plasma membrane; very-low-density lipoprotein particle","Lipid metabolism","lipoprotein lipase","http://www.ncbi.nlm.nih.gov/gene/?term=4023","4023","16956",null,"403626",null,null,"P06858","P11152","A0A8L2Q8D2","A0A8I3Q1E8",null,"A0A5F7ZZH8","GO:1902494; GO:0009986; GO:0042627; GO:0005576; GO:0005615; GO:0016020; GO:0005886; GO:0034361","GO:0052740; GO:0034185; GO:0005509; GO:0043395; GO:0008201; GO:0016787; GO:0016298; GO:0004465; GO:0071813; GO:0046872; GO:0052739; GO:0008970; GO:0004620; GO:0005515; GO:0042803; GO:0043495; GO:0005102; GO:0017129; GO:0004806","GO:0071398; GO:0031670; GO:0042632; GO:0034371; GO:0006633; GO:0006631; GO:0016042; GO:0006629; GO:0055096; GO:1900077; GO:0006644; GO:2000343; GO:0032722; GO:0010886; GO:0045600; GO:0050729; GO:0032731; GO:0032755; GO:0010884; GO:0010744; GO:0010890; GO:0032760; GO:0009617; GO:0009409; GO:0009749; GO:0009410; GO:0019432; GO:0019433; GO:0070328; GO:0006641; GO:0034372","PTHR11610:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6677|UniProtKB=P06858","P05726"]
["LMO2 (Rhombotin-2)",null,"LMO2","18","rb",null,6,2,2.1,8,7,7,"# 1111",".OP., .OT., .TRASR.",null,"RHOMBOTIN-2","cellular response to thyroid hormone stimulus; positive regulation of transcription by RNA polymerase II","bHLH transcription factor binding; DNA-binding transcription factor binding; metal ion binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity; transcription coregulator binding","nucleoplasm; nucleus; transcription regulator complex",null,"LIM domain only 2","http://www.ncbi.nlm.nih.gov/gene/?term=4005","4005","16909",null,null,"100512825",null,"P25791","P25801","A0A0G2K3R4","A0A8I3PNN5","F1SGS5","F7AQI4","GO:0005654; GO:0005634; GO:0005667","GO:0043425; GO:0140297; GO:0046872; GO:0005515; GO:0061629; GO:0003713; GO:0001221","GO:0097067; GO:0045944","PTHR45787:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6642|UniProtKB=P25791"]
["LRP6",null,"LRP6","210, 180","rb",null,1,2.1,4,4,4,4,"# 0691",".ALZ., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CP., .CSP., .CUR., .D300., .DEV., .DI., .DMTOR., .MTOR., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.","Alzheimer disease-presenilin pathway; Wnt signaling pathway","LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6","canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in neural crest cell differentiation; canonical Wnt signaling pathway involved in regulation of cell proliferation; cell-cell adhesion; cellular response to cholesterol; chemical synaptic transmission; dopaminergic neuron differentiation; endocytosis; midbrain dopaminergic neuron differentiation; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest cell differentiation; neural crest formation; positive regulation of cell cycle; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; protein localization to plasma membrane; receptor-mediated endocytosis involved in cholesterol transport; regulation of DNA-templated transcription; response to peptide hormone; toxin transport; Wnt signaling pathway; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; Wnt signaling pathway involved in somitogenesis","coreceptor activity involved in canonical Wnt signaling pathway; coreceptor activity involved in Wnt signaling pathway; frizzled binding; identical protein binding; kinase inhibitor activity; low-density lipoprotein particle receptor activity; protein binding; protein homodimerization activity; signaling receptor binding; toxin transmembrane transporter activity; Wnt receptor activity; Wnt-protein binding","caveola; cell surface; cytoplasmic vesicle; early endosome; early endosome membrane; endoplasmic reticulum; extracellular region; Golgi apparatus; membrane; membrane raft; neuronal cell body; plasma membrane; synapse; Wnt signalosome; Wnt-Frizzled-LRP5/6 complex","Wnt signaling","LDL receptor related protein 6","http://www.ncbi.nlm.nih.gov/gene/?term=4040","4040",null,"312781",null,null,null,"O75581","A0A0N4SUL9","A0A0G2K0H3","A0A8I3PWF3","A0A287AAJ4","A0A5K1UTM6","GO:0005901; GO:0009986; GO:0031410; GO:0005769; GO:0031901; GO:0005783; GO:0005576; GO:0005794; GO:0016020; GO:0045121; GO:0043025; GO:0005886; GO:0045202; GO:1990909; GO:1990851","GO:1904928; GO:0071936; GO:0005109; GO:0042802; GO:0019210; GO:0005041; GO:0005515; GO:0042803; GO:0005102; GO:0019534; GO:0042813; GO:0017147","GO:0060070; GO:0044335; GO:0044340; GO:0098609; GO:0071397; GO:0007268; GO:0071542; GO:0006897; GO:1904948; GO:0006469; GO:0001933; GO:0071901; GO:0034392; GO:0014033; GO:0014029; GO:0045787; GO:0007204; GO:0051091; GO:0045893; GO:0045944; GO:0072659; GO:0090118; GO:0006355; GO:0043434; GO:1901998; GO:0016055; GO:1904953; GO:0090244","PTHR46513:SF40","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6698|UniProtKB=O75581","P00004; P00057"]
["LRP6 - phospho","Ser1490","LRP6","210, 180","rb",null,4,4,4,4,4,4,"# 1567",".ALZ., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CP., .CSP., .CUR., .D300., .DEV., .DI., .DMTOR., .MTOR., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.","Alzheimer disease-presenilin pathway; Wnt signaling pathway","LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6","canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in neural crest cell differentiation; canonical Wnt signaling pathway involved in regulation of cell proliferation; cell-cell adhesion; cellular response to cholesterol; chemical synaptic transmission; dopaminergic neuron differentiation; endocytosis; midbrain dopaminergic neuron differentiation; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest cell differentiation; neural crest formation; positive regulation of cell cycle; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; protein localization to plasma membrane; receptor-mediated endocytosis involved in cholesterol transport; regulation of DNA-templated transcription; response to peptide hormone; toxin transport; Wnt signaling pathway; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; Wnt signaling pathway involved in somitogenesis","coreceptor activity involved in canonical Wnt signaling pathway; coreceptor activity involved in Wnt signaling pathway; frizzled binding; identical protein binding; kinase inhibitor activity; low-density lipoprotein particle receptor activity; protein binding; protein homodimerization activity; signaling receptor binding; toxin transmembrane transporter activity; Wnt receptor activity; Wnt-protein binding","caveola; cell surface; cytoplasmic vesicle; early endosome; early endosome membrane; endoplasmic reticulum; extracellular region; Golgi apparatus; membrane; membrane raft; neuronal cell body; plasma membrane; synapse; Wnt signalosome; Wnt-Frizzled-LRP5/6 complex","Wnt signaling","LDL receptor related protein 6","http://www.ncbi.nlm.nih.gov/gene/?term=4040","4040",null,"312781",null,null,null,"O75581","A0A0N4SUL9","A0A0G2K0H3","A0A8I3PWF3","A0A287AAJ4","A0A5K1UTM6","GO:0005901; GO:0009986; GO:0031410; GO:0005769; GO:0031901; GO:0005783; GO:0005576; GO:0005794; GO:0016020; GO:0045121; GO:0043025; GO:0005886; GO:0045202; GO:1990909; GO:1990851","GO:1904928; GO:0071936; GO:0005109; GO:0042802; GO:0019210; GO:0005041; GO:0005515; GO:0042803; GO:0005102; GO:0019534; GO:0042813; GO:0017147","GO:0060070; GO:0044335; GO:0044340; GO:0098609; GO:0071397; GO:0007268; GO:0071542; GO:0006897; GO:1904948; GO:0006469; GO:0001933; GO:0071901; GO:0034392; GO:0014033; GO:0014029; GO:0045787; GO:0007204; GO:0051091; GO:0045893; GO:0045944; GO:0072659; GO:0090118; GO:0006355; GO:0043434; GO:1901998; GO:0016055; GO:1904953; GO:0090244","PTHR46513:SF40","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6698|UniProtKB=O75581","P00004; P00057"]
["LRRK2",null,"LRRK2","290","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1315",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .GPCR., .GPROT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR., .UBI., .WNT.",null,"LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 2","autophagy; calcium-mediated signaling; canonical Wnt signaling pathway; cell differentiation; cellular response to dopamine; cellular response to manganese ion; cellular response to organic cyclic compound; cellular response to oxidative stress; cellular response to starvation; determination of adult lifespan; endocytosis; endoplasmic reticulum organization; excitatory postsynaptic potential; exploration behavior; Golgi organization; GTP metabolic process; intracellular distribution of mitochondria; intracellular signal transduction; JNK cascade; locomotory exploration behavior; lysosome organization; MAPK cascade; mitochondrion localization; mitochondrion organization; negative regulation of autophagosome assembly; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of excitatory postsynaptic potential; negative regulation of GTPase activity; negative regulation of hydrogen peroxide-induced cell death; negative regulation of late endosome to lysosome transport; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of neuron projection development; negative regulation of peroxidase activity; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of protein processing; negative regulation of protein processing involved in protein targeting to mitochondrion; negative regulation of protein targeting to mitochondrion; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; neuromuscular junction development; neuron death; neuron projection arborization; neuron projection morphogenesis; olfactory bulb development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of canonical Wnt signaling pathway; positive regulation of dopamine receptor signaling pathway; positive regulation of histone deacetylase activity; positive regulation of MAP kinase activity; positive regulation of microglial cell activation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein autoubiquitination; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of synaptic vesicle endocytosis; positive regulation of tumor necrosis factor production; protein autophosphorylation; protein import into nucleus; protein localization; protein localization to endoplasmic reticulum exit site; protein localization to mitochondrion; protein phosphorylation; reactive oxygen species metabolic process; regulation of autophagy; regulation of branching morphogenesis of a nerve; regulation of CAMKK-AMPK signaling cascade; regulation of canonical Wnt signaling pathway; regulation of dendritic spine morphogenesis; regulation of dopamine receptor signaling pathway; regulation of ER to Golgi vesicle-mediated transport; regulation of gene expression; regulation of kidney size; regulation of locomotion; regulation of lysosomal lumen pH; regulation of membrane potential; regulation of mitochondrial depolarization; regulation of mitochondrial fission; regulation of neuroblast proliferation; regulation of neuron death; regulation of neuron maturation; regulation of protein kinase A signaling; regulation of protein stability; regulation of retrograde transport, endosome to Golgi; regulation of signal transduction; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle endocytosis; regulation of synaptic vesicle exocytosis; regulation of synaptic vesicle transport; response to oxidative stress; signal transduction; spermatogenesis; striatum development; tangential migration from the subventricular zone to the olfactory bulb; Wnt signalosome assembly","actin binding; ATP binding; beta-catenin destruction complex binding; clathrin binding; co-receptor binding; GTP binding; GTPase activator activity; GTPase activity; GTP-dependent protein kinase activity; hydrolase activity; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; microtubule binding; nucleotide binding; peroxidase inhibitor activity; protein binding; protein homodimerization activity; protein kinase A binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine phosphatase activity; signaling receptor complex adaptor activity; small GTPase binding; SNARE binding; syntaxin-1 binding; transferase activity; transmembrane transporter binding; tubulin binding","amphisome; autolysosome; axon; caveola neck; cell projection; cytoplasm; cytoplasmic side of mitochondrial outer membrane; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; endosome; extracellular exosome; extracellular space; glutamatergic synapse; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; growth cone; inclusion body; intracellular membrane-bounded organelle; lysosome; membrane; membrane raft; microvillus; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; multivesicular body, internal vesicle; neuron projection; neuronal cell body; perikaryon; plasma membrane; postsynapse; presynaptic cytosol; ribonucleoprotein complex; synapse; synaptic vesicle; synaptic vesicle membrane; terminal bouton; trans-Golgi network; Wnt signalosome",null,"leucine rich repeat kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=120892","120892","66725",null,"486608",null,null,"Q5S007","Q5S006","A0A8I6GFN0","A0A8I3QYS6","A0A8W4FN81","A0A1D5Q305","GO:0044753; GO:0044754; GO:0030424; GO:0099400; GO:0042995; GO:0005737; GO:0032473; GO:0031410; GO:0005829; GO:0030425; GO:0032839; GO:0005783; GO:0070971; GO:0005789; GO:0005768; GO:0070062; GO:0005615; GO:0098978; GO:0005794; GO:0000139; GO:0005798; GO:0030426; GO:0016234; GO:0043231; GO:0005764; GO:0016020; GO:0045121; GO:0005902; GO:0005743; GO:0005759; GO:0031966; GO:0005741; GO:0005739; GO:0097487; GO:0043005; GO:0043025; GO:0043204; GO:0005886; GO:0098794; GO:0099523; GO:1990904; GO:0045202; GO:0008021; GO:0030672; GO:0043195; GO:0005802; GO:1990909","GO:0003779; GO:0005524; GO:1904713; GO:0030276; GO:0039706; GO:0005525; GO:0005096; GO:0003924; GO:0034211; GO:0016787; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0008017; GO:0000166; GO:0036479; GO:0005515; GO:0042803; GO:0051018; GO:0004672; GO:0106310; GO:0004674; GO:0004722; GO:0030159; GO:0031267; GO:0000149; GO:0017075; GO:0016740; GO:0044325; GO:0015631","GO:0006914; GO:0019722; GO:0060070; GO:0030154; GO:1903351; GO:0071287; GO:0071407; GO:0034599; GO:0009267; GO:0008340; GO:0006897; GO:0007029; GO:0060079; GO:0035640; GO:0007030; GO:0046039; GO:0048312; GO:0035556; GO:0007254; GO:0035641; GO:0007040; GO:0000165; GO:0051646; GO:0007005; GO:1902902; GO:1902236; GO:0090394; GO:0034260; GO:1903206; GO:1902823; GO:0016242; GO:1901215; GO:0010977; GO:2000469; GO:0032091; GO:0001933; GO:0010955; GO:1903217; GO:1903215; GO:1903125; GO:0007528; GO:0070997; GO:0140058; GO:0048812; GO:0021772; GO:0018105; GO:0018107; GO:0016310; GO:0010508; GO:0090263; GO:0060161; GO:1901727; GO:0043406; GO:1903980; GO:0051770; GO:0043068; GO:0032436; GO:1902499; GO:0032092; GO:0045860; GO:0001934; GO:0031398; GO:1900244; GO:0032760; GO:0046777; GO:0006606; GO:0008104; GO:0070973; GO:0070585; GO:0006468; GO:0072593; GO:0010506; GO:2000172; GO:1905289; GO:0060828; GO:0061001; GO:0060159; GO:0060628; GO:0010468; GO:0035564; GO:0040012; GO:0035751; GO:0042391; GO:0051900; GO:0090140; GO:1902692; GO:1901214; GO:0014041; GO:0010738; GO:0031647; GO:1905279; GO:0009966; GO:0051966; GO:1900242; GO:2000300; GO:1902803; GO:0006979; GO:0007165; GO:0007283; GO:0021756; GO:0022028; GO:1904887","PTHR45752:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18618|UniProtKB=Q5S007"]
["LRRK2 - phospho","Ser910","LRRK2","286","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1342",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .GPCR., .GPROT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR., .UBI., .WNT.",null,"LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 2","autophagy; calcium-mediated signaling; canonical Wnt signaling pathway; cell differentiation; cellular response to dopamine; cellular response to manganese ion; cellular response to organic cyclic compound; cellular response to oxidative stress; cellular response to starvation; determination of adult lifespan; endocytosis; endoplasmic reticulum organization; excitatory postsynaptic potential; exploration behavior; Golgi organization; GTP metabolic process; intracellular distribution of mitochondria; intracellular signal transduction; JNK cascade; locomotory exploration behavior; lysosome organization; MAPK cascade; mitochondrion localization; mitochondrion organization; negative regulation of autophagosome assembly; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of excitatory postsynaptic potential; negative regulation of GTPase activity; negative regulation of hydrogen peroxide-induced cell death; negative regulation of late endosome to lysosome transport; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of neuron projection development; negative regulation of peroxidase activity; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of protein processing; negative regulation of protein processing involved in protein targeting to mitochondrion; negative regulation of protein targeting to mitochondrion; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; neuromuscular junction development; neuron death; neuron projection arborization; neuron projection morphogenesis; olfactory bulb development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of canonical Wnt signaling pathway; positive regulation of dopamine receptor signaling pathway; positive regulation of histone deacetylase activity; positive regulation of MAP kinase activity; positive regulation of microglial cell activation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein autoubiquitination; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of synaptic vesicle endocytosis; positive regulation of tumor necrosis factor production; protein autophosphorylation; protein import into nucleus; protein localization; protein localization to endoplasmic reticulum exit site; protein localization to mitochondrion; protein phosphorylation; reactive oxygen species metabolic process; regulation of autophagy; regulation of branching morphogenesis of a nerve; regulation of CAMKK-AMPK signaling cascade; regulation of canonical Wnt signaling pathway; regulation of dendritic spine morphogenesis; regulation of dopamine receptor signaling pathway; regulation of ER to Golgi vesicle-mediated transport; regulation of gene expression; regulation of kidney size; regulation of locomotion; regulation of lysosomal lumen pH; regulation of membrane potential; regulation of mitochondrial depolarization; regulation of mitochondrial fission; regulation of neuroblast proliferation; regulation of neuron death; regulation of neuron maturation; regulation of protein kinase A signaling; regulation of protein stability; regulation of retrograde transport, endosome to Golgi; regulation of signal transduction; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle endocytosis; regulation of synaptic vesicle exocytosis; regulation of synaptic vesicle transport; response to oxidative stress; signal transduction; spermatogenesis; striatum development; tangential migration from the subventricular zone to the olfactory bulb; Wnt signalosome assembly","actin binding; ATP binding; beta-catenin destruction complex binding; clathrin binding; co-receptor binding; GTP binding; GTPase activator activity; GTPase activity; GTP-dependent protein kinase activity; hydrolase activity; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; microtubule binding; nucleotide binding; peroxidase inhibitor activity; protein binding; protein homodimerization activity; protein kinase A binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine phosphatase activity; signaling receptor complex adaptor activity; small GTPase binding; SNARE binding; syntaxin-1 binding; transferase activity; transmembrane transporter binding; tubulin binding","amphisome; autolysosome; axon; caveola neck; cell projection; cytoplasm; cytoplasmic side of mitochondrial outer membrane; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; endosome; extracellular exosome; extracellular space; glutamatergic synapse; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; growth cone; inclusion body; intracellular membrane-bounded organelle; lysosome; membrane; membrane raft; microvillus; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; multivesicular body, internal vesicle; neuron projection; neuronal cell body; perikaryon; plasma membrane; postsynapse; presynaptic cytosol; ribonucleoprotein complex; synapse; synaptic vesicle; synaptic vesicle membrane; terminal bouton; trans-Golgi network; Wnt signalosome",null,"leucine rich repeat kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=120892","120892","66725",null,"486608",null,null,"Q5S007","Q5S006","A0A8I6GFN0","A0A8I3QYS6","A0A8W4FN81","A0A1D5Q305","GO:0044753; GO:0044754; GO:0030424; GO:0099400; GO:0042995; GO:0005737; GO:0032473; GO:0031410; GO:0005829; GO:0030425; GO:0032839; GO:0005783; GO:0070971; GO:0005789; GO:0005768; GO:0070062; GO:0005615; GO:0098978; GO:0005794; GO:0000139; GO:0005798; GO:0030426; GO:0016234; GO:0043231; GO:0005764; GO:0016020; GO:0045121; GO:0005902; GO:0005743; GO:0005759; GO:0031966; GO:0005741; GO:0005739; GO:0097487; GO:0043005; GO:0043025; GO:0043204; GO:0005886; GO:0098794; GO:0099523; GO:1990904; GO:0045202; GO:0008021; GO:0030672; GO:0043195; GO:0005802; GO:1990909","GO:0003779; GO:0005524; GO:1904713; GO:0030276; GO:0039706; GO:0005525; GO:0005096; GO:0003924; GO:0034211; GO:0016787; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0008017; GO:0000166; GO:0036479; GO:0005515; GO:0042803; GO:0051018; GO:0004672; GO:0106310; GO:0004674; GO:0004722; GO:0030159; GO:0031267; GO:0000149; GO:0017075; GO:0016740; GO:0044325; GO:0015631","GO:0006914; GO:0019722; GO:0060070; GO:0030154; GO:1903351; GO:0071287; GO:0071407; GO:0034599; GO:0009267; GO:0008340; GO:0006897; GO:0007029; GO:0060079; GO:0035640; GO:0007030; GO:0046039; GO:0048312; GO:0035556; GO:0007254; GO:0035641; GO:0007040; GO:0000165; GO:0051646; GO:0007005; GO:1902902; GO:1902236; GO:0090394; GO:0034260; GO:1903206; GO:1902823; GO:0016242; GO:1901215; GO:0010977; GO:2000469; GO:0032091; GO:0001933; GO:0010955; GO:1903217; GO:1903215; GO:1903125; GO:0007528; GO:0070997; GO:0140058; GO:0048812; GO:0021772; GO:0018105; GO:0018107; GO:0016310; GO:0010508; GO:0090263; GO:0060161; GO:1901727; GO:0043406; GO:1903980; GO:0051770; GO:0043068; GO:0032436; GO:1902499; GO:0032092; GO:0045860; GO:0001934; GO:0031398; GO:1900244; GO:0032760; GO:0046777; GO:0006606; GO:0008104; GO:0070973; GO:0070585; GO:0006468; GO:0072593; GO:0010506; GO:2000172; GO:1905289; GO:0060828; GO:0061001; GO:0060159; GO:0060628; GO:0010468; GO:0035564; GO:0040012; GO:0035751; GO:0042391; GO:0051900; GO:0090140; GO:1902692; GO:1901214; GO:0014041; GO:0010738; GO:0031647; GO:1905279; GO:0009966; GO:0051966; GO:1900242; GO:2000300; GO:1902803; GO:0006979; GO:0007165; GO:0007283; GO:0021756; GO:0022028; GO:1904887","PTHR45752:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18618|UniProtKB=Q5S007"]
["LRRK2 - phospho","Ser935","LRRK2","286","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1347",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .GPCR., .GPROT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR., .UBI., .WNT.",null,"LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 2","autophagy; calcium-mediated signaling; canonical Wnt signaling pathway; cell differentiation; cellular response to dopamine; cellular response to manganese ion; cellular response to organic cyclic compound; cellular response to oxidative stress; cellular response to starvation; determination of adult lifespan; endocytosis; endoplasmic reticulum organization; excitatory postsynaptic potential; exploration behavior; Golgi organization; GTP metabolic process; intracellular distribution of mitochondria; intracellular signal transduction; JNK cascade; locomotory exploration behavior; lysosome organization; MAPK cascade; mitochondrion localization; mitochondrion organization; negative regulation of autophagosome assembly; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of excitatory postsynaptic potential; negative regulation of GTPase activity; negative regulation of hydrogen peroxide-induced cell death; negative regulation of late endosome to lysosome transport; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of neuron projection development; negative regulation of peroxidase activity; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of protein processing; negative regulation of protein processing involved in protein targeting to mitochondrion; negative regulation of protein targeting to mitochondrion; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; neuromuscular junction development; neuron death; neuron projection arborization; neuron projection morphogenesis; olfactory bulb development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of canonical Wnt signaling pathway; positive regulation of dopamine receptor signaling pathway; positive regulation of histone deacetylase activity; positive regulation of MAP kinase activity; positive regulation of microglial cell activation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein autoubiquitination; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of synaptic vesicle endocytosis; positive regulation of tumor necrosis factor production; protein autophosphorylation; protein import into nucleus; protein localization; protein localization to endoplasmic reticulum exit site; protein localization to mitochondrion; protein phosphorylation; reactive oxygen species metabolic process; regulation of autophagy; regulation of branching morphogenesis of a nerve; regulation of CAMKK-AMPK signaling cascade; regulation of canonical Wnt signaling pathway; regulation of dendritic spine morphogenesis; regulation of dopamine receptor signaling pathway; regulation of ER to Golgi vesicle-mediated transport; regulation of gene expression; regulation of kidney size; regulation of locomotion; regulation of lysosomal lumen pH; regulation of membrane potential; regulation of mitochondrial depolarization; regulation of mitochondrial fission; regulation of neuroblast proliferation; regulation of neuron death; regulation of neuron maturation; regulation of protein kinase A signaling; regulation of protein stability; regulation of retrograde transport, endosome to Golgi; regulation of signal transduction; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle endocytosis; regulation of synaptic vesicle exocytosis; regulation of synaptic vesicle transport; response to oxidative stress; signal transduction; spermatogenesis; striatum development; tangential migration from the subventricular zone to the olfactory bulb; Wnt signalosome assembly","actin binding; ATP binding; beta-catenin destruction complex binding; clathrin binding; co-receptor binding; GTP binding; GTPase activator activity; GTPase activity; GTP-dependent protein kinase activity; hydrolase activity; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; microtubule binding; nucleotide binding; peroxidase inhibitor activity; protein binding; protein homodimerization activity; protein kinase A binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine phosphatase activity; signaling receptor complex adaptor activity; small GTPase binding; SNARE binding; syntaxin-1 binding; transferase activity; transmembrane transporter binding; tubulin binding","amphisome; autolysosome; axon; caveola neck; cell projection; cytoplasm; cytoplasmic side of mitochondrial outer membrane; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; endosome; extracellular exosome; extracellular space; glutamatergic synapse; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; growth cone; inclusion body; intracellular membrane-bounded organelle; lysosome; membrane; membrane raft; microvillus; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; multivesicular body, internal vesicle; neuron projection; neuronal cell body; perikaryon; plasma membrane; postsynapse; presynaptic cytosol; ribonucleoprotein complex; synapse; synaptic vesicle; synaptic vesicle membrane; terminal bouton; trans-Golgi network; Wnt signalosome",null,"leucine rich repeat kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=120892","120892","66725",null,"486608",null,null,"Q5S007","Q5S006","A0A8I6GFN0","A0A8I3QYS6","A0A8W4FN81","A0A1D5Q305","GO:0044753; GO:0044754; GO:0030424; GO:0099400; GO:0042995; GO:0005737; GO:0032473; GO:0031410; GO:0005829; GO:0030425; GO:0032839; GO:0005783; GO:0070971; GO:0005789; GO:0005768; GO:0070062; GO:0005615; GO:0098978; GO:0005794; GO:0000139; GO:0005798; GO:0030426; GO:0016234; GO:0043231; GO:0005764; GO:0016020; GO:0045121; GO:0005902; GO:0005743; GO:0005759; GO:0031966; GO:0005741; GO:0005739; GO:0097487; GO:0043005; GO:0043025; GO:0043204; GO:0005886; GO:0098794; GO:0099523; GO:1990904; GO:0045202; GO:0008021; GO:0030672; GO:0043195; GO:0005802; GO:1990909","GO:0003779; GO:0005524; GO:1904713; GO:0030276; GO:0039706; GO:0005525; GO:0005096; GO:0003924; GO:0034211; GO:0016787; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0008017; GO:0000166; GO:0036479; GO:0005515; GO:0042803; GO:0051018; GO:0004672; GO:0106310; GO:0004674; GO:0004722; GO:0030159; GO:0031267; GO:0000149; GO:0017075; GO:0016740; GO:0044325; GO:0015631","GO:0006914; GO:0019722; GO:0060070; GO:0030154; GO:1903351; GO:0071287; GO:0071407; GO:0034599; GO:0009267; GO:0008340; GO:0006897; GO:0007029; GO:0060079; GO:0035640; GO:0007030; GO:0046039; GO:0048312; GO:0035556; GO:0007254; GO:0035641; GO:0007040; GO:0000165; GO:0051646; GO:0007005; GO:1902902; GO:1902236; GO:0090394; GO:0034260; GO:1903206; GO:1902823; GO:0016242; GO:1901215; GO:0010977; GO:2000469; GO:0032091; GO:0001933; GO:0010955; GO:1903217; GO:1903215; GO:1903125; GO:0007528; GO:0070997; GO:0140058; GO:0048812; GO:0021772; GO:0018105; GO:0018107; GO:0016310; GO:0010508; GO:0090263; GO:0060161; GO:1901727; GO:0043406; GO:1903980; GO:0051770; GO:0043068; GO:0032436; GO:1902499; GO:0032092; GO:0045860; GO:0001934; GO:0031398; GO:1900244; GO:0032760; GO:0046777; GO:0006606; GO:0008104; GO:0070973; GO:0070585; GO:0006468; GO:0072593; GO:0010506; GO:2000172; GO:1905289; GO:0060828; GO:0061001; GO:0060159; GO:0060628; GO:0010468; GO:0035564; GO:0040012; GO:0035751; GO:0042391; GO:0051900; GO:0090140; GO:1902692; GO:1901214; GO:0014041; GO:0010738; GO:0031647; GO:1905279; GO:0009966; GO:0051966; GO:1900242; GO:2000300; GO:1902803; GO:0006979; GO:0007165; GO:0007283; GO:0021756; GO:0022028; GO:1904887","PTHR45752:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18618|UniProtKB=Q5S007"]
["LRRK2 - phospho","Thr1410","LRRK2","286","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1350",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .GPCR., .GPROT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR., .UBI., .WNT.",null,"LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 2","autophagy; calcium-mediated signaling; canonical Wnt signaling pathway; cell differentiation; cellular response to dopamine; cellular response to manganese ion; cellular response to organic cyclic compound; cellular response to oxidative stress; cellular response to starvation; determination of adult lifespan; endocytosis; endoplasmic reticulum organization; excitatory postsynaptic potential; exploration behavior; Golgi organization; GTP metabolic process; intracellular distribution of mitochondria; intracellular signal transduction; JNK cascade; locomotory exploration behavior; lysosome organization; MAPK cascade; mitochondrion localization; mitochondrion organization; negative regulation of autophagosome assembly; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of excitatory postsynaptic potential; negative regulation of GTPase activity; negative regulation of hydrogen peroxide-induced cell death; negative regulation of late endosome to lysosome transport; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of neuron projection development; negative regulation of peroxidase activity; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of protein processing; negative regulation of protein processing involved in protein targeting to mitochondrion; negative regulation of protein targeting to mitochondrion; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; neuromuscular junction development; neuron death; neuron projection arborization; neuron projection morphogenesis; olfactory bulb development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of canonical Wnt signaling pathway; positive regulation of dopamine receptor signaling pathway; positive regulation of histone deacetylase activity; positive regulation of MAP kinase activity; positive regulation of microglial cell activation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein autoubiquitination; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of synaptic vesicle endocytosis; positive regulation of tumor necrosis factor production; protein autophosphorylation; protein import into nucleus; protein localization; protein localization to endoplasmic reticulum exit site; protein localization to mitochondrion; protein phosphorylation; reactive oxygen species metabolic process; regulation of autophagy; regulation of branching morphogenesis of a nerve; regulation of CAMKK-AMPK signaling cascade; regulation of canonical Wnt signaling pathway; regulation of dendritic spine morphogenesis; regulation of dopamine receptor signaling pathway; regulation of ER to Golgi vesicle-mediated transport; regulation of gene expression; regulation of kidney size; regulation of locomotion; regulation of lysosomal lumen pH; regulation of membrane potential; regulation of mitochondrial depolarization; regulation of mitochondrial fission; regulation of neuroblast proliferation; regulation of neuron death; regulation of neuron maturation; regulation of protein kinase A signaling; regulation of protein stability; regulation of retrograde transport, endosome to Golgi; regulation of signal transduction; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle endocytosis; regulation of synaptic vesicle exocytosis; regulation of synaptic vesicle transport; response to oxidative stress; signal transduction; spermatogenesis; striatum development; tangential migration from the subventricular zone to the olfactory bulb; Wnt signalosome assembly","actin binding; ATP binding; beta-catenin destruction complex binding; clathrin binding; co-receptor binding; GTP binding; GTPase activator activity; GTPase activity; GTP-dependent protein kinase activity; hydrolase activity; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; microtubule binding; nucleotide binding; peroxidase inhibitor activity; protein binding; protein homodimerization activity; protein kinase A binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine phosphatase activity; signaling receptor complex adaptor activity; small GTPase binding; SNARE binding; syntaxin-1 binding; transferase activity; transmembrane transporter binding; tubulin binding","amphisome; autolysosome; axon; caveola neck; cell projection; cytoplasm; cytoplasmic side of mitochondrial outer membrane; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; endosome; extracellular exosome; extracellular space; glutamatergic synapse; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; growth cone; inclusion body; intracellular membrane-bounded organelle; lysosome; membrane; membrane raft; microvillus; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; multivesicular body, internal vesicle; neuron projection; neuronal cell body; perikaryon; plasma membrane; postsynapse; presynaptic cytosol; ribonucleoprotein complex; synapse; synaptic vesicle; synaptic vesicle membrane; terminal bouton; trans-Golgi network; Wnt signalosome",null,"leucine rich repeat kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=120892","120892","66725",null,"486608",null,null,"Q5S007","Q5S006","A0A8I6GFN0","A0A8I3QYS6","A0A8W4FN81","A0A1D5Q305","GO:0044753; GO:0044754; GO:0030424; GO:0099400; GO:0042995; GO:0005737; GO:0032473; GO:0031410; GO:0005829; GO:0030425; GO:0032839; GO:0005783; GO:0070971; GO:0005789; GO:0005768; GO:0070062; GO:0005615; GO:0098978; GO:0005794; GO:0000139; GO:0005798; GO:0030426; GO:0016234; GO:0043231; GO:0005764; GO:0016020; GO:0045121; GO:0005902; GO:0005743; GO:0005759; GO:0031966; GO:0005741; GO:0005739; GO:0097487; GO:0043005; GO:0043025; GO:0043204; GO:0005886; GO:0098794; GO:0099523; GO:1990904; GO:0045202; GO:0008021; GO:0030672; GO:0043195; GO:0005802; GO:1990909","GO:0003779; GO:0005524; GO:1904713; GO:0030276; GO:0039706; GO:0005525; GO:0005096; GO:0003924; GO:0034211; GO:0016787; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0008017; GO:0000166; GO:0036479; GO:0005515; GO:0042803; GO:0051018; GO:0004672; GO:0106310; GO:0004674; GO:0004722; GO:0030159; GO:0031267; GO:0000149; GO:0017075; GO:0016740; GO:0044325; GO:0015631","GO:0006914; GO:0019722; GO:0060070; GO:0030154; GO:1903351; GO:0071287; GO:0071407; GO:0034599; GO:0009267; GO:0008340; GO:0006897; GO:0007029; GO:0060079; GO:0035640; GO:0007030; GO:0046039; GO:0048312; GO:0035556; GO:0007254; GO:0035641; GO:0007040; GO:0000165; GO:0051646; GO:0007005; GO:1902902; GO:1902236; GO:0090394; GO:0034260; GO:1903206; GO:1902823; GO:0016242; GO:1901215; GO:0010977; GO:2000469; GO:0032091; GO:0001933; GO:0010955; GO:1903217; GO:1903215; GO:1903125; GO:0007528; GO:0070997; GO:0140058; GO:0048812; GO:0021772; GO:0018105; GO:0018107; GO:0016310; GO:0010508; GO:0090263; GO:0060161; GO:1901727; GO:0043406; GO:1903980; GO:0051770; GO:0043068; GO:0032436; GO:1902499; GO:0032092; GO:0045860; GO:0001934; GO:0031398; GO:1900244; GO:0032760; GO:0046777; GO:0006606; GO:0008104; GO:0070973; GO:0070585; GO:0006468; GO:0072593; GO:0010506; GO:2000172; GO:1905289; GO:0060828; GO:0061001; GO:0060159; GO:0060628; GO:0010468; GO:0035564; GO:0040012; GO:0035751; GO:0042391; GO:0051900; GO:0090140; GO:1902692; GO:1901214; GO:0014041; GO:0010738; GO:0031647; GO:1905279; GO:0009966; GO:0051966; GO:1900242; GO:2000300; GO:1902803; GO:0006979; GO:0007165; GO:0007283; GO:0021756; GO:0022028; GO:1904887","PTHR45752:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18618|UniProtKB=Q5S007"]
["LRRK2 - phospho","Thr1491","LRRK2","286","rb",null,4,7,"n/a","n/a","n/a","n/a","# 1351",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .GPCR., .GPROT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR., .UBI., .WNT.",null,"LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 2","autophagy; calcium-mediated signaling; canonical Wnt signaling pathway; cell differentiation; cellular response to dopamine; cellular response to manganese ion; cellular response to organic cyclic compound; cellular response to oxidative stress; cellular response to starvation; determination of adult lifespan; endocytosis; endoplasmic reticulum organization; excitatory postsynaptic potential; exploration behavior; Golgi organization; GTP metabolic process; intracellular distribution of mitochondria; intracellular signal transduction; JNK cascade; locomotory exploration behavior; lysosome organization; MAPK cascade; mitochondrion localization; mitochondrion organization; negative regulation of autophagosome assembly; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of excitatory postsynaptic potential; negative regulation of GTPase activity; negative regulation of hydrogen peroxide-induced cell death; negative regulation of late endosome to lysosome transport; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of neuron projection development; negative regulation of peroxidase activity; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of protein processing; negative regulation of protein processing involved in protein targeting to mitochondrion; negative regulation of protein targeting to mitochondrion; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; neuromuscular junction development; neuron death; neuron projection arborization; neuron projection morphogenesis; olfactory bulb development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of canonical Wnt signaling pathway; positive regulation of dopamine receptor signaling pathway; positive regulation of histone deacetylase activity; positive regulation of MAP kinase activity; positive regulation of microglial cell activation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein autoubiquitination; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of synaptic vesicle endocytosis; positive regulation of tumor necrosis factor production; protein autophosphorylation; protein import into nucleus; protein localization; protein localization to endoplasmic reticulum exit site; protein localization to mitochondrion; protein phosphorylation; reactive oxygen species metabolic process; regulation of autophagy; regulation of branching morphogenesis of a nerve; regulation of CAMKK-AMPK signaling cascade; regulation of canonical Wnt signaling pathway; regulation of dendritic spine morphogenesis; regulation of dopamine receptor signaling pathway; regulation of ER to Golgi vesicle-mediated transport; regulation of gene expression; regulation of kidney size; regulation of locomotion; regulation of lysosomal lumen pH; regulation of membrane potential; regulation of mitochondrial depolarization; regulation of mitochondrial fission; regulation of neuroblast proliferation; regulation of neuron death; regulation of neuron maturation; regulation of protein kinase A signaling; regulation of protein stability; regulation of retrograde transport, endosome to Golgi; regulation of signal transduction; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle endocytosis; regulation of synaptic vesicle exocytosis; regulation of synaptic vesicle transport; response to oxidative stress; signal transduction; spermatogenesis; striatum development; tangential migration from the subventricular zone to the olfactory bulb; Wnt signalosome assembly","actin binding; ATP binding; beta-catenin destruction complex binding; clathrin binding; co-receptor binding; GTP binding; GTPase activator activity; GTPase activity; GTP-dependent protein kinase activity; hydrolase activity; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; microtubule binding; nucleotide binding; peroxidase inhibitor activity; protein binding; protein homodimerization activity; protein kinase A binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine phosphatase activity; signaling receptor complex adaptor activity; small GTPase binding; SNARE binding; syntaxin-1 binding; transferase activity; transmembrane transporter binding; tubulin binding","amphisome; autolysosome; axon; caveola neck; cell projection; cytoplasm; cytoplasmic side of mitochondrial outer membrane; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; endosome; extracellular exosome; extracellular space; glutamatergic synapse; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; growth cone; inclusion body; intracellular membrane-bounded organelle; lysosome; membrane; membrane raft; microvillus; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; multivesicular body, internal vesicle; neuron projection; neuronal cell body; perikaryon; plasma membrane; postsynapse; presynaptic cytosol; ribonucleoprotein complex; synapse; synaptic vesicle; synaptic vesicle membrane; terminal bouton; trans-Golgi network; Wnt signalosome",null,"leucine rich repeat kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=120892","120892","66725",null,"486608",null,null,"Q5S007","Q5S006","A0A8I6GFN0","A0A8I3QYS6","A0A8W4FN81","A0A1D5Q305","GO:0044753; GO:0044754; GO:0030424; GO:0099400; GO:0042995; GO:0005737; GO:0032473; GO:0031410; GO:0005829; GO:0030425; GO:0032839; GO:0005783; GO:0070971; GO:0005789; GO:0005768; GO:0070062; GO:0005615; GO:0098978; GO:0005794; GO:0000139; GO:0005798; GO:0030426; GO:0016234; GO:0043231; GO:0005764; GO:0016020; GO:0045121; GO:0005902; GO:0005743; GO:0005759; GO:0031966; GO:0005741; GO:0005739; GO:0097487; GO:0043005; GO:0043025; GO:0043204; GO:0005886; GO:0098794; GO:0099523; GO:1990904; GO:0045202; GO:0008021; GO:0030672; GO:0043195; GO:0005802; GO:1990909","GO:0003779; GO:0005524; GO:1904713; GO:0030276; GO:0039706; GO:0005525; GO:0005096; GO:0003924; GO:0034211; GO:0016787; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0008017; GO:0000166; GO:0036479; GO:0005515; GO:0042803; GO:0051018; GO:0004672; GO:0106310; GO:0004674; GO:0004722; GO:0030159; GO:0031267; GO:0000149; GO:0017075; GO:0016740; GO:0044325; GO:0015631","GO:0006914; GO:0019722; GO:0060070; GO:0030154; GO:1903351; GO:0071287; GO:0071407; GO:0034599; GO:0009267; GO:0008340; GO:0006897; GO:0007029; GO:0060079; GO:0035640; GO:0007030; GO:0046039; GO:0048312; GO:0035556; GO:0007254; GO:0035641; GO:0007040; GO:0000165; GO:0051646; GO:0007005; GO:1902902; GO:1902236; GO:0090394; GO:0034260; GO:1903206; GO:1902823; GO:0016242; GO:1901215; GO:0010977; GO:2000469; GO:0032091; GO:0001933; GO:0010955; GO:1903217; GO:1903215; GO:1903125; GO:0007528; GO:0070997; GO:0140058; GO:0048812; GO:0021772; GO:0018105; GO:0018107; GO:0016310; GO:0010508; GO:0090263; GO:0060161; GO:1901727; GO:0043406; GO:1903980; GO:0051770; GO:0043068; GO:0032436; GO:1902499; GO:0032092; GO:0045860; GO:0001934; GO:0031398; GO:1900244; GO:0032760; GO:0046777; GO:0006606; GO:0008104; GO:0070973; GO:0070585; GO:0006468; GO:0072593; GO:0010506; GO:2000172; GO:1905289; GO:0060828; GO:0061001; GO:0060159; GO:0060628; GO:0010468; GO:0035564; GO:0040012; GO:0035751; GO:0042391; GO:0051900; GO:0090140; GO:1902692; GO:1901214; GO:0014041; GO:0010738; GO:0031647; GO:1905279; GO:0009966; GO:0051966; GO:1900242; GO:2000300; GO:1902803; GO:0006979; GO:0007165; GO:0007283; GO:0021756; GO:0022028; GO:1904887","PTHR45752:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18618|UniProtKB=Q5S007"]
["LRRK2 - phospho","Thr1503","LRRK2","286","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1345",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .GPCR., .GPROT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR., .UBI., .WNT.",null,"LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 2","autophagy; calcium-mediated signaling; canonical Wnt signaling pathway; cell differentiation; cellular response to dopamine; cellular response to manganese ion; cellular response to organic cyclic compound; cellular response to oxidative stress; cellular response to starvation; determination of adult lifespan; endocytosis; endoplasmic reticulum organization; excitatory postsynaptic potential; exploration behavior; Golgi organization; GTP metabolic process; intracellular distribution of mitochondria; intracellular signal transduction; JNK cascade; locomotory exploration behavior; lysosome organization; MAPK cascade; mitochondrion localization; mitochondrion organization; negative regulation of autophagosome assembly; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of excitatory postsynaptic potential; negative regulation of GTPase activity; negative regulation of hydrogen peroxide-induced cell death; negative regulation of late endosome to lysosome transport; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of neuron projection development; negative regulation of peroxidase activity; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of protein processing; negative regulation of protein processing involved in protein targeting to mitochondrion; negative regulation of protein targeting to mitochondrion; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; neuromuscular junction development; neuron death; neuron projection arborization; neuron projection morphogenesis; olfactory bulb development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of canonical Wnt signaling pathway; positive regulation of dopamine receptor signaling pathway; positive regulation of histone deacetylase activity; positive regulation of MAP kinase activity; positive regulation of microglial cell activation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein autoubiquitination; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of synaptic vesicle endocytosis; positive regulation of tumor necrosis factor production; protein autophosphorylation; protein import into nucleus; protein localization; protein localization to endoplasmic reticulum exit site; protein localization to mitochondrion; protein phosphorylation; reactive oxygen species metabolic process; regulation of autophagy; regulation of branching morphogenesis of a nerve; regulation of CAMKK-AMPK signaling cascade; regulation of canonical Wnt signaling pathway; regulation of dendritic spine morphogenesis; regulation of dopamine receptor signaling pathway; regulation of ER to Golgi vesicle-mediated transport; regulation of gene expression; regulation of kidney size; regulation of locomotion; regulation of lysosomal lumen pH; regulation of membrane potential; regulation of mitochondrial depolarization; regulation of mitochondrial fission; regulation of neuroblast proliferation; regulation of neuron death; regulation of neuron maturation; regulation of protein kinase A signaling; regulation of protein stability; regulation of retrograde transport, endosome to Golgi; regulation of signal transduction; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle endocytosis; regulation of synaptic vesicle exocytosis; regulation of synaptic vesicle transport; response to oxidative stress; signal transduction; spermatogenesis; striatum development; tangential migration from the subventricular zone to the olfactory bulb; Wnt signalosome assembly","actin binding; ATP binding; beta-catenin destruction complex binding; clathrin binding; co-receptor binding; GTP binding; GTPase activator activity; GTPase activity; GTP-dependent protein kinase activity; hydrolase activity; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; microtubule binding; nucleotide binding; peroxidase inhibitor activity; protein binding; protein homodimerization activity; protein kinase A binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine phosphatase activity; signaling receptor complex adaptor activity; small GTPase binding; SNARE binding; syntaxin-1 binding; transferase activity; transmembrane transporter binding; tubulin binding","amphisome; autolysosome; axon; caveola neck; cell projection; cytoplasm; cytoplasmic side of mitochondrial outer membrane; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; endosome; extracellular exosome; extracellular space; glutamatergic synapse; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; growth cone; inclusion body; intracellular membrane-bounded organelle; lysosome; membrane; membrane raft; microvillus; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; multivesicular body, internal vesicle; neuron projection; neuronal cell body; perikaryon; plasma membrane; postsynapse; presynaptic cytosol; ribonucleoprotein complex; synapse; synaptic vesicle; synaptic vesicle membrane; terminal bouton; trans-Golgi network; Wnt signalosome",null,"leucine rich repeat kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=120892","120892","66725",null,"486608",null,null,"Q5S007","Q5S006","A0A8I6GFN0","A0A8I3QYS6","A0A8W4FN81","A0A1D5Q305","GO:0044753; GO:0044754; GO:0030424; GO:0099400; GO:0042995; GO:0005737; GO:0032473; GO:0031410; GO:0005829; GO:0030425; GO:0032839; GO:0005783; GO:0070971; GO:0005789; GO:0005768; GO:0070062; GO:0005615; GO:0098978; GO:0005794; GO:0000139; GO:0005798; GO:0030426; GO:0016234; GO:0043231; GO:0005764; GO:0016020; GO:0045121; GO:0005902; GO:0005743; GO:0005759; GO:0031966; GO:0005741; GO:0005739; GO:0097487; GO:0043005; GO:0043025; GO:0043204; GO:0005886; GO:0098794; GO:0099523; GO:1990904; GO:0045202; GO:0008021; GO:0030672; GO:0043195; GO:0005802; GO:1990909","GO:0003779; GO:0005524; GO:1904713; GO:0030276; GO:0039706; GO:0005525; GO:0005096; GO:0003924; GO:0034211; GO:0016787; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0008017; GO:0000166; GO:0036479; GO:0005515; GO:0042803; GO:0051018; GO:0004672; GO:0106310; GO:0004674; GO:0004722; GO:0030159; GO:0031267; GO:0000149; GO:0017075; GO:0016740; GO:0044325; GO:0015631","GO:0006914; GO:0019722; GO:0060070; GO:0030154; GO:1903351; GO:0071287; GO:0071407; GO:0034599; GO:0009267; GO:0008340; GO:0006897; GO:0007029; GO:0060079; GO:0035640; GO:0007030; GO:0046039; GO:0048312; GO:0035556; GO:0007254; GO:0035641; GO:0007040; GO:0000165; GO:0051646; GO:0007005; GO:1902902; GO:1902236; GO:0090394; GO:0034260; GO:1903206; GO:1902823; GO:0016242; GO:1901215; GO:0010977; GO:2000469; GO:0032091; GO:0001933; GO:0010955; GO:1903217; GO:1903215; GO:1903125; GO:0007528; GO:0070997; GO:0140058; GO:0048812; GO:0021772; GO:0018105; GO:0018107; GO:0016310; GO:0010508; GO:0090263; GO:0060161; GO:1901727; GO:0043406; GO:1903980; GO:0051770; GO:0043068; GO:0032436; GO:1902499; GO:0032092; GO:0045860; GO:0001934; GO:0031398; GO:1900244; GO:0032760; GO:0046777; GO:0006606; GO:0008104; GO:0070973; GO:0070585; GO:0006468; GO:0072593; GO:0010506; GO:2000172; GO:1905289; GO:0060828; GO:0061001; GO:0060159; GO:0060628; GO:0010468; GO:0035564; GO:0040012; GO:0035751; GO:0042391; GO:0051900; GO:0090140; GO:1902692; GO:1901214; GO:0014041; GO:0010738; GO:0031647; GO:1905279; GO:0009966; GO:0051966; GO:1900242; GO:2000300; GO:1902803; GO:0006979; GO:0007165; GO:0007283; GO:0021756; GO:0022028; GO:1904887","PTHR45752:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18618|UniProtKB=Q5S007"]
["LRRK2 - phospho","Thr2483","LRRK2","286","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1349",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .GPCR., .GPROT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR., .UBI., .WNT.",null,"LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 2","autophagy; calcium-mediated signaling; canonical Wnt signaling pathway; cell differentiation; cellular response to dopamine; cellular response to manganese ion; cellular response to organic cyclic compound; cellular response to oxidative stress; cellular response to starvation; determination of adult lifespan; endocytosis; endoplasmic reticulum organization; excitatory postsynaptic potential; exploration behavior; Golgi organization; GTP metabolic process; intracellular distribution of mitochondria; intracellular signal transduction; JNK cascade; locomotory exploration behavior; lysosome organization; MAPK cascade; mitochondrion localization; mitochondrion organization; negative regulation of autophagosome assembly; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of excitatory postsynaptic potential; negative regulation of GTPase activity; negative regulation of hydrogen peroxide-induced cell death; negative regulation of late endosome to lysosome transport; negative regulation of macroautophagy; negative regulation of neuron death; negative regulation of neuron projection development; negative regulation of peroxidase activity; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of protein processing; negative regulation of protein processing involved in protein targeting to mitochondrion; negative regulation of protein targeting to mitochondrion; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation; neuromuscular junction development; neuron death; neuron projection arborization; neuron projection morphogenesis; olfactory bulb development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of canonical Wnt signaling pathway; positive regulation of dopamine receptor signaling pathway; positive regulation of histone deacetylase activity; positive regulation of MAP kinase activity; positive regulation of microglial cell activation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein autoubiquitination; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of synaptic vesicle endocytosis; positive regulation of tumor necrosis factor production; protein autophosphorylation; protein import into nucleus; protein localization; protein localization to endoplasmic reticulum exit site; protein localization to mitochondrion; protein phosphorylation; reactive oxygen species metabolic process; regulation of autophagy; regulation of branching morphogenesis of a nerve; regulation of CAMKK-AMPK signaling cascade; regulation of canonical Wnt signaling pathway; regulation of dendritic spine morphogenesis; regulation of dopamine receptor signaling pathway; regulation of ER to Golgi vesicle-mediated transport; regulation of gene expression; regulation of kidney size; regulation of locomotion; regulation of lysosomal lumen pH; regulation of membrane potential; regulation of mitochondrial depolarization; regulation of mitochondrial fission; regulation of neuroblast proliferation; regulation of neuron death; regulation of neuron maturation; regulation of protein kinase A signaling; regulation of protein stability; regulation of retrograde transport, endosome to Golgi; regulation of signal transduction; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle endocytosis; regulation of synaptic vesicle exocytosis; regulation of synaptic vesicle transport; response to oxidative stress; signal transduction; spermatogenesis; striatum development; tangential migration from the subventricular zone to the olfactory bulb; Wnt signalosome assembly","actin binding; ATP binding; beta-catenin destruction complex binding; clathrin binding; co-receptor binding; GTP binding; GTPase activator activity; GTPase activity; GTP-dependent protein kinase activity; hydrolase activity; identical protein binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; microtubule binding; nucleotide binding; peroxidase inhibitor activity; protein binding; protein homodimerization activity; protein kinase A binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine phosphatase activity; signaling receptor complex adaptor activity; small GTPase binding; SNARE binding; syntaxin-1 binding; transferase activity; transmembrane transporter binding; tubulin binding","amphisome; autolysosome; axon; caveola neck; cell projection; cytoplasm; cytoplasmic side of mitochondrial outer membrane; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; endosome; extracellular exosome; extracellular space; glutamatergic synapse; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; growth cone; inclusion body; intracellular membrane-bounded organelle; lysosome; membrane; membrane raft; microvillus; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; multivesicular body, internal vesicle; neuron projection; neuronal cell body; perikaryon; plasma membrane; postsynapse; presynaptic cytosol; ribonucleoprotein complex; synapse; synaptic vesicle; synaptic vesicle membrane; terminal bouton; trans-Golgi network; Wnt signalosome",null,"leucine rich repeat kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=120892","120892","66725",null,"486608",null,null,"Q5S007","Q5S006","A0A8I6GFN0","A0A8I3QYS6","A0A8W4FN81","A0A1D5Q305","GO:0044753; GO:0044754; GO:0030424; GO:0099400; GO:0042995; GO:0005737; GO:0032473; GO:0031410; GO:0005829; GO:0030425; GO:0032839; GO:0005783; GO:0070971; GO:0005789; GO:0005768; GO:0070062; GO:0005615; GO:0098978; GO:0005794; GO:0000139; GO:0005798; GO:0030426; GO:0016234; GO:0043231; GO:0005764; GO:0016020; GO:0045121; GO:0005902; GO:0005743; GO:0005759; GO:0031966; GO:0005741; GO:0005739; GO:0097487; GO:0043005; GO:0043025; GO:0043204; GO:0005886; GO:0098794; GO:0099523; GO:1990904; GO:0045202; GO:0008021; GO:0030672; GO:0043195; GO:0005802; GO:1990909","GO:0003779; GO:0005524; GO:1904713; GO:0030276; GO:0039706; GO:0005525; GO:0005096; GO:0003924; GO:0034211; GO:0016787; GO:0042802; GO:0004706; GO:0016301; GO:0000287; GO:0004709; GO:0008017; GO:0000166; GO:0036479; GO:0005515; GO:0042803; GO:0051018; GO:0004672; GO:0106310; GO:0004674; GO:0004722; GO:0030159; GO:0031267; GO:0000149; GO:0017075; GO:0016740; GO:0044325; GO:0015631","GO:0006914; GO:0019722; GO:0060070; GO:0030154; GO:1903351; GO:0071287; GO:0071407; GO:0034599; GO:0009267; GO:0008340; GO:0006897; GO:0007029; GO:0060079; GO:0035640; GO:0007030; GO:0046039; GO:0048312; GO:0035556; GO:0007254; GO:0035641; GO:0007040; GO:0000165; GO:0051646; GO:0007005; GO:1902902; GO:1902236; GO:0090394; GO:0034260; GO:1903206; GO:1902823; GO:0016242; GO:1901215; GO:0010977; GO:2000469; GO:0032091; GO:0001933; GO:0010955; GO:1903217; GO:1903215; GO:1903125; GO:0007528; GO:0070997; GO:0140058; GO:0048812; GO:0021772; GO:0018105; GO:0018107; GO:0016310; GO:0010508; GO:0090263; GO:0060161; GO:1901727; GO:0043406; GO:1903980; GO:0051770; GO:0043068; GO:0032436; GO:1902499; GO:0032092; GO:0045860; GO:0001934; GO:0031398; GO:1900244; GO:0032760; GO:0046777; GO:0006606; GO:0008104; GO:0070973; GO:0070585; GO:0006468; GO:0072593; GO:0010506; GO:2000172; GO:1905289; GO:0060828; GO:0061001; GO:0060159; GO:0060628; GO:0010468; GO:0035564; GO:0040012; GO:0035751; GO:0042391; GO:0051900; GO:0090140; GO:1902692; GO:1901214; GO:0014041; GO:0010738; GO:0031647; GO:1905279; GO:0009966; GO:0051966; GO:1900242; GO:2000300; GO:1902803; GO:0006979; GO:0007165; GO:0007283; GO:0021756; GO:0022028; GO:1904887","PTHR45752:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18618|UniProtKB=Q5S007"]
["LSD1",null,"KDM1A","110","rb",null,1,1,8.1,8,1,1,"# 1640",".APO., .cAMP., .CCP., .CD., .CP., .CSP., .DDR., .DREP., .GPCR., .OP., .OPA., .OT., .P53S., .ST., .TRASR., .UBI.",null,"LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A","alternative mRNA splicing, via spliceosome; cellular response to cAMP; cellular response to gamma radiation; cellular response to UV; cerebral cortex development; chromatin organization; DNA repair-dependent chromatin remodeling; guanine metabolic process; histone H3-K4 demethylation; histone modification; muscle cell development; negative regulation of DNA binding; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of histone H3-K4 methylation; negative regulation of histone H3-K9 methylation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein binding; negative regulation of transcription by RNA polymerase II; neuron maturation; positive regulation of cell size; positive regulation of chromatin binding; positive regulation of cold-induced thermogenesis; positive regulation of DNA-binding transcription factor activity; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron projection development; positive regulation of protein ubiquitination; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; protein demethylation; regulation of androgen receptor signaling pathway; regulation of DNA methylation-dependent heterochromatin formation; regulation of DNA-templated transcription; regulation of double-strand break repair via homologous recombination; regulation of protein localization; regulation of transcription by RNA polymerase II; response to fungicide; response to organic cyclic compound","chromatin binding; demethylase activity; DNA-binding transcription factor binding; enzyme binding; FAD-dependent H3K4me/H3K4me3 demethylase activity; flavin adenine dinucleotide binding; histone demethylase activity; histone H3K4 demethylase activity; histone H3K9 demethylase activity; MRF binding; nuclear androgen receptor binding; nuclear receptor coactivator activity; oxidoreductase activity; p53 binding; promoter-specific chromatin binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; telomeric DNA binding; telomeric repeat-containing RNA binding","chromatin; chromosome, telomeric region; DNA repair complex; nucleoplasm; nucleus; protein-containing complex; transcription regulator complex","Histone demethylase","lysine demethylase 1A","http://www.ncbi.nlm.nih.gov/gene/?term=23028","23028","99982",null,"478193",null,null,"O60341","Q6ZQ88","A0A0G2K736","A0A8I3MA21","A0A287A9K0","A0A1D5R152","GO:0000785; GO:0000781; GO:1990391; GO:0005654; GO:0005634; GO:0032991; GO:0005667","GO:0003682; GO:0032451; GO:0140297; GO:0019899; GO:0140682; GO:0050660; GO:0032452; GO:0032453; GO:0032454; GO:0043426; GO:0050681; GO:0030374; GO:0016491; GO:0002039; GO:1990841; GO:0005515; GO:0061629; GO:0042162; GO:0061752","GO:0000380; GO:0071320; GO:0071480; GO:0034644; GO:0021987; GO:0006325; GO:0140861; GO:0046098; GO:0034720; GO:0016570; GO:0055001; GO:0043392; GO:0043518; GO:0043433; GO:0045892; GO:0051572; GO:0051573; GO:1902166; GO:0032091; GO:0000122; GO:0042551; GO:0045793; GO:0035563; GO:0120162; GO:0051091; GO:2000179; GO:0002052; GO:0010976; GO:0031398; GO:2000648; GO:0045944; GO:0006482; GO:0060765; GO:0090308; GO:0006355; GO:0010569; GO:0032880; GO:0006357; GO:0060992; GO:0014070","PTHR10742:SF386","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=29079|UniProtKB=O60341"]
["MAD2L1",null,"MAD2L1","22","rb",null,1,1,"n/a","n/a","n/a","n/a","# 1878",".APO., .CCP., .CCY., .CD., .CP., .CSP., .OP., .OT., .UBI.",null,"MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A","cell cycle; cell division; establishment of centrosome localization; establishment of mitotic spindle orientation; mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; negative regulation of apoptotic process; negative regulation of mitotic cell cycle; negative regulation of protein catabolic process; negative regulation of ubiquitin protein ligase activity; negative regulation of ubiquitin-protein transferase activity; positive regulation of mitotic cell cycle spindle assembly checkpoint","identical protein binding; protein binding; protein C-terminus binding; protein homodimerization activity","chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; kinetochore; mitotic checkpoint complex; mitotic spindle; mitotic spindle assembly checkpoint MAD1-MAD2 complex; nuclear pore nuclear basket; nucleoplasm; nucleus; perinuclear region of cytoplasm; spindle pole",null,"mitotic arrest deficient 2 like 1","http://www.ncbi.nlm.nih.gov/gene/?term=4085","4085","56150","297176",null,null,null,"Q13257","Q9Z1B5","D4ACM2",null,null,"A0A1D5QZV0","GO:0005694; GO:0000775; GO:0005737; GO:0005856; GO:0005829; GO:0000776; GO:0033597; GO:0072686; GO:1990728; GO:0044615; GO:0005654; GO:0005634; GO:0048471; GO:0000922","GO:0042802; GO:0005515; GO:0008022; GO:0042803","GO:0007049; GO:0051301; GO:0051660; GO:0000132; GO:0000070; GO:0007094; GO:0043066; GO:0045930; GO:0042177; GO:1904667; GO:0051444; GO:0090267","PTHR11842:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6763|UniProtKB=Q13257"]
["MAFA",null,"MAFA","50","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2055",".OP., .OT., .TRASR.",null,"TRANSCRIPTION FACTOR MAFA","insulin secretion; nitric oxide mediated signal transduction; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to glucose","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; nucleus",null,"MAF bZIP transcription factor A","http://www.ncbi.nlm.nih.gov/gene/?term=389692","389692","378435","366949","100684427",null,null,"Q8NHW3","Q8CF90","D3ZNT6","A0A8I3NWP4",null,null,"GO:0000785; GO:0005634","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0000978; GO:1990837","GO:0030073; GO:0007263; GO:0045893; GO:0045944; GO:0006355; GO:0006357; GO:0009749","PTHR10129:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=23145|UniProtKB=Q8NHW3"]
["MAML1",null,"MAML1","130","rb",null,6,4,4,4,4,4,"# 1461",".CSP., .DEV., .NOTCH., .OP., .OPA., .OT., .ST., .TCD., .TMAT., .TRASR.","Notch signaling pathway","MASTERMIND-LIKE PROTEIN 1","atrioventricular node cell development; atrioventricular node development; myoblast differentiation; Notch signaling pathway; positive regulation of muscle cell differentiation; positive regulation of myotube differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of Notch receptor target; protein phosphorylation","peptide antigen binding; protein binding; protein kinase binding; transcription coactivator activity","intracellular membrane-bounded organelle; MAML1-RBP-Jkappa- ICN1 complex; nuclear speck; nucleoplasm; nucleus","Development","mastermind like transcriptional coactivator 1","http://www.ncbi.nlm.nih.gov/gene/?term=9794","9794","103806","303101",null,"100520231",null,"Q92585","Q6T264","D4A930","A0A8I3MXZ6","F1S442","A0A1D5RHB3","GO:0043231; GO:0002193; GO:0016607; GO:0005654; GO:0005634","GO:0042605; GO:0005515; GO:0019901; GO:0003713","GO:0060928; GO:0003162; GO:0045445; GO:0007219; GO:0051149; GO:0010831; GO:0045944; GO:0007221; GO:0006468","PTHR15692:SF19","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13632|UniProtKB=Q92585","P00045"]
["MAML2",null,"MAML2","160","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1537",".CSP., .DEV., .NOTCH., .OP., .OT., .TCD., .TMAT., .TRASR.",null,"MASTERMIND-LIKE PROTEIN 2","Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of Notch receptor target","protein binding; transcription coactivator activity","nuclear speck; nucleoplasm; nucleus","Development","mastermind like transcriptional coactivator 2","http://www.ncbi.nlm.nih.gov/gene/?term=84441","84441","270118","689844",null,null,null,"Q8IZL2","E9Q7L5","F1M3B2","A0A8I3NXM7",null,"F6W556","GO:0016607; GO:0005654; GO:0005634","GO:0005515; GO:0003713","GO:0007219; GO:0045944; GO:0007221","PTHR15692:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16259|UniProtKB=Q8IZL2"]
["MAP2-B",null,"MAP2","280","ms",null,7,4,"n/a","n/a","n/a","n/a","# 0520",".CCP., .CP., .OP.",null,"MICROTUBULE-ASSOCIATED PROTEIN 2","central nervous system neuron development; dendrite development; dendrite morphogenesis; microtubule cytoskeleton organization; negative regulation of axon extension; negative regulation of microtubule binding; negative regulation of microtubule polymerization; neuron projection development; positive regulation of anterograde dense core granule transport; positive regulation of anterograde synaptic vesicle transport; regulation of microtubule polymerization; regulation of organelle transport along microtubule; regulation of protein localization","calmodulin binding; dystroglycan binding; microtubule binding; protein binding; structural molecule activity; tau protein binding; tubulin binding","apical distal dendrite; axon hillock; axon initial segment; basal dendrite; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; dendrite cytoplasm; dendritic branch; dendritic filopodium; dendritic growth cone; dendritic shaft; distal dendrite; main axon; microtubule; microtubule associated complex; neuron projection; neuronal cell body; primary dendrite; proximal dendrite; proximal neuron projection","Neuronal signaling","microtubule associated protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=4133","4133","17756",null,null,"100153306","710840","P11137","P20357","A0A0U1RRQ0","A0A8I3PGT8","A0A286ZLW8","A0A1D5R639","GO:0150014; GO:0043203; GO:0043194; GO:0097441; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0032839; GO:0044307; GO:1902737; GO:0044294; GO:0043198; GO:0150002; GO:0044304; GO:0005874; GO:0005875; GO:0043005; GO:0043025; GO:0150001; GO:1990635; GO:1990769","GO:0005516; GO:0002162; GO:0008017; GO:0005515; GO:0005198; GO:0048156; GO:0015631","GO:0021954; GO:0016358; GO:0048813; GO:0000226; GO:0030517; GO:1904527; GO:0031115; GO:0031175; GO:1901953; GO:1903744; GO:0031113; GO:1902513; GO:0032880","PTHR11501:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6839|UniProtKB=P11137"]
["MAP4",null,"MAP4","220-200","ms",null,7,7,"n/a","n/a","n/a","n/a","# 0521",".CCP., .CP., .OP.",null,"MICROTUBULE-ASSOCIATED PROTEIN 4","cell division; establishment of spindle orientation; microtubule cytoskeleton organization; microtubule sliding; mitotic spindle organization; negative regulation of non-motile cilium assembly; neuron projection development","microtubule binding; protein binding; RNA binding; structural molecule activity; tubulin binding","axon; axoneme; cytoplasm; cytoskeleton; microtubule; microtubule associated complex; microtubule organizing center; mitotic spindle; neuron projection","Neuronal signaling","microtubule associated protein 4","http://www.ncbi.nlm.nih.gov/gene/?term=4134","4134","17758","367171",null,null,null,"P27816","P27546","A0A0G2JW88","A0A8P0NEQ4",null,"A0A5F7Z9K3","GO:0030424; GO:0005930; GO:0005737; GO:0005856; GO:0005874; GO:0005875; GO:0005815; GO:0072686; GO:0043005","GO:0008017; GO:0005515; GO:0003723; GO:0005198; GO:0015631","GO:0051301; GO:0051294; GO:0000226; GO:0051012; GO:0007052; GO:1902856; GO:0031175","PTHR11501:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6862|UniProtKB=P27816"]
["MAPK/CDK substrates - phospho","Thr","MAPK1, CDK1","n.a.","ms",null,2,4,"n/a","n/a","n/a","n/a","# 1609",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .UBI., .VEGFS., .VIR.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Apoptosis signaling pathway; p53 pathway","MITOGEN-ACTIVATED PROTEIN KINASE 1; CYCLIN-DEPENDENT KINASE 1","animal organ morphogenesis; apoptotic process; B cell receptor signaling pathway; Bergmann glial cell differentiation; cardiac neural crest cell development involved in heart development; caveolin-mediated endocytosis; cell cycle; cell surface receptor signaling pathway; cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to DNA damage stimulus; cellular response to dopamine; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; chemical synaptic transmission; chemotaxis; cytosine metabolic process; ERBB signaling pathway; ERK1 and ERK2 cascade; face development; heart development; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; intracellular signal transduction; labyrinthine layer blood vessel development; learning or memory; lipopolysaccharide-mediated signaling pathway; long-term synaptic potentiation; lung morphogenesis; mammary gland epithelial cell proliferation; MAPK cascade; negative regulation of cell differentiation; neural crest cell development; outer ear morphogenesis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of gene expression; positive regulation of macrophage chemotaxis; positive regulation of macrophage proliferation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein phosphorylation; regulation of cellular pH; regulation of cytoskeleton organization; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of ossification; regulation of protein stability; regulation of stress-activated MAPK cascade; response to chemical; response to epidermal growth factor; response to exogenous dsRNA; response to lipopolysaccharide; response to nicotine; signal transduction; stress-activated MAPK cascade; T cell receptor signaling pathway; thymus development; thyroid gland development; trachea formation; animal organ regeneration; cell division; cell migration; cellular response to hydrogen peroxide; cellular response to organic cyclic compound; centrosome cycle; chromosome condensation; DNA repair; DNA replication; epithelial cell differentiation; fibroblast proliferation; G2/M transition of mitotic cell cycle; Golgi disassembly; histone modification; microtubule cytoskeleton organization; mitotic cell cycle; mitotic cell cycle phase transition; mitotic G2 DNA damage checkpoint signaling; negative regulation of apoptotic process; negative regulation of gene expression; positive regulation of cardiac muscle cell proliferation; positive regulation of DNA replication; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; positive regulation of protein import into nucleus; positive regulation of protein localization to nucleus; pronuclear fusion; protein deubiquitination; protein localization to kinetochore; protein-containing complex assembly; regulation of circadian rhythm; regulation of embryonic development; regulation of Schwann cell differentiation; response to activity; response to amine; response to axon injury; response to cadmium ion; response to copper ion; response to ethanol; response to hydrogen peroxide; response to organic cyclic compound; response to organonitrogen compound; response to toxic substance; response to xenobiotic stimulus; rhythmic process; ventricular cardiac muscle cell development; viral entry into host cell","ATP binding; DNA binding; identical protein binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; nucleotide binding; phosphatase binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; histone kinase activity; Hsp70 protein binding; virus receptor activity","anchoring junction; azurophil granule lumen; caveola; cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum lumen; extracellular region; ficolin-1-rich granule lumen; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule organizing center; mitochondrion; mitotic spindle; nucleoplasm; nucleus; plasma membrane; pseudopodium; spindle; synapse; centrosome; chromosome, telomeric region; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex; endoplasmic reticulum membrane; extracellular exosome; midbody; mitochondrial matrix; spindle microtubule","MAPK signaling / cell cycle / checkpoint","mitogen-activated protein kinase 1; cyclin dependent kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5594, http://www.ncbi.nlm.nih.gov/gene/?term=983","5594, 983","26413, 12534","116590, 54237","477575, NA",null,"698569, NA","P28482, P06493","P63085, P11440","P63086, P39951","A0A8I3PZP0, A0A8I3MIX3","A0A286ZPF5, A0A287A6N5","F7ECR3, F7EBT6","GO:0070161; GO:0035578; GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005788; GO:0005576; GO:1904813; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005815; GO:0005739; GO:0072686; GO:0005654; GO:0005634; GO:0005886; GO:0031143; GO:0005819; GO:0045202; GO:0005813; GO:0000781; GO:0097125; GO:0000307; GO:0005789; GO:0070062; GO:0030496; GO:0005759; GO:0005876","GO:0005524; GO:0003677; GO:0042802; GO:0016301; GO:0004707; GO:0004708; GO:0000166; GO:0019902; GO:0001784; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0008353; GO:0016740; GO:0003682; GO:0030332; GO:0097472; GO:0004693; GO:0035173; GO:0030544; GO:0001618","GO:0009887; GO:0006915; GO:0050853; GO:0060020; GO:0061308; GO:0072584; GO:0007049; GO:0007166; GO:0034198; GO:0071276; GO:0006974; GO:1903351; GO:0034614; GO:0071356; GO:0007268; GO:0006935; GO:0019858; GO:0038127; GO:0070371; GO:0060324; GO:0007507; GO:0008286; GO:0048009; GO:0035556; GO:0060716; GO:0007611; GO:0031663; GO:0060291; GO:0060425; GO:0033598; GO:0000165; GO:0045596; GO:0014032; GO:0042473; GO:0018105; GO:0018107; GO:0016310; GO:0010628; GO:0010759; GO:0120041; GO:0010800; GO:0051973; GO:1904355; GO:0032212; GO:0006468; GO:0030641; GO:0051493; GO:2000641; GO:0090170; GO:0030278; GO:0031647; GO:0032872; GO:0042221; GO:0070849; GO:0043330; GO:0032496; GO:0035094; GO:0007165; GO:0051403; GO:0050852; GO:0048538; GO:0030878; GO:0060440; GO:0031100; GO:0051301; GO:0016477; GO:0070301; GO:0071407; GO:0007098; GO:0030261; GO:0006281; GO:0006260; GO:0030855; GO:0048144; GO:0000086; GO:0090166; GO:0016570; GO:0000226; GO:0000278; GO:0044772; GO:0007095; GO:0043066; GO:0010629; GO:0060045; GO:0045740; GO:0010971; GO:1905448; GO:0045931; GO:0042307; GO:1900182; GO:0007344; GO:0016579; GO:0034501; GO:0065003; GO:0042752; GO:0045995; GO:0014038; GO:0014823; GO:0014075; GO:0048678; GO:0046686; GO:0046688; GO:0045471; GO:0042542; GO:0014070; GO:0010243; GO:0009636; GO:0009410; GO:0048511; GO:0055015; GO:0046718","PTHR24055:SF569; PTHR24056:SF334","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6871|UniProtKB=P28482; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1722|UniProtKB=P06493","P06959; P00053; P00032; P00052; P00010; P00056; P00036; P06664; P00021; P04393; P00035; P00034; P00047; P05911; P00005; P00054; P00049; P00018; P00003; P00031; P00019; P00006; P00059"]
["MAPK15",null,"MAPK15","60","rb",null,2,7,7,7,2.1,4,"# 1560",".ALZ., .APH., .APO., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .DI., .EGFR., .ENDO., .FGFR., .IMUF., .INFG., .INFM., .INS., .INT., .MAPK., .MIG., .OP., .OPA., .OT., .PARK., .PDGF., .RTK., .SREME., .ST., .TGFB.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; TGF-beta signaling pathway; Interleukin signaling pathway; FGF signaling pathway; Interferon-gamma signaling pathway; PDGF signaling pathway; Parkinson disease; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE 15","cellular response to DNA damage stimulus; dopamine uptake; endoplasmic reticulum organization; intracellular signal transduction; MAPK cascade; negative regulation of cell migration; phosphorylation; positive regulation of cell population proliferation; positive regulation of metaphase/anaphase transition of meiosis I; positive regulation of spindle assembly; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein autophosphorylation; protein localization to ciliary transition zone; protein phosphorylation; regulation of autophagy; regulation of cilium assembly; regulation of COPII vesicle coating","ATP binding; chromatin binding; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; SH3 domain binding; transferase activity","anchoring junction; autophagosome; axoneme; bicellular tight junction; cell projection; cell-cell junction; centriole; ciliary basal body; cytoplasm; cytoplasmic vesicle; cytoskeleton; extracellular region; Golgi apparatus; meiotic spindle; nucleus; spindle","MAPK signaling","mitogen-activated protein kinase 15","http://www.ncbi.nlm.nih.gov/gene/?term=225689","225689","332110","286997","482080",null,"100428659","Q8TD08","Q80Y86","Q9Z2A6","A0A8I3NW66",null,"F6R8N9","GO:0070161; GO:0005776; GO:0005930; GO:0005923; GO:0042995; GO:0005911; GO:0005814; GO:0036064; GO:0005737; GO:0031410; GO:0005856; GO:0005576; GO:0005794; GO:0072687; GO:0005634; GO:0005819","GO:0005524; GO:0003682; GO:0016301; GO:0004707; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0017124; GO:0016740","GO:0006974; GO:0090494; GO:0007029; GO:0035556; GO:0000165; GO:0030336; GO:0016310; GO:0008284; GO:1905188; GO:1905832; GO:0051973; GO:1904355; GO:0032212; GO:0046777; GO:1904491; GO:0006468; GO:0010506; GO:1902017; GO:0003400","PTHR24055:SF79","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24667|UniProtKB=Q8TD08","P00032; P00052; P00036; P00021; P00035; P00047; P00049; P00018; P00003; P00031; P00019; P00006"]
["MAPKAPK-2",null,"MAPKAPK2","47","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1685",".ANG., .CANCER., .CD., .CSP., .DDR., .IMFR., .IMUR., .INT., .MAPK., .OP., .OPA., .OT., .P38., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS.","p38 MAPK pathway; VEGF signaling pathway; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway; Angiogenesis","MAP KINASE-ACTIVATED PROTEIN KINASE 2","3'-UTR-mediated mRNA stabilization; cellular response to DNA damage stimulus; cellular response to vascular endothelial growth factor stimulus; inflammatory response; inner ear development; intracellular signal transduction; leukotriene metabolic process; macropinocytosis; MAPK cascade; mRNA stabilization; p38MAPK cascade; peptidyl-serine phosphorylation; phosphorylation; positive regulation of macrophage cytokine production; positive regulation of tumor necrosis factor production; protein autophosphorylation; protein phosphorylation; regulation of cellular response to heat; regulation of interleukin-6 production; regulation of mRNA stability; regulation of tumor necrosis factor production; response to cytokine; response to lipopolysaccharide; response to stimulus; toll-like receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway","ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; kinase activity; mitogen-activated protein kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","centrosome; cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus",null,"MAPK activated protein kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=9261","9261","17164",null,null,null,"695044","P49137","P49138","A0A8I5ZZC5",null,"A0A8W4FES8","A0A1D5QDZ0","GO:0005813; GO:0005737; GO:0005829; GO:0070062; GO:0005654; GO:0005634","GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0016301; GO:0051019; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0070935; GO:0006974; GO:0035924; GO:0006954; GO:0048839; GO:0035556; GO:0006691; GO:0044351; GO:0000165; GO:0048255; GO:0038066; GO:0018105; GO:0016310; GO:0060907; GO:0032760; GO:0046777; GO:0006468; GO:1900034; GO:0032675; GO:0043488; GO:0032680; GO:0034097; GO:0032496; GO:0050896; GO:0002224; GO:0048010","PTHR24349:SF63","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6887|UniProtKB=P49137","P05918; P00056; P00036; P04393; P00047; P00005"]
["MAPKAPK-3",null,"MAPKAPK3","42","rb",null,1,1,"n/a","n/a","n/a","n/a","# 1693",".ANG., .CANCER., .CSP., .MAPK., .OP., .OPA., .P38., .RAS., .RTK., .SREME., .ST., .VEGFS.","p38 MAPK pathway; VEGF signaling pathway; Ras Pathway; Angiogenesis","MAP KINASE-ACTIVATED PROTEIN KINASE 3","intracellular signal transduction; macropinocytosis; MAPK cascade; peptidyl-serine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; response to cytokine; response to lipopolysaccharide; response to stimulus; signal transduction; toll-like receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway","ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus",null,"MAPK activated protein kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=7867","7867","102626","315994",null,null,null,"Q16644","Q3UMW7","Q66H84","A0A8I3S4A4","A0A5K1UJP6","A0A5F8AEA1","GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0016301; GO:0004708; GO:0051019; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0035556; GO:0044351; GO:0000165; GO:0018105; GO:0016310; GO:0046777; GO:0006468; GO:0034097; GO:0032496; GO:0050896; GO:0007165; GO:0002224; GO:0048010","PTHR24349:SF64","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6888|UniProtKB=Q16644","P05918; P00056; P04393; P00005"]
["MAPKAPK-5",null,"MAPKAPK5","58","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1694",".CD., .CSP., .MAPK., .MTOR., .OP., .OPA., .OT., .P53S., .RAS., .RTK., .ST., .TRASR.",null,"MAP KINASE-ACTIVATED PROTEIN KINASE 5","cellular senescence; intracellular signal transduction; MAPK cascade; negative regulation of TOR signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of dendritic spine development; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein autophosphorylation; protein phosphorylation; Ras protein signal transduction; regulation of signal transduction by p53 class mediator; regulation of translation; response to stimulus; signal transduction; stress-induced premature senescence","ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase binding; nucleotide binding; p53 binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex; septin cytoskeleton",null,"MAPK activated protein kinase 5","http://www.ncbi.nlm.nih.gov/gene/?term=8550","8550","17165","498183","477480",null,null,"Q8IW41","O54992","F1LN87","A0A8I3PAZ9","A0A5G2QAL3","F6ZBS3","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0032991; GO:0032156","GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0016301; GO:0004708; GO:0051019; GO:0000166; GO:0002039; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0090398; GO:0035556; GO:0000165; GO:0032007; GO:0018105; GO:0016310; GO:0060999; GO:0051973; GO:1904355; GO:0032212; GO:0046777; GO:0006468; GO:0007265; GO:1901796; GO:0006417; GO:0050896; GO:0007165; GO:0090400","PTHR24349:SF179","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6889|UniProtKB=Q8IW41"]
["MAVS",null,"MAVS","75, 52","rb",null,6,6,4,4,2,8,"# 0757",".CSP., .DI., .HEPB., .IIR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .NFKB., .OP., .OPA., .OT., .ST., .TRASR., .VIR.",null,"MITOCHONDRIAL ANTIVIRAL-SIGNALING PROTEIN","activation of innate immune response; antiviral innate immune response; cellular response to exogenous dsRNA; defense response to bacterium; defense response to virus; immune system process; innate immune response; negative regulation of viral genome replication; positive regulation of chemokine (C-C motif) ligand 5 production; positive regulation of defense response to virus by host; positive regulation of DNA-binding transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of IP-10 production; positive regulation of myeloid dendritic cell cytokine production; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein import into nucleus; positive regulation of protein phosphorylation; positive regulation of response to cytokine stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of type I interferon-mediated signaling pathway; protein localization to mitochondrion; regulation of peroxisome organization; response to stimulus; signal transduction; type I interferon-mediated signaling pathway","CARD domain binding; molecular condensate scaffold activity; protein binding; protein kinase binding; signaling adaptor activity","membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; peroxisomal membrane; peroxisome; ubiquitin ligase complex","NFkB signaling","mitochondrial antiviral signaling protein","http://www.ncbi.nlm.nih.gov/gene/?term=57506","57506","228607","311430","485789","100037290","717616","Q7Z434","Q8VCF0","Q66HG9","A0A8I3NTX2","A0A5K1V3V4","H9FXM3","GO:0016020; GO:0031966; GO:0005741; GO:0005739; GO:0005778; GO:0005777; GO:0000151","GO:0050700; GO:0140693; GO:0005515; GO:0019901; GO:0035591","GO:0002218; GO:0140374; GO:0071360; GO:0042742; GO:0051607; GO:0002376; GO:0045087; GO:0045071; GO:0071651; GO:0002230; GO:0051091; GO:0043123; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0071660; GO:0002735; GO:1900227; GO:0042307; GO:0001934; GO:0060760; GO:0045944; GO:0032760; GO:0060340; GO:0070585; GO:1900063; GO:0050896; GO:0007165; GO:0060337","PTHR21446:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=29233|UniProtKB=Q7Z434"]
["MBD3",null,"MBD3","34, 32, 28","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1632",".OP., .OT., .TRASR.",null,"METHYL-CPG-BINDING DOMAIN PROTEIN 3","aging; brain development; chromatin remodeling; DNA methylation-dependent heterochromatin formation; embryonic organ development; heart development; histone acetylation; histone deacetylation; in utero embryonic development; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; regulation of cell fate specification; regulation of DNA methylation; regulation of stem cell differentiation; response to estradiol; response to nutrient levels; response to organic cyclic compound; tissue development","chromatin binding; DNA binding; methyl-CpG binding; nucleosomal DNA binding; protein binding","chromatin; chromosome; cytoplasm; heterochromatin; nucleoplasm; nucleus; NuRD complex; protein-containing complex",null,"methyl-CpG binding domain protein 3","http://www.ncbi.nlm.nih.gov/gene/?term=53615","53615","17192",null,null,null,null,"O95983","Q9Z2D8","A0A8I6ANN7","A0A8I3NTS1","A0A5G2QKS4","A0A5F7ZJJ8","GO:0000785; GO:0005694; GO:0005737; GO:0000792; GO:0005654; GO:0005634; GO:0016581; GO:0032991","GO:0003682; GO:0003677; GO:0008327; GO:0031492; GO:0005515","GO:0007568; GO:0007420; GO:0006338; GO:0006346; GO:0048568; GO:0007507; GO:0016573; GO:0016575; GO:0001701; GO:0045892; GO:0000122; GO:0045893; GO:0042659; GO:0044030; GO:2000736; GO:0032355; GO:0031667; GO:0014070; GO:0009888","PTHR12396:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6918|UniProtKB=O95983"]
["MBD3",null,"MBD3","33","rb",null,2,6,6,2,2,2,"# 1639",".OP., .OT., .TRASR.",null,"METHYL-CPG-BINDING DOMAIN PROTEIN 3","aging; brain development; chromatin remodeling; DNA methylation-dependent heterochromatin formation; embryonic organ development; heart development; histone acetylation; histone deacetylation; in utero embryonic development; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; regulation of cell fate specification; regulation of DNA methylation; regulation of stem cell differentiation; response to estradiol; response to nutrient levels; response to organic cyclic compound; tissue development","chromatin binding; DNA binding; methyl-CpG binding; nucleosomal DNA binding; protein binding","chromatin; chromosome; cytoplasm; heterochromatin; nucleoplasm; nucleus; NuRD complex; protein-containing complex",null,"methyl-CpG binding domain protein 3","http://www.ncbi.nlm.nih.gov/gene/?term=53615","53615","17192",null,null,null,null,"O95983","Q9Z2D8","A0A8I6ANN7","A0A8I3NTS1","A0A5G2QKS4","A0A5F7ZJJ8","GO:0000785; GO:0005694; GO:0005737; GO:0000792; GO:0005654; GO:0005634; GO:0016581; GO:0032991","GO:0003682; GO:0003677; GO:0008327; GO:0031492; GO:0005515","GO:0007568; GO:0007420; GO:0006338; GO:0006346; GO:0048568; GO:0007507; GO:0016573; GO:0016575; GO:0001701; GO:0045892; GO:0000122; GO:0045893; GO:0042659; GO:0044030; GO:2000736; GO:0032355; GO:0031667; GO:0014070; GO:0009888","PTHR12396:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6918|UniProtKB=O95983"]
["Mcl-1",null,"MCL1","40, 35","rb",null,2,7,2.1,4,1.1000000000000001,4,"# 0702",".APH., .APO., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .OPA., .PI3K., .RTK., .ST., .STAT.","CCKR signaling map; Apoptosis signaling pathway","INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1","apoptotic process; cell differentiation; cell fate determination; cellular homeostasis; extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway; positive regulation of apoptotic process; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; protein transmembrane transport; regulation of apoptotic process; regulation of apoptotic signaling pathway; regulation of response to DNA damage stimulus; response to cytokine","BH3 domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein transmembrane transporter activity","Bcl-2 family protein complex; cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus","Apoptosis","MCL1 apoptosis regulator, BCL2 family member","http://www.ncbi.nlm.nih.gov/gene/?term=4170","4170","17210",null,"403537",null,null,"Q07820","P97287",null,"A0A8I3P430",null,null,"GO:0097136; GO:0005737; GO:0005829; GO:0016020; GO:0005741; GO:0005739; GO:0005654; GO:0005634","GO:0051434; GO:0005515; GO:0046982; GO:0042803; GO:0008320","GO:0006915; GO:0030154; GO:0001709; GO:0019725; GO:0097192; GO:0008630; GO:2000811; GO:0043066; GO:0010507; GO:2001240; GO:2001243; GO:0043065; GO:1903378; GO:0071806; GO:0042981; GO:2001233; GO:2001020; GO:0034097","PTHR11256:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6943|UniProtKB=Q07820","P06959; P00006"]
["Mcl-1 - phospho","Ser159/Thr163","MCL1","42","rb",null,1,1,8,8,8,8,"# 0698",".APH., .APO., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .OPA., .PI3K., .RTK., .ST., .STAT.","CCKR signaling map; Apoptosis signaling pathway","INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1","apoptotic process; cell differentiation; cell fate determination; cellular homeostasis; extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway; positive regulation of apoptotic process; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; protein transmembrane transport; regulation of apoptotic process; regulation of apoptotic signaling pathway; regulation of response to DNA damage stimulus; response to cytokine","BH3 domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein transmembrane transporter activity","Bcl-2 family protein complex; cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus","Apoptosis","MCL1 apoptosis regulator, BCL2 family member","http://www.ncbi.nlm.nih.gov/gene/?term=4170","4170","17210",null,"403537",null,null,"Q07820","P97287",null,"A0A8I3P430",null,null,"GO:0097136; GO:0005737; GO:0005829; GO:0016020; GO:0005741; GO:0005739; GO:0005654; GO:0005634","GO:0051434; GO:0005515; GO:0046982; GO:0042803; GO:0008320","GO:0006915; GO:0030154; GO:0001709; GO:0019725; GO:0097192; GO:0008630; GO:2000811; GO:0043066; GO:0010507; GO:2001240; GO:2001243; GO:0043065; GO:1903378; GO:0071806; GO:0042981; GO:2001233; GO:2001020; GO:0034097","PTHR11256:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6943|UniProtKB=Q07820","P06959; P00006"]
["MCM2",null,"MCM2","125","rb",null,1,1,1.1000000000000001,8,1.1000000000000001,2,"# 2125",".APO., .CCP., .CCY., .CD., .CSP., .DREP., .OP.",null,"DNA REPLICATION LICENSING FACTOR MCM2","apoptotic process; cell cycle; cellular response to interleukin-4; cochlea development; DNA duplex unwinding; DNA replication; DNA replication initiation; DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; mitotic DNA replication initiation; negative regulation of DNA helicase activity; nucleosome assembly; regulation of DNA-templated DNA replication initiation","3'-5' DNA helicase activity; ATP binding; ATP hydrolysis activity; DNA binding; DNA replication origin binding; enzyme binding; helicase activity; histone binding; hydrolase activity; metal ion binding; nucleotide binding; protein binding; single-stranded DNA binding; single-stranded DNA helicase activity","chromatin; chromosome; chromosome, telomeric region; CMG complex; cytoplasm; MCM complex; nuclear origin of replication recognition complex; nucleolus; nucleoplasm; nucleus","Cell cycle control","minichromosome maintenance complex component 2","http://www.ncbi.nlm.nih.gov/gene/?term=4171","4171","17216","312538",null,null,null,"P49736","P97310","D3ZP96","A0A8I3NR86","A0A287AD55","A0A5F8A4J0","GO:0000785; GO:0005694; GO:0000781; GO:0071162; GO:0005737; GO:0042555; GO:0005664; GO:0005730; GO:0005654; GO:0005634","GO:0043138; GO:0005524; GO:0016887; GO:0003677; GO:0003688; GO:0019899; GO:0004386; GO:0042393; GO:0016787; GO:0046872; GO:0000166; GO:0005515; GO:0003697; GO:0017116","GO:0006915; GO:0007049; GO:0071353; GO:0090102; GO:0032508; GO:0006260; GO:0006270; GO:0006268; GO:0000727; GO:1902975; GO:1905775; GO:0006334; GO:0030174","PTHR11630:SF44","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6944|UniProtKB=P49736"]
["MCM2 - phospho","Ser139","MCM2","125","rb",null,2,1,6,8,2.1,2.1,"# 1079",".APO., .CCP., .CCY., .CD., .CSP., .DREP., .OP.",null,"DNA REPLICATION LICENSING FACTOR MCM2","apoptotic process; cell cycle; cellular response to interleukin-4; cochlea development; DNA duplex unwinding; DNA replication; DNA replication initiation; DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; mitotic DNA replication initiation; negative regulation of DNA helicase activity; nucleosome assembly; regulation of DNA-templated DNA replication initiation","3'-5' DNA helicase activity; ATP binding; ATP hydrolysis activity; DNA binding; DNA replication origin binding; enzyme binding; helicase activity; histone binding; hydrolase activity; metal ion binding; nucleotide binding; protein binding; single-stranded DNA binding; single-stranded DNA helicase activity","chromatin; chromosome; chromosome, telomeric region; CMG complex; cytoplasm; MCM complex; nuclear origin of replication recognition complex; nucleolus; nucleoplasm; nucleus","Cell cycle control","minichromosome maintenance complex component 2","http://www.ncbi.nlm.nih.gov/gene/?term=4171","4171","17216","312538",null,null,null,"P49736","P97310","D3ZP96","A0A8I3NR86","A0A287AD55","A0A5F8A4J0","GO:0000785; GO:0005694; GO:0000781; GO:0071162; GO:0005737; GO:0042555; GO:0005664; GO:0005730; GO:0005654; GO:0005634","GO:0043138; GO:0005524; GO:0016887; GO:0003677; GO:0003688; GO:0019899; GO:0004386; GO:0042393; GO:0016787; GO:0046872; GO:0000166; GO:0005515; GO:0003697; GO:0017116","GO:0006915; GO:0007049; GO:0071353; GO:0090102; GO:0032508; GO:0006260; GO:0006270; GO:0006268; GO:0000727; GO:1902975; GO:1905775; GO:0006334; GO:0030174","PTHR11630:SF44","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6944|UniProtKB=P49736"]
["MDM2",null,"MDM2","90, 60","ms",null,1,4,1.1000000000000001,4,4,4,"# 1083",".APO., .BLC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DDR., .FOXO., .GLI., .HIF., .INS., .MEL., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SREME., .TRASR., .UBI.","p53 pathway; Insulin/IGF pathway-protein kinase B signaling cascade; P53 pathway feedback loops 1; Ubiquitin proteasome pathway; p53 pathway feedback loops 2","E3 UBIQUITIN-PROTEIN LIGASE MDM2","amyloid fibril formation; apoptotic process; atrial septum development; atrioventricular valve morphogenesis; blood vessel development; blood vessel remodeling; cardiac septum morphogenesis; cellular component organization; cellular response to actinomycin D; cellular response to gamma radiation; cellular response to hypoxia; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; endocardial cushion morphogenesis; establishment of protein localization; heart development; heart valve development; localization; negative regulation of apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of DNA-templated transcription; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of signal transduction by p53 class mediator; negative regulation of transcription by RNA polymerase II; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of mitotic cell cycle; positive regulation of muscle cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein destabilization; protein localization to nucleus; protein polyubiquitination; protein sumoylation; protein ubiquitination; protein-containing complex assembly; proteolysis involved in protein catabolic process; regulation of biological quality; regulation of cell cycle; regulation of gene expression; regulation of heart rate; regulation of protein catabolic process; regulation of transcription by RNA polymerase II; response to antibiotic; transcription factor catabolic process; traversing start control point of mitotic cell cycle; ubiquitin-dependent protein catabolic process; ventricular septum development","5S rRNA binding; disordered domain specific binding; enzyme binding; identical protein binding; ligase activity; metal ion binding; NEDD8 ligase activity; p53 binding; protein binding; protein domain specific binding; protein N-terminus binding; ribonucleoprotein complex binding; SUMO transferase activity; transferase activity; ubiquitin binding; ubiquitin protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding","cytoplasm; cytosol; endocytic vesicle membrane; nuclear body; nucleolus; nucleoplasm; nucleus; plasma membrane; protein-containing complex; transcription repressor complex","Cell cycle control / oncogene","MDM2 proto-oncogene","http://www.ncbi.nlm.nih.gov/gene/?term=4193","4193","17246","314856","403693","100125959",null,"Q00987","P23804","A0A0G2JVC1","P56950","A0A286ZIP0",null,"GO:0005737; GO:0005829; GO:0030666; GO:0016604; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0017053","GO:0008097; GO:0097718; GO:0019899; GO:0042802; GO:0016874; GO:0046872; GO:0061663; GO:0002039; GO:0005515; GO:0019904; GO:0047485; GO:0043021; GO:0019789; GO:0016740; GO:0043130; GO:0061630; GO:0031625; GO:0004842; GO:0008270","GO:1990000; GO:0006915; GO:0003283; GO:0003181; GO:0001568; GO:0001974; GO:0060411; GO:0016043; GO:0072717; GO:0071480; GO:0071456; GO:0006977; GO:0003203; GO:0045184; GO:0007507; GO:0003170; GO:0051179; GO:0043066; GO:0043518; GO:0045892; GO:1902254; GO:1901797; GO:0000122; GO:0045787; GO:0008284; GO:0045931; GO:0051149; GO:0032436; GO:0043161; GO:0051865; GO:0031648; GO:0034504; GO:0000209; GO:0016925; GO:0016567; GO:0065003; GO:0051603; GO:0065008; GO:0051726; GO:0010468; GO:0002027; GO:0042176; GO:0006357; GO:0046677; GO:0036369; GO:0007089; GO:0006511; GO:0003281","PTHR46858:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6973|UniProtKB=Q00987","P00059; P00033; P04392; P00060; P04398"]
["MDM2 - phospho","Ser166","MDM2","90","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2400",".APO., .BLC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .FOXO., .GLI., .HIF., .INS., .MEL., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SREME., .TRASR., .UBI.","p53 pathway; Insulin/IGF pathway-protein kinase B signaling cascade; P53 pathway feedback loops 1; Ubiquitin proteasome pathway; p53 pathway feedback loops 2","E3 UBIQUITIN-PROTEIN LIGASE MDM2","amyloid fibril formation; apoptotic process; atrial septum development; atrioventricular valve morphogenesis; blood vessel development; blood vessel remodeling; cardiac septum morphogenesis; cellular component organization; cellular response to actinomycin D; cellular response to gamma radiation; cellular response to hypoxia; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; endocardial cushion morphogenesis; establishment of protein localization; heart development; heart valve development; localization; negative regulation of apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of DNA-templated transcription; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of signal transduction by p53 class mediator; negative regulation of transcription by RNA polymerase II; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of mitotic cell cycle; positive regulation of muscle cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein destabilization; protein localization to nucleus; protein polyubiquitination; protein sumoylation; protein ubiquitination; protein-containing complex assembly; proteolysis involved in protein catabolic process; regulation of biological quality; regulation of cell cycle; regulation of gene expression; regulation of heart rate; regulation of protein catabolic process; regulation of transcription by RNA polymerase II; response to antibiotic; transcription factor catabolic process; traversing start control point of mitotic cell cycle; ubiquitin-dependent protein catabolic process; ventricular septum development","5S rRNA binding; disordered domain specific binding; enzyme binding; identical protein binding; ligase activity; metal ion binding; NEDD8 ligase activity; p53 binding; protein binding; protein domain specific binding; protein N-terminus binding; ribonucleoprotein complex binding; SUMO transferase activity; transferase activity; ubiquitin binding; ubiquitin protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding","cytoplasm; cytosol; endocytic vesicle membrane; nuclear body; nucleolus; nucleoplasm; nucleus; plasma membrane; protein-containing complex; transcription repressor complex","Cell cycle control / oncogene","MDM2 proto-oncogene","http://www.ncbi.nlm.nih.gov/gene/?term=4193","4193","17246","314856","403693","100125959",null,"Q00987","P23804","A0A0G2JVC1","P56950","A0A286ZIP0",null,"GO:0005737; GO:0005829; GO:0030666; GO:0016604; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0017053","GO:0008097; GO:0097718; GO:0019899; GO:0042802; GO:0016874; GO:0046872; GO:0061663; GO:0002039; GO:0005515; GO:0019904; GO:0047485; GO:0043021; GO:0019789; GO:0016740; GO:0043130; GO:0061630; GO:0031625; GO:0004842; GO:0008270","GO:1990000; GO:0006915; GO:0003283; GO:0003181; GO:0001568; GO:0001974; GO:0060411; GO:0016043; GO:0072717; GO:0071480; GO:0071456; GO:0006977; GO:0003203; GO:0045184; GO:0007507; GO:0003170; GO:0051179; GO:0043066; GO:0043518; GO:0045892; GO:1902254; GO:1901797; GO:0000122; GO:0045787; GO:0008284; GO:0045931; GO:0051149; GO:0032436; GO:0043161; GO:0051865; GO:0031648; GO:0034504; GO:0000209; GO:0016925; GO:0016567; GO:0065003; GO:0051603; GO:0065008; GO:0051726; GO:0010468; GO:0002027; GO:0042176; GO:0006357; GO:0046677; GO:0036369; GO:0007089; GO:0006511; GO:0003281","PTHR46858:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6973|UniProtKB=Q00987","P00059; P00033; P04392; P00060; P04398"]
["MDM2 - phospho","Ser166","MDM2","90","rb",null,7,4,4,4,4,4,"# 1773",".APO., .BLC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .DDR., .FOXO., .GLI., .HIF., .INS., .MEL., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SREME., .TRASR., .UBI.","p53 pathway; Insulin/IGF pathway-protein kinase B signaling cascade; P53 pathway feedback loops 1; Ubiquitin proteasome pathway; p53 pathway feedback loops 2","E3 UBIQUITIN-PROTEIN LIGASE MDM2","amyloid fibril formation; apoptotic process; atrial septum development; atrioventricular valve morphogenesis; blood vessel development; blood vessel remodeling; cardiac septum morphogenesis; cellular component organization; cellular response to actinomycin D; cellular response to gamma radiation; cellular response to hypoxia; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; endocardial cushion morphogenesis; establishment of protein localization; heart development; heart valve development; localization; negative regulation of apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of DNA-templated transcription; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of signal transduction by p53 class mediator; negative regulation of transcription by RNA polymerase II; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of mitotic cell cycle; positive regulation of muscle cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein destabilization; protein localization to nucleus; protein polyubiquitination; protein sumoylation; protein ubiquitination; protein-containing complex assembly; proteolysis involved in protein catabolic process; regulation of biological quality; regulation of cell cycle; regulation of gene expression; regulation of heart rate; regulation of protein catabolic process; regulation of transcription by RNA polymerase II; response to antibiotic; transcription factor catabolic process; traversing start control point of mitotic cell cycle; ubiquitin-dependent protein catabolic process; ventricular septum development","5S rRNA binding; disordered domain specific binding; enzyme binding; identical protein binding; ligase activity; metal ion binding; NEDD8 ligase activity; p53 binding; protein binding; protein domain specific binding; protein N-terminus binding; ribonucleoprotein complex binding; SUMO transferase activity; transferase activity; ubiquitin binding; ubiquitin protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding","cytoplasm; cytosol; endocytic vesicle membrane; nuclear body; nucleolus; nucleoplasm; nucleus; plasma membrane; protein-containing complex; transcription repressor complex","Cell cycle control / oncogene","MDM2 proto-oncogene","http://www.ncbi.nlm.nih.gov/gene/?term=4193","4193","17246","314856","403693","100125959",null,"Q00987","P23804","A0A0G2JVC1","P56950","A0A286ZIP0",null,"GO:0005737; GO:0005829; GO:0030666; GO:0016604; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0017053","GO:0008097; GO:0097718; GO:0019899; GO:0042802; GO:0016874; GO:0046872; GO:0061663; GO:0002039; GO:0005515; GO:0019904; GO:0047485; GO:0043021; GO:0019789; GO:0016740; GO:0043130; GO:0061630; GO:0031625; GO:0004842; GO:0008270","GO:1990000; GO:0006915; GO:0003283; GO:0003181; GO:0001568; GO:0001974; GO:0060411; GO:0016043; GO:0072717; GO:0071480; GO:0071456; GO:0006977; GO:0003203; GO:0045184; GO:0007507; GO:0003170; GO:0051179; GO:0043066; GO:0043518; GO:0045892; GO:1902254; GO:1901797; GO:0000122; GO:0045787; GO:0008284; GO:0045931; GO:0051149; GO:0032436; GO:0043161; GO:0051865; GO:0031648; GO:0034504; GO:0000209; GO:0016925; GO:0016567; GO:0065003; GO:0051603; GO:0065008; GO:0051726; GO:0010468; GO:0002027; GO:0042176; GO:0006357; GO:0046677; GO:0036369; GO:0007089; GO:0006511; GO:0003281","PTHR46858:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6973|UniProtKB=Q00987","P00059; P00033; P04392; P00060; P04398"]
["MEK1",null,"MAP2K1","45","rb",null,2,2,6,6,6,6,"# 2477",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; EGF receptor signaling pathway; Endothelin signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Bergmann glial cell differentiation; cell motility; cellular senescence; cerebellar cortex formation; chemotaxis; endodermal cell differentiation; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; insulin-like growth factor receptor signaling pathway; keratinocyte differentiation; labyrinthine layer development; lung morphogenesis; MAPK cascade; negative regulation of cell population proliferation; neuron differentiation; peptidyl-tyrosine phosphorylation; phosphorylation; placenta blood vessel development; positive regulation of axonogenesis; positive regulation of DNA-templated transcription; positive regulation of endodermal cell differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development; trachea formation; type B pancreatic cell proliferation","ATP binding; kinase activity; MAP kinase kinase activity; MAP-kinase scaffold activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activator activity; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity","cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule organizing center; mitochondrion; nucleus; plasma membrane","MAPK signaling","mitogen-activated protein kinase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5604","5604","26395",null,null,null,null,"Q02750","P31938","A0A0H2UHI2","A0A8I3NMM5",null,"A0A1D5R0Y1","GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005783; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005815; GO:0005739; GO:0005634; GO:0005886","GO:0005524; GO:0016301; GO:0004708; GO:0005078; GO:0000166; GO:0005515; GO:0008022; GO:0030295; GO:0004672; GO:0047485; GO:0106310; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0016740","GO:0060020; GO:0048870; GO:0090398; GO:0021697; GO:0006935; GO:0035987; GO:0060502; GO:0070371; GO:0060324; GO:0007507; GO:0048009; GO:0030216; GO:0060711; GO:0060425; GO:0000165; GO:0008285; GO:0030182; GO:0018108; GO:0016310; GO:0060674; GO:0050772; GO:0045893; GO:1903226; GO:0070374; GO:0010628; GO:0043410; GO:0071902; GO:0006468; GO:0048679; GO:2000641; GO:0090170; GO:0032872; GO:0007165; GO:0048538; GO:0030878; GO:0060440; GO:0044342","PTHR48013:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6840|UniProtKB=Q02750","P06959; P00053; P00032; P00010; P00056; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00054; P00018; P00019"]
["MEK1 - phospho","Ser298","MAP2K1","45","rb",null,1,1,"n/a","n/a","n/a","n/a","# 3125",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; EGF receptor signaling pathway; Endothelin signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Bergmann glial cell differentiation; cell motility; cellular senescence; cerebellar cortex formation; chemotaxis; endodermal cell differentiation; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; insulin-like growth factor receptor signaling pathway; keratinocyte differentiation; labyrinthine layer development; lung morphogenesis; MAPK cascade; negative regulation of cell population proliferation; neuron differentiation; peptidyl-tyrosine phosphorylation; phosphorylation; placenta blood vessel development; positive regulation of axonogenesis; positive regulation of DNA-templated transcription; positive regulation of endodermal cell differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development; trachea formation; type B pancreatic cell proliferation","ATP binding; kinase activity; MAP kinase kinase activity; MAP-kinase scaffold activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activator activity; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity","cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule organizing center; mitochondrion; nucleus; plasma membrane",null,"mitogen-activated protein kinase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5604","5604","26395",null,null,null,null,"Q02750","P31938","A0A0H2UHI2","A0A8I3NMM5",null,"A0A1D5R0Y1","GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005783; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005815; GO:0005739; GO:0005634; GO:0005886","GO:0005524; GO:0016301; GO:0004708; GO:0005078; GO:0000166; GO:0005515; GO:0008022; GO:0030295; GO:0004672; GO:0047485; GO:0106310; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0016740","GO:0060020; GO:0048870; GO:0090398; GO:0021697; GO:0006935; GO:0035987; GO:0060502; GO:0070371; GO:0060324; GO:0007507; GO:0048009; GO:0030216; GO:0060711; GO:0060425; GO:0000165; GO:0008285; GO:0030182; GO:0018108; GO:0016310; GO:0060674; GO:0050772; GO:0045893; GO:1903226; GO:0070374; GO:0010628; GO:0043410; GO:0071902; GO:0006468; GO:0048679; GO:2000641; GO:0090170; GO:0032872; GO:0007165; GO:0048538; GO:0030878; GO:0060440; GO:0044342","PTHR48013:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6840|UniProtKB=Q02750","P06959; P00053; P00032; P00010; P00056; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00054; P00018; P00019"]
["MEK1 - phospho","Thr286","MAP2K1","45","rb",null,7,4,4,4,4,4,"# 0210",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .DI., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; EGF receptor signaling pathway; Endothelin signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Bergmann glial cell differentiation; cell motility; cellular senescence; cerebellar cortex formation; chemotaxis; endodermal cell differentiation; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; insulin-like growth factor receptor signaling pathway; keratinocyte differentiation; labyrinthine layer development; lung morphogenesis; MAPK cascade; negative regulation of cell population proliferation; neuron differentiation; peptidyl-tyrosine phosphorylation; phosphorylation; placenta blood vessel development; positive regulation of axonogenesis; positive regulation of DNA-templated transcription; positive regulation of endodermal cell differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development; trachea formation; type B pancreatic cell proliferation","ATP binding; kinase activity; MAP kinase kinase activity; MAP-kinase scaffold activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activator activity; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity","cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule organizing center; mitochondrion; nucleus; plasma membrane","MAPK signaling","mitogen-activated protein kinase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5604","5604","26395",null,null,null,null,"Q02750","P31938","A0A0H2UHI2","A0A8I3NMM5",null,"A0A1D5R0Y1","GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005783; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005815; GO:0005739; GO:0005634; GO:0005886","GO:0005524; GO:0016301; GO:0004708; GO:0005078; GO:0000166; GO:0005515; GO:0008022; GO:0030295; GO:0004672; GO:0047485; GO:0106310; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0016740","GO:0060020; GO:0048870; GO:0090398; GO:0021697; GO:0006935; GO:0035987; GO:0060502; GO:0070371; GO:0060324; GO:0007507; GO:0048009; GO:0030216; GO:0060711; GO:0060425; GO:0000165; GO:0008285; GO:0030182; GO:0018108; GO:0016310; GO:0060674; GO:0050772; GO:0045893; GO:1903226; GO:0070374; GO:0010628; GO:0043410; GO:0071902; GO:0006468; GO:0048679; GO:2000641; GO:0090170; GO:0032872; GO:0007165; GO:0048538; GO:0030878; GO:0060440; GO:0044342","PTHR48013:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6840|UniProtKB=Q02750","P06959; P00053; P00032; P00010; P00056; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00054; P00018; P00019"]
["MEK1 - phospho","Thr286","MAP2K1","45","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2370",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; EGF receptor signaling pathway; Endothelin signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Bergmann glial cell differentiation; cell motility; cellular senescence; cerebellar cortex formation; chemotaxis; endodermal cell differentiation; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; insulin-like growth factor receptor signaling pathway; keratinocyte differentiation; labyrinthine layer development; lung morphogenesis; MAPK cascade; negative regulation of cell population proliferation; neuron differentiation; peptidyl-tyrosine phosphorylation; phosphorylation; placenta blood vessel development; positive regulation of axonogenesis; positive regulation of DNA-templated transcription; positive regulation of endodermal cell differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development; trachea formation; type B pancreatic cell proliferation","ATP binding; kinase activity; MAP kinase kinase activity; MAP-kinase scaffold activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activator activity; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity","cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule organizing center; mitochondrion; nucleus; plasma membrane","MAPK signaling","mitogen-activated protein kinase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5604","5604","26395",null,null,null,null,"Q02750","P31938","A0A0H2UHI2","A0A8I3NMM5",null,"A0A1D5R0Y1","GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005783; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005815; GO:0005739; GO:0005634; GO:0005886","GO:0005524; GO:0016301; GO:0004708; GO:0005078; GO:0000166; GO:0005515; GO:0008022; GO:0030295; GO:0004672; GO:0047485; GO:0106310; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0016740","GO:0060020; GO:0048870; GO:0090398; GO:0021697; GO:0006935; GO:0035987; GO:0060502; GO:0070371; GO:0060324; GO:0007507; GO:0048009; GO:0030216; GO:0060711; GO:0060425; GO:0000165; GO:0008285; GO:0030182; GO:0018108; GO:0016310; GO:0060674; GO:0050772; GO:0045893; GO:1903226; GO:0070374; GO:0010628; GO:0043410; GO:0071902; GO:0006468; GO:0048679; GO:2000641; GO:0090170; GO:0032872; GO:0007165; GO:0048538; GO:0030878; GO:0060440; GO:0044342","PTHR48013:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6840|UniProtKB=Q02750","P06959; P00053; P00032; P00010; P00056; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00054; P00018; P00019"]
["MEK1 - phospho","Thr292","MAP2K1","45","rb",null,6.1,1,8,8,8,8,"# 1721",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .DI., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; EGF receptor signaling pathway; Endothelin signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Bergmann glial cell differentiation; cell motility; cellular senescence; cerebellar cortex formation; chemotaxis; endodermal cell differentiation; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; insulin-like growth factor receptor signaling pathway; keratinocyte differentiation; labyrinthine layer development; lung morphogenesis; MAPK cascade; negative regulation of cell population proliferation; neuron differentiation; peptidyl-tyrosine phosphorylation; phosphorylation; placenta blood vessel development; positive regulation of axonogenesis; positive regulation of DNA-templated transcription; positive regulation of endodermal cell differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development; trachea formation; type B pancreatic cell proliferation","ATP binding; kinase activity; MAP kinase kinase activity; MAP-kinase scaffold activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activator activity; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity","cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule organizing center; mitochondrion; nucleus; plasma membrane","MAPK signaling","mitogen-activated protein kinase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5604","5604","26395",null,null,null,null,"Q02750","P31938","A0A0H2UHI2","A0A8I3NMM5",null,"A0A1D5R0Y1","GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005783; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005815; GO:0005739; GO:0005634; GO:0005886","GO:0005524; GO:0016301; GO:0004708; GO:0005078; GO:0000166; GO:0005515; GO:0008022; GO:0030295; GO:0004672; GO:0047485; GO:0106310; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0016740","GO:0060020; GO:0048870; GO:0090398; GO:0021697; GO:0006935; GO:0035987; GO:0060502; GO:0070371; GO:0060324; GO:0007507; GO:0048009; GO:0030216; GO:0060711; GO:0060425; GO:0000165; GO:0008285; GO:0030182; GO:0018108; GO:0016310; GO:0060674; GO:0050772; GO:0045893; GO:1903226; GO:0070374; GO:0010628; GO:0043410; GO:0071902; GO:0006468; GO:0048679; GO:2000641; GO:0090170; GO:0032872; GO:0007165; GO:0048538; GO:0030878; GO:0060440; GO:0044342","PTHR48013:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6840|UniProtKB=Q02750","P06959; P00053; P00032; P00010; P00056; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00054; P00018; P00019"]
["MEK1 - phospho","Thr292","MAP2K1","45","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2371",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; EGF receptor signaling pathway; Endothelin signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Bergmann glial cell differentiation; cell motility; cellular senescence; cerebellar cortex formation; chemotaxis; endodermal cell differentiation; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; insulin-like growth factor receptor signaling pathway; keratinocyte differentiation; labyrinthine layer development; lung morphogenesis; MAPK cascade; negative regulation of cell population proliferation; neuron differentiation; peptidyl-tyrosine phosphorylation; phosphorylation; placenta blood vessel development; positive regulation of axonogenesis; positive regulation of DNA-templated transcription; positive regulation of endodermal cell differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development; trachea formation; type B pancreatic cell proliferation","ATP binding; kinase activity; MAP kinase kinase activity; MAP-kinase scaffold activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activator activity; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity","cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule organizing center; mitochondrion; nucleus; plasma membrane","MAPK signaling","mitogen-activated protein kinase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5604","5604","26395",null,null,null,null,"Q02750","P31938","A0A0H2UHI2","A0A8I3NMM5",null,"A0A1D5R0Y1","GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005783; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005815; GO:0005739; GO:0005634; GO:0005886","GO:0005524; GO:0016301; GO:0004708; GO:0005078; GO:0000166; GO:0005515; GO:0008022; GO:0030295; GO:0004672; GO:0047485; GO:0106310; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0016740","GO:0060020; GO:0048870; GO:0090398; GO:0021697; GO:0006935; GO:0035987; GO:0060502; GO:0070371; GO:0060324; GO:0007507; GO:0048009; GO:0030216; GO:0060711; GO:0060425; GO:0000165; GO:0008285; GO:0030182; GO:0018108; GO:0016310; GO:0060674; GO:0050772; GO:0045893; GO:1903226; GO:0070374; GO:0010628; GO:0043410; GO:0071902; GO:0006468; GO:0048679; GO:2000641; GO:0090170; GO:0032872; GO:0007165; GO:0048538; GO:0030878; GO:0060440; GO:0044342","PTHR48013:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6840|UniProtKB=Q02750","P06959; P00053; P00032; P00010; P00056; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00054; P00018; P00019"]
["MEK1/2 - phospho","Ser217/Ser221","MAP2K1, MAP2K2","45","rb",null,2,1,8,8,8,8,"# 3126",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; EGF receptor signaling pathway; Endothelin signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1; DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2","Bergmann glial cell differentiation; cell motility; cellular senescence; cerebellar cortex formation; chemotaxis; endodermal cell differentiation; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; insulin-like growth factor receptor signaling pathway; keratinocyte differentiation; labyrinthine layer development; lung morphogenesis; MAPK cascade; negative regulation of cell population proliferation; neuron differentiation; peptidyl-tyrosine phosphorylation; phosphorylation; placenta blood vessel development; positive regulation of axonogenesis; positive regulation of DNA-templated transcription; positive regulation of endodermal cell differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development; trachea formation; type B pancreatic cell proliferation; peptidyl-serine autophosphorylation; positive regulation of cell motility","ATP binding; kinase activity; MAP kinase kinase activity; MAP-kinase scaffold activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activator activity; protein kinase activity; protein N-terminus binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity; metal ion binding; molecular adaptor activity; PDZ domain binding","cytoplasm; cytoskeleton; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule organizing center; mitochondrion; nucleus; plasma membrane; cell-cell junction; cytoplasmic side of plasma membrane; extracellular region; microtubule; perinuclear region of cytoplasm; peroxisomal membrane","MAPK signaling","mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5604, http://www.ncbi.nlm.nih.gov/gene/?term=5605","5604, 5605","26395, 26396",null,"NA, 611939","",null,"Q02750, P36507","P31938, Q63932","A0A0H2UHI2, A0A8I5ZPN3","A0A8I3NMM5, Q1HG70","A0A5G2QEB7","A0A1D5R0Y1, A0A1D5QW55","GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0005783; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005815; GO:0005739; GO:0005634; GO:0005886; GO:0005911; GO:0009898; GO:0005576; GO:0005874; GO:0048471; GO:0005778","GO:0005524; GO:0016301; GO:0004708; GO:0005078; GO:0000166; GO:0005515; GO:0008022; GO:0030295; GO:0004672; GO:0047485; GO:0106310; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0016740; GO:0046872; GO:0060090; GO:0030165","GO:0060020; GO:0048870; GO:0090398; GO:0021697; GO:0006935; GO:0035987; GO:0060502; GO:0070371; GO:0060324; GO:0007507; GO:0048009; GO:0030216; GO:0060711; GO:0060425; GO:0000165; GO:0008285; GO:0030182; GO:0018108; GO:0016310; GO:0060674; GO:0050772; GO:0045893; GO:1903226; GO:0070374; GO:0010628; GO:0043410; GO:0071902; GO:0006468; GO:0048679; GO:2000641; GO:0090170; GO:0032872; GO:0007165; GO:0048538; GO:0030878; GO:0060440; GO:0044342; GO:0036289; GO:2000147","PTHR48013:SF5; PTHR48013:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6840|UniProtKB=Q02750; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6842|UniProtKB=P36507","P06959; P00053; P00032; P00010; P00056; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00054; P00018; P00019"]
["MEK2",null,"MAP2K2","45","rb",null,2,2,8,8,1,1.1000000000000001,"# 1789",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TOLL., .TRASR., .TYR., .VEGFS.","CCKR signaling map; T cell activation; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; Toll receptor signaling pathway; EGF receptor signaling pathway; Endothelin signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2","epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; insulin-like growth factor receptor signaling pathway; lung morphogenesis; MAPK cascade; peptidyl-serine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of axonogenesis; positive regulation of cell motility; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; thymus development; thyroid gland development; trachea formation","ATP binding; kinase activity; MAP kinase kinase activity; MAP-kinase scaffold activity; metal ion binding; molecular adaptor activity; nucleotide binding; PDZ domain binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity","cell-cell junction; cytoplasm; cytoplasmic side of plasma membrane; cytosol; early endosome; endoplasmic reticulum; extracellular region; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm; peroxisomal membrane",null,"mitogen-activated protein kinase kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5605","5605","26396",null,"611939",null,null,"P36507","Q63932","A0A8I5ZPN3","Q1HG70","A0A5G2QEB7","A0A1D5QW55","GO:0005911; GO:0005737; GO:0009898; GO:0005829; GO:0005769; GO:0005783; GO:0005576; GO:0005925; GO:0005794; GO:0005770; GO:0016020; GO:0005874; GO:0005739; GO:0005634; GO:0048471; GO:0005778","GO:0005524; GO:0016301; GO:0004708; GO:0005078; GO:0046872; GO:0060090; GO:0000166; GO:0030165; GO:0005515; GO:0004672; GO:0106310; GO:0043539; GO:0004674; GO:0004712; GO:0004713; GO:0097110; GO:0016740","GO:0060502; GO:0070371; GO:0060324; GO:0007507; GO:0048009; GO:0060425; GO:0000165; GO:0036289; GO:0018108; GO:0016310; GO:0050772; GO:2000147; GO:0045893; GO:0010628; GO:0043410; GO:0071902; GO:0006468; GO:0048679; GO:2000641; GO:0090170; GO:0032872; GO:0048538; GO:0030878; GO:0060440","PTHR48013:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6842|UniProtKB=P36507","P06959; P00053; P00032; P00010; P00056; P06664; P00021; P04393; P00034; P00047; P05911; P00005; P00054; P00018; P00019"]
["MEKK3",null,"MAP3K3","71","rb",null,1,8,8.1,8.1,1,1.1000000000000001,"# 0255",".ANG., .BCR., .CANCER., .CCP., .CP., .CSP., .EGFR., .FGFR., .IMUF., .INT., .MAPK., .NFKB., .OP., .OPA., .P38., .RTK., .SREME., .ST.","B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Integrin signalling pathway; EGF receptor signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3","blood vessel development; intracellular signal transduction; MAPK cascade; negative regulation of cellular senescence; phosphorylation; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell proliferation in bone marrow; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of p38MAPK cascade; protein autophosphorylation; protein phosphorylation","ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol","MAPK signaling","mitogen-activated protein kinase kinase kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=4215","4215","26406",null,"480481","100513491","717866","Q99759","Q61084","A0A8I6A3I3","A0A8P0NN13","A0A287AGW3","A0A1D5QJ66","GO:0005737; GO:0005829","GO:0005524; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0001568; GO:0035556; GO:0000165; GO:2000773; GO:0016310; GO:0090050; GO:0071864; GO:0043123; GO:1900745; GO:0046777; GO:0006468","PTHR24361:SF656","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6855|UniProtKB=Q99759","P00010; P06664; P00021; P00034; P00018"]
["MEKK3",null,"MAP3K3","71","ms",null,1.1000000000000001,1,8,8,1.1000000000000001,8,"# 0502",".ANG., .BCR., .CANCER., .CCP., .CP., .CSP., .EGFR., .FGFR., .IMUF., .INT., .MAPK., .NFKB., .OP., .OPA., .P38., .RTK., .SREME., .ST.","B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Integrin signalling pathway; EGF receptor signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3","blood vessel development; intracellular signal transduction; MAPK cascade; negative regulation of cellular senescence; phosphorylation; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell proliferation in bone marrow; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of p38MAPK cascade; protein autophosphorylation; protein phosphorylation","ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol","MAPK signaling","mitogen-activated protein kinase kinase kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=4215","4215","26406",null,"480481","100513491","717866","Q99759","Q61084","A0A8I6A3I3","A0A8P0NN13","A0A287AGW3","A0A1D5QJ66","GO:0005737; GO:0005829","GO:0005524; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0001568; GO:0035556; GO:0000165; GO:2000773; GO:0016310; GO:0090050; GO:0071864; GO:0043123; GO:1900745; GO:0046777; GO:0006468","PTHR24361:SF656","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6855|UniProtKB=Q99759","P00010; P06664; P00021; P00034; P00018"]
["MEKK4",null,"MAP3K4","200","rb",null,7,7,"n/a","n/a","n/a","n/a","# 0440",".CSP., .EGFR., .FGFR., .IMUF., .INFM., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","p38 MAPK pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Oxidative stress response; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4","chorionic trophoblast cell differentiation; intracellular signal transduction; male germ-line sex determination; MAPK cascade; phosphorylation; placenta development; positive regulation of JUN kinase activity; positive regulation of p38MAPK cascade; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein phosphorylation; regulation of gene expression; response to UV-C","ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; perinuclear region of cytoplasm","MAPK signaling","mitogen-activated protein kinase kinase kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=4216","4216","26407","308106",null,null,null,"Q9Y6R4","O08648","A0A0G2K3R1","A0A8I3MP56","A0A5G2QLR1","A0A1D5Q359","GO:0005737; GO:0048471","GO:0005524; GO:0016301; GO:0004709; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0060718; GO:0035556; GO:0019100; GO:0000165; GO:0016310; GO:0001890; GO:0043507; GO:1900745; GO:0051973; GO:1904355; GO:0032212; GO:0006468; GO:0010468; GO:0010225","PTHR48016:SF32","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6856|UniProtKB=Q9Y6R4","P05918; P00036; P06664; P00021; P04393; P00034; P00047; P00046; P00018; P00031"]
["MERTK",null,"MERTK","110","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1384",".APO., .CD., .CSP., .MIG., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .ST., .TRASR.",null,"TYROSINE-PROTEIN KINASE MER","apoptotic cell clearance; cell migration; cell surface receptor signaling pathway; cell-cell signaling; establishment of localization in cell; lymphocyte activation; natural killer cell differentiation; negative regulation of cytokine production; negative regulation of leukocyte apoptotic process; negative regulation of lymphocyte activation; nervous system development; neutrophil clearance; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; platelet activation; positive regulation of kinase activity; positive regulation of phagocytosis; protein kinase B signaling; protein phosphorylation; retina development in camera-type eye; secretion by cell; spermatogenesis; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway; vagina development","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","cytoplasm; extracellular space; membrane; photoreceptor outer segment; plasma membrane; receptor complex","Tyrosine kinase / adaptor","MER proto-oncogene, tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=10461","10461","17289","65037",null,null,null,"Q12866","Q60805","P57097","A0A8I3NE12","A0A287A2E8","A0A1D5QYP2","GO:0005737; GO:0005615; GO:0016020; GO:0001750; GO:0005886; GO:0043235","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714","GO:0043277; GO:0016477; GO:0007166; GO:0007267; GO:0051649; GO:0046649; GO:0001779; GO:0001818; GO:2000107; GO:0051250; GO:0007399; GO:0097350; GO:0018108; GO:0006909; GO:0016310; GO:0030168; GO:0033674; GO:0050766; GO:0043491; GO:0006468; GO:0060041; GO:0032940; GO:0007283; GO:0034446; GO:0007169; GO:0060068","PTHR24416:SF257","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7027|UniProtKB=Q12866"]
["Metallothionein",null,"MT2A","42-15","rb",null,2,2,2,2,2,2,"# 0590",null,null,"METALLOTHIONEIN-2","cellular copper ion homeostasis; cellular response to cadmium ion; cellular response to copper ion; cellular response to erythropoietin; cellular response to interleukin-3; cellular response to metal ion; cellular response to zinc ion; cellular zinc ion homeostasis; detoxification of copper ion; negative regulation of growth","metal ion binding; protein binding; zinc ion binding","cytoplasm; cytosol; nucleus","Heavy metal binding","metallothionein 2A","http://www.ncbi.nlm.nih.gov/gene/?term=4502","4502",null,null,"100686073","396827",null,"P02795",null,null,"O19000","P79379",null,"GO:0005737; GO:0005829; GO:0005634","GO:0046872; GO:0005515; GO:0008270","GO:0006878; GO:0071276; GO:0071280; GO:0036018; GO:0036016; GO:0071248; GO:0071294; GO:0006882; GO:0010273; GO:0045926","PTHR23299:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7406|UniProtKB=P02795"]
["MICALL1",null,"MICALL1","93","rb",null,2,6,2,6,6,6,"# 0913",null,null,null,"endocytic recycling; endocytosis; neuron projection development; plasma membrane tubulation; protein localization to endosome; protein targeting to membrane; protein transport; receptor-mediated endocytosis; slow endocytic recycling","cadherin binding; identical protein binding; metal ion binding; phosphatidic acid binding; protein binding; small GTPase binding","early endosome; endosome; extrinsic component of membrane; late endosome; late endosome membrane; membrane; recycling endosome membrane; trans-Golgi network",null,"MICAL like 1","http://www.ncbi.nlm.nih.gov/gene/?term=85377","85377","27008","362958","474512",null,null,"Q8N3F8","Q8BGT6","D3ZQL6","A0A8I3MQQ2","A0A287A7W9",null,"GO:0005769; GO:0005768; GO:0019898; GO:0005770; GO:0031902; GO:0016020; GO:0055038; GO:0005802","GO:0045296; GO:0042802; GO:0046872; GO:0070300; GO:0005515; GO:0031267","GO:0032456; GO:0006897; GO:0031175; GO:0097320; GO:0036010; GO:0006612; GO:0015031; GO:0006898; GO:0032458"]
["Mili (PiwiL2)",null,"PIWIL2","110","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1704",".CCP., .CCY., .OP., .OT., .TRASR.",null,"PIWI-LIKE PROTEIN 2","cell differentiation; DNA methylation involved in gamete generation; germ-line stem cell population maintenance; meiotic cell cycle; negative regulation of circadian rhythm; negative regulation of transposition; nucleic acid phosphodiester bond hydrolysis; oogenesis; piRNA processing; positive regulation of histone H3-K14 acetylation; positive regulation of histone H3-K9 acetylation; positive regulation of meiosis I; positive regulation of translation; regulation of translation; rhythmic process; RNA 5'-end processing; RNA phosphodiester bond hydrolysis, endonucleolytic; RNA-mediated gene silencing; spermatogenesis","endonuclease activity; endoribonuclease activity; hydrolase activity; metal ion binding; mRNA binding; nuclease activity; nucleic acid binding; piRNA binding; polysome binding; protein binding; regulatory RNA binding; RNA binding","chromatoid body; cytoplasm; dense body; nucleus; P granule; perinucleolar chromocenter; PET complex; pi-body",null,"piwi like RNA-mediated gene silencing 2","http://www.ncbi.nlm.nih.gov/gene/?term=55124","55124","57746","306011",null,"100152834",null,"Q8TC59","Q8CDG1","D3ZRE1","A0A8I3PIN3","I3LE69","A0A5F7Z757","GO:0033391; GO:0005737; GO:0097433; GO:0005634; GO:0043186; GO:0010370; GO:1990923; GO:0071546","GO:0004519; GO:0004521; GO:0016787; GO:0046872; GO:0003729; GO:0004518; GO:0003676; GO:0034584; GO:1905538; GO:0005515; GO:0061980; GO:0003723","GO:0030154; GO:0043046; GO:0030718; GO:0051321; GO:0042754; GO:0010529; GO:0090305; GO:0048477; GO:0034587; GO:0071442; GO:2000617; GO:0060903; GO:0045727; GO:0006417; GO:0048511; GO:0000966; GO:0090502; GO:0031047; GO:0007283","PTHR22891:SF111","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17644|UniProtKB=Q8TC59"]
["MKK3/6 - phospho","Ser189/Ser207","MAP2K3, MAP2K6","40","rb",null,2.1,2.1,1.1000000000000001,4,4,6,"TK # 052",".APO., .CCKR., .CCP., .CCY., .CD., .CSP., .DDR., .DEV., .DI., .DRR., .EGFR., .FGFR., .HEPB., .HIPPO., .IMFR., .IMUF., .IMUR., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .P53S., .RAS., .RTK., .SREME., .ST., .TNF., .TOLL., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; Toll receptor signaling pathway; Oxidative stress response; EGF receptor signaling pathway; Apoptosis signaling pathway; CCKR signaling map","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3; DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","cardiac muscle contraction; cellular response to lipopolysaccharide; cellular response to sorbitol; cellular response to vascular endothelial growth factor stimulus; cellular senescence; heart development; inflammatory response; MAPK cascade; negative regulation of hippo signaling; p38MAPK cascade; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of DNA-templated transcription; positive regulation of MAPK cascade; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; protein phosphorylation; regulation of cytokine production; response to ischemia; signal transduction; apoptotic process; bone development; negative regulation of cold-induced thermogenesis; nucleotide-binding oligomerization domain containing signaling pathway; osteoblast differentiation; ovulation cycle process; positive regulation of apoptotic process; positive regulation of MAP kinase activity; positive regulation of prostaglandin secretion; regulation of cell cycle; regulation of gene expression; regulation of signal transduction by p53 class mediator; response to xenobiotic stimulus; signal transduction in response to DNA damage; stress-activated MAPK cascade","ATP binding; kinase activity; MAP kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity; phosphatase activator activity; protein serine/threonine kinase activator activity; transcription regulator activator activity","cytosol; membrane; nucleoplasm; cytoplasm; cytoskeleton; nucleus","MAPK signaling","mitogen-activated protein kinase kinase 3; mitogen-activated protein kinase kinase 6","http://www.ncbi.nlm.nih.gov/gene/?term=5606, http://www.ncbi.nlm.nih.gov/gene/?term=5608","5606, 5608","26397, 26399","114495","NA, 480454","100625946",null,"P46734, P52564","O09110, P70236","Q925D6","A0A8I3Q9A5, A0A8I3NBF5","A0A5K1UKA4","A0A5F8AE92, A0A1D5RHD1","GO:0005829; GO:0016020; GO:0005654; GO:0005737; GO:0005856; GO:0005634","GO:0005524; GO:0016301; GO:0004708; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0004713; GO:0016740; GO:0019211; GO:0043539; GO:0140537","GO:0060048; GO:0071222; GO:0072709; GO:0035924; GO:0090398; GO:0007507; GO:0006954; GO:0000165; GO:0035331; GO:0038066; GO:0018108; GO:0016310; GO:0043536; GO:0045893; GO:0043410; GO:0051770; GO:0045860; GO:0001934; GO:0006468; GO:0001817; GO:0002931; GO:0007165; GO:0006915; GO:0060348; GO:0120163; GO:0070423; GO:0001649; GO:0022602; GO:0043065; GO:0043406; GO:0032308; GO:0051726; GO:0010468; GO:1901796; GO:0009410; GO:0042770; GO:0051403","PTHR48013:SF21; PTHR48013:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6843|UniProtKB=P46734; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6846|UniProtKB=P52564","P00032; P05918; P06664; P00021; P04393; P00034; P00054; P00046; P00018; P00006; P06959"]
["MKK3/6 - phospho","Ser218/Thr222 (MMK3) / Ser207/Thr211 (MMK6)","MAP2K3, MAP2K6","40","rb",null,6,2,"n/a","n/a","n/a","n/a","# 1352",".APO., .CCKR., .CCP., .CCY., .CD., .CSP., .DDR., .DEV., .DI., .DRR., .EGFR., .FGFR., .HEPB., .HIPPO., .IMFR., .IMUF., .IMUR., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .P53S., .RAS., .RTK., .SREME., .ST., .TNF., .TOLL., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; Toll receptor signaling pathway; Oxidative stress response; EGF receptor signaling pathway; Apoptosis signaling pathway; CCKR signaling map","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3; DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","cardiac muscle contraction; cellular response to lipopolysaccharide; cellular response to sorbitol; cellular response to vascular endothelial growth factor stimulus; cellular senescence; heart development; inflammatory response; MAPK cascade; negative regulation of hippo signaling; p38MAPK cascade; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of DNA-templated transcription; positive regulation of MAPK cascade; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; protein phosphorylation; regulation of cytokine production; response to ischemia; signal transduction; apoptotic process; bone development; negative regulation of cold-induced thermogenesis; nucleotide-binding oligomerization domain containing signaling pathway; osteoblast differentiation; ovulation cycle process; positive regulation of apoptotic process; positive regulation of MAP kinase activity; positive regulation of prostaglandin secretion; regulation of cell cycle; regulation of gene expression; regulation of signal transduction by p53 class mediator; response to xenobiotic stimulus; signal transduction in response to DNA damage; stress-activated MAPK cascade","ATP binding; kinase activity; MAP kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity; phosphatase activator activity; protein serine/threonine kinase activator activity; transcription regulator activator activity","cytosol; membrane; nucleoplasm; cytoplasm; cytoskeleton; nucleus","MAPK signaling","mitogen-activated protein kinase kinase 3; mitogen-activated protein kinase kinase 6","http://www.ncbi.nlm.nih.gov/gene/?term=5606, http://www.ncbi.nlm.nih.gov/gene/?term=5608","5606, 5608","26397, 26399","114495","NA, 480454","100625946",null,"P46734, P52564","O09110, P70236","Q925D6","A0A8I3Q9A5, A0A8I3NBF5","A0A5K1UKA4","A0A5F8AE92, A0A1D5RHD1","GO:0005829; GO:0016020; GO:0005654; GO:0005737; GO:0005856; GO:0005634","GO:0005524; GO:0016301; GO:0004708; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0004713; GO:0016740; GO:0019211; GO:0043539; GO:0140537","GO:0060048; GO:0071222; GO:0072709; GO:0035924; GO:0090398; GO:0007507; GO:0006954; GO:0000165; GO:0035331; GO:0038066; GO:0018108; GO:0016310; GO:0043536; GO:0045893; GO:0043410; GO:0051770; GO:0045860; GO:0001934; GO:0006468; GO:0001817; GO:0002931; GO:0007165; GO:0006915; GO:0060348; GO:0120163; GO:0070423; GO:0001649; GO:0022602; GO:0043065; GO:0043406; GO:0032308; GO:0051726; GO:0010468; GO:1901796; GO:0009410; GO:0042770; GO:0051403","PTHR48013:SF21; PTHR48013:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6843|UniProtKB=P46734; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6846|UniProtKB=P52564","P00032; P05918; P06664; P00021; P04393; P00034; P00054; P00046; P00018; P00006; P06959"]
["MKK4 (SEK1)",null,"MAP2K4","44","rb",null,2,1,1,8,1.1000000000000001,8.1,"# 1966",".ANG., .APO., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DI., .EGFR., .FAS., .FGFR., .HEPB., .HUNT., .IMUF., .INT., .JNK., .MAPK., .OP., .OPA., .OXS., .P38., .RAS., .RTK., .SREME., .ST., .TNF., .TOLL.","CCKR signaling map; p38 MAPK pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Integrin signalling pathway; Angiogenesis; Oxidative stress response; EGF receptor signaling pathway; FAS signaling pathway; Apoptosis signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4","apoptotic process; cell growth involved in cardiac muscle cell development; cellular response to mechanical stimulus; cellular response to sorbitol; cellular senescence; Fc-epsilon receptor signaling pathway; JNK cascade; MAPK cascade; negative regulation of motor neuron apoptotic process; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of DNA replication; positive regulation of JNK cascade; positive regulation of neuron apoptotic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell apoptotic process; protein phosphorylation; response to wounding; signal transduction","ATP binding; JUN kinase kinase activity; kinase activity; MAP kinase kinase activity; molecular adaptor activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","axon; cytoplasm; cytosol; dendrite cytoplasm; nucleus; perikaryon","MAPK signaling","mitogen-activated protein kinase kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=6416","6416","26398",null,null,null,"718155","P45985","P47809","F1LP57","A0A8P0NZ84","A0A287B4Y9","A0A1D5QAU9","GO:0030424; GO:0005737; GO:0005829; GO:0032839; GO:0005634; GO:0043204","GO:0005524; GO:0008545; GO:0016301; GO:0004708; GO:0060090; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0006915; GO:0061049; GO:0071260; GO:0072709; GO:0090398; GO:0038095; GO:0007254; GO:0000165; GO:2000672; GO:0018108; GO:0016310; GO:0043065; GO:0045740; GO:0046330; GO:0043525; GO:0051770; GO:0001934; GO:0034393; GO:0006468; GO:0009611; GO:0007165","PTHR48013:SF29","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6844|UniProtKB=P45985","P06959; P05918; P00021; P04393; P00029; P00034; P00005; P00046; P00018; P00020; P00006"]
["MKK4 (SEK1) - phospho","Ser257/Thr261","MAP2K4","44","rb",null,2,2,2,8.1,1.1000000000000001,8,"# 1830",".ANG., .APO., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DI., .EGFR., .FAS., .FGFR., .HEPB., .HUNT., .IMUF., .INT., .JNK., .MAPK., .OP., .OPA., .OXS., .P38., .RAS., .RTK., .SREME., .ST., .TNF., .TOLL.","CCKR signaling map; p38 MAPK pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Integrin signalling pathway; Angiogenesis; Oxidative stress response; EGF receptor signaling pathway; FAS signaling pathway; Apoptosis signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4","apoptotic process; cell growth involved in cardiac muscle cell development; cellular response to mechanical stimulus; cellular response to sorbitol; cellular senescence; Fc-epsilon receptor signaling pathway; JNK cascade; MAPK cascade; negative regulation of motor neuron apoptotic process; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of DNA replication; positive regulation of JNK cascade; positive regulation of neuron apoptotic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell apoptotic process; protein phosphorylation; response to wounding; signal transduction","ATP binding; JUN kinase kinase activity; kinase activity; MAP kinase kinase activity; molecular adaptor activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","axon; cytoplasm; cytosol; dendrite cytoplasm; nucleus; perikaryon","MAPK signaling","mitogen-activated protein kinase kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=6416","6416","26398",null,null,null,"718155","P45985","P47809","F1LP57","A0A8P0NZ84","A0A287B4Y9","A0A1D5QAU9","GO:0030424; GO:0005737; GO:0005829; GO:0032839; GO:0005634; GO:0043204","GO:0005524; GO:0008545; GO:0016301; GO:0004708; GO:0060090; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0006915; GO:0061049; GO:0071260; GO:0072709; GO:0090398; GO:0038095; GO:0007254; GO:0000165; GO:2000672; GO:0018108; GO:0016310; GO:0043065; GO:0045740; GO:0046330; GO:0043525; GO:0051770; GO:0001934; GO:0034393; GO:0006468; GO:0009611; GO:0007165","PTHR48013:SF29","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6844|UniProtKB=P45985","P06959; P05918; P00021; P04393; P00029; P00034; P00005; P00046; P00018; P00020; P00006"]
["MKK6",null,"MAP2K6","36","rb",null,1,1.1000000000000001,1.1000000000000001,1.1000000000000001,1.1000000000000001,8.1,"# 0247",".APO., .CCKR., .CCP., .CCY., .CD., .CSP., .DDR., .DI., .DRR., .EGFR., .FGFR., .HEPB., .IMUF., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .P53S., .RAS., .RTK., .SREME., .ST., .TNF., .TOLL., .TRASR.","CCKR signaling map; p38 MAPK pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Oxidative stress response; EGF receptor signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6","apoptotic process; bone development; cardiac muscle contraction; cellular response to sorbitol; cellular senescence; MAPK cascade; negative regulation of cold-induced thermogenesis; nucleotide-binding oligomerization domain containing signaling pathway; osteoblast differentiation; ovulation cycle process; p38MAPK cascade; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of protein phosphorylation; protein phosphorylation; regulation of cell cycle; regulation of gene expression; regulation of signal transduction by p53 class mediator; response to ischemia; response to xenobiotic stimulus; signal transduction; signal transduction in response to DNA damage; stress-activated MAPK cascade","ATP binding; kinase activity; MAP kinase kinase activity; nucleotide binding; phosphatase activator activity; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transcription regulator activator activity; transferase activity","cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus","MAPK signaling","mitogen-activated protein kinase kinase 6","http://www.ncbi.nlm.nih.gov/gene/?term=5608","5608","26399","114495","480454","100625946",null,"P52564","P70236","Q925D6","A0A8I3NBF5","A0A5K1UKA4","A0A1D5RHD1","GO:0005737; GO:0005856; GO:0005829; GO:0005654; GO:0005634","GO:0005524; GO:0016301; GO:0004708; GO:0000166; GO:0019211; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0043539; GO:0004674; GO:0004713; GO:0140537; GO:0016740","GO:0006915; GO:0060348; GO:0060048; GO:0072709; GO:0090398; GO:0000165; GO:0120163; GO:0070423; GO:0001649; GO:0022602; GO:0038066; GO:0018108; GO:0016310; GO:0043065; GO:0043406; GO:0043410; GO:0051770; GO:0032308; GO:0001934; GO:0006468; GO:0051726; GO:0010468; GO:1901796; GO:0002931; GO:0009410; GO:0007165; GO:0042770; GO:0051403","PTHR48013:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6846|UniProtKB=P52564","P06959; P05918; P06664; P00021; P04393; P00046; P00018"]
["MKK7",null,"MAP2K7","48","rb",null,2,2,8,8,2,8,"# 1225",".ALZ., .APO., .CD., .CSP., .DI., .EGFR., .FGFR., .HEPB., .HUNT., .IMUF., .JNK., .MAPK., .OP., .OPA., .OT., .RAS., .RTK., .SREME., .ST., .TCR., .TNF., .TOLL., .TRASR.","Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; EGF receptor signaling pathway; Apoptosis signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7","apoptotic process; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to sorbitol; cellular senescence; Fc-epsilon receptor signaling pathway; JNK cascade; MAPK cascade; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron apoptotic process; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein phosphorylation; regulation of motor neuron apoptotic process; response to heat; response to osmotic stress; response to tumor necrosis factor; response to UV; response to wounding; signal transduction; stress-activated MAPK cascade","ATP binding; enzyme binding; JUN kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase activity; MAP kinase kinase activity; metal ion binding; mitogen-activated protein kinase kinase kinase binding; molecular function activator activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","cytoplasm; cytosol; nucleus","MAPK signaling","mitogen-activated protein kinase kinase 7","http://www.ncbi.nlm.nih.gov/gene/?term=5609","5609","26400","363855","485004","100520418",null,"O14733","Q8CE90","Q4KSH7","A0A8I3SBM5","A0A286ZVB5",null,"GO:0005737; GO:0005829; GO:0005634","GO:0005524; GO:0019899; GO:0008545; GO:0016301; GO:0000287; GO:0004707; GO:0004708; GO:0046872; GO:0031435; GO:0140677; GO:0000166; GO:0005515; GO:0008022; GO:0004672; GO:0019901; GO:0019903; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0006915; GO:0071347; GO:0071222; GO:0072709; GO:0090398; GO:0038095; GO:0007254; GO:0000165; GO:0018108; GO:0016310; GO:0045893; GO:0070374; GO:0046330; GO:0043507; GO:0043525; GO:0001934; GO:0051973; GO:1904355; GO:0032212; GO:0006468; GO:2000671; GO:0009408; GO:0006970; GO:0034612; GO:0009411; GO:0009611; GO:0007165; GO:0051403","PTHR48013:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6847|UniProtKB=O14733","P06664; P00021; P04393; P00029; P00018; P00006"]
["MKK7 - phospho","Ser271/Thr275","MAP2K7","48","rb",null,6.1,4,4,4,4,4,"TK # 059",".ALZ., .APO., .CD., .CSP., .DI., .EGFR., .FGFR., .HEPB., .HUNT., .IMUF., .JNK., .MAPK., .OP., .OPA., .OT., .RAS., .RTK., .SREME., .ST., .TCR., .TNF., .TOLL., .TRASR.","Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; EGF receptor signaling pathway; Apoptosis signaling pathway","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7","apoptotic process; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to sorbitol; cellular senescence; Fc-epsilon receptor signaling pathway; JNK cascade; MAPK cascade; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron apoptotic process; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein phosphorylation; regulation of motor neuron apoptotic process; response to heat; response to osmotic stress; response to tumor necrosis factor; response to UV; response to wounding; signal transduction; stress-activated MAPK cascade","ATP binding; enzyme binding; JUN kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase activity; MAP kinase kinase activity; metal ion binding; mitogen-activated protein kinase kinase kinase binding; molecular function activator activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","cytoplasm; cytosol; nucleus","MAPK signaling","mitogen-activated protein kinase kinase 7","http://www.ncbi.nlm.nih.gov/gene/?term=5609","5609","26400","363855","485004","100520418",null,"O14733","Q8CE90","Q4KSH7","A0A8I3SBM5","A0A286ZVB5",null,"GO:0005737; GO:0005829; GO:0005634","GO:0005524; GO:0019899; GO:0008545; GO:0016301; GO:0000287; GO:0004707; GO:0004708; GO:0046872; GO:0031435; GO:0140677; GO:0000166; GO:0005515; GO:0008022; GO:0004672; GO:0019901; GO:0019903; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0006915; GO:0071347; GO:0071222; GO:0072709; GO:0090398; GO:0038095; GO:0007254; GO:0000165; GO:0018108; GO:0016310; GO:0045893; GO:0070374; GO:0046330; GO:0043507; GO:0043525; GO:0001934; GO:0051973; GO:1904355; GO:0032212; GO:0006468; GO:2000671; GO:0009408; GO:0006970; GO:0034612; GO:0009411; GO:0009611; GO:0007165; GO:0051403","PTHR48013:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6847|UniProtKB=O14733","P06664; P00021; P04393; P00029; P00018; P00006"]
["MLK3",null,"MAP3K11","92","rb",null,2,4,4,4,4,4,"# 0399",".APO., .CCKR., .CD., .CSP., .JNK., .MAPK., .OPA., .RTK., .SREME., .ST.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11","cell cycle G1/S phase transition; cell death; JNK cascade; MAPK cascade; microtubule-based process; phosphorylation; positive regulation of apoptotic process; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron apoptotic process; protein autophosphorylation; protein phosphorylation","ATP binding; identical protein binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity","centrosome; cytoplasm; cytoskeleton; cytosol; membrane; microtubule; microtubule organizing center","MAPK signaling","mitogen-activated protein kinase kinase kinase 11","http://www.ncbi.nlm.nih.gov/gene/?term=4296","4296","26403","309168",null,null,null,"Q16584","Q80XI6","Q66HA1","A0A8I3PD03",null,null,"GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0016020; GO:0005874; GO:0005815","GO:0005524; GO:0042802; GO:0004706; GO:0016301; GO:0004709; GO:0031434; GO:0031435; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0106310; GO:0004674; GO:0031267; GO:0016740","GO:0044843; GO:0008219; GO:0007254; GO:0000165; GO:0007017; GO:0016310; GO:0043065; GO:0046330; GO:0043507; GO:0043525; GO:0046777; GO:0006468","PTHR44329:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6850|UniProtKB=Q16584","P06959; P06664"]
["MLK3 - phospho","Thr277/Ser281","MAP3K11","115, 92","rb",null,4,4,4,2.1,4,4,"# 0494",".APO., .CCKR., .CD., .CSP., .JNK., .MAPK., .OPA., .RTK., .SREME., .ST.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11","cell cycle G1/S phase transition; cell death; JNK cascade; MAPK cascade; microtubule-based process; phosphorylation; positive regulation of apoptotic process; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron apoptotic process; protein autophosphorylation; protein phosphorylation","ATP binding; identical protein binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity","centrosome; cytoplasm; cytoskeleton; cytosol; membrane; microtubule; microtubule organizing center","MAPK signaling","mitogen-activated protein kinase kinase kinase 11","http://www.ncbi.nlm.nih.gov/gene/?term=4296","4296","26403","309168",null,null,null,"Q16584","Q80XI6","Q66HA1","A0A8I3PD03",null,null,"GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0016020; GO:0005874; GO:0005815","GO:0005524; GO:0042802; GO:0004706; GO:0016301; GO:0004709; GO:0031434; GO:0031435; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0106310; GO:0004674; GO:0031267; GO:0016740","GO:0044843; GO:0008219; GO:0007254; GO:0000165; GO:0007017; GO:0016310; GO:0043065; GO:0046330; GO:0043507; GO:0043525; GO:0046777; GO:0006468","PTHR44329:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6850|UniProtKB=Q16584","P06959; P06664"]
["MLKL",null,"MLKL","54","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2217",".CD., .CSP., .IMUR., .OP., .OPA., .ST., .TNF., .VIR.",null,"MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN","cell surface receptor signaling pathway; defense response to virus; execution phase of necroptosis; necroptotic process; necroptotic signaling pathway; programmed cell death; protein homotrimerization; protein phosphorylation","ATP binding; JUN kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-containing complex binding","cell junction; cytoplasm; cytosol; membrane; nucleus; plasma membrane",null,"mixed lineage kinase domain like pseudokinase","http://www.ncbi.nlm.nih.gov/gene/?term=197259","197259","74568","690743",null,"100736836","710316","Q8NB16","Q9D2Y4","A0A8I5ZV82",null,"A0A287AG10","F7HMN7","GO:0030054; GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:0005886","GO:0005524; GO:0004706; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0004674; GO:0044877","GO:0007166; GO:0051607; GO:0097528; GO:0070266; GO:0097527; GO:0012501; GO:0070207; GO:0006468","PTHR44329:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=26617|UniProtKB=Q8NB16"]
["MLKL",null,"MLKL","54","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2448",".CD., .CSP., .IMUR., .OP., .OPA., .ST., .TNF., .VIR.",null,"MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN","cell surface receptor signaling pathway; defense response to virus; execution phase of necroptosis; necroptotic process; necroptotic signaling pathway; programmed cell death; protein homotrimerization; protein phosphorylation","ATP binding; JUN kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-containing complex binding","cell junction; cytoplasm; cytosol; membrane; nucleus; plasma membrane",null,"mixed lineage kinase domain like pseudokinase","http://www.ncbi.nlm.nih.gov/gene/?term=197259","197259","74568","690743",null,"100736836","710316","Q8NB16","Q9D2Y4","A0A8I5ZV82",null,"A0A287AG10","F7HMN7","GO:0030054; GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:0005886","GO:0005524; GO:0004706; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0004674; GO:0044877","GO:0007166; GO:0051607; GO:0097528; GO:0070266; GO:0097527; GO:0012501; GO:0070207; GO:0006468","PTHR44329:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=26617|UniProtKB=Q8NB16"]
["MLKL - phospho","Ser358","MLKL","54","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2421",".CD., .CSP., .IMUR., .OP., .OPA., .ST., .TNF., .VIR.",null,"MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN","cell surface receptor signaling pathway; defense response to virus; execution phase of necroptosis; necroptotic process; necroptotic signaling pathway; programmed cell death; protein homotrimerization; protein phosphorylation","ATP binding; JUN kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-containing complex binding","cell junction; cytoplasm; cytosol; membrane; nucleus; plasma membrane",null,"mixed lineage kinase domain like pseudokinase","http://www.ncbi.nlm.nih.gov/gene/?term=197259","197259","74568","690743",null,"100736836","710316","Q8NB16","Q9D2Y4","A0A8I5ZV82",null,"A0A287AG10","F7HMN7","GO:0030054; GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:0005886","GO:0005524; GO:0004706; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0004674; GO:0044877","GO:0007166; GO:0051607; GO:0097528; GO:0070266; GO:0097527; GO:0012501; GO:0070207; GO:0006468","PTHR44329:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=26617|UniProtKB=Q8NB16"]
["MLKL - phospho","Ser358/Thr357","MLKL","54","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2244",".CD., .CSP., .IMUR., .OP., .OPA., .ST., .TNF., .VIR.",null,"MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN","cell surface receptor signaling pathway; defense response to virus; execution phase of necroptosis; necroptotic process; necroptotic signaling pathway; programmed cell death; protein homotrimerization; protein phosphorylation","ATP binding; JUN kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-containing complex binding","cell junction; cytoplasm; cytosol; membrane; nucleus; plasma membrane",null,"mixed lineage kinase domain like pseudokinase","http://www.ncbi.nlm.nih.gov/gene/?term=197259","197259","74568","690743",null,"100736836","710316","Q8NB16","Q9D2Y4","A0A8I5ZV82",null,"A0A287AG10","F7HMN7","GO:0030054; GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:0005886","GO:0005524; GO:0004706; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0004674; GO:0044877","GO:0007166; GO:0051607; GO:0097528; GO:0070266; GO:0097527; GO:0012501; GO:0070207; GO:0006468","PTHR44329:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=26617|UniProtKB=Q8NB16"]
["MLKL -phospho","Ser345","MLKL","54","rb",null,2,1,"n/a","n/a","n/a","n/a","# 2449",".CD., .CSP., .IMUR., .OP., .OPA., .ST., .TNF., .VIR.",null,"MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN","cell surface receptor signaling pathway; defense response to virus; execution phase of necroptosis; necroptotic process; necroptotic signaling pathway; programmed cell death; protein homotrimerization; protein phosphorylation","ATP binding; JUN kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-containing complex binding","cell junction; cytoplasm; cytosol; membrane; nucleus; plasma membrane",null,"mixed lineage kinase domain like pseudokinase","http://www.ncbi.nlm.nih.gov/gene/?term=197259","197259","74568","690743",null,"100736836","710316","Q8NB16","Q9D2Y4","A0A8I5ZV82",null,"A0A287AG10","F7HMN7","GO:0030054; GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:0005886","GO:0005524; GO:0004706; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0004674; GO:0044877","GO:0007166; GO:0051607; GO:0097528; GO:0070266; GO:0097527; GO:0012501; GO:0070207; GO:0006468","PTHR44329:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=26617|UniProtKB=Q8NB16"]
["MMP13",null,"MMP13","54","ms",null,1,2,1,8,6,6,"# 0295",".ALZ., .DI., .OP.","Plasminogen activating cascade; Alzheimer disease-presenilin pathway","COLLAGENASE 3","bone mineralization; bone morphogenesis; collagen catabolic process; endochondral ossification; extracellular matrix disassembly; extracellular matrix organization; growth plate cartilage development; protein metabolic process; proteolysis; response to amyloid-beta","calcium ion binding; collagen binding; endopeptidase activity; hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; serine-type endopeptidase activity; zinc ion binding","extracellular matrix; extracellular region; extracellular space",null,"matrix metallopeptidase 13","http://www.ncbi.nlm.nih.gov/gene/?term=4322","4322","17386","171052","403763",null,"703980","P45452","P33435","G3V742","A0A8I3MWY2","A0A5G2QA64","F6YQ28","GO:0031012; GO:0005576; GO:0005615","GO:0005509; GO:0005518; GO:0004175; GO:0016787; GO:0046872; GO:0004222; GO:0008237; GO:0008233; GO:0004252; GO:0008270","GO:0030282; GO:0060349; GO:0030574; GO:0001958; GO:0022617; GO:0030198; GO:0003417; GO:0019538; GO:0006508; GO:1904645","PTHR10201:SF165","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7159|UniProtKB=P45452","P00050; P00004"]
["MMP7",null,"MMP7","30","ms",null,6,5,"n/a","n/a","n/a","n/a","# 0624",".ALZ., .CCKR., .CSP., .DEV., .DI., .MIG., .OP., .OPA., .OT., .WNT.","CCKR signaling map; Alzheimer disease-presenilin pathway; Wnt signaling pathway","MATRILYSIN","collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; positive regulation of cell migration; proteolysis","endopeptidase activity; hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; serine-type endopeptidase activity; zinc ion binding","extracellular exosome; extracellular matrix; extracellular region; extracellular space",null,"matrix metallopeptidase 7","http://www.ncbi.nlm.nih.gov/gene/?term=4316","4316","17393","25335","489432",null,"703072","P09237","Q3UN27","P50280","A0A8I3MCQ8","A0A5G2QX12","F7FE85","GO:0070062; GO:0031012; GO:0005576; GO:0005615","GO:0004175; GO:0016787; GO:0046872; GO:0004222; GO:0008237; GO:0008233; GO:0005515; GO:0004252; GO:0008270","GO:0030574; GO:0022617; GO:0030198; GO:0006509; GO:0031293; GO:0030335; GO:0006508","PTHR10201:SF143","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7174|UniProtKB=P09237","P06959; P00004; P00057"]
["MMP-9",null,"MMP9","92, 84","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2214",".ALZ., .APO., .BLC., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DI., .DRAS., .EGFR., .ErbB., .HEPB., .IMFR., .IMUR., .MIG., .OP., .OPA., .OT., .OXS., .PRC., .RTK., .SREME., .ST., .TNF.","CCKR signaling map; Plasminogen activating cascade; Alzheimer disease-presenilin pathway","MATRIX METALLOPROTEINASE-9","apoptotic process; cell migration; cellular response to cadmium ion; cellular response to reactive oxygen species; cellular response to UV-A; collagen catabolic process; embryo implantation; endodermal cell differentiation; ephrin receptor signaling pathway; extracellular matrix disassembly; extracellular matrix organization; macrophage differentiation; negative regulation of apoptotic process; negative regulation of cation channel activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of epithelial cell differentiation involved in kidney development; negative regulation of intrinsic apoptotic signaling pathway; positive regulation of apoptotic process; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; positive regulation of protein phosphorylation; positive regulation of receptor binding; positive regulation of release of cytochrome c from mitochondria; positive regulation of vascular associated smooth muscle cell proliferation; proteolysis; regulation of neuroinflammatory response; response to amyloid-beta; response to stimulus; skeletal system development","collagen binding; endopeptidase activity; hydrolase activity; identical protein binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; serine-type endopeptidase activity; zinc ion binding","collagen-containing extracellular matrix; extracellular exosome; extracellular matrix; extracellular region; extracellular space; ficolin-1-rich granule lumen; tertiary granule lumen",null,"matrix metallopeptidase 9","http://www.ncbi.nlm.nih.gov/gene/?term=4318","4318","17395",null,null,null,null,"P14780","P41245","A0A0G2JUD9","A0A8I3P478","A0A287AN90","F6W5A7","GO:0062023; GO:0070062; GO:0031012; GO:0005576; GO:0005615; GO:1904813; GO:1904724","GO:0005518; GO:0004175; GO:0016787; GO:0042802; GO:0046872; GO:0004222; GO:0008237; GO:0008233; GO:0005515; GO:0004252; GO:0008270","GO:0006915; GO:0016477; GO:0071276; GO:0034614; GO:0071492; GO:0030574; GO:0007566; GO:0035987; GO:0048013; GO:0022617; GO:0030198; GO:0030225; GO:0043066; GO:2001258; GO:2001268; GO:2000697; GO:2001243; GO:0043065; GO:0043388; GO:0045742; GO:0051549; GO:0001934; GO:1900122; GO:0090200; GO:1904707; GO:0006508; GO:0150077; GO:1904645; GO:0050896; GO:0001501","PTHR10201:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7176|UniProtKB=P14780","P06959; P00050; P00004"]
["Mnk1",null,"MKNK1","50","rb",null,2,2,8,8,8,1,"# 0422",".CSP., .CUR., .D100., .D200., .D300., .DRAS., .HIF., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .PDGF., .RTK., .SREME., .ST., .TRASR.","p38 MAPK pathway; Interleukin signaling pathway; PDGF signaling pathway; Oxidative stress response","MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1","intracellular signal transduction; peptidyl-serine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of translation","ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus","MAPK signaling","MAPK interacting serine/threonine kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=8569","8569","17346","500526",null,null,null,"Q9BUB5","A2A8W8","A0A0G2K3K7","A0A8I3P986","A0A287AEM0","A0A5F7ZPJ6","GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0035556; GO:0018105; GO:0016310; GO:0046777; GO:0006468; GO:0006417","PTHR24349:SF114","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7110|UniProtKB=Q9BUB5","P05918; P00036; P00047; P00046"]
["Mnk1 - phospho","Thr197/Thr202","MKNK1","50","rb",null,2,4,8,8,4,4,"# 0443",".CSP., .CUR., .D100., .D200., .D300., .DRAS., .HIF., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .PDGF., .RTK., .SREME., .ST., .TRASR.","p38 MAPK pathway; Interleukin signaling pathway; PDGF signaling pathway; Oxidative stress response","MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1","intracellular signal transduction; peptidyl-serine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of translation","ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus","MAPK signaling","MAPK interacting serine/threonine kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=8569","8569","17346","500526",null,null,null,"Q9BUB5","A2A8W8","A0A0G2K3K7","A0A8I3P986","A0A287AEM0","A0A5F7ZPJ6","GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0005524; GO:0009931; GO:0005516; GO:0004683; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0035556; GO:0018105; GO:0016310; GO:0046777; GO:0006468; GO:0006417","PTHR24349:SF114","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7110|UniProtKB=Q9BUB5","P05918; P00036; P00047; P00046"]
["MOB1",null,"MOB1A, MOB1B","25","rb",null,2,1.1000000000000001,8.1,8,6,6,"# 2096",".CCKR., .CSP., .DEV., .HIPPO., .OPA., .ST.","CCKR signaling map","MOB KINASE ACTIVATOR 1A; MOB KINASE ACTIVATOR 1B","hippo signaling; positive regulation of protein phosphorylation; signal transduction; regulation of protein autophosphorylation","metal ion binding; protein binding; protein kinase activator activity; kinase activator activity; kinase binding","cytoplasm; cytosol; extracellular exosome; nucleolus; nucleoplasm; nucleus","Hippo signaling","MOB kinase activator 1A; MOB kinase activator 1B","http://www.ncbi.nlm.nih.gov/gene/?term=55233, http://www.ncbi.nlm.nih.gov/gene/?term=92597","55233, 92597","232157, 68473",null,"612924","","","Q9H8S9, Q7L9L4","Q921Y0, Q8BPB0","A0A8I6A847, A0A8I5YCB8","A0A8I3P9B2",null,"F6SLK3","GO:0005737; GO:0005829; GO:0070062; GO:0005730; GO:0005654; GO:0005634","GO:0046872; GO:0005515; GO:0030295; GO:0019209; GO:0019900","GO:0035329; GO:0001934; GO:0007165; GO:0031952","PTHR22599:SF30; PTHR22599:SF63","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16015|UniProtKB=Q9H8S9; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=29801|UniProtKB=Q7L9L4","P06959"]
["MOB1 - phospho","Thr35","MOB1A","24","rb",null,1,1,1,8,8,8,"# 1928",".CCKR., .CSP., .DEV., .HIPPO., .OPA., .ST.","CCKR signaling map","MOB KINASE ACTIVATOR 1A","hippo signaling; positive regulation of protein phosphorylation; signal transduction","metal ion binding; protein binding; protein kinase activator activity","cytoplasm; cytosol; extracellular exosome; nucleolus; nucleoplasm; nucleus","Hippo signaling","MOB kinase activator 1A","http://www.ncbi.nlm.nih.gov/gene/?term=55233","55233","232157",null,"612924",null,null,"Q9H8S9","Q921Y0","A0A8I6A847","A0A8I3P9B2",null,"F6SLK3","GO:0005737; GO:0005829; GO:0070062; GO:0005730; GO:0005654; GO:0005634","GO:0046872; GO:0005515; GO:0030295","GO:0035329; GO:0001934; GO:0007165","PTHR22599:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16015|UniProtKB=Q9H8S9","P06959"]
["Mre11",null,"MRE11","81","rb",null,2,4,8,8,8,8,"# 1374",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .OP., .OPA., .ST.",null,"DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11","cell population proliferation; cellular response to DNA damage stimulus; chromosome organization; DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA strand resection involved in replication fork processing; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; homologous chromosome pairing at meiosis; homologous recombination; meiotic cell cycle; meiotic DNA double-strand break formation; mitochondrial double-strand break repair via homologous recombination; mitotic G2 DNA damage checkpoint signaling; mitotic G2/M transition checkpoint; mitotic intra-S DNA damage checkpoint signaling; negative regulation of apoptotic process; positive regulation of kinase activity; positive regulation of protein autophosphorylation; positive regulation of telomere maintenance; reciprocal meiotic recombination; regulation of mitotic recombination; sister chromatid cohesion; telomere maintenance; telomere maintenance via telomerase; telomeric 3' overhang formation","3'-5' exonuclease activity; 3'-5'-exodeoxyribonuclease activity; 5'-3' exonuclease activity; cadherin binding; DNA binding; DNA helicase activity; double-stranded DNA binding; endodeoxyribonuclease activity; endonuclease activity; exonuclease activity; hydrolase activity; identical protein binding; manganese ion binding; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA endodeoxyribonuclease activity","BRCA1-C complex; chromosomal region; chromosome; chromosome, telomeric region; cytoplasm; cytosol; Mre11 complex; nucleoplasm; nucleus; PML body; replication fork; site of double-strand break","DNA damage","MRE11 homolog, double strand break repair nuclease","http://www.ncbi.nlm.nih.gov/gene/?term=4361","4361","17535","64046",null,null,"697439","P49959","Q61216","A0A8I6A2X5","A0A8P0NXY2","A0A287BGY4","A0A1D5R7E2","GO:0070533; GO:0098687; GO:0005694; GO:0000781; GO:0005737; GO:0005829; GO:0030870; GO:0005654; GO:0005634; GO:0016605; GO:0005657; GO:0035861","GO:0008408; GO:0008296; GO:0008409; GO:0045296; GO:0003677; GO:0003678; GO:0003690; GO:0004520; GO:0004519; GO:0004527; GO:0016787; GO:0042802; GO:0030145; GO:0004518; GO:0005515; GO:0008022; GO:0000014","GO:0008283; GO:0006974; GO:0051276; GO:0000729; GO:0032508; GO:0006310; GO:0006281; GO:0110025; GO:0006302; GO:0000724; GO:0006303; GO:0007129; GO:0035825; GO:0051321; GO:0042138; GO:0097552; GO:0007095; GO:0044818; GO:0031573; GO:0043066; GO:0033674; GO:0031954; GO:0032206; GO:0007131; GO:0000019; GO:0007062; GO:0000723; GO:0007004; GO:0031860","PTHR10139:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7230|UniProtKB=P49959"]
["Mre11 - phospho","Ser676","MRE11","81","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1523",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .OP., .OPA., .ST.",null,"DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11","cell population proliferation; cellular response to DNA damage stimulus; chromosome organization; DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA strand resection involved in replication fork processing; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; homologous chromosome pairing at meiosis; homologous recombination; meiotic cell cycle; meiotic DNA double-strand break formation; mitochondrial double-strand break repair via homologous recombination; mitotic G2 DNA damage checkpoint signaling; mitotic G2/M transition checkpoint; mitotic intra-S DNA damage checkpoint signaling; negative regulation of apoptotic process; positive regulation of kinase activity; positive regulation of protein autophosphorylation; positive regulation of telomere maintenance; reciprocal meiotic recombination; regulation of mitotic recombination; sister chromatid cohesion; telomere maintenance; telomere maintenance via telomerase; telomeric 3' overhang formation","3'-5' exonuclease activity; 3'-5'-exodeoxyribonuclease activity; 5'-3' exonuclease activity; cadherin binding; DNA binding; DNA helicase activity; double-stranded DNA binding; endodeoxyribonuclease activity; endonuclease activity; exonuclease activity; hydrolase activity; identical protein binding; manganese ion binding; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA endodeoxyribonuclease activity","BRCA1-C complex; chromosomal region; chromosome; chromosome, telomeric region; cytoplasm; cytosol; Mre11 complex; nucleoplasm; nucleus; PML body; replication fork; site of double-strand break","DNA damage","MRE11 homolog, double strand break repair nuclease","http://www.ncbi.nlm.nih.gov/gene/?term=4361","4361","17535","64046",null,null,"697439","P49959","Q61216","A0A8I6A2X5","A0A8P0NXY2","A0A287BGY4","A0A1D5R7E2","GO:0070533; GO:0098687; GO:0005694; GO:0000781; GO:0005737; GO:0005829; GO:0030870; GO:0005654; GO:0005634; GO:0016605; GO:0005657; GO:0035861","GO:0008408; GO:0008296; GO:0008409; GO:0045296; GO:0003677; GO:0003678; GO:0003690; GO:0004520; GO:0004519; GO:0004527; GO:0016787; GO:0042802; GO:0030145; GO:0004518; GO:0005515; GO:0008022; GO:0000014","GO:0008283; GO:0006974; GO:0051276; GO:0000729; GO:0032508; GO:0006310; GO:0006281; GO:0110025; GO:0006302; GO:0000724; GO:0006303; GO:0007129; GO:0035825; GO:0051321; GO:0042138; GO:0097552; GO:0007095; GO:0044818; GO:0031573; GO:0043066; GO:0033674; GO:0031954; GO:0032206; GO:0007131; GO:0000019; GO:0007062; GO:0000723; GO:0007004; GO:0031860","PTHR10139:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7230|UniProtKB=P49959"]
["MRP1 (ABCC1)",null,"ABCC1","171","rb",null,7,7,"n/a","n/a","n/a","n/a","# 0733",".CSP., .DRR., .IMFR., .IMUR., .MIG., .OP., .OT., .OXS., .SREME.",null,"MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1","carboxylic acid transmembrane transport; cell chemotaxis; cellular response to amyloid-beta; cellular response to oxidative stress; cobalamin transport; export across plasma membrane; glutathione transmembrane transport; heme catabolic process; inorganic anion transport; leukotriene metabolic process; leukotriene transport; lipid transport; phospholipid translocation; positive regulation of inflammatory response; response to xenobiotic stimulus; sphingolipid translocation; transepithelial transport; transmembrane transport; transport across blood-brain barrier; xenobiotic metabolic process; xenobiotic transport; xenobiotic transport across blood-brain barrier","ABC-type glutathione S-conjugate transporter activity; ABC-type transporter activity; ABC-type vitamin B12 transporter activity; ABC-type xenobiotic transporter activity; ATP binding; ATP hydrolysis activity; ATPase-coupled inorganic anion transmembrane transporter activity; ATPase-coupled lipid transmembrane transporter activity; ATPase-coupled transmembrane transporter activity; carboxylic acid transmembrane transporter activity; efflux transmembrane transporter activity; glutathione transmembrane transporter activity; hydrolase activity; nucleotide binding; transmembrane transporter activity; xenobiotic transmembrane transporter activity","apical plasma membrane; basal plasma membrane; basolateral plasma membrane; extracellular exosome; lateral plasma membrane; membrane; plasma membrane",null,"ATP binding cassette subfamily C member 1","http://www.ncbi.nlm.nih.gov/gene/?term=4363","4363","17250","24565",null,null,null,"P33527","O35379","Q8CG09","A0A8P0NJI4","A0A286ZSQ7","F6WW02","GO:0016324; GO:0009925; GO:0016323; GO:0070062; GO:0016328; GO:0016020; GO:0005886","GO:0015431; GO:0140359; GO:0015420; GO:0008559; GO:0005524; GO:0016887; GO:0043225; GO:0034040; GO:0042626; GO:0046943; GO:0015562; GO:0034634; GO:0016787; GO:0000166; GO:0022857; GO:0042910","GO:1905039; GO:0060326; GO:1904646; GO:0034599; GO:0015889; GO:0140115; GO:0034775; GO:0042167; GO:0015698; GO:0006691; GO:0071716; GO:0006869; GO:0045332; GO:0050729; GO:0009410; GO:0099039; GO:0070633; GO:0055085; GO:0150104; GO:0006805; GO:0042908; GO:1990962","PTHR24223:SF241","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=51|UniProtKB=P33527"]
["MSK1",null,"RPS6KA5","90","rb",null,2,4,"n/a","n/a","n/a","n/a","# 0432",".BLC., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D100., .D200., .D300., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PDGF., .RTK., .SREME., .ST., .TNF., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p38 MAPK pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-5","axon guidance; histone modification; inflammatory response; interleukin-1-mediated signaling pathway; intracellular signal transduction; negative regulation of cytokine production; negative regulation of DNA-templated transcription; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; post-translational protein modification; protein phosphorylation; regulation of DNA-templated transcription; regulation of postsynapse organization","ATP binding; histone H2AS1 kinase activity; histone H3S10 kinase activity; histone H3S28 kinase activity; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","cytoplasm; nucleoplasm; nucleus","MAPK signaling","ribosomal protein S6 kinase A5","http://www.ncbi.nlm.nih.gov/gene/?term=9252","9252","73086","314384",null,null,null,"O75582","Q8C050","A0A0G2K366","A0A8I3NQ43",null,"F7G4I3","GO:0005737; GO:0005654; GO:0005634","GO:0005524; GO:0044024; GO:0035175; GO:0044022; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0007411; GO:0016570; GO:0006954; GO:0070498; GO:0035556; GO:0001818; GO:0045892; GO:0018105; GO:0018108; GO:0016310; GO:0032793; GO:0051092; GO:0045944; GO:0043687; GO:0006468; GO:0006355; GO:0099175","PTHR24351:SF115","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10434|UniProtKB=O75582","P00032; P05918; P00047"]
["MSK1 - phospho","Ser360","RPS6KA5","90","rb",null,2,2,1,6,4,6,"# 0216",".BLC., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D200., .D300., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PDGF., .RTK., .SREME., .ST., .TNF., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p38 MAPK pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-5","axon guidance; histone modification; inflammatory response; interleukin-1-mediated signaling pathway; intracellular signal transduction; negative regulation of cytokine production; negative regulation of DNA-templated transcription; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; post-translational protein modification; protein phosphorylation; regulation of DNA-templated transcription; regulation of postsynapse organization","ATP binding; histone H2AS1 kinase activity; histone H3S10 kinase activity; histone H3S28 kinase activity; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","cytoplasm; nucleoplasm; nucleus","MAPK signaling","ribosomal protein S6 kinase A5","http://www.ncbi.nlm.nih.gov/gene/?term=9252","9252","73086","314384",null,null,null,"O75582","Q8C050","A0A0G2K366","A0A8I3NQ43",null,"F7G4I3","GO:0005737; GO:0005654; GO:0005634","GO:0005524; GO:0044024; GO:0035175; GO:0044022; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0007411; GO:0016570; GO:0006954; GO:0070498; GO:0035556; GO:0001818; GO:0045892; GO:0018105; GO:0018108; GO:0016310; GO:0032793; GO:0051092; GO:0045944; GO:0043687; GO:0006468; GO:0006355; GO:0099175","PTHR24351:SF115","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10434|UniProtKB=O75582","P00032; P05918; P00047"]
["MSK1 - phospho","Ser360","RPS6KA5","90","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2373",".BLC., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D300., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PDGF., .RTK., .SREME., .ST., .TNF., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p38 MAPK pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-5","axon guidance; histone modification; inflammatory response; interleukin-1-mediated signaling pathway; intracellular signal transduction; negative regulation of cytokine production; negative regulation of DNA-templated transcription; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; post-translational protein modification; protein phosphorylation; regulation of DNA-templated transcription; regulation of postsynapse organization","ATP binding; histone H2AS1 kinase activity; histone H3S10 kinase activity; histone H3S28 kinase activity; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","cytoplasm; nucleoplasm; nucleus","MAPK signaling","ribosomal protein S6 kinase A5","http://www.ncbi.nlm.nih.gov/gene/?term=9252","9252","73086","314384",null,null,null,"O75582","Q8C050","A0A0G2K366","A0A8I3NQ43",null,"F7G4I3","GO:0005737; GO:0005654; GO:0005634","GO:0005524; GO:0044024; GO:0035175; GO:0044022; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0007411; GO:0016570; GO:0006954; GO:0070498; GO:0035556; GO:0001818; GO:0045892; GO:0018105; GO:0018108; GO:0016310; GO:0032793; GO:0051092; GO:0045944; GO:0043687; GO:0006468; GO:0006355; GO:0099175","PTHR24351:SF115","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10434|UniProtKB=O75582","P00032; P05918; P00047"]
["MSK1 - phospho","Ser376","RPS6KA5","90","rb",null,2,4,1.1000000000000001,8,8,8,"# 0431",".BLC., .CANCER., .CANPTHW., .CD., .CSP., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PDGF., .RTK., .SREME., .ST., .TNF., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p38 MAPK pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-5","axon guidance; histone modification; inflammatory response; interleukin-1-mediated signaling pathway; intracellular signal transduction; negative regulation of cytokine production; negative regulation of DNA-templated transcription; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; post-translational protein modification; protein phosphorylation; regulation of DNA-templated transcription; regulation of postsynapse organization","ATP binding; histone H2AS1 kinase activity; histone H3S10 kinase activity; histone H3S28 kinase activity; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","cytoplasm; nucleoplasm; nucleus","MAPK signaling","ribosomal protein S6 kinase A5","http://www.ncbi.nlm.nih.gov/gene/?term=9252","9252","73086","314384",null,null,null,"O75582","Q8C050","A0A0G2K366","A0A8I3NQ43",null,"F7G4I3","GO:0005737; GO:0005654; GO:0005634","GO:0005524; GO:0044024; GO:0035175; GO:0044022; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0007411; GO:0016570; GO:0006954; GO:0070498; GO:0035556; GO:0001818; GO:0045892; GO:0018105; GO:0018108; GO:0016310; GO:0032793; GO:0051092; GO:0045944; GO:0043687; GO:0006468; GO:0006355; GO:0099175","PTHR24351:SF115","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10434|UniProtKB=O75582","P00032; P05918; P00047"]
["MSK1 - phospho","Ser376","RPS6KA5","90","rb",null,2,1,1,6,1,1,"# 0740",".BLC., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D100., .D200., .D300., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PDGF., .RTK., .SREME., .ST., .TNF., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p38 MAPK pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-5","axon guidance; histone modification; inflammatory response; interleukin-1-mediated signaling pathway; intracellular signal transduction; negative regulation of cytokine production; negative regulation of DNA-templated transcription; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; post-translational protein modification; protein phosphorylation; regulation of DNA-templated transcription; regulation of postsynapse organization","ATP binding; histone H2AS1 kinase activity; histone H3S10 kinase activity; histone H3S28 kinase activity; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","cytoplasm; nucleoplasm; nucleus","MAPK signaling","ribosomal protein S6 kinase A5","http://www.ncbi.nlm.nih.gov/gene/?term=9252","9252","73086","314384",null,null,null,"O75582","Q8C050","A0A0G2K366","A0A8I3NQ43",null,"F7G4I3","GO:0005737; GO:0005654; GO:0005634","GO:0005524; GO:0044024; GO:0035175; GO:0044022; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0007411; GO:0016570; GO:0006954; GO:0070498; GO:0035556; GO:0001818; GO:0045892; GO:0018105; GO:0018108; GO:0016310; GO:0032793; GO:0051092; GO:0045944; GO:0043687; GO:0006468; GO:0006355; GO:0099175","PTHR24351:SF115","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10434|UniProtKB=O75582","P00032; P05918; P00047"]
["Mst1",null,"STK4","59","rb",null,1,2,8,8,8,1,"# 2126",".ANG., .APO., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .FOXO., .HIPPO., .MAPK., .MIG., .NSCLC., .OP., .OPA., .OT., .RAS., .RTK., .ST., .WNT.",null,"SERINE/THREONINE-PROTEIN KINASE 4","apoptotic process; branching involved in blood vessel morphogenesis; canonical Wnt signaling pathway; cell differentiation involved in embryonic placenta development; cell morphogenesis; cell population proliferation; central nervous system development; endocardium development; epithelial cell proliferation; extrinsic apoptotic signaling pathway via death domain receptors; hepatocyte apoptotic process; hippo signaling; intracellular signal transduction; keratinocyte differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; negative regulation of epithelial cell proliferation; negative regulation of organ growth; neural tube formation; organ growth; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of fat cell differentiation; positive regulation of hepatocyte apoptotic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein phosphorylation; positive regulation of substrate-dependent cell migration, cell attachment to substrate; primitive hemopoiesis; protein autophosphorylation; protein import into nucleus; protein phosphorylation; protein stabilization; protein tetramerization; regulation of cell differentiation involved in embryonic placenta development; regulation of MAPK cascade; signal transduction","ATP binding; identical protein binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; RNA polymerase II-specific DNA-binding transcription factor binding; transferase activity","cytoplasm; cytosol; nuclear body; nucleoplasm; nucleus; protein-containing complex","Hippo signaling","serine/threonine kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=6789","6789","58231",null,"477240",null,null,"Q13043","Q9JI11","A0A8I5Y708","A0A8I3NQ71",null,"A0A1D5Q8L4","GO:0005737; GO:0005829; GO:0016604; GO:0005654; GO:0005634; GO:0032991","GO:0005524; GO:0042802; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0106310; GO:0043539; GO:0004674; GO:0061629; GO:0016740","GO:0006915; GO:0001569; GO:0060070; GO:0060706; GO:0000902; GO:0008283; GO:0007417; GO:0003157; GO:0050673; GO:0008625; GO:0097284; GO:0035329; GO:0035556; GO:0030216; GO:0090090; GO:0008285; GO:0050680; GO:0046621; GO:0001841; GO:0035265; GO:0018105; GO:0016310; GO:0043065; GO:1902043; GO:0045600; GO:1903945; GO:0033138; GO:0032092; GO:0001934; GO:1904237; GO:0060215; GO:0046777; GO:0006606; GO:0006468; GO:0050821; GO:0051262; GO:0060800; GO:0043408; GO:0007165","PTHR48015:SF32","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11408|UniProtKB=Q13043"]
["Mst2",null,"STK3","60","rb",null,6,4,8,8,2,8,"# 2061",".APH., .APO., .CCP., .CD., .CP., .CSP., .DEV., .HIPPO., .JNK., .MAPK., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TRASR., .WNT.",null,"SERINE/THREONINE-PROTEIN KINASE 3","apoptotic process; canonical Wnt signaling pathway; cell differentiation involved in embryonic placenta development; cell population proliferation; central nervous system development; endocardium development; epithelial cell proliferation; extrinsic apoptotic signaling pathway via death domain receptors; hepatocyte apoptotic process; hippo signaling; intracellular signal transduction; JNK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; negative regulation of epithelial cell proliferation; negative regulation of organ growth; neural tube formation; organ growth; phosphorylation; positive regulation of apoptotic process; positive regulation of DNA-binding transcription factor activity; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of fat cell differentiation; positive regulation of JNK cascade; positive regulation of protein binding; positive regulation of protein kinase B signaling; primitive hemopoiesis; protein import into nucleus; protein kinase B signaling; protein phosphorylation; protein stabilization; protein tetramerization; regulation of cell differentiation involved in embryonic placenta development; regulation of MAPK cascade; selective autophagy; signal transduction","ATP binding; identical protein binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; nucleus; protein-containing complex","Hippo signaling","serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=6788","6788","56274",null,null,null,null,"Q13188","Q9JI10","A0A8I6G6P5","A0A8I3PKJ8","A0A286ZIU4","A0A1D5QD89","GO:0005737; GO:0005829; GO:0005634; GO:0032991","GO:0005524; GO:0042802; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0043539; GO:0004674; GO:0016740","GO:0006915; GO:0060070; GO:0060706; GO:0008283; GO:0007417; GO:0003157; GO:0050673; GO:0008625; GO:0097284; GO:0035329; GO:0035556; GO:0007254; GO:0090090; GO:0008285; GO:0050680; GO:0046621; GO:0001841; GO:0035265; GO:0016310; GO:0043065; GO:0051091; GO:1902043; GO:0045600; GO:0046330; GO:0032092; GO:0051897; GO:0060215; GO:0006606; GO:0043491; GO:0006468; GO:0050821; GO:0051262; GO:0060800; GO:0043408; GO:0061912; GO:0007165","PTHR48015:SF23","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11406|UniProtKB=Q13188"]
["MTA1",null,"MTA1","82-78","rb",null,6,2,6.1,2.1,6,6,"# 1633",".CD., .CSP., .DREP., .OP., .OPA., .OT., .ST., .TRASR., .UBI.",null,"METASTASIS-ASSOCIATED PROTEIN MTA1","chromatin remodeling; circadian regulation of gene expression; double-strand break repair; entrainment of circadian clock by photoperiod; epigenetic regulation of gene expression; histone deacetylation; locomotor rhythm; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of protein autoubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of cell fate specification; regulation of DNA-templated transcription; regulation of stem cell differentiation; response to ionizing radiation; rhythmic process; signal transduction","chromatin binding; DNA binding; histone deacetylase binding; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity","cytoplasm; cytoskeleton; cytosol; intracellular membrane-bounded organelle; microtubule; nuclear envelope; nucleoplasm; nucleus; NuRD complex","Nucleosome remodeling / deacetylation NuRD complex","metastasis associated 1","http://www.ncbi.nlm.nih.gov/gene/?term=9112","9112",null,"64520",null,null,null,"Q13330","Q8K4B0","A0A140TA98","A0A8I3PRE7",null,"A0A1D5Q4K1","GO:0005737; GO:0005856; GO:0005829; GO:0043231; GO:0005874; GO:0005635; GO:0005654; GO:0005634; GO:0016581","GO:0003682; GO:0003677; GO:0042826; GO:0046872; GO:0005515; GO:0000978; GO:0061629; GO:0043565; GO:0003713; GO:0003714","GO:0006338; GO:0032922; GO:0006302; GO:0043153; GO:0040029; GO:0016575; GO:0045475; GO:0045892; GO:0000122; GO:0045893; GO:1902499; GO:0043161; GO:0042659; GO:0006355; GO:2000736; GO:0010212; GO:0048511; GO:0007165","PTHR10865:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7410|UniProtKB=Q13330"]
["MTA2",null,"MTA2","75","rb",null,2,2,1,6,1.1000000000000001,8,"# 1631",".CD., .CSP., .MIG., .OP., .OT., .P53S., .TRASR.","p53 pathway","METASTASIS-ASSOCIATED PROTEIN MTA2","chromatin organization; chromatin remodeling; DNA methylation; DNA-templated transcription; histone deacetylation; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of cell fate specification; regulation of DNA-templated transcription; regulation of fibroblast migration; regulation of stem cell differentiation","chromatin binding; DNA binding; DNA-binding transcription factor binding; histone deacetylase activity; histone deacetylase binding; metal ion binding; nucleosomal DNA binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription coregulator activity; transcription corepressor activity","chromatin; chromosome, telomeric region; histone deacetylase complex; membrane; nucleoplasm; nucleus; NuRD complex; protein-containing complex; transcription regulator complex","Nucleosome-remodeling / component of histone-deacetylase multiprotein complex (NuRD)","metastasis associated 1 family member 2","http://www.ncbi.nlm.nih.gov/gene/?term=9219","9219","23942",null,"476057",null,null,"O94776","Q9R190","F7F888","A0A8I3N2N1","A0A287AYU1","F7EC89","GO:0000785; GO:0000781; GO:0000118; GO:0016020; GO:0005654; GO:0005634; GO:0016581; GO:0032991; GO:0005667","GO:0003682; GO:0003677; GO:0140297; GO:0004407; GO:0042826; GO:0046872; GO:0031492; GO:0005515; GO:0061629; GO:0043565; GO:0003713; GO:0003712; GO:0003714","GO:0006325; GO:0006338; GO:0006306; GO:0006351; GO:0016575; GO:0045892; GO:0000122; GO:0045893; GO:0045944; GO:0042659; GO:0006355; GO:0010762; GO:2000736","PTHR10865:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7411|UniProtKB=O94776","P00059"]
["mTOR",null,"MTOR","289","rb",null,2,1,1,6,2,2,"# 2721",".ALZ., .AML., .AMPK., .APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .DMTOR., .EGFR., .GLI., .HIF., .HUNT., .IMFR., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PRC., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TRASR.","p53 pathway by glucose deprivation; Interleukin signaling pathway; PDGF signaling pathway; Hypoxia response via HIF activation","SERINE/THREONINE-PROTEIN KINASE MTOR","activation of protein kinase B activity; anoikis; behavioral response to pain; calcineurin-NFAT signaling cascade; cardiac cell development; cardiac muscle cell development; cardiac muscle contraction; cardiac muscle tissue development; cell projection organization; cellular response to amino acid starvation; cellular response to amino acid stimulus; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to leucine; cellular response to leucine starvation; cellular response to nutrient levels; cellular response to osmotic stress; cellular response to starvation; cytoskeleton organization; 'de novo' pyrimidine nucleobase biosynthetic process; energy reserve metabolic process; germ cell development; heart morphogenesis; heart valve morphogenesis; inflammatory response; lysosome organization; macroautophagy; multicellular organism growth; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of cell size; negative regulation of macroautophagy; neuronal action potential; nucleus localization; oligodendrocyte differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell growth; positive regulation of cytoplasmic translational initiation; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of glycolytic process; positive regulation of keratinocyte migration; positive regulation of lamellipodium assembly; positive regulation of lipid biosynthetic process; positive regulation of myotube differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of pentose-phosphate shunt; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of response to stimulus; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase III; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; positive regulation of translation; positive regulation of wound healing, spreading of epidermal cells; post-embryonic development; protein autophosphorylation; protein catabolic process; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of autophagy; regulation of cell growth; regulation of cell size; regulation of cellular component organization; regulation of cellular response to heat; regulation of cellular response to stress; regulation of circadian rhythm; regulation of GTPase activity; regulation of locomotor rhythm; regulation of macroautophagy; regulation of membrane permeability; regulation of myelination; regulation of nucleobase-containing compound metabolic process; regulation of osteoclast differentiation; regulation of protein kinase activity; regulation of protein kinase B signaling; regulation of protein phosphorylation; regulation of signal transduction by p53 class mediator; response to amino acid; response to chemical; response to heat; response to insulin; response to nutrient; response to nutrient levels; response to stress; rhythmic process; ruffle organization; T-helper 1 cell lineage commitment; TOR signaling; TORC1 signaling; voluntary musculoskeletal movement","ATP binding; identical protein binding; kinase activity; nucleotide binding; phosphoprotein binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; ribosome binding; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding; RNA polymerase III type 3 promoter sequence-specific DNA binding; TFIIIC-class transcription factor complex binding; transferase activity","cytoplasm; cytoplasmic vesicle; cytosol; dendrite; endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; lysosomal membrane; lysosome; membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus; phagocytic vesicle; PML body; TORC1 complex; TORC2 complex","mTOR signaling","mechanistic target of rapamycin kinase","http://www.ncbi.nlm.nih.gov/gene/?term=2475","2475","56717",null,"478232",null,null,"P42345","Q9JLN9","A0A0G2JX74","A0A8P0NI49","A0A287BKJ8","A0A1D5QLE3","GO:0005737; GO:0031410; GO:0005829; GO:0030425; GO:0012505; GO:0005783; GO:0005789; GO:0005794; GO:0000139; GO:0043231; GO:0005765; GO:0005764; GO:0016020; GO:0005741; GO:0005739; GO:0005635; GO:0005654; GO:0005634; GO:0045335; GO:0016605; GO:0031931; GO:0031932","GO:0005524; GO:0042802; GO:0016301; GO:0000166; GO:0051219; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0043022; GO:0001002; GO:0001003; GO:0001006; GO:0001156; GO:0016740","GO:0032148; GO:0043276; GO:0048266; GO:0033173; GO:0055006; GO:0055013; GO:0060048; GO:0048738; GO:0030030; GO:0034198; GO:0071230; GO:0006974; GO:0071456; GO:0071233; GO:1990253; GO:0031669; GO:0071470; GO:0009267; GO:0007010; GO:0006207; GO:0006112; GO:0007281; GO:0003007; GO:0003179; GO:0006954; GO:0007040; GO:0016236; GO:0035264; GO:0043066; GO:0010507; GO:0070885; GO:0045792; GO:0016242; GO:0019228; GO:0051647; GO:0048709; GO:0018105; GO:0018107; GO:0016310; GO:0030838; GO:0030307; GO:1904690; GO:0010718; GO:0010628; GO:0045821; GO:0051549; GO:0010592; GO:0046889; GO:0010831; GO:0048714; GO:1905857; GO:0050731; GO:0032516; GO:0051247; GO:0001934; GO:0048584; GO:0051496; GO:0045945; GO:1901838; GO:0045727; GO:1903691; GO:0009791; GO:0046777; GO:0030163; GO:0006468; GO:0032956; GO:0010506; GO:0001558; GO:0008361; GO:0051128; GO:1900034; GO:0080135; GO:0042752; GO:0043087; GO:1904059; GO:0016241; GO:0090559; GO:0031641; GO:0019219; GO:0045670; GO:0045859; GO:0051896; GO:0001932; GO:1901796; GO:0043200; GO:0042221; GO:0009408; GO:0032868; GO:0007584; GO:0031667; GO:0006950; GO:0048511; GO:0031529; GO:0002296; GO:0031929; GO:0038202; GO:0050882","PTHR11139:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3942|UniProtKB=P42345","P04397; P00036; P00047; P00030"]
["mTOR - phospho","Ser2448","MTOR","289","rb",null,1.1000000000000001,2,6,7,6,6,"# 2326",".ALZ., .AML., .AMPK., .APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .DDR., .DI., .EGFR., .GLI., .HIF., .HUNT., .IMFR., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PRC., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TRASR.","p53 pathway by glucose deprivation; Interleukin signaling pathway; PDGF signaling pathway; Hypoxia response via HIF activation","SERINE/THREONINE-PROTEIN KINASE MTOR","activation of protein kinase B activity; anoikis; behavioral response to pain; calcineurin-NFAT signaling cascade; cardiac cell development; cardiac muscle cell development; cardiac muscle contraction; cardiac muscle tissue development; cell projection organization; cellular response to amino acid starvation; cellular response to amino acid stimulus; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to leucine; cellular response to leucine starvation; cellular response to nutrient levels; cellular response to osmotic stress; cellular response to starvation; cytoskeleton organization; 'de novo' pyrimidine nucleobase biosynthetic process; energy reserve metabolic process; germ cell development; heart morphogenesis; heart valve morphogenesis; inflammatory response; lysosome organization; macroautophagy; multicellular organism growth; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of cell size; negative regulation of macroautophagy; neuronal action potential; nucleus localization; oligodendrocyte differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell growth; positive regulation of cytoplasmic translational initiation; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of glycolytic process; positive regulation of keratinocyte migration; positive regulation of lamellipodium assembly; positive regulation of lipid biosynthetic process; positive regulation of myotube differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of pentose-phosphate shunt; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of response to stimulus; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase III; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; positive regulation of translation; positive regulation of wound healing, spreading of epidermal cells; post-embryonic development; protein autophosphorylation; protein catabolic process; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of autophagy; regulation of cell growth; regulation of cell size; regulation of cellular component organization; regulation of cellular response to heat; regulation of cellular response to stress; regulation of circadian rhythm; regulation of GTPase activity; regulation of locomotor rhythm; regulation of macroautophagy; regulation of membrane permeability; regulation of myelination; regulation of nucleobase-containing compound metabolic process; regulation of osteoclast differentiation; regulation of protein kinase activity; regulation of protein kinase B signaling; regulation of protein phosphorylation; regulation of signal transduction by p53 class mediator; response to amino acid; response to chemical; response to heat; response to insulin; response to nutrient; response to nutrient levels; response to stress; rhythmic process; ruffle organization; T-helper 1 cell lineage commitment; TOR signaling; TORC1 signaling; voluntary musculoskeletal movement","ATP binding; identical protein binding; kinase activity; nucleotide binding; phosphoprotein binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; ribosome binding; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding; RNA polymerase III type 3 promoter sequence-specific DNA binding; TFIIIC-class transcription factor complex binding; transferase activity","cytoplasm; cytoplasmic vesicle; cytosol; dendrite; endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; lysosomal membrane; lysosome; membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus; phagocytic vesicle; PML body; TORC1 complex; TORC2 complex","mTOR signaling","mechanistic target of rapamycin kinase","http://www.ncbi.nlm.nih.gov/gene/?term=2475","2475","56717",null,"478232",null,null,"P42345","Q9JLN9","A0A0G2JX74","A0A8P0NI49","A0A287BKJ8","A0A1D5QLE3","GO:0005737; GO:0031410; GO:0005829; GO:0030425; GO:0012505; GO:0005783; GO:0005789; GO:0005794; GO:0000139; GO:0043231; GO:0005765; GO:0005764; GO:0016020; GO:0005741; GO:0005739; GO:0005635; GO:0005654; GO:0005634; GO:0045335; GO:0016605; GO:0031931; GO:0031932","GO:0005524; GO:0042802; GO:0016301; GO:0000166; GO:0051219; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0043022; GO:0001002; GO:0001003; GO:0001006; GO:0001156; GO:0016740","GO:0032148; GO:0043276; GO:0048266; GO:0033173; GO:0055006; GO:0055013; GO:0060048; GO:0048738; GO:0030030; GO:0034198; GO:0071230; GO:0006974; GO:0071456; GO:0071233; GO:1990253; GO:0031669; GO:0071470; GO:0009267; GO:0007010; GO:0006207; GO:0006112; GO:0007281; GO:0003007; GO:0003179; GO:0006954; GO:0007040; GO:0016236; GO:0035264; GO:0043066; GO:0010507; GO:0070885; GO:0045792; GO:0016242; GO:0019228; GO:0051647; GO:0048709; GO:0018105; GO:0018107; GO:0016310; GO:0030838; GO:0030307; GO:1904690; GO:0010718; GO:0010628; GO:0045821; GO:0051549; GO:0010592; GO:0046889; GO:0010831; GO:0048714; GO:1905857; GO:0050731; GO:0032516; GO:0051247; GO:0001934; GO:0048584; GO:0051496; GO:0045945; GO:1901838; GO:0045727; GO:1903691; GO:0009791; GO:0046777; GO:0030163; GO:0006468; GO:0032956; GO:0010506; GO:0001558; GO:0008361; GO:0051128; GO:1900034; GO:0080135; GO:0042752; GO:0043087; GO:1904059; GO:0016241; GO:0090559; GO:0031641; GO:0019219; GO:0045670; GO:0045859; GO:0051896; GO:0001932; GO:1901796; GO:0043200; GO:0042221; GO:0009408; GO:0032868; GO:0007584; GO:0031667; GO:0006950; GO:0048511; GO:0031529; GO:0002296; GO:0031929; GO:0038202; GO:0050882","PTHR11139:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3942|UniProtKB=P42345","P04397; P00036; P00047; P00030"]
["mTOR - phospho","Ser2448","MTOR","289","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2648",".ALZ., .AML., .AMPK., .APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .DMTOR., .EGFR., .GLI., .HIF., .HUNT., .IMFR., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PRC., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TRASR.","p53 pathway by glucose deprivation; Interleukin signaling pathway; PDGF signaling pathway; Hypoxia response via HIF activation","SERINE/THREONINE-PROTEIN KINASE MTOR","activation of protein kinase B activity; anoikis; behavioral response to pain; calcineurin-NFAT signaling cascade; cardiac cell development; cardiac muscle cell development; cardiac muscle contraction; cardiac muscle tissue development; cell projection organization; cellular response to amino acid starvation; cellular response to amino acid stimulus; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to leucine; cellular response to leucine starvation; cellular response to nutrient levels; cellular response to osmotic stress; cellular response to starvation; cytoskeleton organization; 'de novo' pyrimidine nucleobase biosynthetic process; energy reserve metabolic process; germ cell development; heart morphogenesis; heart valve morphogenesis; inflammatory response; lysosome organization; macroautophagy; multicellular organism growth; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of cell size; negative regulation of macroautophagy; neuronal action potential; nucleus localization; oligodendrocyte differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell growth; positive regulation of cytoplasmic translational initiation; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of glycolytic process; positive regulation of keratinocyte migration; positive regulation of lamellipodium assembly; positive regulation of lipid biosynthetic process; positive regulation of myotube differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of pentose-phosphate shunt; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of response to stimulus; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase III; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; positive regulation of translation; positive regulation of wound healing, spreading of epidermal cells; post-embryonic development; protein autophosphorylation; protein catabolic process; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of autophagy; regulation of cell growth; regulation of cell size; regulation of cellular component organization; regulation of cellular response to heat; regulation of cellular response to stress; regulation of circadian rhythm; regulation of GTPase activity; regulation of locomotor rhythm; regulation of macroautophagy; regulation of membrane permeability; regulation of myelination; regulation of nucleobase-containing compound metabolic process; regulation of osteoclast differentiation; regulation of protein kinase activity; regulation of protein kinase B signaling; regulation of protein phosphorylation; regulation of signal transduction by p53 class mediator; response to amino acid; response to chemical; response to heat; response to insulin; response to nutrient; response to nutrient levels; response to stress; rhythmic process; ruffle organization; T-helper 1 cell lineage commitment; TOR signaling; TORC1 signaling; voluntary musculoskeletal movement","ATP binding; identical protein binding; kinase activity; nucleotide binding; phosphoprotein binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; ribosome binding; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding; RNA polymerase III type 3 promoter sequence-specific DNA binding; TFIIIC-class transcription factor complex binding; transferase activity","cytoplasm; cytoplasmic vesicle; cytosol; dendrite; endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; lysosomal membrane; lysosome; membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus; phagocytic vesicle; PML body; TORC1 complex; TORC2 complex","mTOR signaling","mechanistic target of rapamycin kinase","http://www.ncbi.nlm.nih.gov/gene/?term=2475","2475","56717",null,"478232",null,null,"P42345","Q9JLN9","A0A0G2JX74","A0A8P0NI49","A0A287BKJ8","A0A1D5QLE3","GO:0005737; GO:0031410; GO:0005829; GO:0030425; GO:0012505; GO:0005783; GO:0005789; GO:0005794; GO:0000139; GO:0043231; GO:0005765; GO:0005764; GO:0016020; GO:0005741; GO:0005739; GO:0005635; GO:0005654; GO:0005634; GO:0045335; GO:0016605; GO:0031931; GO:0031932","GO:0005524; GO:0042802; GO:0016301; GO:0000166; GO:0051219; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0043022; GO:0001002; GO:0001003; GO:0001006; GO:0001156; GO:0016740","GO:0032148; GO:0043276; GO:0048266; GO:0033173; GO:0055006; GO:0055013; GO:0060048; GO:0048738; GO:0030030; GO:0034198; GO:0071230; GO:0006974; GO:0071456; GO:0071233; GO:1990253; GO:0031669; GO:0071470; GO:0009267; GO:0007010; GO:0006207; GO:0006112; GO:0007281; GO:0003007; GO:0003179; GO:0006954; GO:0007040; GO:0016236; GO:0035264; GO:0043066; GO:0010507; GO:0070885; GO:0045792; GO:0016242; GO:0019228; GO:0051647; GO:0048709; GO:0018105; GO:0018107; GO:0016310; GO:0030838; GO:0030307; GO:1904690; GO:0010718; GO:0010628; GO:0045821; GO:0051549; GO:0010592; GO:0046889; GO:0010831; GO:0048714; GO:1905857; GO:0050731; GO:0032516; GO:0051247; GO:0001934; GO:0048584; GO:0051496; GO:0045945; GO:1901838; GO:0045727; GO:1903691; GO:0009791; GO:0046777; GO:0030163; GO:0006468; GO:0032956; GO:0010506; GO:0001558; GO:0008361; GO:0051128; GO:1900034; GO:0080135; GO:0042752; GO:0043087; GO:1904059; GO:0016241; GO:0090559; GO:0031641; GO:0019219; GO:0045670; GO:0045859; GO:0051896; GO:0001932; GO:1901796; GO:0043200; GO:0042221; GO:0009408; GO:0032868; GO:0007584; GO:0031667; GO:0006950; GO:0048511; GO:0031529; GO:0002296; GO:0031929; GO:0038202; GO:0050882","PTHR11139:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3942|UniProtKB=P42345","P04397; P00036; P00047; P00030"]
["mTOR - phospho","Ser2481","MTOR","289","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2481",".ALZ., .AML., .AMPK., .APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DMTOR., .EGFR., .GLI., .HIF., .HUNT., .IMFR., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PRC., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TRASR.","p53 pathway by glucose deprivation; Interleukin signaling pathway; PDGF signaling pathway; Hypoxia response via HIF activation","SERINE/THREONINE-PROTEIN KINASE MTOR","activation of protein kinase B activity; anoikis; behavioral response to pain; calcineurin-NFAT signaling cascade; cardiac cell development; cardiac muscle cell development; cardiac muscle contraction; cardiac muscle tissue development; cell projection organization; cellular response to amino acid starvation; cellular response to amino acid stimulus; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to leucine; cellular response to leucine starvation; cellular response to nutrient levels; cellular response to osmotic stress; cellular response to starvation; cytoskeleton organization; 'de novo' pyrimidine nucleobase biosynthetic process; energy reserve metabolic process; germ cell development; heart morphogenesis; heart valve morphogenesis; inflammatory response; lysosome organization; macroautophagy; multicellular organism growth; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of cell size; negative regulation of macroautophagy; neuronal action potential; nucleus localization; oligodendrocyte differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell growth; positive regulation of cytoplasmic translational initiation; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of glycolytic process; positive regulation of keratinocyte migration; positive regulation of lamellipodium assembly; positive regulation of lipid biosynthetic process; positive regulation of myotube differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of pentose-phosphate shunt; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of response to stimulus; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase III; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; positive regulation of translation; positive regulation of wound healing, spreading of epidermal cells; post-embryonic development; protein autophosphorylation; protein catabolic process; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of autophagy; regulation of cell growth; regulation of cell size; regulation of cellular component organization; regulation of cellular response to heat; regulation of cellular response to stress; regulation of circadian rhythm; regulation of GTPase activity; regulation of locomotor rhythm; regulation of macroautophagy; regulation of membrane permeability; regulation of myelination; regulation of nucleobase-containing compound metabolic process; regulation of osteoclast differentiation; regulation of protein kinase activity; regulation of protein kinase B signaling; regulation of protein phosphorylation; regulation of signal transduction by p53 class mediator; response to amino acid; response to chemical; response to heat; response to insulin; response to nutrient; response to nutrient levels; response to stress; rhythmic process; ruffle organization; T-helper 1 cell lineage commitment; TOR signaling; TORC1 signaling; voluntary musculoskeletal movement","ATP binding; identical protein binding; kinase activity; nucleotide binding; phosphoprotein binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; ribosome binding; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding; RNA polymerase III type 3 promoter sequence-specific DNA binding; TFIIIC-class transcription factor complex binding; transferase activity","cytoplasm; cytoplasmic vesicle; cytosol; dendrite; endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; lysosomal membrane; lysosome; membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus; phagocytic vesicle; PML body; TORC1 complex; TORC2 complex","mTOR signaling","mechanistic target of rapamycin kinase","http://www.ncbi.nlm.nih.gov/gene/?term=2475","2475","56717",null,"478232",null,null,"P42345","Q9JLN9","A0A0G2JX74","A0A8P0NI49","A0A287BKJ8","A0A1D5QLE3","GO:0005737; GO:0031410; GO:0005829; GO:0030425; GO:0012505; GO:0005783; GO:0005789; GO:0005794; GO:0000139; GO:0043231; GO:0005765; GO:0005764; GO:0016020; GO:0005741; GO:0005739; GO:0005635; GO:0005654; GO:0005634; GO:0045335; GO:0016605; GO:0031931; GO:0031932","GO:0005524; GO:0042802; GO:0016301; GO:0000166; GO:0051219; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0043022; GO:0001002; GO:0001003; GO:0001006; GO:0001156; GO:0016740","GO:0032148; GO:0043276; GO:0048266; GO:0033173; GO:0055006; GO:0055013; GO:0060048; GO:0048738; GO:0030030; GO:0034198; GO:0071230; GO:0006974; GO:0071456; GO:0071233; GO:1990253; GO:0031669; GO:0071470; GO:0009267; GO:0007010; GO:0006207; GO:0006112; GO:0007281; GO:0003007; GO:0003179; GO:0006954; GO:0007040; GO:0016236; GO:0035264; GO:0043066; GO:0010507; GO:0070885; GO:0045792; GO:0016242; GO:0019228; GO:0051647; GO:0048709; GO:0018105; GO:0018107; GO:0016310; GO:0030838; GO:0030307; GO:1904690; GO:0010718; GO:0010628; GO:0045821; GO:0051549; GO:0010592; GO:0046889; GO:0010831; GO:0048714; GO:1905857; GO:0050731; GO:0032516; GO:0051247; GO:0001934; GO:0048584; GO:0051496; GO:0045945; GO:1901838; GO:0045727; GO:1903691; GO:0009791; GO:0046777; GO:0030163; GO:0006468; GO:0032956; GO:0010506; GO:0001558; GO:0008361; GO:0051128; GO:1900034; GO:0080135; GO:0042752; GO:0043087; GO:1904059; GO:0016241; GO:0090559; GO:0031641; GO:0019219; GO:0045670; GO:0045859; GO:0051896; GO:0001932; GO:1901796; GO:0043200; GO:0042221; GO:0009408; GO:0032868; GO:0007584; GO:0031667; GO:0006950; GO:0048511; GO:0031529; GO:0002296; GO:0031929; GO:0038202; GO:0050882","PTHR11139:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3942|UniProtKB=P42345","P04397; P00036; P00047; P00030"]
["MUC1 (CD227)",null,"MUC1","400, 230","ms",null,1,4,8,8,8,8,"# 0324",".APO., .CD., .CSP., .OP., .OT., .P53S., .TRASR.",null,"MUCIN-1","DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA-templated transcription; localization; negative regulation of cell adhesion mediated by integrin; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of transcription by competitive promoter binding; positive regulation of histone H4 acetylation; positive regulation of transcription from RNA polymerase II promoter in response to stress; regulation of transcription from RNA polymerase II promoter in response to stress","p53 binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription coregulator activity","apical plasma membrane; chromatin; cytoplasm; extracellular exosome; extracellular region; extracellular space; Golgi lumen; membrane; nucleus; plasma membrane; vesicle","MAPK signaling","mucin 1, cell surface associated","http://www.ncbi.nlm.nih.gov/gene/?term=4582","4582","17829",null,null,null,null,"P15941","A0A0R4J0H1","A0A8I6GM17","A0A8P0NIM1","A0A5G2QGF8","A0A1D5Q923","GO:0016324; GO:0000785; GO:0005737; GO:0070062; GO:0005576; GO:0005615; GO:0005796; GO:0016020; GO:0005634; GO:0005886; GO:0031982","GO:0002039; GO:0005515; GO:0000978; GO:0003712","GO:0006977; GO:0006978; GO:0006351; GO:0051179; GO:0033629; GO:1902166; GO:0010944; GO:0090240; GO:0036003; GO:0043618","PTHR10006:SF19","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7508|UniProtKB=P15941"]
["MVP (LRP)",null,"MVP","110","ms",null,1,1,2,1,1,1,"# 0519",".CSP., .EGFR., .ErbB., .OPA., .RTK., .ST.",null,"MAJOR VAULT PROTEIN","ERBB signaling pathway; mRNA transport; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein autophosphorylation; negative regulation of protein tyrosine kinase activity; protein transport","identical protein binding; protein binding; protein kinase binding; protein phosphatase binding","cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; membrane; nuclear pore; nucleus; perinuclear region of cytoplasm; ribonucleoprotein complex; secretory granule lumen","Drug resistance","major vault protein","http://www.ncbi.nlm.nih.gov/gene/?term=9961","9961",null,"64681","479783",null,"706736","Q14764","D3Z2N7","A0A140TAE0","A0A8I3MGN1","I3LQ79","G7NQI2","GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005576; GO:1904813; GO:0016020; GO:0005643; GO:0005634; GO:0048471; GO:1990904; GO:0034774","GO:0042802; GO:0005515; GO:0019901; GO:0019903","GO:0038127; GO:0051028; GO:0042059; GO:0031953; GO:0061099; GO:0015031","PTHR14165:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7531|UniProtKB=Q14764"]
["MYBBP1A (Myb-binding protein 1A)",null,"MYBBP1A","160","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1109",".APO., .CD., .CSP., .OP., .OT., .P53S., .TRASR.",null,"MYB-BINDING PROTEIN 1A","cellular response to glucose starvation; chromatin remodeling; circadian regulation of gene expression; intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of DNA-templated transcription; osteoblast differentiation; positive regulation of anoikis; positive regulation of histone acetylation; positive regulation of transcription by RNA polymerase I; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase III; regulation of DNA-templated transcription; regulation of G1 to G0 transition; respiratory electron transport chain; rhythmic process; ribosome biogenesis","DNA binding; E-box binding; RNA binding; sequence-specific DNA binding; transcription corepressor activity","B-WICH complex; cytoplasm; intracellular membrane-bounded organelle; membrane; NLS-dependent protein nuclear import complex; nucleolus; nucleoplasm; nucleus","Transcription regulation","MYB binding protein 1a","http://www.ncbi.nlm.nih.gov/gene/?term=10514","10514","18432",null,null,null,null,"Q9BQG0","Q7TPV4","A0A8I6AF11","A0A8P0SJL7","A0A286ZYY8","A0A1D5RBD3","GO:0110016; GO:0005737; GO:0043231; GO:0016020; GO:0042564; GO:0005730; GO:0005654; GO:0005634","GO:0003677; GO:0070888; GO:0003723; GO:0043565; GO:0003714","GO:0042149; GO:0006338; GO:0032922; GO:0072332; GO:0045892; GO:0001649; GO:2000210; GO:0035066; GO:0045943; GO:0045944; GO:0045945; GO:0006355; GO:1903450; GO:0022904; GO:0048511; GO:0042254","PTHR13213:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7546|UniProtKB=Q9BQG0"]
["MYBL1",null,"MYBL1","85","rb",null,2,2,2,2,2,2,"# 1149",".CCP., .CCY., .OP., .OT., .TRASR.",null,"MYB-RELATED PROTEIN A","cell differentiation; male meiosis I; mitotic cell cycle; negative regulation of transposition; positive regulation of DNA-templated transcription; positive regulation of piRNA transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; spermatogenesis","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding","nucleoplasm; nucleus","Transcription factor","MYB proto-oncogene like 1","http://www.ncbi.nlm.nih.gov/gene/?term=4603","4603",null,null,null,null,null,"P10243","A0A087WPK9","A0A8I6AI21","A0A8I3P586","A0A286ZU12","F6S017","GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0000981; GO:0000978","GO:0030154; GO:0007141; GO:0000278; GO:0010529; GO:0045893; GO:0140543; GO:0045944; GO:0006355; GO:0007283","PTHR45614:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7547|UniProtKB=P10243"]
["Myd88",null,"MYD88","33","rb",null,1,4,"n/a","n/a","n/a","n/a","# 1651",".APO., .CCP., .CD., .CP., .CSP., .DI., .DRR., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TOLL., .TRASR., .VIR.","Toll receptor signaling pathway","MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88","3'-UTR-mediated mRNA stabilization; apoptotic process; cell surface receptor signaling pathway; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to organic substance; cellular response to oxidised low-density lipoprotein particle stimulus; chromatin remodeling; cytokine-mediated signaling pathway; defense response to bacterium; defense response to Gram-positive bacterium; defense response to protozoan; defense response to virus; establishment of endothelial intestinal barrier; gene expression; histone methylation; I-kappaB kinase/NF-kappaB signaling; immune system process; immunoglobulin mediated immune response; induced systemic resistance; inflammatory response; innate immune response; interleukin-1-mediated signaling pathway; JNK cascade; leukocyte activation involved in inflammatory response; lipopolysaccharide-mediated signaling pathway; MyD88-dependent toll-like receptor signaling pathway; neutrophil activation involved in immune response; neutrophil-mediated killing of bacterium; phagocytosis; positive regulation of chemokine production; positive regulation of cytokine production involved in inflammatory response; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; positive regulation of interleukin-17 production; positive regulation of interleukin-23 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of lymphocyte proliferation; positive regulation of macrophage cytokine production; positive regulation of NF-kappaB transcription factor activity; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of type I interferon production; regulation of cell population proliferation; regulation of chemokine (C-X-C motif) ligand 1 production; regulation of chemokine (C-X-C motif) ligand 2 production; regulation of gene expression; regulation of inflammatory response; regulation of interleukin-6 production; regulation of neutrophil migration; regulation of tumor necrosis factor production; response to amine; response to amino acid; response to ethanol; response to interleukin-1; response to lipopolysaccharide; response to molecule of fungal origin; response to organic cyclic compound; response to organonitrogen compound; response to peptidoglycan; response to virus; signal transduction; skin development; Toll signaling pathway; toll-like receptor 8 signaling pathway; type I interferon-mediated signaling pathway","ATP-dependent histone chaperone activity; death receptor binding; identical protein binding; interleukin-1 receptor binding; protein binding; protein self-association; signaling receptor binding; TIR domain binding; Toll binding; Toll-like receptor binding","cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane; postsynaptic density; protein-containing complex",null,"MYD88 innate immune signal transduction adaptor","http://www.ncbi.nlm.nih.gov/gene/?term=4615","4615","17874","301059",null,null,null,"Q99836","P22366","Q6Y1S1","A0A8P0NVB2","A0A140TAK4","A0A1D5QD46","GO:0005737; GO:0005829; GO:0010008; GO:0005634; GO:0005886; GO:0014069; GO:0032991","GO:0140674; GO:0005123; GO:0042802; GO:0005149; GO:0005515; GO:0043621; GO:0005102; GO:0070976; GO:0005121; GO:0035325","GO:0070935; GO:0006915; GO:0007166; GO:0071222; GO:0071260; GO:0071310; GO:0140052; GO:0006338; GO:0019221; GO:0042742; GO:0050830; GO:0042832; GO:0051607; GO:0090557; GO:0010467; GO:0016571; GO:0007249; GO:0002376; GO:0016064; GO:0009682; GO:0006954; GO:0045087; GO:0070498; GO:0007254; GO:0002269; GO:0031663; GO:0002755; GO:0002283; GO:0070944; GO:0006909; GO:0032722; GO:1900017; GO:0010628; GO:0043123; GO:0032731; GO:0032740; GO:0032747; GO:0032755; GO:0032757; GO:0046330; GO:0050671; GO:0060907; GO:0051092; GO:1900227; GO:0048661; GO:0045944; GO:0032760; GO:0032481; GO:0042127; GO:2000338; GO:2000341; GO:0010468; GO:0050727; GO:0032675; GO:1902622; GO:0032680; GO:0014075; GO:0043200; GO:0045471; GO:0070555; GO:0032496; GO:0002238; GO:0014070; GO:0010243; GO:0032494; GO:0009615; GO:0007165; GO:0043588; GO:0008063; GO:0034158; GO:0060337","PTHR15079:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7562|UniProtKB=Q99836","P00054"]
["MYPT1",null,"PPP1R12A","140","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2178",".cAMP., .CCP., .CCY., .CSP., .DRR., .GPCR., .OP., .OPA., .OT., .PLAT., .ST., .TRASR.",null,"PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12A","cellular response to xenobiotic stimulus; centrosome cycle; mitotic cell cycle; negative regulation of catalytic activity; positive regulation of myosin-light-chain-phosphatase activity; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; regulation of cell adhesion; regulation of establishment of endothelial barrier; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport; signal transduction","14-3-3 protein binding; enzyme inhibitor activity; phosphatase regulator activity; protein binding; protein kinase binding","A band; actin cytoskeleton; centrosome; contractile fiber; cytoplasm; cytoskeleton; cytosol; focal adhesion; kinetochore; nucleolus; nucleoplasm; plasma membrane; PTW/PP1 phosphatase complex; Z disc",null,"protein phosphatase 1 regulatory subunit 12A","http://www.ncbi.nlm.nih.gov/gene/?term=4659","4659","17931","116670",null,null,null,"O14974","Q9DBR7","Q10728","A0A8P0P174",null,"A0A1D5QP53","GO:0031672; GO:0015629; GO:0005813; GO:0043292; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0000776; GO:0005730; GO:0005654; GO:0005886; GO:0072357; GO:0030018","GO:0071889; GO:0004857; GO:0019208; GO:0005515; GO:0019901","GO:0071466; GO:0007098; GO:0000278; GO:0043086; GO:0035508; GO:0045944; GO:0006470; GO:0030155; GO:1903140; GO:0035507; GO:0046822; GO:0007165","PTHR24179:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7618|UniProtKB=O14974"]
["MYPT1 - phospho","Thr696","PPP1R12A","140","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2110",".cAMP., .CCP., .CCY., .CSP., .DRR., .GPCR., .OP., .OPA., .OT., .PLAT., .ST., .TRASR.",null,"PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12A","cellular response to xenobiotic stimulus; centrosome cycle; mitotic cell cycle; negative regulation of catalytic activity; positive regulation of myosin-light-chain-phosphatase activity; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; regulation of cell adhesion; regulation of establishment of endothelial barrier; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport; signal transduction","14-3-3 protein binding; enzyme inhibitor activity; phosphatase regulator activity; protein binding; protein kinase binding","A band; actin cytoskeleton; centrosome; contractile fiber; cytoplasm; cytoskeleton; cytosol; focal adhesion; kinetochore; nucleolus; nucleoplasm; plasma membrane; PTW/PP1 phosphatase complex; Z disc",null,"protein phosphatase 1 regulatory subunit 12A","http://www.ncbi.nlm.nih.gov/gene/?term=4659","4659","17931","116670",null,null,null,"O14974","Q9DBR7","Q10728","A0A8P0P174",null,"A0A1D5QP53","GO:0031672; GO:0015629; GO:0005813; GO:0043292; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0000776; GO:0005730; GO:0005654; GO:0005886; GO:0072357; GO:0030018","GO:0071889; GO:0004857; GO:0019208; GO:0005515; GO:0019901","GO:0071466; GO:0007098; GO:0000278; GO:0043086; GO:0035508; GO:0045944; GO:0006470; GO:0030155; GO:1903140; GO:0035507; GO:0046822; GO:0007165","PTHR24179:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7618|UniProtKB=O14974"]
["Na+/K+-ATPase beta2",null,"ATP1B2","45","ms",null,1,4,8,8,5,8,"# 0522",".cAMP., .CSP., .GPCR., .MIG., .OP., .OT.",null,"SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2","cell adhesion; cell communication by electrical coupling involved in cardiac conduction; cell-substrate adhesion; cellular potassium ion homeostasis; cellular sodium ion homeostasis; ion transport; lateral ventricle development; membrane repolarization; motor behavior; negative regulation of glial cell migration; neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration; photoreceptor cell maintenance; plasma membrane bounded cell projection organization; positive regulation of ATP-dependent activity; positive regulation of neuron projection development; positive regulation of potassium ion import across plasma membrane; positive regulation of potassium ion transmembrane transporter activity; positive regulation of sodium ion export across plasma membrane; potassium ion import across plasma membrane; potassium ion transport; protein stabilization; retina homeostasis; sodium ion export across plasma membrane; sodium ion transport; third ventricle development; transport across blood-brain barrier","ATPase activator activity; ATPase binding; protein binding; protein heterodimerization activity; protein-macromolecule adaptor activity","apical plasma membrane; astrocyte end-foot; astrocyte projection; cell body membrane; cell periphery; cell projection membrane; cytoplasm; external side of plasma membrane; lateral plasma membrane; membrane; neuron to neuron synapse; photoreceptor inner segment; plasma membrane; sodium:potassium-exchanging ATPase complex","Cytoskeletal regulation / Adhesion","ATPase Na+/K+ transporting subunit beta 2","http://www.ncbi.nlm.nih.gov/gene/?term=482","482","11932","24214",null,null,null,"P14415","P14231","Q5M9H4","A0A8I3PQA5","F1ST41","A0A1D5R2R3","GO:0016324; GO:0097450; GO:0097449; GO:0044298; GO:0071944; GO:0031253; GO:0005737; GO:0009897; GO:0016328; GO:0016020; GO:0098984; GO:0001917; GO:0005886; GO:0005890","GO:0001671; GO:0051117; GO:0005515; GO:0046982; GO:0030674","GO:0007155; GO:0086064; GO:0031589; GO:0030007; GO:0006883; GO:0006811; GO:0021670; GO:0086009; GO:0061744; GO:1903976; GO:0021944; GO:0045494; GO:0120036; GO:0032781; GO:0010976; GO:1903288; GO:1901018; GO:1903278; GO:1990573; GO:0006813; GO:0050821; GO:0001895; GO:0036376; GO:0006814; GO:0021678; GO:0150104","PTHR11523:SF26","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=805|UniProtKB=P14415"]
["Naked1",null,"NKD1","61, 59","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0676",".CSP., .DEV., .HIPPO., .MIG., .OP., .OT., .WNT.","Wnt signaling pathway","PROTEIN NAKED CUTICLE HOMOLOG 1","eye photoreceptor cell differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of convergent extension involved in axis elongation; negative regulation of Wnt signaling pathway; positive regulation of non-canonical Wnt signaling pathway via JNK cascade; positive regulation of protein catabolic process; positive regulation of Wnt signaling pathway, planar cell polarity pathway; regulation of cell migration involved in somitogenic axis elongation; somatic muscle development; Wnt signaling pathway","calcium ion binding; metal ion binding; PDZ domain binding; protein binding","cytoplasm; membrane; plasma membrane; protein phosphatase type 2A complex","Development","NKD inhibitor of WNT signaling pathway 1","http://www.ncbi.nlm.nih.gov/gene/?term=85407","85407","93960","364952",null,null,null,"Q969G9","Q99MH6","D4AAV5","A0A8I3MWF8",null,"A0A5F7ZEB9","GO:0005737; GO:0016020; GO:0005886; GO:0000159","GO:0005509; GO:0046872; GO:0030165; GO:0005515","GO:0001754; GO:0090090; GO:1901233; GO:0030178; GO:1901231; GO:0045732; GO:2000096; GO:0090249; GO:0007525; GO:0016055","PTHR22611:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17045|UniProtKB=Q969G9","P00057"]
["Nanog",null,"NANOG","42","ms",null,1,4,8,8,1,8,"# 0957",".CCP., .CP., .OP., .OT., .TRASR.",null,"HOMEOBOX PROTEIN NANOG-RELATED","cell differentiation; endodermal cell fate specification; negative regulation of transcription by RNA polymerase II; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of cell differentiation; regulation of DNA-templated transcription; regulation of gene expression; regulation of transcription by RNA polymerase II; somatic stem cell population maintenance; stem cell population maintenance","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus",null,"Nanog homeobox","http://www.ncbi.nlm.nih.gov/gene/?term=79923","79923","71950","414065",null,null,"715746","Q9H9S0","Q80Z64","D3ZS29","A0A8I3Q4J3",null,"F7GQZ2","GO:0000785; GO:0043231; GO:0005730; GO:0005654; GO:0005634","GO:0003677; GO:0003700; GO:0000981; GO:0001227; GO:0005515; GO:0000978; GO:0000977; GO:1990837; GO:0000976","GO:0030154; GO:0001714; GO:0000122; GO:2000648; GO:0045944; GO:0045595; GO:0006355; GO:0010468; GO:0006357; GO:0035019; GO:0019827","PTHR24327:SF79","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20857|UniProtKB=Q9H9S0"]
["Napsin A",null,"NAPSA","38","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0760",null,null,"NAPSIN-A","membrane protein proteolysis; proteolysis; surfactant homeostasis","aspartic-type endopeptidase activity; endopeptidase activity; hydrolase activity; peptidase activity; protein binding","alveolar lamellar body; extracellular exosome; extracellular region; extracellular space; lysosome; multivesicular body lumen","Tumor marker","napsin A aspartic peptidase","http://www.ncbi.nlm.nih.gov/gene/?term=9476","9476","16541",null,null,"100525581",null,"O96009","O09043","F7FL28","A0A8P0N696","A0A287AH87","A0A5F8A9X8","GO:0097208; GO:0070062; GO:0005576; GO:0005615; GO:0005764; GO:0097486","GO:0004190; GO:0004175; GO:0016787; GO:0008233; GO:0005515","GO:0033619; GO:0006508; GO:0043129","PTHR47966:SF56","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13395|UniProtKB=O96009"]
["N-Cadherin",null,"CDH2","130","ms",null,2,1,1,8,1,2.1,"# 0762",".CADH., .CSP., .DEV., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .WNT.","Cadherin signaling pathway; Wnt signaling pathway","CADHERIN-2","blood vessel morphogenesis; brain development; brain morphogenesis; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell migration; cell-cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell adhesion via plasma-membrane adhesion molecules; cell-cell junction assembly; cerebral cortex development; detection of muscle stretch; glial cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homeostasis of number of cells; homophilic cell adhesion via plasma membrane adhesion molecules; mesenchymal cell migration; negative regulation of canonical Wnt signaling pathway; neural crest cell development; neuroepithelial cell differentiation; neuroligin clustering involved in postsynaptic membrane assembly; neuronal stem cell population maintenance; positive regulation of MAPK cascade; positive regulation of synaptic vesicle clustering; protein localization to plasma membrane; radial glial cell differentiation; regulation of axonogenesis; regulation of oligodendrocyte progenitor proliferation; regulation of postsynaptic density protein 95 clustering; regulation of synaptic transmission, glutamatergic; striated muscle cell differentiation; synapse assembly; synaptic vesicle clustering; telencephalon development; type B pancreatic cell development","alpha-catenin binding; beta-catenin binding; cadherin binding; calcium ion binding; enzyme binding; gamma-catenin binding; identical protein binding; metal ion binding; protein binding; protein kinase binding; protein phosphatase binding; RNA binding","adherens junction; anchoring junction; apical part of cell; apical plasma membrane; apicolateral plasma membrane; basolateral plasma membrane; catenin complex; cell junction; cell surface; cell-cell junction; collagen-containing extracellular matrix; cortical actin cytoskeleton; cytoplasm; desmosome; endoplasmic reticulum lumen; fascia adherens; focal adhesion; intercalated disc; lamellipodium; membrane; neuron projection; plasma membrane; plasma membrane raft; postsynaptic density; postsynaptic specialization membrane; presynaptic active zone membrane; sarcolemma; synapse","Extracellular matrix","cadherin 2","http://www.ncbi.nlm.nih.gov/gene/?term=1000","1000","12558",null,null,null,null,"P19022","P15116","A0A8I6A028","A0A8P0NJC1","F1SAM3","A0A1D5Q6I4","GO:0005912; GO:0070161; GO:0045177; GO:0016324; GO:0016327; GO:0016323; GO:0016342; GO:0030054; GO:0009986; GO:0005911; GO:0062023; GO:0030864; GO:0005737; GO:0030057; GO:0005788; GO:0005916; GO:0005925; GO:0014704; GO:0030027; GO:0016020; GO:0043005; GO:0005886; GO:0044853; GO:0014069; GO:0099634; GO:0048787; GO:0042383; GO:0045202","GO:0045294; GO:0008013; GO:0045296; GO:0005509; GO:0019899; GO:0045295; GO:0042802; GO:0046872; GO:0005515; GO:0019901; GO:0019903; GO:0003723","GO:0048514; GO:0007420; GO:0048854; GO:0016339; GO:0007155; GO:0016477; GO:0098609; GO:0044331; GO:0098742; GO:0007043; GO:0021987; GO:0035995; GO:0010001; GO:0007157; GO:0048872; GO:0007156; GO:0090497; GO:0090090; GO:0014032; GO:0060563; GO:0097118; GO:0097150; GO:0043410; GO:2000809; GO:0072659; GO:0060019; GO:0050770; GO:0070445; GO:1902897; GO:0051966; GO:0051146; GO:0007416; GO:0097091; GO:0021537; GO:0003323","PTHR24027:SF79","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1759|UniProtKB=P19022","P00012; P00057"]
["NDRG1 - phospho","Thr346","NDRG1","48, 46","rb",null,1,1,1,1,1,1,"# 1181",".CCP., .CD., .CP., .CSP., .DDR., .HIF., .OP., .OPA., .P53S., .SREME., .ST.",null,"PROTEIN NDRG1","cellular response to hypoxia; DNA damage response, signal transduction by p53 class mediator; mast cell activation; negative regulation of cell population proliferation; peripheral nervous system myelin maintenance; response to metal ion; signal transduction","cadherin binding; gamma-tubulin binding; microtubule binding; protein binding; small GTPase binding","adherens junction; centrosome; cytoplasm; cytoskeleton; cytosol; extracellular exosome; membrane; microtubule; microtubule cytoskeleton; microtubule organizing center; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome membrane","Tumor supressor","N-myc downstream regulated 1","http://www.ncbi.nlm.nih.gov/gene/?term=10397","10397","17988","299923",null,null,"697752","Q92597","Q62433","Q6JE36","A0A8I3N848","A0A287BKE2","F6SHZ8","GO:0005912; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0016020; GO:0005874; GO:0015630; GO:0005815; GO:0005634; GO:0048471; GO:0005886; GO:0055038","GO:0045296; GO:0043015; GO:0008017; GO:0005515; GO:0031267","GO:0071456; GO:0030330; GO:0045576; GO:0008285; GO:0032287; GO:0010038; GO:0007165","PTHR11034:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7679|UniProtKB=Q92597"]
["Neo-P-transferase 2",null,null,"30","ms",null,4,4,"n/a","n/a","n/a","n/a","# 2714",null,null,null,null,null,null,"Antibiotic resistance",null,null,null,null,null,null,null,null,"n.a."]
["Neuroglycan C",null,"CSPG5","150-120","ms",null,7,7,"n/a","n/a","n/a","n/a","# 0523",".CSP., .OPA., .ST.",null,"CHONDROITIN SULFATE PROTEOGLYCAN 5","axon regeneration; cell differentiation; cell projection morphogenesis; cytoskeleton organization; glial cell projection elongation; intracellular transport; modulation of chemical synaptic transmission; nervous system development; positive regulation of substrate adhesion-dependent cell spreading; regulation of synaptic vesicle exocytosis; signal transduction; trans-synaptic signaling, modulating synaptic transmission","growth factor activity; protein binding","cell surface; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular region; GABA-ergic synapse; glutamatergic synapse; Golgi apparatus; Golgi lumen; Golgi membrane; Golgi-associated vesicle membrane; lysosomal lumen; membrane; plasma membrane; postsynaptic membrane; synapse; synaptic membrane","Differentiation","chondroitin sulfate proteoglycan 5","http://www.ncbi.nlm.nih.gov/gene/?term=10675","10675","29873","50568",null,null,null,"O95196","Q71M36","Q9ERQ6","A0A8P0SHQ4",null,"F7BKT3","GO:0009986; GO:0005783; GO:0005789; GO:0005576; GO:0098982; GO:0098978; GO:0005794; GO:0005796; GO:0000139; GO:0030660; GO:0043202; GO:0016020; GO:0005886; GO:0045211; GO:0045202; GO:0097060","GO:0008083; GO:0005515","GO:0031103; GO:0030154; GO:0048858; GO:0007010; GO:0106091; GO:0046907; GO:0050804; GO:0007399; GO:1900026; GO:2000300; GO:0007165; GO:0099550","PTHR15381:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2467|UniProtKB=O95196"]
["NF-kappaB p65",null,"RELA","70","rb",null,1,2,7,8,6,7,"# 0205",".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CSP., .DI., .DRR., .GPCR., .GPROT., .HEPB., .HIF., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","Gonadotropin releasing hormone receptor pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR P65","animal organ morphogenesis; cellular defense response; cellular response to angiotensin; cellular response to hepatocyte growth factor stimulus; cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; cellular response to nicotine; cellular response to peptidoglycan; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; chromatin organization; cytokine-mediated signaling pathway; defense response; defense response to tumor cell; defense response to virus; DNA-templated transcription; hair follicle development; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; interleukin-1-mediated signaling pathway; liver development; negative regulation of apoptotic process; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of macromolecule metabolic process; negative regulation of miRNA transcription; negative regulation of NIK/NF-kappaB signaling; negative regulation of protein catabolic process; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; neuropeptide signaling pathway; NIK/NF-kappaB signaling; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of amyloid-beta formation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-12 production; positive regulation of interleukin-8 production; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of miRNA metabolic process; positive regulation of miRNA transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of T cell receptor signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; postsynapse to nucleus signaling pathway; protein catabolic process; regulation of DNA-templated transcription; regulation of DNA-templated transcription in response to stress; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; regulation of transcription by RNA polymerase II; response to bacterium; response to cytokine; response to interleukin-1; response to muramyl dipeptide; response to muscle stretch; response to organic substance; response to UV-B; tumor necrosis factor-mediated signaling pathway","actinin binding; ankyrin repeat binding; chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone deacetylase binding; identical protein binding; NF-kappaB binding; peptide binding; phosphate ion binding; protein binding; protein homodimerization activity; protein kinase binding; protein N-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coactivator binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; glutamatergic synapse; NF-kappaB complex; NF-kappaB p50/p65 complex; nucleolus; nucleoplasm; nucleus; transcription regulator complex","NFkB signaling","RELA proto-oncogene, NF-kB subunit","http://www.ncbi.nlm.nih.gov/gene/?term=5970","5970","19697",null,"483729",null,null,"Q04206","Q04207","A0A8I5ZMV7","A0A8I3P3H3","A0A286ZJ10","F6QZH6","GO:0000785; GO:0005737; GO:0005829; GO:0098978; GO:0071159; GO:0035525; GO:0005730; GO:0005654; GO:0005634; GO:0005667","GO:0042805; GO:0071532; GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0019899; GO:0140296; GO:0042826; GO:0042802; GO:0051059; GO:0042277; GO:0042301; GO:0005515; GO:0042803; GO:0019901; GO:0047485; GO:0000978; GO:0000979; GO:0000977; GO:0043565; GO:0000976; GO:0001223; GO:0031625","GO:0009887; GO:0006968; GO:1904385; GO:0035729; GO:0070301; GO:0071347; GO:0071354; GO:0071222; GO:0071223; GO:0071316; GO:0071224; GO:0071356; GO:0035924; GO:0006325; GO:0019221; GO:0006952; GO:0002357; GO:0051607; GO:0006351; GO:0001942; GO:0007249; GO:0006954; GO:0045087; GO:0070498; GO:0001889; GO:0043066; GO:0045892; GO:2001237; GO:0010605; GO:1902894; GO:1901223; GO:0042177; GO:0033234; GO:0000122; GO:0007218; GO:0038061; GO:0070431; GO:1902004; GO:0008284; GO:0045893; GO:0010628; GO:0043123; GO:0032735; GO:0032757; GO:1904996; GO:2000630; GO:1902895; GO:0051092; GO:1901224; GO:0050862; GO:0045944; GO:1901522; GO:0099527; GO:0030163; GO:0006355; GO:0043620; GO:0050727; GO:1901222; GO:0006357; GO:0009617; GO:0034097; GO:0070555; GO:0032495; GO:0035994; GO:0010033; GO:0010224; GO:0033209","PTHR24169:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9955|UniProtKB=Q04206","P06664; P00054; P00031; P00006"]
["NF-kappaB p65 - phospho","Ser276","RELA","80, 65","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0464",".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CSP., .DI., .DRR., .GPCR., .GPROT., .HEPB., .HIF., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","Gonadotropin releasing hormone receptor pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR P65","animal organ morphogenesis; cellular defense response; cellular response to angiotensin; cellular response to hepatocyte growth factor stimulus; cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; cellular response to nicotine; cellular response to peptidoglycan; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; chromatin organization; cytokine-mediated signaling pathway; defense response; defense response to tumor cell; defense response to virus; DNA-templated transcription; hair follicle development; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; interleukin-1-mediated signaling pathway; liver development; negative regulation of apoptotic process; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of macromolecule metabolic process; negative regulation of miRNA transcription; negative regulation of NIK/NF-kappaB signaling; negative regulation of protein catabolic process; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; neuropeptide signaling pathway; NIK/NF-kappaB signaling; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of amyloid-beta formation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-12 production; positive regulation of interleukin-8 production; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of miRNA metabolic process; positive regulation of miRNA transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of T cell receptor signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; postsynapse to nucleus signaling pathway; protein catabolic process; regulation of DNA-templated transcription; regulation of DNA-templated transcription in response to stress; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; regulation of transcription by RNA polymerase II; response to bacterium; response to cytokine; response to interleukin-1; response to muramyl dipeptide; response to muscle stretch; response to organic substance; response to UV-B; tumor necrosis factor-mediated signaling pathway","actinin binding; ankyrin repeat binding; chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone deacetylase binding; identical protein binding; NF-kappaB binding; peptide binding; phosphate ion binding; protein binding; protein homodimerization activity; protein kinase binding; protein N-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coactivator binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; glutamatergic synapse; NF-kappaB complex; NF-kappaB p50/p65 complex; nucleolus; nucleoplasm; nucleus; transcription regulator complex","NFkB signaling","RELA proto-oncogene, NF-kB subunit","http://www.ncbi.nlm.nih.gov/gene/?term=5970","5970","19697",null,"483729",null,null,"Q04206","Q04207","A0A8I5ZMV7","A0A8I3P3H3","A0A286ZJ10","F6QZH6","GO:0000785; GO:0005737; GO:0005829; GO:0098978; GO:0071159; GO:0035525; GO:0005730; GO:0005654; GO:0005634; GO:0005667","GO:0042805; GO:0071532; GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0019899; GO:0140296; GO:0042826; GO:0042802; GO:0051059; GO:0042277; GO:0042301; GO:0005515; GO:0042803; GO:0019901; GO:0047485; GO:0000978; GO:0000979; GO:0000977; GO:0043565; GO:0000976; GO:0001223; GO:0031625","GO:0009887; GO:0006968; GO:1904385; GO:0035729; GO:0070301; GO:0071347; GO:0071354; GO:0071222; GO:0071223; GO:0071316; GO:0071224; GO:0071356; GO:0035924; GO:0006325; GO:0019221; GO:0006952; GO:0002357; GO:0051607; GO:0006351; GO:0001942; GO:0007249; GO:0006954; GO:0045087; GO:0070498; GO:0001889; GO:0043066; GO:0045892; GO:2001237; GO:0010605; GO:1902894; GO:1901223; GO:0042177; GO:0033234; GO:0000122; GO:0007218; GO:0038061; GO:0070431; GO:1902004; GO:0008284; GO:0045893; GO:0010628; GO:0043123; GO:0032735; GO:0032757; GO:1904996; GO:2000630; GO:1902895; GO:0051092; GO:1901224; GO:0050862; GO:0045944; GO:1901522; GO:0099527; GO:0030163; GO:0006355; GO:0043620; GO:0050727; GO:1901222; GO:0006357; GO:0009617; GO:0034097; GO:0070555; GO:0032495; GO:0035994; GO:0010033; GO:0010224; GO:0033209","PTHR24169:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9955|UniProtKB=Q04206","P06664; P00054; P00031; P00006"]
["NF-kappaB p65 - phospho","Ser468","RELA","65","rb",null,1.1000000000000001,7,8,8,8,8,"# 2062",".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CSP., .DI., .DRR., .GPCR., .GPROT., .HEPB., .HIF., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","Gonadotropin releasing hormone receptor pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR P65","animal organ morphogenesis; cellular defense response; cellular response to angiotensin; cellular response to hepatocyte growth factor stimulus; cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; cellular response to nicotine; cellular response to peptidoglycan; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; chromatin organization; cytokine-mediated signaling pathway; defense response; defense response to tumor cell; defense response to virus; DNA-templated transcription; hair follicle development; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; interleukin-1-mediated signaling pathway; liver development; negative regulation of apoptotic process; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of macromolecule metabolic process; negative regulation of miRNA transcription; negative regulation of NIK/NF-kappaB signaling; negative regulation of protein catabolic process; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; neuropeptide signaling pathway; NIK/NF-kappaB signaling; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of amyloid-beta formation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-12 production; positive regulation of interleukin-8 production; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of miRNA metabolic process; positive regulation of miRNA transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of T cell receptor signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; postsynapse to nucleus signaling pathway; protein catabolic process; regulation of DNA-templated transcription; regulation of DNA-templated transcription in response to stress; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; regulation of transcription by RNA polymerase II; response to bacterium; response to cytokine; response to interleukin-1; response to muramyl dipeptide; response to muscle stretch; response to organic substance; response to UV-B; tumor necrosis factor-mediated signaling pathway","actinin binding; ankyrin repeat binding; chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone deacetylase binding; identical protein binding; NF-kappaB binding; peptide binding; phosphate ion binding; protein binding; protein homodimerization activity; protein kinase binding; protein N-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coactivator binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; glutamatergic synapse; NF-kappaB complex; NF-kappaB p50/p65 complex; nucleolus; nucleoplasm; nucleus; transcription regulator complex","NFkB signaling","RELA proto-oncogene, NF-kB subunit","http://www.ncbi.nlm.nih.gov/gene/?term=5970","5970","19697",null,"483729",null,null,"Q04206","Q04207","A0A8I5ZMV7","A0A8I3P3H3","A0A286ZJ10","F6QZH6","GO:0000785; GO:0005737; GO:0005829; GO:0098978; GO:0071159; GO:0035525; GO:0005730; GO:0005654; GO:0005634; GO:0005667","GO:0042805; GO:0071532; GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0019899; GO:0140296; GO:0042826; GO:0042802; GO:0051059; GO:0042277; GO:0042301; GO:0005515; GO:0042803; GO:0019901; GO:0047485; GO:0000978; GO:0000979; GO:0000977; GO:0043565; GO:0000976; GO:0001223; GO:0031625","GO:0009887; GO:0006968; GO:1904385; GO:0035729; GO:0070301; GO:0071347; GO:0071354; GO:0071222; GO:0071223; GO:0071316; GO:0071224; GO:0071356; GO:0035924; GO:0006325; GO:0019221; GO:0006952; GO:0002357; GO:0051607; GO:0006351; GO:0001942; GO:0007249; GO:0006954; GO:0045087; GO:0070498; GO:0001889; GO:0043066; GO:0045892; GO:2001237; GO:0010605; GO:1902894; GO:1901223; GO:0042177; GO:0033234; GO:0000122; GO:0007218; GO:0038061; GO:0070431; GO:1902004; GO:0008284; GO:0045893; GO:0010628; GO:0043123; GO:0032735; GO:0032757; GO:1904996; GO:2000630; GO:1902895; GO:0051092; GO:1901224; GO:0050862; GO:0045944; GO:1901522; GO:0099527; GO:0030163; GO:0006355; GO:0043620; GO:0050727; GO:1901222; GO:0006357; GO:0009617; GO:0034097; GO:0070555; GO:0032495; GO:0035994; GO:0010033; GO:0010224; GO:0033209","PTHR24169:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9955|UniProtKB=Q04206","P06664; P00054; P00031; P00006"]
["NF-kappaB p65 - phospho","Ser536","RELA","65","rb",null,2,1,8,8,8,8,"# 1048",".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CSP., .DI., .DRR., .GPCR., .GPROT., .HEPB., .HIF., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","Gonadotropin releasing hormone receptor pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR P65","animal organ morphogenesis; cellular defense response; cellular response to angiotensin; cellular response to hepatocyte growth factor stimulus; cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; cellular response to nicotine; cellular response to peptidoglycan; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; chromatin organization; cytokine-mediated signaling pathway; defense response; defense response to tumor cell; defense response to virus; DNA-templated transcription; hair follicle development; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; interleukin-1-mediated signaling pathway; liver development; negative regulation of apoptotic process; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of macromolecule metabolic process; negative regulation of miRNA transcription; negative regulation of NIK/NF-kappaB signaling; negative regulation of protein catabolic process; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; neuropeptide signaling pathway; NIK/NF-kappaB signaling; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of amyloid-beta formation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-12 production; positive regulation of interleukin-8 production; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of miRNA metabolic process; positive regulation of miRNA transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of T cell receptor signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; postsynapse to nucleus signaling pathway; protein catabolic process; regulation of DNA-templated transcription; regulation of DNA-templated transcription in response to stress; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; regulation of transcription by RNA polymerase II; response to bacterium; response to cytokine; response to interleukin-1; response to muramyl dipeptide; response to muscle stretch; response to organic substance; response to UV-B; tumor necrosis factor-mediated signaling pathway","actinin binding; ankyrin repeat binding; chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone deacetylase binding; identical protein binding; NF-kappaB binding; peptide binding; phosphate ion binding; protein binding; protein homodimerization activity; protein kinase binding; protein N-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coactivator binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; glutamatergic synapse; NF-kappaB complex; NF-kappaB p50/p65 complex; nucleolus; nucleoplasm; nucleus; transcription regulator complex","NFkB signaling","RELA proto-oncogene, NF-kB subunit","http://www.ncbi.nlm.nih.gov/gene/?term=5970","5970","19697",null,"483729",null,null,"Q04206","Q04207","A0A8I5ZMV7","A0A8I3P3H3","A0A286ZJ10","F6QZH6","GO:0000785; GO:0005737; GO:0005829; GO:0098978; GO:0071159; GO:0035525; GO:0005730; GO:0005654; GO:0005634; GO:0005667","GO:0042805; GO:0071532; GO:0003682; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0019899; GO:0140296; GO:0042826; GO:0042802; GO:0051059; GO:0042277; GO:0042301; GO:0005515; GO:0042803; GO:0019901; GO:0047485; GO:0000978; GO:0000979; GO:0000977; GO:0043565; GO:0000976; GO:0001223; GO:0031625","GO:0009887; GO:0006968; GO:1904385; GO:0035729; GO:0070301; GO:0071347; GO:0071354; GO:0071222; GO:0071223; GO:0071316; GO:0071224; GO:0071356; GO:0035924; GO:0006325; GO:0019221; GO:0006952; GO:0002357; GO:0051607; GO:0006351; GO:0001942; GO:0007249; GO:0006954; GO:0045087; GO:0070498; GO:0001889; GO:0043066; GO:0045892; GO:2001237; GO:0010605; GO:1902894; GO:1901223; GO:0042177; GO:0033234; GO:0000122; GO:0007218; GO:0038061; GO:0070431; GO:1902004; GO:0008284; GO:0045893; GO:0010628; GO:0043123; GO:0032735; GO:0032757; GO:1904996; GO:2000630; GO:1902895; GO:0051092; GO:1901224; GO:0050862; GO:0045944; GO:1901522; GO:0099527; GO:0030163; GO:0006355; GO:0043620; GO:0050727; GO:1901222; GO:0006357; GO:0009617; GO:0034097; GO:0070555; GO:0032495; GO:0035994; GO:0010033; GO:0010224; GO:0033209","PTHR24169:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9955|UniProtKB=Q04206","P06664; P00054; P00031; P00006"]
["NF-κB p100/p52",null,"NFKB2","120, 52","rb",null,2,5,1,1,3,3,"# 2587",".APO., .BCR., .BRC., .CANCER., .CANPTHW., .CD., .CSP., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .NFKB., .OP., .OPA., .OT., .RTK., .ST., .TCR., .TOLL., .TRASR.","T cell activation; B cell activation; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT","extracellular matrix organization; follicular dendritic cell differentiation; germinal center formation; negative regulation of macromolecule metabolic process; NIK/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; rhythmic process; signal transduction; spleen development","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","Bcl3/NF-kappaB2 complex; chromatin; cytoplasm; cytosol; NF-kappaB complex; nucleoplasm; nucleus","NFkB signaling","nuclear factor kappa B subunit 2","http://www.ncbi.nlm.nih.gov/gene/?term=4791","4791","18034",null,"486858",null,null,"Q00653","Q9WTK5","A0A8I6G6F3","A0A8I3PK60","F1S861","F7GVU6","GO:0033257; GO:0000785; GO:0005737; GO:0005829; GO:0071159; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0000978; GO:1990837","GO:0030198; GO:0002268; GO:0002467; GO:0010605; GO:0038061; GO:0045944; GO:0006355; GO:0006357; GO:0048511; GO:0007165; GO:0048536","PTHR24169:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7795|UniProtKB=Q00653","P00053; P00010; P00054; P00031; P00006"]
["NF-κB p105/p50",null,"NFKB1","120, 50","rb",null,2,2,1,2,2,1,"# 1913",".ALZ., .AML., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CD., .CML., .CSP., .DEV., .DI., .DRR., .GPCR., .HEPB., .HIF., .IMFR., .IMUF., .IMUR., .INFM., .INS., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR., .WNT.","T cell activation; B cell activation; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT","apoptotic process; B cell receptor signaling pathway; cellular response to angiotensin; cellular response to dsRNA; cellular response to interleukin-1; cellular response to interleukin-17; cellular response to interleukin-6; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to nicotine; cellular response to tumor necrosis factor; cellular response to virus; gene expression; inflammatory response; JNK cascade; mammary gland involution; MAPK cascade; negative regulation of apoptotic process; negative regulation of calcidiol 1-monooxygenase activity; negative regulation of cholesterol transport; negative regulation of cytokine production; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of interleukin-12 production; negative regulation of macromolecule metabolic process; negative regulation of protein metabolic process; negative regulation of transcription by RNA polymerase II; negative regulation of vitamin D biosynthetic process; positive regulation of canonical Wnt signaling pathway; positive regulation of DNA-templated transcription; positive regulation of hyaluronan biosynthetic process; positive regulation of lipid storage; positive regulation of macrophage derived foam cell differentiation; positive regulation of miRNA metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to muscle stretch; signal transduction; transcription by RNA polymerase II","actinin binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coregulator activity","chromatin; cytoplasm; cytosol; extracellular region; I-kappaB/NF-kappaB complex; mitochondrion; NF-kappaB complex; nucleoplasm; nucleus; secretory granule lumen; specific granule lumen","NFkB signaling","nuclear factor kappa B subunit 1","http://www.ncbi.nlm.nih.gov/gene/?term=4790","4790","18033",null,"442859",null,null,"P19838","P25799","A0A8I5ZTP7","Q6F3J0",null,"A0A5F8A1L5","GO:0000785; GO:0005737; GO:0005829; GO:0005576; GO:0033256; GO:0005739; GO:0071159; GO:0005654; GO:0005634; GO:0034774; GO:0035580","GO:0042805; GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0042802; GO:0005515; GO:0000978; GO:0000977; GO:0043565; GO:0000976; GO:0003712","GO:0006915; GO:0050853; GO:1904385; GO:0071359; GO:0071347; GO:0097398; GO:0071354; GO:0071222; GO:0071260; GO:0071316; GO:0071356; GO:0098586; GO:0010467; GO:0006954; GO:0007254; GO:0060056; GO:0000165; GO:0043066; GO:0010956; GO:0032375; GO:0001818; GO:0045892; GO:0010629; GO:0050728; GO:0032695; GO:0010605; GO:0051248; GO:0000122; GO:0010957; GO:0090263; GO:0045893; GO:1900127; GO:0010884; GO:0010744; GO:2000630; GO:0045944; GO:0060261; GO:0006355; GO:0006357; GO:0035994; GO:0007165; GO:0006366","PTHR24169:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7794|UniProtKB=P19838","P00053; P00010; P00054; P00031; P00006"]
["NIK (NF-κB inducing Kinase)",null,"MAP3K14","125","rb",null,2,2.1,8,8,8,8,"# 0668",".APO., .CCKR., .CD., .CSP., .DI., .HUNT., .IMU., .IMUF., .IMUR., .INT., .MAPK., .NFKB., .OP., .OPA., .RTK., .ST., .TCR., .TNF., .VIR.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Huntington disease; Integrin signalling pathway; Apoptosis signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14","cellular response to mechanical stimulus; defense response to virus; I-kappaB kinase/NF-kappaB signaling; immune response; MAPK cascade; NIK/NF-kappaB signaling; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein phosphorylation","ATP binding; kinase activity; MAP kinase kinase kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; fibrillar center; intracellular membrane-bounded organelle; nucleoplasm","NFkB signaling","mitogen-activated protein kinase kinase kinase 14","http://www.ncbi.nlm.nih.gov/gene/?term=9020","9020","53859","360640",null,null,"716258","Q99558","Q9WUL6","D3ZTD1","A0A8I3MS86","F1RR25","F7B742","GO:0005737; GO:0005829; GO:0001650; GO:0043231; GO:0005654","GO:0005524; GO:0016301; GO:0004709; GO:0004704; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0071260; GO:0051607; GO:0007249; GO:0006955; GO:0000165; GO:0038061; GO:0016310; GO:0043123; GO:0006468","PTHR48016:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6853|UniProtKB=Q99558","P06959; P06664; P00029; P00034; P00006"]
["NIT2",null,"NIT2","31","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2986",null,null,"OMEGA-AMIDASE NIT2","asparagine metabolic process; glutamine metabolic process; nitrogen compound metabolic process; oxaloacetate metabolic process","2-oxoglutaramate amidase activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; omega-amidase activity","centrosome; cytoplasm; cytosol; extracellular exosome; extracellular region; specific granule lumen; tertiary granule lumen",null,"nitrilase family member 2","http://www.ncbi.nlm.nih.gov/gene/?term=56954","56954","52633",null,null,null,null,"Q9NQR4","Q9JHW2","A0A8I5YCH4","A0A8I3NV28","A0A5G2RGN4","A0A1D5QLX2","GO:0005813; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:0035580; GO:1904724","GO:0106008; GO:0016787; GO:0016811; GO:0050152","GO:0006528; GO:0006541; GO:0006807; GO:0006107","PTHR23088:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=29878|UniProtKB=Q9NQR4"]
["Nitro-tyrosines",null,null,"n.a.","rb",null,2,2,1,1,1,1,"# 1578",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"n.a."]
["NLRP3 (NALP3)",null,"NLRP3","118","ms",null,4,4,4,4,4,4,"# 1621",".APO., .CD., .CSP., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .ST., .TRASR., .VIR.",null,"NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3","apoptotic process; cellular response to lipopolysaccharide; cellular response to virus; defense response; detection of biotic stimulus; immune system process; inflammatory response; innate immune response; negative regulation of acute inflammatory response; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of NF-kappaB transcription factor activity; negative regulation of NIK/NF-kappaB signaling; NLRP3 inflammasome complex assembly; osmosensory signaling pathway; pattern recognition receptor signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of inflammatory response; positive regulation of interleukin-1 beta production; positive regulation of interleukin-4 production; positive regulation of NF-kappaB transcription factor activity; positive regulation of T-helper 2 cell cytokine production; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of type 2 immune response; protein homooligomerization; pyroptosis; regulation of inflammatory response; signal transduction","ADP binding; ATP binding; ATP hydrolysis activity; DNA-binding transcription factor binding; identical protein binding; nucleotide binding; peptidoglycan binding; phosphatidylinositol phosphate binding; phosphatidylinositol-4-phosphate binding; protein binding; sequence-specific DNA binding; signaling adaptor activity; small molecule sensor activity","cytoplasm; cytosol; endoplasmic reticulum; extracellular region; Golgi apparatus; Golgi membrane; inflammasome complex; interphase microtubule organizing center; membrane; microtubule organizing center; mitochondrion; NLRP3 inflammasome complex; nucleus","Apoptosis","NLR family pyrin domain containing 3","http://www.ncbi.nlm.nih.gov/gene/?term=114548","114548",null,null,null,null,null,"Q96P20",null,null,null,null,null,"GO:0005737; GO:0005829; GO:0005783; GO:0005576; GO:0005794; GO:0000139; GO:0061702; GO:0031021; GO:0016020; GO:0005815; GO:0005739; GO:0072559; GO:0005634","GO:0043531; GO:0005524; GO:0016887; GO:0140297; GO:0042802; GO:0000166; GO:0042834; GO:1901981; GO:0070273; GO:0005515; GO:0043565; GO:0035591; GO:0140299","GO:0006915; GO:0071222; GO:0098586; GO:0006952; GO:0009595; GO:0002376; GO:0006954; GO:0045087; GO:0002674; GO:0050728; GO:0032691; GO:0032088; GO:1901223; GO:0044546; GO:0007231; GO:0002221; GO:0043280; GO:0050729; GO:0032731; GO:0032753; GO:0051092; GO:2000553; GO:0045630; GO:0045944; GO:0002830; GO:0051260; GO:0070269; GO:0050727; GO:0007165","PTHR45690:SF19","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16400|UniProtKB=Q96P20"]
["NNMT",null,"NNMT","30","ms",null,2,5,8,7,5,5,"# 0623",".DRR., .OP., .OT.","Adrenaline and noradrenaline biosynthesis","NICOTINAMIDE N-METHYLTRANSFERASE","animal organ regeneration; methylation; NAD biosynthesis via nicotinamide riboside salvage pathway; nicotinamide metabolic process; positive regulation of gluconeogenesis; positive regulation of protein deacetylation; regulation of histone H3-K4 methylation; regulation of histone methylation; regulation of polyamine biosynthetic process; response to organonitrogen compound; response to xenobiotic stimulus","methyltransferase activity; nicotinamide N-methyltransferase activity; N-methyltransferase activity; pyridine N-methyltransferase activity; transferase activity","cytoplasm; cytosol",null,"nicotinamide N-methyltransferase","http://www.ncbi.nlm.nih.gov/gene/?term=4837","4837","18113",null,null,null,"695185","P40261","O55239","A0A8I6A6E7",null,"F1SM63","F7ERX8","GO:0005737; GO:0005829","GO:0008168; GO:0008112; GO:0008170; GO:0030760; GO:0016740","GO:0031100; GO:0032259; GO:0034356; GO:0006769; GO:0045722; GO:0090312; GO:0051569; GO:0031060; GO:0010967; GO:0010243; GO:0009410","PTHR10867:SF32","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7861|UniProtKB=P40261","P00001"]
["NNMT",null,"NNMT","30","rb",null,2,6,"n/a","n/a","n/a","n/a","# 1994",".DRR., .OP., .OT.","Adrenaline and noradrenaline biosynthesis","NICOTINAMIDE N-METHYLTRANSFERASE","animal organ regeneration; methylation; NAD biosynthesis via nicotinamide riboside salvage pathway; nicotinamide metabolic process; positive regulation of gluconeogenesis; positive regulation of protein deacetylation; regulation of histone H3-K4 methylation; regulation of histone methylation; regulation of polyamine biosynthetic process; response to organonitrogen compound; response to xenobiotic stimulus","methyltransferase activity; nicotinamide N-methyltransferase activity; N-methyltransferase activity; pyridine N-methyltransferase activity; transferase activity","cytoplasm; cytosol",null,"nicotinamide N-methyltransferase","http://www.ncbi.nlm.nih.gov/gene/?term=4837","4837","18113",null,null,null,"695185","P40261","O55239","A0A8I6A6E7",null,"F1SM63","F7ERX8","GO:0005737; GO:0005829","GO:0008168; GO:0008112; GO:0008170; GO:0030760; GO:0016740","GO:0031100; GO:0032259; GO:0034356; GO:0006769; GO:0045722; GO:0090312; GO:0051569; GO:0031060; GO:0010967; GO:0010243; GO:0009410","PTHR10867:SF32","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7861|UniProtKB=P40261","P00001"]
["NOS (eNOS)",null,"NOS3","140","ms",null,7,7,"n/a","n/a","n/a","n/a","# 1534",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .ENDO., .HIF., .INS., .INT., .NOTCH., .OP., .OPA., .OT., .PI3K., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS.","VEGF signaling pathway; Interleukin signaling pathway; Angiogenesis; Endothelin signaling pathway; PI3 kinase pathway","NITRIC OXIDE SYNTHASE, ENDOTHELIAL","angiogenesis; aortic valve morphogenesis; arginine catabolic process; blood vessel diameter maintenance; blood vessel remodeling; calcium ion transport; cell redox homeostasis; cellular biosynthetic process; endocardial cushion morphogenesis; endothelial cell migration; establishment of localization in cell; homeostasis of number of cells within a tissue; in utero embryonic development; lipopolysaccharide-mediated signaling pathway; lung development; mitochondrion organization; negative regulation of biomineral tissue development; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of cell population proliferation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of hydrolase activity; negative regulation of muscle hyperplasia; negative regulation of platelet activation; negative regulation of potassium ion transport; negative regulation of smooth muscle cell proliferation; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; ovulation from ovarian follicle; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of gene expression; positive regulation of guanylate cyclase activity; positive regulation of Notch signaling pathway; potassium ion transport; pulmonary valve morphogenesis; regulation of blood pressure; regulation of nervous system process; regulation of sodium ion transport; regulation of systemic arterial blood pressure by endothelin; regulation of the force of heart contraction by chemical signal; removal of superoxide radicals; response to fluid shear stress; response to heat; response to hormone; response to lipopolysaccharide; smooth muscle hyperplasia; vasodilation; ventricular septum morphogenesis","actin monomer binding; arginine binding; cadmium ion binding; calmodulin binding; flavin adenine dinucleotide binding; FMN binding; heme binding; metal ion binding; NADP binding; nitric-oxide synthase activity; oxidoreductase activity; protein binding; scaffold protein binding; tetrahydrobiopterin binding","caveola; cytoplasm; cytoskeleton; cytosol; endocytic vesicle membrane; Golgi apparatus; Golgi membrane; membrane; nucleus; plasma membrane; vesicle membrane","Akt signaling","nitric oxide synthase 3","http://www.ncbi.nlm.nih.gov/gene/?term=4846","4846","18127",null,null,null,"714231","P29474","P70313","A0A8I6A2Y1","A0A8P0N7H0","A0A480KWC4","F6WEB2","GO:0005901; GO:0005737; GO:0005856; GO:0005829; GO:0030666; GO:0005794; GO:0000139; GO:0016020; GO:0005634; GO:0005886; GO:0012506","GO:0003785; GO:0034618; GO:0046870; GO:0005516; GO:0050660; GO:0010181; GO:0020037; GO:0046872; GO:0050661; GO:0004517; GO:0016491; GO:0005515; GO:0097110; GO:0034617","GO:0001525; GO:0003180; GO:0006527; GO:0097746; GO:0001974; GO:0006816; GO:0045454; GO:0044249; GO:0003203; GO:0043542; GO:0051649; GO:0048873; GO:0001701; GO:0031663; GO:0030324; GO:0007005; GO:0070168; GO:0045776; GO:0051926; GO:0008285; GO:1902042; GO:0051346; GO:0014740; GO:0010544; GO:0043267; GO:0048662; GO:0006809; GO:0007263; GO:0001542; GO:0045766; GO:0043536; GO:0010628; GO:0031284; GO:0045747; GO:0006813; GO:0003184; GO:0008217; GO:0031644; GO:0002028; GO:0003100; GO:0003057; GO:0019430; GO:0034405; GO:0009408; GO:0009725; GO:0032496; GO:0014806; GO:0042311; GO:0060412","PTHR19384:SF66","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7876|UniProtKB=P29474","P00056; P00036; P00005; P00019; P00048"]
["NOS (iNOS)",null,"NOS2","130","rb",null,6,7,"n/a","n/a","n/a","n/a","# 1579",".ALZ., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .DI., .DRR., .HIF., .IIR., .IMFR., .IMUR., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SCLC., .SREME., .ST., .TRASR.","PI3 kinase pathway","NITRIC OXIDE SYNTHASE, INDUCIBLE","arginine catabolic process; cell redox homeostasis; cellular biosynthetic process; cellular response to lipopolysaccharide; cellular response to type II interferon; cellular response to xenobiotic stimulus; circadian rhythm; defense response to bacterium; defense response to Gram-negative bacterium; inflammatory response; innate immune response in mucosa; negative regulation of blood pressure; negative regulation of gene expression; negative regulation of protein catabolic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of guanylate cyclase activity; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of killing of cells of another organism; positive regulation of leukocyte mediated cytotoxicity; prostaglandin secretion; regulation of cell population proliferation; regulation of cellular respiration; regulation of cytokine production involved in inflammatory response; regulation of insulin secretion; response to bacterium; response to hormone; response to hypoxia; response to lipopolysaccharide; superoxide metabolic process","arginine binding; calmodulin binding; flavin adenine dinucleotide binding; FMN binding; heme binding; metal ion binding; NADP binding; nitric-oxide synthase activity; oxidoreductase activity; protein binding; protein homodimerization activity; tetrahydrobiopterin binding","cortical cytoskeleton; cytoplasm; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; peroxisomal matrix; peroxisome; plasma membrane; vesicle membrane",null,"nitric oxide synthase 2","http://www.ncbi.nlm.nih.gov/gene/?term=4843","4843","18126",null,null,null,null,"P35228","P29477","A0A8I6AAZ6","A0A8I3NRW4","A0A286ZYB6","A0A5F8AQS9","GO:0030863; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0048471; GO:0005782; GO:0005777; GO:0005886; GO:0012506","GO:0034618; GO:0005516; GO:0050660; GO:0010181; GO:0020037; GO:0046872; GO:0050661; GO:0004517; GO:0016491; GO:0005515; GO:0042803; GO:0034617","GO:0006527; GO:0045454; GO:0044249; GO:0071222; GO:0071346; GO:0071466; GO:0007623; GO:0042742; GO:0050829; GO:0006954; GO:0002227; GO:0045776; GO:0010629; GO:0042177; GO:0006809; GO:0007263; GO:0018119; GO:0031284; GO:0032755; GO:0032757; GO:0051712; GO:0001912; GO:0032310; GO:0042127; GO:0043457; GO:1900015; GO:0050796; GO:0009617; GO:0009725; GO:0001666; GO:0032496; GO:0006801","PTHR19384:SF56","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7873|UniProtKB=P35228","P00048"]
["NOS (pan)",null,"NOS2, NOS3, NOS1","160, 140, 130","rb",null,6,4,8,8,8,8,"# 1580",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .DI., .DRR., .ENDO., .HIF., .IIR., .IMFR., .IMUR., .INS., .INT., .NOTCH., .OP., .OPA., .OT., .OXS., .PI3K., .PLAT., .RTK., .SCLC., .SREME., .ST., .TRASR., .VEGFS.","PI3 kinase pathway; VEGF signaling pathway; Interleukin signaling pathway; Angiogenesis; Endothelin signaling pathway; CCKR signaling map; Gonadotropin releasing hormone receptor pathway","NITRIC OXIDE SYNTHASE, INDUCIBLE; NITRIC OXIDE SYNTHASE, ENDOTHELIAL; NITRIC OXIDE SYNTHASE, BRAIN","arginine catabolic process; cell redox homeostasis; cellular biosynthetic process; cellular response to lipopolysaccharide; cellular response to type II interferon; cellular response to xenobiotic stimulus; circadian rhythm; defense response to bacterium; defense response to Gram-negative bacterium; inflammatory response; innate immune response in mucosa; negative regulation of blood pressure; negative regulation of gene expression; negative regulation of protein catabolic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of guanylate cyclase activity; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of killing of cells of another organism; positive regulation of leukocyte mediated cytotoxicity; prostaglandin secretion; regulation of cell population proliferation; regulation of cellular respiration; regulation of cytokine production involved in inflammatory response; regulation of insulin secretion; response to bacterium; response to hormone; response to hypoxia; response to lipopolysaccharide; superoxide metabolic process; angiogenesis; aortic valve morphogenesis; blood vessel diameter maintenance; blood vessel remodeling; calcium ion transport; endocardial cushion morphogenesis; endothelial cell migration; establishment of localization in cell; homeostasis of number of cells within a tissue; in utero embryonic development; lipopolysaccharide-mediated signaling pathway; lung development; mitochondrion organization; negative regulation of biomineral tissue development; negative regulation of calcium ion transport; negative regulation of cell population proliferation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of hydrolase activity; negative regulation of muscle hyperplasia; negative regulation of platelet activation; negative regulation of potassium ion transport; negative regulation of smooth muscle cell proliferation; ovulation from ovarian follicle; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of gene expression; positive regulation of Notch signaling pathway; potassium ion transport; pulmonary valve morphogenesis; regulation of blood pressure; regulation of nervous system process; regulation of sodium ion transport; regulation of systemic arterial blood pressure by endothelin; regulation of the force of heart contraction by chemical signal; removal of superoxide radicals; response to fluid shear stress; response to heat; smooth muscle hyperplasia; vasodilation; ventricular septum morphogenesis; cellular response to growth factor stimulus; multicellular organismal response to stress; muscle contraction; myoblast fusion; negative regulation of calcium ion transport into cytosol; negative regulation of serotonin uptake; neurotransmitter biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of histone acetylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of sodium ion transmembrane transport; positive regulation of the force of heart contraction; positive regulation of transcription by RNA polymerase II; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; regulation of cardiac muscle contraction; regulation of ryanodine-sensitive calcium-release channel activity; retrograde trans-synaptic signaling by nitric oxide; striated muscle contraction; xenobiotic catabolic process","arginine binding; calmodulin binding; flavin adenine dinucleotide binding; FMN binding; heme binding; metal ion binding; NADP binding; nitric-oxide synthase activity; oxidoreductase activity; protein binding; protein homodimerization activity; tetrahydrobiopterin binding; actin monomer binding; cadmium ion binding; scaffold protein binding; calcium-dependent protein binding; sodium channel regulator activity; transmembrane transporter binding","cortical cytoskeleton; cytoplasm; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; peroxisomal matrix; peroxisome; plasma membrane; vesicle membrane; caveola; cytoskeleton; endocytic vesicle membrane; Golgi apparatus; Golgi membrane; membrane; cell periphery; cell projection; dendritic spine; membrane raft; mitochondrion; photoreceptor inner segment; postsynaptic density; protein-containing complex; sarcolemma; sarcoplasmic reticulum; synapse",null,"nitric oxide synthase 2; nitric oxide synthase 3; nitric oxide synthase 1","http://www.ncbi.nlm.nih.gov/gene/?term=4843, http://www.ncbi.nlm.nih.gov/gene/?term=4846, http://www.ncbi.nlm.nih.gov/gene/?term=4842","4843, 4846, 4842","18126, 18127, 18125",null,null,null,"NA, 714231","P35228, P29474, P29475","P29477, P70313, Q9Z0J4","A0A8I6AAZ6, A0A8I6A2Y1, A0A8I5YCJ4","A0A8I3NRW4, A0A8P0N7H0, A0A8I3PT17","A0A286ZYB6, A0A480KWC4, A0A287BKF3","A0A5F8AQS9, F6WEB2, A0A5F7ZUS9","GO:0030863; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0048471; GO:0005782; GO:0005777; GO:0005886; GO:0012506; GO:0005901; GO:0005856; GO:0030666; GO:0005794; GO:0000139; GO:0016020; GO:0071944; GO:0042995; GO:0043197; GO:0045121; GO:0005739; GO:0001917; GO:0014069; GO:0032991; GO:0042383; GO:0016529; GO:0045202","GO:0034618; GO:0005516; GO:0050660; GO:0010181; GO:0020037; GO:0046872; GO:0050661; GO:0004517; GO:0016491; GO:0005515; GO:0042803; GO:0034617; GO:0003785; GO:0046870; GO:0097110; GO:0048306; GO:0017080; GO:0044325","GO:0006527; GO:0045454; GO:0044249; GO:0071222; GO:0071346; GO:0071466; GO:0007623; GO:0042742; GO:0050829; GO:0006954; GO:0002227; GO:0045776; GO:0010629; GO:0042177; GO:0006809; GO:0007263; GO:0018119; GO:0031284; GO:0032755; GO:0032757; GO:0051712; GO:0001912; GO:0032310; GO:0042127; GO:0043457; GO:1900015; GO:0050796; GO:0009617; GO:0009725; GO:0001666; GO:0032496; GO:0006801; GO:0001525; GO:0003180; GO:0097746; GO:0001974; GO:0006816; GO:0003203; GO:0043542; GO:0051649; GO:0048873; GO:0001701; GO:0031663; GO:0030324; GO:0007005; GO:0070168; GO:0051926; GO:0008285; GO:1902042; GO:0051346; GO:0014740; GO:0010544; GO:0043267; GO:0048662; GO:0001542; GO:0045766; GO:0043536; GO:0010628; GO:0045747; GO:0006813; GO:0003184; GO:0008217; GO:0031644; GO:0002028; GO:0003100; GO:0003057; GO:0019430; GO:0034405; GO:0009408; GO:0014806; GO:0042311; GO:0060412; GO:0071363; GO:0033555; GO:0006936; GO:0007520; GO:0010523; GO:0051612; GO:0042136; GO:0045893; GO:0035066; GO:0033138; GO:1902307; GO:0098735; GO:0045944; GO:1902514; GO:0055117; GO:0060314; GO:0098924; GO:0006941; GO:0042178","PTHR19384:SF56; PTHR19384:SF66; PTHR19384:SF63","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7873|UniProtKB=P35228; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7876|UniProtKB=P29474; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7872|UniProtKB=P29475","P00048; P00056; P00036; P00005; P00019; P06959; P06664"]
["Notch 1",null,"NOTCH1","300, 120","rb",null,2,8,8,8,8,8,"# 0427",".ALZ., .ANG., .APO., .BMP., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .DI., .DRR., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .NOTCH., .OP., .OT., .RAS., .RTK., .SREME., .STAT., .TCD., .TMAT., .TRASR., .VIR., .WNT.","Notch signaling pathway; Alzheimer disease-presenilin pathway; Angiogenesis","NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1","angiogenesis; animal organ regeneration; aortic valve morphogenesis; apoptotic process; apoptotic process involved in embryonic digit morphogenesis; arterial endothelial cell differentiation; astrocyte differentiation; atrioventricular node development; atrioventricular valve morphogenesis; auditory receptor cell fate commitment; axon guidance; axonogenesis; brain development; branching morphogenesis of an epithelial tube; calcium-ion regulated exocytosis; cardiac atrium morphogenesis; cardiac chamber formation; cardiac epithelial to mesenchymal transition; cardiac left ventricle morphogenesis; cardiac muscle cell myoblast differentiation; cardiac muscle cell proliferation; cardiac muscle tissue morphogenesis; cardiac right atrium morphogenesis; cardiac right ventricle formation; cardiac septum morphogenesis; cardiac vascular smooth muscle cell development; cardiac ventricle morphogenesis; cell differentiation; cell differentiation in spinal cord; cell migration involved in endocardial cushion formation; cell population proliferation; cellular response to follicle-stimulating hormone stimulus; cellular response to hypoxia; cellular response to tumor cell; cellular response to vascular endothelial growth factor stimulus; cilium assembly; collecting duct development; compartment pattern specification; coronary artery morphogenesis; coronary sinus valve morphogenesis; coronary vein morphogenesis; determination of left/right symmetry; distal tubule development; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; endocardial cell differentiation; endocardial cushion development; endocardial cushion morphogenesis; endocardium development; endocardium morphogenesis; endoderm development; epidermal cell fate specification; epidermis development; epithelial cell fate commitment; epithelial cell proliferation; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; forebrain development; foregut morphogenesis; gene expression; glial cell differentiation; glomerular mesangial cell development; growth involved in heart morphogenesis; hair follicle morphogenesis; heart development; heart looping; heart trabecula morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; immune response; in utero embryonic development; inflammatory response to antigenic stimulus; inhibition of neuroepithelial cell differentiation; interleukin-17-mediated signaling pathway; keratinocyte differentiation; left/right axis specification; liver development; lung development; mesenchymal cell development; mitral valve formation; negative regulation of anoikis; negative regulation of biomineral tissue development; negative regulation of BMP signaling pathway; negative regulation of calcium ion-dependent exocytosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy; negative regulation of catalytic activity; negative regulation of cell adhesion molecule production; negative regulation of cell death; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of cell proliferation involved in heart valve morphogenesis; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cell-substrate adhesion; negative regulation of cold-induced thermogenesis; negative regulation of collagen biosynthetic process; negative regulation of DNA-templated transcription; negative regulation of endothelial cell chemotaxis; negative regulation of epithelial cell proliferation; negative regulation of extracellular matrix constituent secretion; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of inner ear auditory receptor cell differentiation; negative regulation of myoblast differentiation; negative regulation of myotube differentiation; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; neural tube development; neuroendocrine cell differentiation; neuron differentiation; neuron fate commitment; neuronal stem cell population maintenance; Notch signaling involved in heart development; Notch signaling pathway; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; oligodendrocyte differentiation; outflow tract morphogenesis; pericardium morphogenesis; positive regulation of aorta morphogenesis; positive regulation of apoptotic process; positive regulation of apoptotic process involved in morphogenesis; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac epithelial to mesenchymal transition; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glial cell differentiation; positive regulation of keratinocyte differentiation; positive regulation of neuroblast proliferation; positive regulation of Notch signaling pathway; positive regulation of Ras protein signal transduction; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of Notch receptor target; positive regulation of viral genome replication; prostate gland epithelium morphogenesis; protein catabolic process; protein import into nucleus; pulmonary valve morphogenesis; regulation of cardioblast proliferation; regulation of cell migration; regulation of cell population proliferation; regulation of developmental process; regulation of DNA-templated transcription; regulation of epithelial cell proliferation; regulation of epithelial cell proliferation involved in prostate gland development; regulation of extracellular matrix assembly; regulation of gene expression; regulation of inner ear auditory receptor cell differentiation; regulation of neurogenesis; regulation of Notch signaling pathway; regulation of somitogenesis; regulation of stem cell proliferation; regulation of transcription by RNA polymerase II; response to corticosteroid; response to lipopolysaccharide; response to muramyl dipeptide; retinal cone cell differentiation; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; skeletal muscle cell differentiation; somatic stem cell division; spermatogenesis; sprouting angiogenesis; T-helper 17 type immune response; tissue regeneration; transcription by RNA polymerase II; tube formation; vasculogenesis involved in coronary vascular morphogenesis; venous blood vessel morphogenesis; venous endothelial cell differentiation; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis","calcium ion binding; chromatin binding; chromatin DNA binding; enzyme binding; enzyme inhibitor activity; identical protein binding; metal ion binding; Notch binding; protein binding; signaling receptor activity; transcription coactivator activity; transcription regulator activator activity; transmembrane signaling receptor activity","acrosomal vesicle; adherens junction; apical plasma membrane; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular region; Golgi apparatus; Golgi membrane; MAML1-RBP-Jkappa- ICN1 complex; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex","Development","notch receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=4851","4851","18128","25496",null,null,null,"P46531","Q01705","Q07008","A0A8I3MTK6",null,"A0A5F8AET7","GO:0001669; GO:0005912; GO:0016324; GO:0071944; GO:0009986; GO:0005737; GO:0031410; GO:0005829; GO:0005783; GO:0005789; GO:0005576; GO:0005794; GO:0000139; GO:0002193; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0043235","GO:0005509; GO:0003682; GO:0031490; GO:0019899; GO:0004857; GO:0042802; GO:0046872; GO:0005112; GO:0005515; GO:0038023; GO:0003713; GO:0140537; GO:0004888","GO:0001525; GO:0031100; GO:0003180; GO:0006915; GO:1902263; GO:0060842; GO:0048708; GO:0003162; GO:0003181; GO:0009912; GO:0007411; GO:0007409; GO:0007420; GO:0048754; GO:0017156; GO:0003209; GO:0003207; GO:0060317; GO:0003214; GO:0060379; GO:0060038; GO:0055008; GO:0003213; GO:0003219; GO:0060411; GO:0060948; GO:0003208; GO:0030154; GO:0021515; GO:0003273; GO:0008283; GO:0071372; GO:0071456; GO:0071228; GO:0035924; GO:0060271; GO:0072044; GO:0007386; GO:0060982; GO:0003182; GO:0003169; GO:0007368; GO:0072017; GO:0035116; GO:0030326; GO:0060956; GO:0003197; GO:0003203; GO:0003157; GO:0003160; GO:0007492; GO:0009957; GO:0008544; GO:0072148; GO:0050673; GO:0001837; GO:0003198; GO:0030900; GO:0007440; GO:0010467; GO:0010001; GO:0072144; GO:0003241; GO:0031069; GO:0007507; GO:0001947; GO:0061384; GO:0048873; GO:0006959; GO:0006955; GO:0001701; GO:0002437; GO:0002085; GO:0097400; GO:0030216; GO:0070986; GO:0001889; GO:0030324; GO:0014031; GO:0003192; GO:2000811; GO:0070168; GO:0030514; GO:0045955; GO:0090090; GO:0010614; GO:0043086; GO:0060354; GO:0060548; GO:0090051; GO:0008285; GO:0003252; GO:2000048; GO:0010812; GO:0120163; GO:0032966; GO:0045892; GO:2001027; GO:0050680; GO:0003332; GO:0010629; GO:0060253; GO:0045608; GO:0045662; GO:0010832; GO:0050768; GO:0045665; GO:0048715; GO:0030279; GO:0045668; GO:0046533; GO:2000974; GO:2000737; GO:0000122; GO:0021915; GO:0061101; GO:0030182; GO:0048663; GO:0097150; GO:0061314; GO:0007219; GO:0003270; GO:0048709; GO:0003151; GO:0003344; GO:1903849; GO:0043065; GO:1902339; GO:0048711; GO:0030513; GO:0062043; GO:0060045; GO:0030335; GO:0008284; GO:0045893; GO:0045603; GO:0050679; GO:0010718; GO:0070374; GO:0010628; GO:0045687; GO:0045618; GO:0002052; GO:0045747; GO:0046579; GO:0046427; GO:0045944; GO:0007221; GO:0045070; GO:0060740; GO:0030163; GO:0006606; GO:0003184; GO:0003264; GO:0030334; GO:0042127; GO:0050793; GO:0006355; GO:0050678; GO:0060768; GO:1901201; GO:0010468; GO:0045607; GO:0050767; GO:0008593; GO:0014807; GO:0072091; GO:0006357; GO:0031960; GO:0032496; GO:0032495; GO:0042670; GO:0060528; GO:0035914; GO:0048103; GO:0007283; GO:0002040; GO:0072538; GO:0042246; GO:0006366; GO:0035148; GO:0060979; GO:0048845; GO:0060843; GO:0060412; GO:0003222","PTHR45836:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7881|UniProtKB=P46531","P00045; P00004; P00005"]
["Notch 1",null,"NOTCH1","300, 120","rb",null,6,1,7,7,6,6,"# 1440",".ALZ., .ANG., .APO., .BMP., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .DI., .DRR., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .NOTCH., .OP., .OT., .RAS., .RTK., .SREME., .STAT., .TCD., .TMAT., .TRASR., .VIR., .WNT.","Notch signaling pathway; Alzheimer disease-presenilin pathway; Angiogenesis","NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1","angiogenesis; animal organ regeneration; aortic valve morphogenesis; apoptotic process; apoptotic process involved in embryonic digit morphogenesis; arterial endothelial cell differentiation; astrocyte differentiation; atrioventricular node development; atrioventricular valve morphogenesis; auditory receptor cell fate commitment; axon guidance; axonogenesis; brain development; branching morphogenesis of an epithelial tube; calcium-ion regulated exocytosis; cardiac atrium morphogenesis; cardiac chamber formation; cardiac epithelial to mesenchymal transition; cardiac left ventricle morphogenesis; cardiac muscle cell myoblast differentiation; cardiac muscle cell proliferation; cardiac muscle tissue morphogenesis; cardiac right atrium morphogenesis; cardiac right ventricle formation; cardiac septum morphogenesis; cardiac vascular smooth muscle cell development; cardiac ventricle morphogenesis; cell differentiation; cell differentiation in spinal cord; cell migration involved in endocardial cushion formation; cell population proliferation; cellular response to follicle-stimulating hormone stimulus; cellular response to hypoxia; cellular response to tumor cell; cellular response to vascular endothelial growth factor stimulus; cilium assembly; collecting duct development; compartment pattern specification; coronary artery morphogenesis; coronary sinus valve morphogenesis; coronary vein morphogenesis; determination of left/right symmetry; distal tubule development; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; endocardial cell differentiation; endocardial cushion development; endocardial cushion morphogenesis; endocardium development; endocardium morphogenesis; endoderm development; epidermal cell fate specification; epidermis development; epithelial cell fate commitment; epithelial cell proliferation; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; forebrain development; foregut morphogenesis; gene expression; glial cell differentiation; glomerular mesangial cell development; growth involved in heart morphogenesis; hair follicle morphogenesis; heart development; heart looping; heart trabecula morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; immune response; in utero embryonic development; inflammatory response to antigenic stimulus; inhibition of neuroepithelial cell differentiation; interleukin-17-mediated signaling pathway; keratinocyte differentiation; left/right axis specification; liver development; lung development; mesenchymal cell development; mitral valve formation; negative regulation of anoikis; negative regulation of biomineral tissue development; negative regulation of BMP signaling pathway; negative regulation of calcium ion-dependent exocytosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy; negative regulation of catalytic activity; negative regulation of cell adhesion molecule production; negative regulation of cell death; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of cell proliferation involved in heart valve morphogenesis; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cell-substrate adhesion; negative regulation of cold-induced thermogenesis; negative regulation of collagen biosynthetic process; negative regulation of DNA-templated transcription; negative regulation of endothelial cell chemotaxis; negative regulation of epithelial cell proliferation; negative regulation of extracellular matrix constituent secretion; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of inner ear auditory receptor cell differentiation; negative regulation of myoblast differentiation; negative regulation of myotube differentiation; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; neural tube development; neuroendocrine cell differentiation; neuron differentiation; neuron fate commitment; neuronal stem cell population maintenance; Notch signaling involved in heart development; Notch signaling pathway; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; oligodendrocyte differentiation; outflow tract morphogenesis; pericardium morphogenesis; positive regulation of aorta morphogenesis; positive regulation of apoptotic process; positive regulation of apoptotic process involved in morphogenesis; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac epithelial to mesenchymal transition; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glial cell differentiation; positive regulation of keratinocyte differentiation; positive regulation of neuroblast proliferation; positive regulation of Notch signaling pathway; positive regulation of Ras protein signal transduction; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of Notch receptor target; positive regulation of viral genome replication; prostate gland epithelium morphogenesis; protein catabolic process; protein import into nucleus; pulmonary valve morphogenesis; regulation of cardioblast proliferation; regulation of cell migration; regulation of cell population proliferation; regulation of developmental process; regulation of DNA-templated transcription; regulation of epithelial cell proliferation; regulation of epithelial cell proliferation involved in prostate gland development; regulation of extracellular matrix assembly; regulation of gene expression; regulation of inner ear auditory receptor cell differentiation; regulation of neurogenesis; regulation of Notch signaling pathway; regulation of somitogenesis; regulation of stem cell proliferation; regulation of transcription by RNA polymerase II; response to corticosteroid; response to lipopolysaccharide; response to muramyl dipeptide; retinal cone cell differentiation; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; skeletal muscle cell differentiation; somatic stem cell division; spermatogenesis; sprouting angiogenesis; T-helper 17 type immune response; tissue regeneration; transcription by RNA polymerase II; tube formation; vasculogenesis involved in coronary vascular morphogenesis; venous blood vessel morphogenesis; venous endothelial cell differentiation; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis","calcium ion binding; chromatin binding; chromatin DNA binding; enzyme binding; enzyme inhibitor activity; identical protein binding; metal ion binding; Notch binding; protein binding; signaling receptor activity; transcription coactivator activity; transcription regulator activator activity; transmembrane signaling receptor activity","acrosomal vesicle; adherens junction; apical plasma membrane; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular region; Golgi apparatus; Golgi membrane; MAML1-RBP-Jkappa- ICN1 complex; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex","Development","notch receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=4851","4851","18128","25496",null,null,null,"P46531","Q01705","Q07008","A0A8I3MTK6",null,"A0A5F8AET7","GO:0001669; GO:0005912; GO:0016324; GO:0071944; GO:0009986; GO:0005737; GO:0031410; GO:0005829; GO:0005783; GO:0005789; GO:0005576; GO:0005794; GO:0000139; GO:0002193; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0043235","GO:0005509; GO:0003682; GO:0031490; GO:0019899; GO:0004857; GO:0042802; GO:0046872; GO:0005112; GO:0005515; GO:0038023; GO:0003713; GO:0140537; GO:0004888","GO:0001525; GO:0031100; GO:0003180; GO:0006915; GO:1902263; GO:0060842; GO:0048708; GO:0003162; GO:0003181; GO:0009912; GO:0007411; GO:0007409; GO:0007420; GO:0048754; GO:0017156; GO:0003209; GO:0003207; GO:0060317; GO:0003214; GO:0060379; GO:0060038; GO:0055008; GO:0003213; GO:0003219; GO:0060411; GO:0060948; GO:0003208; GO:0030154; GO:0021515; GO:0003273; GO:0008283; GO:0071372; GO:0071456; GO:0071228; GO:0035924; GO:0060271; GO:0072044; GO:0007386; GO:0060982; GO:0003182; GO:0003169; GO:0007368; GO:0072017; GO:0035116; GO:0030326; GO:0060956; GO:0003197; GO:0003203; GO:0003157; GO:0003160; GO:0007492; GO:0009957; GO:0008544; GO:0072148; GO:0050673; GO:0001837; GO:0003198; GO:0030900; GO:0007440; GO:0010467; GO:0010001; GO:0072144; GO:0003241; GO:0031069; GO:0007507; GO:0001947; GO:0061384; GO:0048873; GO:0006959; GO:0006955; GO:0001701; GO:0002437; GO:0002085; GO:0097400; GO:0030216; GO:0070986; GO:0001889; GO:0030324; GO:0014031; GO:0003192; GO:2000811; GO:0070168; GO:0030514; GO:0045955; GO:0090090; GO:0010614; GO:0043086; GO:0060354; GO:0060548; GO:0090051; GO:0008285; GO:0003252; GO:2000048; GO:0010812; GO:0120163; GO:0032966; GO:0045892; GO:2001027; GO:0050680; GO:0003332; GO:0010629; GO:0060253; GO:0045608; GO:0045662; GO:0010832; GO:0050768; GO:0045665; GO:0048715; GO:0030279; GO:0045668; GO:0046533; GO:2000974; GO:2000737; GO:0000122; GO:0021915; GO:0061101; GO:0030182; GO:0048663; GO:0097150; GO:0061314; GO:0007219; GO:0003270; GO:0048709; GO:0003151; GO:0003344; GO:1903849; GO:0043065; GO:1902339; GO:0048711; GO:0030513; GO:0062043; GO:0060045; GO:0030335; GO:0008284; GO:0045893; GO:0045603; GO:0050679; GO:0010718; GO:0070374; GO:0010628; GO:0045687; GO:0045618; GO:0002052; GO:0045747; GO:0046579; GO:0046427; GO:0045944; GO:0007221; GO:0045070; GO:0060740; GO:0030163; GO:0006606; GO:0003184; GO:0003264; GO:0030334; GO:0042127; GO:0050793; GO:0006355; GO:0050678; GO:0060768; GO:1901201; GO:0010468; GO:0045607; GO:0050767; GO:0008593; GO:0014807; GO:0072091; GO:0006357; GO:0031960; GO:0032496; GO:0032495; GO:0042670; GO:0060528; GO:0035914; GO:0048103; GO:0007283; GO:0002040; GO:0072538; GO:0042246; GO:0006366; GO:0035148; GO:0060979; GO:0048845; GO:0060843; GO:0060412; GO:0003222","PTHR45836:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7881|UniProtKB=P46531","P00045; P00004; P00005"]
["Notch 1 - cleaved","Val1744","NOTCH1","110","rb",null,2,4,8,8,8,8,"# 0453",".ALZ., .ANG., .APO., .BMP., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .DI., .DRR., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .NOTCH., .OP., .OT., .RAS., .RTK., .SREME., .STAT., .TCD., .TMAT., .TRASR., .VIR., .WNT.","Notch signaling pathway; Alzheimer disease-presenilin pathway; Angiogenesis","NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1","angiogenesis; animal organ regeneration; aortic valve morphogenesis; apoptotic process; apoptotic process involved in embryonic digit morphogenesis; arterial endothelial cell differentiation; astrocyte differentiation; atrioventricular node development; atrioventricular valve morphogenesis; auditory receptor cell fate commitment; axon guidance; axonogenesis; brain development; branching morphogenesis of an epithelial tube; calcium-ion regulated exocytosis; cardiac atrium morphogenesis; cardiac chamber formation; cardiac epithelial to mesenchymal transition; cardiac left ventricle morphogenesis; cardiac muscle cell myoblast differentiation; cardiac muscle cell proliferation; cardiac muscle tissue morphogenesis; cardiac right atrium morphogenesis; cardiac right ventricle formation; cardiac septum morphogenesis; cardiac vascular smooth muscle cell development; cardiac ventricle morphogenesis; cell differentiation; cell differentiation in spinal cord; cell migration involved in endocardial cushion formation; cell population proliferation; cellular response to follicle-stimulating hormone stimulus; cellular response to hypoxia; cellular response to tumor cell; cellular response to vascular endothelial growth factor stimulus; cilium assembly; collecting duct development; compartment pattern specification; coronary artery morphogenesis; coronary sinus valve morphogenesis; coronary vein morphogenesis; determination of left/right symmetry; distal tubule development; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; endocardial cell differentiation; endocardial cushion development; endocardial cushion morphogenesis; endocardium development; endocardium morphogenesis; endoderm development; epidermal cell fate specification; epidermis development; epithelial cell fate commitment; epithelial cell proliferation; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; forebrain development; foregut morphogenesis; gene expression; glial cell differentiation; glomerular mesangial cell development; growth involved in heart morphogenesis; hair follicle morphogenesis; heart development; heart looping; heart trabecula morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; immune response; in utero embryonic development; inflammatory response to antigenic stimulus; inhibition of neuroepithelial cell differentiation; interleukin-17-mediated signaling pathway; keratinocyte differentiation; left/right axis specification; liver development; lung development; mesenchymal cell development; mitral valve formation; negative regulation of anoikis; negative regulation of biomineral tissue development; negative regulation of BMP signaling pathway; negative regulation of calcium ion-dependent exocytosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy; negative regulation of catalytic activity; negative regulation of cell adhesion molecule production; negative regulation of cell death; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of cell proliferation involved in heart valve morphogenesis; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cell-substrate adhesion; negative regulation of cold-induced thermogenesis; negative regulation of collagen biosynthetic process; negative regulation of DNA-templated transcription; negative regulation of endothelial cell chemotaxis; negative regulation of epithelial cell proliferation; negative regulation of extracellular matrix constituent secretion; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of inner ear auditory receptor cell differentiation; negative regulation of myoblast differentiation; negative regulation of myotube differentiation; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; neural tube development; neuroendocrine cell differentiation; neuron differentiation; neuron fate commitment; neuronal stem cell population maintenance; Notch signaling involved in heart development; Notch signaling pathway; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; oligodendrocyte differentiation; outflow tract morphogenesis; pericardium morphogenesis; positive regulation of aorta morphogenesis; positive regulation of apoptotic process; positive regulation of apoptotic process involved in morphogenesis; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac epithelial to mesenchymal transition; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glial cell differentiation; positive regulation of keratinocyte differentiation; positive regulation of neuroblast proliferation; positive regulation of Notch signaling pathway; positive regulation of Ras protein signal transduction; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of Notch receptor target; positive regulation of viral genome replication; prostate gland epithelium morphogenesis; protein catabolic process; protein import into nucleus; pulmonary valve morphogenesis; regulation of cardioblast proliferation; regulation of cell migration; regulation of cell population proliferation; regulation of developmental process; regulation of DNA-templated transcription; regulation of epithelial cell proliferation; regulation of epithelial cell proliferation involved in prostate gland development; regulation of extracellular matrix assembly; regulation of gene expression; regulation of inner ear auditory receptor cell differentiation; regulation of neurogenesis; regulation of Notch signaling pathway; regulation of somitogenesis; regulation of stem cell proliferation; regulation of transcription by RNA polymerase II; response to corticosteroid; response to lipopolysaccharide; response to muramyl dipeptide; retinal cone cell differentiation; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; skeletal muscle cell differentiation; somatic stem cell division; spermatogenesis; sprouting angiogenesis; T-helper 17 type immune response; tissue regeneration; transcription by RNA polymerase II; tube formation; vasculogenesis involved in coronary vascular morphogenesis; venous blood vessel morphogenesis; venous endothelial cell differentiation; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis","calcium ion binding; chromatin binding; chromatin DNA binding; enzyme binding; enzyme inhibitor activity; identical protein binding; metal ion binding; Notch binding; protein binding; signaling receptor activity; transcription coactivator activity; transcription regulator activator activity; transmembrane signaling receptor activity","acrosomal vesicle; adherens junction; apical plasma membrane; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular region; Golgi apparatus; Golgi membrane; MAML1-RBP-Jkappa- ICN1 complex; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex","Development","notch receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=4851","4851","18128","25496",null,null,null,"P46531","Q01705","Q07008","A0A8I3MTK6",null,"A0A5F8AET7","GO:0001669; GO:0005912; GO:0016324; GO:0071944; GO:0009986; GO:0005737; GO:0031410; GO:0005829; GO:0005783; GO:0005789; GO:0005576; GO:0005794; GO:0000139; GO:0002193; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0043235","GO:0005509; GO:0003682; GO:0031490; GO:0019899; GO:0004857; GO:0042802; GO:0046872; GO:0005112; GO:0005515; GO:0038023; GO:0003713; GO:0140537; GO:0004888","GO:0001525; GO:0031100; GO:0003180; GO:0006915; GO:1902263; GO:0060842; GO:0048708; GO:0003162; GO:0003181; GO:0009912; GO:0007411; GO:0007409; GO:0007420; GO:0048754; GO:0017156; GO:0003209; GO:0003207; GO:0060317; GO:0003214; GO:0060379; GO:0060038; GO:0055008; GO:0003213; GO:0003219; GO:0060411; GO:0060948; GO:0003208; GO:0030154; GO:0021515; GO:0003273; GO:0008283; GO:0071372; GO:0071456; GO:0071228; GO:0035924; GO:0060271; GO:0072044; GO:0007386; GO:0060982; GO:0003182; GO:0003169; GO:0007368; GO:0072017; GO:0035116; GO:0030326; GO:0060956; GO:0003197; GO:0003203; GO:0003157; GO:0003160; GO:0007492; GO:0009957; GO:0008544; GO:0072148; GO:0050673; GO:0001837; GO:0003198; GO:0030900; GO:0007440; GO:0010467; GO:0010001; GO:0072144; GO:0003241; GO:0031069; GO:0007507; GO:0001947; GO:0061384; GO:0048873; GO:0006959; GO:0006955; GO:0001701; GO:0002437; GO:0002085; GO:0097400; GO:0030216; GO:0070986; GO:0001889; GO:0030324; GO:0014031; GO:0003192; GO:2000811; GO:0070168; GO:0030514; GO:0045955; GO:0090090; GO:0010614; GO:0043086; GO:0060354; GO:0060548; GO:0090051; GO:0008285; GO:0003252; GO:2000048; GO:0010812; GO:0120163; GO:0032966; GO:0045892; GO:2001027; GO:0050680; GO:0003332; GO:0010629; GO:0060253; GO:0045608; GO:0045662; GO:0010832; GO:0050768; GO:0045665; GO:0048715; GO:0030279; GO:0045668; GO:0046533; GO:2000974; GO:2000737; GO:0000122; GO:0021915; GO:0061101; GO:0030182; GO:0048663; GO:0097150; GO:0061314; GO:0007219; GO:0003270; GO:0048709; GO:0003151; GO:0003344; GO:1903849; GO:0043065; GO:1902339; GO:0048711; GO:0030513; GO:0062043; GO:0060045; GO:0030335; GO:0008284; GO:0045893; GO:0045603; GO:0050679; GO:0010718; GO:0070374; GO:0010628; GO:0045687; GO:0045618; GO:0002052; GO:0045747; GO:0046579; GO:0046427; GO:0045944; GO:0007221; GO:0045070; GO:0060740; GO:0030163; GO:0006606; GO:0003184; GO:0003264; GO:0030334; GO:0042127; GO:0050793; GO:0006355; GO:0050678; GO:0060768; GO:1901201; GO:0010468; GO:0045607; GO:0050767; GO:0008593; GO:0014807; GO:0072091; GO:0006357; GO:0031960; GO:0032496; GO:0032495; GO:0042670; GO:0060528; GO:0035914; GO:0048103; GO:0007283; GO:0002040; GO:0072538; GO:0042246; GO:0006366; GO:0035148; GO:0060979; GO:0048845; GO:0060843; GO:0060412; GO:0003222","PTHR45836:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7881|UniProtKB=P46531","P00045; P00004; P00005"]
["Notch 2",null,"NOTCH2","300, 110","rb",null,2,1,7,8,8,8,"# 1441",".ALZ., .ANG., .APO., .BMP., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .DI., .IMFR., .IMU., .IMUR., .MAPK., .NOTCH., .OP., .OT., .RAS., .RTK., .TCD., .TMAT., .TRASR.","Notch signaling pathway; Alzheimer disease-presenilin pathway; Angiogenesis","NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2","animal organ morphogenesis; apoptotic process; atrial septum morphogenesis; atrioventricular node development; axon guidance; BMP signaling pathway; bone remodeling; cell differentiation; cell fate determination; cell population proliferation; cellular response to tumor cell; cholangiocyte proliferation; ciliary body morphogenesis; defense response to bacterium; determination of left/right symmetry; embryonic limb morphogenesis; glomerular capillary formation; heart looping; hemopoiesis; hepatocyte proliferation; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; intrahepatic bile duct development; left/right axis specification; liver development; liver morphogenesis; marginal zone B cell differentiation; morphogenesis of an epithelial sheet; multicellular organism growth; myeloid dendritic cell differentiation; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; nervous system development; Notch signaling involved in heart development; Notch signaling pathway; placenta blood vessel development; placenta development; podocyte development; positive regulation of apoptotic process; positive regulation of BMP signaling pathway; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of keratinocyte proliferation; positive regulation of osteoclast differentiation; positive regulation of Ras protein signal transduction; proximal tubule development; pulmonary valve morphogenesis; regulation of actin cytoskeleton reorganization; regulation of developmental process; regulation of DNA-templated transcription; regulation of osteoclast development; regulation of transcription by RNA polymerase II; wound healing","calcium ion binding; enzyme binding; NF-kappaB binding; protein binding; signaling receptor activity","cell surface; cilium; cytoplasm; endoplasmic reticulum membrane; extracellular region; Golgi membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex","Development","notch receptor 2","http://www.ncbi.nlm.nih.gov/gene/?term=4853","4853","18129",null,null,null,null,"Q04721","O35516","A0A1W2Q619","A0A8I3MX54","A0A5G2QPH9","F7DFJ1","GO:0009986; GO:0005929; GO:0005737; GO:0005789; GO:0005576; GO:0000139; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0043235","GO:0005509; GO:0019899; GO:0051059; GO:0005515; GO:0038023","GO:0009887; GO:0006915; GO:0060413; GO:0003162; GO:0007411; GO:0030509; GO:0046849; GO:0030154; GO:0001709; GO:0008283; GO:0071228; GO:1990705; GO:0061073; GO:0042742; GO:0007368; GO:0030326; GO:0072104; GO:0001947; GO:0030097; GO:0072574; GO:0006959; GO:0001701; GO:0002437; GO:0035622; GO:0070986; GO:0001889; GO:0072576; GO:0002315; GO:0002011; GO:0035264; GO:0043011; GO:0043066; GO:0010629; GO:0000122; GO:0007399; GO:0061314; GO:0007219; GO:0060674; GO:0001890; GO:0072015; GO:0043065; GO:0030513; GO:0008284; GO:0070374; GO:0010838; GO:0045672; GO:0046579; GO:0072014; GO:0003184; GO:2000249; GO:0050793; GO:0006355; GO:2001204; GO:0006357; GO:0042060","PTHR45836:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7882|UniProtKB=Q04721","P00045; P00004; P00005"]
["Notch 3",null,"NOTCH3","270, 90","rb",null,6,2,7,4,8,5,"# 1442",".ALZ., .ANG., .BRC., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .DEV., .DI., .NOTCH., .OP., .OT., .TCD., .TMAT., .TRASR.","Notch signaling pathway; Alzheimer disease-presenilin pathway","NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3","artery morphogenesis; axon guidance; cell differentiation; forebrain development; glomerular capillary formation; negative regulation of cell differentiation; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; neuroblast differentiation; neuron differentiation; neuron fate commitment; Notch signaling pathway; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of developmental process; regulation of DNA-templated transcription","cadherin binding; calcium ion binding; enzyme binding; identical protein binding; protein binding; signaling receptor activity","actin cytoskeleton; cell surface; cytosol; endoplasmic reticulum membrane; extracellular region; Golgi membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex","Development","notch receptor 3","http://www.ncbi.nlm.nih.gov/gene/?term=4854","4854","18131",null,null,null,null,"Q9UM47","Q61982","A0A8I6AWG8","A0A8P0SK77",null,"A0A1D5R5Q4","GO:0015629; GO:0009986; GO:0005829; GO:0005789; GO:0005576; GO:0000139; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0043235","GO:0045296; GO:0005509; GO:0019899; GO:0042802; GO:0005515; GO:0038023","GO:0048844; GO:0007411; GO:0030154; GO:0030900; GO:0072104; GO:0045596; GO:0045665; GO:0000122; GO:0014016; GO:0030182; GO:0048663; GO:0007219; GO:0048661; GO:0045944; GO:0050793; GO:0006355","PTHR45836:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7883|UniProtKB=Q9UM47","P00045; P00004"]
["Noxa",null,"PMAIP1","11","ms",null,7,4,"n/a","n/a","n/a","n/a","# 0918",".APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .DDR., .HIF., .IMUR., .OP., .OXS., .P53S., .SREME., .VIR.","p53 pathway","PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1","activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; cellular response to DNA damage stimulus; cellular response to glucose starvation; cellular response to hypoxia; defense response to virus; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of mitochondrial membrane potential; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of glucose metabolic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria; proteasomal protein catabolic process; reactive oxygen species metabolic process; regulation of mitochondrial membrane permeability; release of cytochrome c from mitochondria; response to dsRNA; T cell homeostasis","protein binding","Bcl-2 family protein complex; cytosol; mitochondrial outer membrane; mitochondrion; nucleus",null,"phorbol-12-myristate-13-acetate-induced protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=5366","5366","58801",null,null,null,null,"Q13794","Q9JM54","A0A8L2UK23",null,"F1SMU1",null,"GO:0097136; GO:0005829; GO:0005741; GO:0005739; GO:0005634","GO:0005515","GO:0006919; GO:0006915; GO:0006974; GO:0042149; GO:0071456; GO:0051607; GO:0097193; GO:0072332; GO:0010917; GO:0043065; GO:0043280; GO:0043517; GO:1902237; GO:1902043; GO:0010907; GO:2001244; GO:0090200; GO:0010498; GO:0072593; GO:0046902; GO:0001836; GO:0043331; GO:0043029","PTHR14299:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9108|UniProtKB=Q13794","P00059"]
["NPHS2 /Podocin",null,"NPHS2","42","rb",null,4,2,"n/a","n/a","n/a","n/a","# 2258",null,null,"PODOCIN","actin cytoskeleton reorganization; glomerular filtration; metanephric podocyte development","protein binding","cell-cell junction; cytoplasmic side of plasma membrane; endoplasmic reticulum; extracellular exosome; membrane; membrane raft; plasma membrane; protein-containing complex; slit diaphragm",null,"NPHS2 stomatin family member, podocin","http://www.ncbi.nlm.nih.gov/gene/?term=7827","7827","170484","170672",null,null,null,"Q9NP85","Q91X05","Q8K4G9","A0A8I3MWE2","A0A5G2QCG8","F7GXC0","GO:0005911; GO:0009898; GO:0005783; GO:0070062; GO:0016020; GO:0045121; GO:0005886; GO:0032991; GO:0036057","GO:0005515","GO:0031532; GO:0003094; GO:0072249","PTHR10264:SF127","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13394|UniProtKB=Q9NP85"]
["NPM (Nucleophosmin)",null,"NPM1","38","rb",null,2,2,2,1,1,2,"# 0423",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .IMUF., .NFKB., .OP., .OPA., .OT., .ST., .TRASR.",null,"NUCLEOPHOSMIN","cellular response to UV; cellular senescence; centrosome cycle; chromatin remodeling; DNA repair; intracellular protein transport; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of centrosome duplication; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleocytoplasmic transport; nucleosome assembly; positive regulation of cell cycle G2/M phase transition; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of translation; protein localization; regulation of centriole replication; regulation of centrosome duplication; regulation of eIF2 alpha phosphorylation by dsRNA; regulation of endodeoxyribonuclease activity; regulation of endoribonuclease activity; regulation of mRNA stability involved in cellular response to UV; ribosomal large subunit biogenesis; ribosomal large subunit export from nucleus; ribosomal small subunit biogenesis; ribosomal small subunit export from nucleus; ribosome assembly; rRNA export from nucleus; signal transduction","chromatin binding; core promoter sequence-specific DNA binding; DNA-binding transcription factor binding; histone binding; molecular condensate scaffold activity; NF-kappaB binding; nucleic acid binding; protein binding; protein homodimerization activity; protein kinase binding; protein kinase inhibitor activity; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; rRNA binding; Tat protein binding; transcription coactivator activity; unfolded protein binding","centrosome; cytoplasm; cytoskeleton; cytosol; focal adhesion; granular component; membrane; microtubule organizing center; nucleolus; nucleoplasm; nucleus; protein-containing complex; protein-DNA complex; ribonucleoprotein complex; spindle pole centrosome","Cell cycle control","nucleophosmin 1","http://www.ncbi.nlm.nih.gov/gene/?term=4869","4869",null,null,null,null,"706883","P06748",null,null,"A0A8P0N9R8","A0A5G2QKS9","F7AWI0","GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0001652; GO:0016020; GO:0005815; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0032993; GO:1990904; GO:0031616","GO:0003682; GO:0001046; GO:0140297; GO:0042393; GO:0140693; GO:0051059; GO:0003676; GO:0005515; GO:0042803; GO:0019901; GO:0004860; GO:0043023; GO:0043024; GO:0003723; GO:0019843; GO:0030957; GO:0003713; GO:0051082","GO:0034644; GO:0090398; GO:0007098; GO:0006338; GO:0006281; GO:0006886; GO:0043066; GO:0008285; GO:0010826; GO:0044387; GO:0006913; GO:0006334; GO:1902751; GO:0008284; GO:0045893; GO:0051092; GO:0045944; GO:0045727; GO:0008104; GO:0046599; GO:0010824; GO:0060735; GO:0032071; GO:0060699; GO:1902629; GO:0042273; GO:0000055; GO:0042274; GO:0000056; GO:0042255; GO:0006407; GO:0007165","PTHR22747:SF28","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7910|UniProtKB=P06748"]
["NR5A2",null,"NR5A2","65","rb",null,1,1,1,1,1,1,"# 1110",".CCP., .CP., .CSP., .IMUR., .OP., .OPA., .OT., .ST., .TRASR., .VIR.",null,"NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2","acinar cell differentiation; bile acid metabolic process; calcineurin-mediated signaling; cellular response to leukemia inhibitory factor; cholesterol homeostasis; embryo development ending in birth or egg hatching; homeostatic process; hormone-mediated signaling pathway; intracellular receptor signaling pathway; pancreas morphogenesis; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; positive regulation of viral genome replication; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; tissue development","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; lipid binding; metal ion binding; nuclear receptor activity; phospholipid binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coregulator binding; zinc ion binding","chromatin; cytoplasm; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Transcription regulation","nuclear receptor subfamily 5 group A member 2","http://www.ncbi.nlm.nih.gov/gene/?term=2494","2494","26424","60349",null,null,"709735","O00482","P45448","Q9QWM1","A0A8P0NDE2","A0A286ZK01","A0A5F7ZZX7","GO:0000785; GO:0005737; GO:0005654; GO:0005634; GO:0090575","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0003690; GO:0008289; GO:0046872; GO:0004879; GO:0005543; GO:0005515; GO:0000978; GO:0043565; GO:1990837; GO:0000976; GO:0001221; GO:0008270","GO:0090425; GO:0008206; GO:0097720; GO:1990830; GO:0042632; GO:0009792; GO:0042592; GO:0009755; GO:0030522; GO:0061113; GO:0045893; GO:0045944; GO:0045070; GO:0042127; GO:0006355; GO:0006357; GO:0009888","PTHR24086:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7984|UniProtKB=O00482"]
["Nrf2",null,"NFE2L2","100","rb",null,6,7,7,7,7,7,"# 0438",".ANG., .CANCER., .CANPTHW., .CD., .CSP., .DRR., .HIF., .IIR., .IMFR., .IMU., .IMUR., .OP., .OPA., .OT., .OXS., .PLAT., .SREME., .ST., .TNF., .TRASR., .UBI.",null,"NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2","aflatoxin catabolic process; aging; cell redox homeostasis; cellular response to angiotensin; cellular response to copper ion; cellular response to fluid shear stress; cellular response to glucose starvation; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to laminar fluid shear stress; cellular response to oxidative stress; cellular response to tumor necrosis factor; cellular response to xenobiotic stimulus; endoplasmic reticulum unfolded protein response; inflammatory response; integrated stress response signaling; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell death; negative regulation of endothelial cell apoptotic process; negative regulation of hematopoietic stem cell differentiation; negative regulation of hydrogen peroxide-induced cell death; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of vascular associated smooth muscle cell migration; PERK-mediated unfolded protein response; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of blood vessel endothelial cell migration; positive regulation of DNA-templated transcription; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glutathione biosynthetic process; positive regulation of neuron projection development; positive regulation of reactive oxygen species metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of cellular response to oxidative stress; regulation of DNA-templated transcription; regulation of embryonic development; regulation of innate immune response; regulation of removal of superoxide radicals; regulation of transcription by RNA polymerase II; response to endoplasmic reticulum stress; response to lithium ion; response to organic substance; response to xenobiotic stimulus","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coregulator binding","centrosome; chromatin; cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; plasma membrane; protein-DNA complex; RNA polymerase II transcription regulator complex","Immunology / inflammation","NFE2 like bZIP transcription factor 2","http://www.ncbi.nlm.nih.gov/gene/?term=4780","4780","18024","83619",null,null,null,"Q16236","Q60795","O54968","A0A8I3PIP8","A0A287B0Y3","A0A1D5QHG6","GO:0005813; GO:0000785; GO:0005737; GO:0005829; GO:0005794; GO:0005654; GO:0005634; GO:0005886; GO:0032993; GO:0090575","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0019904; GO:0000978; GO:0061629; GO:0043565; GO:0000976; GO:0001221","GO:0046223; GO:0007568; GO:0045454; GO:1904385; GO:0071280; GO:0071498; GO:0042149; GO:0070301; GO:0071456; GO:0071499; GO:0034599; GO:0071356; GO:0071466; GO:0030968; GO:0006954; GO:0140467; GO:0010667; GO:0060548; GO:2000352; GO:1902037; GO:1903206; GO:1902176; GO:1904753; GO:0036499; GO:0045766; GO:0030194; GO:0043536; GO:0045893; GO:1903071; GO:0010628; GO:0046326; GO:1903788; GO:0010976; GO:2000379; GO:0045944; GO:0061419; GO:0036003; GO:0010499; GO:0043161; GO:0016567; GO:1900407; GO:0006355; GO:0045995; GO:0045088; GO:2000121; GO:0006357; GO:0034976; GO:0010226; GO:0010033; GO:0009410","PTHR24411:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7782|UniProtKB=Q16236"]
["Nrf2",null,"NFE2L2","80","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0745",".ANG., .CANCER., .CANPTHW., .CD., .CSP., .DRR., .HIF., .IIR., .IMFR., .IMU., .IMUR., .OP., .OPA., .OT., .OXS., .PLAT., .SREME., .ST., .TNF., .TRASR., .UBI.",null,"NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2","aflatoxin catabolic process; aging; cell redox homeostasis; cellular response to angiotensin; cellular response to copper ion; cellular response to fluid shear stress; cellular response to glucose starvation; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to laminar fluid shear stress; cellular response to oxidative stress; cellular response to tumor necrosis factor; cellular response to xenobiotic stimulus; endoplasmic reticulum unfolded protein response; inflammatory response; integrated stress response signaling; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell death; negative regulation of endothelial cell apoptotic process; negative regulation of hematopoietic stem cell differentiation; negative regulation of hydrogen peroxide-induced cell death; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of vascular associated smooth muscle cell migration; PERK-mediated unfolded protein response; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of blood vessel endothelial cell migration; positive regulation of DNA-templated transcription; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glutathione biosynthetic process; positive regulation of neuron projection development; positive regulation of reactive oxygen species metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of cellular response to oxidative stress; regulation of DNA-templated transcription; regulation of embryonic development; regulation of innate immune response; regulation of removal of superoxide radicals; regulation of transcription by RNA polymerase II; response to endoplasmic reticulum stress; response to lithium ion; response to organic substance; response to xenobiotic stimulus","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coregulator binding","centrosome; chromatin; cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; plasma membrane; protein-DNA complex; RNA polymerase II transcription regulator complex","Immunology / inflammation","NFE2 like bZIP transcription factor 2","http://www.ncbi.nlm.nih.gov/gene/?term=4780","4780","18024","83619",null,null,null,"Q16236","Q60795","O54968","A0A8I3PIP8","A0A287B0Y3","A0A1D5QHG6","GO:0005813; GO:0000785; GO:0005737; GO:0005829; GO:0005794; GO:0005654; GO:0005634; GO:0005886; GO:0032993; GO:0090575","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0019904; GO:0000978; GO:0061629; GO:0043565; GO:0000976; GO:0001221","GO:0046223; GO:0007568; GO:0045454; GO:1904385; GO:0071280; GO:0071498; GO:0042149; GO:0070301; GO:0071456; GO:0071499; GO:0034599; GO:0071356; GO:0071466; GO:0030968; GO:0006954; GO:0140467; GO:0010667; GO:0060548; GO:2000352; GO:1902037; GO:1903206; GO:1902176; GO:1904753; GO:0036499; GO:0045766; GO:0030194; GO:0043536; GO:0045893; GO:1903071; GO:0010628; GO:0046326; GO:1903788; GO:0010976; GO:2000379; GO:0045944; GO:0061419; GO:0036003; GO:0010499; GO:0043161; GO:0016567; GO:1900407; GO:0006355; GO:0045995; GO:0045088; GO:2000121; GO:0006357; GO:0034976; GO:0010226; GO:0010033; GO:0009410","PTHR24411:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7782|UniProtKB=Q16236"]
["Nucleolin",null,"NCL","100","ms",null,2,4,8,1,8,8,"# 0341",".ANG., .CANCER., .CSP., .EGFR., .INS., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TRASR.",null,"NUCLEOLIN","angiogenesis; cellular response to epidermal growth factor stimulus; cellular response to leukemia inhibitory factor; negative regulation of insulin receptor signaling pathway; negative regulation of translation; positive regulation of mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; regulation of peptidyl-tyrosine phosphorylation","DNA binding; DNA topoisomerase binding; DNA-binding transcription factor binding; identical protein binding; insulin receptor substrate binding; mRNA 5'-UTR binding; nucleic acid binding; PH domain binding; protein binding; protein C-terminus binding; RNA binding; telomeric DNA binding","cell cortex; chromosome; cornified envelope; cytoplasm; cytoplasmic ribonucleoprotein granule; extracellular exosome; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex","Chromatin regulation / epigenetics","nucleolin","http://www.ncbi.nlm.nih.gov/gene/?term=4691","4691","17975",null,null,null,"720965","P19338","P09405","A0A8I5Y747","A0A8P0P6F8","A0A5G2QXD8","H9H3Z4","GO:0005938; GO:0005694; GO:0001533; GO:0005737; GO:0036464; GO:0070062; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:1990904; GO:0005681","GO:0003677; GO:0044547; GO:0140297; GO:0042802; GO:0043560; GO:0048027; GO:0003676; GO:0042731; GO:0005515; GO:0008022; GO:0003723; GO:0042162","GO:0001525; GO:0071364; GO:1990830; GO:0046627; GO:0017148; GO:0048026; GO:0045944; GO:1901838; GO:0050730","PTHR48034:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7667|UniProtKB=P19338"]
["Nucleolin - phospho","Thr76/Thr84","NCL","100","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0483",".ANG., .CANCER., .CSP., .EGFR., .INS., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TRASR.",null,"NUCLEOLIN","angiogenesis; cellular response to epidermal growth factor stimulus; cellular response to leukemia inhibitory factor; negative regulation of insulin receptor signaling pathway; negative regulation of translation; positive regulation of mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; regulation of peptidyl-tyrosine phosphorylation","DNA binding; DNA topoisomerase binding; DNA-binding transcription factor binding; identical protein binding; insulin receptor substrate binding; mRNA 5'-UTR binding; nucleic acid binding; PH domain binding; protein binding; protein C-terminus binding; RNA binding; telomeric DNA binding","cell cortex; chromosome; cornified envelope; cytoplasm; cytoplasmic ribonucleoprotein granule; extracellular exosome; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex","Chromatin regulation / epigenetics","nucleolin","http://www.ncbi.nlm.nih.gov/gene/?term=4691","4691","17975",null,null,null,"720965","P19338","P09405","A0A8I5Y747","A0A8P0P6F8","A0A5G2QXD8","H9H3Z4","GO:0005938; GO:0005694; GO:0001533; GO:0005737; GO:0036464; GO:0070062; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:1990904; GO:0005681","GO:0003677; GO:0044547; GO:0140297; GO:0042802; GO:0043560; GO:0048027; GO:0003676; GO:0042731; GO:0005515; GO:0008022; GO:0003723; GO:0042162","GO:0001525; GO:0071364; GO:1990830; GO:0046627; GO:0017148; GO:0048026; GO:0045944; GO:1901838; GO:0050730","PTHR48034:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7667|UniProtKB=P19338"]
["Numb",null,"NUMB","74, 72","rb",null,2,1,1,8,8,8,"# 1410",".CCP., .CP., .CSP., .DEV., .MIG., .NOTCH., .OP., .OT.","Notch signaling pathway","PROTEIN NUMB HOMOLOG","adherens junction organization; axonogenesis; forebrain development; lateral ventricle development; negative regulation of protein localization to plasma membrane; nervous system development; neuroblast division in subventricular zone; neuroblast proliferation; positive regulation of cell migration; positive regulation of neurogenesis; regulation of postsynaptic neurotransmitter receptor internalization","alpha-catenin binding; beta-catenin binding; cadherin binding; protein binding","apical part of cell; basolateral plasma membrane; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; early endosome; endosome; endosome membrane; focal adhesion; glutamatergic synapse; membrane; plasma membrane","Development","NUMB endocytic adaptor protein","http://www.ncbi.nlm.nih.gov/gene/?term=8650","8650","18222",null,null,null,null,"P49757","Q9QZS3","H9KVE4","A0A8I3NMW5","A0A287A1C6","A0A1D5Q621","GO:0045177; GO:0016323; GO:0005905; GO:0030136; GO:0005737; GO:0031410; GO:0005769; GO:0005768; GO:0010008; GO:0005925; GO:0098978; GO:0016020; GO:0005886","GO:0045294; GO:0008013; GO:0045296; GO:0005515","GO:0034332; GO:0007409; GO:0030900; GO:0021670; GO:1903077; GO:0007399; GO:0021849; GO:0007405; GO:0030335; GO:0050769; GO:0099149","PTHR47368:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8060|UniProtKB=P49757","P00045"]
["NUP62",null,"NUP62","53","rb",null,2,1,"n/a","n/a","n/a","n/a","# 1656",".APO., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .ErbB., .IMUF., .MAPK., .NFKB., .OP., .OPA., .OT., .RAS., .RTK., .ST., .TRASR.",null,"NUCLEAR PORE GLYCOPROTEIN P62","cell death; cell surface receptor signaling pathway; cellular senescence; centriole assembly; centrosome cycle; mitotic centrosome separation; mitotic metaphase plate congression; mRNA transport; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of programmed cell death; negative regulation of Ras protein signal transduction; nucleocytoplasmic transport; positive regulation of centriole replication; positive regulation of DNA-templated transcription; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of mitotic cytokinetic process; positive regulation of mitotic nuclear division; positive regulation of protein localization to centrosome; protein import into nucleus; protein transport; regulation of mitotic spindle organization; regulation of Ras protein signal transduction; regulation of signal transduction; RNA export from nucleus","chromatin binding; Hsp70 protein binding; Hsp90 protein binding; phospholipid binding; protein binding; PTB domain binding; SH2 domain binding; signaling receptor complex adaptor activity; structural constituent of nuclear pore; ubiquitin binding","centrosome; cytoplasm; cytoskeleton; Flemming body; microtubule organizing center; mitotic spindle; nuclear envelope; nuclear membrane; nuclear pore; nuclear pore central transport channel; nucleoplasm; nucleus; ribonucleoprotein complex; spindle pole",null,"nucleoporin 62","http://www.ncbi.nlm.nih.gov/gene/?term=23636","23636","18226","65274",null,null,"100426308","P37198","Q63850","P17955",null,null,"F6ZN69","GO:0005813; GO:0005737; GO:0005856; GO:0090543; GO:0005815; GO:0072686; GO:0005635; GO:0031965; GO:0005643; GO:0044613; GO:0005654; GO:0005634; GO:1990904; GO:0000922","GO:0003682; GO:0030544; GO:0051879; GO:0005543; GO:0005515; GO:0051425; GO:0042169; GO:0030159; GO:0017056; GO:0043130","GO:0008219; GO:0007166; GO:0090398; GO:0098534; GO:0007098; GO:0007100; GO:0007080; GO:0051028; GO:0043066; GO:0008285; GO:0042059; GO:0043407; GO:0043069; GO:0046580; GO:0006913; GO:0046601; GO:0045893; GO:0045742; GO:0043123; GO:1903438; GO:0045840; GO:1904781; GO:0006606; GO:0015031; GO:0060236; GO:0046578; GO:0009966; GO:0006405","PTHR12084:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8066|UniProtKB=P37198"]
["OAS2",null,"OAS2","79","rb",null,6,6,6,2,2,6,"# 0723",".CSP., .IIR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .OP., .VIR.",null,"2'-5'-OLIGOADENYLATE SYNTHASE 2","defense response to bacterium; defense response to virus; immune system process; innate immune response; interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; nucleobase-containing compound metabolic process; positive regulation of interferon-beta production; positive regulation of tumor necrosis factor production; regulation of lactation; regulation of ribonuclease activity; response to bacterium; response to virus; RNA catabolic process; type I interferon-mediated signaling pathway","2'-5'-oligoadenylate synthetase activity; ATP binding; double-stranded RNA binding; metal ion binding; nucleotide binding; nucleotidyltransferase activity; protein binding; RNA binding; transferase activity","cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; nucleoplasm; perinuclear region of cytoplasm","Immunology","2'-5'-oligoadenylate synthetase 2","http://www.ncbi.nlm.nih.gov/gene/?term=4939","4939","246728",null,null,null,null,"P29728","E9Q9A9","M0RBB5","A0A8P0P2L7","A0A286ZK05","F6TGI7","GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005654; GO:0048471","GO:0001730; GO:0005524; GO:0003725; GO:0046872; GO:0000166; GO:0016779; GO:0005515; GO:0003723; GO:0016740","GO:0042742; GO:0051607; GO:0002376; GO:0045087; GO:0070106; GO:0045071; GO:0006139; GO:0032728; GO:0032760; GO:1903487; GO:0060700; GO:0009617; GO:0009615; GO:0006401; GO:0060337","PTHR11258:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8087|UniProtKB=P29728"]
["OB-Cadherin",null,"CDH11","120","rb",null,2,7,7,7,5,6,"# 1517",".CADH., .CSP., .DEV., .MIG., .OP., .OPA., .OT., .WNT.","Cadherin signaling pathway; Wnt signaling pathway","CADHERIN-11","adherens junction organization; aortic valve formation; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell migration; cell morphogenesis; cell-cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; cell-cell junction assembly; corticospinal tract morphogenesis; focal adhesion assembly; homophilic cell adhesion via plasma membrane adhesion molecules; modulation of chemical synaptic transmission; negative regulation of cell migration; ossification; skeletal system development","cadherin binding; calcium ion binding; metal ion binding","adherens junction; catenin complex; cytoplasm; extracellular exosome; glutamatergic synapse; membrane; plasma membrane; Schaffer collateral - CA1 synapse; synapse","Adhesion","cadherin 11","http://www.ncbi.nlm.nih.gov/gene/?term=1009","1009","12552","84407",null,"100525579","708826","P55287","P55288","F1MAH6","A0A8P0NLW5","F1RFU7","F7GFF0","GO:0005912; GO:0016342; GO:0005737; GO:0070062; GO:0098978; GO:0016020; GO:0005886; GO:0098685; GO:0045202","GO:0045296; GO:0005509; GO:0046872","GO:0034332; GO:0003189; GO:0016339; GO:0007155; GO:0016477; GO:0000902; GO:0098609; GO:0098742; GO:0007043; GO:0021957; GO:0048041; GO:0007156; GO:0050804; GO:0030336; GO:0001503; GO:0001501","PTHR24027:SF85","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1750|UniProtKB=P55287","P00012; P00057"]
["Ornithine aminotransferase (OAT)",null,"OAT","49","rb",null,1,4,"n/a","n/a","n/a","n/a","# 1793",null,null,"ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL","arginine catabolic process to glutamate; arginine catabolic process to proline via ornithine; L-proline biosynthetic process; visual perception","catalytic activity; identical protein binding; ornithine(lysine) transaminase activity; ornithine-oxo-acid transaminase activity; protein binding; pyridoxal phosphate binding; transaminase activity; transferase activity","cytoplasm; mitochondrial matrix; mitochondrion; nucleoplasm",null,"ornithine aminotransferase","http://www.ncbi.nlm.nih.gov/gene/?term=4942","4942","18242","64313","477858",null,"693970","P04181","P29758","P04182","A0A8P0NN46","A0A287BBB4","A0A5F7ZD93","GO:0005737; GO:0005759; GO:0005739; GO:0005654","GO:0003824; GO:0042802; GO:0050155; GO:0004587; GO:0005515; GO:0030170; GO:0008483; GO:0016740","GO:0019544; GO:0010121; GO:0055129; GO:0007601","PTHR11986:SF118","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8091|UniProtKB=P04181"]
["Osteopontin (OPN, SPP1)",null,"SPP1","36","rb",null,2,6,"n/a","n/a","n/a","n/a","# 2111",".CCP., .CP., .CSP., .IMFR., .IMUF., .IMUR., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TOLL., .TRASR.",null,"OSTEOPONTIN","androgen catabolic process; biomineral tissue development; cell adhesion; cell differentiation; cellular response to testosterone stimulus; decidualization; embryo implantation; inflammatory response; negative regulation of collateral sprouting of intact axon in response to injury; ossification; osteoblast differentiation; positive regulation of bone resorption; positive regulation of DNA-templated transcription; positive regulation of estradiol secretion; response to macrophage colony-stimulating factor; response to organic substance; response to steroid hormone; response to vitamin D; signal transduction","cytokine activity; extracellular matrix binding; integrin binding; ion binding; protein binding; small molecule binding","cell projection; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; Golgi apparatus; perinuclear region of cytoplasm; vesicle",null,"secreted phosphoprotein 1","http://www.ncbi.nlm.nih.gov/gene/?term=6696","6696","20750","25353","478471","397087","704930","P10451","P10923","P08721","A0A8P0NMW9","P14287","F7F5M6","GO:0042995; GO:0005788; GO:0070062; GO:0005576; GO:0005615; GO:0005794; GO:0048471; GO:0031982","GO:0005125; GO:0050840; GO:0005178; GO:0043167; GO:0005515; GO:0036094","GO:0006710; GO:0031214; GO:0007155; GO:0030154; GO:0071394; GO:0046697; GO:0007566; GO:0006954; GO:0048685; GO:0001503; GO:0001649; GO:0045780; GO:0045893; GO:2000866; GO:0036005; GO:0010033; GO:0048545; GO:0033280; GO:0007165","PTHR10607:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11255|UniProtKB=P10451"]
["OSTF1",null,"OSTF1","24","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2989",".CSP., .OPA., .ST.",null,"OSTEOCLAST-STIMULATING FACTOR 1","ossification; signal transduction","protein binding; SH3 domain binding","cytoplasm; extracellular region; ficolin-1-rich granule lumen; secretory granule lumen",null,"osteoclast stimulating factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=26578","26578","20409",null,null,"397066","703986","Q92882","Q62422","A0A8I6A1U4","A0A8P0NRP4","Q8MJ49","F7D3T7","GO:0005737; GO:0005576; GO:1904813; GO:0034774","GO:0005515; GO:0017124","GO:0001503; GO:0007165","PTHR24155:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8510|UniProtKB=Q92882"]
["OTC (Ornithine transcarbamylase)",null,"OTC","40","rb",null,6,2,"n/a","n/a","n/a","n/a","# 1136",".DRR., .OP., .OT.","Arginine biosynthesis","ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL","amino acid biosynthetic process; amino acid metabolic process; ammonium homeostasis; anion homeostasis; arginine biosynthetic process; arginine biosynthetic process via ornithine; citrulline biosynthetic process; liver development; midgut development; organonitrogen compound biosynthetic process; ornithine catabolic process; ornithine metabolic process; response to biotin; response to insulin; response to nutrient levels; response to xenobiotic stimulus; response to zinc ion; urea cycle","amino acid binding; carboxyl- or carbamoyltransferase activity; identical protein binding; ornithine carbamoyltransferase activity; phosphate ion binding; phospholipid binding; transferase activity","cytoplasm; intracellular membrane-bounded organelle; mitochondrial inner membrane; mitochondrial matrix; mitochondrion","Metabolism","ornithine transcarbamylase","http://www.ncbi.nlm.nih.gov/gene/?term=5009","5009","18416","25611",null,"397438",null,"P00480","P11725","P00481","A0A8I3PR49","A0A480E1W6","A0A5F8AHB5","GO:0005737; GO:0043231; GO:0005743; GO:0005759; GO:0005739","GO:0016597; GO:0016743; GO:0042802; GO:0004585; GO:0042301; GO:0005543; GO:0016740","GO:0008652; GO:0006520; GO:0097272; GO:0055081; GO:0006526; GO:0042450; GO:0019240; GO:0001889; GO:0007494; GO:1901566; GO:0006593; GO:0006591; GO:0070781; GO:0032868; GO:0031667; GO:0009410; GO:0010043; GO:0000050","PTHR45753:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8512|UniProtKB=P00480","P02728"]
["OVOS2",null,"OVOS2","161","rb",null,2,8,"n/a","n/a","n/a","n/a","# 2861",null,null,"OVOSTATIN HOMOLOG 1-RELATED","negative regulation of peptidase activity","endopeptidase inhibitor activity; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity","extracellular region; extracellular space",null,null,"http://www.ncbi.nlm.nih.gov/gene/?term=144203","144203",null,null,null,null,null,"Q6IE36",null,null,null,null,null,"GO:0005576; GO:0005615","GO:0004866; GO:0030414; GO:0004867","GO:0010466","PTHR11412:SF174","http://pantherdb.org/genes/gene.do?acc=HUMAN|Gene=OVOS2|UniProtKB=Q6IE36"]
["p15 (PAF)",null,"PCLAF","12","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1622",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .OP.",null,"PCNA-ASSOCIATED FACTOR","cellular response to DNA damage stimulus; centrosome cycle; DNA repair; DNA replication; regulation of cell cycle; response to UV; translesion synthesis","chromatin binding; molecular adaptor activity; protein binding","centrosome; cytoplasm; nucleoplasm; nucleus; perinuclear region of cytoplasm","DNA replication regulation","PCNA clamp associated factor","http://www.ncbi.nlm.nih.gov/gene/?term=9768","9768","68026",null,"106557458",null,"100423080","Q15004","Q9CQX4",null,"A0A8I3PD98","A0A5G2QIY0","F7G277","GO:0005813; GO:0005737; GO:0005654; GO:0005634; GO:0048471","GO:0003682; GO:0060090; GO:0005515","GO:0006974; GO:0007098; GO:0006281; GO:0006260; GO:0051726; GO:0009411; GO:0019985","PTHR15679:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=28961|UniProtKB=Q15004"]
["p15-INK4b (CDKN2B)",null,"CDKN2B","15","ms",null,4,4,"n/a","n/a","n/a","n/a","# 2142",".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .FOXO., .OP., .OPA., .P53S., .SCLC., .ST., .TGFB.","p53 pathway","CYCLIN-DEPENDENT KINASE 4 INHIBITOR B","aging; cell cycle; cellular response to extracellular stimulus; cellular response to nutrient; cellular response to transforming growth factor beta stimulus; cellular senescence; liver development; megakaryocyte differentiation; negative regulation of cell cycle G1/S phase transition; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of glial cell proliferation; negative regulation of phosphorylation; positive regulation of epithelial cell differentiation; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; response to cytokine; response to organic cyclic compound; spleen development","cyclin-dependent protein serine/threonine kinase inhibitor activity; protein binding; protein kinase binding","cytoplasm; cytosol; nucleus","Cell cycle control","cyclin dependent kinase inhibitor 2B","http://www.ncbi.nlm.nih.gov/gene/?term=1030","1030","12579","25164",null,null,null,"P42772","P55271","P55272","A0A8P0PFD8",null,null,"GO:0005737; GO:0005829; GO:0005634","GO:0004861; GO:0005515; GO:0019901","GO:0007568; GO:0007049; GO:0031668; GO:0031670; GO:0071560; GO:0090398; GO:0001889; GO:0030219; GO:1902807; GO:0008285; GO:0045736; GO:0050680; GO:2000134; GO:0060253; GO:0042326; GO:0030858; GO:0030511; GO:0000079; GO:0070316; GO:2000045; GO:0034097; GO:0014070; GO:0048536","PTHR24201:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1788|UniProtKB=P42772","P00059"]
["p16-INK4 (CDKN2A)",null,"CDKN2A","17","rb",null,2,7,7,7,7,7,"# 0338",".BLC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .GLI., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .RAS., .RTK., .ST., .TRASR.","p53 pathway","CYCLIN-DEPENDENT KINASE INHIBITOR 2A","cell cycle; cellular senescence; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cell-matrix adhesion; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-templated transcription; negative regulation of NF-kappaB transcription factor activity; negative regulation of phosphorylation; positive regulation of macrophage apoptotic process; positive regulation of smooth muscle cell apoptotic process; Ras protein signal transduction; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of G1/S transition of mitotic cell cycle; replicative senescence","cyclin-dependent protein serine/threonine kinase inhibitor activity; NF-kappaB binding; protein binding; protein kinase binding; RNA binding","cytoplasm; cytosol; nucleus; senescence-associated heterochromatin focus","Cell cycle control","cyclin dependent kinase inhibitor 2A","http://www.ncbi.nlm.nih.gov/gene/?term=1029","1029",null,null,null,null,null,"P42771",null,null,null,null,null,"GO:0005737; GO:0005829; GO:0005634; GO:0035985","GO:0004861; GO:0051059; GO:0005515; GO:0019901; GO:0003723","GO:0007049; GO:0090398; GO:0030308; GO:0008285; GO:0001953; GO:0045736; GO:0045892; GO:0032088; GO:0042326; GO:2000111; GO:0034393; GO:0007265; GO:0051726; GO:0000079; GO:2000045; GO:0090399","PTHR24201:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1787|UniProtKB=P42771","P00059"]
["p21 (CDKN1A)",null,"CDKN1A","21","rb",null,1,4,8,8,8,8,"# 2334",".APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .EGFR., .EMC., .FOXO., .GLI., .HEPB., .HIF., .IMUF., .INT., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR.","p53 pathway; Interleukin signaling pathway; p53 pathway feedback loops 2","CYCLIN-DEPENDENT KINASE INHIBITOR 1","cell cycle; cellular response to amino acid starvation; cellular response to DNA damage stimulus; cellular response to extracellular stimulus; cellular response to gamma radiation; cellular response to ionizing radiation; cellular response to UV-B; cellular senescence; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; G1/S transition of mitotic cell cycle; heart development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mitotic G2 DNA damage checkpoint signaling; negative regulation of cardiac muscle tissue regeneration; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA biosynthetic process; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of phosphorylation; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of B cell proliferation; positive regulation of fibroblast proliferation; positive regulation of programmed cell death; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; protein import into nucleus; Ras protein signal transduction; regulation of cell cycle; regulation of cell cycle G1/S phase transition; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA biosynthetic process; regulation of G1/S transition of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; regulation of macromolecule metabolic process; regulation of mitotic cell cycle; replicative senescence; response to UV; signal transduction by p53 class mediator; stress-induced premature senescence; tissue regeneration; wound healing","cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; metal ion binding; molecular function activator activity; molecular function inhibitor activity; protein binding; protein kinase binding; protein kinase inhibitor activity; protein sequestering activity; protein-containing complex binding; ubiquitin protein ligase binding","cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; nuclear body; nucleolus; nucleoplasm; nucleus; PCNA-p21 complex; protein-containing complex","Cell cycle control","cyclin dependent kinase inhibitor 1A","http://www.ncbi.nlm.nih.gov/gene/?term=1026","1026","12575",null,null,null,null,"P38936","P39689","A0A8I5ZZ18","A0A8P0SSL8","F1RVT3",null,"GO:0000307; GO:0005737; GO:0005829; GO:0016604; GO:0005730; GO:0005654; GO:0005634; GO:0070557; GO:0032991","GO:0030332; GO:0019912; GO:0004861; GO:0046872; GO:0140677; GO:0140678; GO:0005515; GO:0019901; GO:0004860; GO:0140311; GO:0044877; GO:0031625","GO:0007049; GO:0034198; GO:0006974; GO:0031668; GO:0071480; GO:0071479; GO:0071493; GO:0090398; GO:0006977; GO:0006978; GO:0000082; GO:0007507; GO:0097193; GO:0042771; GO:0007095; GO:1905179; GO:0030308; GO:0008285; GO:1904030; GO:0045736; GO:2000279; GO:2000134; GO:0010629; GO:0042326; GO:0032091; GO:0001933; GO:1904706; GO:0030890; GO:0048146; GO:0043068; GO:0045860; GO:0001934; GO:2000379; GO:0006606; GO:0007265; GO:0051726; GO:1902806; GO:0000079; GO:2000278; GO:2000045; GO:0010389; GO:0060255; GO:0007346; GO:0090399; GO:0009411; GO:0072331; GO:0090400; GO:0042246; GO:0042060","PTHR46778:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1784|UniProtKB=P38936","P00059; P00036; P04398"]
["p21 (CDKN1A) - phospho","Thr145","CDKN1A","21","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2343",".APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .EGFR., .EMC., .FOXO., .GLI., .HEPB., .HIF., .IMUF., .INT., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR.","p53 pathway; Interleukin signaling pathway; p53 pathway feedback loops 2","CYCLIN-DEPENDENT KINASE INHIBITOR 1","cell cycle; cellular response to amino acid starvation; cellular response to DNA damage stimulus; cellular response to extracellular stimulus; cellular response to gamma radiation; cellular response to ionizing radiation; cellular response to UV-B; cellular senescence; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; G1/S transition of mitotic cell cycle; heart development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mitotic G2 DNA damage checkpoint signaling; negative regulation of cardiac muscle tissue regeneration; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA biosynthetic process; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of phosphorylation; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of B cell proliferation; positive regulation of fibroblast proliferation; positive regulation of programmed cell death; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; protein import into nucleus; Ras protein signal transduction; regulation of cell cycle; regulation of cell cycle G1/S phase transition; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA biosynthetic process; regulation of G1/S transition of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; regulation of macromolecule metabolic process; regulation of mitotic cell cycle; replicative senescence; response to UV; signal transduction by p53 class mediator; stress-induced premature senescence; tissue regeneration; wound healing","cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; metal ion binding; molecular function activator activity; molecular function inhibitor activity; protein binding; protein kinase binding; protein kinase inhibitor activity; protein sequestering activity; protein-containing complex binding; ubiquitin protein ligase binding","cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; nuclear body; nucleolus; nucleoplasm; nucleus; PCNA-p21 complex; protein-containing complex",null,"cyclin dependent kinase inhibitor 1A","http://www.ncbi.nlm.nih.gov/gene/?term=1026","1026","12575",null,null,null,null,"P38936","P39689","A0A8I5ZZ18","A0A8P0SSL8","F1RVT3",null,"GO:0000307; GO:0005737; GO:0005829; GO:0016604; GO:0005730; GO:0005654; GO:0005634; GO:0070557; GO:0032991","GO:0030332; GO:0019912; GO:0004861; GO:0046872; GO:0140677; GO:0140678; GO:0005515; GO:0019901; GO:0004860; GO:0140311; GO:0044877; GO:0031625","GO:0007049; GO:0034198; GO:0006974; GO:0031668; GO:0071480; GO:0071479; GO:0071493; GO:0090398; GO:0006977; GO:0006978; GO:0000082; GO:0007507; GO:0097193; GO:0042771; GO:0007095; GO:1905179; GO:0030308; GO:0008285; GO:1904030; GO:0045736; GO:2000279; GO:2000134; GO:0010629; GO:0042326; GO:0032091; GO:0001933; GO:1904706; GO:0030890; GO:0048146; GO:0043068; GO:0045860; GO:0001934; GO:2000379; GO:0006606; GO:0007265; GO:0051726; GO:1902806; GO:0000079; GO:2000278; GO:2000045; GO:0010389; GO:0060255; GO:0007346; GO:0090399; GO:0009411; GO:0072331; GO:0090400; GO:0042246; GO:0042060","PTHR46778:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1784|UniProtKB=P38936","P00059; P00036; P04398"]
["p21 (CDKN1A) - phospho","Thr145","CDKN1A","18","rb",null,4,4,"n/a","n/a","n/a","n/a","# 3080",".APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DI., .EGFR., .EMC., .FOXO., .GLI., .HEPB., .HIF., .IMUF., .INT., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR.","p53 pathway; Interleukin signaling pathway; p53 pathway feedback loops 2","CYCLIN-DEPENDENT KINASE INHIBITOR 1","cell cycle; cellular response to amino acid starvation; cellular response to DNA damage stimulus; cellular response to extracellular stimulus; cellular response to gamma radiation; cellular response to ionizing radiation; cellular response to UV-B; cellular senescence; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; G1/S transition of mitotic cell cycle; heart development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mitotic G2 DNA damage checkpoint signaling; negative regulation of cardiac muscle tissue regeneration; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA biosynthetic process; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of phosphorylation; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of B cell proliferation; positive regulation of fibroblast proliferation; positive regulation of programmed cell death; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; protein import into nucleus; Ras protein signal transduction; regulation of cell cycle; regulation of cell cycle G1/S phase transition; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA biosynthetic process; regulation of G1/S transition of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; regulation of macromolecule metabolic process; regulation of mitotic cell cycle; replicative senescence; response to UV; signal transduction by p53 class mediator; stress-induced premature senescence; tissue regeneration; wound healing","cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; metal ion binding; molecular function activator activity; molecular function inhibitor activity; protein binding; protein kinase binding; protein kinase inhibitor activity; protein sequestering activity; protein-containing complex binding; ubiquitin protein ligase binding","cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; nuclear body; nucleolus; nucleoplasm; nucleus; PCNA-p21 complex; protein-containing complex",null,"cyclin dependent kinase inhibitor 1A","http://www.ncbi.nlm.nih.gov/gene/?term=1026","1026","12575",null,null,null,null,"P38936","P39689","A0A8I5ZZ18","A0A8P0SSL8","F1RVT3",null,"GO:0000307; GO:0005737; GO:0005829; GO:0016604; GO:0005730; GO:0005654; GO:0005634; GO:0070557; GO:0032991","GO:0030332; GO:0019912; GO:0004861; GO:0046872; GO:0140677; GO:0140678; GO:0005515; GO:0019901; GO:0004860; GO:0140311; GO:0044877; GO:0031625","GO:0007049; GO:0034198; GO:0006974; GO:0031668; GO:0071480; GO:0071479; GO:0071493; GO:0090398; GO:0006977; GO:0006978; GO:0000082; GO:0007507; GO:0097193; GO:0042771; GO:0007095; GO:1905179; GO:0030308; GO:0008285; GO:1904030; GO:0045736; GO:2000279; GO:2000134; GO:0010629; GO:0042326; GO:0032091; GO:0001933; GO:1904706; GO:0030890; GO:0048146; GO:0043068; GO:0045860; GO:0001934; GO:2000379; GO:0006606; GO:0007265; GO:0051726; GO:1902806; GO:0000079; GO:2000278; GO:2000045; GO:0010389; GO:0060255; GO:0007346; GO:0090399; GO:0009411; GO:0072331; GO:0090400; GO:0042246; GO:0042060","PTHR46778:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1784|UniProtKB=P38936","P00059; P00036; P04398"]
["p27-Kip1 (CDKN1B)",null,"CDKN1B","27","ms",null,1.1000000000000001,1,1,1,1,1,"# 1932",".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DRR., .EGFR., .FOXO., .HIF., .INT., .NOTCH., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR.","Interleukin signaling pathway","CYCLIN-DEPENDENT KINASE INHIBITOR 1B","apoptotic process; autophagic cell death; cell cycle; cell death; cellular response to antibiotic; cellular response to hypoxia; cellular response to lithium ion; cellular response to organic cyclic compound; cellular senescence; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epithelial cell apoptotic process; epithelial cell proliferation involved in prostate gland development; G1/S transition of mitotic cell cycle; heart development; inner ear development; localization; negative regulation of cardiac muscle tissue regeneration; negative regulation of cell cycle G1/S phase transition; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell apoptotic process; negative regulation of epithelial cell proliferation; negative regulation of epithelial cell proliferation involved in prostate gland development; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of vascular associated smooth muscle cell proliferation; Notch signaling pathway; nuclear export; placenta development; positive regulation of cell death; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of ubiquitin protein ligase activity; potassium ion transport; regulation of cell cycle; regulation of cell cycle G1/S phase transition; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of exit from mitosis; regulation of G1/S transition of mitotic cell cycle; regulation of lens fiber cell differentiation; regulation of macromolecule metabolic process; regulation of mitotic cell cycle; response to amino acid; response to cadmium ion; response to estradiol; response to glucose; response to hypoxia; response to organic cyclic compound; response to peptide hormone; response to xenobiotic stimulus; sensory perception of sound","chaperone binding; cyclin binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; Hsp70 protein binding; molecular adaptor activity; molecular function inhibitor activity; protein binding; protein kinase binding; protein kinase inhibitor activity; protein phosphatase binding; protein-containing complex binding; ubiquitin ligase activator activity; ubiquitin protein ligase binding","Cul4A-RING E3 ubiquitin ligase complex; cytoplasm; cytosol; endosome; intracellular membrane-bounded organelle; nucleoplasm; nucleus; protein-containing complex","Cell cycle control","cyclin dependent kinase inhibitor 1B","http://www.ncbi.nlm.nih.gov/gene/?term=1027","1027","12576","83571","403429",null,null,"P46527","P46414","O08769","F1PGU6",null,null,"GO:0031464; GO:0005737; GO:0005829; GO:0005768; GO:0043231; GO:0005654; GO:0005634; GO:0032991","GO:0051087; GO:0030332; GO:0004861; GO:0030544; GO:0060090; GO:0140678; GO:0005515; GO:0019901; GO:0004860; GO:0019903; GO:0044877; GO:1990757; GO:0031625","GO:0006915; GO:0048102; GO:0007049; GO:0008219; GO:0071236; GO:0071456; GO:0071285; GO:0071407; GO:0090398; GO:0006977; GO:1904019; GO:0060767; GO:0000082; GO:0007507; GO:0048839; GO:0051179; GO:1905179; GO:1902807; GO:0030308; GO:0008285; GO:1904030; GO:0045736; GO:0045892; GO:1904036; GO:0050680; GO:0060770; GO:0033673; GO:0045930; GO:0042326; GO:1904706; GO:0007219; GO:0051168; GO:0001890; GO:0010942; GO:0008284; GO:0045737; GO:0031116; GO:0045732; GO:1904668; GO:0006813; GO:0051726; GO:1902806; GO:0000079; GO:0007096; GO:2000045; GO:1902746; GO:0060255; GO:0007346; GO:0043200; GO:0046686; GO:0032355; GO:0009749; GO:0001666; GO:0014070; GO:0043434; GO:0009410; GO:0007605","PTHR10265:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1785|UniProtKB=P46527","P00036"]
["p27-Kip1 (CDKN1B) - phospho","Ser10","CDKN1B","22","rb",null,1.1000000000000001,1,1,8,1.1000000000000001,8,"# 1969",".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DRR., .EGFR., .FOXO., .HIF., .INT., .NOTCH., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR.","Interleukin signaling pathway","CYCLIN-DEPENDENT KINASE INHIBITOR 1B","apoptotic process; autophagic cell death; cell cycle; cell death; cellular response to antibiotic; cellular response to hypoxia; cellular response to lithium ion; cellular response to organic cyclic compound; cellular senescence; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epithelial cell apoptotic process; epithelial cell proliferation involved in prostate gland development; G1/S transition of mitotic cell cycle; heart development; inner ear development; localization; negative regulation of cardiac muscle tissue regeneration; negative regulation of cell cycle G1/S phase transition; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell apoptotic process; negative regulation of epithelial cell proliferation; negative regulation of epithelial cell proliferation involved in prostate gland development; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of vascular associated smooth muscle cell proliferation; Notch signaling pathway; nuclear export; placenta development; positive regulation of cell death; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of ubiquitin protein ligase activity; potassium ion transport; regulation of cell cycle; regulation of cell cycle G1/S phase transition; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of exit from mitosis; regulation of G1/S transition of mitotic cell cycle; regulation of lens fiber cell differentiation; regulation of macromolecule metabolic process; regulation of mitotic cell cycle; response to amino acid; response to cadmium ion; response to estradiol; response to glucose; response to hypoxia; response to organic cyclic compound; response to peptide hormone; response to xenobiotic stimulus; sensory perception of sound","chaperone binding; cyclin binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; Hsp70 protein binding; molecular adaptor activity; molecular function inhibitor activity; protein binding; protein kinase binding; protein kinase inhibitor activity; protein phosphatase binding; protein-containing complex binding; ubiquitin ligase activator activity; ubiquitin protein ligase binding","Cul4A-RING E3 ubiquitin ligase complex; cytoplasm; cytosol; endosome; intracellular membrane-bounded organelle; nucleoplasm; nucleus; protein-containing complex","Cell cycle control","cyclin dependent kinase inhibitor 1B","http://www.ncbi.nlm.nih.gov/gene/?term=1027","1027","12576","83571","403429",null,null,"P46527","P46414","O08769","F1PGU6",null,null,"GO:0031464; GO:0005737; GO:0005829; GO:0005768; GO:0043231; GO:0005654; GO:0005634; GO:0032991","GO:0051087; GO:0030332; GO:0004861; GO:0030544; GO:0060090; GO:0140678; GO:0005515; GO:0019901; GO:0004860; GO:0019903; GO:0044877; GO:1990757; GO:0031625","GO:0006915; GO:0048102; GO:0007049; GO:0008219; GO:0071236; GO:0071456; GO:0071285; GO:0071407; GO:0090398; GO:0006977; GO:1904019; GO:0060767; GO:0000082; GO:0007507; GO:0048839; GO:0051179; GO:1905179; GO:1902807; GO:0030308; GO:0008285; GO:1904030; GO:0045736; GO:0045892; GO:1904036; GO:0050680; GO:0060770; GO:0033673; GO:0045930; GO:0042326; GO:1904706; GO:0007219; GO:0051168; GO:0001890; GO:0010942; GO:0008284; GO:0045737; GO:0031116; GO:0045732; GO:1904668; GO:0006813; GO:0051726; GO:1902806; GO:0000079; GO:0007096; GO:2000045; GO:1902746; GO:0060255; GO:0007346; GO:0043200; GO:0046686; GO:0032355; GO:0009749; GO:0001666; GO:0014070; GO:0043434; GO:0009410; GO:0007605","PTHR10265:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1785|UniProtKB=P46527","P00036"]
["p27-Kip1 (CDKN1B) - phospho","Thr187","CDKN1B","27","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1988",".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRR., .EGFR., .FOXO., .HIF., .INT., .NOTCH., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR.","Interleukin signaling pathway","CYCLIN-DEPENDENT KINASE INHIBITOR 1B","apoptotic process; autophagic cell death; cell cycle; cell death; cellular response to antibiotic; cellular response to hypoxia; cellular response to lithium ion; cellular response to organic cyclic compound; cellular senescence; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epithelial cell apoptotic process; epithelial cell proliferation involved in prostate gland development; G1/S transition of mitotic cell cycle; heart development; inner ear development; localization; negative regulation of cardiac muscle tissue regeneration; negative regulation of cell cycle G1/S phase transition; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell apoptotic process; negative regulation of epithelial cell proliferation; negative regulation of epithelial cell proliferation involved in prostate gland development; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of vascular associated smooth muscle cell proliferation; Notch signaling pathway; nuclear export; placenta development; positive regulation of cell death; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of ubiquitin protein ligase activity; potassium ion transport; regulation of cell cycle; regulation of cell cycle G1/S phase transition; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of exit from mitosis; regulation of G1/S transition of mitotic cell cycle; regulation of lens fiber cell differentiation; regulation of macromolecule metabolic process; regulation of mitotic cell cycle; response to amino acid; response to cadmium ion; response to estradiol; response to glucose; response to hypoxia; response to organic cyclic compound; response to peptide hormone; response to xenobiotic stimulus; sensory perception of sound","chaperone binding; cyclin binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; Hsp70 protein binding; molecular adaptor activity; molecular function inhibitor activity; protein binding; protein kinase binding; protein kinase inhibitor activity; protein phosphatase binding; protein-containing complex binding; ubiquitin ligase activator activity; ubiquitin protein ligase binding","Cul4A-RING E3 ubiquitin ligase complex; cytoplasm; cytosol; endosome; intracellular membrane-bounded organelle; nucleoplasm; nucleus; protein-containing complex","Cell cycle control","cyclin dependent kinase inhibitor 1B","http://www.ncbi.nlm.nih.gov/gene/?term=1027","1027","12576","83571","403429",null,null,"P46527","P46414","O08769","F1PGU6",null,null,"GO:0031464; GO:0005737; GO:0005829; GO:0005768; GO:0043231; GO:0005654; GO:0005634; GO:0032991","GO:0051087; GO:0030332; GO:0004861; GO:0030544; GO:0060090; GO:0140678; GO:0005515; GO:0019901; GO:0004860; GO:0019903; GO:0044877; GO:1990757; GO:0031625","GO:0006915; GO:0048102; GO:0007049; GO:0008219; GO:0071236; GO:0071456; GO:0071285; GO:0071407; GO:0090398; GO:0006977; GO:1904019; GO:0060767; GO:0000082; GO:0007507; GO:0048839; GO:0051179; GO:1905179; GO:1902807; GO:0030308; GO:0008285; GO:1904030; GO:0045736; GO:0045892; GO:1904036; GO:0050680; GO:0060770; GO:0033673; GO:0045930; GO:0042326; GO:1904706; GO:0007219; GO:0051168; GO:0001890; GO:0010942; GO:0008284; GO:0045737; GO:0031116; GO:0045732; GO:1904668; GO:0006813; GO:0051726; GO:1902806; GO:0000079; GO:0007096; GO:2000045; GO:1902746; GO:0060255; GO:0007346; GO:0043200; GO:0046686; GO:0032355; GO:0009749; GO:0001666; GO:0014070; GO:0043434; GO:0009410; GO:0007605","PTHR10265:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1785|UniProtKB=P46527","P00036"]
["p300 (EP300) - phospho","Ser89","EP300","280","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1285",".APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CSP., .DEV., .DI., .FOXO., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .NFKB., .NOTCH., .OP., .OPA., .OT., .P53S., .PRC., .RCC., .RTK., .SREME., .ST., .STAT., .TGFB., .TRASR., .VIR., .WNT.","Transcription regulation by bZIP transcription factor; p53 pathway; TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway; Huntington disease; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Wnt signaling pathway","HISTONE ACETYLTRANSFERASE P300","animal organ morphogenesis; apoptotic process; B cell differentiation; behavioral defense response; cell cycle; cellular response to UV; chromatin remodeling; circadian rhythm; face morphogenesis; fat cell differentiation; heart development; histone acetylation; internal peptidyl-lysine acetylation; internal protein amino acid acetylation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; learning or memory; lung development; macrophage derived foam cell differentiation; megakaryocyte development; multicellular organism growth; negative regulation of gluconeogenesis; negative regulation of protein-containing complex assembly; negative regulation of transcription by RNA polymerase II; nervous system development; N-terminal peptidyl-lysine acetylation; peptidyl-lysine acetylation; peptidyl-lysine butyrylation; peptidyl-lysine crotonylation; peptidyl-lysine propionylation; platelet formation; positive regulation by host of viral transcription; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of protein binding; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; protein acetylation; protein destabilization; protein stabilization; regulation of androgen receptor signaling pathway; regulation of autophagy; regulation of cellular response to heat; regulation of DNA-templated transcription; regulation of glycolytic process; regulation of mitochondrion organization; regulation of signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II; regulation of tubulin deacetylation; response to estrogen; response to hypoxia; response to stimulus; rhythmic process; skeletal muscle tissue development; somitogenesis; stimulatory C-type lectin receptor signaling pathway; swimming; thigmotaxis; transcription by RNA polymerase II; transcription initiation-coupled chromatin remodeling","acetyltransferase activity; acyltransferase activity; beta-catenin binding; chromatin binding; chromatin DNA binding; damaged DNA binding; DNA binding; DNA-binding transcription factor binding; histone acetyltransferase activity; histone butyryltransferase activity; histone crotonyltransferase activity; histone H2B acetyltransferase activity; histone H3 acetyltransferase activity; histone H3K122 acetyltransferase activity; histone H4 acetyltransferase activity; histone lactyltransferase activity; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; metal ion binding; NF-kappaB binding; nuclear androgen receptor binding; nuclear receptor binding; p53 binding; peptide 2-hydroxyisobutyryltransferase activity; peptide butyryltransferase activity; peptide crotonyltransferase activity; peptide lactyltransferase activity; peptide N-acetyltransferase activity; peptide-lysine-N-acetyltransferase activity; pre-mRNA intronic binding; protein binding; protein C-terminus binding; protein propionyltransferase activity; RNA polymerase II-specific DNA-binding transcription factor binding; STAT family protein binding; tau protein binding; transcription coactivator activity; transcription coactivator binding; transcription coregulator activity; transcription coregulator binding; transferase activity; zinc ion binding","chromosome; cytoplasm; cytosol; histone acetyltransferase complex; intracellular organelle; nucleoplasm; nucleus; protein-containing complex; protein-DNA complex; transcription regulator complex","Chromatin regulation / epigenetics","E1A binding protein p300","http://www.ncbi.nlm.nih.gov/gene/?term=2033","2033","328572",null,null,null,null,"Q09472","B2RWS6","A0A0G2QC09","A0A8I3NW07","A0A8W4FCE1","A0A1D5QCQ3","GO:0005694; GO:0005737; GO:0005829; GO:0000123; GO:0043229; GO:0005654; GO:0005634; GO:0032991; GO:0032993; GO:0005667","GO:0016407; GO:0016746; GO:0008013; GO:0003682; GO:0031490; GO:0003684; GO:0003677; GO:0140297; GO:0004402; GO:0140069; GO:0140068; GO:0044013; GO:0010484; GO:0140908; GO:0010485; GO:0120301; GO:0004468; GO:0046872; GO:0051059; GO:0050681; GO:0016922; GO:0002039; GO:0106226; GO:0140065; GO:0140064; GO:0120300; GO:0034212; GO:0061733; GO:0097157; GO:0005515; GO:0008022; GO:0061920; GO:0061629; GO:0097677; GO:0048156; GO:0003713; GO:0001223; GO:0003712; GO:0001221; GO:0016740; GO:0008270","GO:0009887; GO:0006915; GO:0030183; GO:0002209; GO:0007049; GO:0034644; GO:0006338; GO:0007623; GO:0060325; GO:0045444; GO:0007507; GO:0016573; GO:0018393; GO:0006475; GO:0042771; GO:0007611; GO:0030324; GO:0010742; GO:0035855; GO:0035264; GO:0045721; GO:0031333; GO:0000122; GO:0007399; GO:0018076; GO:0018394; GO:0140067; GO:0140066; GO:0061921; GO:0030220; GO:0043923; GO:0051091; GO:0045893; GO:0010628; GO:0010976; GO:0051092; GO:1901224; GO:0032092; GO:1905636; GO:0045944; GO:0030511; GO:0006473; GO:0031648; GO:0050821; GO:0060765; GO:0010506; GO:1900034; GO:0006355; GO:0006110; GO:0010821; GO:1901796; GO:0006357; GO:0090043; GO:0043627; GO:0001666; GO:0050896; GO:0048511; GO:0007519; GO:0001756; GO:0002223; GO:0036268; GO:0001966; GO:0006366; GO:0045815","PTHR13808:SF29","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3373|UniProtKB=Q09472","P00055; P00059; P00052; P06664; P00029; P00026; P00057"]
["p38 MAPK",null,"MAPK14","43","rb",null,1,2,1,1.1000000000000001,1.1000000000000001,1.1000000000000001,"# 2021",".ALZ., .ANG., .APO., .BCR., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .DI., .DRR., .EGFR., .FGFR., .FOXO., .HEPB., .HIPPO., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .P53S., .PARK., .PLAT., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VEGFS., .VIR., .WNT.","CCKR signaling map; p38 MAPK pathway; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; JAK/STAT signaling pathway; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; p53 pathway feedback loops 2","MITOGEN-ACTIVATED PROTEIN KINASE 14","3'-UTR-mediated mRNA stabilization; angiogenesis; apoptotic process; bone development; cartilage condensation; cell morphogenesis; cell surface receptor signaling pathway; cellular response to DNA damage stimulus; cellular response to ionizing radiation; cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; cellular response to tumor necrosis factor; cellular response to UV-B; cellular response to vascular endothelial growth factor stimulus; cellular response to virus; cellular senescence; chemotaxis; chondrocyte differentiation; DNA damage checkpoint signaling; fatty acid oxidation; glucose import; glucose metabolic process; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of hippo signaling; negative regulation of inflammatory response to antigenic stimulus; osteoblast differentiation; osteoclast differentiation; p38MAPK cascade; peptidyl-serine phosphorylation; phosphorylation; placenta development; platelet activation; positive regulation of blood vessel endothelial cell migration; positive regulation of brown fat cell differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of cyclase activity; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of glucose import; positive regulation of interleukin-12 production; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of myoblast fusion; positive regulation of myotube differentiation; positive regulation of protein import into nucleus; positive regulation of reactive oxygen species metabolic process; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of cytokine production involved in inflammatory response; regulation of DNA-templated transcription; regulation of ossification; regulation of synaptic membrane adhesion; regulation of transcription by RNA polymerase II; response to dietary excess; response to insulin; response to lipopolysaccharide; response to muramyl dipeptide; response to muscle stretch; signal transduction; signal transduction in response to DNA damage; skeletal muscle tissue development; stem cell differentiation; stress-activated MAPK cascade; stress-induced premature senescence; striated muscle cell differentiation; transcription by RNA polymerase II; transmembrane receptor protein serine/threonine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","ATP binding; enzyme binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase p38 binding; NFAT protein binding; nucleotide binding; phosphatase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transcription regulator activator activity; transferase activity","cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; glutamatergic synapse; mitochondrion; nuclear speck; nucleoplasm; nucleus; secretory granule lumen; spindle pole","MAPK signaling","mitogen-activated protein kinase 14","http://www.ncbi.nlm.nih.gov/gene/?term=1432","1432","26416",null,null,"100156630","718976","Q16539","P47811","A0A8I5ZT48","A0A8I3MXK0","A0A287AX01","F6V370","GO:0005737; GO:0005829; GO:0005576; GO:1904813; GO:0098978; GO:0005739; GO:0016607; GO:0005654; GO:0005634; GO:0034774; GO:0000922","GO:0005524; GO:0019899; GO:0016301; GO:0004707; GO:0004708; GO:0048273; GO:0051525; GO:0000166; GO:0019211; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0140537; GO:0016740","GO:0070935; GO:0001525; GO:0006915; GO:0060348; GO:0001502; GO:0000902; GO:0007166; GO:0006974; GO:0071479; GO:0071222; GO:0071223; GO:0071356; GO:0071493; GO:0035924; GO:0098586; GO:0090398; GO:0006935; GO:0002062; GO:0000077; GO:0019395; GO:0046323; GO:0006006; GO:0035556; GO:0031663; GO:0000165; GO:0090090; GO:0035331; GO:0002862; GO:0001649; GO:0030316; GO:0038066; GO:0018105; GO:0016310; GO:0001890; GO:0030168; GO:0043536; GO:0090336; GO:0060045; GO:0031281; GO:0045648; GO:0010628; GO:0046326; GO:0032735; GO:0051149; GO:0045663; GO:1901741; GO:0010831; GO:0042307; GO:2000379; GO:0045944; GO:0006468; GO:1900015; GO:0006355; GO:0030278; GO:0099179; GO:0006357; GO:0002021; GO:0032868; GO:0032496; GO:0032495; GO:0035994; GO:0007165; GO:0042770; GO:0007519; GO:0048863; GO:0051403; GO:0090400; GO:0051146; GO:0006366; GO:0007178; GO:0048010","PTHR24055:SF110","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6876|UniProtKB=Q16539","P06959; P05918; P00052; P00010; P00056; P06664; P00021; P04393; P00035; P00038; P00005; P00054; P00049; P00046; P00018; P00003; P04398"]
["p38 MAPK - phospho","Thr180/Tyr182","MAPK14","43","rb",null,2,1,1,8,8,8,"# 1223",".ALZ., .ANG., .APO., .BCR., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .DI., .DRR., .EGFR., .FGFR., .FOXO., .HEPB., .HIPPO., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .P53S., .PARK., .PLAT., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VEGFS., .VIR., .WNT.","CCKR signaling map; p38 MAPK pathway; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; JAK/STAT signaling pathway; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; p53 pathway feedback loops 2","MITOGEN-ACTIVATED PROTEIN KINASE 14","3'-UTR-mediated mRNA stabilization; angiogenesis; apoptotic process; bone development; cartilage condensation; cell morphogenesis; cell surface receptor signaling pathway; cellular response to DNA damage stimulus; cellular response to ionizing radiation; cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; cellular response to tumor necrosis factor; cellular response to UV-B; cellular response to vascular endothelial growth factor stimulus; cellular response to virus; cellular senescence; chemotaxis; chondrocyte differentiation; DNA damage checkpoint signaling; fatty acid oxidation; glucose import; glucose metabolic process; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of hippo signaling; negative regulation of inflammatory response to antigenic stimulus; osteoblast differentiation; osteoclast differentiation; p38MAPK cascade; peptidyl-serine phosphorylation; phosphorylation; placenta development; platelet activation; positive regulation of blood vessel endothelial cell migration; positive regulation of brown fat cell differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of cyclase activity; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of glucose import; positive regulation of interleukin-12 production; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of myoblast fusion; positive regulation of myotube differentiation; positive regulation of protein import into nucleus; positive regulation of reactive oxygen species metabolic process; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of cytokine production involved in inflammatory response; regulation of DNA-templated transcription; regulation of ossification; regulation of synaptic membrane adhesion; regulation of transcription by RNA polymerase II; response to dietary excess; response to insulin; response to lipopolysaccharide; response to muramyl dipeptide; response to muscle stretch; signal transduction; signal transduction in response to DNA damage; skeletal muscle tissue development; stem cell differentiation; stress-activated MAPK cascade; stress-induced premature senescence; striated muscle cell differentiation; transcription by RNA polymerase II; transmembrane receptor protein serine/threonine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","ATP binding; enzyme binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase p38 binding; NFAT protein binding; nucleotide binding; phosphatase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transcription regulator activator activity; transferase activity","cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; glutamatergic synapse; mitochondrion; nuclear speck; nucleoplasm; nucleus; secretory granule lumen; spindle pole","MAPK signaling","mitogen-activated protein kinase 14","http://www.ncbi.nlm.nih.gov/gene/?term=1432","1432","26416",null,null,"100156630","718976","Q16539","P47811","A0A8I5ZT48","A0A8I3MXK0","A0A287AX01","F6V370","GO:0005737; GO:0005829; GO:0005576; GO:1904813; GO:0098978; GO:0005739; GO:0016607; GO:0005654; GO:0005634; GO:0034774; GO:0000922","GO:0005524; GO:0019899; GO:0016301; GO:0004707; GO:0004708; GO:0048273; GO:0051525; GO:0000166; GO:0019211; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0140537; GO:0016740","GO:0070935; GO:0001525; GO:0006915; GO:0060348; GO:0001502; GO:0000902; GO:0007166; GO:0006974; GO:0071479; GO:0071222; GO:0071223; GO:0071356; GO:0071493; GO:0035924; GO:0098586; GO:0090398; GO:0006935; GO:0002062; GO:0000077; GO:0019395; GO:0046323; GO:0006006; GO:0035556; GO:0031663; GO:0000165; GO:0090090; GO:0035331; GO:0002862; GO:0001649; GO:0030316; GO:0038066; GO:0018105; GO:0016310; GO:0001890; GO:0030168; GO:0043536; GO:0090336; GO:0060045; GO:0031281; GO:0045648; GO:0010628; GO:0046326; GO:0032735; GO:0051149; GO:0045663; GO:1901741; GO:0010831; GO:0042307; GO:2000379; GO:0045944; GO:0006468; GO:1900015; GO:0006355; GO:0030278; GO:0099179; GO:0006357; GO:0002021; GO:0032868; GO:0032496; GO:0032495; GO:0035994; GO:0007165; GO:0042770; GO:0007519; GO:0048863; GO:0051403; GO:0090400; GO:0051146; GO:0006366; GO:0007178; GO:0048010","PTHR24055:SF110","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6876|UniProtKB=Q16539","P06959; P05918; P00052; P00010; P00056; P06664; P00021; P04393; P00035; P00038; P00005; P00054; P00049; P00046; P00018; P00003; P04398"]
["p38 MAPK alpha",null,"MAPK14","40","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1684",".ALZ., .ANG., .APO., .BCR., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .DI., .DRR., .EGFR., .FGFR., .FOXO., .HEPB., .HIPPO., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .P53S., .PARK., .PLAT., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VEGFS., .VIR., .WNT.","CCKR signaling map; p38 MAPK pathway; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; JAK/STAT signaling pathway; Angiogenesis; Toll receptor signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; p53 pathway feedback loops 2","MITOGEN-ACTIVATED PROTEIN KINASE 14","3'-UTR-mediated mRNA stabilization; angiogenesis; apoptotic process; bone development; cartilage condensation; cell morphogenesis; cell surface receptor signaling pathway; cellular response to DNA damage stimulus; cellular response to ionizing radiation; cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; cellular response to tumor necrosis factor; cellular response to UV-B; cellular response to vascular endothelial growth factor stimulus; cellular response to virus; cellular senescence; chemotaxis; chondrocyte differentiation; DNA damage checkpoint signaling; fatty acid oxidation; glucose import; glucose metabolic process; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of hippo signaling; negative regulation of inflammatory response to antigenic stimulus; osteoblast differentiation; osteoclast differentiation; p38MAPK cascade; peptidyl-serine phosphorylation; phosphorylation; placenta development; platelet activation; positive regulation of blood vessel endothelial cell migration; positive regulation of brown fat cell differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of cyclase activity; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of glucose import; positive regulation of interleukin-12 production; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of myoblast fusion; positive regulation of myotube differentiation; positive regulation of protein import into nucleus; positive regulation of reactive oxygen species metabolic process; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of cytokine production involved in inflammatory response; regulation of DNA-templated transcription; regulation of ossification; regulation of synaptic membrane adhesion; regulation of transcription by RNA polymerase II; response to dietary excess; response to insulin; response to lipopolysaccharide; response to muramyl dipeptide; response to muscle stretch; signal transduction; signal transduction in response to DNA damage; skeletal muscle tissue development; stem cell differentiation; stress-activated MAPK cascade; stress-induced premature senescence; striated muscle cell differentiation; transcription by RNA polymerase II; transmembrane receptor protein serine/threonine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway","ATP binding; enzyme binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase p38 binding; NFAT protein binding; nucleotide binding; phosphatase activator activity; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transcription regulator activator activity; transferase activity","cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; glutamatergic synapse; mitochondrion; nuclear speck; nucleoplasm; nucleus; secretory granule lumen; spindle pole","MAPK signaling","mitogen-activated protein kinase 14","http://www.ncbi.nlm.nih.gov/gene/?term=1432","1432","26416",null,null,"100156630","718976","Q16539","P47811","A0A8I5ZT48","A0A8I3MXK0","A0A287AX01","F6V370","GO:0005737; GO:0005829; GO:0005576; GO:1904813; GO:0098978; GO:0005739; GO:0016607; GO:0005654; GO:0005634; GO:0034774; GO:0000922","GO:0005524; GO:0019899; GO:0016301; GO:0004707; GO:0004708; GO:0048273; GO:0051525; GO:0000166; GO:0019211; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0140537; GO:0016740","GO:0070935; GO:0001525; GO:0006915; GO:0060348; GO:0001502; GO:0000902; GO:0007166; GO:0006974; GO:0071479; GO:0071222; GO:0071223; GO:0071356; GO:0071493; GO:0035924; GO:0098586; GO:0090398; GO:0006935; GO:0002062; GO:0000077; GO:0019395; GO:0046323; GO:0006006; GO:0035556; GO:0031663; GO:0000165; GO:0090090; GO:0035331; GO:0002862; GO:0001649; GO:0030316; GO:0038066; GO:0018105; GO:0016310; GO:0001890; GO:0030168; GO:0043536; GO:0090336; GO:0060045; GO:0031281; GO:0045648; GO:0010628; GO:0046326; GO:0032735; GO:0051149; GO:0045663; GO:1901741; GO:0010831; GO:0042307; GO:2000379; GO:0045944; GO:0006468; GO:1900015; GO:0006355; GO:0030278; GO:0099179; GO:0006357; GO:0002021; GO:0032868; GO:0032496; GO:0032495; GO:0035994; GO:0007165; GO:0042770; GO:0007519; GO:0048863; GO:0051403; GO:0090400; GO:0051146; GO:0006366; GO:0007178; GO:0048010","PTHR24055:SF110","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6876|UniProtKB=Q16539","P06959; P05918; P00052; P00010; P00056; P06664; P00021; P04393; P00035; P00038; P00005; P00054; P00049; P00046; P00018; P00003; P04398"]
["p38 MAPK beta",null,"MAPK11","43","rb",null,4,2,"n/a","n/a","n/a","n/a","# 1688",".ALZ., .BCR., .CCP., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .FGFR., .FOXO., .HEPB., .IMUF., .IMUR., .INFG., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .P53S., .PLAT., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VEGFS., .VIR.","p38 MAPK pathway; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; p53 pathway feedback loops 2","MITOGEN-ACTIVATED PROTEIN KINASE 11","bone development; cardiac muscle cell proliferation; cellular response to interleukin-1; cellular response to UV-B; cellular response to virus; cellular senescence; intracellular signal transduction; MAPK cascade; negative regulation of cardiac muscle cell proliferation; osteoblast differentiation; p38MAPK cascade; phosphorylation; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of interleukin-12 production; positive regulation of muscle cell differentiation; protein phosphorylation; regulation of cardiac muscle cell proliferation; stress-activated MAPK cascade","ATP binding; kinase activity; MAP kinase activity; nucleotide binding; phosphatase activator activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transcription regulator activator activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus",null,"mitogen-activated protein kinase 11","http://www.ncbi.nlm.nih.gov/gene/?term=5600","5600","19094","689314",null,null,"715794","Q15759","Q9WUI1","A0A0G2KB06",null,null,"F7C798","GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0005524; GO:0016301; GO:0004707; GO:0000166; GO:0019211; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0140537; GO:0016740","GO:0060348; GO:0060038; GO:0071347; GO:0071493; GO:0098586; GO:0090398; GO:0035556; GO:0000165; GO:0060044; GO:0001649; GO:0038066; GO:0016310; GO:0045648; GO:0010628; GO:0032735; GO:0051149; GO:0006468; GO:0060043; GO:0051403","PTHR24055:SF109","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6873|UniProtKB=Q15759","P05918; P00052; P00010; P06664; P00021; P04393; P00035; P00046; P00018; P00003; P04398"]
["p38 MAPK delta",null,"MAPK13","43","rb",null,1,4,"n/a","n/a","n/a","n/a","# 1689",".ALZ., .BCR., .CCP., .CCY., .CD., .CSP., .DEV., .DI., .EGFR., .FGFR., .FOXO., .HEPB., .IMFR., .IMUF., .IMUR., .INFG., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .P53S., .PLAT., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VEGFS.","p38 MAPK pathway; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Integrin signalling pathway; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; p53 pathway feedback loops 2","MITOGEN-ACTIVATED PROTEIN KINASE 13","cell cycle; cellular response to anisomycin; cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to sodium arsenite; cellular response to sorbitol; cellular response to UV; intracellular signal transduction; MAPK cascade; peptidyl-serine phosphorylation; phosphorylation; positive regulation of inflammatory response; positive regulation of interleukin-6 production; protein phosphorylation; response to osmotic stress; stress-activated MAPK cascade","ATP binding; kinase activity; MAP kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; nucleus",null,"mitogen-activated protein kinase 13","http://www.ncbi.nlm.nih.gov/gene/?term=5603","5603","26415",null,null,null,null,"O15264","Q9Z1B7","G3V618","A0A8I3MZM9",null,"A0A1D5QC76","GO:0005737; GO:0005829; GO:0005634","GO:0005524; GO:0016301; GO:0004707; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0072740; GO:0070301; GO:0071347; GO:1903936; GO:0072709; GO:0034644; GO:0035556; GO:0000165; GO:0018105; GO:0016310; GO:0050729; GO:0032755; GO:0006468; GO:0006970; GO:0051403","PTHR24055:SF107","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6875|UniProtKB=O15264","P05918; P00052; P00010; P06664; P00021; P04393; P00035; P00034; P00046; P00018; P00003; P04398"]
["p38 MAPK gamma",null,"MAPK12","46","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1695",".ALZ., .BCR., .CCP., .CCY., .CD., .CSP., .DDR., .DEV., .DI., .EGFR., .FGFR., .FOXO., .HEPB., .IMUF., .INFG., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .P53S., .PARK., .PLAT., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .VEGFS.","p38 MAPK pathway; TGF-beta signaling pathway; B cell activation; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; Parkinson disease; Oxidative stress response; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; p53 pathway feedback loops 2","MITOGEN-ACTIVATED PROTEIN KINASE 12","cell cycle; intracellular signal transduction; MAPK cascade; muscle organ development; myoblast differentiation; negative regulation of cell cycle; peptidyl-serine phosphorylation; phosphorylation; positive regulation of muscle cell differentiation; positive regulation of peptidase activity; protein phosphorylation; regulation of cell cycle; signal transduction; signal transduction in response to DNA damage","ATP binding; kinase activity; magnesium ion binding; MAP kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus",null,"mitogen-activated protein kinase 12","http://www.ncbi.nlm.nih.gov/gene/?term=6300","6300","29857","60352",null,null,null,"P53778","O08911","Q63538","A0A8I3N1Y2",null,"A0A1D5Q2M1","GO:0005737; GO:0005829; GO:0005739; GO:0005654; GO:0005634","GO:0005524; GO:0016301; GO:0000287; GO:0004707; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0035556; GO:0000165; GO:0007517; GO:0045445; GO:0045786; GO:0018105; GO:0016310; GO:0051149; GO:0010952; GO:0006468; GO:0051726; GO:0007165; GO:0042770","PTHR24055:SF146","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6874|UniProtKB=P53778","P05918; P00052; P00010; P06664; P00021; P04393; P00035; P00049; P00046; P00018; P00003; P04398"]
["p53",null,"TP53","53","gt",null,1,6,2,2,6.1,6.1,"TK # 001",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53",null,"TP53","53","rb",null,6,1,2,6,8,8,"# 2167",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53",null,"TP53","53","ms",null,1,1,"n/a","n/a","n/a","n/a","# 2762",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - acetyl","Lys305","TP53","44","rb",null,1.1000000000000001,1,1,1,3,3,"# 1274",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - acetyl","Lys382","TP53","53","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1269",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - phospho","Ser15","TP53","53","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1164",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - phospho","Ser15","TP53","53","ms",null,3,2.1,8,8,8,8,"# 1828",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - phospho","Ser20","TP53","53","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1213",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - phospho","Ser37","TP53","53","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2063",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - phospho","Ser392","TP53","53","rb",null,4,4,8,8,8,8,"# 2482",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - phospho","Ser46","TP53","53","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2402",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - phospho","Ser46","TP53","53","rb",null,2,2.1,4,4,4,4,"BG/MP # 101",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - phospho","Ser6","TP53","53","rb",null,6.1,4,"n/a","n/a","n/a","n/a","# 1786",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 - phospho","Ser9","TP53","53","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1788",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53 mutant",null,"TP53","44","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1657",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p53Ab1",null,"TP53","0","ms",null,4,2,"n/a","n/a","n/a","n/a","# 1812",".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2; Wnt signaling pathway; Apoptosis signaling pathway","CELLULAR TUMOR ANTIGEN P53","apoptotic process; autophagy; B cell lineage commitment; bone marrow development; cardiac muscle cell apoptotic process; cardiac septum morphogenesis; cell cycle; cell population proliferation; cellular response to actinomycin D; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to UV; cellular response to UV-C; cellular response to xenobiotic stimulus; cellular senescence; central nervous system development; cerebellum development; chromosome organization; circadian behavior; circadian rhythm; determination of adult lifespan; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; embryo development ending in birth or egg hatching; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; fibroblast proliferation; gastrulation; glial cell proliferation; glucose catabolic process to lactate via pyruvate; heart development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; in utero embryonic development; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial DNA repair; mitophagy; mitotic G1 DNA damage checkpoint signaling; mRNA transcription; multicellular organism growth; necroptotic process; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA replication; negative regulation of DNA-templated transcription; negative regulation of fibroblast proliferation; negative regulation of G1 to G0 transition; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of helicase activity; negative regulation of miRNA maturation; negative regulation of mitophagy; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of pentose-phosphate shunt; negative regulation of proteolysis; negative regulation of reactive oxygen species metabolic process; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuroblast proliferation; neuron apoptotic process; nucleotide-excision repair; oligodendrocyte apoptotic process; oxidative stress-induced premature senescence; positive regulation of apoptotic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cellular senescence; positive regulation of DNA-templated transcription; positive regulation of execution phase of apoptosis; positive regulation of gene expression; positive regulation of histone deacetylation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane permeability; positive regulation of neuron apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of programmed necrotic cell death; positive regulation of reactive oxygen species metabolic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of thymocyte apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; programmed cell death; protein import into nucleus; protein localization; protein stabilization; protein tetramerization; protein-containing complex assembly; Ras protein signal transduction; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of cell cycle; regulation of cell cycle G2/M phase transition; regulation of cell population proliferation; regulation of cellular senescence; regulation of DNA damage response, signal transduction by p53 class mediator; regulation of DNA-templated transcription; regulation of fibroblast apoptotic process; regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of thymocyte apoptotic process; regulation of tissue remodeling; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to DNA damage; release of cytochrome c from mitochondria; replicative senescence; response to antibiotic; response to gamma radiation; response to inorganic substance; response to ischemia; response to oxidative stress; response to salt stress; response to UV; response to xenobiotic stimulus; response to X-ray; rhythmic process; rRNA transcription; signal transduction by p53 class mediator; somitogenesis; stem cell proliferation; T cell differentiation in thymus; T cell lineage commitment; T cell proliferation involved in immune response; thymocyte apoptotic process; transcription initiation-coupled chromatin remodeling; transforming growth factor beta receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; type II interferon-mediated signaling pathway; viral process","14-3-3 protein binding; ATP-dependent DNA/DNA annealing activity; chaperone binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; copper ion binding; core promoter sequence-specific DNA binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; general transcription initiation factor binding; histone acetyltransferase binding; histone deacetylase binding; histone deacetylase regulator activity; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; molecular function activator activity; mRNA 3'-UTR binding; p53 binding; promoter-specific chromatin binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; TFIID-class transcription factor complex binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding; zinc ion binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear body; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein-containing complex; replication fork; site of double-strand break; transcription regulator complex; transcription repressor complex","Cell cycle control / tumor suppressor","tumor protein p53","http://www.ncbi.nlm.nih.gov/gene/?term=7157","7157","22059",null,null,"397276",null,"P04637","P02340",null,"A0A8I3PMM3","Q9TUB2","A0A1I7Q490","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0043073; GO:0005815; GO:0005759; GO:0005739; GO:0016604; GO:0016363; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0032991; GO:0005657; GO:0035861; GO:0005667; GO:0017053","GO:0071889; GO:0036310; GO:0051087; GO:0003682; GO:0000987; GO:0005507; GO:0001046; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0019899; GO:0140296; GO:0035035; GO:0042826; GO:0035033; GO:0042802; GO:0097371; GO:0046872; GO:0140677; GO:0003730; GO:0002039; GO:1990841; GO:0002020; GO:0005515; GO:0046982; GO:0019901; GO:0047485; GO:0051721; GO:0019903; GO:0043621; GO:0030971; GO:0000978; GO:0000977; GO:0061629; GO:0001094; GO:0000976; GO:0031625; GO:0008270","GO:0006915; GO:0006914; GO:0002326; GO:0048539; GO:0010659; GO:0060411; GO:0007049; GO:0008283; GO:0072717; GO:0006974; GO:0071480; GO:0042149; GO:0071456; GO:0071479; GO:0034644; GO:0071494; GO:0071466; GO:0090398; GO:0007417; GO:0021549; GO:0051276; GO:0048512; GO:0007623; GO:0008340; GO:0030330; GO:0006977; GO:0006978; GO:0006302; GO:0009792; GO:0048568; GO:0043153; GO:0006983; GO:0048144; GO:0007369; GO:0014009; GO:0019661; GO:0007507; GO:0002244; GO:0060218; GO:0001701; GO:0097193; GO:0072332; GO:0042771; GO:0070059; GO:1990144; GO:0043504; GO:0000423; GO:0031571; GO:0009299; GO:0035264; GO:0070266; GO:0043066; GO:0030308; GO:0008285; GO:0008156; GO:0045892; GO:0048147; GO:1903451; GO:0010629; GO:0060253; GO:1904024; GO:0051097; GO:1903799; GO:1901525; GO:0045930; GO:0007406; GO:1905856; GO:0045861; GO:2000378; GO:2000647; GO:0051974; GO:0000122; GO:0030512; GO:0007405; GO:0051402; GO:0006289; GO:0097252; GO:0090403; GO:0043065; GO:0010666; GO:2000774; GO:0045893; GO:1900119; GO:0010628; GO:0031065; GO:2001244; GO:1902895; GO:0035794; GO:0043525; GO:0050731; GO:0062100; GO:2000379; GO:0090200; GO:0045899; GO:0070245; GO:0045944; GO:1990440; GO:0061419; GO:0036003; GO:0012501; GO:0006606; GO:0008104; GO:0050821; GO:0051262; GO:0065003; GO:0007265; GO:0072593; GO:0042981; GO:0051726; GO:1902749; GO:0042127; GO:2000772; GO:0043516; GO:0006355; GO:2000269; GO:1902253; GO:1902108; GO:0007346; GO:0043523; GO:0070243; GO:0034103; GO:0006357; GO:1990248; GO:0001836; GO:0090399; GO:0046677; GO:0010332; GO:0010035; GO:0002931; GO:0006979; GO:0009651; GO:0009411; GO:0009410; GO:0010165; GO:0048511; GO:0009303; GO:0072331; GO:0001756; GO:0072089; GO:0033077; GO:0002360; GO:0002309; GO:0070242; GO:0045815; GO:0007179; GO:0033209; GO:0060333; GO:0016032","PTHR11447:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11998|UniProtKB=P04637","P00059; P04397; P04392; P00029; P04398; P00057; P00006"]
["p70 S6 kinase",null,"RPS6KB1","85, 70","rb",null,1,1,1,2,1,2,"BG/MP # 056",".AML., .AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRR., .EGFR., .HIF., .IIR., .IMUR., .INS., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .RAS., .RTK., .SREME., .ST., .TGFB., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p53 pathway by glucose deprivation; Ras Pathway; PDGF signaling pathway; PI3 kinase pathway","RIBOSOMAL PROTEIN S6 KINASE BETA-1","aging; apoptotic process; behavioral fear response; cell cycle; cell migration; cellular response to dexamethasone stimulus; cellular response to growth factor stimulus; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to organic cyclic compound; cellular response to type II interferon; G1/S transition of mitotic cell cycle; germ cell development; long-chain fatty acid import into cell; long-term memory; modulation of chemical synaptic transmission; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of mitotic cell cycle; positive regulation of skeletal muscle tissue growth; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of translation; positive regulation of translational initiation; protein kinase B signaling; protein phosphorylation; regulation of glucose import; regulation of translation; response to amino acid; response to electrical stimulus involved in regulation of muscle adaptation; response to ethanol; response to glucagon; response to glucocorticoid; response to glucose; response to heat; response to insulin; response to leucine; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to nutrient levels; response to organic cyclic compound; response to organic substance; response to organonitrogen compound; response to peptide hormone; response to testosterone; response to toxic substance; response to tumor necrosis factor; response to wounding; response to xenobiotic stimulus; signal transduction; skeletal muscle atrophy; skeletal muscle contraction; TOR signaling","ATP binding; identical protein binding; kinase activity; nucleotide binding; PDZ domain binding; peptide binding; protein binding; protein kinase activity; protein phosphatase 2A binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cell surface; cytoplasm; cytosol; glutamatergic synapse; membrane; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynapse; synapse","Translational control","ribosomal protein S6 kinase B1","http://www.ncbi.nlm.nih.gov/gene/?term=6198","6198","72508","83840",null,"100127158",null,"P23443","Q8BSK8","P67999","A0A8I3PNG8","A0A481C7T7","A0A1D5QKR7","GO:0009986; GO:0005737; GO:0005829; GO:0098978; GO:0016020; GO:0005741; GO:0005739; GO:0043005; GO:0005654; GO:0005634; GO:0048471; GO:0098794; GO:0045202","GO:0005524; GO:0042802; GO:0016301; GO:0000166; GO:0030165; GO:0042277; GO:0005515; GO:0004672; GO:0051721; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0007568; GO:0006915; GO:0001662; GO:0007049; GO:0016477; GO:0071549; GO:0071363; GO:0032870; GO:0032869; GO:0071407; GO:0071346; GO:0000082; GO:0007281; GO:0044539; GO:0007616; GO:0050804; GO:0043066; GO:2001237; GO:0046627; GO:0018105; GO:0048015; GO:0016310; GO:0045931; GO:0048633; GO:0014911; GO:0048661; GO:0045727; GO:0045948; GO:0043491; GO:0006468; GO:0046324; GO:0006417; GO:0043200; GO:0014878; GO:0045471; GO:0033762; GO:0051384; GO:0009749; GO:0009408; GO:0032868; GO:0043201; GO:0032496; GO:0009612; GO:0007584; GO:0031667; GO:0014070; GO:0010033; GO:0010243; GO:0043434; GO:0033574; GO:0009636; GO:0034612; GO:0009611; GO:0009410; GO:0007165; GO:0014732; GO:0003009; GO:0031929","PTHR24351:SF48","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10436|UniProtKB=P23443","P06959; P00032; P04397; P04393; P00047; P00048"]
["p70 S6 kinase - phospho","Thr389","RPS6KB1","85, 70","rb",null,2.1,8,8,8,8,8,"# 1211",".AML., .AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRR., .EGFR., .HIF., .IIR., .IMUR., .INS., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .RAS., .RTK., .SREME., .ST., .TGFB., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p53 pathway by glucose deprivation; Ras Pathway; PDGF signaling pathway; PI3 kinase pathway","RIBOSOMAL PROTEIN S6 KINASE BETA-1","aging; apoptotic process; behavioral fear response; cell cycle; cell migration; cellular response to dexamethasone stimulus; cellular response to growth factor stimulus; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to organic cyclic compound; cellular response to type II interferon; G1/S transition of mitotic cell cycle; germ cell development; long-chain fatty acid import into cell; long-term memory; modulation of chemical synaptic transmission; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of mitotic cell cycle; positive regulation of skeletal muscle tissue growth; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of translation; positive regulation of translational initiation; protein kinase B signaling; protein phosphorylation; regulation of glucose import; regulation of translation; response to amino acid; response to electrical stimulus involved in regulation of muscle adaptation; response to ethanol; response to glucagon; response to glucocorticoid; response to glucose; response to heat; response to insulin; response to leucine; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to nutrient levels; response to organic cyclic compound; response to organic substance; response to organonitrogen compound; response to peptide hormone; response to testosterone; response to toxic substance; response to tumor necrosis factor; response to wounding; response to xenobiotic stimulus; signal transduction; skeletal muscle atrophy; skeletal muscle contraction; TOR signaling","ATP binding; identical protein binding; kinase activity; nucleotide binding; PDZ domain binding; peptide binding; protein binding; protein kinase activity; protein phosphatase 2A binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cell surface; cytoplasm; cytosol; glutamatergic synapse; membrane; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynapse; synapse","Translational control","ribosomal protein S6 kinase B1","http://www.ncbi.nlm.nih.gov/gene/?term=6198","6198","72508","83840",null,"100127158",null,"P23443","Q8BSK8","P67999","A0A8I3PNG8","A0A481C7T7","A0A1D5QKR7","GO:0009986; GO:0005737; GO:0005829; GO:0098978; GO:0016020; GO:0005741; GO:0005739; GO:0043005; GO:0005654; GO:0005634; GO:0048471; GO:0098794; GO:0045202","GO:0005524; GO:0042802; GO:0016301; GO:0000166; GO:0030165; GO:0042277; GO:0005515; GO:0004672; GO:0051721; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0007568; GO:0006915; GO:0001662; GO:0007049; GO:0016477; GO:0071549; GO:0071363; GO:0032870; GO:0032869; GO:0071407; GO:0071346; GO:0000082; GO:0007281; GO:0044539; GO:0007616; GO:0050804; GO:0043066; GO:2001237; GO:0046627; GO:0018105; GO:0048015; GO:0016310; GO:0045931; GO:0048633; GO:0014911; GO:0048661; GO:0045727; GO:0045948; GO:0043491; GO:0006468; GO:0046324; GO:0006417; GO:0043200; GO:0014878; GO:0045471; GO:0033762; GO:0051384; GO:0009749; GO:0009408; GO:0032868; GO:0043201; GO:0032496; GO:0009612; GO:0007584; GO:0031667; GO:0014070; GO:0010033; GO:0010243; GO:0043434; GO:0033574; GO:0009636; GO:0034612; GO:0009611; GO:0009410; GO:0007165; GO:0014732; GO:0003009; GO:0031929","PTHR24351:SF48","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10436|UniProtKB=P23443","P06959; P00032; P04397; P04393; P00047; P00048"]
["p70 S6 kinase - phospho","Thr389","RPS6KB1","85, 70","ms",null,7,2,"n/a","n/a","n/a","n/a","# 1214",".AML., .AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DEV., .DRR., .EGFR., .HIF., .IIR., .IMUR., .INS., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .RAS., .RTK., .SREME., .ST., .TGFB., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p53 pathway by glucose deprivation; Ras Pathway; PDGF signaling pathway; PI3 kinase pathway","RIBOSOMAL PROTEIN S6 KINASE BETA-1","aging; apoptotic process; behavioral fear response; cell cycle; cell migration; cellular response to dexamethasone stimulus; cellular response to growth factor stimulus; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to organic cyclic compound; cellular response to type II interferon; G1/S transition of mitotic cell cycle; germ cell development; long-chain fatty acid import into cell; long-term memory; modulation of chemical synaptic transmission; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of mitotic cell cycle; positive regulation of skeletal muscle tissue growth; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of translation; positive regulation of translational initiation; protein kinase B signaling; protein phosphorylation; regulation of glucose import; regulation of translation; response to amino acid; response to electrical stimulus involved in regulation of muscle adaptation; response to ethanol; response to glucagon; response to glucocorticoid; response to glucose; response to heat; response to insulin; response to leucine; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to nutrient levels; response to organic cyclic compound; response to organic substance; response to organonitrogen compound; response to peptide hormone; response to testosterone; response to toxic substance; response to tumor necrosis factor; response to wounding; response to xenobiotic stimulus; signal transduction; skeletal muscle atrophy; skeletal muscle contraction; TOR signaling","ATP binding; identical protein binding; kinase activity; nucleotide binding; PDZ domain binding; peptide binding; protein binding; protein kinase activity; protein phosphatase 2A binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cell surface; cytoplasm; cytosol; glutamatergic synapse; membrane; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynapse; synapse","Translational control","ribosomal protein S6 kinase B1","http://www.ncbi.nlm.nih.gov/gene/?term=6198","6198","72508","83840",null,"100127158",null,"P23443","Q8BSK8","P67999","A0A8I3PNG8","A0A481C7T7","A0A1D5QKR7","GO:0009986; GO:0005737; GO:0005829; GO:0098978; GO:0016020; GO:0005741; GO:0005739; GO:0043005; GO:0005654; GO:0005634; GO:0048471; GO:0098794; GO:0045202","GO:0005524; GO:0042802; GO:0016301; GO:0000166; GO:0030165; GO:0042277; GO:0005515; GO:0004672; GO:0051721; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0007568; GO:0006915; GO:0001662; GO:0007049; GO:0016477; GO:0071549; GO:0071363; GO:0032870; GO:0032869; GO:0071407; GO:0071346; GO:0000082; GO:0007281; GO:0044539; GO:0007616; GO:0050804; GO:0043066; GO:2001237; GO:0046627; GO:0018105; GO:0048015; GO:0016310; GO:0045931; GO:0048633; GO:0014911; GO:0048661; GO:0045727; GO:0045948; GO:0043491; GO:0006468; GO:0046324; GO:0006417; GO:0043200; GO:0014878; GO:0045471; GO:0033762; GO:0051384; GO:0009749; GO:0009408; GO:0032868; GO:0043201; GO:0032496; GO:0009612; GO:0007584; GO:0031667; GO:0014070; GO:0010033; GO:0010243; GO:0043434; GO:0033574; GO:0009636; GO:0034612; GO:0009611; GO:0009410; GO:0007165; GO:0014732; GO:0003009; GO:0031929","PTHR24351:SF48","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10436|UniProtKB=P23443","P06959; P00032; P04397; P04393; P00047; P00048"]
["p70 S6 kinase - phospho","Thr421/Ser424","RPS6KB1","85, 70","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2094",".AML., .AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRR., .EGFR., .HIF., .IIR., .IMUR., .INS., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .RAS., .RTK., .SREME., .ST., .TGFB., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; p53 pathway by glucose deprivation; Ras Pathway; PDGF signaling pathway; PI3 kinase pathway","RIBOSOMAL PROTEIN S6 KINASE BETA-1","aging; apoptotic process; behavioral fear response; cell cycle; cell migration; cellular response to dexamethasone stimulus; cellular response to growth factor stimulus; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to organic cyclic compound; cellular response to type II interferon; G1/S transition of mitotic cell cycle; germ cell development; long-chain fatty acid import into cell; long-term memory; modulation of chemical synaptic transmission; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of mitotic cell cycle; positive regulation of skeletal muscle tissue growth; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of translation; positive regulation of translational initiation; protein kinase B signaling; protein phosphorylation; regulation of glucose import; regulation of translation; response to amino acid; response to electrical stimulus involved in regulation of muscle adaptation; response to ethanol; response to glucagon; response to glucocorticoid; response to glucose; response to heat; response to insulin; response to leucine; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to nutrient levels; response to organic cyclic compound; response to organic substance; response to organonitrogen compound; response to peptide hormone; response to testosterone; response to toxic substance; response to tumor necrosis factor; response to wounding; response to xenobiotic stimulus; signal transduction; skeletal muscle atrophy; skeletal muscle contraction; TOR signaling","ATP binding; identical protein binding; kinase activity; nucleotide binding; PDZ domain binding; peptide binding; protein binding; protein kinase activity; protein phosphatase 2A binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cell surface; cytoplasm; cytosol; glutamatergic synapse; membrane; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynapse; synapse","Translational control","ribosomal protein S6 kinase B1","http://www.ncbi.nlm.nih.gov/gene/?term=6198","6198","72508","83840",null,"100127158",null,"P23443","Q8BSK8","P67999","A0A8I3PNG8","A0A481C7T7","A0A1D5QKR7","GO:0009986; GO:0005737; GO:0005829; GO:0098978; GO:0016020; GO:0005741; GO:0005739; GO:0043005; GO:0005654; GO:0005634; GO:0048471; GO:0098794; GO:0045202","GO:0005524; GO:0042802; GO:0016301; GO:0000166; GO:0030165; GO:0042277; GO:0005515; GO:0004672; GO:0051721; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0007568; GO:0006915; GO:0001662; GO:0007049; GO:0016477; GO:0071549; GO:0071363; GO:0032870; GO:0032869; GO:0071407; GO:0071346; GO:0000082; GO:0007281; GO:0044539; GO:0007616; GO:0050804; GO:0043066; GO:2001237; GO:0046627; GO:0018105; GO:0048015; GO:0016310; GO:0045931; GO:0048633; GO:0014911; GO:0048661; GO:0045727; GO:0045948; GO:0043491; GO:0006468; GO:0046324; GO:0006417; GO:0043200; GO:0014878; GO:0045471; GO:0033762; GO:0051384; GO:0009749; GO:0009408; GO:0032868; GO:0043201; GO:0032496; GO:0009612; GO:0007584; GO:0031667; GO:0014070; GO:0010033; GO:0010243; GO:0043434; GO:0033574; GO:0009636; GO:0034612; GO:0009611; GO:0009410; GO:0007165; GO:0014732; GO:0003009; GO:0031929","PTHR24351:SF48","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10436|UniProtKB=P23443","P06959; P00032; P04397; P04393; P00047; P00048"]
["p73",null,"TP73","80, 68","ms",null,6,2,2,1,2,2,"# 0323",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .DI., .DREP., .DRR., .HIPPO., .HUNT., .MAPK., .OP., .OT., .P53S., .RTK., .TRASR.","p53 pathway; p53 pathway by glucose deprivation; P53 pathway feedback loops 1; Huntington disease; p53 pathway feedback loops 2","TUMOR PROTEIN P73","apoptotic process; cell cycle; cellular response to DNA damage stimulus; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; kidney development; mismatch repair; negative regulation of cardiac muscle cell proliferation; negative regulation of neuron differentiation; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of lung ciliated cell differentiation; positive regulation of MAPK cascade; positive regulation of oligodendrocyte differentiation; positive regulation of transcription by RNA polymerase II; protein tetramerization; regulation of cell cycle; regulation of DNA-templated transcription; regulation of gene expression; regulation of mitotic cell cycle; regulation of transcription by RNA polymerase II; response to organonitrogen compound; response to xenobiotic stimulus","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; p53 binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding","cell junction; chromatin; cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; nucleus",null,"tumor protein p73","http://www.ncbi.nlm.nih.gov/gene/?term=7161","7161","22062",null,null,null,null,"O15350","Q9JJP2","A0A8I5ZJF2","A0A8P0P2Z4","A0A5G2QFG5","F6VXD2","GO:0030054; GO:0000785; GO:0005737; GO:0005829; GO:0005794; GO:0043231; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0042802; GO:0097371; GO:0046872; GO:0002039; GO:0005515; GO:0019901; GO:0000978; GO:0061629; GO:0043565; GO:0000976","GO:0006915; GO:0007049; GO:0006974; GO:0008630; GO:0042771; GO:0001822; GO:0006298; GO:0060044; GO:0045665; GO:0043065; GO:0045893; GO:1901248; GO:0043410; GO:0048714; GO:0045944; GO:0051262; GO:0051726; GO:0006355; GO:0010468; GO:0007346; GO:0006357; GO:0010243; GO:0009410","PTHR11447:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12003|UniProtKB=O15350","P00059; P04397; P04392; P00029; P04398"]
["p95 (NBS1) - phospho","Ser343","NBN","95","rb",null,2,7,"n/a","n/a","n/a","n/a","# 1366",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .OP., .OPA., .P53S., .ST.",null,"NIBRIN","blastocyst growth; cell cycle; cellular response to DNA damage stimulus; DNA damage checkpoint signaling; DNA damage response, signal transduction by p53 class mediator; DNA double-strand break processing; DNA duplex unwinding; DNA repair; DNA strand resection involved in replication fork processing; double-strand break repair; double-strand break repair via homologous recombination; homologous recombination; in utero embryonic development; intrinsic apoptotic signaling pathway; isotype switching; meiotic cell cycle; mitotic G2 DNA damage checkpoint signaling; mitotic G2/M transition checkpoint; negative regulation of telomere capping; neuroblast proliferation; neuromuscular process controlling balance; positive regulation of kinase activity; positive regulation of protein autophosphorylation; positive regulation of telomere maintenance; regulation of cell cycle; regulation of DNA-templated DNA replication initiation; t-circle formation; telomere maintenance; telomere maintenance via telomere trimming; telomeric 3' overhang formation","damaged DNA binding; DNA-binding transcription factor binding; protein binding; protein N-terminus binding","BRCA1-C complex; chromosomal region; chromosome; chromosome, telomeric region; cytosol; Mre11 complex; nuclear inclusion body; nucleolus; nucleoplasm; nucleus; PML body; replication fork; site of double-strand break","DNA damage","nibrin","http://www.ncbi.nlm.nih.gov/gene/?term=4683","4683","27354",null,null,null,null,"O60934","Q9R207","A0A8I6AGS6","A0A8I3PAJ3","A0A287AXZ9","A0A5F8ADW6","GO:0070533; GO:0098687; GO:0005694; GO:0000781; GO:0005829; GO:0030870; GO:0042405; GO:0005730; GO:0005654; GO:0005634; GO:0016605; GO:0005657; GO:0035861","GO:0003684; GO:0140297; GO:0005515; GO:0047485","GO:0001832; GO:0007049; GO:0006974; GO:0000077; GO:0030330; GO:0000729; GO:0032508; GO:0006281; GO:0110025; GO:0006302; GO:0000724; GO:0035825; GO:0001701; GO:0097193; GO:0045190; GO:0051321; GO:0007095; GO:0044818; GO:1904354; GO:0007405; GO:0050885; GO:0033674; GO:0031954; GO:0032206; GO:0051726; GO:0030174; GO:0090656; GO:0000723; GO:0090737; GO:0031860","PTHR12162:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7652|UniProtKB=O60934"]
["PAI-1",null,"SERPINE1","48","rb",null,2,2,2,2,2,6,"# 1458",".ANG., .APO., .CANCER., .CCKR., .CD., .CSP., .DEV., .HIF., .HIPPO., .IMFR., .IMUR., .LMIG., .MIG., .OP., .OPA., .OT., .P53S., .PLAT., .SREME., .ST., .TRASR.","CCKR signaling map; p53 pathway; Plasminogen activating cascade; Blood coagulation","PLASMINOGEN ACTIVATOR INHIBITOR 1","angiogenesis; cellular response to lipopolysaccharide; defense response to Gram-negative bacterium; dentinogenesis; fibrinolysis; negative regulation of blood coagulation; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; negative regulation of endopeptidase activity; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of fibrinolysis; negative regulation of peptidase activity; negative regulation of plasminogen activation; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell-matrix adhesion; negative regulation of vascular wound healing; negative regulation of wound healing; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of inflammatory response; positive regulation of interleukin-8 production; positive regulation of leukotriene production involved in inflammatory response; positive regulation of monocyte chemotaxis; positive regulation of odontoblast differentiation; positive regulation of receptor-mediated endocytosis; regulation of signaling receptor activity; replicative senescence","peptidase inhibitor activity; protease binding; protein binding; serine-type endopeptidase inhibitor activity; signaling receptor binding","collagen-containing extracellular matrix; extracellular exosome; extracellular region; extracellular space; peptidase inhibitor complex; plasma membrane; platelet alpha granule lumen; serine protease inhibitor complex","Adhesion","serpin family E member 1","http://www.ncbi.nlm.nih.gov/gene/?term=5054","5054","18787",null,"403476",null,null,"P05121","G5E899","F1LM16","A0A8I3MDS4","I3LQQ6","A0A5F7ZRT6","GO:0062023; GO:0070062; GO:0005576; GO:0005615; GO:1904090; GO:0005886; GO:0031093; GO:0097180","GO:0030414; GO:0002020; GO:0005515; GO:0004867; GO:0005102","GO:0001525; GO:0071222; GO:0050829; GO:0097187; GO:0042730; GO:0030195; GO:0033629; GO:0030336; GO:0010951; GO:2000352; GO:1902042; GO:0051918; GO:0010466; GO:0010757; GO:0014912; GO:2000098; GO:0061044; GO:0061045; GO:0045766; GO:0030194; GO:0050729; GO:0032757; GO:0035491; GO:0090026; GO:1901331; GO:0048260; GO:0010469; GO:0090399","PTHR11461:SF49","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8583|UniProtKB=P05121","P06959; P00059; P00050; P00011"]
["PAK 1/2 - phospho","Ser144/Ser141","PAK1, PAK2","74-68, 67-61","rb",null,2,2,"n/a","n/a","n/a","n/a","TK # 027",".ANG., .APO., .cAMP., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .EGFR., .GPCR., .HIPPO., .IMUF., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .RAS., .RCC., .RTK., .ST., .TCR., .VEGFS.","CCKR signaling map; T cell activation; Ras Pathway; Cytoskeletal regulation by Rho GTPase; Angiogenesis; Axon guidance mediated by semaphorins; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE PAK 1; SERINE/THREONINE-PROTEIN KINASE PAK 2","actin cytoskeleton reorganization; apoptotic process; branching morphogenesis of an epithelial tube; cell migration; cellular component organization; cellular response to DNA damage stimulus; chromatin remodeling; ephrin receptor signaling pathway; exocytosis; Fc-gamma receptor signaling pathway involved in phagocytosis; hepatocyte growth factor receptor signaling pathway; intracellular signal transduction; localization; MAPK cascade; metabolic process; negative regulation of cell proliferation involved in contact inhibition; neuron projection morphogenesis; phosphorylation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of JUN kinase activity; positive regulation of microtubule nucleation; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of axonogenesis; regulation of MAPK cascade; stimulatory C-type lectin receptor signaling pathway; wound healing; adherens junction assembly; bicellular tight junction assembly; cardiac muscle hypertrophy; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; dendritic spine development; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; negative regulation of protein kinase activity; negative regulation of stress fiber assembly; peptidyl-serine phosphorylation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; protein localization to cell-cell junction; regulation of cytoskeleton organization; signal transduction; vascular endothelial growth factor receptor signaling pathway","ATP binding; catalytic activity; collagen binding; gamma-tubulin binding; kinase activity; molecular adaptor activity; molecular function inhibitor activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity; cadherin binding; identical protein binding; protein kinase binding; protein tyrosine kinase activator activity","actin filament; anchoring junction; axon; cell projection; cell-cell junction; chromosome; cytoplasm; cytoskeleton; cytosol; dendrite; focal adhesion; intercalated disc; lamellipodium; membrane; microtubule organizing center; nuclear membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ruffle; ruffle membrane; Z disc; glutamatergic synapse; perinuclear region of cytoplasm; postsynaptic density; secretory granule","Cytoskeletal signaling","p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5058, http://www.ncbi.nlm.nih.gov/gene/?term=5062","5058, 5062","NA, 224105","29431, 29432",null,null,"NA, 710314","Q13153, Q13177","A0A0U1RQ87, Q8CIN4","P35465, Q64303","A0A8I3NAT1, A0A8I3Q5W6","A0A286ZYT3, A0A5G2R246","A0A1D5RKP7, F7GWI2","GO:0005884; GO:0070161; GO:0030424; GO:0042995; GO:0005911; GO:0005694; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0005925; GO:0014704; GO:0030027; GO:0016020; GO:0005815; GO:0031965; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0001726; GO:0032587; GO:0030018; GO:0098978; GO:0048471; GO:0014069; GO:0030141","GO:0005524; GO:0003824; GO:0005518; GO:0043015; GO:0016301; GO:0060090; GO:0140678; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0031267; GO:0016740; GO:0045296; GO:0042802; GO:0019901; GO:0030296","GO:0031532; GO:0006915; GO:0048754; GO:0016477; GO:0016043; GO:0006974; GO:0006338; GO:0048013; GO:0006887; GO:0038096; GO:0048012; GO:0035556; GO:0051179; GO:0000165; GO:0008152; GO:0060244; GO:0048812; GO:0016310; GO:0030335; GO:0008284; GO:0033148; GO:0043507; GO:0090063; GO:0031116; GO:0033138; GO:0001934; GO:0051496; GO:0046777; GO:0006468; GO:0032956; GO:0050770; GO:0043408; GO:0002223; GO:0042060; GO:0034333; GO:0070830; GO:0003300; GO:0071407; GO:0071560; GO:0060996; GO:0043066; GO:2001271; GO:0006469; GO:0051497; GO:0018105; GO:2001238; GO:0050731; GO:0150105; GO:0051493; GO:0007165; GO:0048010","PTHR48015:SF20; PTHR48015:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8590|UniProtKB=Q13153; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8591|UniProtKB=Q13177","P06959; P00053; P04393; P00016; P00005; P00007; P00031"]
["PAK 1/2/3",null,"PAK1, PAK2, PAK3","68, 61","rb",null,2,7,8,1,6,2.1,"TK # 016",".ANG., .APO., .cAMP., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .EGFR., .GPCR., .HIPPO., .IMUF., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .RAS., .RCC., .RTK., .ST., .TCR., .VEGFS.","CCKR signaling map; T cell activation; Ras Pathway; Cytoskeletal regulation by Rho GTPase; Angiogenesis; Axon guidance mediated by semaphorins; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE PAK 1; SERINE/THREONINE-PROTEIN KINASE PAK 2; SERINE/THREONINE-PROTEIN KINASE PAK 3","actin cytoskeleton reorganization; apoptotic process; branching morphogenesis of an epithelial tube; cell migration; cellular component organization; cellular response to DNA damage stimulus; chromatin remodeling; ephrin receptor signaling pathway; exocytosis; Fc-gamma receptor signaling pathway involved in phagocytosis; hepatocyte growth factor receptor signaling pathway; intracellular signal transduction; localization; MAPK cascade; metabolic process; negative regulation of cell proliferation involved in contact inhibition; neuron projection morphogenesis; phosphorylation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of JUN kinase activity; positive regulation of microtubule nucleation; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of axonogenesis; regulation of MAPK cascade; stimulatory C-type lectin receptor signaling pathway; wound healing; adherens junction assembly; bicellular tight junction assembly; cardiac muscle hypertrophy; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; dendritic spine development; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; negative regulation of protein kinase activity; negative regulation of stress fiber assembly; peptidyl-serine phosphorylation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; protein localization to cell-cell junction; regulation of cytoskeleton organization; signal transduction; vascular endothelial growth factor receptor signaling pathway; axonogenesis; dendrite development; dendritic spine morphogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of DNA biosynthetic process; positive regulation of fibroblast migration; positive regulation of neuron apoptotic process; regulation of actin filament polymerization; regulation of neuron projection development; regulation of postsynapse organization; synapse organization","ATP binding; catalytic activity; collagen binding; gamma-tubulin binding; kinase activity; molecular adaptor activity; molecular function inhibitor activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity; cadherin binding; identical protein binding; protein kinase binding; protein tyrosine kinase activator activity; GTPase binding; MAP kinase kinase activity; metal ion binding; SH3 domain binding","actin filament; anchoring junction; axon; cell projection; cell-cell junction; chromosome; cytoplasm; cytoskeleton; cytosol; dendrite; focal adhesion; intercalated disc; lamellipodium; membrane; microtubule organizing center; nuclear membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ruffle; ruffle membrane; Z disc; glutamatergic synapse; perinuclear region of cytoplasm; postsynaptic density; secretory granule; endosome","Cytoskeletal signaling","p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 (RAC1) activated kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=5058, http://www.ncbi.nlm.nih.gov/gene/?term=5062, http://www.ncbi.nlm.nih.gov/gene/?term=5063","5058, 5062, 5063","NA, 224105, 18481","29431, 29432, 29433","NA, 492067",null,"NA, 710314, 706217","Q13153, Q13177, O75914","A0A0U1RQ87, Q8CIN4, Q61036","P35465, Q64303, Q62829","A0A8I3NAT1, A0A8I3Q5W6, A0A8P0NUY8","A0A286ZYT3, A0A5G2R246","A0A1D5RKP7, F7GWI2, A0A1D5Q7U4","GO:0005884; GO:0070161; GO:0030424; GO:0042995; GO:0005911; GO:0005694; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0005925; GO:0014704; GO:0030027; GO:0016020; GO:0005815; GO:0031965; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0001726; GO:0032587; GO:0030018; GO:0098978; GO:0048471; GO:0014069; GO:0030141; GO:0005768","GO:0005524; GO:0003824; GO:0005518; GO:0043015; GO:0016301; GO:0060090; GO:0140678; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0031267; GO:0016740; GO:0045296; GO:0042802; GO:0019901; GO:0030296; GO:0051020; GO:0004708; GO:0046872; GO:0017124","GO:0031532; GO:0006915; GO:0048754; GO:0016477; GO:0016043; GO:0006974; GO:0006338; GO:0048013; GO:0006887; GO:0038096; GO:0048012; GO:0035556; GO:0051179; GO:0000165; GO:0008152; GO:0060244; GO:0048812; GO:0016310; GO:0030335; GO:0008284; GO:0033148; GO:0043507; GO:0090063; GO:0031116; GO:0033138; GO:0001934; GO:0051496; GO:0046777; GO:0006468; GO:0032956; GO:0050770; GO:0043408; GO:0002223; GO:0042060; GO:0034333; GO:0070830; GO:0003300; GO:0071407; GO:0071560; GO:0060996; GO:0043066; GO:2001271; GO:0006469; GO:0051497; GO:0018105; GO:2001238; GO:0050731; GO:0150105; GO:0051493; GO:0007165; GO:0048010; GO:0007409; GO:0016358; GO:0060997; GO:0061003; GO:2000573; GO:0010763; GO:0043525; GO:0030833; GO:0010975; GO:0099175; GO:0050808","PTHR48015:SF20; PTHR48015:SF22; PTHR48015:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8590|UniProtKB=Q13153; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8591|UniProtKB=Q13177; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8592|UniProtKB=O75914","P06959; P00053; P04393; P00016; P00005; P00007; P00031"]
["PAK 1/2/3 - phospho","Ser141","PAK1, PAK2, PAK3","74-68, 67-61","rb",null,2,2,2,2,2,2,"TK # 061",".ANG., .APO., .cAMP., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .EGFR., .GPCR., .HIPPO., .IMUF., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .RAS., .RCC., .RTK., .ST., .TCR., .VEGFS.","CCKR signaling map; T cell activation; Ras Pathway; Cytoskeletal regulation by Rho GTPase; Angiogenesis; Axon guidance mediated by semaphorins; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE PAK 1; SERINE/THREONINE-PROTEIN KINASE PAK 2; SERINE/THREONINE-PROTEIN KINASE PAK 3","actin cytoskeleton reorganization; apoptotic process; branching morphogenesis of an epithelial tube; cell migration; cellular component organization; cellular response to DNA damage stimulus; chromatin remodeling; ephrin receptor signaling pathway; exocytosis; Fc-gamma receptor signaling pathway involved in phagocytosis; hepatocyte growth factor receptor signaling pathway; intracellular signal transduction; localization; MAPK cascade; metabolic process; negative regulation of cell proliferation involved in contact inhibition; neuron projection morphogenesis; phosphorylation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of JUN kinase activity; positive regulation of microtubule nucleation; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of axonogenesis; regulation of MAPK cascade; stimulatory C-type lectin receptor signaling pathway; wound healing; adherens junction assembly; bicellular tight junction assembly; cardiac muscle hypertrophy; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; dendritic spine development; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; negative regulation of protein kinase activity; negative regulation of stress fiber assembly; peptidyl-serine phosphorylation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; protein localization to cell-cell junction; regulation of cytoskeleton organization; signal transduction; vascular endothelial growth factor receptor signaling pathway; axonogenesis; dendrite development; dendritic spine morphogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of DNA biosynthetic process; positive regulation of fibroblast migration; positive regulation of neuron apoptotic process; regulation of actin filament polymerization; regulation of neuron projection development; regulation of postsynapse organization; synapse organization","ATP binding; catalytic activity; collagen binding; gamma-tubulin binding; kinase activity; molecular adaptor activity; molecular function inhibitor activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity; cadherin binding; identical protein binding; protein kinase binding; protein tyrosine kinase activator activity; GTPase binding; MAP kinase kinase activity; metal ion binding; SH3 domain binding","actin filament; anchoring junction; axon; cell projection; cell-cell junction; chromosome; cytoplasm; cytoskeleton; cytosol; dendrite; focal adhesion; intercalated disc; lamellipodium; membrane; microtubule organizing center; nuclear membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ruffle; ruffle membrane; Z disc; glutamatergic synapse; perinuclear region of cytoplasm; postsynaptic density; secretory granule; endosome","Cytoskeletal signaling","p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 (RAC1) activated kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=5058, http://www.ncbi.nlm.nih.gov/gene/?term=5062, http://www.ncbi.nlm.nih.gov/gene/?term=5063","5058, 5062, 5063","NA, 224105, 18481","29431, 29432, 29433","NA, 492067",null,"NA, 710314, 706217","Q13153, Q13177, O75914","A0A0U1RQ87, Q8CIN4, Q61036","P35465, Q64303, Q62829","A0A8I3NAT1, A0A8I3Q5W6, A0A8P0NUY8","A0A286ZYT3, A0A5G2R246","A0A1D5RKP7, F7GWI2, A0A1D5Q7U4","GO:0005884; GO:0070161; GO:0030424; GO:0042995; GO:0005911; GO:0005694; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0005925; GO:0014704; GO:0030027; GO:0016020; GO:0005815; GO:0031965; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0001726; GO:0032587; GO:0030018; GO:0098978; GO:0048471; GO:0014069; GO:0030141; GO:0005768","GO:0005524; GO:0003824; GO:0005518; GO:0043015; GO:0016301; GO:0060090; GO:0140678; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0031267; GO:0016740; GO:0045296; GO:0042802; GO:0019901; GO:0030296; GO:0051020; GO:0004708; GO:0046872; GO:0017124","GO:0031532; GO:0006915; GO:0048754; GO:0016477; GO:0016043; GO:0006974; GO:0006338; GO:0048013; GO:0006887; GO:0038096; GO:0048012; GO:0035556; GO:0051179; GO:0000165; GO:0008152; GO:0060244; GO:0048812; GO:0016310; GO:0030335; GO:0008284; GO:0033148; GO:0043507; GO:0090063; GO:0031116; GO:0033138; GO:0001934; GO:0051496; GO:0046777; GO:0006468; GO:0032956; GO:0050770; GO:0043408; GO:0002223; GO:0042060; GO:0034333; GO:0070830; GO:0003300; GO:0071407; GO:0071560; GO:0060996; GO:0043066; GO:2001271; GO:0006469; GO:0051497; GO:0018105; GO:2001238; GO:0050731; GO:0150105; GO:0051493; GO:0007165; GO:0048010; GO:0007409; GO:0016358; GO:0060997; GO:0061003; GO:2000573; GO:0010763; GO:0043525; GO:0030833; GO:0010975; GO:0099175; GO:0050808","PTHR48015:SF20; PTHR48015:SF22; PTHR48015:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8590|UniProtKB=Q13153; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8591|UniProtKB=Q13177; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8592|UniProtKB=O75914","P06959; P00053; P04393; P00016; P00005; P00007; P00031"]
["PAK 1/2/3 - phospho","Thr423/Thr402/Thr436","PAK1, PAK2, PAK3","70-68","rb",null,4,4,"n/a","n/a","n/a","n/a","TK # 106",".ANG., .APO., .cAMP., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .EGFR., .GPCR., .HIPPO., .IMUF., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .RAS., .RCC., .RTK., .ST., .TCR., .VEGFS.","CCKR signaling map; T cell activation; Ras Pathway; Cytoskeletal regulation by Rho GTPase; Angiogenesis; Axon guidance mediated by semaphorins; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE PAK 1; SERINE/THREONINE-PROTEIN KINASE PAK 2; SERINE/THREONINE-PROTEIN KINASE PAK 3","actin cytoskeleton reorganization; apoptotic process; branching morphogenesis of an epithelial tube; cell migration; cellular component organization; cellular response to DNA damage stimulus; chromatin remodeling; ephrin receptor signaling pathway; exocytosis; Fc-gamma receptor signaling pathway involved in phagocytosis; hepatocyte growth factor receptor signaling pathway; intracellular signal transduction; localization; MAPK cascade; metabolic process; negative regulation of cell proliferation involved in contact inhibition; neuron projection morphogenesis; phosphorylation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of JUN kinase activity; positive regulation of microtubule nucleation; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of axonogenesis; regulation of MAPK cascade; stimulatory C-type lectin receptor signaling pathway; wound healing; adherens junction assembly; bicellular tight junction assembly; cardiac muscle hypertrophy; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; dendritic spine development; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; negative regulation of protein kinase activity; negative regulation of stress fiber assembly; peptidyl-serine phosphorylation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; protein localization to cell-cell junction; regulation of cytoskeleton organization; signal transduction; vascular endothelial growth factor receptor signaling pathway; axonogenesis; dendrite development; dendritic spine morphogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of DNA biosynthetic process; positive regulation of fibroblast migration; positive regulation of neuron apoptotic process; regulation of actin filament polymerization; regulation of neuron projection development; regulation of postsynapse organization; synapse organization","ATP binding; catalytic activity; collagen binding; gamma-tubulin binding; kinase activity; molecular adaptor activity; molecular function inhibitor activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity; cadherin binding; identical protein binding; protein kinase binding; protein tyrosine kinase activator activity; GTPase binding; MAP kinase kinase activity; metal ion binding; SH3 domain binding","actin filament; anchoring junction; axon; cell projection; cell-cell junction; chromosome; cytoplasm; cytoskeleton; cytosol; dendrite; focal adhesion; intercalated disc; lamellipodium; membrane; microtubule organizing center; nuclear membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ruffle; ruffle membrane; Z disc; glutamatergic synapse; perinuclear region of cytoplasm; postsynaptic density; secretory granule; endosome","Cytoskeletal signaling","p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 (RAC1) activated kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=5058, http://www.ncbi.nlm.nih.gov/gene/?term=5062, http://www.ncbi.nlm.nih.gov/gene/?term=5063","5058, 5062, 5063","NA, 224105, 18481","29431, 29432, 29433","NA, 492067",null,"NA, 710314, 706217","Q13153, Q13177, O75914","A0A0U1RQ87, Q8CIN4, Q61036","P35465, Q64303, Q62829","A0A8I3NAT1, A0A8I3Q5W6, A0A8P0NUY8","A0A286ZYT3, A0A5G2R246","A0A1D5RKP7, F7GWI2, A0A1D5Q7U4","GO:0005884; GO:0070161; GO:0030424; GO:0042995; GO:0005911; GO:0005694; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0005925; GO:0014704; GO:0030027; GO:0016020; GO:0005815; GO:0031965; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0001726; GO:0032587; GO:0030018; GO:0098978; GO:0048471; GO:0014069; GO:0030141; GO:0005768","GO:0005524; GO:0003824; GO:0005518; GO:0043015; GO:0016301; GO:0060090; GO:0140678; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0031267; GO:0016740; GO:0045296; GO:0042802; GO:0019901; GO:0030296; GO:0051020; GO:0004708; GO:0046872; GO:0017124","GO:0031532; GO:0006915; GO:0048754; GO:0016477; GO:0016043; GO:0006974; GO:0006338; GO:0048013; GO:0006887; GO:0038096; GO:0048012; GO:0035556; GO:0051179; GO:0000165; GO:0008152; GO:0060244; GO:0048812; GO:0016310; GO:0030335; GO:0008284; GO:0033148; GO:0043507; GO:0090063; GO:0031116; GO:0033138; GO:0001934; GO:0051496; GO:0046777; GO:0006468; GO:0032956; GO:0050770; GO:0043408; GO:0002223; GO:0042060; GO:0034333; GO:0070830; GO:0003300; GO:0071407; GO:0071560; GO:0060996; GO:0043066; GO:2001271; GO:0006469; GO:0051497; GO:0018105; GO:2001238; GO:0050731; GO:0150105; GO:0051493; GO:0007165; GO:0048010; GO:0007409; GO:0016358; GO:0060997; GO:0061003; GO:2000573; GO:0010763; GO:0043525; GO:0030833; GO:0010975; GO:0099175; GO:0050808","PTHR48015:SF20; PTHR48015:SF22; PTHR48015:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8590|UniProtKB=Q13153; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8591|UniProtKB=Q13177; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8592|UniProtKB=O75914","P06959; P00053; P04393; P00016; P00005; P00007; P00031"]
["PAK 2",null,"PAK2","61","rb",null,1,1,8,6,1,8,"# 2067",".ANG., .APO., .CANCER., .CD., .CSP., .EGFR., .IMUF., .INFM., .MAPK., .OP., .OPA., .RAS., .RCC., .RTK., .ST., .TCR., .VEGFS.","T cell activation; Ras Pathway; Cytoskeletal regulation by Rho GTPase; Angiogenesis; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE PAK 2","adherens junction assembly; apoptotic process; bicellular tight junction assembly; cardiac muscle hypertrophy; cellular component organization; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; dendritic spine development; intracellular signal transduction; localization; metabolic process; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; negative regulation of protein kinase activity; negative regulation of stress fiber assembly; peptidyl-serine phosphorylation; phosphorylation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; protein autophosphorylation; protein localization to cell-cell junction; protein phosphorylation; regulation of axonogenesis; regulation of cytoskeleton organization; regulation of MAPK cascade; signal transduction; stimulatory C-type lectin receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway","ATP binding; cadherin binding; catalytic activity; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activator activity; small GTPase binding; transferase activity","cell-cell junction; cytoplasm; cytosol; glutamatergic synapse; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; secretory granule","Cytoskeletal signaling","p21 (RAC1) activated kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5062","5062","224105","29432",null,null,"710314","Q13177","Q8CIN4","Q64303","A0A8I3Q5W6","A0A5G2R246","F7GWI2","GO:0005911; GO:0005737; GO:0005829; GO:0098978; GO:0016020; GO:0005634; GO:0048471; GO:0005886; GO:0014069; GO:0030141","GO:0005524; GO:0045296; GO:0003824; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0030296; GO:0031267; GO:0016740","GO:0034333; GO:0006915; GO:0070830; GO:0003300; GO:0016043; GO:0071407; GO:0071560; GO:0060996; GO:0035556; GO:0051179; GO:0008152; GO:0043066; GO:2001271; GO:0006469; GO:0051497; GO:0018105; GO:0016310; GO:2001238; GO:0050731; GO:0046777; GO:0150105; GO:0006468; GO:0050770; GO:0051493; GO:0043408; GO:0007165; GO:0002223; GO:0048010","PTHR48015:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8591|UniProtKB=Q13177","P00053; P04393; P00016; P00005; P00031"]
["PAK 4",null,"PAK4","72","rb",null,2,8,"n/a","n/a","n/a","n/a","# 2839",".ANG., .APO., .CANCER., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .IMUF., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .RAS., .RCC., .RTK., .ST., .TCR.","Cytoskeletal regulation by Rho GTPase; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE PAK 4","apoptotic process; cell cycle; cell migration; cell-cell adhesion; cellular component organization; cellular response to organic cyclic compound; cytoskeleton organization; dendritic spine development; intracellular signal transduction; negative regulation of endothelial cell apoptotic process; phosphorylation; positive regulation of angiogenesis; protein phosphorylation; regulation of cell growth; regulation of MAPK cascade; signal transduction","ATP binding; cadherin binding involved in cell-cell adhesion; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","adherens junction; cytoplasm; cytosol; focal adhesion; Golgi apparatus","Cytoskeletal signaling","p21 (RAC1) activated kinase 4","http://www.ncbi.nlm.nih.gov/gene/?term=10298","10298","70584","292756","484513","100627936",null,"O96013","Q8BTW9","B5DF62","A0A8I3MU75","A0A480YBA9","A0A1D5QPF3","GO:0005912; GO:0005737; GO:0005829; GO:0005925; GO:0005794","GO:0005524; GO:0098641; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0006915; GO:0007049; GO:0016477; GO:0098609; GO:0016043; GO:0071407; GO:0007010; GO:0060996; GO:0035556; GO:2000352; GO:0016310; GO:0045766; GO:0006468; GO:0001558; GO:0043408; GO:0007165","PTHR48015:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16059|UniProtKB=O96013","P00016; P00031"]
["PAK 4/5/6 - phospho","Ser474/Ser602/Ser560","PAK4, PAK6, PAK5","90, 82, 72","rb",null,2,1,8,8,8,8,"# 3029",".ANG., .APO., .CANCER., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .IMUF., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .RAS., .RCC., .RTK., .ST., .TCR., .TRASR.","Cytoskeletal regulation by Rho GTPase; Inflammation mediated by chemokine and cytokine signaling pathway","SERINE/THREONINE-PROTEIN KINASE PAK 4; SERINE/THREONINE-PROTEIN KINASE PAK 6; SERINE/THREONINE-PROTEIN KINASE PAK 5","apoptotic process; cell cycle; cell migration; cell-cell adhesion; cellular component organization; cellular response to organic cyclic compound; cytoskeleton organization; dendritic spine development; intracellular signal transduction; negative regulation of endothelial cell apoptotic process; phosphorylation; positive regulation of angiogenesis; protein phosphorylation; regulation of cell growth; regulation of MAPK cascade; signal transduction; learning; locomotory behavior; memory; neuron projection arborization; neuron projection extension; regulation of DNA-templated transcription; cell population proliferation; negative regulation of extrinsic apoptotic signaling pathway","ATP binding; cadherin binding involved in cell-cell adhesion; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; cadherin binding","adherens junction; cytoplasm; cytosol; focal adhesion; Golgi apparatus; cell junction; fibrillar center; nucleoplasm; nucleus; postsynaptic density; mitochondrion; plasma membrane; synapse","Cytoskeletal signaling","p21 (RAC1) activated kinase 4; p21 (RAC1) activated kinase 6; p21 (RAC1) activated kinase 5","http://www.ncbi.nlm.nih.gov/gene/?term=10298, http://www.ncbi.nlm.nih.gov/gene/?term=106821730, http://www.ncbi.nlm.nih.gov/gene/?term=57144","10298, 106821730, 57144","70584, 214230, 241656","292756, 296078, 311450","484513, NA, 485772","100627936, NA","NA, 701589","O96013, Q9NQU5, Q9P286","Q8BTW9, Q3ULB5, Q8C015","B5DF62, D3ZQ51, D4A280","A0A8I3MU75, A0A8P0NW23, A0A8I3PJQ0","A0A480YBA9, A0A286ZJP1, A0A286ZXD7","A0A1D5QPF3, F6TWF0, A0A5F8AT53","GO:0005912; GO:0005737; GO:0005829; GO:0005925; GO:0005794; GO:0030054; GO:0001650; GO:0005654; GO:0005634; GO:0014069; GO:0005739; GO:0005886; GO:0045202","GO:0005524; GO:0098641; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740; GO:0045296","GO:0006915; GO:0007049; GO:0016477; GO:0098609; GO:0016043; GO:0071407; GO:0007010; GO:0060996; GO:0035556; GO:2000352; GO:0016310; GO:0045766; GO:0006468; GO:0001558; GO:0043408; GO:0007165; GO:0007612; GO:0007626; GO:0007613; GO:0140058; GO:1990138; GO:0006355; GO:0008283; GO:2001237","PTHR48015:SF17; PTHR48015:SF19; PTHR48015:SF27","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16059|UniProtKB=O96013; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16061|UniProtKB=Q9NQU5; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=15916|UniProtKB=Q9P286","P00016; P00031"]
["PARP",null,"PARP1","116, 89","rb",null,2,2.1,1.1000000000000001,8,5,5,"# 1914",".APO., .CD., .CSP., .DDR., .DEV., .DREP., .FAS., .IIR., .IMU., .IMUF., .IMUR., .INS., .NFKB., .OP., .OPA., .OT., .OXS., .SREME., .ST., .TGFB., .TRASR.","FAS signaling pathway","POLY [ADP-RIBOSE] POLYMERASE 1","apoptotic process; ATP generation from poly-ADP-D-ribose; carbohydrate biosynthetic process; cellular response to amyloid-beta; cellular response to DNA damage stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidative stress; cellular response to transforming growth factor beta stimulus; cellular response to UV; cellular response to zinc ion; decidualization; DNA ADP-ribosylation; DNA repair; double-strand break repair; immune system process; innate immune response; macrophage differentiation; metabolic process; mitochondrial DNA metabolic process; mitochondrial DNA repair; mitochondrion organization; negative regulation of ATP biosynthetic process; negative regulation of innate immune response; negative regulation of telomere maintenance via telomere lengthening; negative regulation of transcription by RNA polymerase II; positive regulation of cardiac muscle hypertrophy; positive regulation of double-strand break repair via homologous recombination; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of mitochondrial depolarization; positive regulation of myofibroblast differentiation; positive regulation of necroptotic process; positive regulation of neuron death; positive regulation of protein localization to nucleus; positive regulation of single strand break repair; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; protein auto-ADP-ribosylation; protein autoprocessing; protein modification process; protein poly-ADP-ribosylation; regulation of catalytic activity; regulation of circadian sleep/wake cycle, non-REM sleep; regulation of DNA metabolic process; regulation of DNA methylation; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; regulation of protein localization; regulation of SMAD protein complex assembly; replication fork reversal; response to aldosterone; response to gamma radiation; signal transduction involved in regulation of gene expression; telomere maintenance; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway","catalytic activity; damaged DNA binding; DNA binding; enzyme binding; glycosyltransferase activity; histone deacetylase binding; identical protein binding; metal ion binding; NAD binding; NAD DNA ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD+- protein-aspartate ADP-ribosyltransferase activity; NAD+-protein ADP-ribosyltransferase activity; NAD+-protein-glutamate ADP-ribosyltransferase activity; NAD+-protein-histidine ADP-ribosyltransferase activity; NAD+-protein-serine ADP-ribosyltransferase activity; NAD+-protein-tyrosine ADP-ribosyltransferase activity; nuclear estrogen receptor binding; nucleosome binding; nucleotidyltransferase activity; protein binding; protein homodimerization activity; protein kinase binding; protein N-terminus binding; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; SMAD binding; transferase activity; zinc ion binding","chromatin; chromosome; chromosome, telomeric region; cytoplasm; cytosol; membrane; mitochondrion; nuclear body; nuclear envelope; nuclear replication fork; nucleolus; nucleoplasm; nucleus; protein-containing complex; protein-DNA complex; site of DNA damage; site of double-strand break; transcription regulator complex","Apoptosis","poly(ADP-ribose) polymerase 1","http://www.ncbi.nlm.nih.gov/gene/?term=142","142",null,"25591",null,null,null,"P09874","A0A0A6YVX0","P27008","A0A8I3N694","A0A5G2R0N8","F7EMW7","GO:0000785; GO:0005694; GO:0000781; GO:0005737; GO:0005829; GO:0016020; GO:0005739; GO:0016604; GO:0005635; GO:0043596; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0032993; GO:0090734; GO:0035861; GO:0005667","GO:0003824; GO:0003684; GO:0003677; GO:0019899; GO:0016757; GO:0042826; GO:0042802; GO:0046872; GO:0051287; GO:0140294; GO:0003950; GO:0140806; GO:1990404; GO:0140807; GO:0140815; GO:0140805; GO:0140808; GO:0030331; GO:0031491; GO:0016779; GO:0005515; GO:0042803; GO:0019901; GO:0047485; GO:0003723; GO:0061629; GO:0070412; GO:0046332; GO:0016740; GO:0008270","GO:0006915; GO:1990966; GO:0016051; GO:1904646; GO:0006974; GO:0032869; GO:1990090; GO:0034599; GO:0071560; GO:0034644; GO:0071294; GO:0046697; GO:0030592; GO:0006281; GO:0006302; GO:0002376; GO:0045087; GO:0030225; GO:0008152; GO:0032042; GO:0043504; GO:0007005; GO:2001170; GO:0045824; GO:1904357; GO:0000122; GO:0010613; GO:1905168; GO:0033148; GO:0051901; GO:1904762; GO:0060545; GO:1901216; GO:1900182; GO:1903518; GO:0060391; GO:0045944; GO:2000679; GO:0070213; GO:0016540; GO:0036211; GO:0070212; GO:0050790; GO:0045188; GO:0051052; GO:0044030; GO:1903376; GO:0032880; GO:0010990; GO:0071932; GO:1904044; GO:0010332; GO:0023019; GO:0000723; GO:0006366; GO:0007179","PTHR10459:SF112","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=270|UniProtKB=P09874","P00020"]
["PARP - cleaved","Asp214","PARP1","89","rb",null,2,4,8,8,8,8,"# 1915",".APO., .CD., .CSP., .DDR., .DEV., .DREP., .FAS., .IIR., .IMU., .IMUF., .IMUR., .INS., .NFKB., .OP., .OPA., .OT., .OXS., .SREME., .ST., .TGFB., .TRASR.","FAS signaling pathway","POLY [ADP-RIBOSE] POLYMERASE 1","apoptotic process; ATP generation from poly-ADP-D-ribose; carbohydrate biosynthetic process; cellular response to amyloid-beta; cellular response to DNA damage stimulus; cellular response to insulin stimulus; cellular response to nerve growth factor stimulus; cellular response to oxidative stress; cellular response to transforming growth factor beta stimulus; cellular response to UV; cellular response to zinc ion; decidualization; DNA ADP-ribosylation; DNA repair; double-strand break repair; immune system process; innate immune response; macrophage differentiation; metabolic process; mitochondrial DNA metabolic process; mitochondrial DNA repair; mitochondrion organization; negative regulation of ATP biosynthetic process; negative regulation of innate immune response; negative regulation of telomere maintenance via telomere lengthening; negative regulation of transcription by RNA polymerase II; positive regulation of cardiac muscle hypertrophy; positive regulation of double-strand break repair via homologous recombination; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of mitochondrial depolarization; positive regulation of myofibroblast differentiation; positive regulation of necroptotic process; positive regulation of neuron death; positive regulation of protein localization to nucleus; positive regulation of single strand break repair; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; protein auto-ADP-ribosylation; protein autoprocessing; protein modification process; protein poly-ADP-ribosylation; regulation of catalytic activity; regulation of circadian sleep/wake cycle, non-REM sleep; regulation of DNA metabolic process; regulation of DNA methylation; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; regulation of protein localization; regulation of SMAD protein complex assembly; replication fork reversal; response to aldosterone; response to gamma radiation; signal transduction involved in regulation of gene expression; telomere maintenance; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway","catalytic activity; damaged DNA binding; DNA binding; enzyme binding; glycosyltransferase activity; histone deacetylase binding; identical protein binding; metal ion binding; NAD binding; NAD DNA ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD+- protein-aspartate ADP-ribosyltransferase activity; NAD+-protein ADP-ribosyltransferase activity; NAD+-protein-glutamate ADP-ribosyltransferase activity; NAD+-protein-histidine ADP-ribosyltransferase activity; NAD+-protein-serine ADP-ribosyltransferase activity; NAD+-protein-tyrosine ADP-ribosyltransferase activity; nuclear estrogen receptor binding; nucleosome binding; nucleotidyltransferase activity; protein binding; protein homodimerization activity; protein kinase binding; protein N-terminus binding; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; SMAD binding; transferase activity; zinc ion binding","chromatin; chromosome; chromosome, telomeric region; cytoplasm; cytosol; membrane; mitochondrion; nuclear body; nuclear envelope; nuclear replication fork; nucleolus; nucleoplasm; nucleus; protein-containing complex; protein-DNA complex; site of DNA damage; site of double-strand break; transcription regulator complex","Apoptosis","poly(ADP-ribose) polymerase 1","http://www.ncbi.nlm.nih.gov/gene/?term=142","142",null,"25591",null,null,null,"P09874","A0A0A6YVX0","P27008","A0A8I3N694","A0A5G2R0N8","F7EMW7","GO:0000785; GO:0005694; GO:0000781; GO:0005737; GO:0005829; GO:0016020; GO:0005739; GO:0016604; GO:0005635; GO:0043596; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0032993; GO:0090734; GO:0035861; GO:0005667","GO:0003824; GO:0003684; GO:0003677; GO:0019899; GO:0016757; GO:0042826; GO:0042802; GO:0046872; GO:0051287; GO:0140294; GO:0003950; GO:0140806; GO:1990404; GO:0140807; GO:0140815; GO:0140805; GO:0140808; GO:0030331; GO:0031491; GO:0016779; GO:0005515; GO:0042803; GO:0019901; GO:0047485; GO:0003723; GO:0061629; GO:0070412; GO:0046332; GO:0016740; GO:0008270","GO:0006915; GO:1990966; GO:0016051; GO:1904646; GO:0006974; GO:0032869; GO:1990090; GO:0034599; GO:0071560; GO:0034644; GO:0071294; GO:0046697; GO:0030592; GO:0006281; GO:0006302; GO:0002376; GO:0045087; GO:0030225; GO:0008152; GO:0032042; GO:0043504; GO:0007005; GO:2001170; GO:0045824; GO:1904357; GO:0000122; GO:0010613; GO:1905168; GO:0033148; GO:0051901; GO:1904762; GO:0060545; GO:1901216; GO:1900182; GO:1903518; GO:0060391; GO:0045944; GO:2000679; GO:0070213; GO:0016540; GO:0036211; GO:0070212; GO:0050790; GO:0045188; GO:0051052; GO:0044030; GO:1903376; GO:0032880; GO:0010990; GO:0071932; GO:1904044; GO:0010332; GO:0023019; GO:0000723; GO:0006366; GO:0007179","PTHR10459:SF112","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=270|UniProtKB=P09874","P00020"]
["PAX6",null,"PAX6","47","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1708",".CCP., .CP., .CSP., .DEV., .HHSP., .MIG., .OP., .OPA., .OT., .ST., .TRASR.",null,"PAIRED BOX PROTEIN PAX-6","anatomical structure development; animal organ morphogenesis; anterior/posterior pattern specification; astrocyte differentiation; axon guidance; axonogenesis; blood vessel development; brain development; camera-type eye development; cell differentiation; cell fate commitment; cell fate determination; cell population proliferation; cellular response to leukemia inhibitory factor; central nervous system development; cerebral cortex development; cerebral cortex regionalization; chromatin remodeling; commitment of neuronal cell to specific neuron type in forebrain; cornea development in camera-type eye; DNA demethylation; DNA methylation; dorsal/ventral axis specification; dorsal/ventral pattern formation; embryonic camera-type eye morphogenesis; establishment of mitotic spindle orientation; eye development; eye photoreceptor cell development; forebrain development; forebrain dorsal/ventral pattern formation; forebrain-midbrain boundary formation; gene expression; glandular epithelial cell differentiation; glucose homeostasis; habenula development; histone acetylation; iris morphogenesis; keratinocyte differentiation; lacrimal gland development; lens development in camera-type eye; negative regulation of epithelial cell proliferation; negative regulation of neural precursor cell proliferation; negative regulation of neuroblast proliferation; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of protein phosphorylation; negative regulation of transcription by RNA polymerase II; neural precursor cell proliferation; neuroblast proliferation; neuron differentiation; neuron fate commitment; neuron migration; oligodendrocyte cell fate specification; pallium development; pancreatic A cell development; pituitary gland development; positive regulation of core promoter binding; positive regulation of DNA-templated transcription; positive regulation of epithelial cell differentiation; positive regulation of gene expression; positive regulation of neuroblast proliferation; positive regulation of transcription by RNA polymerase II; protein localization to organelle; protein phosphorylation; regionalization; regulation of asymmetric cell division; regulation of cell migration; regulation of DNA-templated transcription; regulation of gene expression; regulation of neurogenesis; regulation of neuron differentiation; regulation of timing of cell differentiation; regulation of transcription by RNA polymerase II; response to wounding; retina development in camera-type eye; salivary gland morphogenesis; signal transduction involved in regulation of gene expression; smoothened signaling pathway; telencephalon regionalization; transcription by RNA polymerase II; type B pancreatic cell differentiation; ventral spinal cord development; visual perception","chromatin binding; chromatin DNA binding; co-SMAD binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone acetyltransferase binding; HMG box domain binding; nucleic acid binding; protein binding; protein kinase binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; R-SMAD binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coregulator binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus",null,"paired box 6","http://www.ncbi.nlm.nih.gov/gene/?term=5080","5080","18508","25509",null,null,null,"P26367","P63015","P63016",null,"A0A286ZPU0","A0A5F8AML4","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634","GO:0003682; GO:0031490; GO:0070410; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0035035; GO:0071837; GO:0003676; GO:0005515; GO:0019901; GO:0003723; GO:0000978; GO:0000979; GO:0070412; GO:0043565; GO:1990837; GO:0000976; GO:0001221; GO:0031625","GO:0048856; GO:0009887; GO:0009952; GO:0048708; GO:0007411; GO:0007409; GO:0001568; GO:0007420; GO:0043010; GO:0030154; GO:0045165; GO:0001709; GO:0008283; GO:1990830; GO:0007417; GO:0021987; GO:0021796; GO:0006338; GO:0021902; GO:0061303; GO:0080111; GO:0006306; GO:0009950; GO:0009953; GO:0048596; GO:0000132; GO:0001654; GO:0042462; GO:0030900; GO:0021798; GO:0021905; GO:0010467; GO:0002067; GO:0042593; GO:0021986; GO:0016573; GO:0061072; GO:0030216; GO:0032808; GO:0002088; GO:0050680; GO:2000178; GO:0007406; GO:0050768; GO:0045665; GO:0001933; GO:0000122; GO:0061351; GO:0007405; GO:0030182; GO:0048663; GO:0001764; GO:0021778; GO:0021543; GO:0003322; GO:0021983; GO:1904798; GO:0045893; GO:0030858; GO:0010628; GO:0002052; GO:0045944; GO:0033365; GO:0006468; GO:0003002; GO:0009786; GO:0030334; GO:0006355; GO:0010468; GO:0050767; GO:0045664; GO:0048505; GO:0006357; GO:0009611; GO:0060041; GO:0007435; GO:0023019; GO:0007224; GO:0021978; GO:0006366; GO:0003309; GO:0021517; GO:0007601","PTHR45636:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8620|UniProtKB=P26367"]
["Paxillin",null,"PXN","60","rb",null,2.1,1,8,8,3,3,"# 1239",".ANG., .CANCER., .CCKR., .CSP., .DEV., .INT., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TGFB., .TRASR., .VEGFS.","CCKR signaling map; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Angiogenesis","PAXILLIN","cell adhesion; cell migration; cellular response to reactive oxygen species; DNA-templated transcription; endothelial cell migration; growth hormone receptor signaling pathway; positive regulation of stress fiber assembly; signal complex assembly; signal transduction; substrate adhesion-dependent cell spreading; transforming growth factor beta receptor signaling pathway","beta-catenin binding; metal ion binding; neuropilin binding; protein binding; protein phosphatase binding; transcription coregulator activity; vinculin binding","anchoring junction; cell cortex; cell-cell junction; cytoplasm; cytoskeleton; cytosol; focal adhesion; lamellipodium; microtubule associated complex; plasma membrane; stress fiber","Cytoskeletal regulation / Adhesion","paxillin","http://www.ncbi.nlm.nih.gov/gene/?term=5829","5829","19303",null,null,null,null,"P49023","Q8VI36","A0A0G2JY12","A0A8I3Q0P3",null,"A0A1D5RC46","GO:0070161; GO:0005938; GO:0005911; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0030027; GO:0005875; GO:0005886; GO:0001725","GO:0008013; GO:0046872; GO:0038191; GO:0005515; GO:0019903; GO:0003712; GO:0017166","GO:0007155; GO:0016477; GO:0034614; GO:0006351; GO:0043542; GO:0060396; GO:0051496; GO:0007172; GO:0007165; GO:0034446; GO:0007179","PTHR24216:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9718|UniProtKB=P49023","P06959; P00056; P06664; P00034; P00005"]
["Pbx1 (PRL)",null,"PBX1","52, 42","rb",null,1,2.1,7,8,4,4,"# 1105",".CCP., .CCY., .CP., .OP., .OT., .TD., .TMAT., .TRASR.","Gonadotropin releasing hormone receptor pathway","PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 1","adrenal gland development; animal organ morphogenesis; anterior/posterior pattern specification; brain development; branching involved in ureteric bud morphogenesis; cell differentiation; cell population proliferation; embryonic hemopoiesis; embryonic limb morphogenesis; embryonic organ development; embryonic skeletal system development; eye development; G2/M transition of mitotic cell cycle; natural killer cell differentiation; negative regulation of neuron differentiation; neuron development; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; proximal/distal pattern formation; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of ossification; regulation of transcription by RNA polymerase II; sex differentiation; spleen development; stem cell proliferation; steroid biosynthetic process; thymus development; urogenital system development","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coregulator binding; transcription corepressor binding","chromatin; cytoplasm; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex","Lymphocyte signaling","PBX homeobox 1","http://www.ncbi.nlm.nih.gov/gene/?term=5087","5087","18514",null,null,null,null,"P40424","P41778",null,"A0A8I3PLF7","A0A287B0C0","A0A1D5QF10","GO:0000785; GO:0005737; GO:0005654; GO:0005634; GO:0090575; GO:0005667","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0005515; GO:0000978; GO:0000977; GO:0043565; GO:1990837; GO:0000976; GO:0001221; GO:0001222","GO:0030325; GO:0009887; GO:0009952; GO:0007420; GO:0001658; GO:0030154; GO:0008283; GO:0035162; GO:0030326; GO:0048568; GO:0048706; GO:0001654; GO:0000086; GO:0001779; GO:0045665; GO:0048666; GO:0010971; GO:2000648; GO:0045944; GO:0009954; GO:0042127; GO:0006355; GO:0030278; GO:0006357; GO:0007548; GO:0048536; GO:0072089; GO:0006694; GO:0048538; GO:0001655","PTHR11850:SF89","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8632|UniProtKB=P40424","P06664"]
["PCAF (KAT2B)",null,"KAT2B","93","rb",null,6.1,1.1000000000000001,8,8,8,8,"# 1052",".CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .DREP., .INS., .NOTCH., .OP., .OPA., .OT., .P53S., .SREME., .ST., .TRASR., .UBI.","p53 pathway; Gonadotropin releasing hormone receptor pathway","HISTONE ACETYLTRANSFERASE KAT2B","cell cycle; cellular response to insulin stimulus; chromatin remodeling; DNA-templated transcription; gluconeogenesis; heart development; histone acetylation; histone H3 acetylation; histone H3-K14 acetylation; internal peptidyl-lysine acetylation; limb development; monoubiquitinated histone deubiquitination; monoubiquitinated histone H2A deubiquitination; negative regulation of cell population proliferation; negative regulation of centriole replication; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of rRNA processing; N-terminal peptidyl-lysine acetylation; peptidyl-lysine acetylation; positive regulation of attachment of mitotic spindle microtubules to kinetochore; positive regulation of DNA-templated transcription; positive regulation of gluconeogenesis; positive regulation of transcription by RNA polymerase II; protein acetylation; regulation of cell cycle; regulation of cell division; regulation of DNA repair; regulation of DNA-templated transcription; regulation of embryonic development; regulation of histone deacetylation; regulation of protein ADP-ribosylation; regulation of RNA splicing; regulation of transcription by RNA polymerase II; regulation of tubulin deacetylation; rhythmic process; transcription initiation-coupled chromatin remodeling","acetyltransferase activity; acyltransferase activity; acyltransferase activity, transferring groups other than amino-acyl groups; chromatin binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; diamine N-acetyltransferase activity; DNA-binding transcription factor binding; histone acetyltransferase activity; histone deacetylase binding; histone H3 acetyltransferase activity; histone H3K9 acetyltransferase activity; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; peptide-lysine-N-acetyltransferase activity; protein binding; protein kinase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription coactivator activity; transcription coregulator activity; transferase activity","A band; actomyosin; ATAC complex; centrosome; cytoplasm; cytoskeleton; cytosol; histone acetyltransferase complex; I band; kinetochore; microtubule organizing center; mitotic spindle; nucleoplasm; nucleus; protein-containing complex; SAGA complex","Chromatin regulation / epigenetics","lysine acetyltransferase 2B","http://www.ncbi.nlm.nih.gov/gene/?term=8850","8850","18519",null,null,null,null,"Q92831","Q9JHD1","A0A8I5Y222","A0A8I3P556","I3LRW1","A0A5F7Z9G9","GO:0031672; GO:0042641; GO:0140672; GO:0005813; GO:0005737; GO:0005856; GO:0005829; GO:0000123; GO:0031674; GO:0000776; GO:0005815; GO:0072686; GO:0005654; GO:0005634; GO:0032991; GO:0000124","GO:0016407; GO:0016746; GO:0016747; GO:0003682; GO:0004861; GO:0004145; GO:0140297; GO:0004402; GO:0042826; GO:0010484; GO:0043992; GO:0004468; GO:0061733; GO:0005515; GO:0019901; GO:0000977; GO:0003713; GO:0003712; GO:0016740","GO:0007049; GO:0032869; GO:0006338; GO:0006351; GO:0006094; GO:0007507; GO:0016573; GO:0043966; GO:0044154; GO:0018393; GO:0060173; GO:0035521; GO:0035522; GO:0008285; GO:0046600; GO:0045736; GO:2000233; GO:0018076; GO:0018394; GO:1902425; GO:0045893; GO:0045722; GO:0045944; GO:0006473; GO:0051726; GO:0051302; GO:0006282; GO:0006355; GO:0045995; GO:0031063; GO:0010835; GO:0043484; GO:0006357; GO:0090043; GO:0048511; GO:0045815","PTHR45750:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8638|UniProtKB=Q92831","P00059; P06664"]
["PCK1",null,"PCK1","69","rb",null,4,2.1,4,4,4,4,"# 1129",".AMPK., .CSP., .FOXO., .IMU., .IMUR., .INS., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TCD., .TMAT., .TRASR.","Pyruvate metabolism","PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP]","cellular response to dexamethasone stimulus; cellular response to glucose stimulus; cellular response to insulin stimulus; cellular response to potassium ion starvation; gluconeogenesis; glucose homeostasis; glucose metabolic process; glycerol biosynthetic process from pyruvate; hepatocyte differentiation; lipid metabolic process; oxaloacetate metabolic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of memory T cell differentiation; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH; propionate catabolic process; regulation of lipid biosynthetic process; response to bacterium; response to insulin; response to lipid; response to starvation","carboxylic acid binding; carboxy-lyase activity; GTP binding; kinase activity; lyase activity; magnesium ion binding; manganese ion binding; metal ion binding; nucleotide binding; phosphoenolpyruvate carboxykinase (GTP) activity; phosphoenolpyruvate carboxykinase activity; protein serine kinase activity (using GTP as donor); purine nucleotide binding; transferase activity","cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; mitochondrion","Gluconeogenesis","phosphoenolpyruvate carboxykinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5105","5105","18534","362282","403560","100144531","696207","P35558","Q9Z2V4","P07379","A0A8I3QWQ0","A0A4X1UM84","F6ZDT7","GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0005739","GO:0031406; GO:0016831; GO:0005525; GO:0016301; GO:0016829; GO:0000287; GO:0030145; GO:0046872; GO:0000166; GO:0004613; GO:0004611; GO:0106264; GO:0017076; GO:0016740","GO:0071549; GO:0071333; GO:0032869; GO:0051365; GO:0006094; GO:0042593; GO:0006006; GO:0046327; GO:0070365; GO:0006629; GO:0006107; GO:0018105; GO:0016310; GO:0043382; GO:0061402; GO:0019543; GO:0046890; GO:0009617; GO:0032868; GO:0033993; GO:0042594","PTHR11561:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8724|UniProtKB=P35558","P02772"]
["PCNA",null,"PCNA","31","rt",null,1,4,8,8,2,1,"# 0256",".CCP., .CCY., .CD., .CSP., .DDR., .DI., .DREP., .DRR., .HEPB., .OP., .OT., .OXS., .SREME., .TRASR.","DNA replication","PROLIFERATING CELL NUCLEAR ANTIGEN","base-excision repair, gap-filling; cellular response to DNA damage stimulus; cellular response to hydrogen peroxide; cellular response to UV; cellular response to xenobiotic stimulus; DNA repair; DNA replication; epithelial cell differentiation; estrous cycle; heart development; leading strand elongation; liver regeneration; mismatch repair; mitotic telomere maintenance via semi-conservative replication; negative regulation of transcription by RNA polymerase II; positive regulation of deoxyribonuclease activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of DNA-directed DNA polymerase activity; regulation of DNA replication; replication fork processing; response to cadmium ion; response to dexamethasone; response to estradiol; response to L-glutamate; response to lipid; response to oxidative stress; translesion synthesis","chromatin binding; damaged DNA binding; dinucleotide insertion or deletion binding; DNA binding; DNA polymerase binding; DNA polymerase processivity factor activity; enzyme binding; histone acetyltransferase binding; identical protein binding; MutLalpha complex binding; nuclear estrogen receptor binding; protein binding; protein C-terminus binding; protein-containing complex binding; purine-specific mismatch base pair DNA N-glycosylase activity; receptor tyrosine kinase binding","centrosome; chromatin; chromosome, telomeric region; cyclin-dependent protein kinase holoenzyme complex; extracellular exosome; male germ cell nucleus; nuclear body; nuclear lamina; nuclear replication fork; nucleoplasm; nucleus; PCNA complex; PCNA-p21 complex; replication fork; replisome","Proliferation / mitotic marker","proliferating cell nuclear antigen","http://www.ncbi.nlm.nih.gov/gene/?term=5111","5111","18538","25737","477166",null,"718006","P12004","P17918","P04961","A0A8I3QKL0","A0A287ABG2","F6ZD63","GO:0005813; GO:0000785; GO:0000781; GO:0000307; GO:0070062; GO:0001673; GO:0016604; GO:0005652; GO:0043596; GO:0005654; GO:0005634; GO:0043626; GO:0070557; GO:0005657; GO:0030894","GO:0003682; GO:0003684; GO:0032139; GO:0003677; GO:0070182; GO:0030337; GO:0019899; GO:0035035; GO:0042802; GO:0032405; GO:0030331; GO:0005515; GO:0008022; GO:0044877; GO:0000701; GO:0030971","GO:0006287; GO:0006974; GO:0070301; GO:0034644; GO:0071466; GO:0006281; GO:0006260; GO:0030855; GO:0044849; GO:0007507; GO:0006272; GO:0097421; GO:0006298; GO:1902990; GO:0000122; GO:0032077; GO:0045739; GO:0045740; GO:1900264; GO:0006275; GO:0031297; GO:0046686; GO:0071548; GO:0032355; GO:1902065; GO:0033993; GO:0006979; GO:0019985","PTHR11352:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8729|UniProtKB=P12004","P00017"]
["PDCD4",null,"PDCD4","60","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2207",".APO., .BMP., .CCP., .CD., .CP., .CSP., .DEV., .IMFR., .IMUF., .IMUR., .JNK., .MAPK., .NFKB., .OP., .OT., .RTK., .SREME., .TRASR.",null,"PROGRAMMED CELL DEATH PROTEIN 4","apoptotic process; BMP signaling pathway; cellular response to lipopolysaccharide; epithelial to mesenchymal transition involved in cardiac fibroblast development; negative regulation of apoptotic process; negative regulation of cytokine production involved in inflammatory response; negative regulation of DNA-templated transcription; negative regulation of JUN kinase activity; negative regulation of myofibroblast differentiation; negative regulation of vascular associated smooth muscle cell differentiation; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of endothelial cell apoptotic process; positive regulation of inflammatory response; positive regulation of NIK/NF-kappaB signaling; positive regulation of smooth muscle cell apoptotic process; positive regulation of vascular associated smooth muscle cell apoptotic process; regulation of protein metabolic process","protein binding; RNA binding","cytoplasm; cytosol; nucleus",null,"programmed cell death 4","http://www.ncbi.nlm.nih.gov/gene/?term=27250","27250","18569","64031",null,null,"695345","Q53EL6","Q61823","Q9JID1","A0A8I3Q261","A0A287B6S3","G7N146","GO:0005737; GO:0005829; GO:0005634","GO:0005515; GO:0003723","GO:0006915; GO:0030509; GO:0071222; GO:0060940; GO:0043066; GO:1900016; GO:0045892; GO:0043508; GO:1904761; GO:1905064; GO:1904706; GO:2000353; GO:0050729; GO:1901224; GO:0034393; GO:1905461; GO:0051246","PTHR12626:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8763|UniProtKB=Q53EL6"]
["PDGF receptor beta",null,"PDGFRB","190","rb",null,1,7,2,2,1,2,"# 0576",".ANG., .APO., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .GLI., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT.","PDGF signaling pathway; Angiogenesis","PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA","aging; angiogenesis; aorta morphogenesis; cardiac myofibril assembly; cell chemotaxis; cell migration; cell migration involved in coronary angiogenesis; cell migration involved in vasculogenesis; cellular response to platelet-derived growth factor stimulus; chemotaxis; G protein-coupled receptor signaling pathway; glycosaminoglycan biosynthetic process; inner ear development; intracellular signal transduction; lung growth; male gonad development; metanephric comma-shaped body morphogenesis; metanephric glomerular capillary formation; metanephric glomerular mesangial cell proliferation involved in metanephros development; metanephric glomerulus morphogenesis; metanephric mesenchymal cell migration; metanephric mesenchyme development; metanephric S-shaped body morphogenesis; negative regulation of apoptotic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet-derived growth factor receptor signaling pathway; platelet-derived growth factor receptor-beta signaling pathway; positive regulation of apoptotic process; positive regulation of calcium ion import; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of chemotaxis; positive regulation of collagen biosynthetic process; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of hepatic stellate cell activation; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; positive regulation of mitotic nuclear division; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase C activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein modification process; positive regulation of reactive oxygen species metabolic process; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; response to estradiol; response to estrogen; response to fluid shear stress; response to hydrogen peroxide; response to hyperoxia; response to lipid; response to organic cyclic compound; response to retinoic acid; response to toxic substance; retina vasculature development in camera-type eye; signal transduction; smooth muscle cell chemotaxis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor signaling pathway; wound healing","ATP binding; enzyme binding; growth factor binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor activity; platelet-derived growth factor receptor binding; protein binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; signaling receptor binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding","apical plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle; focal adhesion; Golgi apparatus; intracellular membrane-bounded organelle; lysosomal lumen; lysosome; membrane; nucleus; plasma membrane; receptor complex","Tyrosine kinase / adaptor","platelet derived growth factor receptor beta","http://www.ncbi.nlm.nih.gov/gene/?term=5159","5159","18596",null,null,null,null,"P09619","P05622","A0A8L2QV39","A0A8P0N3S2",null,"A0A1D5Q2Y8","GO:0016324; GO:0009986; GO:0005737; GO:0031410; GO:0005925; GO:0005794; GO:0043231; GO:0043202; GO:0005764; GO:0016020; GO:0005634; GO:0005886; GO:0043235","GO:0005524; GO:0019899; GO:0019838; GO:0016301; GO:0000166; GO:0043548; GO:0004992; GO:0005019; GO:0048407; GO:0005017; GO:0005161; GO:0005515; GO:0004672; GO:0019901; GO:0004713; GO:0005102; GO:0016740; GO:0004714; GO:0038085","GO:0007568; GO:0001525; GO:0035909; GO:0055003; GO:0060326; GO:0016477; GO:0060981; GO:0035441; GO:0036120; GO:0006935; GO:0007186; GO:0006024; GO:0048839; GO:0035556; GO:0060437; GO:0008584; GO:0072278; GO:0072277; GO:0072262; GO:0072275; GO:0035789; GO:0072075; GO:0072284; GO:0043066; GO:0018108; GO:0046488; GO:0048015; GO:0016310; GO:0048008; GO:0035791; GO:0043065; GO:0090280; GO:0030335; GO:0008284; GO:0038091; GO:0050921; GO:0032967; GO:2000573; GO:0070374; GO:0048146; GO:2000491; GO:0033674; GO:0043406; GO:0043410; GO:0035793; GO:0045840; GO:0043552; GO:0014068; GO:0010863; GO:0032516; GO:0031401; GO:2000379; GO:0035025; GO:0014911; GO:0048661; GO:0046777; GO:0006468; GO:0032956; GO:0032355; GO:0043627; GO:0034405; GO:0042542; GO:0055093; GO:0033993; GO:0014070; GO:0032526; GO:0009636; GO:0061298; GO:0007165; GO:0071670; GO:0007169; GO:0038084; GO:0042060","PTHR24416:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8804|UniProtKB=P09619","P00047; P00005"]
["PDGF receptor beta - phospho","Tyr751","PDGFRB","190","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0570",".ANG., .APO., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .GLI., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT.","PDGF signaling pathway; Angiogenesis","PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA","aging; angiogenesis; aorta morphogenesis; cardiac myofibril assembly; cell chemotaxis; cell migration; cell migration involved in coronary angiogenesis; cell migration involved in vasculogenesis; cellular response to platelet-derived growth factor stimulus; chemotaxis; G protein-coupled receptor signaling pathway; glycosaminoglycan biosynthetic process; inner ear development; intracellular signal transduction; lung growth; male gonad development; metanephric comma-shaped body morphogenesis; metanephric glomerular capillary formation; metanephric glomerular mesangial cell proliferation involved in metanephros development; metanephric glomerulus morphogenesis; metanephric mesenchymal cell migration; metanephric mesenchyme development; metanephric S-shaped body morphogenesis; negative regulation of apoptotic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet-derived growth factor receptor signaling pathway; platelet-derived growth factor receptor-beta signaling pathway; positive regulation of apoptotic process; positive regulation of calcium ion import; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of chemotaxis; positive regulation of collagen biosynthetic process; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of hepatic stellate cell activation; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; positive regulation of mitotic nuclear division; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase C activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein modification process; positive regulation of reactive oxygen species metabolic process; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; response to estradiol; response to estrogen; response to fluid shear stress; response to hydrogen peroxide; response to hyperoxia; response to lipid; response to organic cyclic compound; response to retinoic acid; response to toxic substance; retina vasculature development in camera-type eye; signal transduction; smooth muscle cell chemotaxis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor signaling pathway; wound healing","ATP binding; enzyme binding; growth factor binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor activity; platelet-derived growth factor receptor binding; protein binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; signaling receptor binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding","apical plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle; focal adhesion; Golgi apparatus; intracellular membrane-bounded organelle; lysosomal lumen; lysosome; membrane; nucleus; plasma membrane; receptor complex","Tyrosine kinase / adaptor","platelet derived growth factor receptor beta","http://www.ncbi.nlm.nih.gov/gene/?term=5159","5159","18596",null,null,null,null,"P09619","P05622","A0A8L2QV39","A0A8P0N3S2",null,"A0A1D5Q2Y8","GO:0016324; GO:0009986; GO:0005737; GO:0031410; GO:0005925; GO:0005794; GO:0043231; GO:0043202; GO:0005764; GO:0016020; GO:0005634; GO:0005886; GO:0043235","GO:0005524; GO:0019899; GO:0019838; GO:0016301; GO:0000166; GO:0043548; GO:0004992; GO:0005019; GO:0048407; GO:0005017; GO:0005161; GO:0005515; GO:0004672; GO:0019901; GO:0004713; GO:0005102; GO:0016740; GO:0004714; GO:0038085","GO:0007568; GO:0001525; GO:0035909; GO:0055003; GO:0060326; GO:0016477; GO:0060981; GO:0035441; GO:0036120; GO:0006935; GO:0007186; GO:0006024; GO:0048839; GO:0035556; GO:0060437; GO:0008584; GO:0072278; GO:0072277; GO:0072262; GO:0072275; GO:0035789; GO:0072075; GO:0072284; GO:0043066; GO:0018108; GO:0046488; GO:0048015; GO:0016310; GO:0048008; GO:0035791; GO:0043065; GO:0090280; GO:0030335; GO:0008284; GO:0038091; GO:0050921; GO:0032967; GO:2000573; GO:0070374; GO:0048146; GO:2000491; GO:0033674; GO:0043406; GO:0043410; GO:0035793; GO:0045840; GO:0043552; GO:0014068; GO:0010863; GO:0032516; GO:0031401; GO:2000379; GO:0035025; GO:0014911; GO:0048661; GO:0046777; GO:0006468; GO:0032956; GO:0032355; GO:0043627; GO:0034405; GO:0042542; GO:0055093; GO:0033993; GO:0014070; GO:0032526; GO:0009636; GO:0061298; GO:0007165; GO:0071670; GO:0007169; GO:0038084; GO:0042060","PTHR24416:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8804|UniProtKB=P09619","P00047; P00005"]
["PDGF receptor beta - phospho","Tyr751","PDGFRB","190","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0578",".ANG., .APO., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .GLI., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT.","PDGF signaling pathway; Angiogenesis","PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA","aging; angiogenesis; aorta morphogenesis; cardiac myofibril assembly; cell chemotaxis; cell migration; cell migration involved in coronary angiogenesis; cell migration involved in vasculogenesis; cellular response to platelet-derived growth factor stimulus; chemotaxis; G protein-coupled receptor signaling pathway; glycosaminoglycan biosynthetic process; inner ear development; intracellular signal transduction; lung growth; male gonad development; metanephric comma-shaped body morphogenesis; metanephric glomerular capillary formation; metanephric glomerular mesangial cell proliferation involved in metanephros development; metanephric glomerulus morphogenesis; metanephric mesenchymal cell migration; metanephric mesenchyme development; metanephric S-shaped body morphogenesis; negative regulation of apoptotic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet-derived growth factor receptor signaling pathway; platelet-derived growth factor receptor-beta signaling pathway; positive regulation of apoptotic process; positive regulation of calcium ion import; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of chemotaxis; positive regulation of collagen biosynthetic process; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of hepatic stellate cell activation; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; positive regulation of mitotic nuclear division; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase C activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein modification process; positive regulation of reactive oxygen species metabolic process; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; protein autophosphorylation; protein phosphorylation; regulation of actin cytoskeleton organization; response to estradiol; response to estrogen; response to fluid shear stress; response to hydrogen peroxide; response to hyperoxia; response to lipid; response to organic cyclic compound; response to retinoic acid; response to toxic substance; retina vasculature development in camera-type eye; signal transduction; smooth muscle cell chemotaxis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor signaling pathway; wound healing","ATP binding; enzyme binding; growth factor binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor activity; platelet-derived growth factor receptor binding; protein binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; signaling receptor binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding","apical plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle; focal adhesion; Golgi apparatus; intracellular membrane-bounded organelle; lysosomal lumen; lysosome; membrane; nucleus; plasma membrane; receptor complex","Tyrosine kinase / adaptor","platelet derived growth factor receptor beta","http://www.ncbi.nlm.nih.gov/gene/?term=5159","5159","18596",null,null,null,null,"P09619","P05622","A0A8L2QV39","A0A8P0N3S2",null,"A0A1D5Q2Y8","GO:0016324; GO:0009986; GO:0005737; GO:0031410; GO:0005925; GO:0005794; GO:0043231; GO:0043202; GO:0005764; GO:0016020; GO:0005634; GO:0005886; GO:0043235","GO:0005524; GO:0019899; GO:0019838; GO:0016301; GO:0000166; GO:0043548; GO:0004992; GO:0005019; GO:0048407; GO:0005017; GO:0005161; GO:0005515; GO:0004672; GO:0019901; GO:0004713; GO:0005102; GO:0016740; GO:0004714; GO:0038085","GO:0007568; GO:0001525; GO:0035909; GO:0055003; GO:0060326; GO:0016477; GO:0060981; GO:0035441; GO:0036120; GO:0006935; GO:0007186; GO:0006024; GO:0048839; GO:0035556; GO:0060437; GO:0008584; GO:0072278; GO:0072277; GO:0072262; GO:0072275; GO:0035789; GO:0072075; GO:0072284; GO:0043066; GO:0018108; GO:0046488; GO:0048015; GO:0016310; GO:0048008; GO:0035791; GO:0043065; GO:0090280; GO:0030335; GO:0008284; GO:0038091; GO:0050921; GO:0032967; GO:2000573; GO:0070374; GO:0048146; GO:2000491; GO:0033674; GO:0043406; GO:0043410; GO:0035793; GO:0045840; GO:0043552; GO:0014068; GO:0010863; GO:0032516; GO:0031401; GO:2000379; GO:0035025; GO:0014911; GO:0048661; GO:0046777; GO:0006468; GO:0032956; GO:0032355; GO:0043627; GO:0034405; GO:0042542; GO:0055093; GO:0033993; GO:0014070; GO:0032526; GO:0009636; GO:0061298; GO:0007165; GO:0071670; GO:0007169; GO:0038084; GO:0042060","PTHR24416:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8804|UniProtKB=P09619","P00047; P00005"]
["PDI",null,"P4HB","57","rb",null,2.1,1,2,2,2,2,"# 0693",".CSP., .HIF., .IMUF., .INFM., .SREME.",null,"PROTEIN DISULFIDE-ISOMERASE","cellular response to hypoxia; cellular response to interleukin-7; endoplasmic reticulum to Golgi vesicle-mediated transport; insulin processing; interleukin-12-mediated signaling pathway; interleukin-23-mediated signaling pathway; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; positive regulation of cell adhesion; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; protein folding; protein folding in endoplasmic reticulum; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; response to endoplasmic reticulum stress","actin binding; enzyme binding; integrin binding; isomerase activity; procollagen-proline 4-dioxygenase activity; protein binding; protein disulfide isomerase activity; protein heterodimerization activity; protein-containing complex binding; protein-disulfide reductase activity; RNA binding; thiol oxidase activity","cytoskeleton; cytosol; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; extracellular exosome; extracellular region; focal adhesion; lamellipodium; melanosome; membrane; plasma membrane; procollagen-proline 4-dioxygenase complex; protein-containing complex","Translational control","prolyl 4-hydroxylase subunit beta","http://www.ncbi.nlm.nih.gov/gene/?term=5034","5034","18453","25506","483369",null,null,"P07237","P09103","P04785","A0A8P0N8H7",null,"A0A1D5RKD4","GO:0005856; GO:0005829; GO:0005783; GO:0034663; GO:0005788; GO:0005793; GO:0009897; GO:0070062; GO:0005576; GO:0005925; GO:0030027; GO:0042470; GO:0016020; GO:0005886; GO:0016222; GO:0032991","GO:0003779; GO:0019899; GO:0005178; GO:0016853; GO:0004656; GO:0005515; GO:0003756; GO:0046982; GO:0044877; GO:0015035; GO:0003723; GO:0016972","GO:0071456; GO:0098761; GO:0006888; GO:0030070; GO:0035722; GO:0038155; GO:0018401; GO:0045785; GO:1900026; GO:0046598; GO:0006457; GO:0034975; GO:1902175; GO:0034976","PTHR18929:SF101","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8548|UniProtKB=P07237"]
["PDK1",null,"PDK1","68-58","rb",null,2,2.1,8,7,1.1000000000000001,1.1000000000000001,"# 1178",".APO., .CAMET., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .HIF., .OP., .OPA., .SREME., .ST.",null,"[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL","carbohydrate metabolic process; cell population proliferation; glucose metabolic process; hypoxia-inducible factor-1alpha signaling pathway; intrinsic apoptotic signaling pathway in response to oxidative stress; phosphorylation; protein phosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of glucose metabolic process","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity","mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion","Akt signaling / metabolism","pyruvate dehydrogenase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5163","5163","228026",null,null,null,"697772","Q15118","Q8BFP9","A0A8I6GMB0","A0A8P0SHX6","A0A286ZQW2","F7GNV0","GO:0005759; GO:0005967; GO:0005739","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004740; GO:0016740","GO:0005975; GO:0008283; GO:0006006; GO:0097411; GO:0008631; GO:0016310; GO:0006468; GO:0010510; GO:0010906","PTHR11947:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8809|UniProtKB=Q15118"]
["PDK1 - phospho","Ser241","PDK1","68-58","rb",null,2,2,1,1,2,2,"# 1834",".APO., .CAMET., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .HIF., .OP., .OPA., .SREME., .ST.",null,"[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL","carbohydrate metabolic process; cell population proliferation; glucose metabolic process; hypoxia-inducible factor-1alpha signaling pathway; intrinsic apoptotic signaling pathway in response to oxidative stress; phosphorylation; protein phosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of glucose metabolic process","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity","mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion","Akt signaling / metabolism","pyruvate dehydrogenase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5163","5163","228026",null,null,null,"697772","Q15118","Q8BFP9","A0A8I6GMB0","A0A8P0SHX6","A0A286ZQW2","F7GNV0","GO:0005759; GO:0005967; GO:0005739","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004740; GO:0016740","GO:0005975; GO:0008283; GO:0006006; GO:0097411; GO:0008631; GO:0016310; GO:0006468; GO:0010510; GO:0010906","PTHR11947:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8809|UniProtKB=Q15118"]
["PDK1 (PDHK1)",null,"PDK1","47","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2833",".APO., .CAMET., .CANCER., .CCP., .CD., .CP., .CSP., .HIF., .OP., .OPA., .SREME., .ST.",null,"[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL","carbohydrate metabolic process; cell population proliferation; glucose metabolic process; hypoxia-inducible factor-1alpha signaling pathway; intrinsic apoptotic signaling pathway in response to oxidative stress; phosphorylation; protein phosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of glucose metabolic process","ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity","mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion","Akt signaling / metabolism","pyruvate dehydrogenase kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5163","5163","228026",null,null,null,"697772","Q15118","Q8BFP9","A0A8I6GMB0","A0A8P0SHX6","A0A286ZQW2","F7GNV0","GO:0005759; GO:0005967; GO:0005739","GO:0005524; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004740; GO:0016740","GO:0005975; GO:0008283; GO:0006006; GO:0097411; GO:0008631; GO:0016310; GO:0006468; GO:0010510; GO:0010906","PTHR11947:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8809|UniProtKB=Q15118"]
["PEA-15 (PED)",null,"PEA15","15","rb",null,2,7,6,2,7,7,"# 0403",".APO., .CD., .CSP., .MAPK., .RTK.","Gonadotropin releasing hormone receptor pathway","ASTROCYTIC PHOSPHOPROTEIN PEA-15","apoptotic process; carbohydrate transport; MAPK cascade; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of glucose import; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of apoptotic process; response to morphine","protein binding","cytoplasm; cytosol; microtubule associated complex; nucleoplasm","Apoptosis / autophagy","proliferation and apoptosis adaptor protein 15","http://www.ncbi.nlm.nih.gov/gene/?term=8682","8682","18611","364052",null,null,null,"Q15121","Q62048","Q5U318","A0A8I3QPA9",null,null,"GO:0005737; GO:0005829; GO:0005875; GO:0005654","GO:0005515","GO:0006915; GO:0008643; GO:0000165; GO:1902042; GO:0046325; GO:1902043; GO:0042981; GO:0043278","PTHR48169:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8822|UniProtKB=Q15121","P06664"]
["PEA-15 (PED) - phospho","Ser104","PEA15","15","rb",null,1,7,7,1,8,8,"# 0402",".APO., .CD., .CSP., .MAPK., .RTK.","Gonadotropin releasing hormone receptor pathway","ASTROCYTIC PHOSPHOPROTEIN PEA-15","apoptotic process; carbohydrate transport; MAPK cascade; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of glucose import; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of apoptotic process; response to morphine","protein binding","cytoplasm; cytosol; microtubule associated complex; nucleoplasm","Apoptosis / autophagy","proliferation and apoptosis adaptor protein 15","http://www.ncbi.nlm.nih.gov/gene/?term=8682","8682","18611","364052",null,null,null,"Q15121","Q62048","Q5U318","A0A8I3QPA9",null,null,"GO:0005737; GO:0005829; GO:0005875; GO:0005654","GO:0005515","GO:0006915; GO:0008643; GO:0000165; GO:1902042; GO:0046325; GO:1902043; GO:0042981; GO:0043278","PTHR48169:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8822|UniProtKB=Q15121","P06664"]
["PERK",null,"EIF2AK3","140","rb",null,6,4,8,8,8,8,"# 0455",".ALZ., .ANG., .APH., .APO., .CANCER., .CD., .CSP., .DI., .INS., .OP., .OPA., .OT., .SREME., .ST., .TRASR.","Gonadotropin releasing hormone receptor pathway","EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3","activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; bone mineralization; calcium-mediated signaling; cellular response to amino acid starvation; cellular response to cold; cellular response to glucose starvation; chondrocyte development; eiF2alpha phosphorylation in response to endoplasmic reticulum stress; endocrine pancreas development; endoplasmic reticulum organization; endoplasmic reticulum unfolded protein response; ER overload response; insulin-like growth factor receptor signaling pathway; negative regulation of myelination; negative regulation of translation; negative regulation of translation in response to stress; negative regulation of translational initiation in response to stress; ossification; peptidyl-serine phosphorylation; PERK-mediated unfolded protein response; phosphorylation; positive regulation of gene expression; positive regulation of protein localization to nucleus; positive regulation of transcription by RNA polymerase I; positive regulation of vascular endothelial growth factor production; protein autophosphorylation; protein phosphorylation; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; regulation of gene expression; regulation of nitrogen compound metabolic process; regulation of primary metabolic process; regulation of translation; regulation of translational initiation by eIF2 alpha phosphorylation; response to endoplasmic reticulum stress; response to manganese-induced endoplasmic reticulum stress; response to unfolded protein; skeletal system development","ATP binding; enzyme binding; eukaryotic translation initiation factor 2alpha kinase activity; Hsp90 protein binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm","Translational control","eukaryotic translation initiation factor 2 alpha kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=9451","9451","13666","29702","475756",null,null,"Q9NZJ5","A0A0R4J1Y1","Q9Z1Z1","A0A8P0NA05","A0A286ZM33","A0A5F7ZIY4","GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0048471","GO:0005524; GO:0019899; GO:0004694; GO:0051879; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0016740","GO:0006919; GO:0001525; GO:0030282; GO:0019722; GO:0034198; GO:0070417; GO:0042149; GO:0002063; GO:0036492; GO:0031018; GO:0007029; GO:0030968; GO:0006983; GO:0048009; GO:0031642; GO:0017148; GO:0032055; GO:0032057; GO:0001503; GO:0018105; GO:0036499; GO:0016310; GO:0010628; GO:1900182; GO:0045943; GO:0010575; GO:0046777; GO:0006468; GO:0060734; GO:1902235; GO:0010468; GO:0051171; GO:0080090; GO:0006417; GO:0010998; GO:0034976; GO:1990737; GO:0006986; GO:0001501","PTHR11042:SF166","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3255|UniProtKB=Q9NZJ5","P06664"]
["PERK - phospho","Thr980","EIF2AK3","125","rb",null,6.1,6,"n/a","n/a","n/a","n/a","# 0715",".ALZ., .ANG., .APH., .APO., .CANCER., .CD., .CSP., .DI., .INS., .OP., .OPA., .OT., .SREME., .ST., .TRASR.","Gonadotropin releasing hormone receptor pathway","EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3","activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; bone mineralization; calcium-mediated signaling; cellular response to amino acid starvation; cellular response to cold; cellular response to glucose starvation; chondrocyte development; eiF2alpha phosphorylation in response to endoplasmic reticulum stress; endocrine pancreas development; endoplasmic reticulum organization; endoplasmic reticulum unfolded protein response; ER overload response; insulin-like growth factor receptor signaling pathway; negative regulation of myelination; negative regulation of translation; negative regulation of translation in response to stress; negative regulation of translational initiation in response to stress; ossification; peptidyl-serine phosphorylation; PERK-mediated unfolded protein response; phosphorylation; positive regulation of gene expression; positive regulation of protein localization to nucleus; positive regulation of transcription by RNA polymerase I; positive regulation of vascular endothelial growth factor production; protein autophosphorylation; protein phosphorylation; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; regulation of gene expression; regulation of nitrogen compound metabolic process; regulation of primary metabolic process; regulation of translation; regulation of translational initiation by eIF2 alpha phosphorylation; response to endoplasmic reticulum stress; response to manganese-induced endoplasmic reticulum stress; response to unfolded protein; skeletal system development","ATP binding; enzyme binding; eukaryotic translation initiation factor 2alpha kinase activity; Hsp90 protein binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm","Translational control","eukaryotic translation initiation factor 2 alpha kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=9451","9451","13666","29702","475756",null,null,"Q9NZJ5","A0A0R4J1Y1","Q9Z1Z1","A0A8P0NA05","A0A286ZM33","A0A5F7ZIY4","GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0048471","GO:0005524; GO:0019899; GO:0004694; GO:0051879; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0016740","GO:0006919; GO:0001525; GO:0030282; GO:0019722; GO:0034198; GO:0070417; GO:0042149; GO:0002063; GO:0036492; GO:0031018; GO:0007029; GO:0030968; GO:0006983; GO:0048009; GO:0031642; GO:0017148; GO:0032055; GO:0032057; GO:0001503; GO:0018105; GO:0036499; GO:0016310; GO:0010628; GO:1900182; GO:0045943; GO:0010575; GO:0046777; GO:0006468; GO:0060734; GO:1902235; GO:0010468; GO:0051171; GO:0080090; GO:0006417; GO:0010998; GO:0034976; GO:1990737; GO:0006986; GO:0001501","PTHR11042:SF166","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3255|UniProtKB=Q9NZJ5","P06664"]
["PGAM1",null,"PGAM1","28","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2842",".CAMET., .CANCER., .CSP., .OP., .OPA., .ST.","Glycolysis","PHOSPHOGLYCERATE MUTASE 1","glycolytic process; regulation of glycolytic process; regulation of pentose-phosphate shunt; respiratory burst","2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; catalytic activity; hydrolase activity; intramolecular transferase activity, phosphotransferases; isomerase activity; phosphoglycerate mutase activity; protein binding; protein kinase binding","cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; membrane; secretory granule lumen",null,"phosphoglycerate mutase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5223","5223","18648","24642",null,"100154776","696959","P18669","Q9DBJ1","P25113",null,"A0A287AJQ2","F7CUY7","GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1904813; GO:0016020; GO:0034774","GO:0046538; GO:0004082; GO:0003824; GO:0016787; GO:0016868; GO:0016853; GO:0004619; GO:0005515; GO:0019901","GO:0006096; GO:0006110; GO:0043456; GO:0045730","PTHR11931:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8888|UniProtKB=P18669","P00024"]
["PGC-1 alpha",null,"PPARGC1A","113, 38","ms",null,4,2.1,"n/a","n/a","n/a","n/a","# 1407",".AMPK., .APO., .CCP., .CD., .CP., .CSP., .DI., .HUNT., .INS., .OP., .OT., .OXS., .SREME., .TRASR.",null,"PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA","adipose tissue development; brown fat cell differentiation; cellular glucose homeostasis; cellular respiration; cellular response to oxidative stress; circadian regulation of gene expression; digestion; energy homeostasis; fatty acid oxidation; gluconeogenesis; mitochondrion organization; mRNA processing; negative regulation of neuron apoptotic process; negative regulation of neuron death; negative regulation of smooth muscle cell proliferation; neuron apoptotic process; positive regulation of ATP biosynthetic process; positive regulation of cellular respiration; positive regulation of cold-induced thermogenesis; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fatty acid oxidation; positive regulation of gene expression; positive regulation of gluconeogenesis; positive regulation of histone acetylation; positive regulation of mitochondrial DNA metabolic process; positive regulation of mitochondrion organization; positive regulation of muscle tissue development; positive regulation of transcription by RNA polymerase II; protein stabilization; protein-containing complex assembly; regulation of circadian rhythm; regulation of DNA-templated transcription; respiratory electron transport chain; response to dietary excess; response to muscle activity; response to starvation; rhythmic process; RNA splicing; temperature homeostasis; transcription initiation at RNA polymerase II promoter","chromatin DNA binding; DNA binding; DNA-binding transcription factor binding; nuclear receptor binding; nuclear receptor coactivator activity; nucleic acid binding; protein binding; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription coregulator activity; ubiquitin protein ligase binding","chromatin; cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus; PML body","Metabolism","PPARG coactivator 1 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=10891","10891","19017",null,null,"397013",null,"Q9UBK2","O70343","A0A8I5Y905","A0A8I3MZ45","Q865B6","A0A1D5QEZ6","GO:0000785; GO:0005737; GO:0043231; GO:0005654; GO:0005634; GO:0016605","GO:0031490; GO:0003677; GO:0140297; GO:0016922; GO:0030374; GO:0003676; GO:0005515; GO:0003723; GO:0061629; GO:0043565; GO:0003713; GO:0003712; GO:0031625","GO:0060612; GO:0050873; GO:0001678; GO:0045333; GO:0034599; GO:0032922; GO:0007586; GO:0097009; GO:0019395; GO:0006094; GO:0007005; GO:0006397; GO:0043524; GO:1901215; GO:0048662; GO:0051402; GO:2001171; GO:1901857; GO:0120162; GO:0051091; GO:0045893; GO:0046321; GO:0010628; GO:0045722; GO:0035066; GO:1901860; GO:0010822; GO:1901863; GO:0045944; GO:0050821; GO:0065003; GO:0042752; GO:0006355; GO:0022904; GO:0002021; GO:0014850; GO:0042594; GO:0048511; GO:0008380; GO:0001659; GO:0006367","PTHR15528:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9237|UniProtKB=Q9UBK2"]
["PGC-1 alpha - phospho","Ser571","PPARGC1A","91","rb",null,7,2,1,1,6,6,"# 1424",".AMPK., .APO., .CCP., .CD., .CP., .CSP., .DI., .HUNT., .INS., .OP., .OT., .OXS., .SREME., .TRASR.",null,"PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA","adipose tissue development; brown fat cell differentiation; cellular glucose homeostasis; cellular respiration; cellular response to oxidative stress; circadian regulation of gene expression; digestion; energy homeostasis; fatty acid oxidation; gluconeogenesis; mitochondrion organization; mRNA processing; negative regulation of neuron apoptotic process; negative regulation of neuron death; negative regulation of smooth muscle cell proliferation; neuron apoptotic process; positive regulation of ATP biosynthetic process; positive regulation of cellular respiration; positive regulation of cold-induced thermogenesis; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fatty acid oxidation; positive regulation of gene expression; positive regulation of gluconeogenesis; positive regulation of histone acetylation; positive regulation of mitochondrial DNA metabolic process; positive regulation of mitochondrion organization; positive regulation of muscle tissue development; positive regulation of transcription by RNA polymerase II; protein stabilization; protein-containing complex assembly; regulation of circadian rhythm; regulation of DNA-templated transcription; respiratory electron transport chain; response to dietary excess; response to muscle activity; response to starvation; rhythmic process; RNA splicing; temperature homeostasis; transcription initiation at RNA polymerase II promoter","chromatin DNA binding; DNA binding; DNA-binding transcription factor binding; nuclear receptor binding; nuclear receptor coactivator activity; nucleic acid binding; protein binding; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription coregulator activity; ubiquitin protein ligase binding","chromatin; cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus; PML body","Metabolism","PPARG coactivator 1 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=10891","10891","19017",null,null,"397013",null,"Q9UBK2","O70343","A0A8I5Y905","A0A8I3MZ45","Q865B6","A0A1D5QEZ6","GO:0000785; GO:0005737; GO:0043231; GO:0005654; GO:0005634; GO:0016605","GO:0031490; GO:0003677; GO:0140297; GO:0016922; GO:0030374; GO:0003676; GO:0005515; GO:0003723; GO:0061629; GO:0043565; GO:0003713; GO:0003712; GO:0031625","GO:0060612; GO:0050873; GO:0001678; GO:0045333; GO:0034599; GO:0032922; GO:0007586; GO:0097009; GO:0019395; GO:0006094; GO:0007005; GO:0006397; GO:0043524; GO:1901215; GO:0048662; GO:0051402; GO:2001171; GO:1901857; GO:0120162; GO:0051091; GO:0045893; GO:0046321; GO:0010628; GO:0045722; GO:0035066; GO:1901860; GO:0010822; GO:1901863; GO:0045944; GO:0050821; GO:0065003; GO:0042752; GO:0006355; GO:0022904; GO:0002021; GO:0014850; GO:0042594; GO:0048511; GO:0008380; GO:0001659; GO:0006367","PTHR15528:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9237|UniProtKB=Q9UBK2"]
["P-Glycoprotein (MDR1, ABCB1)",null,"ABCB1","170","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0456",".CCP., .CCY., .CP., .DRR., .OP., .OT.",null,"ATP-DEPENDENT TRANSLOCASE ABCB1","carboxylic acid transmembrane transport; ceramide translocation; export across plasma membrane; G2/M transition of mitotic cell cycle; lipid transport; phospholipid translocation; positive regulation of anion channel activity; regulation of chloride transport; regulation of response to osmotic stress; response to xenobiotic stimulus; stem cell proliferation; terpenoid transport; transepithelial transport; transmembrane transport; transport across blood-brain barrier; xenobiotic detoxification by transmembrane export across the plasma membrane; xenobiotic metabolic process; xenobiotic transport across blood-brain barrier","ABC-type transporter activity; ABC-type xenobiotic transporter activity; ATP binding; ATP hydrolysis activity; ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; carboxylic acid transmembrane transporter activity; ceramide floppase activity; efflux transmembrane transporter activity; floppase activity; nucleotide binding; phosphatidylcholine floppase activity; phosphatidylethanolamine flippase activity; protein binding; transmembrane transporter activity; ubiquitin protein ligase binding; xenobiotic transmembrane transporter activity","apical plasma membrane; cell surface; cytoplasm; external side of apical plasma membrane; extracellular exosome; membrane; nucleoplasm; plasma membrane","Metabolism","ATP binding cassette subfamily B member 1","http://www.ncbi.nlm.nih.gov/gene/?term=5243","5243","18671",null,null,null,null,"P08183","P21447",null,"A0A8I3N2I4","A0A287ABL3",null,"GO:0016324; GO:0009986; GO:0005737; GO:0098591; GO:0070062; GO:0016020; GO:0005654; GO:0005886","GO:0140359; GO:0008559; GO:0005524; GO:0016887; GO:0140326; GO:0042626; GO:0046943; GO:0099038; GO:0015562; GO:0140328; GO:0000166; GO:0090554; GO:0090555; GO:0005515; GO:0022857; GO:0031625; GO:0042910","GO:1905039; GO:0099040; GO:0140115; GO:0000086; GO:0006869; GO:0045332; GO:1901529; GO:2001225; GO:0047484; GO:0009410; GO:0072089; GO:0046865; GO:0070633; GO:0055085; GO:0150104; GO:1990961; GO:0006805; GO:1990962","PTHR24221:SF251","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=40|UniProtKB=P08183"]
["PGRMC1",null,"PGRMC1","28","rb",null,6,2,7,7,6,8,"# 1767",null,null,null,"associative learning; axon guidance; memory; modification of synaptic structure; negative regulation of synapse organization; positive regulation of protein localization to plasma membrane","heme binding; protein binding","cell body; membrane; mitochondrial outer membrane; neuron projection; neuronal cell body; synapse",null,"progesterone receptor membrane component 1","http://www.ncbi.nlm.nih.gov/gene/?term=10857","10857",null,null,null,null,null,"Q6IB11",null,null,null,null,null,"GO:0044297; GO:0016020; GO:0005741; GO:0043005; GO:0043025; GO:0045202","GO:0020037; GO:0005515","GO:0008306; GO:0007411; GO:0007613; GO:0099563; GO:1905809; GO:1903078"]
["PHGDH",null,"PHGDH","57","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2832",".CCP., .CCY., .OP., .OT., .TRASR.","Serine glycine biosynthesis","D-3-PHOSPHOGLYCERATE DEHYDROGENASE","amino acid biosynthetic process; brain development; electron transport chain; G1 to G0 transition; gamma-aminobutyric acid metabolic process; glial cell development; glutamine metabolic process; glycine metabolic process; L-serine biosynthetic process; L-serine metabolic process; neural tube development; neurogenesis; neuron projection development; regulation of gene expression; spinal cord development; taurine metabolic process; threonine metabolic process","electron transfer activity; L-malate dehydrogenase activity; NAD binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; phosphoglycerate dehydrogenase activity","cytosol; extracellular exosome",null,"phosphoglycerate dehydrogenase","http://www.ncbi.nlm.nih.gov/gene/?term=26227","26227","236539",null,"607890","100144529",null,"O43175","Q61753","A0A8L2UMI0","A0A8I3N4A3","A5GFY8","F7DRL6","GO:0005829; GO:0070062","GO:0009055; GO:0030060; GO:0051287; GO:0016491; GO:0016616; GO:0004617","GO:0008652; GO:0007420; GO:0022900; GO:0070314; GO:0009448; GO:0021782; GO:0006541; GO:0006544; GO:0006564; GO:0006563; GO:0021915; GO:0022008; GO:0031175; GO:0010468; GO:0021510; GO:0019530; GO:0006566","PTHR42938:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8923|UniProtKB=O43175","P02776"]
["Phospholamban",null,"PLN","24, 12","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2216",".cAMP., .CSP., .DEV., .GPCR., .GPROT., .NOTCH.",null,"CARDIAC PHOSPHOLAMBAN","acrosome assembly; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; blood circulation; cardiac muscle tissue development; cellular calcium ion homeostasis; muscle cell cellular homeostasis; negative regulation of ATPase-coupled calcium transmembrane transporter activity; negative regulation of ATP-dependent activity; negative regulation of calcium ion binding; negative regulation of calcium ion import; negative regulation of calcium ion import into sarcoplasmic reticulum; negative regulation of calcium ion transmembrane transporter activity; negative regulation of calcium ion transport; negative regulation of catalytic activity; negative regulation of heart contraction; negative regulation of heart rate; Notch signaling pathway; regulation of ATPase-coupled calcium transmembrane transporter activity; regulation of calcium ion import; regulation of calcium ion transport; regulation of cardiac muscle cell contraction; regulation of cardiac muscle cell membrane potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cytosolic calcium ion concentration; regulation of heart contraction; regulation of relaxation of cardiac muscle; regulation of relaxation of muscle; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; regulation of the force of heart contraction; regulation of the force of heart contraction by cardiac conduction; relaxation of cardiac muscle","ATPase binding; ATPase inhibitor activity; enzyme inhibitor activity; identical protein binding; protein binding; protein homodimerization activity","calcium ion-transporting ATPase complex; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial membrane; mitochondrion; perinuclear region of cytoplasm; sarcoplasmic reticulum; sarcoplasmic reticulum membrane",null,"phospholamban","http://www.ncbi.nlm.nih.gov/gene/?term=5350","5350","18821",null,null,null,null,"P26678","P61014",null,null,null,null,"GO:0090534; GO:0005783; GO:0005789; GO:0016020; GO:0031966; GO:0005739; GO:0048471; GO:0016529; GO:0033017","GO:0051117; GO:0042030; GO:0004857; GO:0042802; GO:0005515; GO:0042803","GO:0001675; GO:0086023; GO:0008015; GO:0048738; GO:0006874; GO:0046716; GO:1901895; GO:0032780; GO:1901877; GO:0090281; GO:1902081; GO:1901020; GO:0051926; GO:0043086; GO:0045822; GO:0010459; GO:0007219; GO:1901894; GO:0090279; GO:0051924; GO:0086004; GO:0086036; GO:0010881; GO:0051480; GO:0008016; GO:1901897; GO:1901077; GO:0010880; GO:0060314; GO:0002026; GO:0086092; GO:0055119","PTHR21194:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9080|UniProtKB=P26678"]
["Phospholamban - phospho","Ser16/Thr17","PLN","24, 12, 6","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2202",".cAMP., .CSP., .DEV., .GPCR., .GPROT., .NOTCH.",null,"CARDIAC PHOSPHOLAMBAN","acrosome assembly; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; blood circulation; cardiac muscle tissue development; cellular calcium ion homeostasis; muscle cell cellular homeostasis; negative regulation of ATPase-coupled calcium transmembrane transporter activity; negative regulation of ATP-dependent activity; negative regulation of calcium ion binding; negative regulation of calcium ion import; negative regulation of calcium ion import into sarcoplasmic reticulum; negative regulation of calcium ion transmembrane transporter activity; negative regulation of calcium ion transport; negative regulation of catalytic activity; negative regulation of heart contraction; negative regulation of heart rate; Notch signaling pathway; regulation of ATPase-coupled calcium transmembrane transporter activity; regulation of calcium ion import; regulation of calcium ion transport; regulation of cardiac muscle cell contraction; regulation of cardiac muscle cell membrane potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cytosolic calcium ion concentration; regulation of heart contraction; regulation of relaxation of cardiac muscle; regulation of relaxation of muscle; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; regulation of the force of heart contraction; regulation of the force of heart contraction by cardiac conduction; relaxation of cardiac muscle","ATPase binding; ATPase inhibitor activity; enzyme inhibitor activity; identical protein binding; protein binding; protein homodimerization activity","calcium ion-transporting ATPase complex; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial membrane; mitochondrion; perinuclear region of cytoplasm; sarcoplasmic reticulum; sarcoplasmic reticulum membrane",null,"phospholamban","http://www.ncbi.nlm.nih.gov/gene/?term=5350","5350","18821",null,null,null,null,"P26678","P61014",null,null,null,null,"GO:0090534; GO:0005783; GO:0005789; GO:0016020; GO:0031966; GO:0005739; GO:0048471; GO:0016529; GO:0033017","GO:0051117; GO:0042030; GO:0004857; GO:0042802; GO:0005515; GO:0042803","GO:0001675; GO:0086023; GO:0008015; GO:0048738; GO:0006874; GO:0046716; GO:1901895; GO:0032780; GO:1901877; GO:0090281; GO:1902081; GO:1901020; GO:0051926; GO:0043086; GO:0045822; GO:0010459; GO:0007219; GO:1901894; GO:0090279; GO:0051924; GO:0086004; GO:0086036; GO:0010881; GO:0051480; GO:0008016; GO:1901897; GO:1901077; GO:0010880; GO:0060314; GO:0002026; GO:0086092; GO:0055119","PTHR21194:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9080|UniProtKB=P26678"]
["PI3 Kinase C2 alpha",null,"PIK3C2A","190","rb",null,6,2,"n/a","n/a","n/a","n/a","# 1869",".ANG., .APH., .CANCER., .CD., .CSP., .EGFR., .ENDO., .FGFR., .HIF., .INS., .INT., .MIG., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .SREME., .ST., .VEGFS.","p53 pathway; Axon guidance mediated by netrin; VEGF signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; FGF signaling pathway; Integrin signalling pathway; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; Endothelin signaling pathway; p53 pathway feedback loops 2","PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA","cell migration; clathrin coat assembly; endocytosis; epidermal growth factor receptor signaling pathway; exocytosis; insulin receptor signaling pathway; lipid metabolic process; membrane organization; phosphatidylinositol 3-kinase signaling; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of autophagy; positive regulation of cell migration involved in sprouting angiogenesis; vascular associated smooth muscle contraction","1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; clathrin binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol binding; phosphatidylinositol kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; transferase activity","clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytosol; extracellular exosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; nucleoplasm; nucleus; phosphatidylinositol 3-kinase complex; plasma membrane; trans-Golgi network; vesicle","Intracellular trafficing","phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5286","5286",null,"361632",null,null,null,"O00443","A0A0U1RNH9","D3ZTF6","A0A8I3PTV0","I3LLX2","A0A1D5QZF9","GO:0030136; GO:0005737; GO:0031410; GO:0005829; GO:0070062; GO:0005794; GO:0043231; GO:0016020; GO:0005654; GO:0005634; GO:0005942; GO:0005886; GO:0005802; GO:0031982","GO:0016303; GO:0035005; GO:0005524; GO:0030276; GO:0016301; GO:0000166; GO:0035004; GO:0035091; GO:0052742; GO:0052812; GO:0046934; GO:0016740","GO:0016477; GO:0048268; GO:0006897; GO:0007173; GO:0006887; GO:0008286; GO:0006629; GO:0061024; GO:0014065; GO:0006661; GO:0046854; GO:0036092; GO:0048015; GO:0016310; GO:0048008; GO:0010508; GO:0090050; GO:0014829","PTHR10048:SF28","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8971|UniProtKB=O00443","P00059; P00009; P00056; P00033; P00021; P00034; P00005; P00018; P00030; P00019; P04398"]
["PI3 Kinase p101",null,"PIK3R5","101","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2376",".CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .EGFR., .ENDO., .GPCR., .GPROT., .IMU., .IMUR., .INS., .MAPK., .OP., .OPA., .OT., .P53S., .PDGF., .PI3K., .PLAT., .RTK., .SREME.","p53 pathway; Axon guidance mediated by netrin; Insulin/IGF pathway-protein kinase B signaling cascade; PDGF signaling pathway; EGF receptor signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2","PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5","G protein-coupled receptor signaling pathway; immune response; phosphatidylinositol 3-kinase signaling; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; regulation of phosphatidylinositol 3-kinase activity","1-phosphatidylinositol-3-kinase regulator activity; G-protein beta/gamma-subunit complex binding","centriolar satellite; cytoplasm; cytosol; membrane; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; phosphatidylinositol 3-kinase complex, class IB; plasma membrane",null,"phosphoinositide-3-kinase regulatory subunit 5","http://www.ncbi.nlm.nih.gov/gene/?term=23533","23533","320207","497931","612805",null,null,"Q8WYR1","Q5SW28","D4A4I3","A0A8P0NIS4","A0A286ZR76","F6VTR8","GO:0034451; GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:0005942; GO:0005943; GO:0005944; GO:0005886","GO:0046935; GO:0031683","GO:0007186; GO:0006955; GO:0014065; GO:0043406; GO:0051897; GO:0043551","PTHR15593:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=30035|UniProtKB=Q8WYR1","P00059; P00009; P00033; P00047; P00018; P00019; P00048; P04398"]
["PI3 Kinase p110 alpha",null,"PIK3CA","110","rb",null,2,7,7,8,2.1,2.1,"# 3116",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INFM., .INS., .INT., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","T cell activation; p53 pathway; Axon guidance mediated by netrin; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","actin cytoskeleton organization; adipose tissue development; angiogenesis; anoikis; cardiac muscle cell contraction; cardiac muscle contraction; cell migration; cellular response to glucose stimulus; cellular response to hydrostatic pressure; endothelial cell migration; energy homeostasis; epidermal growth factor receptor signaling pathway; glucose metabolic process; hypomethylation of CpG island; insulin receptor signaling pathway; insulin receptor signaling pathway via phosphatidylinositol 3-kinase; insulin-like growth factor receptor signaling pathway; lipid metabolic process; liver development; negative regulation of actin filament depolymerization; negative regulation of anoikis; negative regulation of fibroblast apoptotic process; negative regulation of gene expression; negative regulation of macroautophagy; negative regulation of neuron apoptotic process; phagocytosis; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet activation; positive regulation of lamellipodium assembly; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell proliferation; positive regulation of TOR signaling; protein kinase B signaling; regulation of actin filament organization; regulation of cellular respiration; regulation of gene expression; regulation of genetic imprinting; regulation of multicellular organism growth; regulation of protein phosphorylation; relaxation of cardiac muscle; response to activity; response to butyrate; response to dexamethasone; response to leucine; response to muscle inactivity; response to muscle stretch; T cell costimulation; T cell receptor signaling pathway; vascular endothelial growth factor signaling pathway; vasculature development","1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; insulin receptor substrate binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein kinase activator activity; protein serine kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; intercalated disc; lamellipodium; membrane; perinuclear region of cytoplasm; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; phosphatidylinositol 3-kinase complex, class IB; plasma membrane","Akt signaling / metabolism","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5290","5290","18706","170911","488084",null,"709959","P42336","P42337","A0A0G2K344","A0A5F4C2B1","A0A286ZVK7","H9FVU5","GO:0005737; GO:0005829; GO:0014704; GO:0030027; GO:0016020; GO:0048471; GO:0005942; GO:0005943; GO:0005944; GO:0005886","GO:0016303; GO:0035005; GO:0005524; GO:0043560; GO:0016301; GO:0000166; GO:0035004; GO:0052742; GO:0052812; GO:0046934; GO:0005515; GO:0030295; GO:0106310; GO:0043539; GO:0004674; GO:0016740","GO:0030036; GO:0060612; GO:0001525; GO:0043276; GO:0086003; GO:0060048; GO:0016477; GO:0071333; GO:0071464; GO:0043542; GO:0097009; GO:0007173; GO:0006006; GO:0044029; GO:0008286; GO:0038028; GO:0048009; GO:0006629; GO:0001889; GO:0030835; GO:2000811; GO:2000270; GO:0010629; GO:0016242; GO:0043524; GO:0006909; GO:0014065; GO:0046854; GO:0036092; GO:0048015; GO:0016310; GO:0030168; GO:0010592; GO:0033138; GO:0051897; GO:0048661; GO:0032008; GO:0043491; GO:0110053; GO:0043457; GO:0010468; GO:2000653; GO:0040014; GO:0001932; GO:0055119; GO:0014823; GO:1903544; GO:0071548; GO:0043201; GO:0014870; GO:0035994; GO:0031295; GO:0050852; GO:0038084; GO:0001944","PTHR10048:SF107","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8975|UniProtKB=P42336","P00053; P00059; P00009; P00010; P00056; P00036; P00033; P00021; P04393; P00034; P00047; P00005; P00018; P00030; P00031; P00019; P00048; P04398; P00006"]
["PI3 Kinase p110 beta",null,"PIK3CB","110","rb",null,2,7,7,2,1,1,"# 1049",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .DI., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; Axon guidance mediated by netrin; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","angiogenesis involved in wound healing; autophagy; cell adhesion; cell migration; cellular calcium ion homeostasis; chemotaxis; embryonic cleavage; endocytosis; endothelial cell proliferation; G protein-coupled receptor signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; lipid metabolic process; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; negative regulation of MAP kinase activity; negative regulation of protein kinase B signaling; negative regulation of sprouting angiogenesis; negative regulation of vascular endothelial growth factor signaling pathway; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet activation; platelet aggregation; positive regulation of autophagy; positive regulation of endothelial cell migration; positive regulation of gene expression; positive regulation of neutrophil apoptotic process; positive regulation of nitric-oxide synthase activity; positive regulation of protein kinase B signaling; positive regulation of Rac protein signal transduction; regulation of cell-matrix adhesion; regulation of clathrin-dependent endocytosis; response to ischemia; signal transduction; sphingosine-1-phosphate receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; insulin receptor substrate binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein serine kinase activity; transferase activity","cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; midbody; nucleolus; nucleoplasm; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; plasma membrane","Akt signaling / metabolism","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta","http://www.ncbi.nlm.nih.gov/gene/?term=5291","5291","74769",null,null,null,null,"P42338","Q8BTI9","A0A8I6GH69","A0A8I3PWT3","A0A287B5R5","A0A5F7ZR11","GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0030496; GO:0005730; GO:0005654; GO:0005634; GO:0005942; GO:0005943; GO:0005886","GO:0016303; GO:0035005; GO:0005524; GO:0043560; GO:0016301; GO:0000166; GO:0035004; GO:0052742; GO:0052812; GO:0046934; GO:0005515; GO:0106310; GO:0016740","GO:0060055; GO:0006914; GO:0007155; GO:0016477; GO:0006874; GO:0006935; GO:0040016; GO:0006897; GO:0001935; GO:0007186; GO:0007156; GO:0006629; GO:1903298; GO:0043407; GO:0051898; GO:1903671; GO:1900747; GO:0014065; GO:0046854; GO:0036092; GO:0048015; GO:0016310; GO:0030168; GO:0070527; GO:0010508; GO:0010595; GO:0010628; GO:0033031; GO:0051000; GO:0051897; GO:0035022; GO:0001952; GO:2000369; GO:0002931; GO:0007165; GO:0003376; GO:0007169","PTHR10048:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8976|UniProtKB=P42338","P06959; P00053; P00059; P00009; P00010; P00056; P00036; P00033; P00021; P04393; P00034; P00047; P00005; P00018; P00030; P00031; P00019; P00048; P04398; P00006"]
["PI3 Kinase p110 beta",null,"PIK3CB","110","ms",null,2,8,"n/a","n/a","n/a","n/a","# 2563",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; Axon guidance mediated by netrin; B cell activation; VEGF signaling pathway; Interleukin signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM","angiogenesis involved in wound healing; autophagy; cell adhesion; cell migration; cellular calcium ion homeostasis; chemotaxis; embryonic cleavage; endocytosis; endothelial cell proliferation; G protein-coupled receptor signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; lipid metabolic process; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; negative regulation of MAP kinase activity; negative regulation of protein kinase B signaling; negative regulation of sprouting angiogenesis; negative regulation of vascular endothelial growth factor signaling pathway; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet activation; platelet aggregation; positive regulation of autophagy; positive regulation of endothelial cell migration; positive regulation of gene expression; positive regulation of neutrophil apoptotic process; positive regulation of nitric-oxide synthase activity; positive regulation of protein kinase B signaling; positive regulation of Rac protein signal transduction; regulation of cell-matrix adhesion; regulation of clathrin-dependent endocytosis; response to ischemia; signal transduction; sphingosine-1-phosphate receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; insulin receptor substrate binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein serine kinase activity; transferase activity","cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; midbody; nucleolus; nucleoplasm; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; plasma membrane","Akt signaling / metabolism","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta","http://www.ncbi.nlm.nih.gov/gene/?term=5291","5291","74769",null,null,null,null,"P42338","Q8BTI9","A0A8I6GH69","A0A8I3PWT3","A0A287B5R5","A0A5F7ZR11","GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0030496; GO:0005730; GO:0005654; GO:0005634; GO:0005942; GO:0005943; GO:0005886","GO:0016303; GO:0035005; GO:0005524; GO:0043560; GO:0016301; GO:0000166; GO:0035004; GO:0052742; GO:0052812; GO:0046934; GO:0005515; GO:0106310; GO:0016740","GO:0060055; GO:0006914; GO:0007155; GO:0016477; GO:0006874; GO:0006935; GO:0040016; GO:0006897; GO:0001935; GO:0007186; GO:0007156; GO:0006629; GO:1903298; GO:0043407; GO:0051898; GO:1903671; GO:1900747; GO:0014065; GO:0046854; GO:0036092; GO:0048015; GO:0016310; GO:0030168; GO:0070527; GO:0010508; GO:0010595; GO:0010628; GO:0033031; GO:0051000; GO:0051897; GO:0035022; GO:0001952; GO:2000369; GO:0002931; GO:0007165; GO:0003376; GO:0007169","PTHR10048:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8976|UniProtKB=P42338","P06959; P00053; P00059; P00009; P00010; P00056; P00036; P00033; P00021; P04393; P00034; P00047; P00005; P00018; P00030; P00031; P00019; P00048; P04398; P00006"]
["PI3 Kinase p110 delta",null,"PIK3CD","110","rb",null,2,6,"n/a","n/a","n/a","n/a","# 1601",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","T cell activation; p53 pathway; Axon guidance mediated by netrin; B cell activation; VEGF signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","adaptive immune response; B cell activation; B cell chemotaxis; B cell differentiation; B cell receptor signaling pathway; cell differentiation; cell migration; chemotaxis; immune response; immune system process; inflammatory response; innate immune response; lipid metabolic process; mast cell chemotaxis; mast cell degranulation; mast cell differentiation; natural killer cell activation; natural killer cell chemotaxis; natural killer cell differentiation; neutrophil chemotaxis; neutrophil extravasation; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; positive regulation of cytokine production; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial tube formation; positive regulation of gene expression; positive regulation of neutrophil apoptotic process; positive regulation of protein kinase B signaling; protein phosphorylation; respiratory burst involved in defense response; signal transduction; T cell activation; T cell chemotaxis; T cell differentiation; T cell receptor signaling pathway","1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; transferase activity","cytoplasm; cytosol; membrane; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; plasma membrane","Akt signaling / metabolism","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta","http://www.ncbi.nlm.nih.gov/gene/?term=5293","5293","18707",null,"489644","100518131",null,"O00329","O35904","A0A8I5Y949","A0A8I3Q525","A0A5K1UPW2","A0A5F8AQY8","GO:0005737; GO:0005829; GO:0016020; GO:0005942; GO:0005943; GO:0005886","GO:0016303; GO:0035005; GO:0005524; GO:0016301; GO:0000166; GO:0035004; GO:0052742; GO:0052812; GO:0046934; GO:0005515; GO:0016740","GO:0002250; GO:0042113; GO:0035754; GO:0030183; GO:0050853; GO:0030154; GO:0016477; GO:0006935; GO:0006955; GO:0002376; GO:0006954; GO:0045087; GO:0006629; GO:0002551; GO:0043303; GO:0060374; GO:0030101; GO:0035747; GO:0001779; GO:0030593; GO:0072672; GO:0014065; GO:0046854; GO:0036092; GO:0048015; GO:0016310; GO:0045766; GO:0030335; GO:0038089; GO:0001819; GO:0010595; GO:0001938; GO:1905278; GO:0010628; GO:0033031; GO:0051897; GO:0006468; GO:0002679; GO:0007165; GO:0042110; GO:0010818; GO:0030217; GO:0050852","PTHR10048:SF35","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8977|UniProtKB=O00329","P00053; P00059; P00009; P00010; P00056; P00033; P00021; P04393; P00034; P00047; P00005; P00018; P00030; P00031; P00019; P04398; P00006"]
["PI3 Kinase p110 gamma",null,"PIK3CG","110","ms",null,1,4,"n/a","n/a","n/a","n/a","# 1051",".ANG., .APO., .BCR., .cAMP., .CANCER., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .HIF., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P53S., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .VEGFS.","T cell activation; p53 pathway; Axon guidance mediated by netrin; B cell activation; VEGF signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM","adaptive immune response; angiogenesis; cell migration; cellular response to cAMP; chemotaxis; dendritic cell chemotaxis; endocytosis; G protein-coupled receptor signaling pathway; hepatocyte apoptotic process; immune response; immune system process; inflammatory response; innate immune response; lipid metabolic process; mast cell degranulation; natural killer cell chemotaxis; negative regulation of cardiac muscle contraction; negative regulation of fibroblast apoptotic process; negative regulation of triglyceride catabolic process; neutrophil chemotaxis; neutrophil extravasation; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet aggregation; positive regulation of acute inflammatory response; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of cytosolic calcium ion concentration; positive regulation of endothelial cell migration; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; positive regulation of Rac protein signal transduction; protein phosphorylation; regulation of calcium ion transmembrane transport; regulation of cell adhesion mediated by integrin; regulation of protein phosphorylation; respiratory burst involved in defense response; secretory granule localization; sphingosine-1-phosphate receptor signaling pathway; T cell activation; T cell chemotaxis; T cell proliferation","1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; ephrin receptor binding; identical protein binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; membrane; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; phosphatidylinositol 3-kinase complex, class IB; plasma membrane","Akt signaling / metabolism","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma","http://www.ncbi.nlm.nih.gov/gene/?term=5294","5294","30955",null,null,null,"698857","P48736","Q9JHG7","A0A8I6AKZ7","A0A8P0N6P9",null,"F6W7C8","GO:0005737; GO:0005829; GO:0016020; GO:0005942; GO:0005943; GO:0005944; GO:0005886","GO:0016303; GO:0035005; GO:0005524; GO:0046875; GO:0042802; GO:0016301; GO:0000166; GO:0035004; GO:0052742; GO:0052812; GO:0046934; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0002250; GO:0001525; GO:0016477; GO:0071320; GO:0006935; GO:0002407; GO:0006897; GO:0007186; GO:0097284; GO:0006955; GO:0002376; GO:0006954; GO:0045087; GO:0006629; GO:0043303; GO:0035747; GO:0055118; GO:2000270; GO:0010897; GO:0030593; GO:0072672; GO:0014065; GO:0046854; GO:0036092; GO:0048015; GO:0016310; GO:0070527; GO:0002675; GO:0043085; GO:0001819; GO:0007204; GO:0010595; GO:0043406; GO:0051897; GO:0035022; GO:0006468; GO:1903169; GO:0033628; GO:0001932; GO:0002679; GO:0032252; GO:0003376; GO:0042110; GO:0010818; GO:0042098","PTHR10048:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8978|UniProtKB=P48736","P00053; P00059; P00009; P00010; P00056; P00033; P00021; P04393; P00034; P00047; P00005; P00018; P00030; P00031; P00019; P04398; P00006"]
["PI3 Kinase p110 gamma",null,"PIK3CG","110","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2377",".ANG., .APO., .BCR., .cAMP., .CANCER., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .HIF., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P53S., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .VEGFS.","T cell activation; p53 pathway; Axon guidance mediated by netrin; B cell activation; VEGF signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; p53 pathway feedback loops 2; Apoptosis signaling pathway","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM","adaptive immune response; angiogenesis; cell migration; cellular response to cAMP; chemotaxis; dendritic cell chemotaxis; endocytosis; G protein-coupled receptor signaling pathway; hepatocyte apoptotic process; immune response; immune system process; inflammatory response; innate immune response; lipid metabolic process; mast cell degranulation; natural killer cell chemotaxis; negative regulation of cardiac muscle contraction; negative regulation of fibroblast apoptotic process; negative regulation of triglyceride catabolic process; neutrophil chemotaxis; neutrophil extravasation; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; platelet aggregation; positive regulation of acute inflammatory response; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of cytosolic calcium ion concentration; positive regulation of endothelial cell migration; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; positive regulation of Rac protein signal transduction; protein phosphorylation; regulation of calcium ion transmembrane transport; regulation of cell adhesion mediated by integrin; regulation of protein phosphorylation; respiratory burst involved in defense response; secretory granule localization; sphingosine-1-phosphate receptor signaling pathway; T cell activation; T cell chemotaxis; T cell proliferation","1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; ephrin receptor binding; identical protein binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; membrane; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; phosphatidylinositol 3-kinase complex, class IB; plasma membrane","Akt signaling / metabolism","phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma","http://www.ncbi.nlm.nih.gov/gene/?term=5294","5294","30955",null,null,null,"698857","P48736","Q9JHG7","A0A8I6AKZ7","A0A8P0N6P9",null,"F6W7C8","GO:0005737; GO:0005829; GO:0016020; GO:0005942; GO:0005943; GO:0005944; GO:0005886","GO:0016303; GO:0035005; GO:0005524; GO:0046875; GO:0042802; GO:0016301; GO:0000166; GO:0035004; GO:0052742; GO:0052812; GO:0046934; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0002250; GO:0001525; GO:0016477; GO:0071320; GO:0006935; GO:0002407; GO:0006897; GO:0007186; GO:0097284; GO:0006955; GO:0002376; GO:0006954; GO:0045087; GO:0006629; GO:0043303; GO:0035747; GO:0055118; GO:2000270; GO:0010897; GO:0030593; GO:0072672; GO:0014065; GO:0046854; GO:0036092; GO:0048015; GO:0016310; GO:0070527; GO:0002675; GO:0043085; GO:0001819; GO:0007204; GO:0010595; GO:0043406; GO:0051897; GO:0035022; GO:0006468; GO:1903169; GO:0033628; GO:0001932; GO:0002679; GO:0032252; GO:0003376; GO:0042110; GO:0010818; GO:0042098","PTHR10048:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8978|UniProtKB=P48736","P00053; P00059; P00009; P00010; P00056; P00033; P00021; P04393; P00034; P00047; P00005; P00018; P00030; P00031; P00019; P04398; P00006"]
["PI3 Kinase p85",null,"PIK3R1","85","rb",null,6,2,2,2,2,2,"# 2794",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CML., .CRC., .CSP., .DDR., .DI., .EGFR., .EMC., .ENDO., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMU., .IMUF., .IMUR., .INS., .INT., .LMIG., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; Axon guidance mediated by netrin; VEGF signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Hypoxia response via HIF activation; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA","B cell differentiation; cellular glucose homeostasis; cellular response to insulin stimulus; cellular response to UV; extrinsic apoptotic signaling pathway via death domain receptors; growth hormone receptor signaling pathway; immune response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; myeloid leukocyte migration; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of osteoclast differentiation; negative regulation of stress fiber assembly; osteoclast differentiation; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphate biosynthetic process; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of filopodium assembly; positive regulation of focal adhesion disassembly; positive regulation of glucose import; positive regulation of lamellipodium assembly; positive regulation of leukocyte migration; positive regulation of protein import into nucleus; positive regulation of protein localization to plasma membrane; positive regulation of RNA splicing; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; protein import into nucleus; protein phosphorylation; protein stabilization; protein transport; regulation of insulin receptor signaling pathway; regulation of phosphatidylinositol 3-kinase activity; regulation of protein localization to plasma membrane; regulation of stress fiber assembly; response to endoplasmic reticulum stress; signal transduction; substrate adhesion-dependent cell spreading; T cell differentiation; transcription by RNA polymerase II","1-phosphatidylinositol-3-kinase regulator activity; ErbB-3 class receptor binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor receptor binding; neurotrophin TRKA receptor binding; phosphatidylinositol 3-kinase binding; phosphatidylinositol 3-kinase regulator activity; phosphatidylinositol 3-kinase regulatory subunit binding; phosphotyrosine residue binding; protein binding; protein heterodimerization activity; protein phosphatase binding; protein serine/threonine kinase activator activity; transmembrane receptor protein tyrosine kinase adaptor activity","cell-cell junction; cis-Golgi network; cytoplasm; cytosol; membrane; nucleus; perinuclear endoplasmic reticulum membrane; perinuclear region of cytoplasm; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; plasma membrane; protein-containing complex","Akt signaling / metabolism","phosphoinositide-3-kinase regulatory subunit 1","http://www.ncbi.nlm.nih.gov/gene/?term=5295","5295","18708","25513","487235",null,"698996","P27986","P26450","F1LNG5","A0A8I3N971","A0A287AIC1","F7BZK1","GO:0005911; GO:0005801; GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:1990578; GO:0048471; GO:0005942; GO:0005943; GO:0005886; GO:0032991","GO:0046935; GO:0043125; GO:0043559; GO:0005158; GO:0043560; GO:0005159; GO:0005168; GO:0043548; GO:0035014; GO:0036312; GO:0001784; GO:0005515; GO:0046982; GO:0019903; GO:0043539; GO:0005068","GO:0030183; GO:0001678; GO:0032869; GO:0034644; GO:0008625; GO:0060396; GO:0006955; GO:0008286; GO:0048009; GO:0008630; GO:0097529; GO:0043066; GO:0007162; GO:0001953; GO:0045671; GO:0051497; GO:0030316; GO:0014065; GO:0046854; GO:1900103; GO:0051491; GO:0120183; GO:0046326; GO:0010592; GO:0002687; GO:0042307; GO:1903078; GO:0033120; GO:0045944; GO:0032760; GO:0006606; GO:0006468; GO:0050821; GO:0015031; GO:0046626; GO:0043551; GO:1903076; GO:0051492; GO:0034976; GO:0007165; GO:0034446; GO:0030217; GO:0006366","PTHR10155:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8979|UniProtKB=P27986","P06959; P00053; P00059; P00009; P00056; P00033; P06664; P00034; P00047; P00005; P00030; P00019; P00048; P04398"]
["PI3 Kinase p85 alpha",null,"PIK3R1","85","rb",null,2,2,1,1,1.1000000000000001,1.1000000000000001,"# 1967",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CML., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMU., .IMUF., .IMUR., .INS., .INT., .LMIG., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","CCKR signaling map; T cell activation; p53 pathway; Axon guidance mediated by netrin; VEGF signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Hypoxia response via HIF activation; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA","B cell differentiation; cellular glucose homeostasis; cellular response to insulin stimulus; cellular response to UV; extrinsic apoptotic signaling pathway via death domain receptors; growth hormone receptor signaling pathway; immune response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; myeloid leukocyte migration; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of osteoclast differentiation; negative regulation of stress fiber assembly; osteoclast differentiation; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphate biosynthetic process; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of filopodium assembly; positive regulation of focal adhesion disassembly; positive regulation of glucose import; positive regulation of lamellipodium assembly; positive regulation of leukocyte migration; positive regulation of protein import into nucleus; positive regulation of protein localization to plasma membrane; positive regulation of RNA splicing; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; protein import into nucleus; protein phosphorylation; protein stabilization; protein transport; regulation of insulin receptor signaling pathway; regulation of phosphatidylinositol 3-kinase activity; regulation of protein localization to plasma membrane; regulation of stress fiber assembly; response to endoplasmic reticulum stress; signal transduction; substrate adhesion-dependent cell spreading; T cell differentiation; transcription by RNA polymerase II","1-phosphatidylinositol-3-kinase regulator activity; ErbB-3 class receptor binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor receptor binding; neurotrophin TRKA receptor binding; phosphatidylinositol 3-kinase binding; phosphatidylinositol 3-kinase regulator activity; phosphatidylinositol 3-kinase regulatory subunit binding; phosphotyrosine residue binding; protein binding; protein heterodimerization activity; protein phosphatase binding; protein serine/threonine kinase activator activity; transmembrane receptor protein tyrosine kinase adaptor activity","cell-cell junction; cis-Golgi network; cytoplasm; cytosol; membrane; nucleus; perinuclear endoplasmic reticulum membrane; perinuclear region of cytoplasm; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; plasma membrane; protein-containing complex","Akt signaling / metabolism","phosphoinositide-3-kinase regulatory subunit 1","http://www.ncbi.nlm.nih.gov/gene/?term=5295","5295","18708","25513","487235",null,"698996","P27986","P26450","F1LNG5","A0A8I3N971","A0A287AIC1","F7BZK1","GO:0005911; GO:0005801; GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:1990578; GO:0048471; GO:0005942; GO:0005943; GO:0005886; GO:0032991","GO:0046935; GO:0043125; GO:0043559; GO:0005158; GO:0043560; GO:0005159; GO:0005168; GO:0043548; GO:0035014; GO:0036312; GO:0001784; GO:0005515; GO:0046982; GO:0019903; GO:0043539; GO:0005068","GO:0030183; GO:0001678; GO:0032869; GO:0034644; GO:0008625; GO:0060396; GO:0006955; GO:0008286; GO:0048009; GO:0008630; GO:0097529; GO:0043066; GO:0007162; GO:0001953; GO:0045671; GO:0051497; GO:0030316; GO:0014065; GO:0046854; GO:1900103; GO:0051491; GO:0120183; GO:0046326; GO:0010592; GO:0002687; GO:0042307; GO:1903078; GO:0033120; GO:0045944; GO:0032760; GO:0006606; GO:0006468; GO:0050821; GO:0015031; GO:0046626; GO:0043551; GO:1903076; GO:0051492; GO:0034976; GO:0007165; GO:0034446; GO:0030217; GO:0006366","PTHR10155:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8979|UniProtKB=P27986","P06959; P00053; P00059; P00009; P00056; P00033; P06664; P00034; P00047; P00005; P00030; P00019; P00048; P04398"]
["PI3 Kinase p85/p55 - phospho","p85 Tyr458/ p55 Tyr199","PIK3R3","85, 60","rb",null,2,6,"n/a","n/a","n/a","n/a","# 2436",".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CD., .CML., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMU., .IMUF., .IMUR., .INS., .INT., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","T cell activation; p53 pathway; Axon guidance mediated by netrin; VEGF signaling pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; Hypoxia response via HIF activation; Endothelin signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA","B cell differentiation; cell migration involved in sprouting angiogenesis; immune response; insulin receptor signaling pathway; negative regulation of anoikis; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; positive regulation of cell migration; positive regulation of gene expression; positive regulation of protein phosphorylation; protein kinase B signaling; regulation of phosphatidylinositol 3-kinase activity; T cell differentiation","1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity; phosphotyrosine residue binding; protein binding","cytosol; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA",null,"phosphoinositide-3-kinase regulatory subunit 3","http://www.ncbi.nlm.nih.gov/gene/?term=8503","8503","18710",null,null,null,null,"Q92569","Q64143","A0A8I6A9P1","A0A8I3P519","A0A287BB64",null,"GO:0005829; GO:0005942; GO:0005943","GO:0016303; GO:0046935; GO:0001784; GO:0005515","GO:0030183; GO:0002042; GO:0006955; GO:0008286; GO:2000811; GO:0046854; GO:0036092; GO:0030335; GO:0010628; GO:0001934; GO:0043491; GO:0043551; GO:0030217","PTHR10155:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8981|UniProtKB=Q92569","P00053; P00059; P00009; P00056; P00033; P00034; P00047; P00005; P00030; P00019; P00048; P04398"]
["PIP4K2B",null,"PIP4K2B","48","rb",null,1,2,7,1.1000000000000001,1,1,"# 1556",".APH., .CD., .CSP., .INS., .OPA., .SREME., .ST.",null,"PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 BETA","1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; autophagosome-lysosome fusion; cell surface receptor signaling pathway; lipid metabolic process; negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity; negative regulation of insulin receptor signaling pathway; phosphatidylinositol metabolic process; phosphatidylinositol phosphate biosynthetic process; phosphorylation; positive regulation of autophagosome assembly; regulation of autophagy","1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding; GTP binding; kinase activity; nucleotide binding; phosphatidylinositol phosphate kinase activity; protein binding; protein homodimerization activity; transferase activity","autophagosome; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleoplasm; nucleus; plasma membrane","Ca / cAMP / lipid signaling","phosphatidylinositol-5-phosphate 4-kinase type 2 beta","http://www.ncbi.nlm.nih.gov/gene/?term=8396","8396","108083","89812","491034",null,null,"P78356","Q80XI4","O88377","A0A8I3RXU6",null,"A0A1D5QNB6","GO:0005776; GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0005654; GO:0005634; GO:0005886","GO:0016308; GO:0016309; GO:0005524; GO:0005525; GO:0016301; GO:0000166; GO:0016307; GO:0005515; GO:0042803; GO:0016740","GO:1902635; GO:0061909; GO:0007166; GO:0006629; GO:0090217; GO:0046627; GO:0046488; GO:0046854; GO:0016310; GO:2000786; GO:0010506","PTHR23086:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8998|UniProtKB=P78356"]
["PIP5K1A",null,"PIP5K1A","62","rb",null,2,2,6,6,2.1,8,"# 1555",".CSP., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST.",null,"PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 ALPHA","actin cytoskeleton reorganization; activation of GTPase activity; cell chemotaxis; cell migration; fibroblast migration; focal adhesion assembly; glycerophospholipid metabolic process; keratinocyte differentiation; lipid metabolic process; phagocytosis; phosphatidylinositol biosynthetic process; phosphatidylinositol metabolic process; phosphatidylinositol phosphate biosynthetic process; phospholipid biosynthetic process; phosphorylation; protein localization to plasma membrane; regulation of phosphatidylinositol 3-kinase signaling; ruffle assembly; signal transduction","1-phosphatidylinositol-3-phosphate 5-kinase activity; 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-kinase activity; ATP binding; kinase activity; kinase binding; nucleotide binding; phosphatidylinositol phosphate kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; protein binding; transferase activity","cell projection; cytoplasm; cytosol; focal adhesion; lamellipodium; membrane; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck; nucleoplasm; nucleus; plasma membrane; ruffle; ruffle membrane","Ca / cAMP / lipid signaling","phosphatidylinositol-4-phosphate 5-kinase type 1 alpha","http://www.ncbi.nlm.nih.gov/gene/?term=8394","8394","18720","365865","475846","100624272","710007","Q99755","P70182","A0A8I6A5T8","A0A8I3PB14","A0A287A4F0","A0A1D5QPX6","GO:0042995; GO:0005737; GO:0005829; GO:0005925; GO:0030027; GO:0016020; GO:0005847; GO:0016607; GO:0005654; GO:0005634; GO:0005886; GO:0001726; GO:0032587","GO:0000285; GO:0016308; GO:0052810; GO:0005524; GO:0016301; GO:0019900; GO:0000166; GO:0016307; GO:0052812; GO:0005515; GO:0016740","GO:0031532; GO:0090630; GO:0060326; GO:0016477; GO:0010761; GO:0048041; GO:0006650; GO:0030216; GO:0006629; GO:0006909; GO:0006661; GO:0046488; GO:0046854; GO:0008654; GO:0016310; GO:0072659; GO:0014066; GO:0097178; GO:0007165","PTHR23086:SF54","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8994|UniProtKB=Q99755"]
["PKA C alpha",null,"PRKACA","42","rb",null,1,1,1,6,1,2,"# 2431",".APH., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D200., .D300., .DEV., .DRAS., .ENDO., .GPCR., .GPROT., .HHSP., .IMUF., .INFM., .INS., .MAPK., .OP., .OPA., .OT., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .WNT.","Nicotine pharmacodynamics pathway; CCKR signaling map; Beta1 adrenergic receptor signaling pathway; 5HT1 type receptor mediated signaling pathway; Dopamine receptor mediated signaling pathway; Enkephalin release; Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction; Metabotropic glutamate receptor group II pathway; Metabotropic glutamate receptor group III pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Beta2 adrenergic receptor signaling pathway; Muscarinic acetylcholine receptor 2 and 4 signaling pathway; Histamine H2 receptor mediated signaling pathway; Metabotropic glutamate receptor group I pathway; GABA-B_receptor_II_signaling; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA","adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcium-mediated signaling using intracellular calcium source; cell communication by electrical coupling involved in cardiac conduction; cellular response to cold; cellular response to epinephrine stimulus; cellular response to glucose stimulus; cellular response to heat; cellular response to parathyroid hormone stimulus; cytokine-mediated signaling pathway; high-density lipoprotein particle assembly; mesoderm formation; modulation of chemical synaptic transmission; mRNA processing; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; neural tube closure; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of insulin secretion; positive regulation of protein export from nucleus; postsynaptic modulation of chemical synaptic transmission; protein autophosphorylation; protein export from nucleus; protein kinase A signaling; protein localization to lipid droplet; protein phosphorylation; regulation of bicellular tight junction assembly; regulation of cardiac conduction; regulation of cardiac muscle contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cell cycle; regulation of cytosolic calcium ion concentration; regulation of heart rate; regulation of macroautophagy; regulation of osteoblast differentiation; regulation of proteasomal protein catabolic process; regulation of protein binding; regulation of protein processing; regulation of ryanodine-sensitive calcium-release channel activity; renal water homeostasis; sperm capacitation","AMP-activated protein kinase activity; ATP binding; cAMP-dependent protein kinase activity; kinase activity; magnesium ion binding; manganese ion binding; nucleotide binding; protein binding; protein domain specific binding; protein kinase A regulatory subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding","acrosomal vesicle; axoneme; calcium channel complex; cAMP-dependent protein kinase complex; cell projection; centrosome; ciliary base; cilium; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; extracellular exosome; glutamatergic synapse; membrane; mitochondrion; motile cilium; neuromuscular junction; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane raft; sperm flagellum","cAMP signaling / metabolism","protein kinase cAMP-activated catalytic subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5566","5566","18747",null,null,null,null,"P17612","P05132","A0A8I5YBQ9","A0A8I3PRW9","A0A286ZUD6","A0A1D5R1I4","GO:0001669; GO:0005930; GO:0034704; GO:0005952; GO:0042995; GO:0005813; GO:0097546; GO:0005929; GO:0005737; GO:0031410; GO:0005829; GO:0043197; GO:0070062; GO:0098978; GO:0016020; GO:0005739; GO:0031514; GO:0031594; GO:0016607; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0044853; GO:0036126","GO:0004679; GO:0005524; GO:0004691; GO:0016301; GO:0000287; GO:0030145; GO:0000166; GO:0005515; GO:0019904; GO:0034237; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0004712; GO:0016740; GO:0031625","GO:0007189; GO:0035584; GO:0086064; GO:0070417; GO:0071872; GO:0071333; GO:0034605; GO:0071374; GO:0019221; GO:0034380; GO:0001707; GO:0050804; GO:0006397; GO:1901621; GO:0001843; GO:0018105; GO:0018107; GO:0016310; GO:0032024; GO:0046827; GO:0099170; GO:0046777; GO:0006611; GO:0010737; GO:1990044; GO:0006468; GO:2000810; GO:1903779; GO:0055117; GO:0010881; GO:0051726; GO:0051480; GO:0002027; GO:0016241; GO:0045667; GO:0061136; GO:0043393; GO:0070613; GO:0060314; GO:0003091; GO:0048240","PTHR24353:SF82","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9380|UniProtKB=P17612","P06587; P06959; P04377; P04373; P05912; P05913; P00028; P00040; P00039; P00026; P04378; P00043; P04386; P00041; P05731; P00031; P00019"]
["PKA C alpha/beta/gamma - phospho","Thr197","PRKACA, PRKACB, PRKACG","42","rb",null,2,4,1,2.1,1.1000000000000001,2.1,"TK # 026",".APH., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D200., .D300., .DEV., .DRAS., .ENDO., .GPCR., .GPROT., .HHSP., .IMUF., .INFM., .INS., .MAPK., .OP., .OPA., .OT., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .WNT.","Nicotine pharmacodynamics pathway; CCKR signaling map; Beta1 adrenergic receptor signaling pathway; 5HT1 type receptor mediated signaling pathway; Dopamine receptor mediated signaling pathway; Enkephalin release; Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction; Metabotropic glutamate receptor group II pathway; Metabotropic glutamate receptor group III pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Beta2 adrenergic receptor signaling pathway; Muscarinic acetylcholine receptor 2 and 4 signaling pathway; Histamine H2 receptor mediated signaling pathway; Metabotropic glutamate receptor group I pathway; GABA-B_receptor_II_signaling; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA; CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA; CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA","adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcium-mediated signaling using intracellular calcium source; cell communication by electrical coupling involved in cardiac conduction; cellular response to cold; cellular response to epinephrine stimulus; cellular response to glucose stimulus; cellular response to heat; cellular response to parathyroid hormone stimulus; cytokine-mediated signaling pathway; high-density lipoprotein particle assembly; mesoderm formation; modulation of chemical synaptic transmission; mRNA processing; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; neural tube closure; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of insulin secretion; positive regulation of protein export from nucleus; postsynaptic modulation of chemical synaptic transmission; protein autophosphorylation; protein export from nucleus; protein kinase A signaling; protein localization to lipid droplet; protein phosphorylation; regulation of bicellular tight junction assembly; regulation of cardiac conduction; regulation of cardiac muscle contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cell cycle; regulation of cytosolic calcium ion concentration; regulation of heart rate; regulation of macroautophagy; regulation of osteoblast differentiation; regulation of proteasomal protein catabolic process; regulation of protein binding; regulation of protein processing; regulation of ryanodine-sensitive calcium-release channel activity; renal water homeostasis; sperm capacitation; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; signal transduction; male gonad development; spermatogenesis","AMP-activated protein kinase activity; ATP binding; cAMP-dependent protein kinase activity; kinase activity; magnesium ion binding; manganese ion binding; nucleotide binding; protein binding; protein domain specific binding; protein kinase A regulatory subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding","acrosomal vesicle; axoneme; calcium channel complex; cAMP-dependent protein kinase complex; cell projection; centrosome; ciliary base; cilium; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; extracellular exosome; glutamatergic synapse; membrane; mitochondrion; motile cilium; neuromuscular junction; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane raft; sperm flagellum","cAMP signaling / metabolism","protein kinase cAMP-activated catalytic subunit alpha; protein kinase cAMP-activated catalytic subunit beta; protein kinase cAMP-activated catalytic subunit gamma","http://www.ncbi.nlm.nih.gov/gene/?term=5566, http://www.ncbi.nlm.nih.gov/gene/?term=5567, http://www.ncbi.nlm.nih.gov/gene/?term=5568","5566, 5567, 5568","18747, 18749","NA, 293508","NA, 479975","","NA, 700652","P17612, P22694, P22612","P05132, P68181","A0A8I5YBQ9, P68182","A0A8I3PRW9, A0A8I3MHE8","A0A286ZUD6","A0A1D5R1I4, A0A1D5Q2Z5, F6UGA5","GO:0001669; GO:0005930; GO:0034704; GO:0005952; GO:0042995; GO:0005813; GO:0097546; GO:0005929; GO:0005737; GO:0031410; GO:0005829; GO:0043197; GO:0070062; GO:0098978; GO:0016020; GO:0005739; GO:0031514; GO:0031594; GO:0016607; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0044853; GO:0036126","GO:0004679; GO:0005524; GO:0004691; GO:0016301; GO:0000287; GO:0030145; GO:0000166; GO:0005515; GO:0019904; GO:0034237; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0004712; GO:0016740; GO:0031625","GO:0007189; GO:0035584; GO:0086064; GO:0070417; GO:0071872; GO:0071333; GO:0034605; GO:0071374; GO:0019221; GO:0034380; GO:0001707; GO:0050804; GO:0006397; GO:1901621; GO:0001843; GO:0018105; GO:0018107; GO:0016310; GO:0032024; GO:0046827; GO:0099170; GO:0046777; GO:0006611; GO:0010737; GO:1990044; GO:0006468; GO:2000810; GO:1903779; GO:0055117; GO:0010881; GO:0051726; GO:0051480; GO:0002027; GO:0016241; GO:0045667; GO:0061136; GO:0043393; GO:0070613; GO:0060314; GO:0003091; GO:0048240; GO:0007188; GO:0007165; GO:0008584; GO:0007283","PTHR24353:SF82; PTHR24353:SF150; PTHR24353:SF137","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9380|UniProtKB=P17612; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9381|UniProtKB=P22694; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9382|UniProtKB=P22612","P06587; P06959; P04377; P04373; P05912; P05913; P00028; P00040; P00039; P00026; P04378; P00043; P04386; P00041; P05731; P00031; P00019"]
["PKA substrates - phospho","Ser/Thr","PRKACA","n.a.","rb",null,2,2,1,8,8,8,"# 2716",".APH., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CSP., .DEV., .ENDO., .GPCR., .GPROT., .HHSP., .IMUF., .INFM., .INS., .MAPK., .OP., .OPA., .OT., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .WNT.","Nicotine pharmacodynamics pathway; CCKR signaling map; Beta1 adrenergic receptor signaling pathway; 5HT1 type receptor mediated signaling pathway; Dopamine receptor mediated signaling pathway; Enkephalin release; Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction; Metabotropic glutamate receptor group II pathway; Metabotropic glutamate receptor group III pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Beta2 adrenergic receptor signaling pathway; Muscarinic acetylcholine receptor 2 and 4 signaling pathway; Histamine H2 receptor mediated signaling pathway; Metabotropic glutamate receptor group I pathway; GABA-B_receptor_II_signaling; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA","adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcium-mediated signaling using intracellular calcium source; cell communication by electrical coupling involved in cardiac conduction; cellular response to cold; cellular response to epinephrine stimulus; cellular response to glucose stimulus; cellular response to heat; cellular response to parathyroid hormone stimulus; cytokine-mediated signaling pathway; high-density lipoprotein particle assembly; mesoderm formation; modulation of chemical synaptic transmission; mRNA processing; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; neural tube closure; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of insulin secretion; positive regulation of protein export from nucleus; postsynaptic modulation of chemical synaptic transmission; protein autophosphorylation; protein export from nucleus; protein kinase A signaling; protein localization to lipid droplet; protein phosphorylation; regulation of bicellular tight junction assembly; regulation of cardiac conduction; regulation of cardiac muscle contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cell cycle; regulation of cytosolic calcium ion concentration; regulation of heart rate; regulation of macroautophagy; regulation of osteoblast differentiation; regulation of proteasomal protein catabolic process; regulation of protein binding; regulation of protein processing; regulation of ryanodine-sensitive calcium-release channel activity; renal water homeostasis; sperm capacitation","AMP-activated protein kinase activity; ATP binding; cAMP-dependent protein kinase activity; kinase activity; magnesium ion binding; manganese ion binding; nucleotide binding; protein binding; protein domain specific binding; protein kinase A regulatory subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding","acrosomal vesicle; axoneme; calcium channel complex; cAMP-dependent protein kinase complex; cell projection; centrosome; ciliary base; cilium; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; extracellular exosome; glutamatergic synapse; membrane; mitochondrion; motile cilium; neuromuscular junction; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane raft; sperm flagellum","cAMP signaling / metabolism","protein kinase cAMP-activated catalytic subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5566","5566","18747",null,null,null,null,"P17612","P05132","A0A8I5YBQ9","A0A8I3PRW9","A0A286ZUD6","A0A1D5R1I4","GO:0001669; GO:0005930; GO:0034704; GO:0005952; GO:0042995; GO:0005813; GO:0097546; GO:0005929; GO:0005737; GO:0031410; GO:0005829; GO:0043197; GO:0070062; GO:0098978; GO:0016020; GO:0005739; GO:0031514; GO:0031594; GO:0016607; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0044853; GO:0036126","GO:0004679; GO:0005524; GO:0004691; GO:0016301; GO:0000287; GO:0030145; GO:0000166; GO:0005515; GO:0019904; GO:0034237; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0004712; GO:0016740; GO:0031625","GO:0007189; GO:0035584; GO:0086064; GO:0070417; GO:0071872; GO:0071333; GO:0034605; GO:0071374; GO:0019221; GO:0034380; GO:0001707; GO:0050804; GO:0006397; GO:1901621; GO:0001843; GO:0018105; GO:0018107; GO:0016310; GO:0032024; GO:0046827; GO:0099170; GO:0046777; GO:0006611; GO:0010737; GO:1990044; GO:0006468; GO:2000810; GO:1903779; GO:0055117; GO:0010881; GO:0051726; GO:0051480; GO:0002027; GO:0016241; GO:0045667; GO:0061136; GO:0043393; GO:0070613; GO:0060314; GO:0003091; GO:0048240","PTHR24353:SF82","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9380|UniProtKB=P17612","P06587; P06959; P04377; P04373; P05912; P05913; P00028; P00040; P00039; P00026; P04378; P00043; P04386; P00041; P05731; P00031; P00019"]
["PKC (pan) - phospho","Ser660","PRKCA, PRKCB, PRKCD, PRKCE, PRKCH, PRKCQ","85, 82, 80, 78","rb",null,1,2,1,1.1000000000000001,1,1,"# 2685",".ALZ., .ANG., .APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .MAPK., .MIG., .MTOR., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .TOLL., .TRASR., .UBI., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway; B cell activation; Metabotropic glutamate receptor group I pathway; Inflammation mediated by chemokine and cytokine signaling pathway; T cell activation","PROTEIN KINASE C ALPHA TYPE; PROTEIN KINASE C BETA TYPE; PROTEIN KINASE C DELTA TYPE; PROTEIN KINASE C EPSILON TYPE; PROTEIN KINASE C ETA TYPE; PROTEIN KINASE C THETA TYPE","angiogenesis; apoptotic process; apoptotic signaling pathway; cell adhesion; desmosome assembly; histone modification; intracellular signal transduction; mitotic nuclear membrane disassembly; negative regulation of glial cell apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of bone resorption; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; post-translational protein modification; protein phosphorylation; regulation of mRNA stability; regulation of platelet aggregation; response to interleukin-1; adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium ion transport; cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; chromatin organization; immune system process; lipoprotein transport; negative regulation of glucose transmembrane transport; negative regulation of insulin receptor signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; positive regulation of B cell receptor signaling pathway; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of NF-kappaB transcription factor activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; regulation of glucose transmembrane transport; regulation of synaptic vesicle exocytosis; regulation of transcription by RNA polymerase II; signal transduction; activation of protein kinase activity; B cell proliferation; cell chemotaxis; cell cycle; cellular response to angiotensin; cellular response to hydrogen peroxide; cellular response to hydroperoxide; cellular response to UV; cellular senescence; defense response to bacterium; Fc-gamma receptor signaling pathway involved in phagocytosis; immunoglobulin mediated immune response; intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of actin filament polymerization; negative regulation of filopodium assembly; negative regulation of inflammatory response; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of platelet aggregation; negative regulation of protein binding; neutrophil activation; peptidyl-tyrosine phosphorylation; positive regulation of apoptotic signaling pathway; positive regulation of ceramide biosynthetic process; positive regulation of endodeoxyribonuclease activity; positive regulation of glucosylceramide catabolic process; positive regulation of phospholipid scramblase activity; positive regulation of protein dephosphorylation; positive regulation of protein import into nucleus; positive regulation of response to DNA damage stimulus; positive regulation of sphingomyelin catabolic process; positive regulation of superoxide anion generation; protein stabilization; regulation of actin cytoskeleton organization; regulation of ceramide biosynthetic process; regulation of signaling receptor activity; termination of signal transduction; cell division; cell-substrate adhesion; cellular response to ethanol; cellular response to hypoxia; cellular response to prostaglandin E stimulus; establishment of localization in cell; insulin secretion; lipopolysaccharide-mediated signaling pathway; locomotory exploration behavior; macrophage activation involved in immune response; MAPK cascade; mucus secretion; negative regulation of protein ubiquitination; negative regulation of sodium ion transmembrane transporter activity; positive regulation of actin filament polymerization; positive regulation of cell-substrate adhesion; positive regulation of cellular glucuronidation; positive regulation of cytokinesis; positive regulation of epithelial cell migration; positive regulation of fibroblast migration; positive regulation of lipid catabolic process; positive regulation of MAPK cascade; positive regulation of mucus secretion; positive regulation of protein localization to plasma membrane; positive regulation of synaptic transmission, GABAergic; positive regulation of wound healing; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of lipid metabolic process; regulation of peptidyl-tyrosine phosphorylation; regulation of release of sequestered calcium ion into cytosol; response to morphine; synaptic transmission, GABAergic; TRAM-dependent toll-like receptor 4 signaling pathway; cell differentiation; positive regulation of glial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of macrophage derived foam cell differentiation; protein kinase C signaling; regulation of bicellular tight junction assembly; axon guidance; CD4-positive, alpha-beta T cell proliferation; Fc-epsilon receptor signaling pathway; inflammatory response; membrane protein ectodomain proteolysis; negative regulation of T cell apoptotic process; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of interleukin-17 production; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of T cell activation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of T-helper 17 type immune response; positive regulation of T-helper 2 cell activation; regulation of cell growth; regulation of DNA-templated transcription; T cell activation","ATP binding; calcium-dependent protein kinase C activity; enzyme binding; histone H3T6 kinase activity; integrin binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding; calcium channel regulator activity; chromatin binding; histone binding; nuclear androgen receptor binding; nuclear receptor coactivator activity; protein kinase C binding; calcium-independent protein kinase C activity; enzyme activator activity; insulin receptor substrate binding; non-membrane spanning protein tyrosine kinase activity; protein kinase binding; protein tyrosine kinase activity; 14-3-3 protein binding; actin monomer binding; ethanol binding; signaling receptor activator activity; small GTPase binding","alphav-beta3 integrin-PKCalpha complex; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane; mitochondrial membrane; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; calyx of Held; presynaptic cytosol; spectrin; azurophil granule lumen; cell-cell junction; endolysosome; endomembrane system; extracellular region; nuclear matrix; cell periphery; cytoskeleton; Golgi apparatus; intermediate filament cytoskeleton; intracellular membrane-bounded organelle; synapse; aggresome; centriolar satellite; immunological synapse","cAMP signaling / metabolism","protein kinase C alpha; protein kinase C beta; protein kinase C delta; protein kinase C epsilon; protein kinase C eta; protein kinase C theta","http://www.ncbi.nlm.nih.gov/gene/?term=5578, http://www.ncbi.nlm.nih.gov/gene/?term=5579, http://www.ncbi.nlm.nih.gov/gene/?term=5580, http://www.ncbi.nlm.nih.gov/gene/?term=5581, http://www.ncbi.nlm.nih.gov/gene/?term=5583, http://www.ncbi.nlm.nih.gov/gene/?term=5588","5578, 5579, 5580, 5581, 5583, 5588","NA, 18751, 18753, 18754, 18755, 18761","NA, 25023, 81749","NA, 490722",null,null,"P17252, P05771, P05771-2, Q05655, Q02156, P24723, Q04759","Q3TQ39, P68404, P28867, P16054, P23298, Q02111","P05696, P68403, A0A140UHX0, A0A0G2JXV8, Q64617, A0A8I6A0B5","A0A8I3PUQ8, A0A8I3MFL8, A0A8I3PZJ7, A0A8I3PUK1, A0A8P0NH77, A0A8I3MIR2","A0A8W4F9E9, A0A287A287, A0A287AHR4, A0A5G2QQU6, A0A287A0E4","A0A1D5R985, A0A5F8AEL4, A0A5F8ADY8, A0A1D5QIW0, A0A5F8AHU8, F7HC75","GO:0035866; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0016020; GO:0031966; GO:0005739; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0044305; GO:0099523; GO:0008091; GO:0035578; GO:0005911; GO:0036019; GO:0012505; GO:0005576; GO:0016363; GO:0071944; GO:0005856; GO:0005794; GO:0045111; GO:0043231; GO:0045202; GO:0016235; GO:0034451; GO:0001772","GO:0005524; GO:0004698; GO:0019899; GO:0035403; GO:0005178; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740; GO:0008270; GO:0005246; GO:0003682; GO:0042393; GO:0050681; GO:0030374; GO:0005080; GO:0004699; GO:0008047; GO:0043560; GO:0004715; GO:0019901; GO:0004713; GO:0071889; GO:0003785; GO:0035276; GO:0030546; GO:0031267","GO:0001525; GO:0006915; GO:0097190; GO:0007155; GO:0002159; GO:0016570; GO:0035556; GO:0007077; GO:0034351; GO:0018105; GO:0018107; GO:0016310; GO:0106071; GO:0045766; GO:0043536; GO:0045780; GO:0010613; GO:0045785; GO:0030335; GO:2000707; GO:0010595; GO:0001938; GO:0070374; GO:0031666; GO:0045651; GO:0045931; GO:0043687; GO:0006468; GO:0043488; GO:0090330; GO:0070555; GO:0002250; GO:0042113; GO:0050853; GO:0006816; GO:0006874; GO:0071322; GO:0006325; GO:0002376; GO:0042953; GO:0010829; GO:0046627; GO:0007207; GO:0050861; GO:0045893; GO:0043123; GO:0032024; GO:0051092; GO:0030949; GO:0099171; GO:0010827; GO:2000300; GO:0006357; GO:0007165; GO:0032147; GO:0042100; GO:0060326; GO:0007049; GO:1904385; GO:0070301; GO:0071447; GO:0034644; GO:0090398; GO:0042742; GO:0038096; GO:0016064; GO:0008631; GO:0030837; GO:0051490; GO:0050728; GO:0043407; GO:0050732; GO:0090331; GO:0032091; GO:0042119; GO:0018108; GO:2001235; GO:2000304; GO:0032079; GO:2000753; GO:1900163; GO:0035307; GO:0042307; GO:2001022; GO:2000755; GO:0032930; GO:0050821; GO:0032956; GO:2000303; GO:0010469; GO:0023021; GO:0051301; GO:0031589; GO:0071361; GO:0071456; GO:0071380; GO:0051649; GO:0030073; GO:0031663; GO:0035641; GO:0002281; GO:0000165; GO:0070254; GO:0031397; GO:2000650; GO:0030838; GO:0010811; GO:2001031; GO:0032467; GO:0010634; GO:0010763; GO:0050996; GO:0043410; GO:0070257; GO:1903078; GO:0032230; GO:0090303; GO:0061178; GO:0019216; GO:0050730; GO:0051279; GO:0043278; GO:0051932; GO:0035669; GO:0030154; GO:0060252; GO:0045618; GO:0010744; GO:0070528; GO:2000810; GO:0007411; GO:0035739; GO:0038095; GO:0006954; GO:0006509; GO:0070233; GO:2000563; GO:0032740; GO:0032743; GO:0032753; GO:0050870; GO:0051973; GO:1904355; GO:0032212; GO:2000318; GO:2000570; GO:0001558; GO:0006355; GO:0042110","PTHR24356:SF193; PTHR24356:SF158; PTHR24356:SF365; PTHR24356:SF159; PTHR24356:SF192; PTHR24356:SF181","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9393|UniProtKB=P17252; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9395|UniProtKB=P05771; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9399|UniProtKB=Q05655; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9401|UniProtKB=Q02156; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9403|UniProtKB=P24723; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9410|UniProtKB=Q04759","P00027; P06959; P04385; P04374; P00042; P00056; P04391; P00002; P06664; P00021; P04394; P00047; P05911; P00005; P00018; P00003; P00019; P00057; P00006; P00010; P00041; P00031; P00053"]
["PKC (pan) gamma - phospho","Thr514","PRKCA, PRKCB, PRKCD, PRKCE, PRKCH, PRKCG, PRKCQ","85, 82, 80, 78","rb",null,1,2,"n/a","n/a","n/a","n/a","# 2378",".ALZ., .ANG., .APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DREP., .DRR., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .MAPK., .MIG., .MTOR., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .TOLL., .TRASR., .UBI., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway; B cell activation; Metabotropic glutamate receptor group I pathway; Inflammation mediated by chemokine and cytokine signaling pathway; T cell activation","PROTEIN KINASE C ALPHA TYPE; PROTEIN KINASE C BETA TYPE; PROTEIN KINASE C DELTA TYPE; PROTEIN KINASE C EPSILON TYPE; PROTEIN KINASE C ETA TYPE; PROTEIN KINASE C GAMMA TYPE; PROTEIN KINASE C THETA TYPE","angiogenesis; apoptotic process; apoptotic signaling pathway; cell adhesion; desmosome assembly; histone modification; intracellular signal transduction; mitotic nuclear membrane disassembly; negative regulation of glial cell apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of bone resorption; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; post-translational protein modification; protein phosphorylation; regulation of mRNA stability; regulation of platelet aggregation; response to interleukin-1; adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium ion transport; cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; chromatin organization; immune system process; lipoprotein transport; negative regulation of glucose transmembrane transport; negative regulation of insulin receptor signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; positive regulation of B cell receptor signaling pathway; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of NF-kappaB transcription factor activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; regulation of glucose transmembrane transport; regulation of synaptic vesicle exocytosis; regulation of transcription by RNA polymerase II; signal transduction; activation of protein kinase activity; B cell proliferation; cell chemotaxis; cell cycle; cellular response to angiotensin; cellular response to hydrogen peroxide; cellular response to hydroperoxide; cellular response to UV; cellular senescence; defense response to bacterium; Fc-gamma receptor signaling pathway involved in phagocytosis; immunoglobulin mediated immune response; intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of actin filament polymerization; negative regulation of filopodium assembly; negative regulation of inflammatory response; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of platelet aggregation; negative regulation of protein binding; neutrophil activation; peptidyl-tyrosine phosphorylation; positive regulation of apoptotic signaling pathway; positive regulation of ceramide biosynthetic process; positive regulation of endodeoxyribonuclease activity; positive regulation of glucosylceramide catabolic process; positive regulation of phospholipid scramblase activity; positive regulation of protein dephosphorylation; positive regulation of protein import into nucleus; positive regulation of response to DNA damage stimulus; positive regulation of sphingomyelin catabolic process; positive regulation of superoxide anion generation; protein stabilization; regulation of actin cytoskeleton organization; regulation of ceramide biosynthetic process; regulation of signaling receptor activity; termination of signal transduction; cell division; cell-substrate adhesion; cellular response to ethanol; cellular response to hypoxia; cellular response to prostaglandin E stimulus; establishment of localization in cell; insulin secretion; lipopolysaccharide-mediated signaling pathway; locomotory exploration behavior; macrophage activation involved in immune response; MAPK cascade; mucus secretion; negative regulation of protein ubiquitination; negative regulation of sodium ion transmembrane transporter activity; positive regulation of actin filament polymerization; positive regulation of cell-substrate adhesion; positive regulation of cellular glucuronidation; positive regulation of cytokinesis; positive regulation of epithelial cell migration; positive regulation of fibroblast migration; positive regulation of lipid catabolic process; positive regulation of MAPK cascade; positive regulation of mucus secretion; positive regulation of protein localization to plasma membrane; positive regulation of synaptic transmission, GABAergic; positive regulation of wound healing; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of lipid metabolic process; regulation of peptidyl-tyrosine phosphorylation; regulation of release of sequestered calcium ion into cytosol; response to morphine; synaptic transmission, GABAergic; TRAM-dependent toll-like receptor 4 signaling pathway; cell differentiation; positive regulation of glial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of macrophage derived foam cell differentiation; protein kinase C signaling; regulation of bicellular tight junction assembly; chemical synaptic transmission; chemosensory behavior; innervation; learning or memory; long-term synaptic potentiation; negative regulation of neuron apoptotic process; negative regulation of proteasomal protein catabolic process; negative regulation of protein catabolic process; positive regulation of mismatch repair; protein autophosphorylation; regulation of circadian rhythm; regulation of phagocytosis; regulation of response to food; response to pain; response to psychosocial stress; response to toxic substance; rhythmic process; axon guidance; CD4-positive, alpha-beta T cell proliferation; Fc-epsilon receptor signaling pathway; inflammatory response; membrane protein ectodomain proteolysis; negative regulation of T cell apoptotic process; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of interleukin-17 production; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of T cell activation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of T-helper 17 type immune response; positive regulation of T-helper 2 cell activation; regulation of cell growth; regulation of DNA-templated transcription; T cell activation","ATP binding; calcium-dependent protein kinase C activity; enzyme binding; histone H3T6 kinase activity; integrin binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding; calcium channel regulator activity; chromatin binding; histone binding; nuclear androgen receptor binding; nuclear receptor coactivator activity; protein kinase C binding; calcium-independent protein kinase C activity; enzyme activator activity; insulin receptor substrate binding; non-membrane spanning protein tyrosine kinase activity; protein kinase binding; protein tyrosine kinase activity; 14-3-3 protein binding; actin monomer binding; ethanol binding; signaling receptor activator activity; small GTPase binding; protein serine/threonine/tyrosine kinase activity","alphav-beta3 integrin-PKCalpha complex; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane; mitochondrial membrane; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; calyx of Held; presynaptic cytosol; spectrin; azurophil granule lumen; cell-cell junction; endolysosome; endomembrane system; extracellular region; nuclear matrix; cell periphery; cytoskeleton; Golgi apparatus; intermediate filament cytoskeleton; intracellular membrane-bounded organelle; synapse; cell projection; dendrite; neuron projection; postsynaptic cytosol; postsynaptic density; synaptic membrane; aggresome; centriolar satellite; immunological synapse",null,"protein kinase C alpha; protein kinase C beta; protein kinase C delta; protein kinase C epsilon; protein kinase C eta; protein kinase C gamma; protein kinase C theta","http://www.ncbi.nlm.nih.gov/gene/?term=5578, http://www.ncbi.nlm.nih.gov/gene/?term=5579, http://www.ncbi.nlm.nih.gov/gene/?term=5580, http://www.ncbi.nlm.nih.gov/gene/?term=5581, http://www.ncbi.nlm.nih.gov/gene/?term=5583, http://www.ncbi.nlm.nih.gov/gene/?term=5582, http://www.ncbi.nlm.nih.gov/gene/?term=5588","5578, 5579, 5580, 5581, 5583, 5582, 5588","NA, 18751, 18753, 18754, 18755, 18752, 18761","NA, 25023, 81749, 24681","NA, 490722",null,null,"P17252, P05771, P05771-2, Q05655, Q02156, P24723, P05129, Q04759","Q3TQ39, P68404, P28867, P16054, P23298, P63318, Q02111","P05696, P68403, A0A140UHX0, A0A0G2JXV8, Q64617, P63319, A0A8I6A0B5","A0A8I3PUQ8, A0A8I3MFL8, A0A8I3PZJ7, A0A8I3PUK1, A0A8P0NH77, A0A8I3MM53, A0A8I3MIR2","A0A8W4F9E9, A0A287A287, A0A287AHR4, A0A5G2QQU6, A0A5G2QM77, A0A287A0E4","A0A1D5R985, A0A5F8AEL4, A0A5F8ADY8, A0A1D5QIW0, A0A5F8AHU8, A0A5F8AQE3, F7HC75","GO:0035866; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0016020; GO:0031966; GO:0005739; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0044305; GO:0099523; GO:0008091; GO:0035578; GO:0005911; GO:0036019; GO:0012505; GO:0005576; GO:0016363; GO:0071944; GO:0005856; GO:0005794; GO:0045111; GO:0043231; GO:0045202; GO:0042995; GO:0030425; GO:0043005; GO:0099524; GO:0014069; GO:0097060; GO:0016235; GO:0034451; GO:0001772","GO:0005524; GO:0004698; GO:0019899; GO:0035403; GO:0005178; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740; GO:0008270; GO:0005246; GO:0003682; GO:0042393; GO:0050681; GO:0030374; GO:0005080; GO:0004699; GO:0008047; GO:0043560; GO:0004715; GO:0019901; GO:0004713; GO:0071889; GO:0003785; GO:0035276; GO:0030546; GO:0031267; GO:0004712","GO:0001525; GO:0006915; GO:0097190; GO:0007155; GO:0002159; GO:0016570; GO:0035556; GO:0007077; GO:0034351; GO:0018105; GO:0018107; GO:0016310; GO:0106071; GO:0045766; GO:0043536; GO:0045780; GO:0010613; GO:0045785; GO:0030335; GO:2000707; GO:0010595; GO:0001938; GO:0070374; GO:0031666; GO:0045651; GO:0045931; GO:0043687; GO:0006468; GO:0043488; GO:0090330; GO:0070555; GO:0002250; GO:0042113; GO:0050853; GO:0006816; GO:0006874; GO:0071322; GO:0006325; GO:0002376; GO:0042953; GO:0010829; GO:0046627; GO:0007207; GO:0050861; GO:0045893; GO:0043123; GO:0032024; GO:0051092; GO:0030949; GO:0099171; GO:0010827; GO:2000300; GO:0006357; GO:0007165; GO:0032147; GO:0042100; GO:0060326; GO:0007049; GO:1904385; GO:0070301; GO:0071447; GO:0034644; GO:0090398; GO:0042742; GO:0038096; GO:0016064; GO:0008631; GO:0030837; GO:0051490; GO:0050728; GO:0043407; GO:0050732; GO:0090331; GO:0032091; GO:0042119; GO:0018108; GO:2001235; GO:2000304; GO:0032079; GO:2000753; GO:1900163; GO:0035307; GO:0042307; GO:2001022; GO:2000755; GO:0032930; GO:0050821; GO:0032956; GO:2000303; GO:0010469; GO:0023021; GO:0051301; GO:0031589; GO:0071361; GO:0071456; GO:0071380; GO:0051649; GO:0030073; GO:0031663; GO:0035641; GO:0002281; GO:0000165; GO:0070254; GO:0031397; GO:2000650; GO:0030838; GO:0010811; GO:2001031; GO:0032467; GO:0010634; GO:0010763; GO:0050996; GO:0043410; GO:0070257; GO:1903078; GO:0032230; GO:0090303; GO:0061178; GO:0019216; GO:0050730; GO:0051279; GO:0043278; GO:0051932; GO:0035669; GO:0030154; GO:0060252; GO:0045618; GO:0010744; GO:0070528; GO:2000810; GO:0007268; GO:0007635; GO:0060384; GO:0007611; GO:0060291; GO:0043524; GO:1901799; GO:0042177; GO:0032425; GO:0046777; GO:0042752; GO:0050764; GO:0032095; GO:0048265; GO:1990911; GO:0009636; GO:0048511; GO:0007411; GO:0035739; GO:0038095; GO:0006954; GO:0006509; GO:0070233; GO:2000563; GO:0032740; GO:0032743; GO:0032753; GO:0050870; GO:0051973; GO:1904355; GO:0032212; GO:2000318; GO:2000570; GO:0001558; GO:0006355; GO:0042110","PTHR24356:SF193; PTHR24356:SF158; PTHR24356:SF365; PTHR24356:SF159; PTHR24356:SF192; PTHR24356:SF162; PTHR24356:SF181","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9393|UniProtKB=P17252; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9395|UniProtKB=P05771; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9399|UniProtKB=Q05655; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9401|UniProtKB=Q02156; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9403|UniProtKB=P24723; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9402|UniProtKB=P05129; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9410|UniProtKB=Q04759","P00027; P06959; P04385; P04374; P00042; P00056; P04391; P00002; P06664; P00021; P04394; P00047; P05911; P00005; P00018; P00003; P00019; P00057; P00006; P00010; P00041; P00031; P00053"]
["PKC alpha",null,"PRKCA","82","ms",null,1.1000000000000001,1,6,1.1000000000000001,1.1000000000000001,1.1000000000000001,"# 2440",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .MAPK., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C ALPHA TYPE","angiogenesis; apoptotic process; apoptotic signaling pathway; cell adhesion; desmosome assembly; histone modification; intracellular signal transduction; mitotic nuclear membrane disassembly; negative regulation of glial cell apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of bone resorption; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; post-translational protein modification; protein phosphorylation; regulation of mRNA stability; regulation of platelet aggregation; response to interleukin-1","ATP binding; calcium-dependent protein kinase C activity; enzyme binding; histone H3T6 kinase activity; integrin binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding","alphav-beta3 integrin-PKCalpha complex; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane; mitochondrial membrane; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane","cAMP signaling / metabolism","protein kinase C alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5578","5578",null,null,null,null,null,"P17252","Q3TQ39","P05696","A0A8I3PUQ8","A0A8W4F9E9","A0A1D5R985","GO:0035866; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0016020; GO:0031966; GO:0005739; GO:0005654; GO:0005634; GO:0048471; GO:0005886","GO:0005524; GO:0004698; GO:0019899; GO:0035403; GO:0005178; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740; GO:0008270","GO:0001525; GO:0006915; GO:0097190; GO:0007155; GO:0002159; GO:0016570; GO:0035556; GO:0007077; GO:0034351; GO:0018105; GO:0018107; GO:0016310; GO:0106071; GO:0045766; GO:0043536; GO:0045780; GO:0010613; GO:0045785; GO:0030335; GO:2000707; GO:0010595; GO:0001938; GO:0070374; GO:0031666; GO:0045651; GO:0045931; GO:0043687; GO:0006468; GO:0043488; GO:0090330; GO:0070555","PTHR24356:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9393|UniProtKB=P17252","P00027; P06959; P04385; P04374; P00042; P00056; P04391; P00002; P06664; P00021; P04394; P00047; P05911; P00005; P00018; P00003; P00019; P00057; P00006"]
["PKC alpha - phospho","Ser657","PRKCA","77","rb",null,2,1,"n/a","n/a","n/a","n/a","# 3027",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .MAPK., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C ALPHA TYPE","angiogenesis; apoptotic process; apoptotic signaling pathway; cell adhesion; desmosome assembly; histone modification; intracellular signal transduction; mitotic nuclear membrane disassembly; negative regulation of glial cell apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of bone resorption; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; post-translational protein modification; protein phosphorylation; regulation of mRNA stability; regulation of platelet aggregation; response to interleukin-1","ATP binding; calcium-dependent protein kinase C activity; enzyme binding; histone H3T6 kinase activity; integrin binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding","alphav-beta3 integrin-PKCalpha complex; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane; mitochondrial membrane; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane",null,"protein kinase C alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5578","5578",null,null,null,null,null,"P17252","Q3TQ39","P05696","A0A8I3PUQ8","A0A8W4F9E9","A0A1D5R985","GO:0035866; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0016020; GO:0031966; GO:0005739; GO:0005654; GO:0005634; GO:0048471; GO:0005886","GO:0005524; GO:0004698; GO:0019899; GO:0035403; GO:0005178; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740; GO:0008270","GO:0001525; GO:0006915; GO:0097190; GO:0007155; GO:0002159; GO:0016570; GO:0035556; GO:0007077; GO:0034351; GO:0018105; GO:0018107; GO:0016310; GO:0106071; GO:0045766; GO:0043536; GO:0045780; GO:0010613; GO:0045785; GO:0030335; GO:2000707; GO:0010595; GO:0001938; GO:0070374; GO:0031666; GO:0045651; GO:0045931; GO:0043687; GO:0006468; GO:0043488; GO:0090330; GO:0070555","PTHR24356:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9393|UniProtKB=P17252","P00027; P06959; P04385; P04374; P00042; P00056; P04391; P00002; P06664; P00021; P04394; P00047; P05911; P00005; P00018; P00003; P00019; P00057; P00006"]
["PKC alpha - phospho","Thr497","PRKCA","77","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2856",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .MAPK., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C ALPHA TYPE","angiogenesis; apoptotic process; apoptotic signaling pathway; cell adhesion; desmosome assembly; histone modification; intracellular signal transduction; mitotic nuclear membrane disassembly; negative regulation of glial cell apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of bone resorption; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; post-translational protein modification; protein phosphorylation; regulation of mRNA stability; regulation of platelet aggregation; response to interleukin-1","ATP binding; calcium-dependent protein kinase C activity; enzyme binding; histone H3T6 kinase activity; integrin binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding","alphav-beta3 integrin-PKCalpha complex; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane; mitochondrial membrane; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane",null,"protein kinase C alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5578","5578",null,null,null,null,null,"P17252","Q3TQ39","P05696","A0A8I3PUQ8","A0A8W4F9E9","A0A1D5R985","GO:0035866; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0016020; GO:0031966; GO:0005739; GO:0005654; GO:0005634; GO:0048471; GO:0005886","GO:0005524; GO:0004698; GO:0019899; GO:0035403; GO:0005178; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740; GO:0008270","GO:0001525; GO:0006915; GO:0097190; GO:0007155; GO:0002159; GO:0016570; GO:0035556; GO:0007077; GO:0034351; GO:0018105; GO:0018107; GO:0016310; GO:0106071; GO:0045766; GO:0043536; GO:0045780; GO:0010613; GO:0045785; GO:0030335; GO:2000707; GO:0010595; GO:0001938; GO:0070374; GO:0031666; GO:0045651; GO:0045931; GO:0043687; GO:0006468; GO:0043488; GO:0090330; GO:0070555","PTHR24356:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9393|UniProtKB=P17252","P00027; P06959; P04385; P04374; P00042; P00056; P04391; P00002; P06664; P00021; P04394; P00047; P05911; P00005; P00018; P00003; P00019; P00057; P00006"]
["PKC alpha/beta II - phospho","Thr638/Thr641","PRKCA, PRKCB","82, 80","rb",null,1,1,1,1,1,2,"# 2485",".ALZ., .ANG., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMU., .IMUF., .IMUR., .INFM., .INS., .MAPK., .MIG., .MTOR., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway; B cell activation; Metabotropic glutamate receptor group I pathway; Inflammation mediated by chemokine and cytokine signaling pathway","PROTEIN KINASE C ALPHA TYPE; PROTEIN KINASE C BETA TYPE","angiogenesis; apoptotic process; apoptotic signaling pathway; cell adhesion; desmosome assembly; histone modification; intracellular signal transduction; mitotic nuclear membrane disassembly; negative regulation of glial cell apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of bone resorption; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; post-translational protein modification; protein phosphorylation; regulation of mRNA stability; regulation of platelet aggregation; response to interleukin-1; adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium ion transport; cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; chromatin organization; immune system process; lipoprotein transport; negative regulation of glucose transmembrane transport; negative regulation of insulin receptor signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; positive regulation of B cell receptor signaling pathway; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of NF-kappaB transcription factor activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; regulation of glucose transmembrane transport; regulation of synaptic vesicle exocytosis; regulation of transcription by RNA polymerase II; signal transduction","ATP binding; calcium-dependent protein kinase C activity; enzyme binding; histone H3T6 kinase activity; integrin binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding; calcium channel regulator activity; chromatin binding; histone binding; nuclear androgen receptor binding; nuclear receptor coactivator activity; protein kinase C binding","alphav-beta3 integrin-PKCalpha complex; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane; mitochondrial membrane; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; calyx of Held; presynaptic cytosol; spectrin","cAMP signaling / metabolism","protein kinase C alpha; protein kinase C beta","http://www.ncbi.nlm.nih.gov/gene/?term=5578, http://www.ncbi.nlm.nih.gov/gene/?term=5579","5578, 5579","NA, 18751","NA, 25023",null,"",null,"P17252, P05771","Q3TQ39, P68404","P05696, P68403","A0A8I3PUQ8, A0A8I3MFL8","A0A8W4F9E9","A0A1D5R985, A0A5F8AEL4","GO:0035866; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0016020; GO:0031966; GO:0005739; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0044305; GO:0099523; GO:0008091","GO:0005524; GO:0004698; GO:0019899; GO:0035403; GO:0005178; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740; GO:0008270; GO:0005246; GO:0003682; GO:0042393; GO:0050681; GO:0030374; GO:0005080","GO:0001525; GO:0006915; GO:0097190; GO:0007155; GO:0002159; GO:0016570; GO:0035556; GO:0007077; GO:0034351; GO:0018105; GO:0018107; GO:0016310; GO:0106071; GO:0045766; GO:0043536; GO:0045780; GO:0010613; GO:0045785; GO:0030335; GO:2000707; GO:0010595; GO:0001938; GO:0070374; GO:0031666; GO:0045651; GO:0045931; GO:0043687; GO:0006468; GO:0043488; GO:0090330; GO:0070555; GO:0002250; GO:0042113; GO:0050853; GO:0006816; GO:0006874; GO:0071322; GO:0006325; GO:0002376; GO:0042953; GO:0010829; GO:0046627; GO:0007207; GO:0050861; GO:0045893; GO:0043123; GO:0032024; GO:0051092; GO:0030949; GO:0099171; GO:0010827; GO:2000300; GO:0006357; GO:0007165","PTHR24356:SF193; PTHR24356:SF158","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9393|UniProtKB=P17252; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9395|UniProtKB=P05771","P00027; P06959; P04385; P04374; P00042; P00056; P04391; P00002; P06664; P00021; P04394; P00047; P05911; P00005; P00018; P00003; P00019; P00057; P00006; P00010; P00041; P00031"]
["PKC alpha/beta/gamma",null,"PRKCA, PRKCB, PRKCG","82","rb",null,6,6,"n/a","n/a","n/a","n/a","TK # 080",".ALZ., .ANG., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .DREP., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMU., .IMUF., .IMUR., .INFM., .INS., .MAPK., .MIG., .MTOR., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .UBI., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway; B cell activation; Metabotropic glutamate receptor group I pathway; Inflammation mediated by chemokine and cytokine signaling pathway","PROTEIN KINASE C ALPHA TYPE; PROTEIN KINASE C BETA TYPE; PROTEIN KINASE C GAMMA TYPE","angiogenesis; apoptotic process; apoptotic signaling pathway; cell adhesion; desmosome assembly; histone modification; intracellular signal transduction; mitotic nuclear membrane disassembly; negative regulation of glial cell apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of bone resorption; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; post-translational protein modification; protein phosphorylation; regulation of mRNA stability; regulation of platelet aggregation; response to interleukin-1; adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium ion transport; cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; chromatin organization; immune system process; lipoprotein transport; negative regulation of glucose transmembrane transport; negative regulation of insulin receptor signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; positive regulation of B cell receptor signaling pathway; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of NF-kappaB transcription factor activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; regulation of glucose transmembrane transport; regulation of synaptic vesicle exocytosis; regulation of transcription by RNA polymerase II; signal transduction; chemical synaptic transmission; chemosensory behavior; innervation; learning or memory; long-term synaptic potentiation; negative regulation of neuron apoptotic process; negative regulation of proteasomal protein catabolic process; negative regulation of protein catabolic process; negative regulation of protein ubiquitination; positive regulation of mismatch repair; protein autophosphorylation; regulation of circadian rhythm; regulation of phagocytosis; regulation of response to food; response to morphine; response to pain; response to psychosocial stress; response to toxic substance; rhythmic process","ATP binding; calcium-dependent protein kinase C activity; enzyme binding; histone H3T6 kinase activity; integrin binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding; calcium channel regulator activity; chromatin binding; histone binding; nuclear androgen receptor binding; nuclear receptor coactivator activity; protein kinase C binding; protein serine/threonine/tyrosine kinase activity","alphav-beta3 integrin-PKCalpha complex; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane; mitochondrial membrane; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; calyx of Held; presynaptic cytosol; spectrin; cell projection; cell-cell junction; dendrite; neuron projection; postsynaptic cytosol; postsynaptic density; synapse; synaptic membrane","cAMP signaling / metabolism","protein kinase C alpha; protein kinase C beta; protein kinase C gamma","http://www.ncbi.nlm.nih.gov/gene/?term=5578, http://www.ncbi.nlm.nih.gov/gene/?term=5579, http://www.ncbi.nlm.nih.gov/gene/?term=5582","5578, 5579, 5582","NA, 18751, 18752","NA, 25023, 24681",null,null,null,"P17252, P05771, P05129","Q3TQ39, P68404, P63318","P05696, P68403, P63319","A0A8I3PUQ8, A0A8I3MFL8, A0A8I3MM53","A0A8W4F9E9, A0A5G2QM77","A0A1D5R985, A0A5F8AEL4, A0A5F8AQE3","GO:0035866; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0016020; GO:0031966; GO:0005739; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0044305; GO:0099523; GO:0008091; GO:0042995; GO:0005911; GO:0030425; GO:0043005; GO:0099524; GO:0014069; GO:0045202; GO:0097060","GO:0005524; GO:0004698; GO:0019899; GO:0035403; GO:0005178; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740; GO:0008270; GO:0005246; GO:0003682; GO:0042393; GO:0050681; GO:0030374; GO:0005080; GO:0004712","GO:0001525; GO:0006915; GO:0097190; GO:0007155; GO:0002159; GO:0016570; GO:0035556; GO:0007077; GO:0034351; GO:0018105; GO:0018107; GO:0016310; GO:0106071; GO:0045766; GO:0043536; GO:0045780; GO:0010613; GO:0045785; GO:0030335; GO:2000707; GO:0010595; GO:0001938; GO:0070374; GO:0031666; GO:0045651; GO:0045931; GO:0043687; GO:0006468; GO:0043488; GO:0090330; GO:0070555; GO:0002250; GO:0042113; GO:0050853; GO:0006816; GO:0006874; GO:0071322; GO:0006325; GO:0002376; GO:0042953; GO:0010829; GO:0046627; GO:0007207; GO:0050861; GO:0045893; GO:0043123; GO:0032024; GO:0051092; GO:0030949; GO:0099171; GO:0010827; GO:2000300; GO:0006357; GO:0007165; GO:0007268; GO:0007635; GO:0060384; GO:0007611; GO:0060291; GO:0043524; GO:1901799; GO:0042177; GO:0031397; GO:0032425; GO:0046777; GO:0042752; GO:0050764; GO:0032095; GO:0043278; GO:0048265; GO:1990911; GO:0009636; GO:0048511","PTHR24356:SF193; PTHR24356:SF158; PTHR24356:SF162","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9393|UniProtKB=P17252; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9395|UniProtKB=P05771; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9402|UniProtKB=P05129","P00027; P06959; P04385; P04374; P00042; P00056; P04391; P00002; P06664; P00021; P04394; P00047; P05911; P00005; P00018; P00003; P00019; P00057; P00006; P00010; P00041; P00031"]
["PKC beta",null,"PRKCB","80","ms",null,2,7,1,6,2.1,2,"# 1841",".ALZ., .ANG., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CSP., .DEV., .DI., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMU., .IMUF., .IMUR., .INFM., .INS., .MAPK., .MTOR., .NFKB., .NSCLC., .OP., .OPA., .OT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; B cell activation; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; Angiogenesis; EGF receptor signaling pathway; Metabotropic glutamate receptor group I pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C BETA TYPE","adaptive immune response; apoptotic process; B cell activation; B cell receptor signaling pathway; calcium ion transport; cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; chromatin organization; histone modification; immune system process; intracellular signal transduction; lipoprotein transport; mitotic nuclear membrane disassembly; negative regulation of glucose transmembrane transport; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; phosphorylation; positive regulation of angiogenesis; positive regulation of B cell receptor signaling pathway; positive regulation of DNA-templated transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of NF-kappaB transcription factor activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; post-translational protein modification; presynaptic modulation of chemical synaptic transmission; protein phosphorylation; regulation of glucose transmembrane transport; regulation of synaptic vesicle exocytosis; regulation of transcription by RNA polymerase II; signal transduction","ATP binding; calcium channel regulator activity; calcium-dependent protein kinase C activity; chromatin binding; histone binding; histone H3T6 kinase activity; kinase activity; metal ion binding; nuclear androgen receptor binding; nuclear receptor coactivator activity; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein kinase C binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding","calyx of Held; cytoplasm; cytosol; extracellular exosome; membrane; nucleoplasm; nucleus; plasma membrane; presynaptic cytosol; spectrin",null,"protein kinase C beta","http://www.ncbi.nlm.nih.gov/gene/?term=5579","5579","18751","25023",null,null,null,"P05771","P68404","P68403","A0A8I3MFL8",null,"A0A5F8AEL4","GO:0044305; GO:0005737; GO:0005829; GO:0070062; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0099523; GO:0008091","GO:0005524; GO:0005246; GO:0004698; GO:0003682; GO:0042393; GO:0035403; GO:0016301; GO:0046872; GO:0050681; GO:0030374; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0005080; GO:0106310; GO:0004674; GO:0016740; GO:0008270","GO:0002250; GO:0006915; GO:0042113; GO:0050853; GO:0006816; GO:0006874; GO:0071322; GO:0006325; GO:0016570; GO:0002376; GO:0035556; GO:0042953; GO:0007077; GO:0010829; GO:0046627; GO:0018105; GO:0007207; GO:0016310; GO:0045766; GO:0050861; GO:0045893; GO:0043123; GO:0032024; GO:0051092; GO:0030949; GO:0043687; GO:0099171; GO:0006468; GO:0010827; GO:2000300; GO:0006357; GO:0007165","PTHR24356:SF158","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9395|UniProtKB=P05771","P00027; P06959; P04385; P04374; P00042; P00010; P00056; P04391; P06664; P00021; P04394; P00005; P00018; P00041; P00003; P00031; P00019; P00057; P00006"]
["PKC delta",null,"PRKCD","78","ms",null,2,4,1,8,1,8,"# 1585",".ALZ., .ANG., .APH., .APO., .BCR., .CANCER., .CCKR., .CCP., .CCY., .CD., .CSP., .DDR., .DEV., .DI., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .IMFR., .IMUF., .IMUR., .INS., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; B cell activation; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C DELTA TYPE","activation of protein kinase activity; apoptotic process; B cell proliferation; cell chemotaxis; cell cycle; cellular response to angiotensin; cellular response to hydrogen peroxide; cellular response to hydroperoxide; cellular response to UV; cellular senescence; defense response to bacterium; Fc-gamma receptor signaling pathway involved in phagocytosis; immunoglobulin mediated immune response; intracellular signal transduction; intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of actin filament polymerization; negative regulation of filopodium assembly; negative regulation of glial cell apoptotic process; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of platelet aggregation; negative regulation of protein binding; neutrophil activation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of apoptotic signaling pathway; positive regulation of ceramide biosynthetic process; positive regulation of endodeoxyribonuclease activity; positive regulation of glucosylceramide catabolic process; positive regulation of phospholipid scramblase activity; positive regulation of protein dephosphorylation; positive regulation of protein import into nucleus; positive regulation of response to DNA damage stimulus; positive regulation of sphingomyelin catabolic process; positive regulation of superoxide anion generation; post-translational protein modification; protein phosphorylation; protein stabilization; regulation of actin cytoskeleton organization; regulation of ceramide biosynthetic process; regulation of mRNA stability; regulation of signaling receptor activity; signal transduction; termination of signal transduction","ATP binding; calcium-dependent protein kinase C activity; calcium-independent protein kinase C activity; enzyme activator activity; enzyme binding; insulin receptor substrate binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","azurophil granule lumen; cell-cell junction; cytoplasm; cytosol; endolysosome; endomembrane system; endoplasmic reticulum; extracellular exosome; extracellular region; membrane; mitochondrion; nuclear matrix; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane","cAMP signaling / metabolism","protein kinase C delta","http://www.ncbi.nlm.nih.gov/gene/?term=5580","5580","18753",null,null,null,null,"Q05655","P28867","A0A140UHX0","A0A8I3PZJ7","A0A287A287","A0A5F8ADY8","GO:0035578; GO:0005911; GO:0005737; GO:0005829; GO:0036019; GO:0012505; GO:0005783; GO:0070062; GO:0005576; GO:0016020; GO:0005739; GO:0016363; GO:0005654; GO:0005634; GO:0048471; GO:0005886","GO:0005524; GO:0004698; GO:0004699; GO:0008047; GO:0019899; GO:0043560; GO:0016301; GO:0046872; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0004697; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0032147; GO:0006915; GO:0042100; GO:0060326; GO:0007049; GO:1904385; GO:0070301; GO:0071447; GO:0034644; GO:0090398; GO:0042742; GO:0038096; GO:0016064; GO:0035556; GO:0008631; GO:0030837; GO:0051490; GO:0034351; GO:0050728; GO:0046627; GO:0043407; GO:0050732; GO:0090331; GO:0032091; GO:0042119; GO:0018105; GO:0018107; GO:0018108; GO:0016310; GO:2001235; GO:2000304; GO:0032079; GO:2000753; GO:1900163; GO:0035307; GO:0042307; GO:2001022; GO:2000755; GO:0032930; GO:0043687; GO:0006468; GO:0050821; GO:0032956; GO:2000303; GO:0043488; GO:0010469; GO:0007165; GO:0023021","PTHR24356:SF365","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9399|UniProtKB=Q05655","P00027; P06959; P04385; P04374; P00042; P00010; P00056; P04391; P00002; P06664; P00021; P04394; P00005; P00018; P00003; P00019; P00057; P00006"]
["PKC epsilon",null,"PRKCE","90","ms",null,2.1,2,1,8,8,2.1,"# 1586",".ALZ., .ANG., .APO., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .DRR., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .HIF., .IMU., .IMUF., .IMUR., .INFM., .INS., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TOLL., .UBI., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C EPSILON TYPE","apoptotic process; cell adhesion; cell cycle; cell division; cell-substrate adhesion; cellular response to ethanol; cellular response to hypoxia; cellular response to prostaglandin E stimulus; establishment of localization in cell; Fc-gamma receptor signaling pathway involved in phagocytosis; immune system process; insulin secretion; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; locomotory exploration behavior; macrophage activation involved in immune response; MAPK cascade; mucus secretion; negative regulation of protein ubiquitination; negative regulation of sodium ion transmembrane transporter activity; peptidyl-serine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell-substrate adhesion; positive regulation of cellular glucuronidation; positive regulation of cytokinesis; positive regulation of epithelial cell migration; positive regulation of fibroblast migration; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of lipid catabolic process; positive regulation of MAPK cascade; positive regulation of mucus secretion; positive regulation of protein localization to plasma membrane; positive regulation of synaptic transmission, GABAergic; positive regulation of wound healing; protein phosphorylation; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of lipid metabolic process; regulation of peptidyl-tyrosine phosphorylation; regulation of release of sequestered calcium ion into cytosol; response to morphine; signal transduction; synaptic transmission, GABAergic; TRAM-dependent toll-like receptor 4 signaling pathway","14-3-3 protein binding; actin monomer binding; ATP binding; calcium-dependent protein kinase C activity; calcium-independent protein kinase C activity; enzyme activator activity; enzyme binding; ethanol binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; signaling receptor activator activity; transferase activity","cell periphery; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; Golgi apparatus; intermediate filament cytoskeleton; intracellular membrane-bounded organelle; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; synapse","cAMP signaling / metabolism","protein kinase C epsilon","http://www.ncbi.nlm.nih.gov/gene/?term=5581","5581","18754",null,null,null,null,"Q02156","P16054","A0A0G2JXV8","A0A8I3PUK1","A0A287AHR4","A0A1D5QIW0","GO:0071944; GO:0005737; GO:0005856; GO:0005829; GO:0005783; GO:0005794; GO:0045111; GO:0043231; GO:0016020; GO:0005739; GO:0005634; GO:0048471; GO:0005886; GO:0045202","GO:0071889; GO:0003785; GO:0005524; GO:0004698; GO:0004699; GO:0008047; GO:0019899; GO:0035276; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0030546; GO:0016740","GO:0006915; GO:0007155; GO:0007049; GO:0051301; GO:0031589; GO:0071361; GO:0071456; GO:0071380; GO:0051649; GO:0038096; GO:0002376; GO:0030073; GO:0035556; GO:0031663; GO:0035641; GO:0002281; GO:0000165; GO:0070254; GO:0031397; GO:2000650; GO:0018105; GO:0016310; GO:0030838; GO:0010811; GO:2001031; GO:0032467; GO:0010634; GO:0010763; GO:0043123; GO:0032024; GO:0050996; GO:0043410; GO:0070257; GO:1903078; GO:0032230; GO:0090303; GO:0006468; GO:0061178; GO:0019216; GO:0050730; GO:0051279; GO:0043278; GO:0007165; GO:0051932; GO:0035669","PTHR24356:SF159","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9401|UniProtKB=Q02156","P00027; P06959; P04385; P04374; P00042; P00056; P04391; P00002; P06664; P00021; P04394; P00005; P00018; P00003; P00031; P00019; P00057; P00006"]
["PKC iota",null,"PRKCI","74","ms",null,2,2,2,2,1,2.1,"# 1874",".ALZ., .ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .HIPPO., .IMUF., .INS., .MIG., .NFKB., .NOTCH., .OP., .OPA., .OT., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway","PROTEIN KINASE C IOTA TYPE","actin filament organization; cell migration; cell-cell junction organization; cellular response to insulin stimulus; cytoskeleton organization; establishment of apical/basal cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; eye photoreceptor cell development; Golgi vesicle budding; intracellular signal transduction; membrane organization; negative regulation of apoptotic process; negative regulation of glial cell apoptotic process; negative regulation of neuron apoptotic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of endothelial cell apoptotic process; positive regulation of glial cell proliferation; positive regulation of glucose import; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of protein localization to plasma membrane; protein localization; protein phosphorylation; protein targeting to membrane; regulation of postsynaptic membrane neurotransmitter receptor levels; response to interleukin-1; response to peptide hormone; secretion; vesicle-mediated transport","ATP binding; calcium-dependent protein kinase C activity; kinase activity; metal ion binding; nucleotide binding; phospholipid binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","apical part of cell; apical plasma membrane; bicellular tight junction; brush border; cell leading edge; cytoplasm; cytosol; endosome; extracellular exosome; glutamatergic synapse; Golgi membrane; intercellular bridge; membrane; microtubule cytoskeleton; nucleoplasm; nucleus; PAR polarity complex; plasma membrane; Schaffer collateral - CA1 synapse; Schmidt-Lanterman incisure; tight junction",null,"protein kinase C iota","http://www.ncbi.nlm.nih.gov/gene/?term=5584","5584","18759","84006",null,null,"574352","P41743","Q62074","F1M7Y5","A0A8I3PGZ0","A0A286ZLS5","A0A1D5RJL1","GO:0045177; GO:0016324; GO:0005923; GO:0005903; GO:0031252; GO:0005737; GO:0005829; GO:0005768; GO:0070062; GO:0098978; GO:0000139; GO:0045171; GO:0016020; GO:0015630; GO:0005654; GO:0005634; GO:0120157; GO:0005886; GO:0098685; GO:0043220; GO:0070160","GO:0005524; GO:0004698; GO:0016301; GO:0046872; GO:0000166; GO:0005543; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740","GO:0007015; GO:0016477; GO:0045216; GO:0032869; GO:0007010; GO:0035089; GO:0045197; GO:0042462; GO:0048194; GO:0035556; GO:0061024; GO:0043066; GO:0034351; GO:0043524; GO:0018105; GO:0016310; GO:2000353; GO:0060252; GO:0046326; GO:0010976; GO:0051092; GO:0045747; GO:1903078; GO:0008104; GO:0006468; GO:0006612; GO:0099072; GO:0070555; GO:0043434; GO:0046903; GO:0016192","PTHR24356:SF214","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9404|UniProtKB=P41743","P00027; P04385; P04374; P00042; P00056; P04391; P00021; P04394; P00005; P00018; P00003; P00019; P00057"]
["PKC lambda",null,"PRKCI","74","ms",null,1,2,1,1,1.1000000000000001,1,"# 1876",".ALZ., .ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .HIPPO., .IMUF., .INS., .MIG., .NFKB., .NOTCH., .OP., .OPA., .OT., .PLAT., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway","PROTEIN KINASE C IOTA TYPE","actin filament organization; cell migration; cell-cell junction organization; cellular response to insulin stimulus; cytoskeleton organization; establishment of apical/basal cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; eye photoreceptor cell development; Golgi vesicle budding; intracellular signal transduction; membrane organization; negative regulation of apoptotic process; negative regulation of glial cell apoptotic process; negative regulation of neuron apoptotic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of endothelial cell apoptotic process; positive regulation of glial cell proliferation; positive regulation of glucose import; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of protein localization to plasma membrane; protein localization; protein phosphorylation; protein targeting to membrane; regulation of postsynaptic membrane neurotransmitter receptor levels; response to interleukin-1; response to peptide hormone; secretion; vesicle-mediated transport","ATP binding; calcium-dependent protein kinase C activity; kinase activity; metal ion binding; nucleotide binding; phospholipid binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","apical part of cell; apical plasma membrane; bicellular tight junction; brush border; cell leading edge; cytoplasm; cytosol; endosome; extracellular exosome; glutamatergic synapse; Golgi membrane; intercellular bridge; membrane; microtubule cytoskeleton; nucleoplasm; nucleus; PAR polarity complex; plasma membrane; Schaffer collateral - CA1 synapse; Schmidt-Lanterman incisure; tight junction",null,"protein kinase C iota","http://www.ncbi.nlm.nih.gov/gene/?term=5584","5584","18759","84006",null,null,"574352","P41743","Q62074","F1M7Y5","A0A8I3PGZ0","A0A286ZLS5","A0A1D5RJL1","GO:0045177; GO:0016324; GO:0005923; GO:0005903; GO:0031252; GO:0005737; GO:0005829; GO:0005768; GO:0070062; GO:0098978; GO:0000139; GO:0045171; GO:0016020; GO:0015630; GO:0005654; GO:0005634; GO:0120157; GO:0005886; GO:0098685; GO:0043220; GO:0070160","GO:0005524; GO:0004698; GO:0016301; GO:0046872; GO:0000166; GO:0005543; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740","GO:0007015; GO:0016477; GO:0045216; GO:0032869; GO:0007010; GO:0035089; GO:0045197; GO:0042462; GO:0048194; GO:0035556; GO:0061024; GO:0043066; GO:0034351; GO:0043524; GO:0018105; GO:0016310; GO:2000353; GO:0060252; GO:0046326; GO:0010976; GO:0051092; GO:0045747; GO:1903078; GO:0008104; GO:0006468; GO:0006612; GO:0099072; GO:0070555; GO:0043434; GO:0046903; GO:0016192","PTHR24356:SF214","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9404|UniProtKB=P41743","P00027; P04385; P04374; P00042; P00056; P04391; P00021; P04394; P00005; P00018; P00003; P00019; P00057"]
["PKC substrates - phospho","Ser","PRKCA","n.a.","rb",null,7,2,8,8,8,8,"BG/MP # 021",".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .MAPK., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Alpha adrenergic receptor signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiotensin II-stimulated signaling through G proteins and beta-arrestin; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C ALPHA TYPE","angiogenesis; apoptotic process; apoptotic signaling pathway; cell adhesion; desmosome assembly; histone modification; intracellular signal transduction; mitotic nuclear membrane disassembly; negative regulation of glial cell apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of bone resorption; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; post-translational protein modification; protein phosphorylation; regulation of mRNA stability; regulation of platelet aggregation; response to interleukin-1","ATP binding; calcium-dependent protein kinase C activity; enzyme binding; histone H3T6 kinase activity; integrin binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding","alphav-beta3 integrin-PKCalpha complex; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane; mitochondrial membrane; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane","cAMP signaling / metabolism","protein kinase C alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5578","5578",null,null,null,null,null,"P17252","Q3TQ39","P05696","A0A8I3PUQ8","A0A8W4F9E9","A0A1D5R985","GO:0035866; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0016020; GO:0031966; GO:0005739; GO:0005654; GO:0005634; GO:0048471; GO:0005886","GO:0005524; GO:0004698; GO:0019899; GO:0035403; GO:0005178; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740; GO:0008270","GO:0001525; GO:0006915; GO:0097190; GO:0007155; GO:0002159; GO:0016570; GO:0035556; GO:0007077; GO:0034351; GO:0018105; GO:0018107; GO:0016310; GO:0106071; GO:0045766; GO:0043536; GO:0045780; GO:0010613; GO:0045785; GO:0030335; GO:2000707; GO:0010595; GO:0001938; GO:0070374; GO:0031666; GO:0045651; GO:0045931; GO:0043687; GO:0006468; GO:0043488; GO:0090330; GO:0070555","PTHR24356:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9393|UniProtKB=P17252","P00027; P06959; P04385; P04374; P00042; P00056; P04391; P00002; P06664; P00021; P04394; P00047; P05911; P00005; P00018; P00003; P00019; P00057; P00006"]
["PKC theta",null,"PRKCQ","78","rb",null,4,2,1.1000000000000001,1,1,1,"# 1303",".ALZ., .ANG., .APH., .APO., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .IMFR., .IMU., .IMUF., .IMUR., .INS., .MIG., .NFKB., .OP., .OPA., .OT., .PLAT., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; T cell activation; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C THETA TYPE","axon guidance; CD4-positive, alpha-beta T cell proliferation; cell chemotaxis; Fc-epsilon receptor signaling pathway; immune system process; inflammatory response; intracellular signal transduction; membrane protein ectodomain proteolysis; negative regulation of insulin receptor signaling pathway; negative regulation of T cell apoptotic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of interleukin-17 production; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of T-helper 17 type immune response; positive regulation of T-helper 2 cell activation; protein phosphorylation; regulation of cell growth; regulation of DNA-templated transcription; regulation of platelet aggregation; T cell activation","ATP binding; calcium-dependent protein kinase C activity; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","aggresome; centriolar satellite; cytoplasm; cytosol; immunological synapse; membrane; plasma membrane","cAMP signaling / metabolism","protein kinase C theta","http://www.ncbi.nlm.nih.gov/gene/?term=5588","5588","18761",null,null,null,null,"Q04759","Q02111","A0A8I6A0B5","A0A8I3MIR2","A0A287A0E4","F7HC75","GO:0016235; GO:0034451; GO:0005737; GO:0005829; GO:0001772; GO:0016020; GO:0005886","GO:0005524; GO:0004698; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740","GO:0007411; GO:0035739; GO:0060326; GO:0038095; GO:0002376; GO:0006954; GO:0035556; GO:0006509; GO:0046627; GO:0070233; GO:0018105; GO:0016310; GO:2000563; GO:0032740; GO:0032743; GO:0032753; GO:0051092; GO:0050870; GO:0051973; GO:1904355; GO:0032212; GO:2000318; GO:2000570; GO:0006468; GO:0001558; GO:0006355; GO:0090330; GO:0042110","PTHR24356:SF181","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9410|UniProtKB=Q04759","P00027; P06959; P00053; P04385; P04374; P00042; P00056; P04391; P06664; P00021; P04394; P00005; P00018; P00003; P00019; P00057; P00006"]
["PKC theta",null,"PRKCQ","79","ms",null,2,1,"n/a","n/a","n/a","n/a","# 1875",".ALZ., .ANG., .APH., .APO., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .IMFR., .IMU., .IMUF., .IMUR., .INS., .MIG., .NFKB., .OP., .OPA., .OT., .PLAT., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; T cell activation; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C THETA TYPE","axon guidance; CD4-positive, alpha-beta T cell proliferation; cell chemotaxis; Fc-epsilon receptor signaling pathway; immune system process; inflammatory response; intracellular signal transduction; membrane protein ectodomain proteolysis; negative regulation of insulin receptor signaling pathway; negative regulation of T cell apoptotic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of interleukin-17 production; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of T-helper 17 type immune response; positive regulation of T-helper 2 cell activation; protein phosphorylation; regulation of cell growth; regulation of DNA-templated transcription; regulation of platelet aggregation; T cell activation","ATP binding; calcium-dependent protein kinase C activity; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","aggresome; centriolar satellite; cytoplasm; cytosol; immunological synapse; membrane; plasma membrane","cAMP signaling / metabolism","protein kinase C theta","http://www.ncbi.nlm.nih.gov/gene/?term=5588","5588","18761",null,null,null,null,"Q04759","Q02111","A0A8I6A0B5","A0A8I3MIR2","A0A287A0E4","F7HC75","GO:0016235; GO:0034451; GO:0005737; GO:0005829; GO:0001772; GO:0016020; GO:0005886","GO:0005524; GO:0004698; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740","GO:0007411; GO:0035739; GO:0060326; GO:0038095; GO:0002376; GO:0006954; GO:0035556; GO:0006509; GO:0046627; GO:0070233; GO:0018105; GO:0016310; GO:2000563; GO:0032740; GO:0032743; GO:0032753; GO:0051092; GO:0050870; GO:0051973; GO:1904355; GO:0032212; GO:2000318; GO:2000570; GO:0006468; GO:0001558; GO:0006355; GO:0090330; GO:0042110","PTHR24356:SF181","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9410|UniProtKB=Q04759","P00027; P06959; P00053; P04385; P04374; P00042; P00056; P04391; P06664; P00021; P04394; P00005; P00018; P00003; P00019; P00057; P00006"]
["PKC theta - phospho","Thr538","PRKCQ","79","rb",null,1,4,8,8,8,8,"# 3278",".ALZ., .ANG., .APH., .APO., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .IMFR., .IMU., .IMUF., .IMUR., .INS., .MIG., .NFKB., .OP., .OPA., .OT., .PLAT., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .TRASR., .VEGFS., .WNT.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; T cell activation; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; Angiogenesis; EGF receptor signaling pathway; Alzheimer disease-amyloid secretase pathway; Endothelin signaling pathway; Wnt signaling pathway; Apoptosis signaling pathway","PROTEIN KINASE C THETA TYPE","axon guidance; CD4-positive, alpha-beta T cell proliferation; cell chemotaxis; Fc-epsilon receptor signaling pathway; immune system process; inflammatory response; intracellular signal transduction; membrane protein ectodomain proteolysis; negative regulation of insulin receptor signaling pathway; negative regulation of T cell apoptotic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of interleukin-17 production; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of T-helper 17 type immune response; positive regulation of T-helper 2 cell activation; protein phosphorylation; regulation of cell growth; regulation of DNA-templated transcription; regulation of platelet aggregation; T cell activation","ATP binding; calcium-dependent protein kinase C activity; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","aggresome; centriolar satellite; cytoplasm; cytosol; immunological synapse; membrane; plasma membrane","cAMP signaling / metabolism","protein kinase C theta","http://www.ncbi.nlm.nih.gov/gene/?term=5588","5588","18761",null,null,null,null,"Q04759","Q02111","A0A8I6A0B5","A0A8I3MIR2","A0A287A0E4","F7HC75","GO:0016235; GO:0034451; GO:0005737; GO:0005829; GO:0001772; GO:0016020; GO:0005886","GO:0005524; GO:0004698; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0016740","GO:0007411; GO:0035739; GO:0060326; GO:0038095; GO:0002376; GO:0006954; GO:0035556; GO:0006509; GO:0046627; GO:0070233; GO:0018105; GO:0016310; GO:2000563; GO:0032740; GO:0032743; GO:0032753; GO:0051092; GO:0050870; GO:0051973; GO:1904355; GO:0032212; GO:2000318; GO:2000570; GO:0006468; GO:0001558; GO:0006355; GO:0090330; GO:0042110","PTHR24356:SF181","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9410|UniProtKB=Q04759","P00027; P06959; P00053; P04385; P04374; P00042; P00056; P04391; P06664; P00021; P04394; P00005; P00018; P00003; P00019; P00057; P00006"]
["PKG-1",null,"PRKG1","78","rb",null,6,2,6,2,2,2,"# 1577",".CCKR., .CCP., .CP., .CSP., .ENDO., .MIG., .OP., .OPA., .OT., .PLAT., .ST.","CCKR signaling map; Endothelin signaling pathway","SUBFAMILY NOT NAMED","actin cytoskeleton organization; cGMP-mediated signaling; collateral sprouting; dendrite development; forebrain development; metabolic process; negative regulation of platelet aggregation; negative regulation of smooth muscle contraction; negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular associated smooth muscle cell proliferation; neuron migration; phosphorylation; protein phosphorylation; regulation of GTPase activity; relaxation of vascular associated smooth muscle; signal transduction","ATP binding; calcium channel regulator activity; catalytic activity; cGMP binding; cGMP-dependent protein kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; Golgi apparatus; plasma membrane",null,"protein kinase cGMP-dependent 1","http://www.ncbi.nlm.nih.gov/gene/?term=5592","5592","19091",null,null,null,"703356","Q13976","P0C605",null,"A0A8I3PZC5","A0A8W4FPQ2","F7G3L7","GO:0005737; GO:0005829; GO:0005794; GO:0005886","GO:0005524; GO:0005246; GO:0003824; GO:0030553; GO:0004692; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0016740","GO:0030036; GO:0019934; GO:0048668; GO:0016358; GO:0030900; GO:0008152; GO:0090331; GO:0045986; GO:1904753; GO:1904706; GO:0001764; GO:0016310; GO:0006468; GO:0043087; GO:0060087; GO:0007165","PTHR24353:SF68","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9414|UniProtKB=Q13976","P06959; P00019"]
["PKM2 - phospho","Tyr105","PKM","60","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2844",".ANG., .CAMET., .CANCER., .CSP., .INS., .OP., .OPA., .OT., .SREME., .ST., .TRASR.","Pyruvate metabolism; Glycolysis","PYRUVATE KINASE PKM","canonical glycolysis; cellular response to insulin stimulus; glycolytic process; metabolic process; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cytoplasmic translation; positive regulation of sprouting angiogenesis; programmed cell death; regulation of translation","ATP binding; cadherin binding; catalytic activity; kinase activity; magnesium ion binding; metal ion binding; MHC class II protein complex binding; mRNA binding; nucleotide binding; potassium ion binding; protein binding; protein tyrosine kinase activity; pyruvate kinase activity; RNA binding; transferase activity","cilium; collagen-containing extracellular matrix; cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular vesicle; ficolin-1-rich granule lumen; mitochondrion; nucleus; rough endoplasmic reticulum; secretory granule lumen; vesicle",null,"pyruvate kinase M1/2","http://www.ncbi.nlm.nih.gov/gene/?term=5315","5315","18746",null,null,null,null,"P14618","P52480","M0RD14","A0A8P0NPE2","A0A286ZI36","A0A1D5R3F4","GO:0005929; GO:0062023; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1903561; GO:1904813; GO:0005739; GO:0005634; GO:0005791; GO:0034774; GO:0031982","GO:0005524; GO:0045296; GO:0003824; GO:0016301; GO:0000287; GO:0046872; GO:0023026; GO:0003729; GO:0000166; GO:0030955; GO:0005515; GO:0004713; GO:0004743; GO:0003723; GO:0016740","GO:0061621; GO:0032869; GO:0006096; GO:0008152; GO:0018108; GO:0016310; GO:2000767; GO:1903672; GO:0012501; GO:0006417","PTHR11817:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9021|UniProtKB=P14618","P02772; P00024"]
["PKM2 (Pyruvate kinase M2)",null,"PKM","60","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2843",".ANG., .CAMET., .CANCER., .CSP., .INS., .OP., .OPA., .OT., .SREME., .ST., .TRASR.","Pyruvate metabolism; Glycolysis","PYRUVATE KINASE PKM","canonical glycolysis; cellular response to insulin stimulus; glycolytic process; metabolic process; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cytoplasmic translation; positive regulation of sprouting angiogenesis; programmed cell death; regulation of translation","ATP binding; cadherin binding; catalytic activity; kinase activity; magnesium ion binding; metal ion binding; MHC class II protein complex binding; mRNA binding; nucleotide binding; potassium ion binding; protein binding; protein tyrosine kinase activity; pyruvate kinase activity; RNA binding; transferase activity","cilium; collagen-containing extracellular matrix; cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular vesicle; ficolin-1-rich granule lumen; mitochondrion; nucleus; rough endoplasmic reticulum; secretory granule lumen; vesicle",null,"pyruvate kinase M1/2","http://www.ncbi.nlm.nih.gov/gene/?term=5315","5315","18746",null,null,null,null,"P14618","P52480","M0RD14","A0A8P0NPE2","A0A286ZI36","A0A1D5R3F4","GO:0005929; GO:0062023; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1903561; GO:1904813; GO:0005739; GO:0005634; GO:0005791; GO:0034774; GO:0031982","GO:0005524; GO:0045296; GO:0003824; GO:0016301; GO:0000287; GO:0046872; GO:0023026; GO:0003729; GO:0000166; GO:0030955; GO:0005515; GO:0004713; GO:0004743; GO:0003723; GO:0016740","GO:0061621; GO:0032869; GO:0006096; GO:0008152; GO:0018108; GO:0016310; GO:2000767; GO:1903672; GO:0012501; GO:0006417","PTHR11817:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9021|UniProtKB=P14618","P02772; P00024"]
["PKN1",null,"PKN1","120","rb",null,1.1000000000000001,2,8,8,8,8,"# 1024",".ALZ., .APO., .BCR., .CD., .CSP., .DI., .IMUF., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Muscarinic acetylcholine receptor 1 and 3 signaling pathway; Alzheimer disease-amyloid secretase pathway","SERINE/THREONINE-PROTEIN KINASE N1","B cell apoptotic process; B cell homeostasis; chromatin organization; epithelial cell migration; histone modification; hyperosmotic response; intracellular signal transduction; negative regulation of B cell proliferation; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; peptidyl-serine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; post-translational protein modification; protein phosphorylation; regulation of androgen receptor signaling pathway; regulation of cell motility; regulation of germinal center formation; regulation of immunoglobulin production; regulation of transcription by RNA polymerase II; renal system process; signal transduction; spleen development","ATP binding; calcium-dependent protein kinase C activity; chromatin binding; histone binding; histone deacetylase binding; histone H3T11 kinase activity; kinase activity; nuclear androgen receptor binding; nuclear receptor coactivator activity; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein kinase C binding; protein serine kinase activity; protein serine/threonine kinase activity; small GTPase binding; transferase activity","cleavage furrow; cytoplasm; cytoplasmic vesicle; cytosol; endosome; membrane; midbody; nucleoplasm; nucleus; plasma membrane; protein-containing complex","Cell-cell interaction","protein kinase N1","http://www.ncbi.nlm.nih.gov/gene/?term=5585","5585","320795","29355",null,null,null,"Q16512","P70268","Q63433","A0A8P0SKN6","A0A287AYN9","A0A1D5QRX5","GO:0032154; GO:0005737; GO:0031410; GO:0005829; GO:0005768; GO:0016020; GO:0030496; GO:0005654; GO:0005634; GO:0005886; GO:0032991","GO:0005524; GO:0004698; GO:0003682; GO:0042393; GO:0042826; GO:0035402; GO:0016301; GO:0050681; GO:0030374; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0005080; GO:0106310; GO:0004674; GO:0031267; GO:0016740","GO:0001783; GO:0001782; GO:0006325; GO:0010631; GO:0016570; GO:0006972; GO:0035556; GO:0030889; GO:0006469; GO:0001933; GO:0018105; GO:0016310; GO:0045893; GO:0043687; GO:0006468; GO:0060765; GO:2000145; GO:0002634; GO:0002637; GO:0006357; GO:0003014; GO:0007165; GO:0048536","PTHR24356:SF246","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9405|UniProtKB=Q16512","P00042; P00003"]
["PKR",null,"EIF2AK2","67","rb",null,2,4,8,8,8,8,"# 1205",".ALZ., .APO., .CCP., .CD., .CP., .CSP., .DI., .IIR., .IMU., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .VIR.","Apoptosis signaling pathway","INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE","cellular response to amino acid starvation; defense response to virus; endoplasmic reticulum unfolded protein response; immune system process; innate immune response; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; regulation of hematopoietic progenitor cell differentiation; regulation of hematopoietic stem cell differentiation; regulation of hematopoietic stem cell proliferation; regulation of NLRP3 inflammasome complex assembly; regulation of translational initiation by eIF2 alpha phosphorylation; response to interferon-alpha; response to virus; translation","ATP binding; double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase regulator activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; RNA binding; transferase activity","cytoplasm; cytosol; membrane; nucleus; perinuclear region of cytoplasm; ribosome","Translational control","eukaryotic translation initiation factor 2 alpha kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5610","5610","19106",null,"611397",null,null,"P19525","Q03963","A0A0G2K100","Q2KM13",null,"A0A1D5QPP2","GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:0048471; GO:0005840","GO:0005524; GO:0003725; GO:0004694; GO:0042802; GO:0016301; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019888; GO:0106310; GO:0004674; GO:0004713; GO:0003723; GO:0016740","GO:0034198; GO:0051607; GO:0030968; GO:0002376; GO:0045087; GO:0043066; GO:0008285; GO:0033689; GO:0017148; GO:0045071; GO:0018108; GO:0016310; GO:0032722; GO:0001819; GO:0043410; GO:0051092; GO:1901224; GO:0032874; GO:0046777; GO:0006468; GO:1901532; GO:1902036; GO:1902033; GO:1900225; GO:0010998; GO:0035455; GO:0009615; GO:0006412","PTHR11042:SF163","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9437|UniProtKB=P19525","P00006"]
["PKR - phospho","Thr446","EIF2AK2","62","rb",null,2,6,2,2,2,2,"# 0265",".ALZ., .APO., .CCP., .CD., .CP., .CSP., .DI., .IIR., .IMU., .IMUF., .IMUR., .MAPK., .NFKB., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .VIR.","Apoptosis signaling pathway","INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE","cellular response to amino acid starvation; defense response to virus; endoplasmic reticulum unfolded protein response; immune system process; innate immune response; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; regulation of hematopoietic progenitor cell differentiation; regulation of hematopoietic stem cell differentiation; regulation of hematopoietic stem cell proliferation; regulation of NLRP3 inflammasome complex assembly; regulation of translational initiation by eIF2 alpha phosphorylation; response to interferon-alpha; response to virus; translation","ATP binding; double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase regulator activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; RNA binding; transferase activity","cytoplasm; cytosol; membrane; nucleus; perinuclear region of cytoplasm; ribosome","Translational control","eukaryotic translation initiation factor 2 alpha kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=5610","5610","19106",null,"611397",null,null,"P19525","Q03963","A0A0G2K100","Q2KM13",null,"A0A1D5QPP2","GO:0005737; GO:0005829; GO:0016020; GO:0005634; GO:0048471; GO:0005840","GO:0005524; GO:0003725; GO:0004694; GO:0042802; GO:0016301; GO:0004715; GO:0000166; GO:0005515; GO:0004672; GO:0019888; GO:0106310; GO:0004674; GO:0004713; GO:0003723; GO:0016740","GO:0034198; GO:0051607; GO:0030968; GO:0002376; GO:0045087; GO:0043066; GO:0008285; GO:0033689; GO:0017148; GO:0045071; GO:0018108; GO:0016310; GO:0032722; GO:0001819; GO:0043410; GO:0051092; GO:1901224; GO:0032874; GO:0046777; GO:0006468; GO:1901532; GO:1902036; GO:1902033; GO:1900225; GO:0010998; GO:0035455; GO:0009615; GO:0006412","PTHR11042:SF163","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9437|UniProtKB=P19525","P00006"]
["PLA2G5",null,"PLA2G5","16","rb",null,7,6,"n/a","n/a","n/a","n/a","# 1619",".CSP., .MAPK., .RAS., .RTK.",null,"PHOSPHOLIPASE A2 GROUP V","arachidonic acid secretion; cardiolipin acyl-chain remodeling; fatty acid metabolic process; leukotriene biosynthetic process; lipid catabolic process; lipid metabolic process; low-density lipoprotein particle remodeling; phagocytosis; phagosome-lysosome fusion; phosphatidylcholine catabolic process; phosphatidylcholine metabolic process; phospholipid catabolic process; phospholipid metabolic process; positive regulation of antifungal innate immune response; positive regulation of ERK1 and ERK2 cascade; positive regulation of immune complex clearance by monocytes and macrophages; positive regulation of macrophage derived foam cell differentiation; positive regulation of opsonization; positive regulation of phagocytosis; positive regulation of phagosome maturation; positive regulation of phospholipase activity","calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-independent phospholipase A2 activity; hydrolase activity; metal ion binding; phospholipase A2 activity; phospholipid binding","cytoplasmic vesicle; early phagosome; endosome; extracellular region; Golgi apparatus; membrane; phagocytic vesicle; phagolysosome; plasma membrane; recycling endosome","Phospholipases / not assigned phospholipase","phospholipase A2 group V","http://www.ncbi.nlm.nih.gov/gene/?term=5322","5322","18784","29354",null,null,null,"P39877","Q6GTW1","P51433","A0A8I3MJ83",null,null,"GO:0031410; GO:0032009; GO:0005768; GO:0005576; GO:0005794; GO:0016020; GO:0045335; GO:0032010; GO:0005886; GO:0055037","GO:0005509; GO:0047498; GO:0047499; GO:0016787; GO:0046872; GO:0004623; GO:0005543","GO:0050482; GO:0035965; GO:0006631; GO:0019370; GO:0016042; GO:0006629; GO:0034374; GO:0006909; GO:0090385; GO:0034638; GO:0046470; GO:0009395; GO:0006644; GO:1905036; GO:0070374; GO:0090265; GO:0010744; GO:1903028; GO:0050766; GO:1905164; GO:0010518","PTHR11716:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9038|UniProtKB=P39877"]
["PLC gamma 1",null,"PLCG1","155","rb",null,1,2,2,8,1,2,"# 2066",".ANG., .CANCER., .CANPTHW., .CCKR., .CCP., .CP., .CSP., .CUR., .D200., .D300., .DRAS., .EGFR., .FGFR., .GLI., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .VEGFS.","CCKR signaling map; T cell activation; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Axon guidance mediated by netrin; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1","calcium-mediated signaling; cell migration; cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; Fc-epsilon receptor signaling pathway; in utero embryonic development; intracellular signal transduction; lipid catabolic process; lipid metabolic process; modulation of chemical synaptic transmission; negative regulation of inflammatory response to antigenic stimulus; phosphatidylinositol metabolic process; phospholipid catabolic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell apoptotic process; positive regulation of epithelial cell migration; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of vascular endothelial cell proliferation; response to stimulus; signal transduction; T cell receptor signaling pathway","calcium ion binding; calcium-dependent phospholipase C activity; glutamate receptor binding; hydrolase activity; metal ion binding; neurotrophin TRKA receptor binding; phosphatidylinositol phospholipase C activity; phospholipase C activity; phosphoric diester hydrolase activity; protein binding; protein kinase binding; receptor tyrosine kinase binding","cell projection; cell-cell junction; COP9 signalosome; cytoplasm; cytosol; glutamatergic synapse; lamellipodium; plasma membrane; ruffle; ruffle membrane; Schaffer collateral - CA1 synapse","cAMP signaling / metabolism","phospholipase C gamma 1","http://www.ncbi.nlm.nih.gov/gene/?term=5335","5335","18803",null,null,null,"697069","P19174","Q62077","A0A8I6ACY2","A0A8I3SCI7","A0A287BD27","A0A1D5R8E9","GO:0042995; GO:0005911; GO:0008180; GO:0005737; GO:0005829; GO:0098978; GO:0030027; GO:0005886; GO:0001726; GO:0032587; GO:0098685","GO:0005509; GO:0050429; GO:0035254; GO:0016787; GO:0046872; GO:0005168; GO:0004435; GO:0004629; GO:0008081; GO:0005515; GO:0019901; GO:0030971","GO:0019722; GO:0016477; GO:0071364; GO:0007173; GO:0038095; GO:0001701; GO:0035556; GO:0016042; GO:0006629; GO:0050804; GO:0002862; GO:0046488; GO:0009395; GO:0045766; GO:0043536; GO:2000353; GO:0010634; GO:0051281; GO:1905564; GO:0050896; GO:0007165; GO:0050852","PTHR10336:SF173","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9065|UniProtKB=P19174","P06959; P00053; P04385; P04374; P00009; P00056; P04391; P00021; P04394; P00047; P00005; P00018; P00031"]
["PLC gamma 1 - phospho","Ser1248","PLCG1","150","rb",null,1,1.1000000000000001,"n/a","n/a","n/a","n/a","# 2379",".ANG., .CANCER., .CANPTHW., .CCKR., .CCP., .CP., .CSP., .CUR., .D200., .D300., .DRAS., .EGFR., .FGFR., .GLI., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .VEGFS.","CCKR signaling map; T cell activation; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Axon guidance mediated by netrin; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1","calcium-mediated signaling; cell migration; cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; Fc-epsilon receptor signaling pathway; in utero embryonic development; intracellular signal transduction; lipid catabolic process; lipid metabolic process; modulation of chemical synaptic transmission; negative regulation of inflammatory response to antigenic stimulus; phosphatidylinositol metabolic process; phospholipid catabolic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell apoptotic process; positive regulation of epithelial cell migration; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of vascular endothelial cell proliferation; response to stimulus; signal transduction; T cell receptor signaling pathway","calcium ion binding; calcium-dependent phospholipase C activity; glutamate receptor binding; hydrolase activity; metal ion binding; neurotrophin TRKA receptor binding; phosphatidylinositol phospholipase C activity; phospholipase C activity; phosphoric diester hydrolase activity; protein binding; protein kinase binding; receptor tyrosine kinase binding","cell projection; cell-cell junction; COP9 signalosome; cytoplasm; cytosol; glutamatergic synapse; lamellipodium; plasma membrane; ruffle; ruffle membrane; Schaffer collateral - CA1 synapse",null,"phospholipase C gamma 1","http://www.ncbi.nlm.nih.gov/gene/?term=5335","5335","18803",null,null,null,"697069","P19174","Q62077","A0A8I6ACY2","A0A8I3SCI7","A0A287BD27","A0A1D5R8E9","GO:0042995; GO:0005911; GO:0008180; GO:0005737; GO:0005829; GO:0098978; GO:0030027; GO:0005886; GO:0001726; GO:0032587; GO:0098685","GO:0005509; GO:0050429; GO:0035254; GO:0016787; GO:0046872; GO:0005168; GO:0004435; GO:0004629; GO:0008081; GO:0005515; GO:0019901; GO:0030971","GO:0019722; GO:0016477; GO:0071364; GO:0007173; GO:0038095; GO:0001701; GO:0035556; GO:0016042; GO:0006629; GO:0050804; GO:0002862; GO:0046488; GO:0009395; GO:0045766; GO:0043536; GO:2000353; GO:0010634; GO:0051281; GO:1905564; GO:0050896; GO:0007165; GO:0050852","PTHR10336:SF173","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9065|UniProtKB=P19174","P06959; P00053; P04385; P04374; P00009; P00056; P04391; P00021; P04394; P00047; P00005; P00018; P00031"]
["PLC gamma 1 - phospho","Tyr1245","PLCG1","150","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0221",".ANG., .CANCER., .CANPTHW., .CCKR., .CCP., .CP., .CSP., .EGFR., .FGFR., .GLI., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .VEGFS.","CCKR signaling map; T cell activation; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Axon guidance mediated by netrin; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1","calcium-mediated signaling; cell migration; cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; Fc-epsilon receptor signaling pathway; in utero embryonic development; intracellular signal transduction; lipid catabolic process; lipid metabolic process; modulation of chemical synaptic transmission; negative regulation of inflammatory response to antigenic stimulus; phosphatidylinositol metabolic process; phospholipid catabolic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell apoptotic process; positive regulation of epithelial cell migration; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of vascular endothelial cell proliferation; response to stimulus; signal transduction; T cell receptor signaling pathway","calcium ion binding; calcium-dependent phospholipase C activity; glutamate receptor binding; hydrolase activity; metal ion binding; neurotrophin TRKA receptor binding; phosphatidylinositol phospholipase C activity; phospholipase C activity; phosphoric diester hydrolase activity; protein binding; protein kinase binding; receptor tyrosine kinase binding","cell projection; cell-cell junction; COP9 signalosome; cytoplasm; cytosol; glutamatergic synapse; lamellipodium; plasma membrane; ruffle; ruffle membrane; Schaffer collateral - CA1 synapse","cAMP signaling / metabolism","phospholipase C gamma 1","http://www.ncbi.nlm.nih.gov/gene/?term=5335","5335","18803",null,null,null,"697069","P19174","Q62077","A0A8I6ACY2","A0A8I3SCI7","A0A287BD27","A0A1D5R8E9","GO:0042995; GO:0005911; GO:0008180; GO:0005737; GO:0005829; GO:0098978; GO:0030027; GO:0005886; GO:0001726; GO:0032587; GO:0098685","GO:0005509; GO:0050429; GO:0035254; GO:0016787; GO:0046872; GO:0005168; GO:0004435; GO:0004629; GO:0008081; GO:0005515; GO:0019901; GO:0030971","GO:0019722; GO:0016477; GO:0071364; GO:0007173; GO:0038095; GO:0001701; GO:0035556; GO:0016042; GO:0006629; GO:0050804; GO:0002862; GO:0046488; GO:0009395; GO:0045766; GO:0043536; GO:2000353; GO:0010634; GO:0051281; GO:1905564; GO:0050896; GO:0007165; GO:0050852","PTHR10336:SF173","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9065|UniProtKB=P19174","P06959; P00053; P04385; P04374; P00009; P00056; P04391; P00021; P04394; P00047; P00005; P00018; P00031"]
["PLC gamma 1 - phospho","Tyr783","PLCG1","155","rb",null,4,4,"n/a","n/a","n/a","n/a","TK # 088",".ANG., .CANCER., .CANPTHW., .CCKR., .CCP., .CP., .CSP., .CUR., .D200., .D300., .DRAS., .EGFR., .FGFR., .GLI., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .VEGFS.","CCKR signaling map; T cell activation; Histamine H1 receptor mediated signaling pathway; 5HT2 type receptor mediated signaling pathway; Axon guidance mediated by netrin; VEGF signaling pathway; Oxytocin receptor mediated signaling pathway; FGF signaling pathway; Thyrotropin-releasing hormone receptor signaling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1","calcium-mediated signaling; cell migration; cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; Fc-epsilon receptor signaling pathway; in utero embryonic development; intracellular signal transduction; lipid catabolic process; lipid metabolic process; modulation of chemical synaptic transmission; negative regulation of inflammatory response to antigenic stimulus; phosphatidylinositol metabolic process; phospholipid catabolic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell apoptotic process; positive regulation of epithelial cell migration; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of vascular endothelial cell proliferation; response to stimulus; signal transduction; T cell receptor signaling pathway","calcium ion binding; calcium-dependent phospholipase C activity; glutamate receptor binding; hydrolase activity; metal ion binding; neurotrophin TRKA receptor binding; phosphatidylinositol phospholipase C activity; phospholipase C activity; phosphoric diester hydrolase activity; protein binding; protein kinase binding; receptor tyrosine kinase binding","cell projection; cell-cell junction; COP9 signalosome; cytoplasm; cytosol; glutamatergic synapse; lamellipodium; plasma membrane; ruffle; ruffle membrane; Schaffer collateral - CA1 synapse","cAMP signaling / metabolism","phospholipase C gamma 1","http://www.ncbi.nlm.nih.gov/gene/?term=5335","5335","18803",null,null,null,"697069","P19174","Q62077","A0A8I6ACY2","A0A8I3SCI7","A0A287BD27","A0A1D5R8E9","GO:0042995; GO:0005911; GO:0008180; GO:0005737; GO:0005829; GO:0098978; GO:0030027; GO:0005886; GO:0001726; GO:0032587; GO:0098685","GO:0005509; GO:0050429; GO:0035254; GO:0016787; GO:0046872; GO:0005168; GO:0004435; GO:0004629; GO:0008081; GO:0005515; GO:0019901; GO:0030971","GO:0019722; GO:0016477; GO:0071364; GO:0007173; GO:0038095; GO:0001701; GO:0035556; GO:0016042; GO:0006629; GO:0050804; GO:0002862; GO:0046488; GO:0009395; GO:0045766; GO:0043536; GO:2000353; GO:0010634; GO:0051281; GO:1905564; GO:0050896; GO:0007165; GO:0050852","PTHR10336:SF173","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9065|UniProtKB=P19174","P06959; P00053; P04385; P04374; P00009; P00056; P04391; P00021; P04394; P00047; P00005; P00018; P00031"]
["PLK1",null,"PLK1","62","rb",null,2,4,8,8,8,8,"# 1520",".APO., .CCP., .CCY., .CD., .CP., .CSP., .FOXO., .OP., .OPA., .OT., .ST., .TRASR., .UBI.",null,"SERINE/THREONINE-PROTEIN KINASE PLK1","cell cycle; cell division; centrosome cycle; establishment of mitotic spindle orientation; establishment of protein localization; female meiosis chromosome segregation; G2/M transition of mitotic cell cycle; homologous chromosome segregation; microtubule bundle formation; mitotic cell cycle; mitotic chromosome condensation; mitotic cytokinesis; mitotic G2 DNA damage checkpoint signaling; mitotic nuclear membrane disassembly; mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription by RNA polymerase II; nuclear membrane disassembly; peptidyl-serine phosphorylation; phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to nucleus; positive regulation of proteolysis; positive regulation of ubiquitin protein ligase activity; positive regulation of ubiquitin-protein transferase activity; protein destabilization; protein localization to chromatin; protein localization to nuclear envelope; protein localization to organelle; protein phosphorylation; protein ubiquitination; regulation of anaphase-promoting complex-dependent catabolic process; regulation of cell cycle; regulation of cytokinesis; regulation of mitotic cell cycle; regulation of mitotic cell cycle phase transition; regulation of mitotic metaphase/anaphase transition; regulation of mitotic spindle assembly; regulation of protein binding; regulation of protein localization to cell cortex; sister chromatid cohesion; synaptonemal complex disassembly","anaphase-promoting complex binding; ATP binding; identical protein binding; kinase activity; magnesium ion binding; microtubule binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","centriolar satellite; centriole; centrosome; chromatin; chromosome; chromosome, centromeric region; condensed chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; kinetochore; microtubule cytoskeleton; microtubule organizing center; midbody; mitotic spindle pole; nucleoplasm; nucleus; outer kinetochore; spindle; spindle microtubule; spindle midzone; spindle pole; synaptonemal complex","Cell cycle control","polo like kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5347","5347","18817",null,"489971",null,"697686","P53350","Q07832","A0A140TAD2","A0A8I3MIN2","I3LII4","F7HSC1","GO:0034451; GO:0005814; GO:0005813; GO:0000785; GO:0005694; GO:0000775; GO:0000779; GO:0005737; GO:0005856; GO:0005829; GO:0000776; GO:0015630; GO:0005815; GO:0030496; GO:0097431; GO:0005654; GO:0005634; GO:0000940; GO:0005819; GO:0005876; GO:0051233; GO:0000922; GO:0000795","GO:0010997; GO:0005524; GO:0042802; GO:0016301; GO:0000287; GO:0008017; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0051301; GO:0007098; GO:0000132; GO:0045184; GO:0016321; GO:0000086; GO:0045143; GO:0001578; GO:0000278; GO:0007076; GO:0000281; GO:0007095; GO:0007077; GO:0000070; GO:0007094; GO:0007052; GO:0043066; GO:0045736; GO:0000122; GO:0051081; GO:0018105; GO:0016310; GO:0010800; GO:0032436; GO:1900182; GO:0045862; GO:1904668; GO:0051443; GO:0031648; GO:0071168; GO:0090435; GO:0033365; GO:0006468; GO:0016567; GO:1905784; GO:0051726; GO:0032465; GO:0007346; GO:1901990; GO:0030071; GO:1901673; GO:0043393; GO:1904776; GO:0007062; GO:0070194","PTHR24345:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9077|UniProtKB=P53350"]
["PLK1 - phospho","Thr210","PLK1","62","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1023",".APO., .CCP., .CCY., .CD., .CP., .CSP., .FOXO., .OP., .OPA., .OT., .ST., .TRASR., .UBI.",null,"SERINE/THREONINE-PROTEIN KINASE PLK1","cell cycle; cell division; centrosome cycle; establishment of mitotic spindle orientation; establishment of protein localization; female meiosis chromosome segregation; G2/M transition of mitotic cell cycle; homologous chromosome segregation; microtubule bundle formation; mitotic cell cycle; mitotic chromosome condensation; mitotic cytokinesis; mitotic G2 DNA damage checkpoint signaling; mitotic nuclear membrane disassembly; mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription by RNA polymerase II; nuclear membrane disassembly; peptidyl-serine phosphorylation; phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein localization to nucleus; positive regulation of proteolysis; positive regulation of ubiquitin protein ligase activity; positive regulation of ubiquitin-protein transferase activity; protein destabilization; protein localization to chromatin; protein localization to nuclear envelope; protein localization to organelle; protein phosphorylation; protein ubiquitination; regulation of anaphase-promoting complex-dependent catabolic process; regulation of cell cycle; regulation of cytokinesis; regulation of mitotic cell cycle; regulation of mitotic cell cycle phase transition; regulation of mitotic metaphase/anaphase transition; regulation of mitotic spindle assembly; regulation of protein binding; regulation of protein localization to cell cortex; sister chromatid cohesion; synaptonemal complex disassembly","anaphase-promoting complex binding; ATP binding; identical protein binding; kinase activity; magnesium ion binding; microtubule binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","centriolar satellite; centriole; centrosome; chromatin; chromosome; chromosome, centromeric region; condensed chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; kinetochore; microtubule cytoskeleton; microtubule organizing center; midbody; mitotic spindle pole; nucleoplasm; nucleus; outer kinetochore; spindle; spindle microtubule; spindle midzone; spindle pole; synaptonemal complex","Cell cycle control","polo like kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=5347","5347","18817",null,"489971",null,"697686","P53350","Q07832","A0A140TAD2","A0A8I3MIN2","I3LII4","F7HSC1","GO:0034451; GO:0005814; GO:0005813; GO:0000785; GO:0005694; GO:0000775; GO:0000779; GO:0005737; GO:0005856; GO:0005829; GO:0000776; GO:0015630; GO:0005815; GO:0030496; GO:0097431; GO:0005654; GO:0005634; GO:0000940; GO:0005819; GO:0005876; GO:0051233; GO:0000922; GO:0000795","GO:0010997; GO:0005524; GO:0042802; GO:0016301; GO:0000287; GO:0008017; GO:0000166; GO:0005515; GO:0004672; GO:0019901; GO:0106310; GO:0004674; GO:0016740","GO:0007049; GO:0051301; GO:0007098; GO:0000132; GO:0045184; GO:0016321; GO:0000086; GO:0045143; GO:0001578; GO:0000278; GO:0007076; GO:0000281; GO:0007095; GO:0007077; GO:0000070; GO:0007094; GO:0007052; GO:0043066; GO:0045736; GO:0000122; GO:0051081; GO:0018105; GO:0016310; GO:0010800; GO:0032436; GO:1900182; GO:0045862; GO:1904668; GO:0051443; GO:0031648; GO:0071168; GO:0090435; GO:0033365; GO:0006468; GO:0016567; GO:1905784; GO:0051726; GO:0032465; GO:0007346; GO:1901990; GO:0030071; GO:1901673; GO:0043393; GO:1904776; GO:0007062; GO:0070194","PTHR24345:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9077|UniProtKB=P53350"]
["PON3",null,"PON3","40","ms",null,2,2,1.1000000000000001,7,2,2.1,"# 1867",".DRR., .OP., .OT.",null,"SERUM PARAOXONASE/LACTONASE 3","aromatic compound catabolic process; carboxylic acid catabolic process; coumarin catabolic process; establishment of localization in cell; negative regulation of superoxide anion generation; phenylacetate catabolic process; renal sodium ion transport; response to toxic substance","3,4-dihydrocoumarin hydrolase activity; acyl-L-homoserine-lactone lactonohydrolase activity; aryldialkylphosphatase activity; arylesterase activity; hydrolase activity; metal ion binding; protein homodimerization activity","endoplasmic reticulum membrane; extracellular exosome; extracellular region; extracellular space; intracellular membrane-bounded organelle",null,"paraoxonase 3","http://www.ncbi.nlm.nih.gov/gene/?term=5446","5446","269823",null,null,null,"699236","Q15166","Q62087","A0A8I5ZKN0","A0A8I3PAS3","A0A5K1VCF0","F7H7I9","GO:0005789; GO:0070062; GO:0005576; GO:0005615; GO:0043231","GO:0018733; GO:0102007; GO:0004063; GO:0004064; GO:0016787; GO:0046872; GO:0042803","GO:0019439; GO:0046395; GO:0046226; GO:0051649; GO:0032929; GO:0010124; GO:0003096; GO:0009636","PTHR11799:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9206|UniProtKB=Q15166"]
["Pontin/RUVBL1",null,"RUVBL1","50","rb",null,1,1.1000000000000001,8,8,8,8,"# 1634",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .DEV., .DREP., .OP., .OT., .TRASR., .WNT.",null,"RUVB-LIKE 1","box C/D snoRNP assembly; cell cycle; cell division; cellular response to DNA damage stimulus; chromatin organization; chromatin remodeling; chromosome organization; DNA duplex unwinding; DNA recombination; DNA repair; histone acetylation; histone H2A acetylation; histone H4 acetylation; positive regulation of canonical Wnt signaling pathway; positive regulation of DNA repair; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair via homologous recombination; positive regulation of telomerase RNA localization to Cajal body; positive regulation of telomere maintenance in response to DNA damage; protein stabilization; regulation of apoptotic process; regulation of cell cycle; regulation of chromosome organization; regulation of DNA repair; regulation of DNA replication; regulation of DNA strand elongation; regulation of DNA-templated transcription; regulation of double-strand break repair; regulation of embryonic development; regulation of transcription by RNA polymerase II; spermatogenesis; telomere maintenance","ADP binding; ATP binding; ATP hydrolysis activity; ATPase binding; ATP-dependent activity, acting on DNA; cadherin binding; DNA helicase activity; helicase activity; hydrolase activity; nucleotide binding; protein binding; TBP-class protein binding; TFIID-class transcription factor complex binding; transcription coactivator activity","chaperone complex; cytoplasm; cytoskeleton; cytosol; dynein axonemal particle; extracellular exosome; Ino80 complex; membrane; microtubule organizing center; MLL1 complex; NuA4 histone acetyltransferase complex; nuclear matrix; nucleoplasm; nucleosome; nucleus; R2TP complex; ribonucleoprotein complex; RPAP3/R2TP/prefoldin-like complex; Swr1 complex","Chromatin remodeling / transcription","RuvB like AAA ATPase 1","http://www.ncbi.nlm.nih.gov/gene/?term=8607","8607","56505","65137","476512",null,"706044","Q9Y265","P60122","P60123","A0A8I3P6G1","F1SPF6","F6VIT7","GO:0101031; GO:0005737; GO:0005856; GO:0005829; GO:0120293; GO:0070062; GO:0031011; GO:0016020; GO:0005815; GO:0071339; GO:0035267; GO:0016363; GO:0005654; GO:0000786; GO:0005634; GO:0097255; GO:1990904; GO:1990062; GO:0000812","GO:0043531; GO:0005524; GO:0016887; GO:0051117; GO:0008094; GO:0045296; GO:0003678; GO:0004386; GO:0016787; GO:0000166; GO:0005515; GO:0017025; GO:0001094; GO:0003713","GO:0000492; GO:0007049; GO:0051301; GO:0006974; GO:0006325; GO:0006338; GO:0051276; GO:0032508; GO:0006310; GO:0006281; GO:0016573; GO:0043968; GO:0043967; GO:0090263; GO:0045739; GO:0045893; GO:1905168; GO:1904874; GO:1904507; GO:0050821; GO:0042981; GO:0051726; GO:0033044; GO:0006282; GO:0006275; GO:0060382; GO:0006355; GO:2000779; GO:0045995; GO:0006357; GO:0007283; GO:0000723","PTHR11093:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10474|UniProtKB=Q9Y265"]
["POU5F1 (OCT4)",null,"POU5F1","45","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0696",".OP., .OT., .TRASR.",null,"POU DOMAIN, CLASS 5, TRANSCRIPTION FACTOR 1-RELATED","anatomical structure morphogenesis; blastocyst development; endodermal cell fate specification; negative regulation of miRNA transcription; negative regulation of miRNA-mediated gene silencing; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of asymmetric cell division; regulation of DNA-templated transcription; regulation of gene expression; regulation of transcription by RNA polymerase II; response to wounding; somatic stem cell population maintenance","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; miRNA binding; protein binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; ubiquitin protein ligase binding","cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus","Stem cell marker","POU class 5 homeobox 1","http://www.ncbi.nlm.nih.gov/gene/?term=5460","5460",null,null,"481709",null,null,"Q01860",null,null,"A0A8P0N3Q7","A0A2C9F339","A0A5F8ASP3","GO:0005737; GO:0005829; GO:0005739; GO:0005654; GO:0005634","GO:0003677; GO:0003700; GO:0000981; GO:0001227; GO:0035198; GO:0005515; GO:0003723; GO:0000978; GO:0043565; GO:1990837; GO:0000976; GO:0031625","GO:0009653; GO:0001824; GO:0001714; GO:1902894; GO:0060965; GO:0000122; GO:0045944; GO:0009786; GO:0006355; GO:0010468; GO:0006357; GO:0009611; GO:0035019","PTHR11636:SF86","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9221|UniProtKB=Q01860"]
["PP1 alpha",null,"PPP1CA","38","rb",null,2,2,2,6,2,2.1,"TK # 078",".APO., .cAMP., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .GPCR., .HIPPO., .INS., .OP., .OPA., .OT., .PLAT., .SREME., .ST., .TRASR., .WNT.","Nicotine pharmacodynamics pathway; Dopamine receptor mediated signaling pathway","SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT","beta-catenin destruction complex disassembly; branching morphogenesis of an epithelial tube; carbohydrate metabolic process; cell cycle; cell division; cell-cell adhesion; circadian regulation of gene expression; dephosphorylation; entrainment of circadian clock by photoperiod; glycogen metabolic process; lung development; negative regulation of protein binding; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; protein dephosphorylation; regulation of canonical Wnt signaling pathway; regulation of circadian rhythm; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process; regulation of translational initiation by eIF2 alpha dephosphorylation; response to lead ion","cadherin binding involved in cell-cell adhesion; hydrolase activity; metal ion binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein phosphatase 1 binding; protein serine/threonine phosphatase activity; protein-containing complex binding; ribonucleoprotein complex binding","adherens junction; chromosome, telomeric region; cytoplasm; cytosol; dendritic spine; extracellular exosome; glutamatergic synapse; glycogen granule; neuron projection; neuronal cell body; nucleolus; nucleoplasm; nucleus; perikaryon; plasma membrane; postsynapse; presynapse; protein phosphatase type 1 complex; PTW/PP1 phosphatase complex","Phosphatases","protein phosphatase 1 catalytic subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5499","5499","19045","24668",null,null,null,"P62136","P62137","P62138",null,"A0A286ZL42","F7CR20","GO:0005912; GO:0000781; GO:0005737; GO:0005829; GO:0043197; GO:0070062; GO:0098978; GO:0042587; GO:0043005; GO:0043025; GO:0005730; GO:0005654; GO:0005634; GO:0043204; GO:0005886; GO:0098794; GO:0098793; GO:0000164; GO:0072357","GO:0098641; GO:0016787; GO:0046872; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0008157; GO:0004722; GO:0044877; GO:0043021","GO:1904886; GO:0048754; GO:0005975; GO:0007049; GO:0051301; GO:0098609; GO:0032922; GO:0016311; GO:0043153; GO:0005977; GO:0030324; GO:0032091; GO:0070262; GO:0035970; GO:2001241; GO:0006470; GO:0060828; GO:0042752; GO:0005979; GO:0005981; GO:0036496; GO:0010288","PTHR11668:SF377","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9281|UniProtKB=P62136","P06587; P05912"]
["PP1 alpha - phospho","Thr320","PPP1CA","38","rb",null,2,2,1,1.1000000000000001,1,1,"TK # 107",".APO., .cAMP., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .GPCR., .HIPPO., .INS., .OP., .OPA., .OT., .PLAT., .SREME., .ST., .TRASR., .WNT.","Nicotine pharmacodynamics pathway; Dopamine receptor mediated signaling pathway","SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT","beta-catenin destruction complex disassembly; branching morphogenesis of an epithelial tube; carbohydrate metabolic process; cell cycle; cell division; cell-cell adhesion; circadian regulation of gene expression; dephosphorylation; entrainment of circadian clock by photoperiod; glycogen metabolic process; lung development; negative regulation of protein binding; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; protein dephosphorylation; regulation of canonical Wnt signaling pathway; regulation of circadian rhythm; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process; regulation of translational initiation by eIF2 alpha dephosphorylation; response to lead ion","cadherin binding involved in cell-cell adhesion; hydrolase activity; metal ion binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein phosphatase 1 binding; protein serine/threonine phosphatase activity; protein-containing complex binding; ribonucleoprotein complex binding","adherens junction; chromosome, telomeric region; cytoplasm; cytosol; dendritic spine; extracellular exosome; glutamatergic synapse; glycogen granule; neuron projection; neuronal cell body; nucleolus; nucleoplasm; nucleus; perikaryon; plasma membrane; postsynapse; presynapse; protein phosphatase type 1 complex; PTW/PP1 phosphatase complex","Phosphatases","protein phosphatase 1 catalytic subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5499","5499","19045","24668",null,null,null,"P62136","P62137","P62138",null,"A0A286ZL42","F7CR20","GO:0005912; GO:0000781; GO:0005737; GO:0005829; GO:0043197; GO:0070062; GO:0098978; GO:0042587; GO:0043005; GO:0043025; GO:0005730; GO:0005654; GO:0005634; GO:0043204; GO:0005886; GO:0098794; GO:0098793; GO:0000164; GO:0072357","GO:0098641; GO:0016787; GO:0046872; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0008157; GO:0004722; GO:0044877; GO:0043021","GO:1904886; GO:0048754; GO:0005975; GO:0007049; GO:0051301; GO:0098609; GO:0032922; GO:0016311; GO:0043153; GO:0005977; GO:0030324; GO:0032091; GO:0070262; GO:0035970; GO:2001241; GO:0006470; GO:0060828; GO:0042752; GO:0005979; GO:0005981; GO:0036496; GO:0010288","PTHR11668:SF377","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9281|UniProtKB=P62136","P06587; P05912"]
["PP1 gamma",null,"PPP1CC","37","rb",null,2,2,6,6,2,2,"# 1021",".cAMP., .CCP., .CCY., .CP., .CSP., .DEV., .GPCR., .HIPPO., .INS., .MAPK., .OP., .OPA., .OT., .PLAT., .RTK., .SREME., .ST., .TRASR.","Nicotine pharmacodynamics pathway; Dopamine receptor mediated signaling pathway","SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT","carbohydrate metabolic process; cell cycle; cell division; circadian regulation of gene expression; entrainment of circadian clock by photoperiod; glycogen metabolic process; MAPK cascade; neuron differentiation; positive regulation of glial cell proliferation; protein dephosphorylation; regulation of circadian rhythm; regulation of nucleocytoplasmic transport; rhythmic process","hydrolase activity; lamin binding; metal ion binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase binding; protein N-terminus binding; protein phosphatase 1 binding; protein phosphatase binding; protein serine/threonine phosphatase activity; protein-containing complex binding; RNA binding","chromosome; chromosome, centromeric region; chromosome, telomeric region; cleavage furrow; cytoplasm; cytoskeleton; cytosol; dendritic spine; focal adhesion; glutamatergic synapse; kinetochore; midbody; mitochondrial outer membrane; mitochondrion; nuclear speck; nucleolus; nucleoplasm; nucleus; postsynapse; presynapse; protein-containing complex; PTW/PP1 phosphatase complex","Phosphatases","protein phosphatase 1 catalytic subunit gamma","http://www.ncbi.nlm.nih.gov/gene/?term=5501","5501","19047","24669",null,null,null,"P36873","P63087","P63088","A0A8I3PYY9","A0A287A6R4","A0A1D5RB68","GO:0005694; GO:0000775; GO:0000781; GO:0032154; GO:0005737; GO:0005856; GO:0005829; GO:0043197; GO:0005925; GO:0098978; GO:0000776; GO:0030496; GO:0005741; GO:0005739; GO:0016607; GO:0005730; GO:0005654; GO:0005634; GO:0098794; GO:0098793; GO:0032991; GO:0072357","GO:0016787; GO:0005521; GO:0046872; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0008022; GO:0019904; GO:0019901; GO:0047485; GO:0008157; GO:0019903; GO:0004722; GO:0044877; GO:0003723","GO:0005975; GO:0007049; GO:0051301; GO:0032922; GO:0043153; GO:0005977; GO:0000165; GO:0030182; GO:0060252; GO:0006470; GO:0042752; GO:0046822; GO:0048511","PTHR11668:SF204","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9283|UniProtKB=P36873","P06587; P05912"]
["PP2A C / PP4 - phospho","Tyr307","PPP2CA","36","rb",null,2,2,5,6,2,2,"# 2170",".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .EGFR., .FGFR., .HIPPO., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .SREME., .ST., .STAT., .TGFB., .TRASR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; FGF signaling pathway; EGF receptor signaling pathway; p53 pathway feedback loops 2; Wnt signaling pathway","SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM","apoptotic process; ceramide metabolic process; meiotic cell cycle; mesoderm development; mitotic cell cycle; negative regulation of cell growth; negative regulation of epithelial to mesenchymal transition; negative regulation of protein kinase B signaling; negative regulation of tyrosine phosphorylation of STAT protein; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of microtubule binding; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein serine/threonine kinase activity; protein dephosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of DNA replication; regulation of DNA-templated transcription; regulation of G1/S transition of mitotic cell cycle; regulation of growth; regulation of microtubule binding; regulation of protein phosphorylation; regulation of Wnt signaling pathway; response to lead ion; response to organic substance; RNA splicing; second-messenger-mediated signaling","GABA receptor binding; hydrolase activity; metal ion binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein C-terminus binding; protein heterodimerization activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; tau protein binding","chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; extracellular exosome; membrane; membrane raft; microtubule cytoskeleton; mitochondrion; nucleus; plasma membrane; protein phosphatase type 2A complex; spindle pole; synapse","Phosphatases","protein phosphatase 2 catalytic subunit alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5515","5515","19052","24672",null,"397656",null,"P67775","P63330","P63331",null,"P67776","A0A1D5Q6V6","GO:0005694; GO:0000775; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0016020; GO:0045121; GO:0015630; GO:0005739; GO:0005634; GO:0005886; GO:0000159; GO:0000922; GO:0045202","GO:0050811; GO:0016787; GO:0046872; GO:0017018; GO:0004721; GO:0005515; GO:0008022; GO:0046982; GO:0004722; GO:0004725; GO:0048156","GO:0006915; GO:0006672; GO:0051321; GO:0007498; GO:0000278; GO:0030308; GO:0010719; GO:0051898; GO:0042532; GO:0070262; GO:0035970; GO:1904528; GO:1900227; GO:0071902; GO:0006470; GO:0030155; GO:0045595; GO:0006275; GO:0006355; GO:2000045; GO:0040008; GO:1904526; GO:0001932; GO:0030111; GO:0010288; GO:0010033; GO:0008380; GO:0019932","PTHR45619:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9299|UniProtKB=P67775","P00059; P04397; P00021; P00018; P04398; P00057"]
["PP2A C alpha/beta",null,"PPP2CA, PPP2CB","38, 36","rb",null,1,1,1,1,1,1,"# 2154",".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .EGFR., .FGFR., .HIPPO., .IMUF., .INFM., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .RAS., .RTK., .SREME., .ST., .STAT., .TGFB., .TNF., .TRASR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; FGF signaling pathway; EGF receptor signaling pathway; p53 pathway feedback loops 2; Wnt signaling pathway","SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM; SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM","apoptotic process; ceramide metabolic process; meiotic cell cycle; mesoderm development; mitotic cell cycle; negative regulation of cell growth; negative regulation of epithelial to mesenchymal transition; negative regulation of protein kinase B signaling; negative regulation of tyrosine phosphorylation of STAT protein; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of microtubule binding; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein serine/threonine kinase activity; protein dephosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of DNA replication; regulation of DNA-templated transcription; regulation of G1/S transition of mitotic cell cycle; regulation of growth; regulation of microtubule binding; regulation of protein phosphorylation; regulation of Wnt signaling pathway; response to lead ion; response to organic substance; RNA splicing; second-messenger-mediated signaling; apoptotic mitochondrial changes; negative regulation of gene expression; negative regulation of NF-kappaB transcription factor activity; negative regulation of Ras protein signal transduction; negative regulation of tumor necrosis factor-mediated signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of gene expression; response to antibiotic; response to endoplasmic reticulum stress; response to hydrogen peroxide","GABA receptor binding; hydrolase activity; metal ion binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein C-terminus binding; protein heterodimerization activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; tau protein binding","chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; extracellular exosome; membrane; membrane raft; microtubule cytoskeleton; mitochondrion; nucleus; plasma membrane; protein phosphatase type 2A complex; spindle pole; synapse","Phosphatases","protein phosphatase 2 catalytic subunit alpha; protein phosphatase 2 catalytic subunit beta","http://www.ncbi.nlm.nih.gov/gene/?term=5515, http://www.ncbi.nlm.nih.gov/gene/?term=5516","5515, 5516","19052, 19053","24672, 24673","","397656, NA","NA, 695118","P67775, P62714","P63330, P62715","P63331, P62716","A0A8I3S1W4","P67776, A0A5G2QB05","A0A1D5Q6V6, F7HSM1","GO:0005694; GO:0000775; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0016020; GO:0045121; GO:0015630; GO:0005739; GO:0005634; GO:0005886; GO:0000159; GO:0000922; GO:0045202","GO:0050811; GO:0016787; GO:0046872; GO:0017018; GO:0004721; GO:0005515; GO:0008022; GO:0046982; GO:0004722; GO:0004725; GO:0048156","GO:0006915; GO:0006672; GO:0051321; GO:0007498; GO:0000278; GO:0030308; GO:0010719; GO:0051898; GO:0042532; GO:0070262; GO:0035970; GO:1904528; GO:1900227; GO:0071902; GO:0006470; GO:0030155; GO:0045595; GO:0006275; GO:0006355; GO:2000045; GO:0040008; GO:1904526; GO:0001932; GO:0030111; GO:0010288; GO:0010033; GO:0008380; GO:0019932; GO:0008637; GO:0010629; GO:0032088; GO:0046580; GO:0010804; GO:0043161; GO:0010468; GO:0046677; GO:0034976; GO:0042542","PTHR45619:SF42; PTHR45619:SF44","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9299|UniProtKB=P67775; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9300|UniProtKB=P62714","P00059; P04397; P00021; P00018; P04398; P00057"]
["PP2A C alpha/beta - phospho","Tyr307","PPP2CA, PPP2CB","35","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1712",".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .EGFR., .FGFR., .HIPPO., .IMUF., .INFM., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .RAS., .RTK., .SREME., .ST., .STAT., .TGFB., .TNF., .TRASR., .WNT.","p53 pathway; p53 pathway by glucose deprivation; FGF signaling pathway; EGF receptor signaling pathway; p53 pathway feedback loops 2; Wnt signaling pathway","SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM; SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM","apoptotic process; ceramide metabolic process; meiotic cell cycle; mesoderm development; mitotic cell cycle; negative regulation of cell growth; negative regulation of epithelial to mesenchymal transition; negative regulation of protein kinase B signaling; negative regulation of tyrosine phosphorylation of STAT protein; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of microtubule binding; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein serine/threonine kinase activity; protein dephosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of DNA replication; regulation of DNA-templated transcription; regulation of G1/S transition of mitotic cell cycle; regulation of growth; regulation of microtubule binding; regulation of protein phosphorylation; regulation of Wnt signaling pathway; response to lead ion; response to organic substance; RNA splicing; second-messenger-mediated signaling; apoptotic mitochondrial changes; negative regulation of gene expression; negative regulation of NF-kappaB transcription factor activity; negative regulation of Ras protein signal transduction; negative regulation of tumor necrosis factor-mediated signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of gene expression; response to antibiotic; response to endoplasmic reticulum stress; response to hydrogen peroxide","GABA receptor binding; hydrolase activity; metal ion binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein C-terminus binding; protein heterodimerization activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; tau protein binding","chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; extracellular exosome; membrane; membrane raft; microtubule cytoskeleton; mitochondrion; nucleus; plasma membrane; protein phosphatase type 2A complex; spindle pole; synapse","Phosphatases","protein phosphatase 2 catalytic subunit alpha; protein phosphatase 2 catalytic subunit beta","http://www.ncbi.nlm.nih.gov/gene/?term=5515, http://www.ncbi.nlm.nih.gov/gene/?term=5516","5515, 5516","19052, 19053","24672, 24673","","397656, NA","NA, 695118","P67775, P62714","P63330, P62715","P63331, P62716","A0A8I3S1W4","P67776, A0A5G2QB05","A0A1D5Q6V6, F7HSM1","GO:0005694; GO:0000775; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0016020; GO:0045121; GO:0015630; GO:0005739; GO:0005634; GO:0005886; GO:0000159; GO:0000922; GO:0045202","GO:0050811; GO:0016787; GO:0046872; GO:0017018; GO:0004721; GO:0005515; GO:0008022; GO:0046982; GO:0004722; GO:0004725; GO:0048156","GO:0006915; GO:0006672; GO:0051321; GO:0007498; GO:0000278; GO:0030308; GO:0010719; GO:0051898; GO:0042532; GO:0070262; GO:0035970; GO:1904528; GO:1900227; GO:0071902; GO:0006470; GO:0030155; GO:0045595; GO:0006275; GO:0006355; GO:2000045; GO:0040008; GO:1904526; GO:0001932; GO:0030111; GO:0010288; GO:0010033; GO:0008380; GO:0019932; GO:0008637; GO:0010629; GO:0032088; GO:0046580; GO:0010804; GO:0043161; GO:0010468; GO:0046677; GO:0034976; GO:0042542","PTHR45619:SF42; PTHR45619:SF44","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9299|UniProtKB=P67775; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9300|UniProtKB=P62714","P00059; P04397; P00021; P00018; P04398; P00057"]
["PP5",null,"PPP5C","58","rb",null,2.1,2,8,8,1.1000000000000001,8.1,"# 1471",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .IMUF., .MAPK., .NFKB., .OP., .OPA., .OT., .RTK., .ST., .TRASR.",null,"SERINE/THREONINE-PROTEIN PHOSPHATASE 5","cellular response to DNA damage stimulus; DNA repair; DNA-templated transcription; double-strand break repair; MAPK cascade; mitotic cell cycle; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein dephosphorylation; response to arachidonic acid; response to lead ion; response to morphine","ADP binding; ATP binding; Hsp90 protein binding; hydrolase activity; identical protein binding; lipid binding; metal ion binding; molecular adaptor activity; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; RNA binding; tau protein binding","chaperone complex; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex","Phosphatases","protein phosphatase 5 catalytic subunit","http://www.ncbi.nlm.nih.gov/gene/?term=5536","5536","19060","65179",null,null,"716214","P53041","Q60676","P53042","A0A8I3MKV9","A0A5G2R740","A0A5F7ZXV1","GO:0101031; GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005654; GO:0005634; GO:0005886; GO:0032991","GO:0043531; GO:0005524; GO:0051879; GO:0016787; GO:0042802; GO:0008289; GO:0046872; GO:0060090; GO:0017018; GO:0016791; GO:0004721; GO:0005515; GO:0004722; GO:0003723; GO:0048156","GO:0006974; GO:0006281; GO:0006351; GO:0006302; GO:0000165; GO:0000278; GO:0070262; GO:0035970; GO:0043123; GO:0006470; GO:1904550; GO:0010288; GO:0043278","PTHR45668:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9322|UniProtKB=P53041"]
["PPAR alpha",null,"PPARA","55","rb",null,6,2,2.1,7,8,8,"# 1679",".cAMP., .CCP., .CP., .CSP., .DEV., .DRR., .GPCR., .HIF., .IMFR., .IMUR., .INS., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TGFB., .TRASR., .VIR.","Gonadotropin releasing hormone receptor pathway","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA","behavioral response to nicotine; cell communication; cell differentiation; cellular response to starvation; cellular response to stimulus; circadian regulation of gene expression; enamel mineralization; epidermis development; fatty acid metabolic process; gluconeogenesis; heart development; hormone-mediated signaling pathway; intracellular receptor signaling pathway; lipid localization; lipoprotein metabolic process; negative regulation of appetite; negative regulation of blood pressure; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of cholesterol storage; negative regulation of cytokine production involved in inflammatory response; negative regulation of glycolytic process; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of leukocyte cell-cell adhesion; negative regulation of macrophage derived foam cell differentiation; negative regulation of miRNA transcription; negative regulation of neuron death; negative regulation of protein binding; negative regulation of protein kinase B signaling; negative regulation of reactive oxygen species biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of signaling receptor activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of ATP biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of fatty acid beta-oxidation; positive regulation of fatty acid metabolic process; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of lipid biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of viral genome replication; regulation of cellular ketone metabolic process; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of fatty acid metabolic process; regulation of fatty acid transport; regulation of gene expression; regulation of lipid metabolic process; regulation of lipid storage; regulation of transcription by RNA polymerase II; response to ethanol; response to hypoxia; response to insulin; response to lipid; response to organic cyclic compound; rhythmic process; steroid hormone mediated signaling pathway; wound healing","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; lipid binding; MDM2/MDM4 family protein binding; metal ion binding; NFAT protein binding; nuclear receptor activity; nuclear steroid receptor activity; phosphatase binding; protein binding; protein domain specific binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling receptor activity; transcription coactivator binding; ubiquitin conjugating enzyme binding; zinc ion binding","chromatin; nucleoplasm; nucleus","Nuclear receptor","peroxisome proliferator activated receptor alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5465","5465","19013","25747",null,null,null,"Q07869","P23204","P37230","A0A8I3N5V2","F1SM76","G7N476","GO:0000785; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0008289; GO:0097371; GO:0046872; GO:0051525; GO:0004879; GO:0003707; GO:0019902; GO:0005515; GO:0019904; GO:0044877; GO:0000978; GO:0061629; GO:0043565; GO:0038023; GO:0001223; GO:0031624; GO:0008270","GO:0035095; GO:0007154; GO:0030154; GO:0009267; GO:0051716; GO:0032922; GO:0070166; GO:0008544; GO:0006631; GO:0006094; GO:0007507; GO:0009755; GO:0030522; GO:0010876; GO:0042157; GO:0032099; GO:0045776; GO:0061052; GO:0010887; GO:1900016; GO:0045820; GO:1903944; GO:0050728; GO:1903038; GO:0010745; GO:1902894; GO:1901215; GO:0032091; GO:0051898; GO:1903427; GO:0010891; GO:2000272; GO:0000122; GO:0030512; GO:2001171; GO:0045893; GO:0032000; GO:0045923; GO:0046321; GO:0045722; GO:0046889; GO:0045944; GO:0045070; GO:0010565; GO:0042752; GO:0006355; GO:0019217; GO:2000191; GO:0010468; GO:0019216; GO:0010883; GO:0006357; GO:0045471; GO:0001666; GO:0032868; GO:0033993; GO:0014070; GO:0048511; GO:0043401; GO:0042060","PTHR24082:SF197","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9232|UniProtKB=Q07869","P06664"]
["PPAR alpha",null,"PPARA","52","rb",null,1,6,6,6,6,6,"# 1794",".cAMP., .CCP., .CP., .CSP., .DEV., .DRR., .GPCR., .HIF., .IMFR., .IMUR., .INS., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TGFB., .TRASR., .VIR.","Gonadotropin releasing hormone receptor pathway","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA","behavioral response to nicotine; cell communication; cell differentiation; cellular response to starvation; cellular response to stimulus; circadian regulation of gene expression; enamel mineralization; epidermis development; fatty acid metabolic process; gluconeogenesis; heart development; hormone-mediated signaling pathway; intracellular receptor signaling pathway; lipid localization; lipoprotein metabolic process; negative regulation of appetite; negative regulation of blood pressure; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of cholesterol storage; negative regulation of cytokine production involved in inflammatory response; negative regulation of glycolytic process; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of leukocyte cell-cell adhesion; negative regulation of macrophage derived foam cell differentiation; negative regulation of miRNA transcription; negative regulation of neuron death; negative regulation of protein binding; negative regulation of protein kinase B signaling; negative regulation of reactive oxygen species biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of signaling receptor activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of ATP biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of fatty acid beta-oxidation; positive regulation of fatty acid metabolic process; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of lipid biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of viral genome replication; regulation of cellular ketone metabolic process; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of fatty acid metabolic process; regulation of fatty acid transport; regulation of gene expression; regulation of lipid metabolic process; regulation of lipid storage; regulation of transcription by RNA polymerase II; response to ethanol; response to hypoxia; response to insulin; response to lipid; response to organic cyclic compound; rhythmic process; steroid hormone mediated signaling pathway; wound healing","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; lipid binding; MDM2/MDM4 family protein binding; metal ion binding; NFAT protein binding; nuclear receptor activity; nuclear steroid receptor activity; phosphatase binding; protein binding; protein domain specific binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling receptor activity; transcription coactivator binding; ubiquitin conjugating enzyme binding; zinc ion binding","chromatin; nucleoplasm; nucleus","Nuclear receptor","peroxisome proliferator activated receptor alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5465","5465","19013","25747",null,null,null,"Q07869","P23204","P37230","A0A8I3N5V2","F1SM76","G7N476","GO:0000785; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0008289; GO:0097371; GO:0046872; GO:0051525; GO:0004879; GO:0003707; GO:0019902; GO:0005515; GO:0019904; GO:0044877; GO:0000978; GO:0061629; GO:0043565; GO:0038023; GO:0001223; GO:0031624; GO:0008270","GO:0035095; GO:0007154; GO:0030154; GO:0009267; GO:0051716; GO:0032922; GO:0070166; GO:0008544; GO:0006631; GO:0006094; GO:0007507; GO:0009755; GO:0030522; GO:0010876; GO:0042157; GO:0032099; GO:0045776; GO:0061052; GO:0010887; GO:1900016; GO:0045820; GO:1903944; GO:0050728; GO:1903038; GO:0010745; GO:1902894; GO:1901215; GO:0032091; GO:0051898; GO:1903427; GO:0010891; GO:2000272; GO:0000122; GO:0030512; GO:2001171; GO:0045893; GO:0032000; GO:0045923; GO:0046321; GO:0045722; GO:0046889; GO:0045944; GO:0045070; GO:0010565; GO:0042752; GO:0006355; GO:0019217; GO:2000191; GO:0010468; GO:0019216; GO:0010883; GO:0006357; GO:0045471; GO:0001666; GO:0032868; GO:0033993; GO:0014070; GO:0048511; GO:0043401; GO:0042060","PTHR24082:SF197","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9232|UniProtKB=Q07869","P06664"]
["PPAR alpha - phospho","Ser12","PPARA","52","rb",null,2,6,6,6,6,6,"# 1815",".cAMP., .CCP., .CP., .CSP., .DEV., .DRR., .GPCR., .HIF., .IMFR., .IMUR., .INS., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TGFB., .TRASR., .VIR.","Gonadotropin releasing hormone receptor pathway","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA","behavioral response to nicotine; cell communication; cell differentiation; cellular response to starvation; cellular response to stimulus; circadian regulation of gene expression; enamel mineralization; epidermis development; fatty acid metabolic process; gluconeogenesis; heart development; hormone-mediated signaling pathway; intracellular receptor signaling pathway; lipid localization; lipoprotein metabolic process; negative regulation of appetite; negative regulation of blood pressure; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of cholesterol storage; negative regulation of cytokine production involved in inflammatory response; negative regulation of glycolytic process; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of leukocyte cell-cell adhesion; negative regulation of macrophage derived foam cell differentiation; negative regulation of miRNA transcription; negative regulation of neuron death; negative regulation of protein binding; negative regulation of protein kinase B signaling; negative regulation of reactive oxygen species biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of signaling receptor activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of ATP biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of fatty acid beta-oxidation; positive regulation of fatty acid metabolic process; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of lipid biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of viral genome replication; regulation of cellular ketone metabolic process; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of fatty acid metabolic process; regulation of fatty acid transport; regulation of gene expression; regulation of lipid metabolic process; regulation of lipid storage; regulation of transcription by RNA polymerase II; response to ethanol; response to hypoxia; response to insulin; response to lipid; response to organic cyclic compound; rhythmic process; steroid hormone mediated signaling pathway; wound healing","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; lipid binding; MDM2/MDM4 family protein binding; metal ion binding; NFAT protein binding; nuclear receptor activity; nuclear steroid receptor activity; phosphatase binding; protein binding; protein domain specific binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling receptor activity; transcription coactivator binding; ubiquitin conjugating enzyme binding; zinc ion binding","chromatin; nucleoplasm; nucleus","Nuclear receptor","peroxisome proliferator activated receptor alpha","http://www.ncbi.nlm.nih.gov/gene/?term=5465","5465","19013","25747",null,null,null,"Q07869","P23204","P37230","A0A8I3N5V2","F1SM76","G7N476","GO:0000785; GO:0005654; GO:0005634","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0008289; GO:0097371; GO:0046872; GO:0051525; GO:0004879; GO:0003707; GO:0019902; GO:0005515; GO:0019904; GO:0044877; GO:0000978; GO:0061629; GO:0043565; GO:0038023; GO:0001223; GO:0031624; GO:0008270","GO:0035095; GO:0007154; GO:0030154; GO:0009267; GO:0051716; GO:0032922; GO:0070166; GO:0008544; GO:0006631; GO:0006094; GO:0007507; GO:0009755; GO:0030522; GO:0010876; GO:0042157; GO:0032099; GO:0045776; GO:0061052; GO:0010887; GO:1900016; GO:0045820; GO:1903944; GO:0050728; GO:1903038; GO:0010745; GO:1902894; GO:1901215; GO:0032091; GO:0051898; GO:1903427; GO:0010891; GO:2000272; GO:0000122; GO:0030512; GO:2001171; GO:0045893; GO:0032000; GO:0045923; GO:0046321; GO:0045722; GO:0046889; GO:0045944; GO:0045070; GO:0010565; GO:0042752; GO:0006355; GO:0019217; GO:2000191; GO:0010468; GO:0019216; GO:0010883; GO:0006357; GO:0045471; GO:0001666; GO:0032868; GO:0033993; GO:0014070; GO:0048511; GO:0043401; GO:0042060","PTHR24082:SF197","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9232|UniProtKB=Q07869","P06664"]
["PPAR gamma",null,"PPARG","52","rb",null,2,2,2,2,6,6,"# 1297",".AMPK., .ANG., .APO., .BMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .DI., .GPCR., .GPROT., .HIF., .HUNT., .IIR., .IMFR., .IMUF., .IMUR., .INFG., .INFM., .INS., .MAPK., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TGFB., .TRASR., .TYR.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","activation of cysteine-type endopeptidase activity involved in apoptotic process; BMP signaling pathway; cell communication; cell differentiation; cell fate commitment; cell maturation; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to low-density lipoprotein particle stimulus; cellular response to stimulus; epithelial cell differentiation; fatty acid metabolic process; G protein-coupled receptor signaling pathway; glucose homeostasis; hormone-mediated signaling pathway; innate immune response; lipid homeostasis; lipid metabolic process; lipoprotein transport; long-chain fatty acid transport; macrophage derived foam cell differentiation; monocyte differentiation; mRNA transcription by RNA polymerase II; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of BMP signaling pathway; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of cellular response to transforming growth factor beta stimulus; negative regulation of cholesterol storage; negative regulation of connective tissue replacement involved in inflammatory response wound healing; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; negative regulation of MAP kinase activity; negative regulation of miRNA transcription; negative regulation of miRNA-mediated gene silencing; negative regulation of mitochondrial fission; negative regulation of osteoblast differentiation; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of receptor signaling pathway via STAT; negative regulation of sequestering of triglyceride; negative regulation of signaling receptor activity; negative regulation of SMAD protein signal transduction; negative regulation of smooth muscle cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of type II interferon-mediated signaling pathway; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular endothelial cell proliferation; peroxisome proliferator activated receptor signaling pathway; placenta development; positive regulation of adiponectin secretion; positive regulation of adipose tissue development; positive regulation of cholesterol efflux; positive regulation of DNA binding; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of fatty acid metabolic process; positive regulation of gene expression; positive regulation of low-density lipoprotein receptor activity; positive regulation of miRNA transcription; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of vascular associated smooth muscle cell apoptotic process; regulation of blood pressure; regulation of cellular response to insulin stimulus; regulation of cholesterol transporter activity; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; response to lipid; response to nutrient; retinoic acid receptor signaling pathway; rhythmic process; signal transduction; white fat cell differentiation","alpha-actinin binding; arachidonic acid binding; chromatin binding; DNA binding; DNA binding domain binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; E-box binding; enzyme binding; identical protein binding; LBD domain binding; metal ion binding; nuclear receptor activity; nuclear retinoid X receptor binding; nucleic acid binding; peptide binding; prostaglandin receptor activity; protein binding; protein C-terminus binding; protein self-association; RNA polymerase II cis-regulatory region sequence-specific DNA binding; R-SMAD binding; sequence-specific DNA binding; STAT family protein binding; transcription cis-regulatory region binding; transcription coregulator binding; zinc ion binding","chromatin; cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm; nucleus; receptor complex; RNA polymerase II transcription regulator complex","Transcription regulation","peroxisome proliferator activated receptor gamma","http://www.ncbi.nlm.nih.gov/gene/?term=5468","5468",null,"25664",null,"397671","574190","P37231","A0A0N4SV67","O88275","A0A8I3Q661","O62807","O18924","GO:0000785; GO:0005737; GO:0005829; GO:0043231; GO:0005654; GO:0005634; GO:0043235; GO:0090575","GO:0051393; GO:0050544; GO:0003682; GO:0003677; GO:0050692; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0003690; GO:0070888; GO:0019899; GO:0042802; GO:0050693; GO:0046872; GO:0004879; GO:0046965; GO:0003676; GO:0042277; GO:0004955; GO:0005515; GO:0008022; GO:0043621; GO:0000978; GO:0070412; GO:0043565; GO:0097677; GO:0000976; GO:0001221; GO:0008270","GO:0006919; GO:0030509; GO:0007154; GO:0030154; GO:0045165; GO:0048469; GO:0071456; GO:0032869; GO:0071404; GO:0051716; GO:0030855; GO:0006631; GO:0007186; GO:0042593; GO:0009755; GO:0045087; GO:0055088; GO:0006629; GO:0042953; GO:0015909; GO:0010742; GO:0030224; GO:0042789; GO:0016525; GO:0043537; GO:0030514; GO:1903243; GO:1903845; GO:0010887; GO:1904597; GO:0045892; GO:0010629; GO:0050728; GO:0010888; GO:0010745; GO:0043407; GO:1902894; GO:0060965; GO:0090258; GO:0045668; GO:0060394; GO:1904893; GO:0010891; GO:2000272; GO:0060392; GO:0048662; GO:0000122; GO:0030512; GO:0060336; GO:1904706; GO:1905563; GO:0035357; GO:0001890; GO:0070165; GO:1904179; GO:0010875; GO:0043388; GO:0051091; GO:0045893; GO:0045600; GO:0045923; GO:0010628; GO:1905599; GO:1902895; GO:0010862; GO:0060391; GO:0045944; GO:1905461; GO:0008217; GO:1900076; GO:0060694; GO:0042752; GO:0006355; GO:0019216; GO:0006357; GO:0033993; GO:0007584; GO:0048384; GO:0048511; GO:0007165; GO:0050872","PTHR24082:SF488","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9236|UniProtKB=P37231","P06959; P06664"]
["PPAR gamma - phospho","Ser112","PPARG","52","rb",null,2,2,2,2,6,6,"# 1296",".AMPK., .ANG., .APO., .BMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .DI., .GPCR., .GPROT., .HIF., .HUNT., .IIR., .IMFR., .IMUF., .IMUR., .INFG., .INFM., .INS., .MAPK., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TGFB., .TRASR., .TYR.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","activation of cysteine-type endopeptidase activity involved in apoptotic process; BMP signaling pathway; cell communication; cell differentiation; cell fate commitment; cell maturation; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to low-density lipoprotein particle stimulus; cellular response to stimulus; epithelial cell differentiation; fatty acid metabolic process; G protein-coupled receptor signaling pathway; glucose homeostasis; hormone-mediated signaling pathway; innate immune response; lipid homeostasis; lipid metabolic process; lipoprotein transport; long-chain fatty acid transport; macrophage derived foam cell differentiation; monocyte differentiation; mRNA transcription by RNA polymerase II; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of BMP signaling pathway; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of cellular response to transforming growth factor beta stimulus; negative regulation of cholesterol storage; negative regulation of connective tissue replacement involved in inflammatory response wound healing; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; negative regulation of MAP kinase activity; negative regulation of miRNA transcription; negative regulation of miRNA-mediated gene silencing; negative regulation of mitochondrial fission; negative regulation of osteoblast differentiation; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of receptor signaling pathway via STAT; negative regulation of sequestering of triglyceride; negative regulation of signaling receptor activity; negative regulation of SMAD protein signal transduction; negative regulation of smooth muscle cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of type II interferon-mediated signaling pathway; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular endothelial cell proliferation; peroxisome proliferator activated receptor signaling pathway; placenta development; positive regulation of adiponectin secretion; positive regulation of adipose tissue development; positive regulation of cholesterol efflux; positive regulation of DNA binding; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of fatty acid metabolic process; positive regulation of gene expression; positive regulation of low-density lipoprotein receptor activity; positive regulation of miRNA transcription; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of vascular associated smooth muscle cell apoptotic process; regulation of blood pressure; regulation of cellular response to insulin stimulus; regulation of cholesterol transporter activity; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; response to lipid; response to nutrient; retinoic acid receptor signaling pathway; rhythmic process; signal transduction; white fat cell differentiation","alpha-actinin binding; arachidonic acid binding; chromatin binding; DNA binding; DNA binding domain binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; E-box binding; enzyme binding; identical protein binding; LBD domain binding; metal ion binding; nuclear receptor activity; nuclear retinoid X receptor binding; nucleic acid binding; peptide binding; prostaglandin receptor activity; protein binding; protein C-terminus binding; protein self-association; RNA polymerase II cis-regulatory region sequence-specific DNA binding; R-SMAD binding; sequence-specific DNA binding; STAT family protein binding; transcription cis-regulatory region binding; transcription coregulator binding; zinc ion binding","chromatin; cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm; nucleus; receptor complex; RNA polymerase II transcription regulator complex","Transcription regulation","peroxisome proliferator activated receptor gamma","http://www.ncbi.nlm.nih.gov/gene/?term=5468","5468",null,"25664",null,"397671","574190","P37231","A0A0N4SV67","O88275","A0A8I3Q661","O62807","O18924","GO:0000785; GO:0005737; GO:0005829; GO:0043231; GO:0005654; GO:0005634; GO:0043235; GO:0090575","GO:0051393; GO:0050544; GO:0003682; GO:0003677; GO:0050692; GO:0003700; GO:0000981; GO:0140297; GO:0001227; GO:0003690; GO:0070888; GO:0019899; GO:0042802; GO:0050693; GO:0046872; GO:0004879; GO:0046965; GO:0003676; GO:0042277; GO:0004955; GO:0005515; GO:0008022; GO:0043621; GO:0000978; GO:0070412; GO:0043565; GO:0097677; GO:0000976; GO:0001221; GO:0008270","GO:0006919; GO:0030509; GO:0007154; GO:0030154; GO:0045165; GO:0048469; GO:0071456; GO:0032869; GO:0071404; GO:0051716; GO:0030855; GO:0006631; GO:0007186; GO:0042593; GO:0009755; GO:0045087; GO:0055088; GO:0006629; GO:0042953; GO:0015909; GO:0010742; GO:0030224; GO:0042789; GO:0016525; GO:0043537; GO:0030514; GO:1903243; GO:1903845; GO:0010887; GO:1904597; GO:0045892; GO:0010629; GO:0050728; GO:0010888; GO:0010745; GO:0043407; GO:1902894; GO:0060965; GO:0090258; GO:0045668; GO:0060394; GO:1904893; GO:0010891; GO:2000272; GO:0060392; GO:0048662; GO:0000122; GO:0030512; GO:0060336; GO:1904706; GO:1905563; GO:0035357; GO:0001890; GO:0070165; GO:1904179; GO:0010875; GO:0043388; GO:0051091; GO:0045893; GO:0045600; GO:0045923; GO:0010628; GO:1905599; GO:1902895; GO:0010862; GO:0060391; GO:0045944; GO:1905461; GO:0008217; GO:1900076; GO:0060694; GO:0042752; GO:0006355; GO:0019216; GO:0006357; GO:0033993; GO:0007584; GO:0048384; GO:0048511; GO:0007165; GO:0050872","PTHR24082:SF488","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9236|UniProtKB=P37231","P06959; P06664"]
["PRAME",null,"PRAME","58","gt",null,6,7,"n/a","n/a","n/a","n/a","# 0894",".APO., .CCP., .CD., .CP., .CSP., .OP., .OPA., .OT., .ST., .TRASR., .UBI.",null,"MELANOMA ANTIGEN PREFERENTIALLY EXPRESSED IN TUMORS","apoptotic process; cell differentiation; negative regulation of apoptotic process; negative regulation of cell differentiation; negative regulation of DNA-templated transcription; negative regulation of retinoic acid receptor signaling pathway; positive regulation of cell population proliferation; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination","nuclear retinoic acid receptor binding; protein binding; ubiquitin ligase-substrate adaptor activity","chromatin; chromosome; Cul2-RING ubiquitin ligase complex; cytoplasm; Golgi apparatus; membrane; nucleoplasm; nucleus; plasma membrane","Transcription regulation","PRAME nuclear receptor transcriptional regulator","http://www.ncbi.nlm.nih.gov/gene/?term=23532","23532",null,null,null,null,null,"P78395",null,null,"A0A8I3Q5C6",null,"A0A1D5R115","GO:0000785; GO:0005694; GO:0031462; GO:0005737; GO:0005794; GO:0016020; GO:0005654; GO:0005634; GO:0005886","GO:0042974; GO:0005515; GO:1990756","GO:0006915; GO:0030154; GO:0043066; GO:0045596; GO:0045892; GO:0048387; GO:0008284; GO:0043161; GO:0000209; GO:0016567","PTHR14224:SF24","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9336|UniProtKB=P78395"]
["PRAS40",null,"AKT1S1","40","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2081",".AMPK., .APH., .APO., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OPA., .RTK., .SREME., .ST.","CCKR signaling map","PROLINE-RICH AKT1 SUBSTRATE 1","negative regulation of cell size; negative regulation of protein kinase activity; negative regulation of TOR signaling; neurotrophin TRK receptor signaling pathway; regulation of apoptotic process; regulation of neuron apoptotic process","protein binding","cytoplasm; cytosol; nucleoplasm; TORC1 complex",null,"AKT1 substrate 1","http://www.ncbi.nlm.nih.gov/gene/?term=84335","84335","67605","292887","610130",null,null,"Q96B36","Q9D1F4","A0A8I5ZRQ9","A0A8I3PHV6","A0A5G2QRU9",null,"GO:0005737; GO:0005829; GO:0005654; GO:0031931","GO:0005515","GO:0045792; GO:0006469; GO:0032007; GO:0048011; GO:0042981; GO:0043523","PTHR21844:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=28426|UniProtKB=Q96B36","P06959"]
["PRAS40",null,"AKT1S1","40","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2100",".AMPK., .APH., .APO., .CCKR., .CD., .CSP., .MTOR., .OPA., .RTK., .SREME., .ST.","CCKR signaling map","PROLINE-RICH AKT1 SUBSTRATE 1","negative regulation of cell size; negative regulation of protein kinase activity; negative regulation of TOR signaling; neurotrophin TRK receptor signaling pathway; regulation of apoptotic process; regulation of neuron apoptotic process","protein binding","cytoplasm; cytosol; nucleoplasm; TORC1 complex",null,"AKT1 substrate 1","http://www.ncbi.nlm.nih.gov/gene/?term=84335","84335","67605","292887","610130",null,null,"Q96B36","Q9D1F4","A0A8I5ZRQ9","A0A8I3PHV6","A0A5G2QRU9",null,"GO:0005737; GO:0005829; GO:0005654; GO:0031931","GO:0005515","GO:0045792; GO:0006469; GO:0032007; GO:0048011; GO:0042981; GO:0043523","PTHR21844:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=28426|UniProtKB=Q96B36","P06959"]
["PRAS40 - phospho","Ser183","AKT1S1","40","rb",null,2,1.1000000000000001,"n/a","n/a","n/a","n/a","# 2380",".AMPK., .APH., .APO., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OPA., .RTK., .SREME., .ST.","CCKR signaling map","PROLINE-RICH AKT1 SUBSTRATE 1","negative regulation of cell size; negative regulation of protein kinase activity; negative regulation of TOR signaling; neurotrophin TRK receptor signaling pathway; regulation of apoptotic process; regulation of neuron apoptotic process","protein binding","cytoplasm; cytosol; nucleoplasm; TORC1 complex",null,"AKT1 substrate 1","http://www.ncbi.nlm.nih.gov/gene/?term=84335","84335","67605","292887","610130",null,null,"Q96B36","Q9D1F4","A0A8I5ZRQ9","A0A8I3PHV6","A0A5G2QRU9",null,"GO:0005737; GO:0005829; GO:0005654; GO:0031931","GO:0005515","GO:0045792; GO:0006469; GO:0032007; GO:0048011; GO:0042981; GO:0043523","PTHR21844:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=28426|UniProtKB=Q96B36","P06959"]
["PRAS40 - phospho","Thr246","AKT1S1","40","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2487",".AMPK., .APH., .APO., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OPA., .RTK., .SREME., .ST.","CCKR signaling map","PROLINE-RICH AKT1 SUBSTRATE 1","negative regulation of cell size; negative regulation of protein kinase activity; negative regulation of TOR signaling; neurotrophin TRK receptor signaling pathway; regulation of apoptotic process; regulation of neuron apoptotic process","protein binding","cytoplasm; cytosol; nucleoplasm; TORC1 complex",null,"AKT1 substrate 1","http://www.ncbi.nlm.nih.gov/gene/?term=84335","84335","67605","292887","610130",null,null,"Q96B36","Q9D1F4","A0A8I5ZRQ9","A0A8I3PHV6","A0A5G2QRU9",null,"GO:0005737; GO:0005829; GO:0005654; GO:0031931","GO:0005515","GO:0045792; GO:0006469; GO:0032007; GO:0048011; GO:0042981; GO:0043523","PTHR21844:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=28426|UniProtKB=Q96B36","P06959"]
["PRDM14",null,"PRDM14","64","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1701",".CSP., .FGFR., .OP., .OT., .RTK., .TRASR.",null,"PR DOMAIN ZINC FINGER PROTEIN 14","cell fate specification; cell morphogenesis; embryo implantation; epigenetic regulation of gene expression; fertilization; fibroblast growth factor receptor signaling pathway; germ cell development; germ-line stem cell population maintenance; histone H3-R26 methylation; homeostasis of number of cells within a tissue; inactivation of paternal X chromosome; inner cell mass cell fate commitment; methylation; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of flagellated sperm motility; positive regulation of stem cell population maintenance; regulation of DNA methylation; regulation of gene expression; regulation of transcription by RNA polymerase II; stem cell population maintenance","chromatin DNA binding; DNA binding; metal ion binding; methyltransferase activity; protein binding; RNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transferase activity","nucleoplasm; nucleus",null,"PR/SET domain 14","http://www.ncbi.nlm.nih.gov/gene/?term=63978","63978","383491","100365184",null,null,null,"Q9GZV8","E9Q3T6","D3ZI87","A0A8P0SRF5","F1RU08",null,"GO:0005654; GO:0005634","GO:0031490; GO:0003677; GO:0046872; GO:0008168; GO:0005515; GO:0003723; GO:0000977; GO:0016740","GO:0001708; GO:0000902; GO:0007566; GO:0040029; GO:0009566; GO:0008543; GO:0007281; GO:0030718; GO:0034972; GO:0048873; GO:0060817; GO:0001827; GO:0032259; GO:0040037; GO:0000122; GO:1902093; GO:1902459; GO:0044030; GO:0010468; GO:0006357; GO:0019827","PTHR16515:SF19","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=14001|UniProtKB=Q9GZV8"]
["PRK2",null,"PKN2","140","rb",null,2,2,8,8,8,8,"# 1005",".ALZ., .APO., .CCP., .CCY., .CD., .CP., .CSP., .DI., .IMUR., .MIG., .OP., .OPA., .OT., .PDGF., .PI3K., .RTK., .ST., .VIR.","Muscarinic acetylcholine receptor 1 and 3 signaling pathway; PDGF signaling pathway; Alzheimer disease-amyloid secretase pathway","SERINE/THREONINE-PROTEIN KINASE N2","apical junction assembly; apoptotic process; cell adhesion; cell cycle; cell division; cell projection organization; epithelial cell migration; intracellular signal transduction; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cytokinesis; positive regulation of mitotic cell cycle; positive regulation of viral genome replication; protein phosphorylation; regulation of cell motility; signal transduction","ATP binding; cadherin binding; calcium-dependent protein kinase C activity; histone deacetylase binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine kinase activity; protein serine/threonine kinase activity; RNA binding; RNA polymerase binding; small GTPase binding; transferase activity","anchoring junction; apical junction complex; cell projection; centrosome; cleavage furrow; cytoplasm; cytoskeleton; cytosol; intermediate filament cytoskeleton; lamellipodium; membrane; midbody; nuclear body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex","Ca / cAMP / lipid signaling","protein kinase N2","http://www.ncbi.nlm.nih.gov/gene/?term=5586","5586","109333",null,null,null,null,"Q16513","Q8BWW9","A0A0G2K6J2","A0A8I3NX96","A0A286ZLF6","A0A1D5QYM8","GO:0070161; GO:0043296; GO:0042995; GO:0005813; GO:0032154; GO:0005737; GO:0005856; GO:0005829; GO:0045111; GO:0030027; GO:0016020; GO:0030496; GO:0016604; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0032991","GO:0005524; GO:0045296; GO:0004698; GO:0042826; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004697; GO:0106310; GO:0004674; GO:0003723; GO:0070063; GO:0031267; GO:0016740","GO:0043297; GO:0006915; GO:0007155; GO:0007049; GO:0051301; GO:0030030; GO:0010631; GO:0035556; GO:0018105; GO:0016310; GO:0032467; GO:0045931; GO:0045070; GO:0006468; GO:2000145; GO:0007165","PTHR24356:SF322","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9406|UniProtKB=Q16513","P00042; P00047; P00003"]
["PRL-1 (PTP4A1)",null,"PTP4A1","20","gt",null,6,6,"n/a","n/a","n/a","n/a","# 0418",".CCP., .CCY., .CSP., .MIG., .OP., .OPA., .OT., .ST.",null,"PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1","cell cycle; dephosphorylation; positive regulation of cell migration; protein dephosphorylation","hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity","cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; early endosome; endoplasmic reticulum; endosome; membrane; nucleus; plasma membrane; spindle","Cell cycle control","protein tyrosine phosphatase 4A1","http://www.ncbi.nlm.nih.gov/gene/?term=7803","7803","19243","29463",null,null,"716195","Q93096","Q63739","Q78EG7","A0A8I3N0J7","I3LCL5","H9ENR5","GO:0005737; GO:0009898; GO:0005856; GO:0005769; GO:0005783; GO:0005768; GO:0016020; GO:0005634; GO:0005886; GO:0005819","GO:0016787; GO:0016791; GO:0004721; GO:0005515; GO:0004725; GO:0008138","GO:0007049; GO:0016311; GO:0030335; GO:0006470","PTHR23339:SF55","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9634|UniProtKB=Q93096"]
["PRL-3 (PTP4A3)",null,"PTP4A3","22","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0491",".CSP., .DEV., .IMUF., .NFKB., .NOTCH., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .VEGFS.",null,"PROTEIN TYROSINE PHOSPHATASE TYPE IVA 3","cellular response to leukemia inhibitory factor; dephosphorylation; endothelial cell migration; Notch signaling pathway; positive regulation of establishment of protein localization; positive regulation of NIK/NF-kappaB signaling; positive regulation of vascular permeability; protein dephosphorylation; regulation of DNA-templated transcription; regulation of vascular endothelial growth factor signaling pathway","hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; prenylated protein tyrosine phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity","cytoplasm; early endosome; endosome; membrane; nucleus; plasma membrane","Phosphatases","protein tyrosine phosphatase 4A3","http://www.ncbi.nlm.nih.gov/gene/?term=11156","11156","19245","362930",null,null,"693703","O75365","Q9D658","B0K032","A0A8I3NJL3",null,"A0A1D5QJX9","GO:0005737; GO:0005769; GO:0005768; GO:0016020; GO:0005634; GO:0005886","GO:0016787; GO:0016791; GO:0004721; GO:0004727; GO:0005515; GO:0004725; GO:0008138","GO:1990830; GO:0016311; GO:0043542; GO:0007219; GO:1904951; GO:1901224; GO:0043117; GO:0006470; GO:0006355; GO:1900746","PTHR23339:SF119","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9636|UniProtKB=O75365"]
["PRMT1",null,"PRMT1","41","rb",null,2,2,1,1,2,2,"# 1093",".CCP., .CP., .CSP., .FOXO., .IMUR., .JNK., .OP., .OPA., .P38., .SREME., .ST., .VIR.",null,"PROTEIN ARGININE N-METHYLTRANSFERASE 1","cardiac muscle tissue development; cell surface receptor signaling pathway; histone H4-R3 methylation; histone methylation; in utero embryonic development; methylation; negative regulation of JNK cascade; negative regulation of megakaryocyte differentiation; neuron projection development; peptidyl-arginine methylation; positive regulation of cell population proliferation; positive regulation of erythrocyte differentiation; positive regulation of hemoglobin biosynthetic process; positive regulation of p38MAPK cascade; protein homooligomerization; protein methylation; regulation of megakaryocyte differentiation; RNA splicing; viral protein processing","enzyme binding; histone H4R3 methyltransferase activity; histone methyltransferase activity; identical protein binding; methyl-CpG binding; methyltransferase activity; mitogen-activated protein kinase p38 binding; N-methyltransferase activity; protein binding; protein methyltransferase activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; RNA binding; S-adenosyl-L-methionine binding; S-adenosylmethionine-dependent methyltransferase activity; transferase activity","cytoplasm; cytosol; methylosome; nucleoplasm; nucleus",null,"protein arginine methyltransferase 1","http://www.ncbi.nlm.nih.gov/gene/?term=3276","3276","15469",null,"476411",null,null,"Q99873","Q9JIF0","A0A8I5Y864","A0A8I3PC81","A0A286ZN59","A0A1D5RB22","GO:0005737; GO:0005829; GO:0034709; GO:0005654; GO:0005634","GO:0019899; GO:0044020; GO:0042054; GO:0042802; GO:0008327; GO:0008168; GO:0048273; GO:0008170; GO:0005515; GO:0008276; GO:0016274; GO:0035242; GO:0035241; GO:0003723; GO:1904047; GO:0008757; GO:0016740","GO:0048738; GO:0007166; GO:0043985; GO:0016571; GO:0001701; GO:0032259; GO:0046329; GO:0045653; GO:0031175; GO:0018216; GO:0008284; GO:0045648; GO:0046985; GO:1900745; GO:0051260; GO:0006479; GO:0045652; GO:0008380; GO:0019082","PTHR11006:SF54","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5187|UniProtKB=Q99873"]
["PRMT4 (CARM1)",null,"CARM1","63","rb",null,1,1,1,1,1,1,"# 1094",".cAMP., .CCP., .CP., .CSP., .GPCR., .OP., .OPA., .OT., .ST., .TRASR.",null,"HISTONE-ARGININE METHYLTRANSFERASE CARM1","aging; chromatin organization; histone methylation; methylation; negative regulation of dendrite development; peptidyl-arginine methylation; positive regulation of cell population proliferation; positive regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase I; regulation of DNA-templated transcription; regulation of intracellular estrogen receptor signaling pathway; regulation of mRNA binding; replication fork reversal; response to cAMP","beta-catenin binding; DNA-binding transcription factor binding; histone arginine N-methyltransferase activity; histone H3R17 methyltransferase activity; histone H3R2 methyltransferase activity; histone methyltransferase activity; lysine-acetylated histone binding; methyltransferase activity; nuclear receptor coactivator activity; protein binding; protein methyltransferase activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; transcription cis-regulatory region binding; transcription coactivator activity; transferase activity","chromosome; cytoplasm; cytosol; nuclear replication fork; nucleoplasm; nucleus",null,"coactivator associated arginine methyltransferase 1","http://www.ncbi.nlm.nih.gov/gene/?term=10498","10498","59035","363026",null,null,null,"Q86X55","Q9WVG6","Q4AE70","A0A8I3PCS1","A0A286ZLV5","A0A5F7ZFA9","GO:0005694; GO:0005737; GO:0005829; GO:0043596; GO:0005654; GO:0005634","GO:0008013; GO:0140297; GO:0008469; GO:0035642; GO:0070611; GO:0042054; GO:0070577; GO:0008168; GO:0030374; GO:0005515; GO:0008276; GO:0016274; GO:0035242; GO:0000976; GO:0003713; GO:0016740","GO:0007568; GO:0006325; GO:0016571; GO:0032259; GO:2000171; GO:0018216; GO:0008284; GO:0045600; GO:0045943; GO:0006355; GO:0033146; GO:1902415; GO:0071932; GO:0051591","PTHR11006:SF51","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=23393|UniProtKB=Q86X55"]
["Progesterone Receptor A/B",null,"PGR","118, 90","rb",null,2,8,"n/a","n/a","n/a","n/a","# 2662",".BRC., .CANCER., .CCP., .CP., .CSP., .OP., .OPA., .OT., .ST., .TRASR.","Gonadotropin releasing hormone receptor pathway","PROGESTERONE RECEPTOR","cell-cell signaling; epithelial cell maturation; glandular epithelial cell maturation; intracellular steroid hormone receptor signaling pathway; lung alveolus development; mammary gland development; negative regulation of gene expression; ovulation from ovarian follicle; paracrine signaling; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; regulation of DNA-templated transcription; regulation of epithelial cell proliferation; regulation of transcription by RNA polymerase II; signal transduction; steroid hormone mediated signaling pathway; tertiary branching involved in mammary gland duct morphogenesis","ATPase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; identical protein binding; lipid binding; metal ion binding; nuclear receptor activity; nuclear steroid receptor activity; nucleic acid binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; steroid binding; transcription coactivator binding; zinc ion binding","chromatin; cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus",null,"progesterone receptor","http://www.ncbi.nlm.nih.gov/gene/?term=5241","5241","18667","25154","403621",null,null,"P06401","Q00175","E0YJE6","Q9GLW0","A0A287BA88","F6ZBA4","GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0005741; GO:0005739; GO:0005654; GO:0005634","GO:0051117; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0042802; GO:0008289; GO:0046872; GO:0004879; GO:0003707; GO:0003676; GO:0005515; GO:0000978; GO:0043565; GO:0005496; GO:0001223; GO:0008270","GO:0007267; GO:0002070; GO:0002071; GO:0030518; GO:0048286; GO:0030879; GO:0010629; GO:0001542; GO:0038001; GO:0010628; GO:0045944; GO:0050847; GO:0006355; GO:0050678; GO:0006357; GO:0007165; GO:0043401; GO:0060748","PTHR48092:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8910|UniProtKB=P06401","P06664"]
["Progesterone Receptor B",null,"PGR","99","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1244",".BRC., .CANCER., .CCP., .CP., .CSP., .OP., .OPA., .OT., .ST., .TRASR.","Gonadotropin releasing hormone receptor pathway","PROGESTERONE RECEPTOR","cell-cell signaling; epithelial cell maturation; glandular epithelial cell maturation; intracellular steroid hormone receptor signaling pathway; lung alveolus development; mammary gland development; negative regulation of gene expression; ovulation from ovarian follicle; paracrine signaling; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; regulation of DNA-templated transcription; regulation of epithelial cell proliferation; regulation of transcription by RNA polymerase II; signal transduction; steroid hormone mediated signaling pathway; tertiary branching involved in mammary gland duct morphogenesis","ATPase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; identical protein binding; lipid binding; metal ion binding; nuclear receptor activity; nuclear steroid receptor activity; nucleic acid binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; steroid binding; transcription coactivator binding; zinc ion binding","chromatin; cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus",null,"progesterone receptor","http://www.ncbi.nlm.nih.gov/gene/?term=5241","5241","18667","25154","403621",null,null,"P06401","Q00175","E0YJE6","Q9GLW0","A0A287BA88","F6ZBA4","GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0005741; GO:0005739; GO:0005654; GO:0005634","GO:0051117; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0042802; GO:0008289; GO:0046872; GO:0004879; GO:0003707; GO:0003676; GO:0005515; GO:0000978; GO:0043565; GO:0005496; GO:0001223; GO:0008270","GO:0007267; GO:0002070; GO:0002071; GO:0030518; GO:0048286; GO:0030879; GO:0010629; GO:0001542; GO:0038001; GO:0010628; GO:0045944; GO:0050847; GO:0006355; GO:0050678; GO:0006357; GO:0007165; GO:0043401; GO:0060748","PTHR48092:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8910|UniProtKB=P06401","P06664"]
["Protein phosphatase inhibitor 2 (PPP1R2)",null,"PPP1R2","23","gt",null,7,6,"n/a","n/a","n/a","n/a","# 0387",".CSP., .OPA., .ST.",null,"PROTEIN PHOSPHATASE INHIBITOR 2-RELATED","carbohydrate metabolic process; generation of precursor metabolites and energy; glycogen metabolic process; regulation of phosphoprotein phosphatase activity; regulation of signal transduction","molecular function inhibitor activity; protein binding; protein phosphatase inhibitor activity; protein serine/threonine phosphatase inhibitor activity",null,"Phosphatases","protein phosphatase 1 regulatory inhibitor subunit 2","http://www.ncbi.nlm.nih.gov/gene/?term=5504","5504","66849","192361","478605",null,"708936","P41236","Q9DCL8","P50411","A0A8I3QAG8",null,"F6T1H7",null,"GO:0140678; GO:0005515; GO:0004864; GO:0004865","GO:0005975; GO:0006091; GO:0005977; GO:0043666; GO:0009966","PTHR12398:SF35","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9288|UniProtKB=P41236"]
["PSD95",null,"DLG4","95","ms",null,7,4,"n/a","n/a","n/a","n/a","# 0524",".CSP., .DEV., .DI., .HIPPO., .HUNT., .OP., .OPA., .ST.","Huntington disease","DISKS LARGE HOMOLOG 4","AMPA glutamate receptor clustering; cell-cell adhesion; cellular response to potassium ion; cerebral cortex development; chemical synaptic transmission; dendritic spine morphogenesis; dendritic spine organization; establishment of protein localization; establishment or maintenance of epithelial cell apical/basal polarity; learning; locomotory exploration behavior; maintenance of postsynaptic density structure; negative regulation of receptor internalization; nervous system development; neuromuscular process controlling balance; neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of AMPA glutamate receptor clustering; positive regulation of cytosolic calcium ion concentration; positive regulation of dendrite morphogenesis; positive regulation of excitatory postsynaptic potential; positive regulation of neuron projection arborization; positive regulation of protein tyrosine kinase activity; positive regulation of synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; protein localization to synapse; protein-containing complex assembly; receptor clustering; receptor localization to synapse; regulation of grooming behavior; regulation of long-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity; regulation of NMDA receptor activity; signal transduction; social behavior; synaptic vesicle maturation; vocalization behavior","acetylcholine receptor binding; beta-1 adrenergic receptor binding; beta-2 adrenergic receptor binding; D1 dopamine receptor binding; frizzled binding; glutamate receptor binding; immunoglobulin binding; ionotropic glutamate receptor binding; kinase binding; kinesin binding; neuroligin family protein binding; P2Y1 nucleotide receptor binding; PDZ domain binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; protein-containing complex binding; scaffold protein binding; signaling receptor binding; structural constituent of postsynaptic density","adherens junction; AMPA glutamate receptor complex; axon; cell junction; cell periphery; cell projection; cell-cell junction; cerebellar mossy fiber; cortical cytoskeleton; cytoplasm; cytosol; dendrite; dendrite cytoplasm; dendritic branch; dendritic spine; endocytic vesicle membrane; endoplasmic reticulum; excitatory synapse; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; juxtaparanode region of axon; membrane; mitochondrion; neuromuscular junction; neuron projection; neuron projection terminus; neuron spine; plasma membrane; postsynapse; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynapse; proximal dendrite; synapse; synaptic membrane; synaptic vesicle; voltage-gated potassium channel complex","Synaptic signaling","discs large MAGUK scaffold protein 4","http://www.ncbi.nlm.nih.gov/gene/?term=1742","1742","13385",null,null,null,null,"P78352","Q62108","A0A0G2K7F5","A0A8I3PGP6",null,"A0A5F7ZSF6","GO:0005912; GO:0032281; GO:0030424; GO:0030054; GO:0071944; GO:0042995; GO:0005911; GO:0044300; GO:0030863; GO:0005737; GO:0005829; GO:0030425; GO:0032839; GO:0044307; GO:0043197; GO:0030666; GO:0005783; GO:0060076; GO:0031234; GO:0098978; GO:0044224; GO:0016020; GO:0005739; GO:0031594; GO:0043005; GO:0044306; GO:0044309; GO:0005886; GO:0098794; GO:0014069; GO:0098839; GO:0045211; GO:0098793; GO:1990635; GO:0045202; GO:0097060; GO:0008021; GO:0008076","GO:0033130; GO:0031697; GO:0031698; GO:0031748; GO:0005109; GO:0035254; GO:0019865; GO:0035255; GO:0019900; GO:0019894; GO:0097109; GO:0031812; GO:0030165; GO:0005515; GO:0008022; GO:0019901; GO:0019903; GO:0044877; GO:0097110; GO:0005102; GO:0098919","GO:0097113; GO:0098609; GO:0035865; GO:0021987; GO:0007268; GO:0060997; GO:0097061; GO:0045184; GO:0045197; GO:0007612; GO:0035641; GO:0099562; GO:0002091; GO:0007399; GO:0050885; GO:0099645; GO:1904719; GO:0007204; GO:0050775; GO:2000463; GO:0150012; GO:0061098; GO:0050806; GO:0098970; GO:0035418; GO:0065003; GO:0043113; GO:0097120; GO:2000821; GO:0048169; GO:0048168; GO:2000310; GO:0007165; GO:0035176; GO:0016188; GO:0071625","PTHR23119:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2903|UniProtKB=P78352","P00029"]
["PSD95",null,"DLG4","95","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2227",".CSP., .DEV., .DI., .HIPPO., .HUNT., .OP., .OPA., .ST.","Huntington disease","DISKS LARGE HOMOLOG 4","AMPA glutamate receptor clustering; cell-cell adhesion; cellular response to potassium ion; cerebral cortex development; chemical synaptic transmission; dendritic spine morphogenesis; dendritic spine organization; establishment of protein localization; establishment or maintenance of epithelial cell apical/basal polarity; learning; locomotory exploration behavior; maintenance of postsynaptic density structure; negative regulation of receptor internalization; nervous system development; neuromuscular process controlling balance; neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of AMPA glutamate receptor clustering; positive regulation of cytosolic calcium ion concentration; positive regulation of dendrite morphogenesis; positive regulation of excitatory postsynaptic potential; positive regulation of neuron projection arborization; positive regulation of protein tyrosine kinase activity; positive regulation of synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; protein localization to synapse; protein-containing complex assembly; receptor clustering; receptor localization to synapse; regulation of grooming behavior; regulation of long-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity; regulation of NMDA receptor activity; signal transduction; social behavior; synaptic vesicle maturation; vocalization behavior","acetylcholine receptor binding; beta-1 adrenergic receptor binding; beta-2 adrenergic receptor binding; D1 dopamine receptor binding; frizzled binding; glutamate receptor binding; immunoglobulin binding; ionotropic glutamate receptor binding; kinase binding; kinesin binding; neuroligin family protein binding; P2Y1 nucleotide receptor binding; PDZ domain binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; protein-containing complex binding; scaffold protein binding; signaling receptor binding; structural constituent of postsynaptic density","adherens junction; AMPA glutamate receptor complex; axon; cell junction; cell periphery; cell projection; cell-cell junction; cerebellar mossy fiber; cortical cytoskeleton; cytoplasm; cytosol; dendrite; dendrite cytoplasm; dendritic branch; dendritic spine; endocytic vesicle membrane; endoplasmic reticulum; excitatory synapse; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; juxtaparanode region of axon; membrane; mitochondrion; neuromuscular junction; neuron projection; neuron projection terminus; neuron spine; plasma membrane; postsynapse; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynapse; proximal dendrite; synapse; synaptic membrane; synaptic vesicle; voltage-gated potassium channel complex","Synaptic signaling","discs large MAGUK scaffold protein 4","http://www.ncbi.nlm.nih.gov/gene/?term=1742","1742","13385",null,null,null,null,"P78352","Q62108","A0A0G2K7F5","A0A8I3PGP6",null,"A0A5F7ZSF6","GO:0005912; GO:0032281; GO:0030424; GO:0030054; GO:0071944; GO:0042995; GO:0005911; GO:0044300; GO:0030863; GO:0005737; GO:0005829; GO:0030425; GO:0032839; GO:0044307; GO:0043197; GO:0030666; GO:0005783; GO:0060076; GO:0031234; GO:0098978; GO:0044224; GO:0016020; GO:0005739; GO:0031594; GO:0043005; GO:0044306; GO:0044309; GO:0005886; GO:0098794; GO:0014069; GO:0098839; GO:0045211; GO:0098793; GO:1990635; GO:0045202; GO:0097060; GO:0008021; GO:0008076","GO:0033130; GO:0031697; GO:0031698; GO:0031748; GO:0005109; GO:0035254; GO:0019865; GO:0035255; GO:0019900; GO:0019894; GO:0097109; GO:0031812; GO:0030165; GO:0005515; GO:0008022; GO:0019901; GO:0019903; GO:0044877; GO:0097110; GO:0005102; GO:0098919","GO:0097113; GO:0098609; GO:0035865; GO:0021987; GO:0007268; GO:0060997; GO:0097061; GO:0045184; GO:0045197; GO:0007612; GO:0035641; GO:0099562; GO:0002091; GO:0007399; GO:0050885; GO:0099645; GO:1904719; GO:0007204; GO:0050775; GO:2000463; GO:0150012; GO:0061098; GO:0050806; GO:0098970; GO:0035418; GO:0065003; GO:0043113; GO:0097120; GO:2000821; GO:0048169; GO:0048168; GO:2000310; GO:0007165; GO:0035176; GO:0016188; GO:0071625","PTHR23119:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2903|UniProtKB=P78352","P00029"]
["PTCH1",null,"PTCH1","210-180","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1437",".cAMP., .CANCER., .CANPTHW., .CCP., .CCY., .CP., .CSP., .DEV., .DRR., .GPCR., .HHSP., .OP., .OPA., .OT., .ST., .TRASR.","Hedgehog signaling pathway","PROTEIN PATCHED HOMOLOG 1","animal organ morphogenesis; brain development; branching involved in ureteric bud morphogenesis; cell differentiation involved in kidney development; cell fate determination; cell proliferation involved in metanephros development; cellular response to cholesterol; commissural neuron axon guidance; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; embryonic limb morphogenesis; embryonic organ development; epidermal cell fate specification; epidermis development; epithelial cell proliferation; glucose homeostasis; heart morphogenesis; hindlimb morphogenesis; in utero embryonic development; keratinocyte proliferation; limb morphogenesis; liver regeneration; mammary gland development; mammary gland duct morphogenesis; mammary gland epithelial cell differentiation; metanephric collecting duct development; negative regulation of cell division; negative regulation of cell population proliferation; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of multicellular organism growth; negative regulation of osteoblast differentiation; negative regulation of smoothened signaling pathway; negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; neural plate axis specification; neural tube closure; neural tube formation; neural tube patterning; pattern specification process; pharyngeal system development; positive regulation of cholesterol efflux; positive regulation of DNA-templated transcription; positive regulation of epidermal cell differentiation; prostate gland development; protein localization to plasma membrane; protein processing; regulation of cell population proliferation; regulation of growth; regulation of mitotic cell cycle; regulation of protein localization; regulation of smoothened signaling pathway; response to chlorate; response to estradiol; response to mechanical stimulus; response to organic cyclic compound; response to retinoic acid; response to xenobiotic stimulus; signal transduction; smooth muscle tissue development; smoothened signaling pathway; somite development; spermatid development; spinal cord motor neuron differentiation; stem cell proliferation","cholesterol binding; cyclin binding; hedgehog family protein binding; hedgehog receptor activity; heparin binding; patched binding; protein binding; protein-containing complex binding; smoothened binding","apical part of cell; axonal growth cone; caveola; ciliary membrane; cilium; dendritic growth cone; endocytic vesicle membrane; Golgi apparatus; intracellular membrane-bounded organelle; membrane; midbody; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density","Development","patched 1","http://www.ncbi.nlm.nih.gov/gene/?term=5727","5727","19206",null,null,null,null,"Q13635","Q61115","A0A0G2JVB8","A0A8I3MK09","A0A286ZV54","A0A1D5QSK7","GO:0045177; GO:0044295; GO:0005901; GO:0060170; GO:0005929; GO:0044294; GO:0030666; GO:0005794; GO:0043231; GO:0016020; GO:0030496; GO:0005634; GO:0048471; GO:0005886; GO:0014069","GO:0015485; GO:0030332; GO:0097108; GO:0008158; GO:0008201; GO:0005113; GO:0005515; GO:0044877; GO:0005119","GO:0009887; GO:0007420; GO:0001658; GO:0061005; GO:0001709; GO:0072203; GO:0071397; GO:0071679; GO:0021904; GO:0009953; GO:0030326; GO:0048568; GO:0009957; GO:0008544; GO:0050673; GO:0042593; GO:0003007; GO:0035137; GO:0001701; GO:0043616; GO:0035108; GO:0097421; GO:0030879; GO:0060603; GO:0060644; GO:0072205; GO:0051782; GO:0008285; GO:0043433; GO:0045892; GO:0050680; GO:0010839; GO:0040015; GO:0045668; GO:0045879; GO:2000647; GO:0000122; GO:0021997; GO:0001843; GO:0001841; GO:0021532; GO:0007389; GO:0060037; GO:0010875; GO:0045893; GO:0045606; GO:0030850; GO:0072659; GO:0016485; GO:0042127; GO:0040008; GO:0007346; GO:0032880; GO:0008589; GO:0010157; GO:0032355; GO:0009612; GO:0014070; GO:0032526; GO:0009410; GO:0007165; GO:0048745; GO:0007224; GO:0061053; GO:0007286; GO:0021522; GO:0072089","PTHR46022:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9585|UniProtKB=Q13635","P00025"]
["PTCH2",null,"PTCH2","130","rb",null,7,6,7,7,7,7,"# 1763",".CANCER., .CANPTHW., .CCP., .CP., .CSP., .DEV., .HHSP., .OP.",null,"PROTEIN PATCHED HOMOLOG 2","cell fate determination; epidermal cell fate specification; epidermis development; hair cycle; negative regulation of smoothened signaling pathway; positive regulation of epidermal cell differentiation; regulation of cell growth; skin development","hedgehog family protein binding; hedgehog receptor activity; smoothened binding","membrane; plasma membrane","Development","patched 2","http://www.ncbi.nlm.nih.gov/gene/?term=8643","8643","19207",null,"482519",null,null,"Q9Y6C5","O35595",null,"A0A8P0SAB2",null,null,"GO:0016020; GO:0005886","GO:0097108; GO:0008158; GO:0005119","GO:0001709; GO:0009957; GO:0008544; GO:0042633; GO:0045879; GO:0045606; GO:0001558; GO:0043588","PTHR46022:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9586|UniProtKB=Q9Y6C5"]
["PTEN",null,"PTEN","54","rb",null,2,2,8,8,1.1000000000000001,1.1000000000000001,"# 1770",".APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .EGFR., .EMC., .FOXO., .GLI., .HIF., .IMUF., .INFM., .INS., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR., .WNT.","CCKR signaling map; p53 pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2","PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN","apoptotic process; brain morphogenesis; canonical Wnt signaling pathway; cell migration; cell motility; cellular response to electrical stimulus; central nervous system development; central nervous system myelin maintenance; central nervous system neuron axonogenesis; dendritic spine morphogenesis; dentate gyrus development; dephosphorylation; forebrain morphogenesis; heart development; inositol phosphate dephosphorylation; learning or memory; lipid metabolic process; locomotor rhythm; locomotory behavior; multicellular organismal response to stress; negative regulation of axonogenesis; negative regulation of cell cycle G1/S phase transition; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of cell size; negative regulation of cellular senescence; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of dendritic spine morphogenesis; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of excitatory postsynaptic potential; negative regulation of focal adhesion assembly; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of keratinocyte migration; negative regulation of neuron projection development; negative regulation of organ growth; negative regulation of peptidyl-serine phosphorylation; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase B signaling; negative regulation of protein phosphorylation; negative regulation of synaptic vesicle clustering; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of wound healing, spreading of epidermal cells; nervous system development; neuron-neuron synaptic transmission; phosphatidylinositol 3-kinase signaling; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; positive regulation of cell population proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of excitatory postsynaptic potential; positive regulation of TRAIL-activated apoptotic signaling pathway; positive regulation of ubiquitin protein ligase activity; positive regulation of ubiquitin-dependent protein catabolic process; postsynaptic density assembly; prepulse inhibition; presynaptic membrane assembly; protein dephosphorylation; protein kinase B signaling; protein stabilization; regulation of cellular component size; regulation of neuron projection development; regulation of protein kinase B signaling; regulation of protein stability; rhythmic synaptic transmission; social behavior; synapse assembly; synapse maturation","anaphase-promoting complex binding; enzyme binding; hydrolase activity; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; lipid binding; myosin phosphatase activity; PDZ domain binding; phosphatase activity; phosphatidylinositol phosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; ubiquitin-specific protease binding","apical plasma membrane; cell projection; cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendritic spine; extracellular region; myelin sheath adaxonal region; neuron projection; nucleoplasm; nucleus; plasma membrane; PML body; postsynaptic density; Schmidt-Lanterman incisure; synapse","Metabolism / cell cycle control","phosphatase and tensin homolog","http://www.ncbi.nlm.nih.gov/gene/?term=5728","5728","19211","50557",null,null,null,"P60484","O08586","O54857",null,"A0A5G2QK45","A0A1D5QNK5","GO:0016324; GO:0042995; GO:0005737; GO:0009898; GO:0005829; GO:0043197; GO:0005576; GO:0035749; GO:0043005; GO:0005654; GO:0005634; GO:0005886; GO:0016605; GO:0014069; GO:0043220; GO:0045202","GO:0010997; GO:0019899; GO:0016787; GO:0042802; GO:0051717; GO:0008289; GO:0017018; GO:0030165; GO:0016791; GO:0052866; GO:0016314; GO:0051800; GO:0004438; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:1990381","GO:0006915; GO:0048854; GO:0060070; GO:0016477; GO:0048870; GO:0071257; GO:0007417; GO:0032286; GO:0021955; GO:0060997; GO:0021542; GO:0016311; GO:0048853; GO:0007507; GO:0046855; GO:0007611; GO:0006629; GO:0045475; GO:0007626; GO:0033555; GO:0050771; GO:1902807; GO:0030336; GO:0008285; GO:0045792; GO:2000773; GO:0045736; GO:0061002; GO:0010719; GO:0070373; GO:0090394; GO:0051895; GO:2000134; GO:0051548; GO:0010977; GO:0046621; GO:0033137; GO:0014067; GO:0051898; GO:0001933; GO:2000808; GO:1904706; GO:1903690; GO:0007399; GO:0007270; GO:0014065; GO:0006661; GO:0046856; GO:0008284; GO:0051091; GO:2000463; GO:1903984; GO:1904668; GO:2000060; GO:0097107; GO:0060134; GO:0097105; GO:0006470; GO:0043491; GO:0050821; GO:0032535; GO:0010975; GO:0051896; GO:0031647; GO:0060024; GO:0035176; GO:0007416; GO:0060074","PTHR12305:SF81","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9588|UniProtKB=P60484","P06959; P00059; P00033; P00030; P00031; P00048; P04398"]
["PTEN - non-phospho","Ser380/Thr382/Thr383","PTEN","55","rb",null,1,1.1000000000000001,"n/a","n/a","n/a","n/a","# 2488",".APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .EGFR., .EMC., .FOXO., .GLI., .HIF., .IMUF., .INFM., .INS., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR., .WNT.","CCKR signaling map; p53 pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2","PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN","apoptotic process; brain morphogenesis; canonical Wnt signaling pathway; cell migration; cell motility; cellular response to electrical stimulus; central nervous system development; central nervous system myelin maintenance; central nervous system neuron axonogenesis; dendritic spine morphogenesis; dentate gyrus development; dephosphorylation; forebrain morphogenesis; heart development; inositol phosphate dephosphorylation; learning or memory; lipid metabolic process; locomotor rhythm; locomotory behavior; multicellular organismal response to stress; negative regulation of axonogenesis; negative regulation of cell cycle G1/S phase transition; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of cell size; negative regulation of cellular senescence; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of dendritic spine morphogenesis; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of excitatory postsynaptic potential; negative regulation of focal adhesion assembly; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of keratinocyte migration; negative regulation of neuron projection development; negative regulation of organ growth; negative regulation of peptidyl-serine phosphorylation; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase B signaling; negative regulation of protein phosphorylation; negative regulation of synaptic vesicle clustering; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of wound healing, spreading of epidermal cells; nervous system development; neuron-neuron synaptic transmission; phosphatidylinositol 3-kinase signaling; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; positive regulation of cell population proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of excitatory postsynaptic potential; positive regulation of TRAIL-activated apoptotic signaling pathway; positive regulation of ubiquitin protein ligase activity; positive regulation of ubiquitin-dependent protein catabolic process; postsynaptic density assembly; prepulse inhibition; presynaptic membrane assembly; protein dephosphorylation; protein kinase B signaling; protein stabilization; regulation of cellular component size; regulation of neuron projection development; regulation of protein kinase B signaling; regulation of protein stability; rhythmic synaptic transmission; social behavior; synapse assembly; synapse maturation","anaphase-promoting complex binding; enzyme binding; hydrolase activity; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; lipid binding; myosin phosphatase activity; PDZ domain binding; phosphatase activity; phosphatidylinositol phosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; ubiquitin-specific protease binding","apical plasma membrane; cell projection; cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendritic spine; extracellular region; myelin sheath adaxonal region; neuron projection; nucleoplasm; nucleus; plasma membrane; PML body; postsynaptic density; Schmidt-Lanterman incisure; synapse",null,"phosphatase and tensin homolog","http://www.ncbi.nlm.nih.gov/gene/?term=5728","5728","19211","50557",null,null,null,"P60484","O08586","O54857",null,"A0A5G2QK45","A0A1D5QNK5","GO:0016324; GO:0042995; GO:0005737; GO:0009898; GO:0005829; GO:0043197; GO:0005576; GO:0035749; GO:0043005; GO:0005654; GO:0005634; GO:0005886; GO:0016605; GO:0014069; GO:0043220; GO:0045202","GO:0010997; GO:0019899; GO:0016787; GO:0042802; GO:0051717; GO:0008289; GO:0017018; GO:0030165; GO:0016791; GO:0052866; GO:0016314; GO:0051800; GO:0004438; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:1990381","GO:0006915; GO:0048854; GO:0060070; GO:0016477; GO:0048870; GO:0071257; GO:0007417; GO:0032286; GO:0021955; GO:0060997; GO:0021542; GO:0016311; GO:0048853; GO:0007507; GO:0046855; GO:0007611; GO:0006629; GO:0045475; GO:0007626; GO:0033555; GO:0050771; GO:1902807; GO:0030336; GO:0008285; GO:0045792; GO:2000773; GO:0045736; GO:0061002; GO:0010719; GO:0070373; GO:0090394; GO:0051895; GO:2000134; GO:0051548; GO:0010977; GO:0046621; GO:0033137; GO:0014067; GO:0051898; GO:0001933; GO:2000808; GO:1904706; GO:1903690; GO:0007399; GO:0007270; GO:0014065; GO:0006661; GO:0046856; GO:0008284; GO:0051091; GO:2000463; GO:1903984; GO:1904668; GO:2000060; GO:0097107; GO:0060134; GO:0097105; GO:0006470; GO:0043491; GO:0050821; GO:0032535; GO:0010975; GO:0051896; GO:0031647; GO:0060024; GO:0035176; GO:0007416; GO:0060074","PTHR12305:SF81","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9588|UniProtKB=P60484","P06959; P00059; P00033; P00030; P00031; P00048; P04398"]
["PTEN - phospho","Ser380","PTEN","54","rb",null,2,2,1,6,2,1,"# 1940",".APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .EGFR., .EMC., .FOXO., .GLI., .HIF., .IMUF., .INFM., .INS., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR., .WNT.","CCKR signaling map; p53 pathway; Insulin/IGF pathway-protein kinase B signaling cascade; Hypoxia response via HIF activation; Inflammation mediated by chemokine and cytokine signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2","PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN","apoptotic process; brain morphogenesis; canonical Wnt signaling pathway; cell migration; cell motility; cellular response to electrical stimulus; central nervous system development; central nervous system myelin maintenance; central nervous system neuron axonogenesis; dendritic spine morphogenesis; dentate gyrus development; dephosphorylation; forebrain morphogenesis; heart development; inositol phosphate dephosphorylation; learning or memory; lipid metabolic process; locomotor rhythm; locomotory behavior; multicellular organismal response to stress; negative regulation of axonogenesis; negative regulation of cell cycle G1/S phase transition; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of cell size; negative regulation of cellular senescence; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of dendritic spine morphogenesis; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of excitatory postsynaptic potential; negative regulation of focal adhesion assembly; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of keratinocyte migration; negative regulation of neuron projection development; negative regulation of organ growth; negative regulation of peptidyl-serine phosphorylation; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase B signaling; negative regulation of protein phosphorylation; negative regulation of synaptic vesicle clustering; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of wound healing, spreading of epidermal cells; nervous system development; neuron-neuron synaptic transmission; phosphatidylinositol 3-kinase signaling; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; positive regulation of cell population proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of excitatory postsynaptic potential; positive regulation of TRAIL-activated apoptotic signaling pathway; positive regulation of ubiquitin protein ligase activity; positive regulation of ubiquitin-dependent protein catabolic process; postsynaptic density assembly; prepulse inhibition; presynaptic membrane assembly; protein dephosphorylation; protein kinase B signaling; protein stabilization; regulation of cellular component size; regulation of neuron projection development; regulation of protein kinase B signaling; regulation of protein stability; rhythmic synaptic transmission; social behavior; synapse assembly; synapse maturation","anaphase-promoting complex binding; enzyme binding; hydrolase activity; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; lipid binding; myosin phosphatase activity; PDZ domain binding; phosphatase activity; phosphatidylinositol phosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; ubiquitin-specific protease binding","apical plasma membrane; cell projection; cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendritic spine; extracellular region; myelin sheath adaxonal region; neuron projection; nucleoplasm; nucleus; plasma membrane; PML body; postsynaptic density; Schmidt-Lanterman incisure; synapse","Metabolism / cell cycle control","phosphatase and tensin homolog","http://www.ncbi.nlm.nih.gov/gene/?term=5728","5728","19211","50557",null,null,null,"P60484","O08586","O54857",null,"A0A5G2QK45","A0A1D5QNK5","GO:0016324; GO:0042995; GO:0005737; GO:0009898; GO:0005829; GO:0043197; GO:0005576; GO:0035749; GO:0043005; GO:0005654; GO:0005634; GO:0005886; GO:0016605; GO:0014069; GO:0043220; GO:0045202","GO:0010997; GO:0019899; GO:0016787; GO:0042802; GO:0051717; GO:0008289; GO:0017018; GO:0030165; GO:0016791; GO:0052866; GO:0016314; GO:0051800; GO:0004438; GO:0004721; GO:0005515; GO:0004722; GO:0004725; GO:1990381","GO:0006915; GO:0048854; GO:0060070; GO:0016477; GO:0048870; GO:0071257; GO:0007417; GO:0032286; GO:0021955; GO:0060997; GO:0021542; GO:0016311; GO:0048853; GO:0007507; GO:0046855; GO:0007611; GO:0006629; GO:0045475; GO:0007626; GO:0033555; GO:0050771; GO:1902807; GO:0030336; GO:0008285; GO:0045792; GO:2000773; GO:0045736; GO:0061002; GO:0010719; GO:0070373; GO:0090394; GO:0051895; GO:2000134; GO:0051548; GO:0010977; GO:0046621; GO:0033137; GO:0014067; GO:0051898; GO:0001933; GO:2000808; GO:1904706; GO:1903690; GO:0007399; GO:0007270; GO:0014065; GO:0006661; GO:0046856; GO:0008284; GO:0051091; GO:2000463; GO:1903984; GO:1904668; GO:2000060; GO:0097107; GO:0060134; GO:0097105; GO:0006470; GO:0043491; GO:0050821; GO:0032535; GO:0010975; GO:0051896; GO:0031647; GO:0060024; GO:0035176; GO:0007416; GO:0060074","PTHR12305:SF81","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9588|UniProtKB=P60484","P06959; P00059; P00033; P00030; P00031; P00048; P04398"]
["PTPN7 (LC-PTP, HEPTP)",null,"PTPN7","40","rb",null,6,2,6,6,2,2,"# 0336",".CSP., .MAPK., .OPA., .RTK., .ST.",null,"TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 7","dephosphorylation; MAPK cascade; protein dephosphorylation","hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity","cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; microtubule cytoskeleton; mitotic spindle; nucleoplasm","Tyrosine phosphatase","protein tyrosine phosphatase non-receptor type 7","http://www.ncbi.nlm.nih.gov/gene/?term=5778","5778","320139","246781",null,null,null,"P35236","Q8BUM3","P49445","A0A8I3NY60",null,"F6TEC2","GO:0005737; GO:0009898; GO:0005856; GO:0005829; GO:0015630; GO:0072686; GO:0005654","GO:0016787; GO:0004726; GO:0016791; GO:0004721; GO:0005515; GO:0004725","GO:0016311; GO:0000165; GO:0006470","PTHR19134:SF527","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9659|UniProtKB=P35236"]
["PTPN7 (LC-PTP, HEPTP)",null,"PTPN7","40","rb",null,2,4,8,8,8,8,"# 0496",".CSP., .MAPK., .OPA., .RTK., .ST.",null,"TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 7","dephosphorylation; MAPK cascade; protein dephosphorylation","hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity","cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; microtubule cytoskeleton; mitotic spindle; nucleoplasm","Tyrosine phosphatase","protein tyrosine phosphatase non-receptor type 7","http://www.ncbi.nlm.nih.gov/gene/?term=5778","5778","320139","246781",null,null,null,"P35236","Q8BUM3","P49445","A0A8I3NY60",null,"F6TEC2","GO:0005737; GO:0009898; GO:0005856; GO:0005829; GO:0015630; GO:0072686; GO:0005654","GO:0016787; GO:0004726; GO:0016791; GO:0004721; GO:0005515; GO:0004725","GO:0016311; GO:0000165; GO:0006470","PTHR19134:SF527","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9659|UniProtKB=P35236"]
["PTP-PEST (PTPN12, PTN12)",null,"PTPN12","88","ms",null,7,4,"n/a","n/a","n/a","n/a","# 0407",".CSP., .EGFR., .ErbB., .INT., .OPA., .PDGF., .RTK., .ST.","Integrin signalling pathway","TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12","cellular response to epidermal growth factor stimulus; dephosphorylation; negative regulation of ERBB signaling pathway; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; regulation of epidermal growth factor receptor signaling pathway; tissue regeneration","hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding","anchoring junction; cell projection; cytoplasm; cytosol; focal adhesion; nucleoplasm; nucleus; podosome","Tyrosine phosphatase","protein tyrosine phosphatase non-receptor type 12","http://www.ncbi.nlm.nih.gov/gene/?term=5782","5782","19248",null,null,null,"721538","Q05209","P35831","A0A0G2KAC5",null,"A0A287AF36","A0A1D5RIQ8","GO:0070161; GO:0042995; GO:0005737; GO:0005829; GO:0005925; GO:0005654; GO:0005634; GO:0002102","GO:0016787; GO:0004726; GO:0016791; GO:0004721; GO:0005515; GO:0004725; GO:0017124","GO:0071364; GO:0016311; GO:1901185; GO:2000587; GO:0035335; GO:0006470; GO:0042058; GO:0042246","PTHR45983:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9645|UniProtKB=Q05209","P00034"]
["PTPRB (RPTP beta)",null,"PTPRB","250","ms",null,2,7,2,7,7,7,"# 0526",".ANG., .CANCER., .CSP., .MIG., .OP., .OPA., .OT., .ST.","Angiogenesis","RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA","angiogenesis; dephosphorylation; glial cell migration; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; phosphate-containing compound metabolic process; protein dephosphorylation; protein modification process","cadherin binding; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity","membrane; plasma membrane; receptor complex; specific granule membrane; tertiary granule membrane","Angiogenesis","protein tyrosine phosphatase receptor type B","http://www.ncbi.nlm.nih.gov/gene/?term=5787","5787","19263","314843","481162",null,null,"P23467","B2RU80","A0A0G2K2W0","A0A8P0N3P5","A0A287A9P8","A0A1D5R2H4","GO:0016020; GO:0005886; GO:0043235; GO:0035579; GO:0070821","GO:0045296; GO:0016787; GO:0016791; GO:0004721; GO:0005515; GO:0004725; GO:0005001","GO:0001525; GO:0016311; GO:0008347; GO:1990264; GO:0006796; GO:0006470; GO:0036211","PTHR46957:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9665|UniProtKB=P23467","P00005"]
["PTPRC (CD45)",null,"PTPRC","180","rb",null,7,7,"n/a","n/a","n/a","n/a","# 0444",".APO., .BCR., .CCP., .CCY., .CD., .CP., .CSP., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .ST., .STAT., .TCD., .TCR., .TMAT., .TRASR., .VIR.","T cell activation; B cell activation; JAK/STAT signaling pathway","RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C","alpha-beta T cell proliferation; B cell differentiation; B cell proliferation; B cell receptor signaling pathway; bone marrow development; calcium-mediated signaling using intracellular calcium source; cell cycle phase transition; cell surface receptor signaling pathway; cellular response to extracellular stimulus; defense response to virus; dephosphorylation; DN2 thymocyte differentiation; extrinsic apoptotic signaling pathway; gamma-delta T cell differentiation; hematopoietic progenitor cell differentiation; heterotypic cell-cell adhesion; leukocyte cell-cell adhesion; MAPK cascade; natural killer cell differentiation; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cytokine-mediated signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 production; negative regulation of microglial cell activation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein autophosphorylation; negative regulation of protein kinase activity; negative regulation of protein tyrosine kinase activity; negative regulation of T cell mediated cytotoxicity; negative thymic T cell selection; peptidyl-tyrosine phosphorylation; plasma membrane raft distribution; positive regulation of alpha-beta T cell proliferation; positive regulation of antigen receptor-mediated signaling pathway; positive regulation of B cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of gamma-delta T cell differentiation; positive regulation of hematopoietic stem cell migration; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of immunoglobulin production; positive regulation of interleukin-2 production; positive regulation of isotype switching to IgG isotypes; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of protein tyrosine phosphatase activity; positive regulation of stem cell proliferation; positive regulation of T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive regulation of tumor necrosis factor production; positive thymic T cell selection; protein autophosphorylation; protein dephosphorylation; regulation of cell cycle; regulation of extrinsic apoptotic signaling pathway; regulation of gene expression; regulation of humoral immune response mediated by circulating immunoglobulin; regulation of interleukin-8 production; regulation of phagocytosis; regulation of protein tyrosine kinase activity; regulation of receptor signaling pathway via JAK-STAT; release of sequestered calcium ion into cytosol; response to gamma radiation; stem cell development; T cell activation; T cell differentiation; T cell proliferation; T cell receptor signaling pathway","ankyrin binding; heparan sulfate proteoglycan binding; heparin binding; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; signaling receptor binding; spectrin binding; transmembrane receptor protein tyrosine phosphatase activity","bleb; cell periphery; cell surface; cytoplasmic side of plasma membrane; external side of plasma membrane; extracellular exosome; focal adhesion; membrane; membrane microdomain; membrane raft; plasma membrane; secretory granule membrane","Cell cycle control","protein tyrosine phosphatase receptor type C","http://www.ncbi.nlm.nih.gov/gene/?term=5788","5788","19264","24699","490255",null,null,"P08575","P06800","P04157","A0A8I3PQA9","A0A287A482","A0A1D5Q7H1","GO:0032059; GO:0071944; GO:0009986; GO:0009898; GO:0009897; GO:0070062; GO:0005925; GO:0016020; GO:0098857; GO:0045121; GO:0005886; GO:0030667","GO:0030506; GO:0043395; GO:0008201; GO:0016787; GO:0016791; GO:0004721; GO:0005515; GO:0019901; GO:0004725; GO:0005102; GO:0030507; GO:0005001","GO:0046633; GO:0030183; GO:0042100; GO:0050853; GO:0048539; GO:0035584; GO:0044770; GO:0007166; GO:0031668; GO:0051607; GO:0016311; GO:1904155; GO:0097191; GO:0042492; GO:0002244; GO:0034113; GO:0007159; GO:0000165; GO:0001779; GO:0006933; GO:0001960; GO:0070373; GO:0032703; GO:1903979; GO:0050732; GO:0031953; GO:0006469; GO:0061099; GO:0001915; GO:0045060; GO:0018108; GO:0044855; GO:0046641; GO:0050857; GO:0030890; GO:0070374; GO:2001238; GO:1905451; GO:0045588; GO:2000473; GO:0002925; GO:0002639; GO:0032743; GO:0048304; GO:0043406; GO:0043410; GO:0050731; GO:0045860; GO:1903615; GO:2000648; GO:0045582; GO:0001916; GO:0002711; GO:0042102; GO:0032760; GO:0045059; GO:0046777; GO:0006470; GO:0051726; GO:2001236; GO:0010468; GO:0002923; GO:0032677; GO:0050764; GO:0061097; GO:0046425; GO:0051209; GO:0010332; GO:0048864; GO:0042110; GO:0030217; GO:0042098; GO:0050852","PTHR19134:SF539","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9666|UniProtKB=P08575","P00053; P00010; P00038"]
["PTPRC (CD45)",null,"PTPRC","220-180","ms",null,1,7,"n/a","n/a","n/a","n/a","# 0500",".APO., .BCR., .CCP., .CCY., .CD., .CP., .CSP., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .ST., .STAT., .TCD., .TCR., .TMAT., .TRASR., .VIR.","T cell activation; B cell activation; JAK/STAT signaling pathway","RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C","alpha-beta T cell proliferation; B cell differentiation; B cell proliferation; B cell receptor signaling pathway; bone marrow development; calcium-mediated signaling using intracellular calcium source; cell cycle phase transition; cell surface receptor signaling pathway; cellular response to extracellular stimulus; defense response to virus; dephosphorylation; DN2 thymocyte differentiation; extrinsic apoptotic signaling pathway; gamma-delta T cell differentiation; hematopoietic progenitor cell differentiation; heterotypic cell-cell adhesion; leukocyte cell-cell adhesion; MAPK cascade; natural killer cell differentiation; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cytokine-mediated signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 production; negative regulation of microglial cell activation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein autophosphorylation; negative regulation of protein kinase activity; negative regulation of protein tyrosine kinase activity; negative regulation of T cell mediated cytotoxicity; negative thymic T cell selection; peptidyl-tyrosine phosphorylation; plasma membrane raft distribution; positive regulation of alpha-beta T cell proliferation; positive regulation of antigen receptor-mediated signaling pathway; positive regulation of B cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of gamma-delta T cell differentiation; positive regulation of hematopoietic stem cell migration; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of immunoglobulin production; positive regulation of interleukin-2 production; positive regulation of isotype switching to IgG isotypes; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of protein tyrosine phosphatase activity; positive regulation of stem cell proliferation; positive regulation of T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive regulation of tumor necrosis factor production; positive thymic T cell selection; protein autophosphorylation; protein dephosphorylation; regulation of cell cycle; regulation of extrinsic apoptotic signaling pathway; regulation of gene expression; regulation of humoral immune response mediated by circulating immunoglobulin; regulation of interleukin-8 production; regulation of phagocytosis; regulation of protein tyrosine kinase activity; regulation of receptor signaling pathway via JAK-STAT; release of sequestered calcium ion into cytosol; response to gamma radiation; stem cell development; T cell activation; T cell differentiation; T cell proliferation; T cell receptor signaling pathway","ankyrin binding; heparan sulfate proteoglycan binding; heparin binding; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; signaling receptor binding; spectrin binding; transmembrane receptor protein tyrosine phosphatase activity","bleb; cell periphery; cell surface; cytoplasmic side of plasma membrane; external side of plasma membrane; extracellular exosome; focal adhesion; membrane; membrane microdomain; membrane raft; plasma membrane; secretory granule membrane","Cell cycle control","protein tyrosine phosphatase receptor type C","http://www.ncbi.nlm.nih.gov/gene/?term=5788","5788","19264","24699","490255",null,null,"P08575","P06800","P04157","A0A8I3PQA9","A0A287A482","A0A1D5Q7H1","GO:0032059; GO:0071944; GO:0009986; GO:0009898; GO:0009897; GO:0070062; GO:0005925; GO:0016020; GO:0098857; GO:0045121; GO:0005886; GO:0030667","GO:0030506; GO:0043395; GO:0008201; GO:0016787; GO:0016791; GO:0004721; GO:0005515; GO:0019901; GO:0004725; GO:0005102; GO:0030507; GO:0005001","GO:0046633; GO:0030183; GO:0042100; GO:0050853; GO:0048539; GO:0035584; GO:0044770; GO:0007166; GO:0031668; GO:0051607; GO:0016311; GO:1904155; GO:0097191; GO:0042492; GO:0002244; GO:0034113; GO:0007159; GO:0000165; GO:0001779; GO:0006933; GO:0001960; GO:0070373; GO:0032703; GO:1903979; GO:0050732; GO:0031953; GO:0006469; GO:0061099; GO:0001915; GO:0045060; GO:0018108; GO:0044855; GO:0046641; GO:0050857; GO:0030890; GO:0070374; GO:2001238; GO:1905451; GO:0045588; GO:2000473; GO:0002925; GO:0002639; GO:0032743; GO:0048304; GO:0043406; GO:0043410; GO:0050731; GO:0045860; GO:1903615; GO:2000648; GO:0045582; GO:0001916; GO:0002711; GO:0042102; GO:0032760; GO:0045059; GO:0046777; GO:0006470; GO:0051726; GO:2001236; GO:0010468; GO:0002923; GO:0032677; GO:0050764; GO:0061097; GO:0046425; GO:0051209; GO:0010332; GO:0048864; GO:0042110; GO:0030217; GO:0042098; GO:0050852","PTHR19134:SF539","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9666|UniProtKB=P08575","P00053; P00010; P00038"]
["PTPRR ((PTP-SL, PTP13)",null,"PTPRR","74, 51, 47","rb",null,2,2,1,6,2,2,"# 0414",".CSP., .ErbB., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .ST.",null,"RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE R","dephosphorylation; ERBB2 signaling pathway; in utero embryonic development; negative regulation of epithelial cell migration; negative regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; regulation of homophilic cell adhesion; signal transduction","hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity","cell junction; cytoplasm; cytosol; extracellular space; membrane; perinuclear region of cytoplasm; plasma membrane","MAPK signaling","protein tyrosine phosphatase receptor type R","http://www.ncbi.nlm.nih.gov/gene/?term=5801","5801","19279","94202",null,null,null,"Q15256","Q62132","A0A0G2JYG7","A0A8I3PDD6","A0A8W4FDD2","A0A1D5Q1B5","GO:0030054; GO:0005737; GO:0005829; GO:0005615; GO:0016020; GO:0048471; GO:0005886","GO:0016787; GO:0016791; GO:0004721; GO:0005515; GO:0019901; GO:0004725; GO:0005001","GO:0016311; GO:0038128; GO:0001701; GO:0010633; GO:0070373; GO:0035335; GO:0006470; GO:1903385; GO:0007165","PTHR46198:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9680|UniProtKB=Q15256"]
["Puma",null,"BBC3","23, 18","rb",null,4,2,7,8,6,6,"BG/MP # 087",".APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .DDR., .DEV., .DI., .HIF., .HIPPO., .HUNT., .OP., .OPA., .P53S., .SREME., .ST.",null,null,"activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to ionizing radiation; determination of adult lifespan; execution phase of apoptosis; fibroblast apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; lymphocyte apoptotic process; negative regulation of endoplasmic reticulum calcium ion concentration; negative regulation of growth; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of fibroblast apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of IRE1-mediated unfolded protein response; positive regulation of lymphocyte apoptotic process; positive regulation of neuron apoptotic process; positive regulation of protein homooligomerization; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; positive regulation of T cell apoptotic process; positive regulation of thymocyte apoptotic process; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; release of cytochrome c from mitochondria; release of sequestered calcium ion into cytosol; response to endoplasmic reticulum stress; T cell apoptotic process; toxin transport","protein binding","cytosol; endoplasmic reticulum; mitochondrial outer membrane; mitochondrion; PUMA-BCL-xl complex",null,"BCL2 binding component 3","http://www.ncbi.nlm.nih.gov/gene/?term=27113","27113",null,null,null,null,null,"Q9BXH1",null,null,null,null,"A0A1D5QPX0","GO:0005829; GO:0005783; GO:0005741; GO:0005739; GO:0097143","GO:0005515","GO:0006919; GO:0006915; GO:0006974; GO:0071456; GO:0071479; GO:0008340; GO:0097194; GO:0044346; GO:0097193; GO:0042771; GO:0070059; GO:0070227; GO:0032471; GO:0045926; GO:0043065; GO:2001056; GO:1902237; GO:2000271; GO:2001244; GO:1903896; GO:0070230; GO:0043525; GO:0032464; GO:1900740; GO:0031334; GO:0090200; GO:0070234; GO:0070245; GO:0001844; GO:0001836; GO:0051209; GO:0034976; GO:0070231; GO:1901998"]
["PXR (NR1I2)",null,"NR1I2","50, 45","rb",null,2,6,"n/a","n/a","n/a","n/a","# 1592",".ANG., .CANCER., .CSP., .DRR., .OP., .OPA., .OT., .ST., .TRASR.","Angiogenesis","NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2","cell differentiation; intracellular receptor signaling pathway; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; signal transduction; steroid metabolic process; xenobiotic catabolic process; xenobiotic metabolic process; xenobiotic transport","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; nuclear receptor activity; nuclear receptor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; zinc ion binding","chromatin; intermediate filament cytoskeleton; nuclear body; nucleoplasm; nucleus; transcription regulator complex",null,"nuclear receptor subfamily 1 group I member 2","http://www.ncbi.nlm.nih.gov/gene/?term=8856","8856","18171","84385",null,null,null,"O75469","O54915","Q9R1A7","A0A8I3P3X7","A0A286ZKP7","F6VGK2","GO:0000785; GO:0045111; GO:0016604; GO:0005654; GO:0005634; GO:0005667","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0046872; GO:0004879; GO:0016922; GO:0005515; GO:0000978; GO:0000977; GO:0043565; GO:1990837; GO:0008270","GO:0030154; GO:0030522; GO:0045892; GO:0000122; GO:0045893; GO:0010628; GO:0045944; GO:0006355; GO:0007165; GO:0008202; GO:0042178; GO:0006805; GO:0042908","PTHR24082:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7968|UniProtKB=O75469","P00005"]
["Pyk2 (FAK2)",null,"PTK2B","116","rb",null,1,4,8,8,8,8,"# 0227",".ANG., .APO., .cAMP., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DI., .DRR., .EGFR., .GPCR., .GPROT., .HEPB., .HIF., .IIR., .IMU., .IMUF., .IMUR., .INFM., .INT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .STAT., .TNF., .TRASR., .VEGFS.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","PROTEIN-TYROSINE KINASE 2-BETA","actin filament organization; activation of GTPase activity; activation of Janus kinase activity; adaptive immune response; angiogenesis; apoptotic process; blood vessel endothelial cell migration; bone resorption; cell adhesion; cell differentiation; cell surface receptor signaling pathway; cellular defense response; cellular response to fluid shear stress; cellular response to organic substance; cellular response to retinoic acid; chemokine-mediated signaling pathway; endothelin receptor signaling pathway; epidermal growth factor receptor signaling pathway; focal adhesion assembly; glial cell proliferation; immune system process; innate immune response; integrin-mediated signaling pathway; ionotropic glutamate receptor signaling pathway; long-term synaptic depression; long-term synaptic potentiation; MAPK cascade; marginal zone B cell differentiation; negative regulation of apoptotic process; negative regulation of bone mineralization; negative regulation of cell population proliferation; negative regulation of muscle cell apoptotic process; negative regulation of myeloid cell differentiation; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of potassium ion transport; neuron projection development; oocyte maturation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of B cell chemotaxis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell-matrix adhesion; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA biosynthetic process; positive regulation of endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron projection development; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase activity; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; positive regulation of synaptic transmission, glutamatergic; positive regulation of translation; positive regulation of ubiquitin-dependent protein catabolic process; postsynaptic modulation of chemical synaptic transmission; protein autophosphorylation; protein phosphorylation; protein-containing complex assembly; regulation of actin cytoskeleton reorganization; regulation of calcium-mediated signaling; regulation of cell adhesion; regulation of cell shape; regulation of cellular component organization; regulation of cGMP-mediated signaling; regulation of establishment of cell polarity; regulation of inositol trisphosphate biosynthetic process; regulation of macrophage chemotaxis; regulation of multicellular organismal process; regulation of nitric oxide biosynthetic process; regulation of NMDA receptor activity; regulation of postsynaptic density assembly; regulation of release of sequestered calcium ion into cytosol; regulation of synaptic plasticity; regulation of ubiquitin-dependent protein catabolic process; response to calcium ion; response to cAMP; response to cation stress; response to cocaine; response to ethanol; response to glucose; response to hormone; response to hydrogen peroxide; response to hypoxia; response to immobilization stress; response to ischemia; response to lithium ion; response to mechanical stimulus; response to organonitrogen compound; response to osmotic stress; response to reactive oxygen species; response to xenobiotic stimulus; signal complex assembly; signal transduction; sprouting angiogenesis; stress fiber assembly; transmembrane receptor protein tyrosine kinase signaling pathway; tumor necrosis factor-mediated signaling pathway; vascular endothelial growth factor receptor signaling pathway","3-phosphoinositide-dependent protein kinase binding; ATP binding; calmodulin-dependent protein kinase activity; enzyme binding; kinase activity; NMDA glutamate receptor activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein self-association; protein tyrosine kinase activity; protein-containing complex binding; signaling receptor binding; transferase activity; ubiquitin protein ligase binding","anchoring junction; apical dendrite; axon; cell body; cell cortex; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; glutamatergic synapse; growth cone; lamellipodium; membrane; membrane raft; neuronal cell body; NMDA selective glutamate receptor complex; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynapse; postsynaptic density; postsynaptic density, intracellular component; presynapse; Schaffer collateral - CA1 synapse","Tyrosine kinase / adaptor","protein tyrosine kinase 2 beta","http://www.ncbi.nlm.nih.gov/gene/?term=2185","2185","19229","50646",null,null,null,"Q14289","Q9QVP9","P70600","A0A8I3NL72","A0A287AR80","A0A1D5RKE2","GO:0070161; GO:0097440; GO:0030424; GO:0044297; GO:0005938; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0043197; GO:0031234; GO:0005925; GO:0098978; GO:0030426; GO:0030027; GO:0016020; GO:0045121; GO:0043025; GO:0017146; GO:0005634; GO:0048471; GO:0005886; GO:0098794; GO:0014069; GO:0099092; GO:0098793; GO:0098685","GO:0043423; GO:0005524; GO:0004683; GO:0019899; GO:0016301; GO:0004972; GO:0004715; GO:0000166; GO:0005515; GO:0008022; GO:0004672; GO:0043621; GO:0004713; GO:0044877; GO:0005102; GO:0016740; GO:0031625","GO:0007015; GO:0090630; GO:0042976; GO:0002250; GO:0001525; GO:0006915; GO:0043534; GO:0045453; GO:0007155; GO:0030154; GO:0007166; GO:0006968; GO:0071498; GO:0071310; GO:0071300; GO:0070098; GO:0086100; GO:0007173; GO:0048041; GO:0014009; GO:0002376; GO:0045087; GO:0007229; GO:0035235; GO:0060292; GO:0060291; GO:0000165; GO:0002315; GO:0043066; GO:0030502; GO:0008285; GO:0010656; GO:0045638; GO:0043524; GO:0030279; GO:0043267; GO:0031175; GO:0001556; GO:0038083; GO:0018108; GO:0016310; GO:0030838; GO:0045766; GO:2000538; GO:0030307; GO:0030335; GO:0008284; GO:0001954; GO:0007204; GO:2000573; GO:0010595; GO:0070374; GO:2000463; GO:0046330; GO:0043507; GO:0010976; GO:0045429; GO:0051000; GO:0050731; GO:0043552; GO:0045860; GO:0051247; GO:0001934; GO:2000379; GO:0051968; GO:0045727; GO:2000060; GO:0099170; GO:0046777; GO:0006468; GO:0065003; GO:2000249; GO:0050848; GO:0030155; GO:0008360; GO:0051128; GO:0010752; GO:2000114; GO:0032960; GO:0010758; GO:0051239; GO:0045428; GO:2000310; GO:0099151; GO:0051279; GO:0048167; GO:2000058; GO:0051592; GO:0051591; GO:0043157; GO:0042220; GO:0045471; GO:0009749; GO:0009725; GO:0042542; GO:0001666; GO:0035902; GO:0002931; GO:0010226; GO:0009612; GO:0010243; GO:0006970; GO:0000302; GO:0009410; GO:0007172; GO:0007165; GO:0002040; GO:0043149; GO:0007169; GO:0033209; GO:0048010","PTHR24418:SF94","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9612|UniProtKB=Q14289","P06959; P06664; P00034; P00031"]
["Pyk2 (FAK2) - phospho","Tyr402","PTK2B","116","rb",null,6,1,8,8,8,8,"TK # 099",".ANG., .APO., .cAMP., .CANCER., .CCKR., .CCP., .CD., .CP., .CSP., .DI., .DRR., .EGFR., .GPCR., .GPROT., .HEPB., .HIF., .IIR., .IMU., .IMUF., .IMUR., .INFM., .INT., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .STAT., .TNF., .TRASR., .VEGFS.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","PROTEIN-TYROSINE KINASE 2-BETA","actin filament organization; activation of GTPase activity; activation of Janus kinase activity; adaptive immune response; angiogenesis; apoptotic process; blood vessel endothelial cell migration; bone resorption; cell adhesion; cell differentiation; cell surface receptor signaling pathway; cellular defense response; cellular response to fluid shear stress; cellular response to organic substance; cellular response to retinoic acid; chemokine-mediated signaling pathway; endothelin receptor signaling pathway; epidermal growth factor receptor signaling pathway; focal adhesion assembly; glial cell proliferation; immune system process; innate immune response; integrin-mediated signaling pathway; ionotropic glutamate receptor signaling pathway; long-term synaptic depression; long-term synaptic potentiation; MAPK cascade; marginal zone B cell differentiation; negative regulation of apoptotic process; negative regulation of bone mineralization; negative regulation of cell population proliferation; negative regulation of muscle cell apoptotic process; negative regulation of myeloid cell differentiation; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of potassium ion transport; neuron projection development; oocyte maturation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of B cell chemotaxis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell-matrix adhesion; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA biosynthetic process; positive regulation of endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron projection development; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase activity; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; positive regulation of synaptic transmission, glutamatergic; positive regulation of translation; positive regulation of ubiquitin-dependent protein catabolic process; postsynaptic modulation of chemical synaptic transmission; protein autophosphorylation; protein phosphorylation; protein-containing complex assembly; regulation of actin cytoskeleton reorganization; regulation of calcium-mediated signaling; regulation of cell adhesion; regulation of cell shape; regulation of cellular component organization; regulation of cGMP-mediated signaling; regulation of establishment of cell polarity; regulation of inositol trisphosphate biosynthetic process; regulation of macrophage chemotaxis; regulation of multicellular organismal process; regulation of nitric oxide biosynthetic process; regulation of NMDA receptor activity; regulation of postsynaptic density assembly; regulation of release of sequestered calcium ion into cytosol; regulation of synaptic plasticity; regulation of ubiquitin-dependent protein catabolic process; response to calcium ion; response to cAMP; response to cation stress; response to cocaine; response to ethanol; response to glucose; response to hormone; response to hydrogen peroxide; response to hypoxia; response to immobilization stress; response to ischemia; response to lithium ion; response to mechanical stimulus; response to organonitrogen compound; response to osmotic stress; response to reactive oxygen species; response to xenobiotic stimulus; signal complex assembly; signal transduction; sprouting angiogenesis; stress fiber assembly; transmembrane receptor protein tyrosine kinase signaling pathway; tumor necrosis factor-mediated signaling pathway; vascular endothelial growth factor receptor signaling pathway","3-phosphoinositide-dependent protein kinase binding; ATP binding; calmodulin-dependent protein kinase activity; enzyme binding; kinase activity; NMDA glutamate receptor activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein self-association; protein tyrosine kinase activity; protein-containing complex binding; signaling receptor binding; transferase activity; ubiquitin protein ligase binding","anchoring junction; apical dendrite; axon; cell body; cell cortex; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; glutamatergic synapse; growth cone; lamellipodium; membrane; membrane raft; neuronal cell body; NMDA selective glutamate receptor complex; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynapse; postsynaptic density; postsynaptic density, intracellular component; presynapse; Schaffer collateral - CA1 synapse","Tyrosine kinase / adaptor","protein tyrosine kinase 2 beta","http://www.ncbi.nlm.nih.gov/gene/?term=2185","2185","19229","50646",null,null,null,"Q14289","Q9QVP9","P70600","A0A8I3NL72","A0A287AR80","A0A1D5RKE2","GO:0070161; GO:0097440; GO:0030424; GO:0044297; GO:0005938; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0030425; GO:0043197; GO:0031234; GO:0005925; GO:0098978; GO:0030426; GO:0030027; GO:0016020; GO:0045121; GO:0043025; GO:0017146; GO:0005634; GO:0048471; GO:0005886; GO:0098794; GO:0014069; GO:0099092; GO:0098793; GO:0098685","GO:0043423; GO:0005524; GO:0004683; GO:0019899; GO:0016301; GO:0004972; GO:0004715; GO:0000166; GO:0005515; GO:0008022; GO:0004672; GO:0043621; GO:0004713; GO:0044877; GO:0005102; GO:0016740; GO:0031625","GO:0007015; GO:0090630; GO:0042976; GO:0002250; GO:0001525; GO:0006915; GO:0043534; GO:0045453; GO:0007155; GO:0030154; GO:0007166; GO:0006968; GO:0071498; GO:0071310; GO:0071300; GO:0070098; GO:0086100; GO:0007173; GO:0048041; GO:0014009; GO:0002376; GO:0045087; GO:0007229; GO:0035235; GO:0060292; GO:0060291; GO:0000165; GO:0002315; GO:0043066; GO:0030502; GO:0008285; GO:0010656; GO:0045638; GO:0043524; GO:0030279; GO:0043267; GO:0031175; GO:0001556; GO:0038083; GO:0018108; GO:0016310; GO:0030838; GO:0045766; GO:2000538; GO:0030307; GO:0030335; GO:0008284; GO:0001954; GO:0007204; GO:2000573; GO:0010595; GO:0070374; GO:2000463; GO:0046330; GO:0043507; GO:0010976; GO:0045429; GO:0051000; GO:0050731; GO:0043552; GO:0045860; GO:0051247; GO:0001934; GO:2000379; GO:0051968; GO:0045727; GO:2000060; GO:0099170; GO:0046777; GO:0006468; GO:0065003; GO:2000249; GO:0050848; GO:0030155; GO:0008360; GO:0051128; GO:0010752; GO:2000114; GO:0032960; GO:0010758; GO:0051239; GO:0045428; GO:2000310; GO:0099151; GO:0051279; GO:0048167; GO:2000058; GO:0051592; GO:0051591; GO:0043157; GO:0042220; GO:0045471; GO:0009749; GO:0009725; GO:0042542; GO:0001666; GO:0035902; GO:0002931; GO:0010226; GO:0009612; GO:0010243; GO:0006970; GO:0000302; GO:0009410; GO:0007172; GO:0007165; GO:0002040; GO:0043149; GO:0007169; GO:0033209; GO:0048010","PTHR24418:SF94","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9612|UniProtKB=Q14289","P06959; P06664; P00034; P00031"]
["Pyruvate Dehydrogenase (PDHA1)",null,"PDHA1","43","rb",null,1,2,"n/a","n/a","n/a","n/a","# 2184",".CAMET., .CANCER., .CSP., .HIF., .OP., .SREME.","TCA cycle; Pyruvate metabolism","PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL","acetyl-CoA biosynthetic process from pyruvate; carbohydrate metabolic process; glucose metabolic process; pyruvate metabolic process; tricarboxylic acid cycle","oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; protein binding; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase (NAD+) activity; pyruvate dehydrogenase activity","catalytic complex; intracellular membrane-bounded organelle; mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion; nucleolus; nucleus; pyruvate dehydrogenase complex",null,"pyruvate dehydrogenase E1 subunit alpha 1","http://www.ncbi.nlm.nih.gov/gene/?term=5160","5160","18597",null,null,null,null,"P08559","P35486","D4A5G8",null,"A0A5G2QMB8","F7HBL8","GO:1902494; GO:0043231; GO:0005759; GO:0005967; GO:0005739; GO:0005730; GO:0005634; GO:0045254","GO:0016491; GO:0016624; GO:0005515; GO:0004739; GO:0034604; GO:0004738","GO:0006086; GO:0005975; GO:0006006; GO:0006090; GO:0006099","PTHR11516:SF52","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8806|UniProtKB=P08559","P00051; P02772"]
["Pyruvate Dehydrogenase (PDHA1) - phospho","Ser293","PDHA1","40","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2112",".CAMET., .CANCER., .CSP., .HIF., .OP., .SREME.","TCA cycle; Pyruvate metabolism","PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL","acetyl-CoA biosynthetic process from pyruvate; carbohydrate metabolic process; glucose metabolic process; pyruvate metabolic process; tricarboxylic acid cycle","oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; protein binding; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase (NAD+) activity; pyruvate dehydrogenase activity","catalytic complex; intracellular membrane-bounded organelle; mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion; nucleolus; nucleus; pyruvate dehydrogenase complex",null,"pyruvate dehydrogenase E1 subunit alpha 1","http://www.ncbi.nlm.nih.gov/gene/?term=5160","5160","18597",null,null,null,null,"P08559","P35486","D4A5G8",null,"A0A5G2QMB8","F7HBL8","GO:1902494; GO:0043231; GO:0005759; GO:0005967; GO:0005739; GO:0005730; GO:0005634; GO:0045254","GO:0016491; GO:0016624; GO:0005515; GO:0004739; GO:0034604; GO:0004738","GO:0006086; GO:0005975; GO:0006006; GO:0006090; GO:0006099","PTHR11516:SF52","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8806|UniProtKB=P08559","P00051; P02772"]
["Pyruvate kinase PKLR",null,"PKLR","62","rb",null,1,2,7,8,6,2.1,"# 0626",".cAMP., .CSP., .DRR., .GPCR., .HIF., .INS., .OP., .OPA., .OT., .SREME., .ST.","Pyruvate metabolism; Glycolysis","PYRUVATE KINASE PKLR","ATP biosynthetic process; carbohydrate metabolic process; cellular response to epinephrine stimulus; cellular response to insulin stimulus; glycolytic process; metabolic process; phosphorylation; pyruvate biosynthetic process; response to ATP; response to cAMP; response to glucose; response to heat; response to hypoxia; response to lithium ion; response to metal ion; response to nutrient","ATP binding; catalytic activity; kinase activity; magnesium ion binding; metal ion binding; monosaccharide binding; nucleotide binding; potassium ion binding; protein binding; pyruvate kinase activity; transferase activity","cytoplasm; cytosol; extracellular exosome",null,"pyruvate kinase L/R","http://www.ncbi.nlm.nih.gov/gene/?term=5313","5313",null,"24651","490425",null,"719152","P30613","D3Z2C4","P12928","Q29536","A0A286ZYV7","A0A5F7ZB67","GO:0005737; GO:0005829; GO:0070062","GO:0005524; GO:0003824; GO:0016301; GO:0000287; GO:0046872; GO:0048029; GO:0000166; GO:0030955; GO:0005515; GO:0004743; GO:0016740","GO:0006754; GO:0005975; GO:0071872; GO:0032869; GO:0006096; GO:0008152; GO:0016310; GO:0042866; GO:0033198; GO:0051591; GO:0009749; GO:0009408; GO:0001666; GO:0010226; GO:0010038; GO:0007584","PTHR11817:SF31","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9020|UniProtKB=P30613","P02772; P00024"]
["Pyruvate kinase PKM2",null,"PKM","58","rb",null,2,6,6,7,1,2,"# 0625",".ANG., .CAMET., .CANCER., .CSP., .INS., .OP., .OPA., .OT., .SREME., .ST., .TRASR.","Pyruvate metabolism; Glycolysis","PYRUVATE KINASE PKM","canonical glycolysis; cellular response to insulin stimulus; glycolytic process; metabolic process; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cytoplasmic translation; positive regulation of sprouting angiogenesis; programmed cell death; regulation of translation","ATP binding; cadherin binding; catalytic activity; kinase activity; magnesium ion binding; metal ion binding; MHC class II protein complex binding; mRNA binding; nucleotide binding; potassium ion binding; protein binding; protein tyrosine kinase activity; pyruvate kinase activity; RNA binding; transferase activity","cilium; collagen-containing extracellular matrix; cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular vesicle; ficolin-1-rich granule lumen; mitochondrion; nucleus; rough endoplasmic reticulum; secretory granule lumen; vesicle",null,"pyruvate kinase M1/2","http://www.ncbi.nlm.nih.gov/gene/?term=5315","5315","18746",null,null,null,null,"P14618","P52480","M0RD14","A0A8P0NPE2","A0A286ZI36","A0A1D5R3F4","GO:0005929; GO:0062023; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1903561; GO:1904813; GO:0005739; GO:0005634; GO:0005791; GO:0034774; GO:0031982","GO:0005524; GO:0045296; GO:0003824; GO:0016301; GO:0000287; GO:0046872; GO:0023026; GO:0003729; GO:0000166; GO:0030955; GO:0005515; GO:0004713; GO:0004743; GO:0003723; GO:0016740","GO:0061621; GO:0032869; GO:0006096; GO:0008152; GO:0018108; GO:0016310; GO:2000767; GO:1903672; GO:0012501; GO:0006417","PTHR11817:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9021|UniProtKB=P14618","P02772; P00024"]
["Rab11",null,"RAB11A","25","rb",null,2,2,1.1000000000000001,7,1.1000000000000001,4,"# 1217",".CCP., .CCY., .MIG., .OP., .OT.",null,"RAS-RELATED PROTEIN RAB-11A","amyloid-beta clearance by transcytosis; astral microtubule organization; cell cycle; establishment of protein localization to membrane; establishment of protein localization to organelle; establishment of vesicle localization; exocytosis; exosomal secretion; melanosome transport; mitotic metaphase plate congression; mitotic spindle assembly; multivesicular body assembly; neuron projection development; neurotransmitter receptor transport, endosome to postsynaptic membrane; plasma membrane to endosome transport; positive regulation of epithelial cell migration; positive regulation of G2/M transition of mitotic cell cycle; protein localization to cell surface; protein localization to plasma membrane; protein transport; regulation of cytokinesis; regulation of multivesicular body size; regulation of vesicle-mediated transport; vesicle-mediated transport","G protein activity; GTP binding; GTPase activity; hydrolase activity; microtubule binding; myosin V binding; nucleotide binding; protein binding; syntaxin binding","centriolar satellite; centriole; centrosome; cleavage furrow; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; endosome; extracellular exosome; glutamatergic synapse; Golgi apparatus; intracellular membrane-bounded organelle; kinetochore microtubule; membrane; multivesicular body; phagocytic vesicle; plasma membrane; postsynaptic recycling endosome; protein-containing complex; recycling endosome; recycling endosome membrane; spindle pole; trans-Golgi network; transport vesicle; vesicle","Cytoskeletal signaling","RAB11A, member RAS oncogene family","http://www.ncbi.nlm.nih.gov/gene/?term=8766","8766","53869","81830",null,null,null,"P62491","P62492","P62494",null,null,"A0A1D5RHP6","GO:0034451; GO:0005814; GO:0005813; GO:0032154; GO:0005737; GO:0031410; GO:0030659; GO:0005829; GO:0005768; GO:0070062; GO:0098978; GO:0005794; GO:0043231; GO:0005828; GO:0016020; GO:0005771; GO:0045335; GO:0005886; GO:0098837; GO:0032991; GO:0055037; GO:0055038; GO:0000922; GO:0005802; GO:0030133; GO:0031982","GO:0003925; GO:0005525; GO:0003924; GO:0016787; GO:0008017; GO:0031489; GO:0000166; GO:0005515; GO:0019905","GO:0150093; GO:0030953; GO:0007049; GO:0090150; GO:0072594; GO:0051650; GO:0006887; GO:1990182; GO:0032402; GO:0007080; GO:0090307; GO:0036258; GO:0031175; GO:0098887; GO:0048227; GO:0010634; GO:0010971; GO:0034394; GO:0072659; GO:0015031; GO:0032465; GO:0010796; GO:0060627; GO:0016192","PTHR47979:SF110","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9760|UniProtKB=P62491"]
["Rab25",null,"RAB25","23","rb",null,2,4,8,8,2.1,8,"# 1465",".CCP., .CP., .MIG., .OP., .OT.",null,"RAS-RELATED PROTEIN RAB-25","epithelial cell morphogenesis; exocytosis; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; protein transport; pseudopodium organization; regulation of vesicle-mediated transport; vesicle-mediated transport","GTP binding; GTPase activity; myosin V binding; nucleotide binding; protein binding","cell projection; cytoplasmic vesicle; endosome; extracellular exosome; Golgi apparatus; membrane; plasma membrane; pseudopodium; pseudopodium membrane; recycling endosome","Cytoskeletal signaling","RAB25, member RAS oncogene family","http://www.ncbi.nlm.nih.gov/gene/?term=57111","57111","53868",null,"490418",null,"718131","P57735","Q9WTL2","A0A8I5ZWP2","E2RQ15",null,"F6XEC1","GO:0042995; GO:0031410; GO:0005768; GO:0070062; GO:0005794; GO:0016020; GO:0005886; GO:0031143; GO:0031260; GO:0055037","GO:0005525; GO:0003924; GO:0031489; GO:0000166; GO:0005515","GO:0003382; GO:0006887; GO:0008284; GO:0010634; GO:0015031; GO:0031268; GO:0060627; GO:0016192","PTHR47979:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18238|UniProtKB=P57735"]
["Rac1/cdc42",null,"RAC1, CDC42","21","rb",null,1,1,1,1,1,1,"# 2413",".BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .EGFR., .FGFR., .GPCR., .GPROT., .HUNT., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .PAC., .PI3K., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TOLL., .TRASR., .UBI., .VEGFS., .WNT.","Axon guidance mediated by Slit/Robo; CCKR signaling map; T cell activation; p38 MAPK pathway; Axon guidance mediated by netrin; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Cytoskeletal regulation by Rho GTPase; Integrin signalling pathway; Axon guidance mediated by semaphorins; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1; CELL DIVISION CONTROL PROTEIN 42 HOMOLOG","actin cytoskeleton organization; actin filament organization; actin filament polymerization; anatomical structure morphogenesis; cell adhesion; cell migration; cell motility; cell projection assembly; cell-matrix adhesion; cortical cytoskeleton organization; engulfment of apoptotic cell; establishment or maintenance of cell polarity; hepatocyte growth factor receptor signaling pathway; inflammatory response; intracellular signal transduction; lamellipodium assembly; localization; localization within membrane; motor neuron axon guidance; negative regulation of fibroblast migration; negative regulation of interleukin-23 production; negative regulation of receptor-mediated endocytosis; neuron migration; positive regulation of cell-substrate adhesion; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of lamellipodium assembly; positive regulation of microtubule polymerization; positive regulation of neutrophil chemotaxis; positive regulation of protein phosphorylation; positive regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; Rac protein signal transduction; regulation of actin cytoskeleton organization; regulation of cell migration; regulation of cell shape; regulation of cell size; regulation of hydrogen peroxide metabolic process; regulation of lamellipodium assembly; regulation of neutrophil migration; regulation of nitric oxide biosynthetic process; regulation of respiratory burst; regulation of stress fiber assembly; respiratory burst; response to wounding; ruffle assembly; ruffle organization; semaphorin-plexin signaling pathway; small GTPase mediated signal transduction; sphingosine-1-phosphate receptor signaling pathway; substrate adhesion-dependent cell spreading; Wnt signaling pathway, planar cell polarity pathway; adherens junction organization; cardiac conduction system development; cardiac neural crest cell migration involved in outflow tract morphogenesis; Cdc42 protein signal transduction; cell differentiation; cell junction assembly; cellular response to type II interferon; dendritic cell migration; dendritic spine morphogenesis; embryonic heart tube development; endocytosis; endothelin receptor signaling pathway involved in heart process; establishment of epithelial cell apical/basal polarity; establishment of Golgi localization; establishment of localization in cell; establishment or maintenance of apical/basal cell polarity; filopodium assembly; Golgi organization; heart contraction; integrin-mediated signaling pathway; macrophage differentiation; modification of synaptic structure; modulation by host of viral process; negative regulation of protein-containing complex assembly; nervous system development; neuron fate determination; neuropilin signaling pathway; nuclear migration; nucleus localization; organelle transport along microtubule; phagocytosis, engulfment; positive regulation of actin cytoskeleton reorganization; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cellular component organization; positive regulation of cytokinesis; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of filopodium assembly; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of pinocytosis; positive regulation of pseudopodium assembly; protein localization; protein phosphorylation; protein ubiquitination; regulation of attachment of spindle microtubules to kinetochore; regulation of filopodium assembly; regulation of mitotic nuclear division; regulation of postsynapse organization; regulation of protein binding; substantia nigra development","enzyme binding; G protein activity; GTP binding; GTPase activity; hydrolase activity; molecular adaptor activity; nucleotide binding; protein binding; protein kinase binding; protein-containing complex binding; Rho GDP-dissociation inhibitor binding; thioesterase binding; apolipoprotein A-I receptor binding; GBD domain binding; GTP-dependent protein binding; identical protein binding; ubiquitin protein ligase activity","actin filament; cell cortex; cell projection; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic vesicle; cytoskeleton; cytosol; dendrite; dendritic spine; endoplasmic reticulum membrane; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; ficolin-1-rich granule membrane; focal adhesion; glutamatergic synapse; lamellipodium; melanosome; membrane; NADPH oxidase complex; nucleus; plasma membrane; postsynapse; recycling endosome membrane; ruffle membrane; secretory granule membrane; synapse; trans-Golgi network; apical part of cell; cell leading edge; cell periphery; cell-cell junction; centrosome; filopodium; Golgi membrane; Golgi transport complex; leading edge membrane; membrane-bounded organelle; microtubule organizing center; midbody; mitotic spindle; neuron projection; neuronal cell body; phagocytic vesicle; protein-containing complex; spindle; spindle midzone; storage vacuole","Cytoskeletal signaling","Rac family small GTPase 1; cell division cycle 42","http://www.ncbi.nlm.nih.gov/gene/?term=5879, http://www.ncbi.nlm.nih.gov/gene/?term=998","5879, 998","19353, 12540","NA, 64465","NA, 403934","","","P63000, P60953","P63001, P60766","A0A0G2K0X4, Q8CFN2","A0A8I3N6F6, P60952","A0A5S6GXN2","F6RBZ7","GO:0005884; GO:0005938; GO:0042995; GO:0005737; GO:0036464; GO:0031410; GO:0005856; GO:0005829; GO:0030425; GO:0043197; GO:0005789; GO:0070062; GO:0031234; GO:0101003; GO:0005925; GO:0098978; GO:0030027; GO:0042470; GO:0016020; GO:0043020; GO:0005634; GO:0005886; GO:0098794; GO:0055038; GO:0032587; GO:0030667; GO:0045202; GO:0005802; GO:0045177; GO:0031252; GO:0071944; GO:0005911; GO:0005813; GO:0030175; GO:0000139; GO:0017119; GO:0031256; GO:0043227; GO:0005815; GO:0030496; GO:0072686; GO:0043005; GO:0043025; GO:0045335; GO:0032991; GO:0005819; GO:0051233; GO:0000322","GO:0019899; GO:0003925; GO:0005525; GO:0003924; GO:0016787; GO:0060090; GO:0000166; GO:0005515; GO:0019901; GO:0044877; GO:0051022; GO:0031996; GO:0034191; GO:0032427; GO:0030742; GO:0042802; GO:0061630","GO:0030036; GO:0007015; GO:0030041; GO:0009653; GO:0007155; GO:0016477; GO:0048870; GO:0030031; GO:0007160; GO:0030865; GO:0043652; GO:0007163; GO:0048012; GO:0006954; GO:0035556; GO:0030032; GO:0051179; GO:0051668; GO:0008045; GO:0010764; GO:0032707; GO:0048261; GO:0001764; GO:0010811; GO:0010595; GO:0051894; GO:0010592; GO:0031116; GO:0090023; GO:0001934; GO:0035025; GO:0051496; GO:1900026; GO:0016601; GO:0032956; GO:0030334; GO:0008360; GO:0008361; GO:0010310; GO:0010591; GO:1902622; GO:0045428; GO:0060263; GO:0051492; GO:0045730; GO:0009611; GO:0097178; GO:0031529; GO:0071526; GO:0007264; GO:0003376; GO:0034446; GO:0060071; GO:0034332; GO:0003161; GO:0003253; GO:0032488; GO:0030154; GO:0034329; GO:0071346; GO:0036336; GO:0060997; GO:0035050; GO:0006897; GO:0086101; GO:0045198; GO:0051683; GO:0051649; GO:0035088; GO:0046847; GO:0007030; GO:0060047; GO:0007229; GO:0030225; GO:0099563; GO:0044788; GO:0031333; GO:0007399; GO:0048664; GO:0038189; GO:0007097; GO:0051647; GO:0072384; GO:0006911; GO:2000251; GO:0030307; GO:0030335; GO:0051130; GO:0032467; GO:0060501; GO:0051491; GO:0043410; GO:0043552; GO:0048549; GO:0031274; GO:0008104; GO:0006468; GO:0016567; GO:0051988; GO:0051489; GO:0007088; GO:0099175; GO:0043393; GO:0021762","PTHR24072:SF105; PTHR24072:SF136","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9801|UniProtKB=P63000; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1736|UniProtKB=P60953","P00008; P06959; P00053; P05918; P00009; P00010; P00056; P06664; P00021; P04393; P00029; P00016; P00034; P00007; P00018; P00031"]
["Rac1/cdc42 - phospho","Ser71","RAC1, CDC42","28","rb",null,2,1.1000000000000001,4,4,4,4,"# 1476",".BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .EGFR., .FGFR., .GPCR., .GPROT., .HUNT., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .PAC., .PI3K., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TOLL., .TRASR., .UBI., .VEGFS., .WNT.","Axon guidance mediated by Slit/Robo; CCKR signaling map; T cell activation; p38 MAPK pathway; Axon guidance mediated by netrin; B cell activation; VEGF signaling pathway; Gonadotropin releasing hormone receptor pathway; FGF signaling pathway; Ras Pathway; Huntington disease; Cytoskeletal regulation by Rho GTPase; Integrin signalling pathway; Axon guidance mediated by semaphorins; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1; CELL DIVISION CONTROL PROTEIN 42 HOMOLOG","actin cytoskeleton organization; actin filament organization; actin filament polymerization; anatomical structure morphogenesis; cell adhesion; cell migration; cell motility; cell projection assembly; cell-matrix adhesion; cortical cytoskeleton organization; engulfment of apoptotic cell; establishment or maintenance of cell polarity; hepatocyte growth factor receptor signaling pathway; inflammatory response; intracellular signal transduction; lamellipodium assembly; localization; localization within membrane; motor neuron axon guidance; negative regulation of fibroblast migration; negative regulation of interleukin-23 production; negative regulation of receptor-mediated endocytosis; neuron migration; positive regulation of cell-substrate adhesion; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of lamellipodium assembly; positive regulation of microtubule polymerization; positive regulation of neutrophil chemotaxis; positive regulation of protein phosphorylation; positive regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; Rac protein signal transduction; regulation of actin cytoskeleton organization; regulation of cell migration; regulation of cell shape; regulation of cell size; regulation of hydrogen peroxide metabolic process; regulation of lamellipodium assembly; regulation of neutrophil migration; regulation of nitric oxide biosynthetic process; regulation of respiratory burst; regulation of stress fiber assembly; respiratory burst; response to wounding; ruffle assembly; ruffle organization; semaphorin-plexin signaling pathway; small GTPase mediated signal transduction; sphingosine-1-phosphate receptor signaling pathway; substrate adhesion-dependent cell spreading; Wnt signaling pathway, planar cell polarity pathway; adherens junction organization; cardiac conduction system development; cardiac neural crest cell migration involved in outflow tract morphogenesis; Cdc42 protein signal transduction; cell differentiation; cell junction assembly; cellular response to type II interferon; dendritic cell migration; dendritic spine morphogenesis; embryonic heart tube development; endocytosis; endothelin receptor signaling pathway involved in heart process; establishment of epithelial cell apical/basal polarity; establishment of Golgi localization; establishment of localization in cell; establishment or maintenance of apical/basal cell polarity; filopodium assembly; Golgi organization; heart contraction; integrin-mediated signaling pathway; macrophage differentiation; modification of synaptic structure; modulation by host of viral process; negative regulation of protein-containing complex assembly; nervous system development; neuron fate determination; neuropilin signaling pathway; nuclear migration; nucleus localization; organelle transport along microtubule; phagocytosis, engulfment; positive regulation of actin cytoskeleton reorganization; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cellular component organization; positive regulation of cytokinesis; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of filopodium assembly; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of pinocytosis; positive regulation of pseudopodium assembly; protein localization; protein phosphorylation; protein ubiquitination; regulation of attachment of spindle microtubules to kinetochore; regulation of filopodium assembly; regulation of mitotic nuclear division; regulation of postsynapse organization; regulation of protein binding; substantia nigra development","enzyme binding; G protein activity; GTP binding; GTPase activity; hydrolase activity; molecular adaptor activity; nucleotide binding; protein binding; protein kinase binding; protein-containing complex binding; Rho GDP-dissociation inhibitor binding; thioesterase binding; apolipoprotein A-I receptor binding; GBD domain binding; GTP-dependent protein binding; identical protein binding; ubiquitin protein ligase activity","actin filament; cell cortex; cell projection; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic vesicle; cytoskeleton; cytosol; dendrite; dendritic spine; endoplasmic reticulum membrane; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; ficolin-1-rich granule membrane; focal adhesion; glutamatergic synapse; lamellipodium; melanosome; membrane; NADPH oxidase complex; nucleus; plasma membrane; postsynapse; recycling endosome membrane; ruffle membrane; secretory granule membrane; synapse; trans-Golgi network; apical part of cell; cell leading edge; cell periphery; cell-cell junction; centrosome; filopodium; Golgi membrane; Golgi transport complex; leading edge membrane; membrane-bounded organelle; microtubule organizing center; midbody; mitotic spindle; neuron projection; neuronal cell body; phagocytic vesicle; protein-containing complex; spindle; spindle midzone; storage vacuole","Cytoskeletal signaling","Rac family small GTPase 1; cell division cycle 42","http://www.ncbi.nlm.nih.gov/gene/?term=5879, http://www.ncbi.nlm.nih.gov/gene/?term=998","5879, 998","19353, 12540","NA, 64465","NA, 403934","","","P63000, P60953","P63001, P60766","A0A0G2K0X4, Q8CFN2","A0A8I3N6F6, P60952","A0A5S6GXN2","F6RBZ7","GO:0005884; GO:0005938; GO:0042995; GO:0005737; GO:0036464; GO:0031410; GO:0005856; GO:0005829; GO:0030425; GO:0043197; GO:0005789; GO:0070062; GO:0031234; GO:0101003; GO:0005925; GO:0098978; GO:0030027; GO:0042470; GO:0016020; GO:0043020; GO:0005634; GO:0005886; GO:0098794; GO:0055038; GO:0032587; GO:0030667; GO:0045202; GO:0005802; GO:0045177; GO:0031252; GO:0071944; GO:0005911; GO:0005813; GO:0030175; GO:0000139; GO:0017119; GO:0031256; GO:0043227; GO:0005815; GO:0030496; GO:0072686; GO:0043005; GO:0043025; GO:0045335; GO:0032991; GO:0005819; GO:0051233; GO:0000322","GO:0019899; GO:0003925; GO:0005525; GO:0003924; GO:0016787; GO:0060090; GO:0000166; GO:0005515; GO:0019901; GO:0044877; GO:0051022; GO:0031996; GO:0034191; GO:0032427; GO:0030742; GO:0042802; GO:0061630","GO:0030036; GO:0007015; GO:0030041; GO:0009653; GO:0007155; GO:0016477; GO:0048870; GO:0030031; GO:0007160; GO:0030865; GO:0043652; GO:0007163; GO:0048012; GO:0006954; GO:0035556; GO:0030032; GO:0051179; GO:0051668; GO:0008045; GO:0010764; GO:0032707; GO:0048261; GO:0001764; GO:0010811; GO:0010595; GO:0051894; GO:0010592; GO:0031116; GO:0090023; GO:0001934; GO:0035025; GO:0051496; GO:1900026; GO:0016601; GO:0032956; GO:0030334; GO:0008360; GO:0008361; GO:0010310; GO:0010591; GO:1902622; GO:0045428; GO:0060263; GO:0051492; GO:0045730; GO:0009611; GO:0097178; GO:0031529; GO:0071526; GO:0007264; GO:0003376; GO:0034446; GO:0060071; GO:0034332; GO:0003161; GO:0003253; GO:0032488; GO:0030154; GO:0034329; GO:0071346; GO:0036336; GO:0060997; GO:0035050; GO:0006897; GO:0086101; GO:0045198; GO:0051683; GO:0051649; GO:0035088; GO:0046847; GO:0007030; GO:0060047; GO:0007229; GO:0030225; GO:0099563; GO:0044788; GO:0031333; GO:0007399; GO:0048664; GO:0038189; GO:0007097; GO:0051647; GO:0072384; GO:0006911; GO:2000251; GO:0030307; GO:0030335; GO:0051130; GO:0032467; GO:0060501; GO:0051491; GO:0043410; GO:0043552; GO:0048549; GO:0031274; GO:0008104; GO:0006468; GO:0016567; GO:0051988; GO:0051489; GO:0007088; GO:0099175; GO:0043393; GO:0021762","PTHR24072:SF105; PTHR24072:SF136","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9801|UniProtKB=P63000; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1736|UniProtKB=P60953","P00008; P06959; P00053; P05918; P00009; P00010; P00056; P06664; P00021; P04393; P00029; P00016; P00034; P00007; P00018; P00031"]
["RACK1",null,"RACK1","35","ms",null,1,1,1,1,1,1,"# 1590",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HHSP., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR., .UBI., .WNT.",null,"RECEPTOR OF ACTIVATED PROTEIN C KINASE 1","activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; cell cycle; cellular response to glucose stimulus; cellular response to growth factor stimulus; cytoplasmic translation; gastrulation; negative regulation of cell growth; negative regulation of endoplasmic reticulum unfolded protein response; negative regulation of gene expression; negative regulation of hydrogen peroxide-induced neuron death; negative regulation of peptidyl-serine phosphorylation; negative regulation of phagocytosis; negative regulation of protein binding; negative regulation of protein kinase B signaling; negative regulation of protein tyrosine kinase activity; negative regulation of smoothened signaling pathway; negative regulation of translation; negative regulation of Wnt signaling pathway; pigmentation; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of gastrulation; positive regulation of Golgi to plasma membrane protein transport; positive regulation of GTPase activity; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial depolarization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein phosphorylation; positive regulation of protein-containing complex assembly; protein ubiquitination; regulation of cell cycle; regulation of cell division; regulation of establishment of cell polarity; regulation of protein localization; regulation of translation; rescue of stalled ribosome; rhythmic process; translation","BH3 domain binding; cadherin binding; cyclin binding; cysteine-type endopeptidase activator activity involved in apoptotic process; enzyme binding; ion channel inhibitor activity; molecular adaptor activity; protein binding; protein homodimerization activity; protein kinase C binding; protein phosphatase binding; protein tyrosine kinase inhibitor activity; receptor tyrosine kinase binding; ribosome binding; RNA binding; SH2 domain binding; signaling adaptor activity; signaling receptor binding; translation regulator activity","cell body; cell projection; cytoplasm; cytosol; cytosolic small ribosomal subunit; dendrite; extracellular exosome; IRE1-RACK1-PP2A complex; membrane; midbody; mitochondrion; neuron projection; neuronal cell body; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; phagocytic cup; plasma membrane; ribonucleoprotein complex; ribosome; small ribosomal subunit",null,"receptor for activated C kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=10399","10399","14694","83427",null,"397605",null,"P63244","P68040","P63245","A0A8I3MR98","P63246","G7MV11","GO:0044297; GO:0042995; GO:0005737; GO:0005829; GO:0022627; GO:0030425; GO:0070062; GO:1990630; GO:0016020; GO:0030496; GO:0005739; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0043204; GO:0048471; GO:0001891; GO:0005886; GO:1990904; GO:0005840; GO:0015935","GO:0051434; GO:0045296; GO:0030332; GO:0008656; GO:0019899; GO:0008200; GO:0060090; GO:0005515; GO:0042803; GO:0005080; GO:0019903; GO:0030292; GO:0030971; GO:0043022; GO:0003723; GO:0042169; GO:0035591; GO:0005102; GO:0045182","GO:0006919; GO:0006915; GO:0007049; GO:0071333; GO:0071363; GO:0002181; GO:0007369; GO:0030308; GO:1900102; GO:0010629; GO:1903208; GO:0033137; GO:0050765; GO:0032091; GO:0051898; GO:0061099; GO:0045879; GO:0017148; GO:0030178; GO:0043473; GO:0043065; GO:0030335; GO:0051343; GO:2000543; GO:0042998; GO:0043547; GO:2001244; GO:0051901; GO:0032436; GO:0001934; GO:0031334; GO:0016567; GO:0051726; GO:0051302; GO:2000114; GO:0032880; GO:0006417; GO:0072344; GO:0048511; GO:0006412","PTHR19868:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=4399|UniProtKB=P63244"]
["Rad23B",null,"RAD23B","58","rb",null,2,2,2,6,2,2,"# 0984",".CD., .CSP., .DDR., .DREP.",null,"UV EXCISION REPAIR PROTEIN RAD23 HOMOLOG B","cellular response to DNA damage stimulus; cellular response to interleukin-7; cellular response to stress; DNA repair; embryonic organ development; nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteasomal ubiquitin-dependent protein catabolic process; spermatogenesis","damaged DNA binding; DNA damage sensor activity; molecular function activator activity; polyubiquitin modification-dependent protein binding; proteasome binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; single-stranded DNA binding; transcription cis-regulatory region binding; ubiquitin binding","cytoplasm; cytosol; nucleoplasm; nucleus; proteasome complex; XPC complex","Protein stability","RAD23 homolog B, nucleotide excision repair protein","http://www.ncbi.nlm.nih.gov/gene/?term=5887","5887","19359","298012","481656",null,null,"P54727","P54728","Q4KMA2","A0A8P0S8J3","A0A8W4FJS5","F6W0K0","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0000502; GO:0071942","GO:0003684; GO:0140612; GO:0140677; GO:0031593; GO:0070628; GO:0005515; GO:0000978; GO:0061629; GO:0003697; GO:0000976; GO:0043130","GO:0006974; GO:0098761; GO:0033554; GO:0006281; GO:0048568; GO:0006289; GO:0043161; GO:0032434; GO:0007283","PTHR10621:SF13","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9813|UniProtKB=P54727"]
["Rad50",null,"RAD50","153","rb",null,6.1,4,7,7,4,1.1000000000000001,"# 1367",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .OP., .OPA., .ST.",null,"DNA REPAIR PROTEIN RAD50","cell cycle; cellular response to DNA damage stimulus; chromosome organization involved in meiotic cell cycle; DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA strand resection involved in replication fork processing; double-strand break repair; homologous recombination; meiotic cell cycle; mitotic G2/M transition checkpoint; negative regulation of telomere capping; nucleic acid phosphodiester bond hydrolysis; organelle organization; positive regulation of kinase activity; positive regulation of protein autophosphorylation; positive regulation of telomere maintenance; reciprocal meiotic recombination; regulation of mitotic recombination; telomere maintenance; telomere maintenance via recombination; telomere maintenance via telomerase; telomeric 3' overhang formation","3'-5' exonuclease activity; ATP binding; ATP hydrolysis activity; ATP-dependent DNA damage sensor activity; DNA binding; DNA helicase activity; double-stranded telomeric DNA binding; G-quadruplex DNA binding; hydrolase activity; identical protein binding; metal ion binding; nucleotide binding; protein binding; protein-macromolecule adaptor activity; single-stranded DNA endodeoxyribonuclease activity; single-stranded telomeric DNA binding","BRCA1-C complex; chromosomal region; chromosome; chromosome, telomeric region; condensed nuclear chromosome; membrane; Mre11 complex; nucleoplasm; nucleus; site of double-strand break","DNA damage","RAD50 double strand break repair protein","http://www.ncbi.nlm.nih.gov/gene/?term=10111","10111",null,null,null,null,null,"Q92878",null,null,"A0A8I3N5C0","A0A286ZKH5","A0A1D5QMS8","GO:0070533; GO:0098687; GO:0005694; GO:0000781; GO:0000794; GO:0016020; GO:0030870; GO:0005654; GO:0005634; GO:0035861","GO:0008408; GO:0005524; GO:0016887; GO:0140664; GO:0003677; GO:0003678; GO:0003691; GO:0051880; GO:0016787; GO:0042802; GO:0046872; GO:0000166; GO:0005515; GO:0030674; GO:0000014; GO:0043047","GO:0007049; GO:0006974; GO:0070192; GO:0000729; GO:0032508; GO:0006310; GO:0006281; GO:0110025; GO:0006302; GO:0035825; GO:0051321; GO:0044818; GO:1904354; GO:0090305; GO:0006996; GO:0033674; GO:0031954; GO:0032206; GO:0007131; GO:0000019; GO:0000723; GO:0000722; GO:0007004; GO:0031860","PTHR18867:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9816|UniProtKB=Q92878"]
["Rad51",null,"RAD51","37","rb",null,6,4,2.1,7,8,8,"# 0735",".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CSP., .DDR., .DREP., .DRR., .OP., .OPA., .OT., .PAC., .ST., .UBI.",null,"DNA REPAIR PROTEIN RAD51 HOMOLOG 1","cellular response to alkaloid; cellular response to camptothecin; cellular response to cisplatin; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to hydroxyurea; cellular response to ionizing radiation; chromosome organization involved in meiotic cell cycle; DNA metabolic process; DNA recombinase assembly; DNA recombination; DNA repair; DNA unwinding involved in DNA replication; double-strand break repair via homologous recombination; histone H2A monoubiquitination; interstrand cross-link repair; meiosis I; meiotic cell cycle; mitotic recombination; mitotic recombination-dependent replication fork processing; positive regulation of DNA ligation; protein autoubiquitination; reciprocal meiotic recombination; regulation of DNA damage checkpoint; regulation of double-strand break repair via homologous recombination; regulation of protein phosphorylation; replication fork processing; replication-born double-strand break repair via sister chromatid exchange; response to glucoside; response to organic cyclic compound; response to toxic substance; response to xenobiotic stimulus; response to X-ray; strand invasion; telomere maintenance via recombination; telomere maintenance via telomere lengthening; telomere organization","ATP binding; ATP-dependent activity, acting on DNA; ATP-dependent DNA damage sensor activity; chromatin binding; DNA binding; DNA polymerase binding; DNA strand exchange activity; double-stranded DNA binding; enzyme binding; identical protein binding; nucleic acid binding; nucleotide binding; protein binding; protein C-terminus binding; single-stranded DNA binding; single-stranded DNA helicase activity","chromatin; chromosome; chromosome, telomeric region; condensed chromosome; condensed nuclear chromosome; cytoplasm; cytoskeleton; lateral element; male germ cell nucleus; microtubule organizing center; mitochondrial matrix; mitochondrion; nuclear chromosome; nuclear ubiquitin ligase complex; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body; protein-containing complex; site of double-strand break","DNA damage","RAD51 recombinase","http://www.ncbi.nlm.nih.gov/gene/?term=5888","5888","19361",null,"403568",null,"708579","Q06609","Q08297","A0A8I5YC80","Q8MKI8","A0A5G2R2T3","A0A1D5QVN1","GO:0000785; GO:0005694; GO:0000781; GO:0000793; GO:0000794; GO:0005737; GO:0005856; GO:0000800; GO:0001673; GO:0005815; GO:0005759; GO:0005739; GO:0000228; GO:0000152; GO:0005654; GO:0005634; GO:0048471; GO:0016605; GO:0032991; GO:0035861","GO:0005524; GO:0008094; GO:0140664; GO:0003682; GO:0003677; GO:0070182; GO:0000150; GO:0003690; GO:0019899; GO:0042802; GO:0003676; GO:0000166; GO:0005515; GO:0008022; GO:0003697; GO:0017116","GO:0071312; GO:0072757; GO:0072719; GO:0006974; GO:0071480; GO:0072711; GO:0071479; GO:0070192; GO:0006259; GO:0000730; GO:0006310; GO:0006281; GO:0006268; GO:0000724; GO:0035518; GO:0036297; GO:0007127; GO:0051321; GO:0006312; GO:1990426; GO:0051106; GO:0051865; GO:0007131; GO:2000001; GO:0010569; GO:0001932; GO:0031297; GO:1990414; GO:1904631; GO:0014070; GO:0009636; GO:0009410; GO:0010165; GO:0042148; GO:0000722; GO:0010833; GO:0032200","PTHR22942:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9817|UniProtKB=Q06609"]
["Rad52",null,"RAD52","40","rb",null,8,2,"n/a","n/a","n/a","n/a","# 3075",".CD., .CSP., .DDR., .DREP., .OXS., .SREME.",null,"DNA REPAIR PROTEIN RAD52 HOMOLOG","cellular response to DNA damage stimulus; cellular response to oxidative stress; DNA double-strand break processing involved in repair via single-strand annealing; DNA recombinase assembly; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via single-strand annealing; mitotic recombination; regulation of nucleotide-excision repair","DNA binding; identical protein binding; protein binding; single-stranded DNA binding","nucleoplasm; nucleus; protein-containing complex; protein-DNA complex","DNA damage","RAD52 homolog, DNA repair protein","http://www.ncbi.nlm.nih.gov/gene/?term=5893","5893","19365","297561","477729",null,null,"P43351","P43352","A0A0G2K552","A0A8I3Q232","A0A287BAV5","A0A5K1UD57","GO:0005654; GO:0005634; GO:0032991; GO:0032993","GO:0003677; GO:0042802; GO:0005515; GO:0003697","GO:0006974; GO:0034599; GO:0010792; GO:0000730; GO:0006310; GO:0006281; GO:0006302; GO:0000724; GO:0045002; GO:0006312; GO:2000819","PTHR12132:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9824|UniProtKB=P43351"]
["Rad54B",null,"RAD54B","103","rb",null,7,6,"n/a","n/a","n/a","n/a","# 0965",".CD., .CSP., .DDR., .DREP., .DRR., .OP., .OT.",null,"DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED","cellular response to DNA damage stimulus; chromatin remodeling; determination of adult lifespan; DNA duplex unwinding; DNA repair; double-strand break repair via homologous recombination; mitotic recombination; reciprocal meiotic recombination; response to ionizing radiation; response to xenobiotic stimulus","ATP binding; ATP-dependent chromatin remodeler activity; DNA binding; DNA helicase activity; DNA translocase activity; helicase activity; hydrolase activity; nucleotide binding; protein binding; RNA helicase activity","nucleus",null,"RAD54 homolog B","http://www.ncbi.nlm.nih.gov/gene/?term=25788","25788","623474","102550523",null,null,"699516","Q9Y620","Q6PFE3","D3ZXW3","A0A8I3NZ60",null,"F6VXV3","GO:0005634","GO:0005524; GO:0140658; GO:0003677; GO:0003678; GO:0015616; GO:0004386; GO:0016787; GO:0000166; GO:0005515; GO:0003724","GO:0006974; GO:0006338; GO:0008340; GO:0032508; GO:0006281; GO:0000724; GO:0006312; GO:0007131; GO:0010212; GO:0009410","PTHR45629:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17228|UniProtKB=Q9Y620"]
["Raptor",null,"RPTOR","150","rb",null,2,1.1000000000000001,1.1000000000000001,7,2.1,6.1,"# 1167",".AMPK., .APH., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DDR., .DMTOR., .DRR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TRASR.",null,"REGULATORY-ASSOCIATED PROTEIN OF MTOR","cellular response to amino acid stimulus; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to leucine; cellular response to nutrient levels; cellular response to osmotic stress; cellular response to starvation; negative regulation of autophagy; phosphorylation; positive regulation of cell growth; positive regulation of endothelial cell proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of glycolytic process; positive regulation of lipid biosynthetic process; positive regulation of pentose-phosphate shunt; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of TOR signaling; positive regulation of transcription by RNA polymerase III; regulation of autophagy; regulation of cell growth; regulation of cell size; regulation of phosphorylation; response to xenobiotic stimulus; social behavior; TOR signaling; TORC1 signaling","14-3-3 protein binding; protein binding; protein kinase activator activity; protein kinase binding; protein serine/threonine kinase inhibitor activity; protein-containing complex binding; protein-macromolecule adaptor activity; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding; RNA polymerase III type 3 promoter sequence-specific DNA binding; TFIIIC-class transcription factor complex binding","cytoplasm; cytoplasmic stress granule; cytosol; dendrite; lysosomal membrane; lysosome; neuronal cell body; nucleoplasm; TORC1 complex","mTOR signaling","regulatory associated protein of MTOR complex 1","http://www.ncbi.nlm.nih.gov/gene/?term=57521","57521","74370",null,null,null,null,"Q8N122","A2ACM0","A0A8I6AHQ2","A0A8I3NC05",null,"F6QEI3","GO:0005737; GO:0010494; GO:0005829; GO:0030425; GO:0005765; GO:0005764; GO:0043025; GO:0005654; GO:0031931","GO:0071889; GO:0005515; GO:0030295; GO:0019901; GO:0030291; GO:0044877; GO:0030674; GO:0001002; GO:0001003; GO:0001006; GO:0001156","GO:0071230; GO:0006974; GO:0071456; GO:0071233; GO:0031669; GO:0071470; GO:0009267; GO:0010507; GO:0016310; GO:0030307; GO:0001938; GO:1900087; GO:0045821; GO:0046889; GO:1905857; GO:0033138; GO:0010800; GO:0071902; GO:0032008; GO:0045945; GO:0010506; GO:0001558; GO:0008361; GO:0042325; GO:0009410; GO:0035176; GO:0031929; GO:0038202","PTHR12848:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=30287|UniProtKB=Q8N122"]
["Raptor - phospho","Ser792","RPTOR","150","rb",null,2,2,7,7,7,7,"# 2490",".AMPK., .APH., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DDR., .DMTOR., .DRR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TRASR.",null,"REGULATORY-ASSOCIATED PROTEIN OF MTOR","cellular response to amino acid stimulus; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to leucine; cellular response to nutrient levels; cellular response to osmotic stress; cellular response to starvation; negative regulation of autophagy; phosphorylation; positive regulation of cell growth; positive regulation of endothelial cell proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of glycolytic process; positive regulation of lipid biosynthetic process; positive regulation of pentose-phosphate shunt; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of TOR signaling; positive regulation of transcription by RNA polymerase III; regulation of autophagy; regulation of cell growth; regulation of cell size; regulation of phosphorylation; response to xenobiotic stimulus; social behavior; TOR signaling; TORC1 signaling","14-3-3 protein binding; protein binding; protein kinase activator activity; protein kinase binding; protein serine/threonine kinase inhibitor activity; protein-containing complex binding; protein-macromolecule adaptor activity; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding; RNA polymerase III type 3 promoter sequence-specific DNA binding; TFIIIC-class transcription factor complex binding","cytoplasm; cytoplasmic stress granule; cytosol; dendrite; lysosomal membrane; lysosome; neuronal cell body; nucleoplasm; TORC1 complex","mTOR signaling","regulatory associated protein of MTOR complex 1","http://www.ncbi.nlm.nih.gov/gene/?term=57521","57521","74370",null,null,null,null,"Q8N122","A2ACM0","A0A8I6AHQ2","A0A8I3NC05",null,"F6QEI3","GO:0005737; GO:0010494; GO:0005829; GO:0030425; GO:0005765; GO:0005764; GO:0043025; GO:0005654; GO:0031931","GO:0071889; GO:0005515; GO:0030295; GO:0019901; GO:0030291; GO:0044877; GO:0030674; GO:0001002; GO:0001003; GO:0001006; GO:0001156","GO:0071230; GO:0006974; GO:0071456; GO:0071233; GO:0031669; GO:0071470; GO:0009267; GO:0010507; GO:0016310; GO:0030307; GO:0001938; GO:1900087; GO:0045821; GO:0046889; GO:1905857; GO:0033138; GO:0010800; GO:0071902; GO:0032008; GO:0045945; GO:0010506; GO:0001558; GO:0008361; GO:0042325; GO:0009410; GO:0035176; GO:0031929; GO:0038202","PTHR12848:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=30287|UniProtKB=Q8N122"]
["Ras",null,"KRAS","21","rb",null,1,2,1.1000000000000001,1,1,1,"# 2491",".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .FGFR., .FOXO., .GLI., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .TYR., .VEGFS.","T cell activation; TGF-beta signaling pathway; B cell activation; VEGF signaling pathway; FGF signaling pathway; Ras Pathway; Integrin signalling pathway; PDGF signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; PI3 kinase pathway; p53 pathway feedback loops 2","GTPASE KRAS","actin cytoskeleton organization; cell population proliferation; endocrine signaling; epithelial tube branching involved in lung morphogenesis; forebrain astrocyte development; glial cell proliferation; homeostasis of number of cells within a tissue; MAPK cascade; negative regulation of epithelial cell differentiation; negative regulation of neuron apoptotic process; neuron apoptotic process; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of protein phosphorylation; positive regulation of Rac protein signal transduction; Rac protein signal transduction; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; regulation of synaptic transmission, GABAergic; signal transduction; skeletal muscle cell differentiation; striated muscle cell differentiation; type I pneumocyte differentiation; visual learning","G protein activity; GDP binding; GTP binding; GTPase activity; hydrolase activity; nucleotide binding; protein binding; protein serine/threonine kinase activator activity; protein-containing complex binding; protein-membrane adaptor activity","cytoplasm; cytosol; endomembrane system; endoplasmic reticulum membrane; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; Golgi membrane; membrane; mitochondrial outer membrane; plasma membrane","MAPK signaling","KRAS proto-oncogene, GTPase","http://www.ncbi.nlm.nih.gov/gene/?term=3845","3845","16653",null,null,"100518251",null,"P01116","P32883",null,"A0A8I3PQK0","A0A287B854","F6SFG7","GO:0005737; GO:0005829; GO:0012505; GO:0005789; GO:0031234; GO:0005925; GO:0000139; GO:0016020; GO:0005741; GO:0005886","GO:0003925; GO:0019003; GO:0005525; GO:0003924; GO:0016787; GO:0000166; GO:0005515; GO:0043539; GO:0044877; GO:0043495","GO:0030036; GO:0008283; GO:0038002; GO:0060441; GO:0021897; GO:0014009; GO:0048873; GO:0000165; GO:0030857; GO:0043524; GO:0051402; GO:0008284; GO:0010628; GO:0060252; GO:0001934; GO:0035022; GO:0016601; GO:0007265; GO:0048169; GO:0032228; GO:0007165; GO:0035914; GO:0051146; GO:0060509; GO:0008542","PTHR24070:SF388","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6407|UniProtKB=P01116","P00053; P00052; P00010; P00056; P00021; P04393; P00034; P00047; P00005; P00018; P00031; P00048; P04398"]
["RASGRF1",null,"RASGRF1","145","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1385",".CCP., .CP., .CSP., .MAPK., .OP., .OPA., .RAS., .RTK., .ST.",null,"RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1","activation of GTPase activity; intracellular signal transduction; long-term memory; neuron projection development; positive regulation of GTPase activity; positive regulation of Ras protein signal transduction; Ras protein signal transduction; regulation of neuronal synaptic plasticity; regulation of NMDA receptor activity; regulation of Rac protein signal transduction; regulation of Ras protein signal transduction; regulation of synaptic plasticity; response to endoplasmic reticulum stress; signal transduction; small GTPase mediated signal transduction; type B pancreatic cell proliferation","glutamate receptor binding; guanyl-nucleotide exchange factor activity","cytosol; growth cone; neuron projection; plasma membrane","Neuroscience","Ras protein specific guanine nucleotide releasing factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=5923","5923","19417",null,null,null,null,"Q13972","P27671","A0A0G2JZ23","A0A8P0NFQ2","A0A286ZQN0",null,"GO:0005829; GO:0030426; GO:0043005; GO:0005886","GO:0035254; GO:0005085","GO:0090630; GO:0035556; GO:0007616; GO:0031175; GO:0043547; GO:0046579; GO:0007265; GO:0048168; GO:2000310; GO:0035020; GO:0046578; GO:0048167; GO:0034976; GO:0007165; GO:0007264; GO:0044342","PTHR23113:SF193","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9875|UniProtKB=Q13972"]
["RASSF2",null,"RASSF2","45","gt",null,2,6,6,2,2,2.1,"# 0746",".APO., .CCP., .CCY., .CD., .CSP., .DEV., .EGFR., .HIPPO., .IMUF., .JNK., .NFKB., .OP., .OPA., .RTK., .SREME., .ST.",null,"RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 2","bone remodeling; cell cycle; epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade; homeostasis of number of cells; negative regulation of NIK/NF-kappaB signaling; negative regulation of peptidyl-serine phosphorylation; ossification; positive regulation of apoptotic process; positive regulation of JNK cascade; positive regulation of protein autophosphorylation; positive regulation of protein kinase activity; protein stabilization; regulation of NIK/NF-kappaB signaling; regulation of osteoblast differentiation; regulation of osteoclast differentiation; signal transduction; skeletal system development","protein binding; protein kinase activity","chromosome; chromosome, centromeric region; cytoplasm; cytosol; Golgi apparatus; kinetochore; nucleoplasm; nucleus; plasma membrane; protein-containing complex","Cell cycle control","Ras association domain family member 2","http://www.ncbi.nlm.nih.gov/gene/?term=9770","9770","215653",null,null,null,"718924","P50749","Q8BMS9","A0A8I5Y744","A0A8I3PZB8",null,"H9ZFV4","GO:0005694; GO:0000775; GO:0005737; GO:0005829; GO:0005794; GO:0000776; GO:0005654; GO:0005634; GO:0005886; GO:0032991","GO:0005515; GO:0004672","GO:0046849; GO:0007049; GO:0038168; GO:0048872; GO:1901223; GO:0033137; GO:0001503; GO:0043065; GO:0046330; GO:0031954; GO:0045860; GO:0050821; GO:1901222; GO:0045667; GO:0045670; GO:0007165; GO:0001501","PTHR22738:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9883|UniProtKB=P50749"]
["Rb",null,"RB1","110","ms",null,2,4,6,7,5,5,"BG/MP # 046",".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","p53 pathway feedback loops 2","RETINOBLASTOMA-ASSOCIATED PROTEIN","aortic valve morphogenesis; apoptotic process; cell cycle; cell differentiation; cell division; cell morphogenesis involved in neuron differentiation; cell population proliferation; cellular response to insulin stimulus; cellular response to xenobiotic stimulus; chondrocyte differentiation; chromatin organization; chromatin remodeling; chromosome organization; digestive tract development; enucleate erythrocyte differentiation; epithelial cell proliferation; G1/S transition of mitotic cell cycle; glial cell apoptotic process; glial cell proliferation; hepatocyte apoptotic process; heterochromatin formation; maintenance of mitotic sister chromatid cohesion; myoblast differentiation; negative regulation of apoptotic signaling pathway; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cold-induced thermogenesis; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of mitotic cell cycle; negative regulation of myofibroblast differentiation; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of smoothened signaling pathway; negative regulation of tau-protein kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; neuron apoptotic process; neuron differentiation; neuron maturation; neuron projection development; positive regulation of collagen fibril organization; positive regulation of extracellular matrix organization; positive regulation of macrophage differentiation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; protein localization to chromosome, centromeric region; Ras protein signal transduction; regulation of cell cycle; regulation of cell growth; regulation of centromere complex assembly; regulation of DNA-templated transcription; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription by RNA polymerase II; sister chromatid biorientation; skeletal muscle cell differentiation; smoothened signaling pathway; spermatogenesis; striated muscle cell differentiation; tissue homeostasis; transcription by RNA polymerase II","disordered domain specific binding; DNA binding; DNA-binding transcription factor binding; enzyme binding; identical protein binding; importin-alpha family protein binding; kinase binding; molecular adaptor activity; phosphoprotein binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription corepressor activity; ubiquitin protein ligase binding","chromatin; chromatin lock complex; cyclin/CDK positive transcription elongation factor complex; cytosol; intracellular organelle; nucleoplasm; nucleus; PML body; Rb-E2F complex; spindle; SWI/SNF complex; transcription regulator complex","Cell cycle control / tumor suppressor","RB transcriptional corepressor 1","http://www.ncbi.nlm.nih.gov/gene/?term=5925","5925","19645","24708",null,null,null,"P06400","P13405","P33568","A0A8P0NNS7","A0A287APH4","F7AZM7","GO:0000785; GO:0061793; GO:0008024; GO:0005829; GO:0043229; GO:0005654; GO:0005634; GO:0016605; GO:0035189; GO:0005819; GO:0016514; GO:0005667","GO:0097718; GO:0003677; GO:0140297; GO:0019899; GO:0042802; GO:0061676; GO:0019900; GO:0060090; GO:0051219; GO:0005515; GO:0000977; GO:0061629; GO:0003714; GO:0031625","GO:0003180; GO:0006915; GO:0007049; GO:0030154; GO:0051301; GO:0048667; GO:0008283; GO:0032869; GO:0071466; GO:0002062; GO:0006325; GO:0006338; GO:0051276; GO:0048565; GO:0043353; GO:0050673; GO:0000082; GO:0034349; GO:0014009; GO:0097284; GO:0031507; GO:0034088; GO:0045445; GO:2001234; GO:0045786; GO:0030308; GO:0008285; GO:0120163; GO:0043433; GO:0045892; GO:0050680; GO:2000134; GO:0010629; GO:0060253; GO:1903944; GO:0050728; GO:0045930; GO:1904761; GO:0006469; GO:0071901; GO:0045879; GO:1902948; GO:0000122; GO:0071930; GO:0051402; GO:0030182; GO:0042551; GO:0031175; GO:1904028; GO:1903055; GO:0045651; GO:0045842; GO:0045944; GO:2000679; GO:0071459; GO:0007265; GO:0051726; GO:0001558; GO:0090230; GO:0006355; GO:0043550; GO:0007346; GO:0006357; GO:0031134; GO:0035914; GO:0007224; GO:0007283; GO:0051146; GO:0001894; GO:0006366","PTHR13742:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9884|UniProtKB=P06400","P04398"]
["Rb - phospho","Ser608","RB1","110","rb",null,2,4,8,8,8,8,"# 1271",".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","p53 pathway feedback loops 2","RETINOBLASTOMA-ASSOCIATED PROTEIN","aortic valve morphogenesis; apoptotic process; cell cycle; cell differentiation; cell division; cell morphogenesis involved in neuron differentiation; cell population proliferation; cellular response to insulin stimulus; cellular response to xenobiotic stimulus; chondrocyte differentiation; chromatin organization; chromatin remodeling; chromosome organization; digestive tract development; enucleate erythrocyte differentiation; epithelial cell proliferation; G1/S transition of mitotic cell cycle; glial cell apoptotic process; glial cell proliferation; hepatocyte apoptotic process; heterochromatin formation; maintenance of mitotic sister chromatid cohesion; myoblast differentiation; negative regulation of apoptotic signaling pathway; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cold-induced thermogenesis; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of mitotic cell cycle; negative regulation of myofibroblast differentiation; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of smoothened signaling pathway; negative regulation of tau-protein kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; neuron apoptotic process; neuron differentiation; neuron maturation; neuron projection development; positive regulation of collagen fibril organization; positive regulation of extracellular matrix organization; positive regulation of macrophage differentiation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; protein localization to chromosome, centromeric region; Ras protein signal transduction; regulation of cell cycle; regulation of cell growth; regulation of centromere complex assembly; regulation of DNA-templated transcription; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription by RNA polymerase II; sister chromatid biorientation; skeletal muscle cell differentiation; smoothened signaling pathway; spermatogenesis; striated muscle cell differentiation; tissue homeostasis; transcription by RNA polymerase II","disordered domain specific binding; DNA binding; DNA-binding transcription factor binding; enzyme binding; identical protein binding; importin-alpha family protein binding; kinase binding; molecular adaptor activity; phosphoprotein binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription corepressor activity; ubiquitin protein ligase binding","chromatin; chromatin lock complex; cyclin/CDK positive transcription elongation factor complex; cytosol; intracellular organelle; nucleoplasm; nucleus; PML body; Rb-E2F complex; spindle; SWI/SNF complex; transcription regulator complex","Cell cycle control / tumor suppressor","RB transcriptional corepressor 1","http://www.ncbi.nlm.nih.gov/gene/?term=5925","5925","19645","24708",null,null,null,"P06400","P13405","P33568","A0A8P0NNS7","A0A287APH4","F7AZM7","GO:0000785; GO:0061793; GO:0008024; GO:0005829; GO:0043229; GO:0005654; GO:0005634; GO:0016605; GO:0035189; GO:0005819; GO:0016514; GO:0005667","GO:0097718; GO:0003677; GO:0140297; GO:0019899; GO:0042802; GO:0061676; GO:0019900; GO:0060090; GO:0051219; GO:0005515; GO:0000977; GO:0061629; GO:0003714; GO:0031625","GO:0003180; GO:0006915; GO:0007049; GO:0030154; GO:0051301; GO:0048667; GO:0008283; GO:0032869; GO:0071466; GO:0002062; GO:0006325; GO:0006338; GO:0051276; GO:0048565; GO:0043353; GO:0050673; GO:0000082; GO:0034349; GO:0014009; GO:0097284; GO:0031507; GO:0034088; GO:0045445; GO:2001234; GO:0045786; GO:0030308; GO:0008285; GO:0120163; GO:0043433; GO:0045892; GO:0050680; GO:2000134; GO:0010629; GO:0060253; GO:1903944; GO:0050728; GO:0045930; GO:1904761; GO:0006469; GO:0071901; GO:0045879; GO:1902948; GO:0000122; GO:0071930; GO:0051402; GO:0030182; GO:0042551; GO:0031175; GO:1904028; GO:1903055; GO:0045651; GO:0045842; GO:0045944; GO:2000679; GO:0071459; GO:0007265; GO:0051726; GO:0001558; GO:0090230; GO:0006355; GO:0043550; GO:0007346; GO:0006357; GO:0031134; GO:0035914; GO:0007224; GO:0007283; GO:0051146; GO:0001894; GO:0006366","PTHR13742:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9884|UniProtKB=P06400","P04398"]
["Rb - phospho","Ser780","RB1","110","rb",null,1.1000000000000001,4,"n/a","n/a","n/a","n/a","# 1879",".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","p53 pathway feedback loops 2","RETINOBLASTOMA-ASSOCIATED PROTEIN","aortic valve morphogenesis; apoptotic process; cell cycle; cell differentiation; cell division; cell morphogenesis involved in neuron differentiation; cell population proliferation; cellular response to insulin stimulus; cellular response to xenobiotic stimulus; chondrocyte differentiation; chromatin organization; chromatin remodeling; chromosome organization; digestive tract development; enucleate erythrocyte differentiation; epithelial cell proliferation; G1/S transition of mitotic cell cycle; glial cell apoptotic process; glial cell proliferation; hepatocyte apoptotic process; heterochromatin formation; maintenance of mitotic sister chromatid cohesion; myoblast differentiation; negative regulation of apoptotic signaling pathway; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cold-induced thermogenesis; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of mitotic cell cycle; negative regulation of myofibroblast differentiation; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of smoothened signaling pathway; negative regulation of tau-protein kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; neuron apoptotic process; neuron differentiation; neuron maturation; neuron projection development; positive regulation of collagen fibril organization; positive regulation of extracellular matrix organization; positive regulation of macrophage differentiation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; protein localization to chromosome, centromeric region; Ras protein signal transduction; regulation of cell cycle; regulation of cell growth; regulation of centromere complex assembly; regulation of DNA-templated transcription; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription by RNA polymerase II; sister chromatid biorientation; skeletal muscle cell differentiation; smoothened signaling pathway; spermatogenesis; striated muscle cell differentiation; tissue homeostasis; transcription by RNA polymerase II","disordered domain specific binding; DNA binding; DNA-binding transcription factor binding; enzyme binding; identical protein binding; importin-alpha family protein binding; kinase binding; molecular adaptor activity; phosphoprotein binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription corepressor activity; ubiquitin protein ligase binding","chromatin; chromatin lock complex; cyclin/CDK positive transcription elongation factor complex; cytosol; intracellular organelle; nucleoplasm; nucleus; PML body; Rb-E2F complex; spindle; SWI/SNF complex; transcription regulator complex",null,"RB transcriptional corepressor 1","http://www.ncbi.nlm.nih.gov/gene/?term=5925","5925","19645","24708",null,null,null,"P06400","P13405","P33568","A0A8P0NNS7","A0A287APH4","F7AZM7","GO:0000785; GO:0061793; GO:0008024; GO:0005829; GO:0043229; GO:0005654; GO:0005634; GO:0016605; GO:0035189; GO:0005819; GO:0016514; GO:0005667","GO:0097718; GO:0003677; GO:0140297; GO:0019899; GO:0042802; GO:0061676; GO:0019900; GO:0060090; GO:0051219; GO:0005515; GO:0000977; GO:0061629; GO:0003714; GO:0031625","GO:0003180; GO:0006915; GO:0007049; GO:0030154; GO:0051301; GO:0048667; GO:0008283; GO:0032869; GO:0071466; GO:0002062; GO:0006325; GO:0006338; GO:0051276; GO:0048565; GO:0043353; GO:0050673; GO:0000082; GO:0034349; GO:0014009; GO:0097284; GO:0031507; GO:0034088; GO:0045445; GO:2001234; GO:0045786; GO:0030308; GO:0008285; GO:0120163; GO:0043433; GO:0045892; GO:0050680; GO:2000134; GO:0010629; GO:0060253; GO:1903944; GO:0050728; GO:0045930; GO:1904761; GO:0006469; GO:0071901; GO:0045879; GO:1902948; GO:0000122; GO:0071930; GO:0051402; GO:0030182; GO:0042551; GO:0031175; GO:1904028; GO:1903055; GO:0045651; GO:0045842; GO:0045944; GO:2000679; GO:0071459; GO:0007265; GO:0051726; GO:0001558; GO:0090230; GO:0006355; GO:0043550; GO:0007346; GO:0006357; GO:0031134; GO:0035914; GO:0007224; GO:0007283; GO:0051146; GO:0001894; GO:0006366","PTHR13742:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9884|UniProtKB=P06400","P04398"]
["Rb - phospho","Ser795","RB1","110","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2492",".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","p53 pathway feedback loops 2","RETINOBLASTOMA-ASSOCIATED PROTEIN","aortic valve morphogenesis; apoptotic process; cell cycle; cell differentiation; cell division; cell morphogenesis involved in neuron differentiation; cell population proliferation; cellular response to insulin stimulus; cellular response to xenobiotic stimulus; chondrocyte differentiation; chromatin organization; chromatin remodeling; chromosome organization; digestive tract development; enucleate erythrocyte differentiation; epithelial cell proliferation; G1/S transition of mitotic cell cycle; glial cell apoptotic process; glial cell proliferation; hepatocyte apoptotic process; heterochromatin formation; maintenance of mitotic sister chromatid cohesion; myoblast differentiation; negative regulation of apoptotic signaling pathway; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cold-induced thermogenesis; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of mitotic cell cycle; negative regulation of myofibroblast differentiation; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of smoothened signaling pathway; negative regulation of tau-protein kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; neuron apoptotic process; neuron differentiation; neuron maturation; neuron projection development; positive regulation of collagen fibril organization; positive regulation of extracellular matrix organization; positive regulation of macrophage differentiation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; protein localization to chromosome, centromeric region; Ras protein signal transduction; regulation of cell cycle; regulation of cell growth; regulation of centromere complex assembly; regulation of DNA-templated transcription; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription by RNA polymerase II; sister chromatid biorientation; skeletal muscle cell differentiation; smoothened signaling pathway; spermatogenesis; striated muscle cell differentiation; tissue homeostasis; transcription by RNA polymerase II","disordered domain specific binding; DNA binding; DNA-binding transcription factor binding; enzyme binding; identical protein binding; importin-alpha family protein binding; kinase binding; molecular adaptor activity; phosphoprotein binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription corepressor activity; ubiquitin protein ligase binding","chromatin; chromatin lock complex; cyclin/CDK positive transcription elongation factor complex; cytosol; intracellular organelle; nucleoplasm; nucleus; PML body; Rb-E2F complex; spindle; SWI/SNF complex; transcription regulator complex",null,"RB transcriptional corepressor 1","http://www.ncbi.nlm.nih.gov/gene/?term=5925","5925","19645","24708",null,null,null,"P06400","P13405","P33568","A0A8P0NNS7","A0A287APH4","F7AZM7","GO:0000785; GO:0061793; GO:0008024; GO:0005829; GO:0043229; GO:0005654; GO:0005634; GO:0016605; GO:0035189; GO:0005819; GO:0016514; GO:0005667","GO:0097718; GO:0003677; GO:0140297; GO:0019899; GO:0042802; GO:0061676; GO:0019900; GO:0060090; GO:0051219; GO:0005515; GO:0000977; GO:0061629; GO:0003714; GO:0031625","GO:0003180; GO:0006915; GO:0007049; GO:0030154; GO:0051301; GO:0048667; GO:0008283; GO:0032869; GO:0071466; GO:0002062; GO:0006325; GO:0006338; GO:0051276; GO:0048565; GO:0043353; GO:0050673; GO:0000082; GO:0034349; GO:0014009; GO:0097284; GO:0031507; GO:0034088; GO:0045445; GO:2001234; GO:0045786; GO:0030308; GO:0008285; GO:0120163; GO:0043433; GO:0045892; GO:0050680; GO:2000134; GO:0010629; GO:0060253; GO:1903944; GO:0050728; GO:0045930; GO:1904761; GO:0006469; GO:0071901; GO:0045879; GO:1902948; GO:0000122; GO:0071930; GO:0051402; GO:0030182; GO:0042551; GO:0031175; GO:1904028; GO:1903055; GO:0045651; GO:0045842; GO:0045944; GO:2000679; GO:0071459; GO:0007265; GO:0051726; GO:0001558; GO:0090230; GO:0006355; GO:0043550; GO:0007346; GO:0006357; GO:0031134; GO:0035914; GO:0007224; GO:0007283; GO:0051146; GO:0001894; GO:0006366","PTHR13742:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9884|UniProtKB=P06400","P04398"]
["Rb - phospho","Ser807/Ser811","RB1","110","rb",null,2,4,8,8,8,8,"# 1907",".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","p53 pathway feedback loops 2","RETINOBLASTOMA-ASSOCIATED PROTEIN","aortic valve morphogenesis; apoptotic process; cell cycle; cell differentiation; cell division; cell morphogenesis involved in neuron differentiation; cell population proliferation; cellular response to insulin stimulus; cellular response to xenobiotic stimulus; chondrocyte differentiation; chromatin organization; chromatin remodeling; chromosome organization; digestive tract development; enucleate erythrocyte differentiation; epithelial cell proliferation; G1/S transition of mitotic cell cycle; glial cell apoptotic process; glial cell proliferation; hepatocyte apoptotic process; heterochromatin formation; maintenance of mitotic sister chromatid cohesion; myoblast differentiation; negative regulation of apoptotic signaling pathway; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cold-induced thermogenesis; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of mitotic cell cycle; negative regulation of myofibroblast differentiation; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of smoothened signaling pathway; negative regulation of tau-protein kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; neuron apoptotic process; neuron differentiation; neuron maturation; neuron projection development; positive regulation of collagen fibril organization; positive regulation of extracellular matrix organization; positive regulation of macrophage differentiation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; protein localization to chromosome, centromeric region; Ras protein signal transduction; regulation of cell cycle; regulation of cell growth; regulation of centromere complex assembly; regulation of DNA-templated transcription; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription by RNA polymerase II; sister chromatid biorientation; skeletal muscle cell differentiation; smoothened signaling pathway; spermatogenesis; striated muscle cell differentiation; tissue homeostasis; transcription by RNA polymerase II","disordered domain specific binding; DNA binding; DNA-binding transcription factor binding; enzyme binding; identical protein binding; importin-alpha family protein binding; kinase binding; molecular adaptor activity; phosphoprotein binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription corepressor activity; ubiquitin protein ligase binding","chromatin; chromatin lock complex; cyclin/CDK positive transcription elongation factor complex; cytosol; intracellular organelle; nucleoplasm; nucleus; PML body; Rb-E2F complex; spindle; SWI/SNF complex; transcription regulator complex","Cell cycle control / tumor suppressor","RB transcriptional corepressor 1","http://www.ncbi.nlm.nih.gov/gene/?term=5925","5925","19645","24708",null,null,null,"P06400","P13405","P33568","A0A8P0NNS7","A0A287APH4","F7AZM7","GO:0000785; GO:0061793; GO:0008024; GO:0005829; GO:0043229; GO:0005654; GO:0005634; GO:0016605; GO:0035189; GO:0005819; GO:0016514; GO:0005667","GO:0097718; GO:0003677; GO:0140297; GO:0019899; GO:0042802; GO:0061676; GO:0019900; GO:0060090; GO:0051219; GO:0005515; GO:0000977; GO:0061629; GO:0003714; GO:0031625","GO:0003180; GO:0006915; GO:0007049; GO:0030154; GO:0051301; GO:0048667; GO:0008283; GO:0032869; GO:0071466; GO:0002062; GO:0006325; GO:0006338; GO:0051276; GO:0048565; GO:0043353; GO:0050673; GO:0000082; GO:0034349; GO:0014009; GO:0097284; GO:0031507; GO:0034088; GO:0045445; GO:2001234; GO:0045786; GO:0030308; GO:0008285; GO:0120163; GO:0043433; GO:0045892; GO:0050680; GO:2000134; GO:0010629; GO:0060253; GO:1903944; GO:0050728; GO:0045930; GO:1904761; GO:0006469; GO:0071901; GO:0045879; GO:1902948; GO:0000122; GO:0071930; GO:0051402; GO:0030182; GO:0042551; GO:0031175; GO:1904028; GO:1903055; GO:0045651; GO:0045842; GO:0045944; GO:2000679; GO:0071459; GO:0007265; GO:0051726; GO:0001558; GO:0090230; GO:0006355; GO:0043550; GO:0007346; GO:0006357; GO:0031134; GO:0035914; GO:0007224; GO:0007283; GO:0051146; GO:0001894; GO:0006366","PTHR13742:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9884|UniProtKB=P06400","P04398"]
["RBL1 (p107)",null,"RBL1","115","ms",null,7,4,"n/a","n/a","n/a","n/a","# 1561",".CCP., .CCY., .CD., .CSP., .DEV., .OP., .OT., .P53S., .TGFB., .TRASR.","p53 pathway feedback loops 2","RETINOBLASTOMA-LIKE PROTEIN 1","cell cycle; cell differentiation; chromatin organization; negative regulation of cellular senescence; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of lipid kinase activity; regulation of transcription by RNA polymerase II","promoter-specific chromatin binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding","chromatin; intracellular organelle; nucleoplasm; nucleus; transcription regulator complex","Chromatin regulation / epigenetics","RB transcriptional corepressor like 1","http://www.ncbi.nlm.nih.gov/gene/?term=5933","5933","19650",null,"477221",null,null,"P28749","Q64701","A0A573VVF2","A0A8I3Q0G8","A0A286ZJW1","F7CLV0","GO:0000785; GO:0043229; GO:0005654; GO:0005634; GO:0005667","GO:1990841; GO:0005515; GO:0000977","GO:0007049; GO:0030154; GO:0006325; GO:2000773; GO:2000134; GO:0010629; GO:0000122; GO:0051726; GO:0043550; GO:0006357","PTHR13742:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9893|UniProtKB=P28749","P04398"]
["RBL1 (p107) - phospho","Thr369","RBL1","120","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1386",".CCP., .CCY., .CD., .CSP., .DEV., .OP., .OT., .P53S., .TGFB., .TRASR.","p53 pathway feedback loops 2","RETINOBLASTOMA-LIKE PROTEIN 1","cell cycle; cell differentiation; chromatin organization; negative regulation of cellular senescence; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; regulation of cell cycle; regulation of lipid kinase activity; regulation of transcription by RNA polymerase II","promoter-specific chromatin binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding","chromatin; intracellular organelle; nucleoplasm; nucleus; transcription regulator complex","Chromatin regulation / epigenetics","RB transcriptional corepressor like 1","http://www.ncbi.nlm.nih.gov/gene/?term=5933","5933","19650",null,"477221",null,null,"P28749","Q64701","A0A573VVF2","A0A8I3Q0G8","A0A286ZJW1","F7CLV0","GO:0000785; GO:0043229; GO:0005654; GO:0005634; GO:0005667","GO:1990841; GO:0005515; GO:0000977","GO:0007049; GO:0030154; GO:0006325; GO:2000773; GO:2000134; GO:0010629; GO:0000122; GO:0051726; GO:0043550; GO:0006357","PTHR13742:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9893|UniProtKB=P28749","P04398"]
["RBL2 (p130)",null,"RBL2","128","rb",null,2,4,8,8,8,8,"# 1403",".CCP., .CCY., .CSP., .FOXO., .OP., .OPA., .OT., .PI3K., .RTK., .TRASR.",null,"RETINOBLASTOMA-LIKE PROTEIN 2","cell cycle; cell differentiation; chromatin organization; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; regulation of cell cycle; regulation of lipid kinase activity; regulation of transcription by RNA polymerase II","DNA binding; promoter-specific chromatin binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding","chromatin; chromosome; cytosol; extracellular exosome; intracellular organelle; nucleolus; nucleoplasm; nucleus; transcription regulator complex","Cell cycle control","RB transcriptional corepressor like 2","http://www.ncbi.nlm.nih.gov/gene/?term=5934","5934","19651",null,"478127",null,"696992","Q08999","Q64700","A0A8I6AAZ8","A0A8I3N5E1",null,"A0A1D5QDE7","GO:0000785; GO:0005694; GO:0005829; GO:0070062; GO:0043229; GO:0005730; GO:0005654; GO:0005634; GO:0005667","GO:0003677; GO:1990841; GO:0005515; GO:0000977","GO:0007049; GO:0030154; GO:0006325; GO:2000134; GO:0010629; GO:0051726; GO:0043550; GO:0006357","PTHR13742:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9894|UniProtKB=Q08999"]
["RBL2 (p130) - phospho","Ser952","RBL2","128","rb",null,2,4,8,7,2.1,2,"# 1391",".CCP., .CCY., .CSP., .FOXO., .OP., .OPA., .OT., .PI3K., .RTK., .TRASR.",null,"RETINOBLASTOMA-LIKE PROTEIN 2","cell cycle; cell differentiation; chromatin organization; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; regulation of cell cycle; regulation of lipid kinase activity; regulation of transcription by RNA polymerase II","DNA binding; promoter-specific chromatin binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding","chromatin; chromosome; cytosol; extracellular exosome; intracellular organelle; nucleolus; nucleoplasm; nucleus; transcription regulator complex","Cell cycle control","RB transcriptional corepressor like 2","http://www.ncbi.nlm.nih.gov/gene/?term=5934","5934","19651",null,"478127",null,"696992","Q08999","Q64700","A0A8I6AAZ8","A0A8I3N5E1",null,"A0A1D5QDE7","GO:0000785; GO:0005694; GO:0005829; GO:0070062; GO:0043229; GO:0005730; GO:0005654; GO:0005634; GO:0005667","GO:0003677; GO:1990841; GO:0005515; GO:0000977","GO:0007049; GO:0030154; GO:0006325; GO:2000134; GO:0010629; GO:0051726; GO:0043550; GO:0006357","PTHR13742:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9894|UniProtKB=Q08999"]
["RBPSUH",null,"RBPJ","61","rb",null,1,1,1,5,1,2,"# 1427",".ALZ., .ANG., .BCR., .BMP., .CANCER., .CCP., .CP., .CSP., .DEV., .DI., .ErbB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .NOTCH., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TCD., .TMAT., .TRASR.","Notch signaling pathway; Alzheimer disease-presenilin pathway; Angiogenesis","RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS","angiogenesis; aortic valve development; arterial endothelial cell fate commitment; artery morphogenesis; atrioventricular canal development; auditory receptor cell fate commitment; B cell differentiation; blood vessel endothelial cell fate specification; blood vessel lumenization; blood vessel remodeling; cardiac left ventricle morphogenesis; cardiac muscle cell myoblast differentiation; cell differentiation; cell fate commitment; cell population proliferation; club cell differentiation; defense response to bacterium; dorsal aorta morphogenesis; endocardium development; endocardium morphogenesis; epidermal cell fate specification; epithelial cell proliferation; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; hair follicle maturation; heart development; hemopoiesis; humoral immune response; inflammatory response to antigenic stimulus; keratinocyte differentiation; labyrinthine layer blood vessel development; myeloid dendritic cell differentiation; negative regulation of cell differentiation; negative regulation of cold-induced thermogenesis; negative regulation of DNA-templated transcription; negative regulation of ossification; negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; neuron differentiation; Notch signaling involved in heart development; Notch signaling pathway; outflow tract morphogenesis; pituitary gland development; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation involved in heart morphogenesis; positive regulation of ephrin receptor signaling pathway; positive regulation of epithelial cell proliferation; positive regulation of ERBB signaling pathway; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription of Notch receptor target; pulmonary valve development; regulation of DNA-templated transcription; regulation of epithelial cell proliferation; regulation of gene expression; regulation of reproductive process; regulation of timing of cell differentiation; regulation of transcription by RNA polymerase II; sebaceous gland development; secondary heart field specification; somatic stem cell population maintenance; somitogenesis; stem cell proliferation; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis","chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; protein binding; protein N-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding","chromatin; cytoplasm; MAML1-RBP-Jkappa- ICN1 complex; nucleolus; nucleoplasm; nucleus; transcription regulator complex; transcription repressor complex","Development","recombination signal binding protein for immunoglobulin kappa J region","http://www.ncbi.nlm.nih.gov/gene/?term=3516","3516","19664",null,null,"100518262","694601","Q06330","P31266","F1LNW1","A0A8I3MR34","A0A287A324","A0A1D5R3Z3","GO:0000785; GO:0005737; GO:0002193; GO:0005730; GO:0005654; GO:0005634; GO:0005667; GO:0017053","GO:0003682; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0005515; GO:0047485; GO:0000978; GO:0061629; GO:0043565","GO:0001525; GO:0003176; GO:0060844; GO:0048844; GO:0036302; GO:0009912; GO:0030183; GO:0097101; GO:0072554; GO:0001974; GO:0003214; GO:0060379; GO:0030154; GO:0045165; GO:0008283; GO:0060486; GO:0042742; GO:0035912; GO:0003157; GO:0003160; GO:0009957; GO:0050673; GO:0001837; GO:0003198; GO:0048820; GO:0007507; GO:0030097; GO:0006959; GO:0002437; GO:0030216; GO:0060716; GO:0043011; GO:0045596; GO:0120163; GO:0045892; GO:0030279; GO:2000647; GO:0000122; GO:0030182; GO:0061314; GO:0007219; GO:0003151; GO:0021983; GO:0030513; GO:1901297; GO:0060045; GO:2000138; GO:1901189; GO:0050679; GO:1901186; GO:0010628; GO:0045944; GO:0061419; GO:0007221; GO:0003177; GO:0006355; GO:0050678; GO:0010468; GO:2000241; GO:0048505; GO:0006357; GO:0048733; GO:0003139; GO:0035019; GO:0001756; GO:0072089; GO:0060412; GO:0003222","PTHR10665:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5724|UniProtKB=Q06330","P00045; P00004; P00005"]
["RecQL1",null,"RECQL","75","rb",null,2,7,7,7,6,6,"# 0897",".CD., .CSP., .DDR., .DREP.",null,"ATP-DEPENDENT DNA HELICASE Q1","DNA duplex unwinding; DNA geometric change; DNA recombination; DNA repair; DNA unwinding involved in DNA replication; double-strand break repair via homologous recombination","3'-5' DNA helicase activity; ATP binding; ATP hydrolysis activity; DNA binding; DNA helicase activity; DNA/DNA annealing activity; four-way junction helicase activity; helicase activity; hydrolase activity; nucleic acid binding; nucleotide binding; protein binding","chromosome; cytoplasm; membrane; nucleoplasm; nucleus",null,"RecQ like helicase","http://www.ncbi.nlm.nih.gov/gene/?term=5965","5965","19691","312824","486641",null,"705871","P46063","Q9Z129","Q6AYJ1","A0A8I3NQI4","A0A287BGJ9","A0A5F8A131","GO:0005694; GO:0005737; GO:0016020; GO:0005654; GO:0005634","GO:0043138; GO:0005524; GO:0016887; GO:0003677; GO:0003678; GO:1990814; GO:0009378; GO:0004386; GO:0016787; GO:0003676; GO:0000166; GO:0005515","GO:0032508; GO:0032392; GO:0006310; GO:0006281; GO:0006268; GO:0000724","PTHR13710:SF72","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9948|UniProtKB=P46063"]
["REDD1",null,"DDIT4","28","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2384",".APH., .APO., .CD., .CSP., .CUR., .D300., .DMTOR., .HIF., .IMUR., .MIG., .MTOR., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .RTK., .SREME., .ST., .VIR.",null,"DNA DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN","apoptotic process; brain development; cellular response to dexamethasone stimulus; defense response to virus; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of glycolytic process; negative regulation of intracellular signal transduction; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-threonine phosphorylation; negative regulation of signal transduction; negative regulation of TOR signaling; neuron differentiation; neuron migration; neurotrophin TRK receptor signaling pathway; positive regulation of neuron death; protein-containing complex disassembly; reactive oxygen species metabolic process; regulation of TOR signaling; response to hypoxia","14-3-3 protein binding; protein binding","cytoplasm; cytosol; mitochondrion",null,"DNA damage inducible transcript 4","http://www.ncbi.nlm.nih.gov/gene/?term=54541","54541","74747",null,"489038",null,null,"Q9NX09","Q9D3F7","G3V620","A0A8I3N0L7",null,null,"GO:0005737; GO:0005829; GO:0005739","GO:0071889; GO:0005515","GO:0006915; GO:0007420; GO:0071549; GO:0051607; GO:0042771; GO:0045820; GO:1902532; GO:0033137; GO:0010801; GO:0009968; GO:0032007; GO:0030182; GO:0001764; GO:0048011; GO:1901216; GO:0032984; GO:0072593; GO:0032006; GO:0001666","PTHR12478:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24944|UniProtKB=Q9NX09"]
["RelB",null,"RELB","70","rb",null,2,6,7,1,1,8,"# 0672",".APO., .CD., .CSP., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .NFKB., .OP., .OT., .RTK., .TRASR.","Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR RELB","antigen processing and presentation; cellular response to osmotic stress; circadian regulation of gene expression; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; lymphocyte differentiation; myeloid dendritic cell differentiation; negative regulation of DNA-templated transcription; negative regulation of interferon-beta production; negative regulation of macromolecule metabolic process; NIK/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to cytokine; rhythmic process; T-helper 1 cell differentiation; T-helper 1 type immune response","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; microtubule organizing center; NF-kappaB complex; nucleoplasm; nucleus; protein-containing complex; synapse; transcription repressor complex",null,"RELB proto-oncogene, NF-kB subunit","http://www.ncbi.nlm.nih.gov/gene/?term=5971","5971","19698","100360982",null,null,null,"Q01201","Q04863","D3Z9V1","A0A8I3MRI7",null,"F7BV28","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005815; GO:0071159; GO:0005654; GO:0005634; GO:0032991; GO:0045202; GO:0017053","GO:0003677; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0019901; GO:0000978","GO:0019882; GO:0071470; GO:0032922; GO:0007249; GO:0006954; GO:0045087; GO:0030098; GO:0043011; GO:0045892; GO:0032688; GO:0010605; GO:0038061; GO:0045944; GO:0006355; GO:0006357; GO:0034097; GO:0048511; GO:0045063; GO:0042088","PTHR24169:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9956|UniProtKB=Q01201","P00031; P00006"]
["RelB - phospho","Ser552","RELB","70","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1280",".APO., .CD., .CSP., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .NFKB., .OP., .OT., .RTK., .TRASR.","Inflammation mediated by chemokine and cytokine signaling pathway; Apoptosis signaling pathway","TRANSCRIPTION FACTOR RELB","antigen processing and presentation; cellular response to osmotic stress; circadian regulation of gene expression; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; lymphocyte differentiation; myeloid dendritic cell differentiation; negative regulation of DNA-templated transcription; negative regulation of interferon-beta production; negative regulation of macromolecule metabolic process; NIK/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to cytokine; rhythmic process; T-helper 1 cell differentiation; T-helper 1 type immune response","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding","centrosome; chromatin; cytoplasm; cytoskeleton; cytosol; microtubule organizing center; NF-kappaB complex; nucleoplasm; nucleus; protein-containing complex; synapse; transcription repressor complex","NFkB signaling","RELB proto-oncogene, NF-kB subunit","http://www.ncbi.nlm.nih.gov/gene/?term=5971","5971","19698","100360982",null,null,null,"Q01201","Q04863","D3Z9V1","A0A8I3MRI7",null,"F7BV28","GO:0005813; GO:0000785; GO:0005737; GO:0005856; GO:0005829; GO:0005815; GO:0071159; GO:0005654; GO:0005634; GO:0032991; GO:0045202; GO:0017053","GO:0003677; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0019901; GO:0000978","GO:0019882; GO:0071470; GO:0032922; GO:0007249; GO:0006954; GO:0045087; GO:0030098; GO:0043011; GO:0045892; GO:0032688; GO:0010605; GO:0038061; GO:0045944; GO:0006355; GO:0006357; GO:0034097; GO:0048511; GO:0045063; GO:0042088","PTHR24169:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9956|UniProtKB=Q01201","P00031; P00006"]
["RGS1",null,"RGS1","20","rb",null,7,7,"n/a","n/a","n/a","n/a","# 0627",".CSP., .GPCR., .GPROT., .IMU., .IMUF., .IMUR., .INFM., .OP., .OPA., .ST.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; Inflammation mediated by chemokine and cytokine signaling pathway","REGULATOR OF G-PROTEIN SIGNALING 1","adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; immune response; leukotriene signaling pathway; negative regulation of signal transduction; positive regulation of GTPase activity; response to bacterium; signal transduction","calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity; GTPase activity","cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; membrane; plasma membrane",null,"regulator of G protein signaling 1","http://www.ncbi.nlm.nih.gov/gene/?term=5996","5996","50778","54289","488585",null,"712754","Q08116","Q9JL25","P97844","A0A8I3PM57",null,"A0A5K1U7A0","GO:0005737; GO:0005829; GO:0031234; GO:0016020; GO:0005886","GO:0005516; GO:0001965; GO:0005096; GO:0003924","GO:0007193; GO:0007186; GO:0006955; GO:0061737; GO:0009968; GO:0043547; GO:0009617; GO:0007165","PTHR10845:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9991|UniProtKB=Q08116","P00027; P00026; P00031"]
["RGS2",null,"RGS2","24","rb",null,7,2,"n/a","n/a","n/a","n/a","# 2259",".CCKR., .CCP., .CCY., .CP., .CSP., .DRR., .GPCR., .GPROT., .MAPK., .OP., .OPA., .OT., .RTK., .ST., .TRASR.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; CCKR signaling map; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway","REGULATOR OF G-PROTEIN SIGNALING 2","brain development; brown fat cell differentiation; cell cycle; G protein-coupled receptor signaling pathway; maternal process involved in female pregnancy; negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process; negative regulation of cardiac muscle hypertrophy; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of glycine import across plasma membrane; negative regulation of MAP kinase activity; negative regulation of phospholipase activity; negative regulation of signal transduction; negative regulation of translation; ovulation; positive regulation of cardiac muscle contraction; positive regulation of neuron projection development; regulation of G protein-coupled receptor signaling pathway; regulation of translation; relaxation of cardiac muscle; relaxation of vascular associated smooth muscle; response to amphetamine; response to ethanol; spermatogenesis","adenylate cyclase inhibitor activity; beta-tubulin binding; calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity; GTPase activity; protein binding","cytoplasm; cytoplasmic side of plasma membrane; cytosol; membrane; mitochondrion; neuron projection; nucleolus; nucleus; plasma membrane",null,"regulator of G protein signaling 2","http://www.ncbi.nlm.nih.gov/gene/?term=5997","5997","19735","84583",null,null,null,"P41220","O08849","Q9JHX0","A0A8I3PVE7",null,null,"GO:0005737; GO:0009898; GO:0005829; GO:0016020; GO:0005739; GO:0043005; GO:0005730; GO:0005634; GO:0005886","GO:0010855; GO:0048487; GO:0005516; GO:0001965; GO:0005096; GO:0003924; GO:0005515","GO:0007420; GO:0050873; GO:0007049; GO:0007186; GO:0060135; GO:0140194; GO:0010614; GO:0061052; GO:0045744; GO:1900924; GO:0043407; GO:0010519; GO:0009968; GO:0017148; GO:0030728; GO:0060452; GO:0010976; GO:0008277; GO:0006417; GO:0055119; GO:0060087; GO:0001975; GO:0045471; GO:0007283","PTHR10845:SF43","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9998|UniProtKB=P41220","P00027; P06959; P00026"]
["RGS5",null,"RGS5","25","gt",null,1,2,2,6,2.1,8,"# 0628",".CSP., .GPCR., .GPROT., .OPA., .ST.","Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway","REGULATOR OF G-PROTEIN SIGNALING 5","G protein-coupled receptor signaling pathway; negative regulation of signal transduction; regulation of G protein-coupled receptor signaling pathway","GTPase activator activity; GTPase activity; protein binding","cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; plasma membrane",null,"regulator of G protein signaling 5","http://www.ncbi.nlm.nih.gov/gene/?term=8490","8490","19737","54294",null,null,null,"O15539","O08850","P49800",null,null,"A0A5F7ZVQ9","GO:0005737; GO:0005829; GO:0043231; GO:0016020; GO:0005886","GO:0005096; GO:0003924; GO:0005515","GO:0007186; GO:0009968; GO:0008277","PTHR10845:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10001|UniProtKB=O15539","P00027; P00026"]
["RHEB",null,"RHEB","20","rb",null,1,1,1,1,1,1,"# 1390",".AMPK., .APH., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST.","CCKR signaling map; p53 pathway by glucose deprivation","GTP-BINDING PROTEIN RHEB","negative regulation of cold-induced thermogenesis; oligodendrocyte differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of TOR signaling; regulation of cell cycle; regulation of macroautophagy; regulation of TOR signaling; regulation of type B pancreatic cell development; signal transduction; small GTPase mediated signal transduction","GDP binding; GTP binding; GTPase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase binding","cytoplasm; cytosol; endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular exosome; Golgi apparatus; Golgi membrane; lysosomal membrane; membrane; plasma membrane; postsynaptic density; spliceosomal complex; synapse","Cell membrane","Ras homolog, mTORC1 binding","http://www.ncbi.nlm.nih.gov/gene/?term=6009","6009","19744","26954","475545",null,null,"Q15382","Q921J2","Q62639","A0A8I3N749","A0A287A6X6",null,"GO:0005737; GO:0005829; GO:0012505; GO:0005783; GO:0005789; GO:0070062; GO:0005794; GO:0000139; GO:0005765; GO:0016020; GO:0005886; GO:0014069; GO:0005681; GO:0045202","GO:0019003; GO:0005525; GO:0003924; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0019901","GO:0120163; GO:0048709; GO:0048714; GO:0032008; GO:0051726; GO:0016241; GO:0032006; GO:2000074; GO:0007165; GO:0007264","PTHR24070:SF264","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10011|UniProtKB=Q15382","P06959; P04397"]
["Rictor",null,"RICTOR","200","rb",null,1,2.1,8,8,4,4,"# 2494",".APO., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DMTOR., .IMFR., .IMUR., .MTOR., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.",null,"RAPAMYCIN-INSENSITIVE COMPANION OF MTOR","actin cytoskeleton reorganization; cell communication; cellular response to nutrient levels; cellular response to stimulus; cytoskeleton organization; embryo development ending in birth or egg hatching; negative regulation of apoptotic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell growth; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of TOR signaling; regulation of actin cytoskeleton organization; regulation of establishment of cell polarity; regulation of gene expression; regulation of GTPase activity; regulation of inflammatory response; regulation of peptidyl-serine phosphorylation; regulation of protein kinase B signaling; regulation of protein phosphorylation; TOR signaling; TORC2 signaling","molecular adaptor activity; protein binding; protein kinase binding; protein serine/threonine kinase activator activity; ribosome binding","cytosol; TORC2 complex","Translational control","RPTOR independent companion of MTOR complex 2","http://www.ncbi.nlm.nih.gov/gene/?term=253260","253260","78757",null,null,null,null,"Q6R327","Q6QI06","A0A8I5ZNG4","A0A8I3MHW6","A0A286ZSJ0","A0A5F7Z9A6","GO:0005829; GO:0031932","GO:0060090; GO:0005515; GO:0019901; GO:0043539; GO:0043022","GO:0031532; GO:0007154; GO:0031669; GO:0051716; GO:0007010; GO:0009792; GO:0043066; GO:0018105; GO:0016310; GO:0030838; GO:0030307; GO:0050731; GO:0051897; GO:0032008; GO:0032956; GO:2000114; GO:0010468; GO:0043087; GO:0050727; GO:0033135; GO:0051896; GO:0001932; GO:0031929; GO:0038203","PTHR13298:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=28611|UniProtKB=Q6R327"]
["Rictor - phospho","Thr1135","RICTOR","200","rb",null,4,2.1,4,4,4,4,"# 1215",".APO., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DMTOR., .IMFR., .IMUR., .MTOR., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.",null,"RAPAMYCIN-INSENSITIVE COMPANION OF MTOR","actin cytoskeleton reorganization; cell communication; cellular response to nutrient levels; cellular response to stimulus; cytoskeleton organization; embryo development ending in birth or egg hatching; negative regulation of apoptotic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell growth; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of TOR signaling; regulation of actin cytoskeleton organization; regulation of establishment of cell polarity; regulation of gene expression; regulation of GTPase activity; regulation of inflammatory response; regulation of peptidyl-serine phosphorylation; regulation of protein kinase B signaling; regulation of protein phosphorylation; TOR signaling; TORC2 signaling","molecular adaptor activity; protein binding; protein kinase binding; protein serine/threonine kinase activator activity; ribosome binding","cytosol; TORC2 complex","Translational control","RPTOR independent companion of MTOR complex 2","http://www.ncbi.nlm.nih.gov/gene/?term=253260","253260","78757",null,null,null,null,"Q6R327","Q6QI06","A0A8I5ZNG4","A0A8I3MHW6","A0A286ZSJ0","A0A5F7Z9A6","GO:0005829; GO:0031932","GO:0060090; GO:0005515; GO:0019901; GO:0043539; GO:0043022","GO:0031532; GO:0007154; GO:0031669; GO:0051716; GO:0007010; GO:0009792; GO:0043066; GO:0018105; GO:0016310; GO:0030838; GO:0030307; GO:0050731; GO:0051897; GO:0032008; GO:0032956; GO:2000114; GO:0010468; GO:0043087; GO:0050727; GO:0033135; GO:0051896; GO:0001932; GO:0031929; GO:0038203","PTHR13298:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=28611|UniProtKB=Q6R327"]
["RING1A",null,"RING1","58","rb",null,1,1,2,6,1.1000000000000001,8,"# 1455",".OP., .OT., .TRASR., .UBI.",null,"E3 UBIQUITIN-PROTEIN LIGASE RING1","anterior/posterior pattern specification; camera-type eye morphogenesis; chromatin organization; chromatin remodeling; histone H2A monoubiquitination; histone ubiquitination; negative regulation of DNA-templated transcription; protein ubiquitination","chromatin binding; metal ion binding; protein binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activator activity","cytosol; nuclear body; nuclear speck; nucleoplasm; nucleus; PcG protein complex; PRC1 complex; sex chromatin; ubiquitin ligase complex","Chromatin regulation / epigenetics","ring finger protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=6015","6015","19763",null,"607905",null,"718137","Q06587","O35730","A0A0G2K5V5","Q5TJF3","A0A287AJ58","F7H862","GO:0005829; GO:0016604; GO:0016607; GO:0005654; GO:0005634; GO:0031519; GO:0035102; GO:0001739; GO:0000151","GO:0003682; GO:0046872; GO:0005515; GO:0016740; GO:0061630; GO:0097027","GO:0009952; GO:0048593; GO:0006325; GO:0006338; GO:0035518; GO:0016574; GO:0045892; GO:0016567","PTHR46076:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10018|UniProtKB=Q06587"]
["RING1B",null,"RNF2","41","rb",null,1.1000000000000001,4,8,8,8,8,"# 1456",".CCP., .CCY., .OP., .OT., .TRASR., .UBI.",null,"E3 UBIQUITIN-PROTEIN LIGASE RING2","anterior/posterior axis specification; chromatin remodeling; gastrulation with mouth forming second; gene expression; germ cell development; histone H2A monoubiquitination; histone H2A-K119 monoubiquitination; histone ubiquitination; mitotic cell cycle; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; protein ubiquitination","chromatin binding; metal ion binding; protein binding; RING-like zinc finger domain binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding","chromosome; cytoplasm; euchromatin; heterochromatin; MLL1 complex; nuclear body; nucleoplasm; nucleus; PcG protein complex; PRC1 complex; sex chromatin; ubiquitin ligase complex","Chromatin regulation / epigenetics","ring finger protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=6045","6045","19821","304850",null,null,null,"Q99496","Q9CQJ4","Q4KLY4","A0A8I3MMY7","A0A286ZJ39","F7B4A1","GO:0005694; GO:0005737; GO:0000791; GO:0000792; GO:0071339; GO:0016604; GO:0005654; GO:0005634; GO:0031519; GO:0035102; GO:0001739; GO:0000151","GO:0003682; GO:0046872; GO:0005515; GO:0071535; GO:0016740; GO:0061630; GO:0004842; GO:0008270","GO:0009948; GO:0006338; GO:0001702; GO:0010467; GO:0007281; GO:0035518; GO:0036353; GO:0016574; GO:0000278; GO:0043433; GO:0000122; GO:0016567","PTHR46076:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10061|UniProtKB=Q99496"]
["RIP",null,"RIPK1","78","rb",null,1,2,"n/a","n/a","n/a","n/a","# 2423",".APO., .CD., .CSP., .IMFR., .IMUF., .IMUR., .INFM., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TNF., .TOLL., .TRASR.","Apoptosis signaling pathway","RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1","amyloid fibril formation; apoptotic process; cell death; cellular response to cytokine stimulus; cellular response to growth factor stimulus; cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; extrinsic apoptotic signaling pathway; inflammatory response; MAPK cascade; necroptotic process; necroptotic signaling pathway; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of necroptotic process; peptidyl-serine autophosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of cell death; positive regulation of defense response; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of gene expression; positive regulation of hydrogen peroxide-induced cell death; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of interleukin-6-mediated signaling pathway; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of macrophage differentiation; positive regulation of MAPK cascade; positive regulation of molecular function; positive regulation of necroptotic process; positive regulation of necrotic cell death; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphorylation; positive regulation of programmed cell death; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; positive regulation of response to external stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of tumor necrosis factor-mediated signaling pathway; programmed cell death; programmed necrotic cell death; protein autophosphorylation; protein catabolic process; protein phosphorylation; regulation of ATP:ADP antiporter activity; regulation of cellular biosynthetic process; regulation of gene expression; regulation of macromolecule biosynthetic process; regulation of reactive oxygen species metabolic process; response to tumor necrosis factor; ripoptosome assembly; ripoptosome assembly involved in necroptotic process; signal transduction; T cell apoptotic process; tumor necrosis factor-mediated signaling pathway","ATP binding; death domain binding; death receptor binding; identical protein binding; JUN kinase kinase kinase activity; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transferase activity; ubiquitin protein ligase binding","cytoplasm; cytosol; death-inducing signaling complex; endosome membrane; membrane; membrane raft; mitochondrion; plasma membrane; protein-containing complex; receptor complex; ripoptosome",null,"receptor interacting serine/threonine kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=8737","8737","19766","306886",null,"100524751",null,"Q13546","Q60855","D3ZYL0","A0A8P0SEA0","A0A287B558","F6THC2","GO:0005737; GO:0005829; GO:0031264; GO:0010008; GO:0016020; GO:0045121; GO:0005739; GO:0005886; GO:0032991; GO:0043235; GO:0097342","GO:0005524; GO:0070513; GO:0005123; GO:0042802; GO:0004706; GO:0016301; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0016740; GO:0031625","GO:1990000; GO:0006915; GO:0008219; GO:0071345; GO:0071363; GO:0070301; GO:0071356; GO:0097191; GO:0006954; GO:0000165; GO:0070266; GO:0097527; GO:0043066; GO:2001237; GO:2001240; GO:0043124; GO:0060546; GO:0036289; GO:0016310; GO:0043065; GO:0010942; GO:0031349; GO:2001238; GO:0010628; GO:1905206; GO:0043123; GO:0050729; GO:0070105; GO:0032757; GO:0046330; GO:0045651; GO:0043410; GO:0044093; GO:0060545; GO:0010940; GO:0051092; GO:0042327; GO:0043068; GO:0001934; GO:2000379; GO:0032103; GO:0045944; GO:0032760; GO:1903265; GO:0012501; GO:0097300; GO:0046777; GO:0030163; GO:0006468; GO:0070926; GO:0031326; GO:0010468; GO:0010556; GO:2000377; GO:0034612; GO:0097343; GO:1901026; GO:0007165; GO:0070231; GO:0033209","PTHR44329:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10019|UniProtKB=Q13546","P00006"]
["RIP - phospho","Ser116","RIPK1","82-78","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2424",".APO., .CD., .CSP., .IMFR., .IMUF., .IMUR., .INFM., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TNF., .TOLL., .TRASR.","Apoptosis signaling pathway","RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1","amyloid fibril formation; apoptotic process; cell death; cellular response to cytokine stimulus; cellular response to growth factor stimulus; cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; extrinsic apoptotic signaling pathway; inflammatory response; MAPK cascade; necroptotic process; necroptotic signaling pathway; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of necroptotic process; peptidyl-serine autophosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of cell death; positive regulation of defense response; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of gene expression; positive regulation of hydrogen peroxide-induced cell death; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of interleukin-6-mediated signaling pathway; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of macrophage differentiation; positive regulation of MAPK cascade; positive regulation of molecular function; positive regulation of necroptotic process; positive regulation of necrotic cell death; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphorylation; positive regulation of programmed cell death; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; positive regulation of response to external stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of tumor necrosis factor-mediated signaling pathway; programmed cell death; programmed necrotic cell death; protein autophosphorylation; protein catabolic process; protein phosphorylation; regulation of ATP:ADP antiporter activity; regulation of cellular biosynthetic process; regulation of gene expression; regulation of macromolecule biosynthetic process; regulation of reactive oxygen species metabolic process; response to tumor necrosis factor; ripoptosome assembly; ripoptosome assembly involved in necroptotic process; signal transduction; T cell apoptotic process; tumor necrosis factor-mediated signaling pathway","ATP binding; death domain binding; death receptor binding; identical protein binding; JUN kinase kinase kinase activity; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transferase activity; ubiquitin protein ligase binding","cytoplasm; cytosol; death-inducing signaling complex; endosome membrane; membrane; membrane raft; mitochondrion; plasma membrane; protein-containing complex; receptor complex; ripoptosome",null,"receptor interacting serine/threonine kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=8737","8737","19766","306886",null,"100524751",null,"Q13546","Q60855","D3ZYL0","A0A8P0SEA0","A0A287B558","F6THC2","GO:0005737; GO:0005829; GO:0031264; GO:0010008; GO:0016020; GO:0045121; GO:0005739; GO:0005886; GO:0032991; GO:0043235; GO:0097342","GO:0005524; GO:0070513; GO:0005123; GO:0042802; GO:0004706; GO:0016301; GO:0000166; GO:0005515; GO:0042803; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0016740; GO:0031625","GO:1990000; GO:0006915; GO:0008219; GO:0071345; GO:0071363; GO:0070301; GO:0071356; GO:0097191; GO:0006954; GO:0000165; GO:0070266; GO:0097527; GO:0043066; GO:2001237; GO:2001240; GO:0043124; GO:0060546; GO:0036289; GO:0016310; GO:0043065; GO:0010942; GO:0031349; GO:2001238; GO:0010628; GO:1905206; GO:0043123; GO:0050729; GO:0070105; GO:0032757; GO:0046330; GO:0045651; GO:0043410; GO:0044093; GO:0060545; GO:0010940; GO:0051092; GO:0042327; GO:0043068; GO:0001934; GO:2000379; GO:0032103; GO:0045944; GO:0032760; GO:1903265; GO:0012501; GO:0097300; GO:0046777; GO:0030163; GO:0006468; GO:0070926; GO:0031326; GO:0010468; GO:0010556; GO:2000377; GO:0034612; GO:0097343; GO:1901026; GO:0007165; GO:0070231; GO:0033209","PTHR44329:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10019|UniProtKB=Q13546","P00006"]
["RIP3",null,"RIPK3","62-46","rb",null,4,2,"n/a","n/a","n/a","n/a","# 2221",".APO., .CD., .CSP., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .OXS., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TRASR., .VIR.",null,"RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 3","activation of protein kinase activity; amyloid fibril formation; apoptotic process; apoptotic signaling pathway; cellular response to hydrogen peroxide; defense response to virus; execution phase of necroptosis; I-kappaB kinase/NF-kappaB signaling; lymph node development; necroptotic process; necroptotic signaling pathway; NIK/NF-kappaB signaling; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ligase activity; positive regulation of necroptotic process; positive regulation of necrotic cell death; positive regulation of NF-kappaB transcription factor activity; positive regulation of oxidoreductase activity; positive regulation of phosphatase activity; positive regulation of reactive oxygen species metabolic process; programmed cell death; programmed necrotic cell death; protein autophosphorylation; protein modification process; protein phosphorylation; reactive oxygen species metabolic process; regulation of activated T cell proliferation; regulation of activation-induced cell death of T cells; regulation of adaptive immune response; regulation of apoptotic process; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; regulation of reactive oxygen species metabolic process; regulation of T cell mediated cytotoxicity; regulation of type II interferon production; signal transduction; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development","ATP binding; identical protein binding; kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transcription coactivator activity; transferase activity","cytoplasm; cytosol; nucleus; protein-containing complex",null,"receptor interacting serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=11035","11035","56532",null,null,"100153263",null,"Q9Y572","Q9QZL0","A0A8I5Y215","A0A8P0SH29","F1SGQ6",null,"GO:0005737; GO:0005829; GO:0005634; GO:0032991","GO:0005524; GO:0042802; GO:0016301; GO:0004704; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0003713; GO:0016740","GO:0032147; GO:1990000; GO:0006915; GO:0097190; GO:0070301; GO:0051607; GO:0097528; GO:0007249; GO:0048535; GO:0070266; GO:0097527; GO:0038061; GO:0016310; GO:0045893; GO:2001244; GO:0051351; GO:0060545; GO:0010940; GO:0051092; GO:0051353; GO:0010922; GO:2000379; GO:0012501; GO:0097300; GO:0046777; GO:0036211; GO:0006468; GO:0072593; GO:0046006; GO:0070235; GO:0002819; GO:0042981; GO:2000452; GO:2000377; GO:0001914; GO:0032649; GO:0007165; GO:0048536; GO:0033077; GO:0043029; GO:0048538","PTHR23257:SF703","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10021|UniProtKB=Q9Y572"]
["RIP3 - phospho","Ser227","RIPK3","70","rb",null,2,6,"n/a","n/a","n/a","n/a","# 2248",".APO., .CD., .CSP., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .OXS., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TRASR., .VIR.",null,"RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 3","activation of protein kinase activity; amyloid fibril formation; apoptotic process; apoptotic signaling pathway; cellular response to hydrogen peroxide; defense response to virus; execution phase of necroptosis; I-kappaB kinase/NF-kappaB signaling; lymph node development; necroptotic process; necroptotic signaling pathway; NIK/NF-kappaB signaling; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ligase activity; positive regulation of necroptotic process; positive regulation of necrotic cell death; positive regulation of NF-kappaB transcription factor activity; positive regulation of oxidoreductase activity; positive regulation of phosphatase activity; positive regulation of reactive oxygen species metabolic process; programmed cell death; programmed necrotic cell death; protein autophosphorylation; protein modification process; protein phosphorylation; reactive oxygen species metabolic process; regulation of activated T cell proliferation; regulation of activation-induced cell death of T cells; regulation of adaptive immune response; regulation of apoptotic process; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; regulation of reactive oxygen species metabolic process; regulation of T cell mediated cytotoxicity; regulation of type II interferon production; signal transduction; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development","ATP binding; identical protein binding; kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transcription coactivator activity; transferase activity","cytoplasm; cytosol; nucleus; protein-containing complex",null,"receptor interacting serine/threonine kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=11035","11035","56532",null,null,"100153263",null,"Q9Y572","Q9QZL0","A0A8I5Y215","A0A8P0SH29","F1SGQ6",null,"GO:0005737; GO:0005829; GO:0005634; GO:0032991","GO:0005524; GO:0042802; GO:0016301; GO:0004704; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0003713; GO:0016740","GO:0032147; GO:1990000; GO:0006915; GO:0097190; GO:0070301; GO:0051607; GO:0097528; GO:0007249; GO:0048535; GO:0070266; GO:0097527; GO:0038061; GO:0016310; GO:0045893; GO:2001244; GO:0051351; GO:0060545; GO:0010940; GO:0051092; GO:0051353; GO:0010922; GO:2000379; GO:0012501; GO:0097300; GO:0046777; GO:0036211; GO:0006468; GO:0072593; GO:0046006; GO:0070235; GO:0002819; GO:0042981; GO:2000452; GO:2000377; GO:0001914; GO:0032649; GO:0007165; GO:0048536; GO:0033077; GO:0043029; GO:0048538","PTHR23257:SF703","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10021|UniProtKB=Q9Y572"]
["RKIP (PBP, PEBP, PEBP1)",null,"PEBP1","21","rb",null,1,2,1,1,1,1,"# 0408",".CSP., .EGFR., .FGFR., .MAPK., .RTK.","FGF signaling pathway; EGF receptor signaling pathway","PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1","negative regulation of MAPK cascade; negative regulation of peptidase activity","ATP binding; enzyme binding; lipid binding; nucleotide binding; peptidase inhibitor activity; phosphatidylethanolamine binding; protein binding; protein kinase binding; RNA binding; serine-type endopeptidase inhibitor activity","cytoplasm; cytosol; extracellular exosome; nucleus","MAPK signaling","phosphatidylethanolamine binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=5037","5037","23980","246145","477501",null,null,"P30086","P70296","M0RB80","Q3YIX4","A0A8W4F7G5","A0A1D5QFC1","GO:0005737; GO:0005829; GO:0070062; GO:0005634","GO:0005524; GO:0019899; GO:0008289; GO:0000166; GO:0030414; GO:0008429; GO:0005515; GO:0019901; GO:0003723; GO:0004867","GO:0043409; GO:0010466","PTHR11362:SF109","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8630|UniProtKB=P30086","P00021; P00018"]
["RNA Polymerase II",null,"ELL2","217","rt",null,1.1000000000000001,4,8,8,8,8,"# 0562",".OP., .OT., .TRASR.",null,"RNA POLYMERASE II ELONGATION FACTOR ELL2","positive regulation of transcription elongation by RNA polymerase II; snRNA transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation by RNA polymerase II","cis-regulatory region sequence-specific DNA binding; protein binding","nucleoplasm; nucleus; transcription elongation factor complex","RNA synthesis","elongation factor for RNA polymerase II 2","http://www.ncbi.nlm.nih.gov/gene/?term=22936","22936","192657",null,null,null,null,"O00472","Q3UKU1","A0A8I5ZQ21","A0A8I3NF65","A0A287A147","F7GJP8","GO:0005654; GO:0005634; GO:0008023","GO:0000987; GO:0005515","GO:0032968; GO:0042795; GO:0006366; GO:0006368","PTHR23288:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17064|UniProtKB=O00472"]
["RNA Polymerase II - phospho","Ser2","ELL2","217","rt",null,1,2.1,8,8,1,8,"# 0565",".OP., .OT., .TRASR.",null,"RNA POLYMERASE II ELONGATION FACTOR ELL2","positive regulation of transcription elongation by RNA polymerase II; snRNA transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation by RNA polymerase II","cis-regulatory region sequence-specific DNA binding; protein binding","nucleoplasm; nucleus; transcription elongation factor complex","RNA synthesis","elongation factor for RNA polymerase II 2","http://www.ncbi.nlm.nih.gov/gene/?term=22936","22936","192657",null,null,null,null,"O00472","Q3UKU1","A0A8I5ZQ21","A0A8I3NF65","A0A287A147","F7GJP8","GO:0005654; GO:0005634; GO:0008023","GO:0000987; GO:0005515","GO:0032968; GO:0042795; GO:0006366; GO:0006368","PTHR23288:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17064|UniProtKB=O00472"]
["RNA Polymerase II - phospho","Ser5","ELL2","217","rt",null,1,1,8,8,1,1.1000000000000001,"# 0563",".OP., .OT., .TRASR.",null,"RNA POLYMERASE II ELONGATION FACTOR ELL2","positive regulation of transcription elongation by RNA polymerase II; snRNA transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation by RNA polymerase II","cis-regulatory region sequence-specific DNA binding; protein binding","nucleoplasm; nucleus; transcription elongation factor complex","RNA synthesis","elongation factor for RNA polymerase II 2","http://www.ncbi.nlm.nih.gov/gene/?term=22936","22936","192657",null,null,null,null,"O00472","Q3UKU1","A0A8I5ZQ21","A0A8I3NF65","A0A287A147","F7GJP8","GO:0005654; GO:0005634; GO:0008023","GO:0000987; GO:0005515","GO:0032968; GO:0042795; GO:0006366; GO:0006368","PTHR23288:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17064|UniProtKB=O00472"]
["RNA Polymerase II - phospho","Ser7","ELL2","217","rt",null,2,4,8,8,8,8,"# 0564",".OP., .OT., .TRASR.",null,"RNA POLYMERASE II ELONGATION FACTOR ELL2","positive regulation of transcription elongation by RNA polymerase II; snRNA transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation by RNA polymerase II","cis-regulatory region sequence-specific DNA binding; protein binding","nucleoplasm; nucleus; transcription elongation factor complex","RNA synthesis","elongation factor for RNA polymerase II 2","http://www.ncbi.nlm.nih.gov/gene/?term=22936","22936","192657",null,null,null,null,"O00472","Q3UKU1","A0A8I5ZQ21","A0A8I3NF65","A0A287A147","F7GJP8","GO:0005654; GO:0005634; GO:0008023","GO:0000987; GO:0005515","GO:0032968; GO:0042795; GO:0006366; GO:0006368","PTHR23288:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17064|UniProtKB=O00472"]
["RNA Polymerase II - phospho","Thr4","ELL2","217","rt",null,4,4,"n/a","n/a","n/a","n/a","# 0566",".OP., .OT., .TRASR.",null,"RNA POLYMERASE II ELONGATION FACTOR ELL2","positive regulation of transcription elongation by RNA polymerase II; snRNA transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation by RNA polymerase II","cis-regulatory region sequence-specific DNA binding; protein binding","nucleoplasm; nucleus; transcription elongation factor complex","RNA synthesis","elongation factor for RNA polymerase II 2","http://www.ncbi.nlm.nih.gov/gene/?term=22936","22936","192657",null,null,null,null,"O00472","Q3UKU1","A0A8I5ZQ21","A0A8I3NF65","A0A287A147","F7GJP8","GO:0005654; GO:0005634; GO:0008023","GO:0000987; GO:0005515","GO:0032968; GO:0042795; GO:0006366; GO:0006368","PTHR23288:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17064|UniProtKB=O00472"]
["RNCAM",null,"NCAM2","93","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0525",null,null,"MICROFIBRILLAR-ASSOCIATED PROTEIN 3-LIKE-RELATED","axonal fasciculation; cell adhesion; neuron cell-cell adhesion; sensory perception of smell","identical protein binding","axon; membrane; neuron projection; nuclear body; plasma membrane",null,"neural cell adhesion molecule 2","http://www.ncbi.nlm.nih.gov/gene/?term=4685","4685","17968",null,"487705",null,null,"O15394","O35136","A0A0G2K7P9","A0A8I3PMR4",null,"A0A1D5QQE5","GO:0030424; GO:0016020; GO:0043005; GO:0016604; GO:0005886","GO:0042802","GO:0007413; GO:0007155; GO:0007158; GO:0007608","PTHR12231:SF231","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7657|UniProtKB=O15394"]
["ROCK1 - cleaved","Asp1113","ROCK1","31","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1062",".ANG., .APH., .APO., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CSP., .DEV., .GPCR., .GPROT., .IMUF., .IMUR., .INFM., .LMIG., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .PLAT., .RAS., .RTK., .ST., .TGFB., .TRASR.","CCKR signaling map; Cytoskeletal regulation by Rho GTPase; Inflammation mediated by chemokine and cytokine signaling pathway","RHO-ASSOCIATED PROTEIN KINASE 1","actin cytoskeleton organization; actomyosin structure organization; aortic valve morphogenesis; apical constriction; apoptotic process; bleb assembly; blood vessel diameter maintenance; cortical actin cytoskeleton organization; embryonic morphogenesis; epithelial to mesenchymal transition; I-kappaB kinase/NF-kappaB signaling; leukocyte cell-cell adhesion; leukocyte migration; leukocyte tethering or rolling; membrane to membrane docking; mitotic cytokinesis; motor neuron apoptotic process; mRNA destabilization; myoblast migration; negative regulation of amyloid precursor protein catabolic process; negative regulation of amyloid-beta formation; negative regulation of angiogenesis; negative regulation of bicellular tight junction assembly; negative regulation of biomineral tissue development; negative regulation of membrane protein ectodomain proteolysis; negative regulation of motor neuron apoptotic process; negative regulation of myosin-light-chain-phosphatase activity; negative regulation of phosphorylation; negative regulation of protein binding; neuron projection arborization; neuron projection development; organelle organization; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; podocyte cell migration; positive regulation of amyloid-beta clearance; positive regulation of autophagy; positive regulation of cardiac muscle hypertrophy; positive regulation of connective tissue replacement; positive regulation of dephosphorylation; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of phosphatase activity; protein localization to plasma membrane; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of actin filament-based process; regulation of amyloid-beta formation; regulation of angiotensin-activated signaling pathway; regulation of autophagy; regulation of cell adhesion; regulation of cell junction assembly; regulation of cell migration; regulation of cell motility; regulation of establishment of cell polarity; regulation of establishment of endothelial barrier; regulation of focal adhesion assembly; regulation of keratinocyte differentiation; regulation of microtubule cytoskeleton organization; regulation of neuron differentiation; regulation of stress fiber assembly; regulation of synapse maturation; regulation of synaptic vesicle endocytosis; response to angiotensin; response to transforming growth factor beta; Rho protein signal transduction; signal transduction; smooth muscle contraction","aspartic-type endopeptidase inhibitor activity; ATP binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; Rho-dependent protein serine/threonine kinase activity; small GTPase binding; tau protein binding; tau-protein kinase activity; transferase activity","amyloid-beta complex; bleb; cell projection; centriole; cytoplasm; cytoplasmic stress granule; cytoskeleton; cytosol; extracellular region; Golgi apparatus; Golgi membrane; lamellipodium; membrane; plasma membrane; ruffle; Schaffer collateral - CA1 synapse; secretory granule lumen","Cytoskeletal signaling","Rho associated coiled-coil containing protein kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=6093","6093","19877","81762",null,null,"698223","Q13464","P70335","D3ZN37","A0A8I3MHP7","A0A287A705","H9EPT5","GO:0106003; GO:0032059; GO:0042995; GO:0005814; GO:0005737; GO:0010494; GO:0005856; GO:0005829; GO:0005576; GO:0005794; GO:0000139; GO:0030027; GO:0016020; GO:0005886; GO:0001726; GO:0098685; GO:0034774","GO:0019828; GO:0005524; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0072518; GO:0031267; GO:0048156; GO:0050321; GO:0016740","GO:0030036; GO:0031032; GO:0003180; GO:0003383; GO:0006915; GO:0032060; GO:0097746; GO:0030866; GO:0048598; GO:0001837; GO:0007249; GO:0007159; GO:0050900; GO:0050901; GO:0022614; GO:0000281; GO:0097049; GO:0061157; GO:0051451; GO:1902992; GO:1902430; GO:0016525; GO:1903347; GO:0070168; GO:0051045; GO:2000672; GO:0035509; GO:0042326; GO:0032091; GO:0140058; GO:0031175; GO:0006996; GO:0018105; GO:0018107; GO:0016310; GO:0090521; GO:1900223; GO:0010508; GO:0010613; GO:1905205; GO:0035306; GO:0051894; GO:0010628; GO:0043410; GO:0010922; GO:0072659; GO:0006468; GO:0032956; GO:0032970; GO:1902003; GO:0110061; GO:0010506; GO:0030155; GO:1901888; GO:0030334; GO:2000145; GO:2000114; GO:1903140; GO:0051893; GO:0045616; GO:0070507; GO:0045664; GO:0051492; GO:0090128; GO:1900242; GO:1990776; GO:0071559; GO:0007266; GO:0007165; GO:0006939","PTHR22988:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10251|UniProtKB=Q13464","P06959; P00016; P00031"]
["Ron",null,"MST1R","170","ms",null,1.1000000000000001,4,"n/a","n/a","n/a","n/a","# 1942",".CCP., .CP., .CSP., .IIR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .VIR.",null,"MACROPHAGE-STIMULATING PROTEIN RECEPTOR","cell migration; defense response; immune system process; innate immune response; macrophage colony-stimulating factor signaling pathway; nervous system development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive regulation of cell population proliferation; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; protein phosphorylation; response to virus; signal transduction; single fertilization; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; enzyme binding; kinase activity; macrophage colony-stimulating factor receptor activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; membrane; plasma membrane; receptor complex; stress fiber; vacuole",null,"macrophage stimulating 1 receptor","http://www.ncbi.nlm.nih.gov/gene/?term=4486","4486","19882",null,"444854",null,null,"Q04912","Q62190","A0A8I6A5T6","A0A8P0SPB9","A0A286ZJ49","F7ED27","GO:0009925; GO:0009986; GO:0016020; GO:0005886; GO:0043235; GO:0001725; GO:0005773","GO:0005524; GO:0019899; GO:0016301; GO:0005011; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714","GO:0016477; GO:0006952; GO:0002376; GO:0045087; GO:0038145; GO:0007399; GO:0018108; GO:0006909; GO:0016310; GO:0008284; GO:0033674; GO:0043406; GO:0051897; GO:0006468; GO:0009615; GO:0007165; GO:0007338; GO:0007169","PTHR24416:SF113","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7381|UniProtKB=Q04912"]
["Ron",null,"MST1R","150, 145","rb",null,1,4,"n/a","n/a","n/a","n/a","# 1943",".CCP., .CP., .CSP., .IIR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .VIR.",null,"MACROPHAGE-STIMULATING PROTEIN RECEPTOR","cell migration; defense response; immune system process; innate immune response; macrophage colony-stimulating factor signaling pathway; nervous system development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive regulation of cell population proliferation; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; protein phosphorylation; response to virus; signal transduction; single fertilization; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; enzyme binding; kinase activity; macrophage colony-stimulating factor receptor activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; membrane; plasma membrane; receptor complex; stress fiber; vacuole",null,"macrophage stimulating 1 receptor","http://www.ncbi.nlm.nih.gov/gene/?term=4486","4486","19882",null,"444854",null,null,"Q04912","Q62190","A0A8I6A5T6","A0A8P0SPB9","A0A286ZJ49","F7ED27","GO:0009925; GO:0009986; GO:0016020; GO:0005886; GO:0043235; GO:0001725; GO:0005773","GO:0005524; GO:0019899; GO:0016301; GO:0005011; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714","GO:0016477; GO:0006952; GO:0002376; GO:0045087; GO:0038145; GO:0007399; GO:0018108; GO:0006909; GO:0016310; GO:0008284; GO:0033674; GO:0043406; GO:0051897; GO:0006468; GO:0009615; GO:0007165; GO:0007338; GO:0007169","PTHR24416:SF113","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7381|UniProtKB=Q04912"]
["Ron - phospho","Tyr1353","MST1R","152","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1989",".CCP., .CP., .CSP., .IIR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .VIR.",null,"MACROPHAGE-STIMULATING PROTEIN RECEPTOR","cell migration; defense response; immune system process; innate immune response; macrophage colony-stimulating factor signaling pathway; nervous system development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive regulation of cell population proliferation; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; protein phosphorylation; response to virus; signal transduction; single fertilization; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; enzyme binding; kinase activity; macrophage colony-stimulating factor receptor activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; membrane; plasma membrane; receptor complex; stress fiber; vacuole",null,"macrophage stimulating 1 receptor","http://www.ncbi.nlm.nih.gov/gene/?term=4486","4486","19882",null,"444854",null,null,"Q04912","Q62190","A0A8I6A5T6","A0A8P0SPB9","A0A286ZJ49","F7ED27","GO:0009925; GO:0009986; GO:0016020; GO:0005886; GO:0043235; GO:0001725; GO:0005773","GO:0005524; GO:0019899; GO:0016301; GO:0005011; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714","GO:0016477; GO:0006952; GO:0002376; GO:0045087; GO:0038145; GO:0007399; GO:0018108; GO:0006909; GO:0016310; GO:0008284; GO:0033674; GO:0043406; GO:0051897; GO:0006468; GO:0009615; GO:0007165; GO:0007338; GO:0007169","PTHR24416:SF113","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7381|UniProtKB=Q04912"]
["Ron - phospho","Tyr1360","MST1R","25","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1981",".CCP., .CP., .CSP., .IIR., .IMU., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .VIR.",null,"MACROPHAGE-STIMULATING PROTEIN RECEPTOR","cell migration; defense response; immune system process; innate immune response; macrophage colony-stimulating factor signaling pathway; nervous system development; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; positive regulation of cell population proliferation; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; protein phosphorylation; response to virus; signal transduction; single fertilization; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; enzyme binding; kinase activity; macrophage colony-stimulating factor receptor activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","basal plasma membrane; cell surface; membrane; plasma membrane; receptor complex; stress fiber; vacuole",null,"macrophage stimulating 1 receptor","http://www.ncbi.nlm.nih.gov/gene/?term=4486","4486","19882",null,"444854",null,null,"Q04912","Q62190","A0A8I6A5T6","A0A8P0SPB9","A0A286ZJ49","F7ED27","GO:0009925; GO:0009986; GO:0016020; GO:0005886; GO:0043235; GO:0001725; GO:0005773","GO:0005524; GO:0019899; GO:0016301; GO:0005011; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714","GO:0016477; GO:0006952; GO:0002376; GO:0045087; GO:0038145; GO:0007399; GO:0018108; GO:0006909; GO:0016310; GO:0008284; GO:0033674; GO:0043406; GO:0051897; GO:0006468; GO:0009615; GO:0007165; GO:0007338; GO:0007169","PTHR24416:SF113","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7381|UniProtKB=Q04912"]
["ROR1/ROR2",null,"ROR1","120","gt",null,2,6,"n/a","n/a","n/a","n/a","# 2252",".CSP., .DEV., .IMUF., .MAPK., .NFKB., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR., .WNT.",null,"INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1","astrocyte development; inner ear development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of kinase activity; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphatidylinositol 3-kinase signaling; protein phosphorylation; sensory perception of sound; transmembrane receptor protein tyrosine kinase signaling pathway; Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway","ATP binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; kinase activity; nucleotide binding; protein binding; protein kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; Wnt receptor activity; Wnt-protein binding","axon; axon terminus; cell projection; cell surface; cytoplasm; membrane; plasma membrane; receptor complex; stress fiber",null,"receptor tyrosine kinase like orphan receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=4919","4919","26563",null,null,null,null,"Q01973","Q9Z139","A0A8I5ZQX3","A0A8I3MPB6","A0A5G2R5S4","A0A5F7ZDM0","GO:0030424; GO:0043679; GO:0042995; GO:0009986; GO:0005737; GO:0016020; GO:0005886; GO:0043235; GO:0001725","GO:0005524; GO:1904929; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0016740; GO:0004714; GO:0042813; GO:0017147","GO:0014002; GO:0048839; GO:0018108; GO:0016310; GO:0070374; GO:0043123; GO:0033674; GO:0010976; GO:0051092; GO:0014068; GO:0006468; GO:0007605; GO:0007169; GO:0016055; GO:0060071","PTHR24416:SF134","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10256|UniProtKB=Q01973"]
["RPA2 p34",null,"RPA2","32","ms",null,1,4,8,8,1,8,"# 1078",".CCP., .CCY., .CD., .CSP., .DDR., .DREP., .OP.","DNA replication","REPLICATION PROTEIN A 30 KDA SUBUNIT-RELATED","base-excision repair; cellular response to DNA damage stimulus; DNA recombination; DNA repair; DNA replication; double-strand break repair via homologous recombination; mismatch repair; mitotic G1 DNA damage checkpoint signaling; nucleotide-excision repair; protein localization to chromosome; regulation of DNA damage checkpoint; regulation of double-strand break repair via homologous recombination; telomere maintenance","damaged DNA binding; DNA binding; enzyme binding; G-rich strand telomeric DNA binding; protein binding; protein N-terminus binding; protein phosphatase binding; single-stranded DNA binding; ubiquitin protein ligase binding","chromatin; chromosome, telomeric region; DNA replication factor A complex; nuclear body; nucleoplasm; nucleus; PML body; site of double-strand break",null,"replication protein A2","http://www.ncbi.nlm.nih.gov/gene/?term=6118","6118",null,"59102",null,null,null,"P15927","F6V8R7","Q63528","A0A8P0SGP1","A0A5G2RE33","F7EYD7","GO:0000785; GO:0000781; GO:0005662; GO:0016604; GO:0005654; GO:0005634; GO:0016605; GO:0035861","GO:0003684; GO:0003677; GO:0019899; GO:0098505; GO:0005515; GO:0047485; GO:0019903; GO:0003697; GO:0031625","GO:0006284; GO:0006974; GO:0006310; GO:0006281; GO:0006260; GO:0000724; GO:0006298; GO:0031571; GO:0006289; GO:0034502; GO:2000001; GO:0010569; GO:0000723","PTHR13989:SF43","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10290|UniProtKB=P15927","P00017"]
["RPL14",null,"RPL14","23","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2991",null,null,"60S RIBOSOMAL PROTEIN L14","cytoplasmic translation; ribosomal large subunit biogenesis; rRNA processing; translation","cadherin binding; protein binding; RNA binding; structural constituent of ribosome","cytoplasm; cytosol; cytosolic large ribosomal subunit; cytosolic ribosome; extracellular exosome; membrane; postsynaptic density; ribonucleoprotein complex; ribosome; synapse",null,"ribosomal protein L14","http://www.ncbi.nlm.nih.gov/gene/?term=9045","9045","67115","306079","477031","100739087",null,"P50914","Q9CR57","Q6TUH8","A0A8I3RZN5","I3LIZ8",null,"GO:0005737; GO:0005829; GO:0022625; GO:0022626; GO:0070062; GO:0016020; GO:0014069; GO:1990904; GO:0005840; GO:0045202","GO:0045296; GO:0005515; GO:0003723; GO:0003735","GO:0002181; GO:0042273; GO:0006364; GO:0006412","PTHR11127:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10305|UniProtKB=P50914"]
["RPL8",null,"RPL8","28","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1654",null,null,"60S RIBOSOMAL PROTEIN L8","cytoplasmic translation; translation","protein binding; RNA binding; rRNA binding; structural constituent of ribosome","cytoplasm; cytosol; cytosolic large ribosomal subunit; cytosolic ribosome; focal adhesion; large ribosomal subunit; membrane; polysomal ribosome; postsynapse; postsynaptic density; ribonucleoprotein complex; ribosome; synapse",null,"ribosomal protein L8","http://www.ncbi.nlm.nih.gov/gene/?term=6132","6132","26961",null,null,null,"708535","P62917","P62918",null,"A0A8I3NAJ7","A0A5G2R4W2","G7N0D2","GO:0005737; GO:0005829; GO:0022625; GO:0022626; GO:0005925; GO:0015934; GO:0016020; GO:0042788; GO:0098794; GO:0014069; GO:1990904; GO:0005840; GO:0045202","GO:0005515; GO:0003723; GO:0019843; GO:0003735","GO:0002181; GO:0006412","PTHR13691:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10368|UniProtKB=P62917"]
["RPL9",null,"RPL9","22","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2992",null,null,"60S RIBOSOMAL PROTEIN L9","cytoplasmic translation; translation","protein binding; RNA binding; rRNA binding; structural constituent of ribosome","cytoplasm; cytosol; cytosolic large ribosomal subunit; cytosolic ribosome; focal adhesion; membrane; nucleus; ribonucleoprotein complex; ribosome",null,"ribosomal protein L9","http://www.ncbi.nlm.nih.gov/gene/?term=6133","6133",null,null,"479109",null,null,"P32969",null,null,"A0A8I3MSX4",null,null,"GO:0005737; GO:0005829; GO:0022625; GO:0022626; GO:0005925; GO:0016020; GO:0005634; GO:1990904; GO:0005840","GO:0005515; GO:0003723; GO:0019843; GO:0003735","GO:0002181; GO:0006412","PTHR11655:SF46","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10369|UniProtKB=P32969"]
["RPS27L",null,"RPS27L","9","rb",null,2,8,"n/a","n/a","n/a","n/a","# 2984",".APO., .CCP., .CCY., .CD., .CSP., .OP., .OT., .P53S., .TRASR.",null,"40S RIBOSOMAL PROTEIN S27-LIKE","activation of cysteine-type endopeptidase activity involved in apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mitotic G1 DNA damage checkpoint signaling; positive regulation of translation; ribosomal small subunit assembly; translation","cysteine-type endopeptidase activator activity involved in apoptotic process; metal ion binding; protein binding; RNA binding; structural constituent of ribosome; translation activator activity","cytosolic small ribosomal subunit; nucleus; ribonucleoprotein complex; ribosome",null,"ribosomal protein S27 like","http://www.ncbi.nlm.nih.gov/gene/?term=51065","51065","67941","681429",null,null,"705483","Q71UM5","Q6ZWY3","P24051","A0A8I3Q4U6","A0A5G2Q9T7","H9FV62","GO:0022627; GO:0005634; GO:1990904; GO:0005840","GO:0008656; GO:0046872; GO:0005515; GO:0003723; GO:0003735; GO:0008494","GO:0006919; GO:0006978; GO:0042771; GO:0031571; GO:0045727; GO:0000028; GO:0006412","PTHR11594:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18476|UniProtKB=Q71UM5"]
["RPS5",null,"RPS5","23","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2985",null,null,"40S RIBOSOMAL PROTEIN S5","cytoplasmic translation; regulation of translational fidelity; ribosomal small subunit assembly; translation; translational initiation","mRNA binding; protein binding; RNA binding; rRNA binding; structural constituent of ribosome","cytoplasm; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; extracellular exosome; focal adhesion; membrane; nucleoplasm; ribonucleoprotein complex; ribosome; small ribosomal subunit",null,"ribosomal protein S5","http://www.ncbi.nlm.nih.gov/gene/?term=6193","6193",null,"25538",null,null,"711259","P46782","D3YYM6","A0A0G2K200","A0A8I3MB70","A0A287AEM2","F7HNZ0","GO:0005737; GO:0005829; GO:0022626; GO:0022627; GO:0070062; GO:0005925; GO:0016020; GO:0005654; GO:1990904; GO:0005840; GO:0015935","GO:0003729; GO:0005515; GO:0003723; GO:0019843; GO:0003735","GO:0002181; GO:0006450; GO:0000028; GO:0006412; GO:0006413","PTHR11205:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10426|UniProtKB=P46782"]
["RSK 1",null,"RPS6KA1","90","rb",null,2,2,1,7,2,2,"# 0246",".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-1","apoptotic process; cell cycle; chemical synaptic transmission; hepatocyte proliferation; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of TOR signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of DNA-templated transcription; positive regulation of hepatic stellate cell activation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of DNA-templated transcription in response to stress; regulation of translation in response to stress; signal transduction","ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus; synapse","MAPK signaling","ribosomal protein S6 kinase A1","http://www.ncbi.nlm.nih.gov/gene/?term=6195","6195","20111",null,null,null,null,"Q15418","P18653","A0A0G2JZ20","A0A8I3NAU2","A0A286ZNG1","A0A1D5QBJ3","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0045202","GO:0005524; GO:0043027; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0006915; GO:0007049; GO:0007268; GO:0072574; GO:0035556; GO:0043066; GO:0043154; GO:0032007; GO:0018105; GO:0016310; GO:0045597; GO:0030307; GO:0045893; GO:2000491; GO:0045944; GO:0006468; GO:0043620; GO:0043555; GO:0007165","PTHR24351:SF43","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10430|UniProtKB=Q15418","P06959; P00032; P00036; P04393; P00047"]
["RSK 1 - phospho","Ser380","RPS6KA1","90","rb",null,1,2,6,7,8,8,"# 1824",".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-1","apoptotic process; cell cycle; chemical synaptic transmission; hepatocyte proliferation; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of TOR signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of DNA-templated transcription; positive regulation of hepatic stellate cell activation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of DNA-templated transcription in response to stress; regulation of translation in response to stress; signal transduction","ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus; synapse","MAPK signaling","ribosomal protein S6 kinase A1","http://www.ncbi.nlm.nih.gov/gene/?term=6195","6195","20111",null,null,null,null,"Q15418","P18653","A0A0G2JZ20","A0A8I3NAU2","A0A286ZNG1","A0A1D5QBJ3","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0045202","GO:0005524; GO:0043027; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0006915; GO:0007049; GO:0007268; GO:0072574; GO:0035556; GO:0043066; GO:0043154; GO:0032007; GO:0018105; GO:0016310; GO:0045597; GO:0030307; GO:0045893; GO:2000491; GO:0045944; GO:0006468; GO:0043620; GO:0043555; GO:0007165","PTHR24351:SF43","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10430|UniProtKB=Q15418","P06959; P00032; P00036; P04393; P00047"]
["RSK 1 - phospho","Thr573","RPS6KA1","83","rb",null,1,1,1,8,8,8,"# 1968",".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-1","apoptotic process; cell cycle; chemical synaptic transmission; hepatocyte proliferation; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of TOR signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of DNA-templated transcription; positive regulation of hepatic stellate cell activation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of DNA-templated transcription in response to stress; regulation of translation in response to stress; signal transduction","ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus; synapse","MAPK signaling","ribosomal protein S6 kinase A1","http://www.ncbi.nlm.nih.gov/gene/?term=6195","6195","20111",null,null,null,null,"Q15418","P18653","A0A0G2JZ20","A0A8I3NAU2","A0A286ZNG1","A0A1D5QBJ3","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0045202","GO:0005524; GO:0043027; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0006915; GO:0007049; GO:0007268; GO:0072574; GO:0035556; GO:0043066; GO:0043154; GO:0032007; GO:0018105; GO:0016310; GO:0045597; GO:0030307; GO:0045893; GO:2000491; GO:0045944; GO:0006468; GO:0043620; GO:0043555; GO:0007165","PTHR24351:SF43","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10430|UniProtKB=Q15418","P06959; P00032; P00036; P04393; P00047"]
["RSK 1/2/3",null,"RPS6KA1, RPS6KA3, RPS6KA2","90","rb",null,2,2,1,6,2,2,"# 0870",".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-1; RIBOSOMAL PROTEIN S6 KINASE ALPHA-3; RIBOSOMAL PROTEIN S6 KINASE ALPHA-2","apoptotic process; cell cycle; chemical synaptic transmission; hepatocyte proliferation; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of TOR signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of DNA-templated transcription; positive regulation of hepatic stellate cell activation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of DNA-templated transcription in response to stress; regulation of translation in response to stress; signal transduction; central nervous system development; response to lipopolysaccharide; skeletal system development; toll-like receptor signaling pathway; brain renin-angiotensin system; cardiac muscle cell apoptotic process; cellular response to carbohydrate stimulus; heart contraction; heart development; negative regulation of cell cycle; negative regulation of cell population proliferation; negative regulation of meiotic nuclear division; oocyte maturation; positive regulation of apoptotic process; positive regulation of gene expression; regulation of protein processing","ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity; protein kinase binding","cytoplasm; cytosol; nucleoplasm; nucleus; synapse; nucleolus; meiotic spindle; spindle","MAPK signaling","ribosomal protein S6 kinase A1; ribosomal protein S6 kinase A3; ribosomal protein S6 kinase A2","http://www.ncbi.nlm.nih.gov/gene/?term=6195, http://www.ncbi.nlm.nih.gov/gene/?term=6197, http://www.ncbi.nlm.nih.gov/gene/?term=6196","6195, 6197, 6196","20111, 110651, 20112","NA, 501560",null,null,"NA, 716899","Q15418, P51812, Q15349","P18653, P18654, Q9WUT3","A0A0G2JZ20, A0A8I5ZNU1, A0A8I5Y0U0","A0A8I3NAU2, A0A8I3MP05","A0A286ZNG1, A0A287A3K5, A0A286ZUB4","A0A1D5QBJ3, A0A1D5Q6C8, A0A1D5QGV7","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0045202; GO:0005730; GO:0072687; GO:0005819","GO:0005524; GO:0043027; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740; GO:0019901","GO:0006915; GO:0007049; GO:0007268; GO:0072574; GO:0035556; GO:0043066; GO:0043154; GO:0032007; GO:0018105; GO:0016310; GO:0045597; GO:0030307; GO:0045893; GO:2000491; GO:0045944; GO:0006468; GO:0043620; GO:0043555; GO:0007165; GO:0007417; GO:0032496; GO:0001501; GO:0002224; GO:0002035; GO:0010659; GO:0071322; GO:0060047; GO:0007507; GO:0045786; GO:0008285; GO:0045835; GO:0001556; GO:0043065; GO:0010628; GO:0070613","PTHR24351:SF43; PTHR24351:SF58; PTHR24351:SF213","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10430|UniProtKB=Q15418; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10432|UniProtKB=P51812; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10431|UniProtKB=Q15349","P06959; P00032; P00036; P04393; P00047"]
["RSK 1/3 - phospho","Thr359/Ser363","RPS6KA1, RPS6KA2","90","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2375",".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","CCKR signaling map; Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-1; RIBOSOMAL PROTEIN S6 KINASE ALPHA-2","apoptotic process; cell cycle; chemical synaptic transmission; hepatocyte proliferation; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of TOR signaling; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of DNA-templated transcription; positive regulation of hepatic stellate cell activation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of DNA-templated transcription in response to stress; regulation of translation in response to stress; signal transduction; brain renin-angiotensin system; cardiac muscle cell apoptotic process; cellular response to carbohydrate stimulus; heart contraction; heart development; negative regulation of cell cycle; negative regulation of cell population proliferation; negative regulation of meiotic nuclear division; oocyte maturation; positive regulation of apoptotic process; positive regulation of gene expression; regulation of protein processing","ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cytoplasm; cytosol; nucleoplasm; nucleus; synapse; meiotic spindle; spindle",null,"ribosomal protein S6 kinase A1; ribosomal protein S6 kinase A2","http://www.ncbi.nlm.nih.gov/gene/?term=6195, http://www.ncbi.nlm.nih.gov/gene/?term=6196","6195, 6196","20111, 20112",null,null,null,"NA, 716899","Q15418, Q15349","P18653, Q9WUT3","A0A0G2JZ20, A0A8I5Y0U0","A0A8I3NAU2, A0A8I3MP05","A0A286ZNG1, A0A286ZUB4","A0A1D5QBJ3, A0A1D5QGV7","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0045202; GO:0072687; GO:0005819","GO:0005524; GO:0043027; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0006915; GO:0007049; GO:0007268; GO:0072574; GO:0035556; GO:0043066; GO:0043154; GO:0032007; GO:0018105; GO:0016310; GO:0045597; GO:0030307; GO:0045893; GO:2000491; GO:0045944; GO:0006468; GO:0043620; GO:0043555; GO:0007165; GO:0002035; GO:0010659; GO:0071322; GO:0060047; GO:0007507; GO:0045786; GO:0008285; GO:0045835; GO:0001556; GO:0043065; GO:0010628; GO:0070613","PTHR24351:SF43; PTHR24351:SF213","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10430|UniProtKB=Q15418; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10431|UniProtKB=Q15349","P06959; P00032; P00036; P04393; P00047"]
["RSK 3",null,"RPS6KA2","90","rb",null,2,2,1,2,2,2,"# 1816",".APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-2","brain renin-angiotensin system; cardiac muscle cell apoptotic process; cellular response to carbohydrate stimulus; chemical synaptic transmission; heart contraction; heart development; intracellular signal transduction; negative regulation of cell cycle; negative regulation of cell population proliferation; negative regulation of meiotic nuclear division; oocyte maturation; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of gene expression; protein phosphorylation; regulation of protein processing; signal transduction","ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cytoplasm; cytosol; meiotic spindle; nucleoplasm; nucleus; spindle; synapse","MAPK signaling","ribosomal protein S6 kinase A2","http://www.ncbi.nlm.nih.gov/gene/?term=6196","6196","20112",null,null,null,"716899","Q15349","Q9WUT3","A0A8I5Y0U0","A0A8I3MP05","A0A286ZUB4","A0A1D5QGV7","GO:0005737; GO:0005829; GO:0072687; GO:0005654; GO:0005634; GO:0005819; GO:0045202","GO:0005524; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0002035; GO:0010659; GO:0071322; GO:0007268; GO:0060047; GO:0007507; GO:0035556; GO:0045786; GO:0008285; GO:0045835; GO:0001556; GO:0018105; GO:0016310; GO:0043065; GO:0010628; GO:0006468; GO:0070613; GO:0007165","PTHR24351:SF213","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10431|UniProtKB=Q15349","P00032; P00036; P04393; P00047"]
["RSK 3 - phospho","Thr356/Ser360","RPS6KA2","90","rb",null,1,1.1000000000000001,"n/a","n/a","n/a","n/a","# 2095",".APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-2","brain renin-angiotensin system; cardiac muscle cell apoptotic process; cellular response to carbohydrate stimulus; chemical synaptic transmission; heart contraction; heart development; intracellular signal transduction; negative regulation of cell cycle; negative regulation of cell population proliferation; negative regulation of meiotic nuclear division; oocyte maturation; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of gene expression; protein phosphorylation; regulation of protein processing; signal transduction","ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cytoplasm; cytosol; meiotic spindle; nucleoplasm; nucleus; spindle; synapse",null,"ribosomal protein S6 kinase A2","http://www.ncbi.nlm.nih.gov/gene/?term=6196","6196","20112",null,null,null,"716899","Q15349","Q9WUT3","A0A8I5Y0U0","A0A8I3MP05","A0A286ZUB4","A0A1D5QGV7","GO:0005737; GO:0005829; GO:0072687; GO:0005654; GO:0005634; GO:0005819; GO:0045202","GO:0005524; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0004711; GO:0016740","GO:0002035; GO:0010659; GO:0071322; GO:0007268; GO:0060047; GO:0007507; GO:0035556; GO:0045786; GO:0008285; GO:0045835; GO:0001556; GO:0018105; GO:0016310; GO:0043065; GO:0010628; GO:0006468; GO:0070613; GO:0007165","PTHR24351:SF213","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10431|UniProtKB=Q15349","P00032; P00036; P04393; P00047"]
["RSK 4",null,"RPS6KA6","90","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0254",".CD., .CSP., .INS., .INT., .MAPK., .MTOR., .OPA., .P53S., .PDGF., .RAS., .RTK., .SREME., .ST.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-6","central nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; intracellular signal transduction; negative regulation of embryonic development; negative regulation of ERK1 and ERK2 cascade; negative regulation of mesoderm development; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation; signal transduction","ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cytoplasm; cytosol; fibrillar center; mitochondrion; nucleolus; nucleoplasm; nucleus","MAPK signaling","ribosomal protein S6 kinase A6","http://www.ncbi.nlm.nih.gov/gene/?term=27330","27330",null,null,null,"100522294",null,"Q9UK32","A2CEE5","A0A0G2JXA6","A0A8I3PEI6","A0A480L5M3","A0A1D5QL06","GO:0005737; GO:0005829; GO:0001650; GO:0005739; GO:0005730; GO:0005654; GO:0005634","GO:0005524; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004711; GO:0016740","GO:0007417; GO:0006978; GO:0035556; GO:0045992; GO:0070373; GO:2000381; GO:0018105; GO:0016310; GO:0006468; GO:0007165","PTHR24351:SF98","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10435|UniProtKB=Q9UK32","P00032; P00036; P04393; P00047"]
["RSK 4 - phospho","Ser235","RPS6KA6","90","rb",null,6,1,2,7,8,8,"# 0218",".CD., .CSP., .INS., .INT., .MAPK., .MTOR., .OPA., .P53S., .PDGF., .RAS., .RTK., .SREME., .ST.","Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade; Interleukin signaling pathway; Ras Pathway; PDGF signaling pathway","RIBOSOMAL PROTEIN S6 KINASE ALPHA-6","central nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; intracellular signal transduction; negative regulation of embryonic development; negative regulation of ERK1 and ERK2 cascade; negative regulation of mesoderm development; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation; signal transduction","ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; ribosomal protein S6 kinase activity; transferase activity","cytoplasm; cytosol; fibrillar center; mitochondrion; nucleolus; nucleoplasm; nucleus","MAPK signaling","ribosomal protein S6 kinase A6","http://www.ncbi.nlm.nih.gov/gene/?term=27330","27330",null,null,null,"100522294",null,"Q9UK32","A2CEE5","A0A0G2JXA6","A0A8I3PEI6","A0A480L5M3","A0A1D5QL06","GO:0005737; GO:0005829; GO:0001650; GO:0005739; GO:0005730; GO:0005654; GO:0005634","GO:0005524; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004711; GO:0016740","GO:0007417; GO:0006978; GO:0035556; GO:0045992; GO:0070373; GO:2000381; GO:0018105; GO:0016310; GO:0006468; GO:0007165","PTHR24351:SF98","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10435|UniProtKB=Q9UK32","P00032; P00036; P04393; P00047"]
["RXR alpha",null,"RXRA","53","ms",null,6,4,8,8,8,8,"# 1603",".CANCER., .CANPTHW., .CSP., .NSCLC., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TCD., .TMAT., .TRASR., .TYR.","Vitamin D metabolism and pathway","RETINOIC ACID RECEPTOR RXR-ALPHA","anatomical structure development; cell differentiation; hormone-mediated signaling pathway; mRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; peroxisome proliferator activated receptor signaling pathway; positive regulation of bone mineralization; positive regulation of cholesterol efflux; positive regulation of DNA-templated transcription; positive regulation of thyroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transporter activity; positive regulation of vitamin D receptor signaling pathway; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to retinoic acid; retinoic acid receptor signaling pathway; steroid hormone mediated signaling pathway","DNA binding; DNA binding domain binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; identical protein binding; ion binding; LBD domain binding; metal ion binding; nuclear receptor activity; nuclear receptor binding; nuclear steroid receptor activity; nuclear vitamin D receptor binding; peptide binding; protein binding; retinoic acid binding; retinoic acid-responsive element binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coregulator binding; vitamin D response element binding; zinc ion binding","chromatin; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; receptor complex; RNA polymerase II transcription regulator complex; transcription regulator complex",null,"retinoid X receptor alpha","http://www.ncbi.nlm.nih.gov/gene/?term=6256","6256","20181",null,null,null,null,"P19793","P28700","A0A8I6A846","A0A8I3NIH7",null,"A0A1D5QGJ9","GO:0000785; GO:0005737; GO:0005829; GO:0005739; GO:0005654; GO:0005634; GO:0043235; GO:0090575; GO:0005667","GO:0003677; GO:0050692; GO:0003700; GO:0000981; GO:0003690; GO:0019899; GO:0042802; GO:0043167; GO:0050693; GO:0046872; GO:0004879; GO:0016922; GO:0003707; GO:0042809; GO:0042277; GO:0005515; GO:0001972; GO:0044323; GO:0000978; GO:0000977; GO:0043565; GO:1990837; GO:0000976; GO:0001221; GO:0070644; GO:0008270","GO:0048856; GO:0030154; GO:0009755; GO:0042789; GO:0000122; GO:0035357; GO:0030501; GO:0010875; GO:0045893; GO:0002157; GO:0045944; GO:0032411; GO:0070564; GO:0006355; GO:0006357; GO:0032526; GO:0048384; GO:0043401","PTHR24083:SF39","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10477|UniProtKB=P19793","P04396"]
["S6 ribosomal",null,"RPS6","32","ms",null,2,1,"n/a","n/a","n/a","n/a","# 2175",".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .HIF., .IMUF., .INS., .MTOR., .OP., .OPA., .PI3K., .RTK., .SREME., .TCR.","CCKR signaling map","40S RIBOSOMAL PROTEIN S6","activation-induced cell death of T cells; cytoplasmic translation; erythrocyte development; G1/S transition of mitotic cell cycle; gastrulation; glucose homeostasis; mammalian oogenesis stage; mitotic cell cycle; negative regulation of apoptotic process; placenta development; positive regulation of apoptotic process; positive regulation of cell population proliferation; ribosomal small subunit biogenesis; rRNA processing; T cell differentiation in thymus; T cell proliferation involved in immune response; TOR signaling; translation","protein binding; protein kinase binding; RNA binding; structural constituent of ribosome","cell body; cellular anatomical entity; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; dendrite; endoplasmic reticulum; membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; polysome; ribonucleoprotein complex; ribosome; small ribosomal subunit","Translational control","ribosomal protein S6","http://www.ncbi.nlm.nih.gov/gene/?term=6194","6194","105244208","29304","474722",null,null,"P62753","P62754","P62755","A0A8I3NUU7","A0A287BCW5","F6YAF2","GO:0044297; GO:0110165; GO:0005737; GO:0036464; GO:0005829; GO:0022626; GO:0022627; GO:0030425; GO:0005783; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:0048471; GO:0005844; GO:1990904; GO:0005840; GO:0015935","GO:0005515; GO:0019901; GO:0003723; GO:0003735","GO:0006924; GO:0002181; GO:0048821; GO:0000082; GO:0007369; GO:0042593; GO:0022605; GO:0000278; GO:0043066; GO:0001890; GO:0043065; GO:0008284; GO:0042274; GO:0006364; GO:0033077; GO:0002309; GO:0031929; GO:0006412","PTHR11502:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10429|UniProtKB=P62753","P06959"]
["S6 ribosomal protein",null,"RPS6","32","rb",null,2,1,1,8,8,8,"BG/MP # 054",".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .EGFR., .HIF., .IMUF., .INS., .MTOR., .OP., .OPA., .PI3K., .RTK., .SREME., .TCR.","CCKR signaling map","40S RIBOSOMAL PROTEIN S6","activation-induced cell death of T cells; cytoplasmic translation; erythrocyte development; G1/S transition of mitotic cell cycle; gastrulation; glucose homeostasis; mammalian oogenesis stage; mitotic cell cycle; negative regulation of apoptotic process; placenta development; positive regulation of apoptotic process; positive regulation of cell population proliferation; ribosomal small subunit biogenesis; rRNA processing; T cell differentiation in thymus; T cell proliferation involved in immune response; TOR signaling; translation","protein binding; protein kinase binding; RNA binding; structural constituent of ribosome","cell body; cellular anatomical entity; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; dendrite; endoplasmic reticulum; membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; polysome; ribonucleoprotein complex; ribosome; small ribosomal subunit","Translational control","ribosomal protein S6","http://www.ncbi.nlm.nih.gov/gene/?term=6194","6194","105244208","29304","474722",null,null,"P62753","P62754","P62755","A0A8I3NUU7","A0A287BCW5","F6YAF2","GO:0044297; GO:0110165; GO:0005737; GO:0036464; GO:0005829; GO:0022626; GO:0022627; GO:0030425; GO:0005783; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:0048471; GO:0005844; GO:1990904; GO:0005840; GO:0015935","GO:0005515; GO:0019901; GO:0003723; GO:0003735","GO:0006924; GO:0002181; GO:0048821; GO:0000082; GO:0007369; GO:0042593; GO:0022605; GO:0000278; GO:0043066; GO:0001890; GO:0043065; GO:0008284; GO:0042274; GO:0006364; GO:0033077; GO:0002309; GO:0031929; GO:0006412","PTHR11502:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10429|UniProtKB=P62753","P06959"]
["S6 ribosomal protein - phospho","Ser235/Ser236","RPS6","32","rb",null,2,1,1,1,1,1,"# 3031",".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .EGFR., .HIF., .IMUF., .INS., .MTOR., .OP., .OPA., .PI3K., .RTK., .SREME., .TCR.","CCKR signaling map","40S RIBOSOMAL PROTEIN S6","activation-induced cell death of T cells; cytoplasmic translation; erythrocyte development; G1/S transition of mitotic cell cycle; gastrulation; glucose homeostasis; mammalian oogenesis stage; mitotic cell cycle; negative regulation of apoptotic process; placenta development; positive regulation of apoptotic process; positive regulation of cell population proliferation; ribosomal small subunit biogenesis; rRNA processing; T cell differentiation in thymus; T cell proliferation involved in immune response; TOR signaling; translation","protein binding; protein kinase binding; RNA binding; structural constituent of ribosome","cell body; cellular anatomical entity; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; dendrite; endoplasmic reticulum; membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; polysome; ribonucleoprotein complex; ribosome; small ribosomal subunit","Translational control","ribosomal protein S6","http://www.ncbi.nlm.nih.gov/gene/?term=6194","6194","105244208","29304","474722",null,null,"P62753","P62754","P62755","A0A8I3NUU7","A0A287BCW5","F6YAF2","GO:0044297; GO:0110165; GO:0005737; GO:0036464; GO:0005829; GO:0022626; GO:0022627; GO:0030425; GO:0005783; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:0048471; GO:0005844; GO:1990904; GO:0005840; GO:0015935","GO:0005515; GO:0019901; GO:0003723; GO:0003735","GO:0006924; GO:0002181; GO:0048821; GO:0000082; GO:0007369; GO:0042593; GO:0022605; GO:0000278; GO:0043066; GO:0001890; GO:0043065; GO:0008284; GO:0042274; GO:0006364; GO:0033077; GO:0002309; GO:0031929; GO:0006412","PTHR11502:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10429|UniProtKB=P62753","P06959"]
["S6 ribosomal protein - phospho","Ser240/Ser244","RPS6","32","rb",null,1,1,1,8,1,8,"# 1166",".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .EGFR., .HIF., .IMUF., .INS., .MTOR., .OP., .OPA., .PI3K., .RTK., .SREME., .TCR.","CCKR signaling map","40S RIBOSOMAL PROTEIN S6","activation-induced cell death of T cells; cytoplasmic translation; erythrocyte development; G1/S transition of mitotic cell cycle; gastrulation; glucose homeostasis; mammalian oogenesis stage; mitotic cell cycle; negative regulation of apoptotic process; placenta development; positive regulation of apoptotic process; positive regulation of cell population proliferation; ribosomal small subunit biogenesis; rRNA processing; T cell differentiation in thymus; T cell proliferation involved in immune response; TOR signaling; translation","protein binding; protein kinase binding; RNA binding; structural constituent of ribosome","cell body; cellular anatomical entity; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; cytosolic ribosome; cytosolic small ribosomal subunit; dendrite; endoplasmic reticulum; membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; polysome; ribonucleoprotein complex; ribosome; small ribosomal subunit","Translational control","ribosomal protein S6","http://www.ncbi.nlm.nih.gov/gene/?term=6194","6194","105244208","29304","474722",null,null,"P62753","P62754","P62755","A0A8I3NUU7","A0A287BCW5","F6YAF2","GO:0044297; GO:0110165; GO:0005737; GO:0036464; GO:0005829; GO:0022626; GO:0022627; GO:0030425; GO:0005783; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:0048471; GO:0005844; GO:1990904; GO:0005840; GO:0015935","GO:0005515; GO:0019901; GO:0003723; GO:0003735","GO:0006924; GO:0002181; GO:0048821; GO:0000082; GO:0007369; GO:0042593; GO:0022605; GO:0000278; GO:0043066; GO:0001890; GO:0043065; GO:0008284; GO:0042274; GO:0006364; GO:0033077; GO:0002309; GO:0031929; GO:0006412","PTHR11502:SF34","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10429|UniProtKB=P62753","P06959"]
["Sav1",null,"SAV1","45","rb",null,6,4,8,8,1,8,"# 1256",".APO., .CCP., .CD., .CP., .CSP., .DEV., .HIPPO., .OP., .OPA., .OT., .ST., .TRASR.",null,"PROTEIN SALVADOR HOMOLOG 1","apoptotic process; cardiac muscle cell proliferation; epithelial cell proliferation; hair follicle development; hippo signaling; intestinal epithelial cell differentiation; keratinocyte apoptotic process; keratinocyte differentiation; lung epithelial cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of epithelial cell proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of fat cell differentiation; positive regulation of keratinocyte apoptotic process; protein stabilization; receptor clustering; regulation of cell population proliferation; regulation of organ growth; regulation of stem cell population maintenance; signal transduction; ventricular septum morphogenesis","beta-1 adrenergic receptor binding; identical protein binding; molecular adaptor activity; protein binding; signaling receptor complex adaptor activity; SMAD binding; type II activin receptor binding","cell-cell junction; cytoplasm; cytosol; dendrite; nucleus; plasma membrane","Hippo signaling","salvador family WW domain containing protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=60485","60485","64010","299116","480319",null,"706424","Q9H4B6","Q8VEB2","A4V8B4","A0A8I3MQ88","A0A286ZHY8","A0A1D5R159","GO:0005911; GO:0005737; GO:0005829; GO:0030425; GO:0005634; GO:0005886","GO:0031697; GO:0042802; GO:0060090; GO:0005515; GO:0030159; GO:0046332; GO:0070699","GO:0006915; GO:0060038; GO:0050673; GO:0001942; GO:0035329; GO:0060575; GO:0097283; GO:0030216; GO:0060487; GO:0060044; GO:0050680; GO:0051091; GO:0045600; GO:1902174; GO:0050821; GO:0043113; GO:0042127; GO:0046620; GO:2000036; GO:0007165; GO:0060412","PTHR47522:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17795|UniProtKB=Q9H4B6"]
["Scribble",null,"SCRIB","240","rb",null,2,4,4,4,6,6,"# 1518",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HIPPO., .IMUF., .MIG., .OP., .OT., .TCR., .TRASR.",null,"PROTEIN SCRIBBLE HOMOLOG","activation of GTPase activity; apoptotic process involved in morphogenesis; astrocyte cell migration; auditory receptor cell morphogenesis; auditory receptor cell stereocilium organization; cell differentiation; cell migration; cell population proliferation; cell-cell adhesion; cochlear nucleus development; establishment of apical/basal cell polarity; establishment of T cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; inner ear receptor cell stereocilium organization; mammary gland duct morphogenesis; morphogenesis of embryonic epithelium; negative regulation of activated T cell proliferation; negative regulation of mitotic cell cycle; neural tube closure; neurotransmitter receptor transport postsynaptic membrane to endosome; neurotransmitter receptor transport, endosome to postsynaptic membrane; polarized epithelial cell differentiation; positive chemotaxis; positive regulation of apoptotic process; positive regulation of receptor recycling; positive regulation of type II interferon production; post-anal tail morphogenesis; protein localization; protein localization to adherens junction; receptor clustering; receptor localization to synapse; regulation of postsynaptic neurotransmitter receptor internalization; synaptic vesicle endocytosis; synaptic vesicle targeting; vesicle-mediated transport in synapse; wound healing","cadherin binding; protein binding","adherens junction; anchoring junction; basolateral plasma membrane; cell junction; cell leading edge; cell projection; cell-cell contact zone; cell-cell junction; cytoplasm; extracellular exosome; extrinsic component of postsynaptic density membrane; glutamatergic synapse; immunological synapse; lamellipodium; membrane; myelin sheath abaxonal region; nucleoplasm; plasma membrane; postsynapse; postsynaptic density; postsynaptic membrane; presynapse; presynaptic membrane; Scrib-APC-beta-catenin complex; synapse","Adhesion","scribble planar cell polarity protein","http://www.ncbi.nlm.nih.gov/gene/?term=23513","23513","105782",null,null,null,null,"Q14160","Q80U72","A0A8I6ABB5","A0A8I3NRW1",null,"A0A1D5QGH4","GO:0005912; GO:0070161; GO:0016323; GO:0030054; GO:0031252; GO:0042995; GO:0044291; GO:0005911; GO:0005737; GO:0070062; GO:0099147; GO:0098978; GO:0001772; GO:0030027; GO:0016020; GO:0035748; GO:0005654; GO:0005886; GO:0098794; GO:0014069; GO:0045211; GO:0098793; GO:0042734; GO:0034750; GO:0045202","GO:0045296; GO:0005515","GO:0090630; GO:0060561; GO:0043615; GO:0002093; GO:0060088; GO:0030154; GO:0016477; GO:0008283; GO:0098609; GO:0021747; GO:0035089; GO:0001768; GO:0045197; GO:0060122; GO:0060603; GO:0016331; GO:0046007; GO:0045930; GO:0001843; GO:0098968; GO:0098887; GO:0030859; GO:0050918; GO:0043065; GO:0001921; GO:0032729; GO:0036342; GO:0008104; GO:0071896; GO:0043113; GO:0097120; GO:0099149; GO:0048488; GO:0016080; GO:0099003; GO:0042060","PTHR23119:SF57","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=30377|UniProtKB=Q14160"]
["Scube2",null,"SCUBE2","88","ms",null,4,4,"n/a","n/a","n/a","n/a","# 2847",".CSP., .DEV., .HHSP., .OPA., .ST.",null,"SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2","signal transduction","calcium ion binding; lipid binding; protein binding","cell surface; extracellular region; extracellular space",null,"signal peptide, CUB domain and EGF like domain containing 2","http://www.ncbi.nlm.nih.gov/gene/?term=57758","57758",null,null,null,null,null,"Q9NQ36","Q9JJS0","A0A0G2JVB2",null,"A0A5G2QEQ6","A0A1D5Q370","GO:0009986; GO:0005576; GO:0005615","GO:0005509; GO:0008289; GO:0005515","GO:0007165","PTHR24046:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=30425|UniProtKB=Q9NQ36"]
["SDS (serine dehydratase)",null,"SDS","35","rb",null,2,1,1,2,2,2,"# 1153",null,null,"L-SERINE DEHYDRATASE/L-THREONINE DEAMINASE","amino acid metabolic process; gluconeogenesis; isoleucine biosynthetic process; lipid metabolic process; L-serine catabolic process; pyruvate biosynthetic process; threonine catabolic process","L-serine ammonia-lyase activity; L-threonine ammonia-lyase activity; lyase activity; protein binding; protein homodimerization activity; pyridoxal phosphate binding","cytoplasm; cytosol; mitochondrion","Carbohydrate biosynthesis / gluconeogenesis","serine dehydratase","http://www.ncbi.nlm.nih.gov/gene/?term=10993","10993","231691","25044",null,null,"713285","P20132","Q8VBT2","P09367",null,null,"A0A1D5RES6","GO:0005737; GO:0005829; GO:0005739","GO:0003941; GO:0004794; GO:0016829; GO:0005515; GO:0042803; GO:0030170","GO:0006520; GO:0006094; GO:0009097; GO:0006629; GO:0006565; GO:0042866; GO:0006567","PTHR48078:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10691|UniProtKB=P20132"]
["Serotonin receptor (5-HT2AR)",null,"HTR2A","55","ms",null,2,2,"n/a","n/a","n/a","n/a","# 0909",".CCP., .CP., .CSP., .DRR., .GPCR., .GPROT., .IMUR., .MAPK., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .VIR.","5HT2 type receptor mediated signaling pathway; Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway","5-HYDROXYTRYPTAMINE RECEPTOR 2A","activation of phospholipase C activity; aging; artery smooth muscle contraction; behavior; behavioral response to cocaine; cell death; cellular calcium ion homeostasis; chemical synaptic transmission; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G protein-coupled serotonin receptor signaling pathway; glycolytic process; memory; negative regulation of potassium ion transport; negative regulation of synaptic transmission, glutamatergic; peptidyl-tyrosine phosphorylation; phosphatidylinositol 3-kinase signaling; phospholipase C-activating G protein-coupled receptor signaling pathway; phospholipase C-activating serotonin receptor signaling pathway; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fat cell differentiation; positive regulation of glycolytic process; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of vasoconstriction; presynaptic modulation of chemical synaptic transmission; protein localization to cytoskeleton; regulation of dopamine secretion; release of sequestered calcium ion into cytosol; response to xenobiotic stimulus; sensory perception of pain; serotonin receptor signaling pathway; signal transduction; sleep; temperature homeostasis; urinary bladder smooth muscle contraction; viral entry into host cell","1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; G protein-coupled receptor activity; G protein-coupled serotonin receptor activity; Gq/11-coupled serotonin receptor activity; identical protein binding; neurotransmitter receptor activity; protein binding; protein-containing complex binding; serotonin binding; virus receptor activity","axon; caveola; cell body fiber; cell projection; cytoplasm; cytoplasmic vesicle; cytosol; dendrite; dendritic shaft; G protein-coupled serotonin receptor complex; glutamatergic synapse; membrane; neuronal cell body; plasma membrane; postsynaptic membrane; presynapse; presynaptic membrane; synapse",null,"5-hydroxytryptamine receptor 2A","http://www.ncbi.nlm.nih.gov/gene/?term=3356","3356","15558","29595",null,null,"613032","P28223","P35363","P14842",null,null,"P50128","GO:0030424; GO:0005901; GO:0070852; GO:0042995; GO:0005737; GO:0031410; GO:0005829; GO:0030425; GO:0043198; GO:0098666; GO:0098978; GO:0016020; GO:0043025; GO:0005886; GO:0045211; GO:0098793; GO:0042734; GO:0045202","GO:0071886; GO:0004930; GO:0004993; GO:0001587; GO:0042802; GO:0030594; GO:0005515; GO:0044877; GO:0051378; GO:0001618","GO:0007202; GO:0007568; GO:0014824; GO:0007610; GO:0048148; GO:0008219; GO:0006874; GO:0007268; GO:0050966; GO:0050965; GO:0007186; GO:0007187; GO:0098664; GO:0006096; GO:0007613; GO:0043267; GO:0051967; GO:0018108; GO:0014065; GO:0007200; GO:0007208; GO:0008284; GO:0007204; GO:0070374; GO:0045600; GO:0045821; GO:0033674; GO:0043406; GO:0050731; GO:0010513; GO:0045907; GO:0099171; GO:0044380; GO:0014059; GO:0051209; GO:0009410; GO:0019233; GO:0007210; GO:0007165; GO:0030431; GO:0001659; GO:0014832; GO:0046718","PTHR24247:SF30","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=5293|UniProtKB=P28223","P04374; P00026"]
["SFPQ",null,"SFPQ","76","rb",null,3,6,"n/a","n/a","n/a","n/a","# 2240",".APO., .CD., .CSP., .DDR., .DREP., .IIR., .IMU., .IMUR., .OP., .OT., .TRASR.",null,"SPLICING FACTOR, PROLINE- AND GLUTAMINE-RICH","activation of innate immune response; alternative mRNA splicing, via spliceosome; cellular response to DNA damage stimulus; DNA recombination; DNA repair; double-strand break repair via homologous recombination; histone H3 deacetylation; immune system process; innate immune response; mRNA processing; negative regulation of circadian rhythm; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of DNA-templated transcription; rhythmic process; RNA splicing","chromatin binding; DNA binding; histone deacetylase binding; nucleic acid binding; protein binding; protein homodimerization activity; RNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; nuclear matrix; nuclear speck; nucleoplasm; nucleus; paraspeckles; RNA polymerase II transcription regulator complex",null,"splicing factor proline and glutamine rich","http://www.ncbi.nlm.nih.gov/gene/?term=6421","6421","71514",null,null,null,null,"P23246","Q8VIJ6","A0A8I6A7U6","A0A8P0PRT5",null,"A0A5F8AUI1","GO:0000785; GO:0005737; GO:0005829; GO:0016363; GO:0016607; GO:0005654; GO:0005634; GO:0042382; GO:0090575","GO:0003682; GO:0003677; GO:0042826; GO:0003676; GO:0005515; GO:0042803; GO:0003723; GO:0000976","GO:0002218; GO:0000380; GO:0006974; GO:0006310; GO:0006281; GO:0000724; GO:0070932; GO:0002376; GO:0045087; GO:0006397; GO:0042754; GO:0045892; GO:0000122; GO:1902177; GO:0045944; GO:0042752; GO:0006355; GO:0048511; GO:0008380","PTHR23189:SF51","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10774|UniProtKB=P23246"]
["SFRP2",null,"SFRP2","33","rb",null,1.1000000000000001,1.1000000000000001,8,8,8,8,"# 1404",".ANG., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .DRR., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TRASR., .WNT.","Wnt signaling pathway","SECRETED FRIZZLED-RELATED PROTEIN 2","anatomical structure development; anterior/posterior pattern specification; apoptotic process; BMP signaling pathway; branching involved in blood vessel morphogenesis; canonical Wnt signaling pathway; cardiac left ventricle morphogenesis; cardiac muscle cell apoptotic process; cartilage development; cell differentiation; cell-cell signaling; cellular response to extracellular stimulus; cellular response to X-ray; chondrocyte development; collagen fibril organization; convergent extension involved in axis elongation; development of primary male sexual characteristics; digestive tract morphogenesis; embryonic digit morphogenesis; hematopoietic stem cell proliferation; male gonad development; mesodermal cell fate specification; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of dermatome development; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of JUN kinase activity; negative regulation of mesodermal cell fate specification; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of planar cell polarity pathway involved in axis elongation; negative regulation of Wnt signaling pathway; neural tube closure; neural tube development; outflow tract morphogenesis; planar cell polarity pathway involved in axis elongation; planar cell polarity pathway involved in neural tube closure; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; positive regulation of cell adhesion mediated by integrin; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of endopeptidase activity; positive regulation of fat cell differentiation; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription by RNA polymerase II; post-anal tail morphogenesis; regulation of apoptotic process; regulation of cell population proliferation; regulation of developmental process; regulation of establishment of planar polarity; regulation of midbrain dopaminergic neuron differentiation; regulation of neuron projection development; regulation of stem cell division; regulation of Wnt signaling pathway; response to nutrient; response to xenobiotic stimulus; sclerotome development; somitogenesis; stem cell fate specification; Wnt signaling pathway; Wnt signaling pathway involved in somitogenesis","endopeptidase activator activity; enzyme activator activity; fibronectin binding; integrin binding; receptor ligand activity; Wnt-protein binding","collagen-containing extracellular matrix; extracellular region; extracellular space","Wnt signaling","secreted frizzled related protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=6423","6423","20319","310552","475471","100516027","699915","Q96HF1","P97299","B1WBV2","Q863H1","F1RX31","G7MS58","GO:0062023; GO:0005576; GO:0005615","GO:0061133; GO:0008047; GO:0001968; GO:0005178; GO:0048018; GO:0017147","GO:0048856; GO:0009952; GO:0006915; GO:0030509; GO:0001569; GO:0060070; GO:0003214; GO:0010659; GO:0051216; GO:0030154; GO:0007267; GO:0031668; GO:0071481; GO:0002063; GO:0030199; GO:0060028; GO:0046546; GO:0048546; GO:0042733; GO:0071425; GO:0008584; GO:0007501; GO:0030514; GO:0090090; GO:0010667; GO:0030308; GO:0030336; GO:0008285; GO:0043154; GO:0061185; GO:0045892; GO:0050680; GO:0010719; GO:1902042; GO:0010629; GO:1902230; GO:0043508; GO:0042662; GO:0050732; GO:2000041; GO:0030178; GO:0001843; GO:0021915; GO:0003151; GO:0003402; GO:0090179; GO:0045766; GO:0043065; GO:0090263; GO:0033630; GO:0030307; GO:0008284; GO:0010950; GO:0045600; GO:0045669; GO:0033138; GO:0045944; GO:0036342; GO:0042981; GO:0042127; GO:0050793; GO:0090175; GO:1904956; GO:0010975; GO:2000035; GO:0030111; GO:0007584; GO:0009410; GO:0061056; GO:0001756; GO:0048866; GO:0016055; GO:0090244","PTHR11309:SF45","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10777|UniProtKB=Q96HF1","P00057"]
["SGK1",null,"SGK1","60-45","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2385",".APO., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DMTOR., .FOXO., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .ST., .TRASR.",null,"SERINE/THREONINE-PROTEIN KINASE SGK1","apoptotic process; cellular response to aldosterone; cellular response to DNA damage stimulus; intracellular signal transduction; long-term memory; neuron projection morphogenesis; peptidyl-serine phosphorylation; phosphorylation; positive regulation of transporter activity; protein phosphorylation; regulation of apoptotic process; regulation of blood pressure; regulation of catalytic activity; regulation of cell growth; regulation of cell migration; regulation of cell population proliferation; regulation of DNA-binding transcription factor activity; regulation of gastric acid secretion; regulation of signal transduction by p53 class mediator; renal sodium ion absorption; sodium ion transport","ATP binding; calcium channel regulator activity; chloride channel regulator activity; kinase activity; nucleotide binding; potassium channel regulator activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; sodium channel regulator activity; transferase activity","cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrion; nuclear speck; nucleoplasm; nucleus; plasma membrane",null,"serum/glucocorticoid regulated kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=6446","6446","20393","29517","403647","100625739","713082","O00141","Q9WVC6","A0A0G2JVM7","A0A8I3MU12","A0A286ZMR5","A0A5K1VLQ6","GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0005739; GO:0016607; GO:0005654; GO:0005634; GO:0005886","GO:0005524; GO:0005246; GO:0017081; GO:0016301; GO:0000166; GO:0015459; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0017080; GO:0016740","GO:0006915; GO:1904045; GO:0006974; GO:0035556; GO:0007616; GO:0048812; GO:0018105; GO:0016310; GO:0032411; GO:0006468; GO:0042981; GO:0008217; GO:0050790; GO:0001558; GO:0030334; GO:0042127; GO:0051090; GO:0060453; GO:1901796; GO:0070294; GO:0006814","PTHR24356:SF300","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10810|UniProtKB=O00141"]
["SGK1 - phospho","Ser78","SGK1","54","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2387",".APO., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DMTOR., .FOXO., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .ST., .TRASR.",null,"SERINE/THREONINE-PROTEIN KINASE SGK1","apoptotic process; cellular response to aldosterone; cellular response to DNA damage stimulus; intracellular signal transduction; long-term memory; neuron projection morphogenesis; peptidyl-serine phosphorylation; phosphorylation; positive regulation of transporter activity; protein phosphorylation; regulation of apoptotic process; regulation of blood pressure; regulation of catalytic activity; regulation of cell growth; regulation of cell migration; regulation of cell population proliferation; regulation of DNA-binding transcription factor activity; regulation of gastric acid secretion; regulation of signal transduction by p53 class mediator; renal sodium ion absorption; sodium ion transport","ATP binding; calcium channel regulator activity; chloride channel regulator activity; kinase activity; nucleotide binding; potassium channel regulator activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; sodium channel regulator activity; transferase activity","cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrion; nuclear speck; nucleoplasm; nucleus; plasma membrane",null,"serum/glucocorticoid regulated kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=6446","6446","20393","29517","403647","100625739","713082","O00141","Q9WVC6","A0A0G2JVM7","A0A8I3MU12","A0A286ZMR5","A0A5K1VLQ6","GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0005739; GO:0016607; GO:0005654; GO:0005634; GO:0005886","GO:0005524; GO:0005246; GO:0017081; GO:0016301; GO:0000166; GO:0015459; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004712; GO:0017080; GO:0016740","GO:0006915; GO:1904045; GO:0006974; GO:0035556; GO:0007616; GO:0048812; GO:0018105; GO:0016310; GO:0032411; GO:0006468; GO:0042981; GO:0008217; GO:0050790; GO:0001558; GO:0030334; GO:0042127; GO:0051090; GO:0060453; GO:1901796; GO:0070294; GO:0006814","PTHR24356:SF300","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10810|UniProtKB=O00141"]
["SGK3",null,"SGK3","61","rb",null,1,2,"n/a","n/a","n/a","n/a","# 2386",".APO., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .FOXO., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.",null,"SERINE/THREONINE-PROTEIN KINASE SGK3","intracellular signal transduction; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation; regulation of cell growth; regulation of cell migration; regulation of cell population proliferation; regulation of DNA-binding transcription factor activity","ATP binding; calcium channel regulator activity; chloride channel regulator activity; kinase activity; nucleotide binding; phosphatidylinositol binding; potassium channel regulator activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; sodium channel regulator activity; transferase activity","cytoplasmic vesicle; cytosol; early endosome; endosome; recycling endosome",null,"serum/glucocorticoid regulated kinase family member 3","http://www.ncbi.nlm.nih.gov/gene/?term=100533105","100533105","170755",null,null,null,null,"Q96BR1","Q9ERE3","M0R582","A0A8I3P778","A0A286ZT89","F7H8X9","GO:0031410; GO:0005829; GO:0005769; GO:0005768; GO:0055037","GO:0005524; GO:0005246; GO:0017081; GO:0016301; GO:0000166; GO:0035091; GO:0015459; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0017080; GO:0016740","GO:0035556; GO:2001240; GO:0018105; GO:0016310; GO:0006468; GO:0001558; GO:0030334; GO:0042127; GO:0051090","PTHR24356:SF121","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10812|UniProtKB=Q96BR1"]
["SGK3 - phospho","Thr320","SGK3","62","rb",null,2,6,"n/a","n/a","n/a","n/a","# 2388",".APO., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .FOXO., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.",null,"SERINE/THREONINE-PROTEIN KINASE SGK3","intracellular signal transduction; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation; regulation of cell growth; regulation of cell migration; regulation of cell population proliferation; regulation of DNA-binding transcription factor activity","ATP binding; calcium channel regulator activity; chloride channel regulator activity; kinase activity; nucleotide binding; phosphatidylinositol binding; potassium channel regulator activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; sodium channel regulator activity; transferase activity","cytoplasmic vesicle; cytosol; early endosome; endosome; recycling endosome",null,"serum/glucocorticoid regulated kinase family member 3","http://www.ncbi.nlm.nih.gov/gene/?term=100533105","100533105","170755",null,null,null,null,"Q96BR1","Q9ERE3","M0R582","A0A8I3P778","A0A286ZT89","F7H8X9","GO:0031410; GO:0005829; GO:0005769; GO:0005768; GO:0055037","GO:0005524; GO:0005246; GO:0017081; GO:0016301; GO:0000166; GO:0035091; GO:0015459; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0017080; GO:0016740","GO:0035556; GO:2001240; GO:0018105; GO:0016310; GO:0006468; GO:0001558; GO:0030334; GO:0042127; GO:0051090","PTHR24356:SF121","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10812|UniProtKB=Q96BR1"]
["Shh",null,"SHH","45, 19","rb",null,6,4,"n/a","n/a","n/a","n/a","# 1438",".ANG., .APO., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .HHSP., .IMUF., .MIG., .OP., .OPA., .OT., .PLAT., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .WNT.","Hedgehog signaling pathway","SONIC HEDGEHOG PROTEIN","alpha-beta T cell differentiation; alpha-tubulin acetylation; anatomical structure development; anatomical structure formation involved in morphogenesis; androgen metabolic process; angiogenesis; animal organ development; animal organ formation; anterior/posterior pattern specification; apoptotic signaling pathway; artery development; astrocyte differentiation; axon guidance; Bergmann glial cell differentiation; blood coagulation; branching involved in blood vessel morphogenesis; branching involved in prostate gland morphogenesis; branching involved in salivary gland morphogenesis; branching involved in ureteric bud morphogenesis; branching morphogenesis of an epithelial tube; bud outgrowth involved in lung branching; camera-type eye development; canonical Wnt signaling pathway; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; cell development; cell fate commitment; cell fate specification; cell migration; cell population proliferation; cell proliferation in external granule layer; cell-cell signaling; cellular response to lithium ion; central nervous system development; cerebellar granule cell precursor proliferation; determination of left/right asymmetry in lateral mesoderm; determination of left/right symmetry; developmental growth; digestive tract morphogenesis; dopaminergic neuron differentiation; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; ectoderm development; embryonic digestive tract morphogenesis; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic morphogenesis; embryonic organ development; embryonic pattern specification; embryonic skeletal system development; endocytosis; epithelial cell proliferation; epithelial cell proliferation involved in prostate gland development; epithelial cell proliferation involved in salivary gland morphogenesis; epithelial tube branching involved in lung morphogenesis; epithelial-mesenchymal cell signaling; epithelial-mesenchymal signaling involved in prostate gland development; establishment of epithelial cell polarity; forebrain development; forebrain regionalization; formation of anatomical boundary; gene expression; hair follicle development; hair follicle morphogenesis; heart development; heart looping; hindbrain development; hindgut morphogenesis; inner ear development; intein-mediated protein splicing; intermediate filament organization; kidney development; left lung development; limb bud formation; limb development; lung development; lung epithelium development; lung lobe morphogenesis; lung morphogenesis; lung-associated mesenchyme development; lymphoid progenitor cell differentiation; male genitalia development; mesenchymal cell apoptotic process; mesenchymal cell proliferation; mesenchymal cell proliferation involved in lung development; mesenchymal smoothened signaling pathway involved in prostate gland development; metanephric collecting duct development; metanephric mesenchymal cell proliferation involved in metanephros development; metanephros development; midbrain development; myoblast differentiation; myotube differentiation; negative regulation of alpha-beta T cell differentiation; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cell differentiation; negative regulation of cell migration; negative regulation of cholesterol efflux; negative regulation of dopaminergic neuron differentiation; negative regulation of gene expression; negative regulation of kidney smooth muscle cell differentiation; negative regulation of mesenchymal cell apoptotic process; negative regulation of neuron differentiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein catabolic process; negative regulation of T cell differentiation in thymus; negative regulation of T cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription elongation by RNA polymerase II; negative regulation of ureter smooth muscle cell differentiation; negative regulation of Wnt signaling pathway; negative thymic T cell selection; neural crest cell migration; neuroblast proliferation; neuron differentiation; neuron fate commitment; odontogenesis; odontogenesis of dentin-containing tooth; oligodendrocyte development; oligodendrocyte differentiation; osteoblast development; pancreas development; pattern specification process; polarity specification of anterior/posterior axis; positive regulation of alpha-beta T cell differentiation; positive regulation of astrocyte differentiation; positive regulation of cell division; positive regulation of cell population proliferation; positive regulation of cerebellar granule cell precursor proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of gene expression; positive regulation of hh target transcription factor activity; positive regulation of immature T cell proliferation in thymus; positive regulation of kidney smooth muscle cell differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of mesenchymal cell proliferation involved in ureter development; positive regulation of neuroblast proliferation; positive regulation of oligodendrocyte differentiation; positive regulation of protein import into nucleus; positive regulation of sclerotome development; positive regulation of skeletal muscle cell proliferation; positive regulation of skeletal muscle tissue development; positive regulation of smoothened signaling pathway; positive regulation of striated muscle cell differentiation; positive regulation of T cell differentiation in thymus; positive regulation of transcription by RNA polymerase II; positive regulation of ureter smooth muscle cell differentiation; positive regulation of Wnt signaling pathway; positive thymic T cell selection; primary prostatic bud elongation; prostate epithelial cord elongation; prostate gland development; protein autoprocessing; protein import into nucleus; protein localization to nucleus; proteolysis; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of epithelial cell proliferation involved in prostate gland development; regulation of gene expression; regulation of glial cell proliferation; regulation of mesenchymal cell proliferation involved in prostate gland development; regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; regulation of odontogenesis; regulation of prostatic bud formation; regulation of protein localization to nucleus; regulation of proteolysis; regulation of stem cell proliferation; respiratory tube development; right lung development; roof of mouth development; salivary gland cavitation; self proteolysis; skeletal muscle cell proliferation; skeletal muscle fiber differentiation; skeletal muscle tissue development; skin development; smooth muscle tissue development; smoothened signaling pathway; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; somite development; spinal cord dorsal/ventral patterning; spinal cord motor neuron differentiation; stem cell development; stem cell proliferation; striated muscle cell differentiation; striated muscle tissue development; system development; T cell differentiation in thymus; T cell proliferation; telencephalon regionalization; thalamus development; thymus development; thyroid gland development; trachea development; trachea morphogenesis; tracheoesophageal septum formation; trunk neural crest cell migration; vasculature development; vasculogenesis; ventral midline development","calcium ion binding; cholesterol-protein transferase activity; endopeptidase activity; glycosaminoglycan binding; hydrolase activity; laminin-1 binding; metal ion binding; morphogen activity; patched binding; peptidase activity; protein binding; transferase activity; zinc ion binding","cell surface; collagen-containing extracellular matrix; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; membrane; membrane raft; plasma membrane","Development","sonic hedgehog signaling molecule","http://www.ncbi.nlm.nih.gov/gene/?term=6469","6469","20423",null,"608860",null,null,"Q15465","Q62226","G3V6T0","A0A8I3NQ51","F1SHU9",null,"GO:0009986; GO:0062023; GO:0005829; GO:0005783; GO:0005788; GO:0005789; GO:0031012; GO:0005576; GO:0005615; GO:0005794; GO:0000139; GO:0016020; GO:0045121; GO:0005886","GO:0005509; GO:0140853; GO:0004175; GO:0005539; GO:0016787; GO:0043237; GO:0046872; GO:0016015; GO:0005113; GO:0008233; GO:0005515; GO:0016740; GO:0008270","GO:0046632; GO:0071929; GO:0048856; GO:0048646; GO:0008209; GO:0001525; GO:0048513; GO:0048645; GO:0009952; GO:0097190; GO:0060840; GO:0048708; GO:0007411; GO:0060020; GO:0007596; GO:0001569; GO:0060442; GO:0060445; GO:0001658; GO:0048754; GO:0060447; GO:0043010; GO:0060070; GO:0043369; GO:0048468; GO:0045165; GO:0001708; GO:0016477; GO:0008283; GO:0021924; GO:0007267; GO:0071285; GO:0007417; GO:0021930; GO:0003140; GO:0007368; GO:0048589; GO:0048546; GO:0071542; GO:0021904; GO:0009953; GO:0007398; GO:0048557; GO:0042733; GO:0048617; GO:0035115; GO:0035116; GO:0030326; GO:0048598; GO:0048568; GO:0009880; GO:0048706; GO:0006897; GO:0050673; GO:0060767; GO:0060664; GO:0060441; GO:0060684; GO:0060738; GO:0090162; GO:0030900; GO:0021871; GO:0048859; GO:0010467; GO:0001942; GO:0031069; GO:0007507; GO:0001947; GO:0030902; GO:0007442; GO:0048839; GO:0016539; GO:0045109; GO:0001822; GO:0060459; GO:0060174; GO:0060173; GO:0030324; GO:0060428; GO:0060463; GO:0060425; GO:0060484; GO:0002320; GO:0030539; GO:0097152; GO:0010463; GO:0060916; GO:0060783; GO:0072205; GO:0072136; GO:0001656; GO:0030901; GO:0045445; GO:0014902; GO:0046639; GO:0043066; GO:0090090; GO:0045596; GO:0030336; GO:0090370; GO:1904339; GO:0010629; GO:2000357; GO:2001054; GO:0045665; GO:0032435; GO:0042177; GO:0033085; GO:0042130; GO:0000122; GO:0034244; GO:2000062; GO:0030178; GO:0045060; GO:0001755; GO:0007405; GO:0030182; GO:0048663; GO:0042476; GO:0042475; GO:0014003; GO:0048709; GO:0002076; GO:0031016; GO:0007389; GO:0009949; GO:0046638; GO:0048711; GO:0051781; GO:0008284; GO:0021940; GO:0045893; GO:0050679; GO:0060769; GO:0010628; GO:0007228; GO:0033092; GO:2000358; GO:0002053; GO:2000729; GO:0002052; GO:0048714; GO:0042307; GO:0061189; GO:0014858; GO:0048643; GO:0045880; GO:0051155; GO:0033089; GO:0045944; GO:2000063; GO:0030177; GO:0045059; GO:0060516; GO:0060523; GO:0030850; GO:0016540; GO:0006606; GO:0034504; GO:0006508; GO:0042127; GO:0006355; GO:0060768; GO:0010468; GO:0060251; GO:0060782; GO:1900175; GO:0042481; GO:0060685; GO:1900180; GO:0030162; GO:0072091; GO:0030323; GO:0060458; GO:0060021; GO:0060662; GO:0097264; GO:0014856; GO:0098528; GO:0007519; GO:0043588; GO:0048745; GO:0007224; GO:0021938; GO:0061053; GO:0021513; GO:0021522; GO:0048864; GO:0072089; GO:0051146; GO:0014706; GO:0048731; GO:0033077; GO:0042098; GO:0021978; GO:0021794; GO:0048538; GO:0030878; GO:0060438; GO:0060439; GO:1905327; GO:0036484; GO:0001944; GO:0001570; GO:0007418","PTHR11889:SF36","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10848|UniProtKB=Q15465","P00025"]
["Shh (c-terminal)",null,"SHH","50","gt",null,1,6,"n/a","n/a","n/a","n/a","# 2866",".ANG., .APO., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .HHSP., .IMUF., .MIG., .OP., .OPA., .OT., .PLAT., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .WNT.","Hedgehog signaling pathway","SONIC HEDGEHOG PROTEIN","alpha-beta T cell differentiation; alpha-tubulin acetylation; anatomical structure development; anatomical structure formation involved in morphogenesis; androgen metabolic process; angiogenesis; animal organ development; animal organ formation; anterior/posterior pattern specification; apoptotic signaling pathway; artery development; astrocyte differentiation; axon guidance; Bergmann glial cell differentiation; blood coagulation; branching involved in blood vessel morphogenesis; branching involved in prostate gland morphogenesis; branching involved in salivary gland morphogenesis; branching involved in ureteric bud morphogenesis; branching morphogenesis of an epithelial tube; bud outgrowth involved in lung branching; camera-type eye development; canonical Wnt signaling pathway; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; cell development; cell fate commitment; cell fate specification; cell migration; cell population proliferation; cell proliferation in external granule layer; cell-cell signaling; cellular response to lithium ion; central nervous system development; cerebellar granule cell precursor proliferation; determination of left/right asymmetry in lateral mesoderm; determination of left/right symmetry; developmental growth; digestive tract morphogenesis; dopaminergic neuron differentiation; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; ectoderm development; embryonic digestive tract morphogenesis; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic morphogenesis; embryonic organ development; embryonic pattern specification; embryonic skeletal system development; endocytosis; epithelial cell proliferation; epithelial cell proliferation involved in prostate gland development; epithelial cell proliferation involved in salivary gland morphogenesis; epithelial tube branching involved in lung morphogenesis; epithelial-mesenchymal cell signaling; epithelial-mesenchymal signaling involved in prostate gland development; establishment of epithelial cell polarity; forebrain development; forebrain regionalization; formation of anatomical boundary; gene expression; hair follicle development; hair follicle morphogenesis; heart development; heart looping; hindbrain development; hindgut morphogenesis; inner ear development; intein-mediated protein splicing; intermediate filament organization; kidney development; left lung development; limb bud formation; limb development; lung development; lung epithelium development; lung lobe morphogenesis; lung morphogenesis; lung-associated mesenchyme development; lymphoid progenitor cell differentiation; male genitalia development; mesenchymal cell apoptotic process; mesenchymal cell proliferation; mesenchymal cell proliferation involved in lung development; mesenchymal smoothened signaling pathway involved in prostate gland development; metanephric collecting duct development; metanephric mesenchymal cell proliferation involved in metanephros development; metanephros development; midbrain development; myoblast differentiation; myotube differentiation; negative regulation of alpha-beta T cell differentiation; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cell differentiation; negative regulation of cell migration; negative regulation of cholesterol efflux; negative regulation of dopaminergic neuron differentiation; negative regulation of gene expression; negative regulation of kidney smooth muscle cell differentiation; negative regulation of mesenchymal cell apoptotic process; negative regulation of neuron differentiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein catabolic process; negative regulation of T cell differentiation in thymus; negative regulation of T cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription elongation by RNA polymerase II; negative regulation of ureter smooth muscle cell differentiation; negative regulation of Wnt signaling pathway; negative thymic T cell selection; neural crest cell migration; neuroblast proliferation; neuron differentiation; neuron fate commitment; odontogenesis; odontogenesis of dentin-containing tooth; oligodendrocyte development; oligodendrocyte differentiation; osteoblast development; pancreas development; pattern specification process; polarity specification of anterior/posterior axis; positive regulation of alpha-beta T cell differentiation; positive regulation of astrocyte differentiation; positive regulation of cell division; positive regulation of cell population proliferation; positive regulation of cerebellar granule cell precursor proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of gene expression; positive regulation of hh target transcription factor activity; positive regulation of immature T cell proliferation in thymus; positive regulation of kidney smooth muscle cell differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of mesenchymal cell proliferation involved in ureter development; positive regulation of neuroblast proliferation; positive regulation of oligodendrocyte differentiation; positive regulation of protein import into nucleus; positive regulation of sclerotome development; positive regulation of skeletal muscle cell proliferation; positive regulation of skeletal muscle tissue development; positive regulation of smoothened signaling pathway; positive regulation of striated muscle cell differentiation; positive regulation of T cell differentiation in thymus; positive regulation of transcription by RNA polymerase II; positive regulation of ureter smooth muscle cell differentiation; positive regulation of Wnt signaling pathway; positive thymic T cell selection; primary prostatic bud elongation; prostate epithelial cord elongation; prostate gland development; protein autoprocessing; protein import into nucleus; protein localization to nucleus; proteolysis; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of epithelial cell proliferation involved in prostate gland development; regulation of gene expression; regulation of glial cell proliferation; regulation of mesenchymal cell proliferation involved in prostate gland development; regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; regulation of odontogenesis; regulation of prostatic bud formation; regulation of protein localization to nucleus; regulation of proteolysis; regulation of stem cell proliferation; respiratory tube development; right lung development; roof of mouth development; salivary gland cavitation; self proteolysis; skeletal muscle cell proliferation; skeletal muscle fiber differentiation; skeletal muscle tissue development; skin development; smooth muscle tissue development; smoothened signaling pathway; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; somite development; spinal cord dorsal/ventral patterning; spinal cord motor neuron differentiation; stem cell development; stem cell proliferation; striated muscle cell differentiation; striated muscle tissue development; system development; T cell differentiation in thymus; T cell proliferation; telencephalon regionalization; thalamus development; thymus development; thyroid gland development; trachea development; trachea morphogenesis; tracheoesophageal septum formation; trunk neural crest cell migration; vasculature development; vasculogenesis; ventral midline development","calcium ion binding; cholesterol-protein transferase activity; endopeptidase activity; glycosaminoglycan binding; hydrolase activity; laminin-1 binding; metal ion binding; morphogen activity; patched binding; peptidase activity; protein binding; transferase activity; zinc ion binding","cell surface; collagen-containing extracellular matrix; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; membrane; membrane raft; plasma membrane","Development","sonic hedgehog signaling molecule","http://www.ncbi.nlm.nih.gov/gene/?term=6469","6469","20423",null,"608860",null,null,"Q15465","Q62226","G3V6T0","A0A8I3NQ51","F1SHU9",null,"GO:0009986; GO:0062023; GO:0005829; GO:0005783; GO:0005788; GO:0005789; GO:0031012; GO:0005576; GO:0005615; GO:0005794; GO:0000139; GO:0016020; GO:0045121; GO:0005886","GO:0005509; GO:0140853; GO:0004175; GO:0005539; GO:0016787; GO:0043237; GO:0046872; GO:0016015; GO:0005113; GO:0008233; GO:0005515; GO:0016740; GO:0008270","GO:0046632; GO:0071929; GO:0048856; GO:0048646; GO:0008209; GO:0001525; GO:0048513; GO:0048645; GO:0009952; GO:0097190; GO:0060840; GO:0048708; GO:0007411; GO:0060020; GO:0007596; GO:0001569; GO:0060442; GO:0060445; GO:0001658; GO:0048754; GO:0060447; GO:0043010; GO:0060070; GO:0043369; GO:0048468; GO:0045165; GO:0001708; GO:0016477; GO:0008283; GO:0021924; GO:0007267; GO:0071285; GO:0007417; GO:0021930; GO:0003140; GO:0007368; GO:0048589; GO:0048546; GO:0071542; GO:0021904; GO:0009953; GO:0007398; GO:0048557; GO:0042733; GO:0048617; GO:0035115; GO:0035116; GO:0030326; GO:0048598; GO:0048568; GO:0009880; GO:0048706; GO:0006897; GO:0050673; GO:0060767; GO:0060664; GO:0060441; GO:0060684; GO:0060738; GO:0090162; GO:0030900; GO:0021871; GO:0048859; GO:0010467; GO:0001942; GO:0031069; GO:0007507; GO:0001947; GO:0030902; GO:0007442; GO:0048839; GO:0016539; GO:0045109; GO:0001822; GO:0060459; GO:0060174; GO:0060173; GO:0030324; GO:0060428; GO:0060463; GO:0060425; GO:0060484; GO:0002320; GO:0030539; GO:0097152; GO:0010463; GO:0060916; GO:0060783; GO:0072205; GO:0072136; GO:0001656; GO:0030901; GO:0045445; GO:0014902; GO:0046639; GO:0043066; GO:0090090; GO:0045596; GO:0030336; GO:0090370; GO:1904339; GO:0010629; GO:2000357; GO:2001054; GO:0045665; GO:0032435; GO:0042177; GO:0033085; GO:0042130; GO:0000122; GO:0034244; GO:2000062; GO:0030178; GO:0045060; GO:0001755; GO:0007405; GO:0030182; GO:0048663; GO:0042476; GO:0042475; GO:0014003; GO:0048709; GO:0002076; GO:0031016; GO:0007389; GO:0009949; GO:0046638; GO:0048711; GO:0051781; GO:0008284; GO:0021940; GO:0045893; GO:0050679; GO:0060769; GO:0010628; GO:0007228; GO:0033092; GO:2000358; GO:0002053; GO:2000729; GO:0002052; GO:0048714; GO:0042307; GO:0061189; GO:0014858; GO:0048643; GO:0045880; GO:0051155; GO:0033089; GO:0045944; GO:2000063; GO:0030177; GO:0045059; GO:0060516; GO:0060523; GO:0030850; GO:0016540; GO:0006606; GO:0034504; GO:0006508; GO:0042127; GO:0006355; GO:0060768; GO:0010468; GO:0060251; GO:0060782; GO:1900175; GO:0042481; GO:0060685; GO:1900180; GO:0030162; GO:0072091; GO:0030323; GO:0060458; GO:0060021; GO:0060662; GO:0097264; GO:0014856; GO:0098528; GO:0007519; GO:0043588; GO:0048745; GO:0007224; GO:0021938; GO:0061053; GO:0021513; GO:0021522; GO:0048864; GO:0072089; GO:0051146; GO:0014706; GO:0048731; GO:0033077; GO:0042098; GO:0021978; GO:0021794; GO:0048538; GO:0030878; GO:0060438; GO:0060439; GO:1905327; GO:0036484; GO:0001944; GO:0001570; GO:0007418","PTHR11889:SF36","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=10848|UniProtKB=Q15465","P00025"]
["SHIP1",null,"INPP5D","145","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0234",".APO., .BCR., .CD., .CSP., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .ST., .TCR., .TRASR.",null,"PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 1","apoptotic process; determination of adult lifespan; immune system process; immunoglobulin mediated immune response; intracellular signal transduction; lipid metabolic process; negative regulation of B cell activation; negative regulation of B cell proliferation; negative regulation of bone resorption; negative regulation of granulocyte differentiation; negative regulation of immune response; negative regulation of interleukin-6 production; negative regulation of monocyte differentiation; negative regulation of neutrophil differentiation; negative regulation of osteoclast differentiation; negative regulation of signal transduction; organophosphate metabolic process; phosphate-containing compound metabolic process; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; positive regulation of apoptotic process; positive regulation of B cell differentiation; positive regulation of erythrocyte differentiation; positive regulation of lymphocyte differentiation; regulation of immune response; regulation of signal transduction; signal transduction; T cell receptor signaling pathway","catalytic activity; hydrolase activity; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity; phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein binding; SH3 domain binding","cytoplasm; cytoskeleton; cytosol; membrane; membrane raft; plasma membrane",null,"inositol polyphosphate-5-phosphatase D","http://www.ncbi.nlm.nih.gov/gene/?term=3635","3635","16331",null,null,null,null,"Q92835","Q9ES52","F1M981","A0A8I3PAP4","A0A287ABR0","A0A5F7ZWB0","GO:0005737; GO:0005856; GO:0005829; GO:0016020; GO:0045121; GO:0005886","GO:0003824; GO:0016787; GO:0052659; GO:0052658; GO:0004445; GO:0016791; GO:0016314; GO:0034485; GO:0004439; GO:0005515; GO:0017124","GO:0006915; GO:0008340; GO:0002376; GO:0016064; GO:0035556; GO:0006629; GO:0050869; GO:0030889; GO:0045779; GO:0030853; GO:0050777; GO:0032715; GO:0045656; GO:0045659; GO:0045671; GO:0009968; GO:0019637; GO:0006796; GO:0006661; GO:0046856; GO:0043065; GO:0045579; GO:0045648; GO:0045621; GO:0050776; GO:0009966; GO:0007165; GO:0050852","PTHR46051:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6079|UniProtKB=Q92835"]
["SHP-2",null,"PTPN11","68","rb",null,1,1,1,1,1,1.1000000000000001,"# 0239",".ANG., .CANCER., .CCKR., .CCP., .CCY., .CD., .CML., .CSP., .DDR., .EGFR., .FGFR., .IMUF., .INFG., .INFM., .INS., .INT., .MAPK., .OP., .OPA., .OT., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TRASR.","CCKR signaling map; FGF signaling pathway; Interferon-gamma signaling pathway; Angiogenesis","TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11","abortive mitotic cell cycle; atrioventricular canal development; axonogenesis; Bergmann glial cell differentiation; brain development; cellular response to epidermal growth factor stimulus; cellular response to organic substance; cerebellar cortex formation; cytokine-mediated signaling pathway; dephosphorylation; DNA damage checkpoint signaling; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB signaling pathway; face morphogenesis; fibroblast growth factor receptor signaling pathway; genitalia development; glucose homeostasis; heart development; homeostasis of number of cells within a tissue; hormone metabolic process; hormone-mediated signaling pathway; inner ear development; integrin-mediated signaling pathway; intestinal epithelial cell migration; lipid metabolic process; megakaryocyte development; microvillus organization; multicellular organism growth; multicellular organismal reproductive process; negative regulation of cell adhesion mediated by integrin; negative regulation of chondrocyte differentiation; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of hormone secretion; negative regulation of insulin secretion; neurotrophin TRK receptor signaling pathway; organ growth; peptidyl-tyrosine dephosphorylation; platelet formation; platelet-derived growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of glucose import; positive regulation of hormone secretion; positive regulation of insulin receptor signaling pathway; positive regulation of interferon-beta production; positive regulation of interleukin-6 production; positive regulation of mitotic cell cycle; positive regulation of ossification; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of signal transduction; positive regulation of tumor necrosis factor production; protein dephosphorylation; regulation of cell adhesion mediated by integrin; regulation of MAPK cascade; regulation of protein export from nucleus; regulation of protein-containing complex assembly; regulation of type I interferon-mediated signaling pathway; signal transduction; T cell costimulation; triglyceride metabolic process","cadherin binding; cell adhesion molecule binding; hydrolase activity; insulin receptor binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phosphatase activity; phosphoprotein phosphatase activity; phosphotyrosine residue binding; protein binding; protein kinase binding; protein tyrosine kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; signaling receptor complex adaptor activity","cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex","Tyrosine phosphatase","protein tyrosine phosphatase non-receptor type 11","http://www.ncbi.nlm.nih.gov/gene/?term=5781","5781","19247",null,"477488",null,"712044","Q06124","P35235","A0A8I6GI01","A0A4D6PF96","A0A287AQB6","H9FXT1","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0032991","GO:0045296; GO:0050839; GO:0016787; GO:0005158; GO:0004726; GO:0051428; GO:0016791; GO:0004721; GO:0001784; GO:0005515; GO:0019901; GO:1990782; GO:0004725; GO:0030971; GO:0030159","GO:0033277; GO:0036302; GO:0007409; GO:0060020; GO:0007420; GO:0071364; GO:0071310; GO:0021697; GO:0019221; GO:0016311; GO:0000077; GO:0048013; GO:0007173; GO:0038127; GO:0060325; GO:0008543; GO:0048806; GO:0042593; GO:0007507; GO:0048873; GO:0042445; GO:0009755; GO:0048839; GO:0007229; GO:0061582; GO:0006629; GO:0035855; GO:0032528; GO:0035264; GO:0048609; GO:0033629; GO:0032331; GO:0051463; GO:0060125; GO:0046888; GO:0046676; GO:0048011; GO:0035265; GO:0035335; GO:0030220; GO:0048008; GO:0070374; GO:0046326; GO:0046887; GO:0046628; GO:0032728; GO:0032755; GO:0045931; GO:0045778; GO:0050731; GO:0009967; GO:0032760; GO:0006470; GO:0033628; GO:0043408; GO:0046825; GO:0043254; GO:0060338; GO:0007165; GO:0031295; GO:0006641","PTHR46559:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9644|UniProtKB=Q06124","P06959; P00021; P00035; P00005"]
["SHP-2 - phospho","Tyr542","PTPN11","72","rb",null,7,1,4,4,4,4,"BG/MP # 112",".ANG., .CANCER., .CCKR., .CCP., .CCY., .CD., .CML., .CSP., .DDR., .EGFR., .FGFR., .IMUF., .INFG., .INFM., .INS., .INT., .MAPK., .OP., .OPA., .OT., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TRASR.","CCKR signaling map; FGF signaling pathway; Interferon-gamma signaling pathway; Angiogenesis","TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11","abortive mitotic cell cycle; atrioventricular canal development; axonogenesis; Bergmann glial cell differentiation; brain development; cellular response to epidermal growth factor stimulus; cellular response to organic substance; cerebellar cortex formation; cytokine-mediated signaling pathway; dephosphorylation; DNA damage checkpoint signaling; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB signaling pathway; face morphogenesis; fibroblast growth factor receptor signaling pathway; genitalia development; glucose homeostasis; heart development; homeostasis of number of cells within a tissue; hormone metabolic process; hormone-mediated signaling pathway; inner ear development; integrin-mediated signaling pathway; intestinal epithelial cell migration; lipid metabolic process; megakaryocyte development; microvillus organization; multicellular organism growth; multicellular organismal reproductive process; negative regulation of cell adhesion mediated by integrin; negative regulation of chondrocyte differentiation; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of hormone secretion; negative regulation of insulin secretion; neurotrophin TRK receptor signaling pathway; organ growth; peptidyl-tyrosine dephosphorylation; platelet formation; platelet-derived growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of glucose import; positive regulation of hormone secretion; positive regulation of insulin receptor signaling pathway; positive regulation of interferon-beta production; positive regulation of interleukin-6 production; positive regulation of mitotic cell cycle; positive regulation of ossification; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of signal transduction; positive regulation of tumor necrosis factor production; protein dephosphorylation; regulation of cell adhesion mediated by integrin; regulation of MAPK cascade; regulation of protein export from nucleus; regulation of protein-containing complex assembly; regulation of type I interferon-mediated signaling pathway; signal transduction; T cell costimulation; triglyceride metabolic process","cadherin binding; cell adhesion molecule binding; hydrolase activity; insulin receptor binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phosphatase activity; phosphoprotein phosphatase activity; phosphotyrosine residue binding; protein binding; protein kinase binding; protein tyrosine kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; signaling receptor complex adaptor activity","cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex","Tyrosine phosphatase","protein tyrosine phosphatase non-receptor type 11","http://www.ncbi.nlm.nih.gov/gene/?term=5781","5781","19247",null,"477488",null,"712044","Q06124","P35235","A0A8I6GI01","A0A4D6PF96","A0A287AQB6","H9FXT1","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0032991","GO:0045296; GO:0050839; GO:0016787; GO:0005158; GO:0004726; GO:0051428; GO:0016791; GO:0004721; GO:0001784; GO:0005515; GO:0019901; GO:1990782; GO:0004725; GO:0030971; GO:0030159","GO:0033277; GO:0036302; GO:0007409; GO:0060020; GO:0007420; GO:0071364; GO:0071310; GO:0021697; GO:0019221; GO:0016311; GO:0000077; GO:0048013; GO:0007173; GO:0038127; GO:0060325; GO:0008543; GO:0048806; GO:0042593; GO:0007507; GO:0048873; GO:0042445; GO:0009755; GO:0048839; GO:0007229; GO:0061582; GO:0006629; GO:0035855; GO:0032528; GO:0035264; GO:0048609; GO:0033629; GO:0032331; GO:0051463; GO:0060125; GO:0046888; GO:0046676; GO:0048011; GO:0035265; GO:0035335; GO:0030220; GO:0048008; GO:0070374; GO:0046326; GO:0046887; GO:0046628; GO:0032728; GO:0032755; GO:0045931; GO:0045778; GO:0050731; GO:0009967; GO:0032760; GO:0006470; GO:0033628; GO:0043408; GO:0046825; GO:0043254; GO:0060338; GO:0007165; GO:0031295; GO:0006641","PTHR46559:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9644|UniProtKB=Q06124","P06959; P00021; P00035; P00005"]
["SHP-2 - phospho","Tyr582","PTPN11","72","rb",null,4,4,"n/a","n/a","n/a","n/a","# 0214",".ANG., .CANCER., .CCKR., .CCP., .CCY., .CD., .CML., .CSP., .DDR., .EGFR., .FGFR., .IMUF., .INFG., .INFM., .INS., .INT., .MAPK., .OP., .OPA., .OT., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TRASR.","CCKR signaling map; FGF signaling pathway; Interferon-gamma signaling pathway; Angiogenesis","TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11","abortive mitotic cell cycle; atrioventricular canal development; axonogenesis; Bergmann glial cell differentiation; brain development; cellular response to epidermal growth factor stimulus; cellular response to organic substance; cerebellar cortex formation; cytokine-mediated signaling pathway; dephosphorylation; DNA damage checkpoint signaling; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB signaling pathway; face morphogenesis; fibroblast growth factor receptor signaling pathway; genitalia development; glucose homeostasis; heart development; homeostasis of number of cells within a tissue; hormone metabolic process; hormone-mediated signaling pathway; inner ear development; integrin-mediated signaling pathway; intestinal epithelial cell migration; lipid metabolic process; megakaryocyte development; microvillus organization; multicellular organism growth; multicellular organismal reproductive process; negative regulation of cell adhesion mediated by integrin; negative regulation of chondrocyte differentiation; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of hormone secretion; negative regulation of insulin secretion; neurotrophin TRK receptor signaling pathway; organ growth; peptidyl-tyrosine dephosphorylation; platelet formation; platelet-derived growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of glucose import; positive regulation of hormone secretion; positive regulation of insulin receptor signaling pathway; positive regulation of interferon-beta production; positive regulation of interleukin-6 production; positive regulation of mitotic cell cycle; positive regulation of ossification; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of signal transduction; positive regulation of tumor necrosis factor production; protein dephosphorylation; regulation of cell adhesion mediated by integrin; regulation of MAPK cascade; regulation of protein export from nucleus; regulation of protein-containing complex assembly; regulation of type I interferon-mediated signaling pathway; signal transduction; T cell costimulation; triglyceride metabolic process","cadherin binding; cell adhesion molecule binding; hydrolase activity; insulin receptor binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phosphatase activity; phosphoprotein phosphatase activity; phosphotyrosine residue binding; protein binding; protein kinase binding; protein tyrosine kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; signaling receptor complex adaptor activity","cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex","Tyrosine phosphatase","protein tyrosine phosphatase non-receptor type 11","http://www.ncbi.nlm.nih.gov/gene/?term=5781","5781","19247",null,"477488",null,"712044","Q06124","P35235","A0A8I6GI01","A0A4D6PF96","A0A287AQB6","H9FXT1","GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0032991","GO:0045296; GO:0050839; GO:0016787; GO:0005158; GO:0004726; GO:0051428; GO:0016791; GO:0004721; GO:0001784; GO:0005515; GO:0019901; GO:1990782; GO:0004725; GO:0030971; GO:0030159","GO:0033277; GO:0036302; GO:0007409; GO:0060020; GO:0007420; GO:0071364; GO:0071310; GO:0021697; GO:0019221; GO:0016311; GO:0000077; GO:0048013; GO:0007173; GO:0038127; GO:0060325; GO:0008543; GO:0048806; GO:0042593; GO:0007507; GO:0048873; GO:0042445; GO:0009755; GO:0048839; GO:0007229; GO:0061582; GO:0006629; GO:0035855; GO:0032528; GO:0035264; GO:0048609; GO:0033629; GO:0032331; GO:0051463; GO:0060125; GO:0046888; GO:0046676; GO:0048011; GO:0035265; GO:0035335; GO:0030220; GO:0048008; GO:0070374; GO:0046326; GO:0046887; GO:0046628; GO:0032728; GO:0032755; GO:0045931; GO:0045778; GO:0050731; GO:0009967; GO:0032760; GO:0006470; GO:0033628; GO:0043408; GO:0046825; GO:0043254; GO:0060338; GO:0007165; GO:0031295; GO:0006641","PTHR46559:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9644|UniProtKB=Q06124","P06959; P00021; P00035; P00005"]
["SIK3 (KIAA0999)",null,"SIK3","140","rb",null,7,7,"n/a","n/a","n/a","n/a","# 1336",".CSP., .MTOR., .OPA., .RTK., .ST.",null,"SERINE/THREONINE-PROTEIN KINASE SIK3","intracellular signal transduction; microtubule cytoskeleton organization; phosphorylation; positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; protein phosphorylation","ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; transferase activity","cytoplasm; nucleoplasm",null,"SIK family kinase 3","http://www.ncbi.nlm.nih.gov/gene/?term=23387","23387","70661","684112",null,null,null,"Q9Y2K2","Q6P4S6","A0A8I6A0T3","A0A8I3MPL8","A0A286ZTQ6","A0A1D5Q6B4","GO:0005737; GO:0005654","GO:0005524; GO:0016301; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0050321; GO:0016740","GO:0035556; GO:0000226; GO:0016310; GO:1904263; GO:1904515; GO:0006468","PTHR24346:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=29165|UniProtKB=Q9Y2K2"]
["SLP-76",null,"LCP2","76","rb",null,1,2,"n/a","n/a","n/a","n/a","# 1903",".CSP., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .PLAT., .ST., .TCR.","T cell activation","LYMPHOCYTE CYTOSOLIC PROTEIN 2","immune response; intracellular signal transduction; mast cell activation; positive regulation of protein kinase activity; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","protein binding","cell-cell junction; cytoplasm; cytosol; plasma membrane raft; TCR signalosome",null,"lymphocyte cytosolic protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=3937","3937","16822",null,"489126",null,null,"Q13094","Q60787","A0A8I6AC21","A0A8I3MGV8","A0A5G2QHY0","A0A1D5RBZ2","GO:0005911; GO:0005737; GO:0005829; GO:0044853; GO:0036398","GO:0005515","GO:0006955; GO:0035556; GO:0045576; GO:0045860; GO:0050852; GO:0007169","PTHR14098:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6529|UniProtKB=Q13094","P00053"]
["SLP-76 - phospho","Ser376","LCP2","76","rb",null,1,4,"n/a","n/a","n/a","n/a","# 1938",".CSP., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .PLAT., .ST., .TCR.","T cell activation","LYMPHOCYTE CYTOSOLIC PROTEIN 2","immune response; intracellular signal transduction; mast cell activation; positive regulation of protein kinase activity; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","protein binding","cell-cell junction; cytoplasm; cytosol; plasma membrane raft; TCR signalosome",null,"lymphocyte cytosolic protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=3937","3937","16822",null,"489126",null,null,"Q13094","Q60787","A0A8I6AC21","A0A8I3MGV8","A0A5G2QHY0","A0A1D5RBZ2","GO:0005911; GO:0005737; GO:0005829; GO:0044853; GO:0036398","GO:0005515","GO:0006955; GO:0035556; GO:0045576; GO:0045860; GO:0050852; GO:0007169","PTHR14098:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6529|UniProtKB=Q13094","P00053"]
["SLP-76 - phospho","Tyr113","LCP2","76","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1982",".CSP., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .PLAT., .ST., .TCR.","T cell activation","LYMPHOCYTE CYTOSOLIC PROTEIN 2","immune response; intracellular signal transduction; mast cell activation; positive regulation of protein kinase activity; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","protein binding","cell-cell junction; cytoplasm; cytosol; plasma membrane raft; TCR signalosome",null,"lymphocyte cytosolic protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=3937","3937","16822",null,"489126",null,null,"Q13094","Q60787","A0A8I6AC21","A0A8I3MGV8","A0A5G2QHY0","A0A1D5RBZ2","GO:0005911; GO:0005737; GO:0005829; GO:0044853; GO:0036398","GO:0005515","GO:0006955; GO:0035556; GO:0045576; GO:0045860; GO:0050852; GO:0007169","PTHR14098:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6529|UniProtKB=Q13094","P00053"]
["SLP-76 - phospho","Tyr128","LCP2","76","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1983",".CSP., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .PLAT., .ST., .TCR.","T cell activation","LYMPHOCYTE CYTOSOLIC PROTEIN 2","immune response; intracellular signal transduction; mast cell activation; positive regulation of protein kinase activity; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","protein binding","cell-cell junction; cytoplasm; cytosol; plasma membrane raft; TCR signalosome",null,"lymphocyte cytosolic protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=3937","3937","16822",null,"489126",null,null,"Q13094","Q60787","A0A8I6AC21","A0A8I3MGV8","A0A5G2QHY0","A0A1D5RBZ2","GO:0005911; GO:0005737; GO:0005829; GO:0044853; GO:0036398","GO:0005515","GO:0006955; GO:0035556; GO:0045576; GO:0045860; GO:0050852; GO:0007169","PTHR14098:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6529|UniProtKB=Q13094","P00053"]
["SLP-76 - phospho","Tyr145","LCP2","76","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1939",".CSP., .IMU., .IMUF., .IMUR., .OP., .OPA., .OT., .PLAT., .ST., .TCR.","T cell activation","LYMPHOCYTE CYTOSOLIC PROTEIN 2","immune response; intracellular signal transduction; mast cell activation; positive regulation of protein kinase activity; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway","protein binding","cell-cell junction; cytoplasm; cytosol; plasma membrane raft; TCR signalosome",null,"lymphocyte cytosolic protein 2","http://www.ncbi.nlm.nih.gov/gene/?term=3937","3937","16822",null,"489126",null,null,"Q13094","Q60787","A0A8I6AC21","A0A8I3MGV8","A0A5G2QHY0","A0A1D5RBZ2","GO:0005911; GO:0005737; GO:0005829; GO:0044853; GO:0036398","GO:0005515","GO:0006955; GO:0035556; GO:0045576; GO:0045860; GO:0050852; GO:0007169","PTHR14098:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6529|UniProtKB=Q13094","P00053"]
["Slug",null,"SNAI2","30","rb",null,1.1000000000000001,1,8,8,8,8,"# 1355",".APO., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .EGFR., .HIPPO., .MIG., .NOTCH., .OP., .OPA., .OT., .P53S., .RTK., .ST., .TRASR., .WNT.",null,"ZINC FINGER PROTEIN SNAI2","aortic valve morphogenesis; cartilage morphogenesis; cell migration involved in endocardial cushion formation; cellular response to epidermal growth factor stimulus; cellular response to ionizing radiation; desmosome disassembly; endothelial cell migration; epithelial cell migration; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; epithelium development; hematopoietic stem cell proliferation; myeloid cell apoptotic process; negative regulation of anoikis; negative regulation of canonical Wnt signaling pathway; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cell adhesion mediated by integrin; negative regulation of chondrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of hematopoietic stem cell proliferation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of keratinocyte proliferation; negative regulation of myeloid cell apoptotic process; negative regulation of transcription by RNA polymerase II; negative regulation of vitamin D biosynthetic process; negative regulation of vitamin D receptor signaling pathway; neural crest cell development; Notch signaling involved in heart development; Notch signaling pathway; osteoblast differentiation; pigmentation; positive regulation of cell migration; positive regulation of fat cell differentiation; positive regulation of histone acetylation; regulation of bicellular tight junction assembly; regulation of branching involved in salivary gland morphogenesis; regulation of chemokine production; regulation of DNA-templated transcription; regulation of osteoblast differentiation; response to radiation; roof of mouth development; sensory perception of sound; substrate-dependent cell migration; white fat cell differentiation","chromatin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding","chromatin; cytoplasm; nucleoplasm; nucleus","Development","snail family transcriptional repressor 2","http://www.ncbi.nlm.nih.gov/gene/?term=6591","6591","20583","25554",null,null,"708962","O43623","P97469","O08954","A0A8I3Q0X5",null,"F7FPY3","GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0000981; GO:0001227; GO:0070888; GO:0046872; GO:0005515; GO:0000978; GO:0000977; GO:0043565; GO:1990837","GO:0003180; GO:0060536; GO:0003273; GO:0071364; GO:0071479; GO:0035921; GO:0043542; GO:0010631; GO:0001837; GO:0003198; GO:0060429; GO:0071425; GO:0033028; GO:2000811; GO:0090090; GO:0006933; GO:0033629; GO:0032331; GO:0043518; GO:2001240; GO:1902034; GO:1902230; GO:0010839; GO:0033033; GO:0000122; GO:0010957; GO:0070563; GO:0014032; GO:0061314; GO:0007219; GO:0001649; GO:0043473; GO:0030335; GO:0045600; GO:0035066; GO:2000810; GO:0060693; GO:0032642; GO:0006355; GO:0045667; GO:0009314; GO:0060021; GO:0007605; GO:0006929; GO:0050872","PTHR24388:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11094|UniProtKB=O43623"]
["Smad1",null,"SMAD1","60","rb",null,2,1,4,4,1,1.1000000000000001,"# 2093",".ANG., .BMP., .CANCER., .CCP., .CP., .CSP., .DEV., .HIPPO., .IMFR., .IMUR., .MAPK., .OP., .OPA., .OT., .RTK., .ST., .TGFB., .TRASR., .WNT.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway; Wnt signaling pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1","anatomical structure morphogenesis; BMP signaling pathway; bone development; cardiac conduction system development; cardiac muscle cell proliferation; cartilage development; cell differentiation; cell population proliferation; cellular response to BMP stimulus; cellular response to organic cyclic compound; DNA-templated transcription; embryonic pattern specification; gamete generation; hindbrain development; homeostatic process; inflammatory response; MAPK cascade; mesodermal cell fate commitment; midbrain development; negative regulation of cell population proliferation; negative regulation of muscle cell differentiation; osteoblast differentiation; osteoblast fate commitment; positive regulation of cartilage development; positive regulation of gene expression; positive regulation of miRNA transcription; positive regulation of osteoblast differentiation; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; primary miRNA processing; protein phosphorylation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; signal transduction; SMAD protein complex assembly; SMAD protein signal transduction; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; ureteric bud development","co-SMAD binding; DEAD/H-box RNA helicase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; I-SMAD binding; metal ion binding; primary miRNA binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding","chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; homomeric SMAD protein complex; membrane; nuclear inner membrane; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription regulator complex","TGF-beta / Smad signaling","SMAD family member 1","http://www.ncbi.nlm.nih.gov/gene/?term=4086","4086","17125","25671",null,null,"574340","Q15797","P70340","A0A0G2JSQ6","A0A8I3NLA4","A0A286ZLR6","F7GZM0","GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0071142; GO:0016020; GO:0005637; GO:0005654; GO:0005634; GO:0032991; GO:0071141; GO:0005667","GO:0070410; GO:0017151; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0042802; GO:0070411; GO:0046872; GO:0070878; GO:0005515; GO:0019901; GO:0000978; GO:0043565","GO:0009653; GO:0030509; GO:0060348; GO:0003161; GO:0060038; GO:0051216; GO:0030154; GO:0008283; GO:0071773; GO:0071407; GO:0006351; GO:0009880; GO:0007276; GO:0030902; GO:0042592; GO:0006954; GO:0000165; GO:0001710; GO:0030901; GO:0008285; GO:0051148; GO:0001649; GO:0002051; GO:0061036; GO:0010628; GO:1902895; GO:0045669; GO:1903672; GO:0045944; GO:1901522; GO:0031053; GO:0006468; GO:0006355; GO:0006357; GO:0007165; GO:0007183; GO:0060395; GO:0006366; GO:0007179; GO:0001657","PTHR13703:SF23","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6767|UniProtKB=Q15797","P00052; P06664; P00057"]
["Smad2",null,"SMAD2","60","rb",null,2,2,1,8,2,2,"# 2056",".BMP., .CANCER., .CANPTHW., .CCP., .CCY., .CP., .CRC., .CSP., .DEV., .HIPPO., .OP., .OPA., .OT., .PAC., .ST., .TCD., .TGFB., .TMAT., .TRASR.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2","activin receptor signaling pathway; adrenal gland development; anatomical structure morphogenesis; anterior/posterior pattern specification; aortic valve morphogenesis; cell differentiation; cell fate commitment; common-partner SMAD protein phosphorylation; developmental growth; DNA-templated transcription; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endocardial cushion morphogenesis; endoderm development; endoderm formation; gastrulation; heart development; in utero embryonic development; insulin secretion; intracellular signal transduction; lung development; mesoderm formation; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of gene expression; nodal signaling pathway; organ growth; pancreas development; paraxial mesoderm morphogenesis; pattern specification process; pericardium development; positive regulation of BMP signaling pathway; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; positive regulation of transcription by RNA polymerase II; post-embryonic development; primary miRNA processing; protein phosphorylation; pulmonary valve morphogenesis; regulation of binding; regulation of DNA-templated transcription; regulation of transforming growth factor beta receptor signaling pathway; response to cholesterol; response to glucose; secondary palate development; signal transduction involved in regulation of gene expression; SMAD protein complex assembly; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing; zygotic specification of dorsal/ventral axis","chromatin binding; cis-regulatory region sequence-specific DNA binding; co-SMAD binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; double-stranded DNA binding; identical protein binding; I-SMAD binding; metal ion binding; phosphatase binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; SMAD binding; tau protein binding; transforming growth factor beta receptor binding; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding","activin responsive factor complex; chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; homomeric SMAD protein complex; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription regulator complex","TGF-beta / Smad signaling","SMAD family member 2","http://www.ncbi.nlm.nih.gov/gene/?term=4087","4087","17126","29357",null,"100155304","697581","Q15796","Q62432","O70436","A0A8I3MF91","A0A287AE86","F7CIW0","GO:0032444; GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0071142; GO:0005654; GO:0005634; GO:0032991; GO:0071141; GO:0005667","GO:0003682; GO:0000987; GO:0070410; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0003690; GO:0042802; GO:0070411; GO:0046872; GO:0019902; GO:0005515; GO:0000978; GO:0061629; GO:0070412; GO:0046332; GO:0048156; GO:0005160; GO:0034713; GO:0031625","GO:0032924; GO:0030325; GO:0009653; GO:0009952; GO:0003180; GO:0030154; GO:0045165; GO:0007182; GO:0048589; GO:0006351; GO:0048701; GO:0048617; GO:0009880; GO:0003203; GO:0007492; GO:0001706; GO:0007369; GO:0007507; GO:0001701; GO:0030073; GO:0035556; GO:0030324; GO:0001707; GO:0008285; GO:0045892; GO:0010629; GO:0038092; GO:0035265; GO:0031016; GO:0048340; GO:0007389; GO:0060039; GO:0030513; GO:0045893; GO:0010718; GO:0010628; GO:1900224; GO:0045944; GO:0009791; GO:0031053; GO:0006468; GO:0003184; GO:0051098; GO:0006355; GO:0017015; GO:0070723; GO:0009749; GO:0062009; GO:0023019; GO:0007183; GO:0060395; GO:0007179; GO:0001657; GO:0042060; GO:0007352","PTHR13703:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6768|UniProtKB=Q15796","P00052; P06664"]
["Smad2 - phospho","Ser245/Ser250/Ser255","SMAD2","60","rb",null,6.1,4,5,5,5,5,"TK # 101",".BMP., .CANCER., .CANPTHW., .CCP., .CCY., .CP., .CRC., .CSP., .DEV., .HIPPO., .OP., .OPA., .OT., .PAC., .ST., .TCD., .TGFB., .TMAT., .TRASR.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2","activin receptor signaling pathway; adrenal gland development; anatomical structure morphogenesis; anterior/posterior pattern specification; aortic valve morphogenesis; cell differentiation; cell fate commitment; common-partner SMAD protein phosphorylation; developmental growth; DNA-templated transcription; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endocardial cushion morphogenesis; endoderm development; endoderm formation; gastrulation; heart development; in utero embryonic development; insulin secretion; intracellular signal transduction; lung development; mesoderm formation; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of gene expression; nodal signaling pathway; organ growth; pancreas development; paraxial mesoderm morphogenesis; pattern specification process; pericardium development; positive regulation of BMP signaling pathway; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; positive regulation of transcription by RNA polymerase II; post-embryonic development; primary miRNA processing; protein phosphorylation; pulmonary valve morphogenesis; regulation of binding; regulation of DNA-templated transcription; regulation of transforming growth factor beta receptor signaling pathway; response to cholesterol; response to glucose; secondary palate development; signal transduction involved in regulation of gene expression; SMAD protein complex assembly; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing; zygotic specification of dorsal/ventral axis","chromatin binding; cis-regulatory region sequence-specific DNA binding; co-SMAD binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; double-stranded DNA binding; identical protein binding; I-SMAD binding; metal ion binding; phosphatase binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; SMAD binding; tau protein binding; transforming growth factor beta receptor binding; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding","activin responsive factor complex; chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; homomeric SMAD protein complex; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription regulator complex","TGF-beta / Smad signaling","SMAD family member 2","http://www.ncbi.nlm.nih.gov/gene/?term=4087","4087","17126","29357",null,"100155304","697581","Q15796","Q62432","O70436","A0A8I3MF91","A0A287AE86","F7CIW0","GO:0032444; GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0071142; GO:0005654; GO:0005634; GO:0032991; GO:0071141; GO:0005667","GO:0003682; GO:0000987; GO:0070410; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0003690; GO:0042802; GO:0070411; GO:0046872; GO:0019902; GO:0005515; GO:0000978; GO:0061629; GO:0070412; GO:0046332; GO:0048156; GO:0005160; GO:0034713; GO:0031625","GO:0032924; GO:0030325; GO:0009653; GO:0009952; GO:0003180; GO:0030154; GO:0045165; GO:0007182; GO:0048589; GO:0006351; GO:0048701; GO:0048617; GO:0009880; GO:0003203; GO:0007492; GO:0001706; GO:0007369; GO:0007507; GO:0001701; GO:0030073; GO:0035556; GO:0030324; GO:0001707; GO:0008285; GO:0045892; GO:0010629; GO:0038092; GO:0035265; GO:0031016; GO:0048340; GO:0007389; GO:0060039; GO:0030513; GO:0045893; GO:0010718; GO:0010628; GO:1900224; GO:0045944; GO:0009791; GO:0031053; GO:0006468; GO:0003184; GO:0051098; GO:0006355; GO:0017015; GO:0070723; GO:0009749; GO:0062009; GO:0023019; GO:0007183; GO:0060395; GO:0007179; GO:0001657; GO:0042060; GO:0007352","PTHR13703:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6768|UniProtKB=Q15796","P00052; P06664"]
["Smad2 - phospho","Ser465/Ser467","SMAD2","60","rb",null,6.1,4,8,8,8,8,"# 0947",".BMP., .CANCER., .CANPTHW., .CCP., .CCY., .CP., .CRC., .CSP., .DEV., .HIPPO., .OP., .OPA., .OT., .PAC., .ST., .TCD., .TGFB., .TMAT., .TRASR.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2","activin receptor signaling pathway; adrenal gland development; anatomical structure morphogenesis; anterior/posterior pattern specification; aortic valve morphogenesis; cell differentiation; cell fate commitment; common-partner SMAD protein phosphorylation; developmental growth; DNA-templated transcription; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endocardial cushion morphogenesis; endoderm development; endoderm formation; gastrulation; heart development; in utero embryonic development; insulin secretion; intracellular signal transduction; lung development; mesoderm formation; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of gene expression; nodal signaling pathway; organ growth; pancreas development; paraxial mesoderm morphogenesis; pattern specification process; pericardium development; positive regulation of BMP signaling pathway; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; positive regulation of transcription by RNA polymerase II; post-embryonic development; primary miRNA processing; protein phosphorylation; pulmonary valve morphogenesis; regulation of binding; regulation of DNA-templated transcription; regulation of transforming growth factor beta receptor signaling pathway; response to cholesterol; response to glucose; secondary palate development; signal transduction involved in regulation of gene expression; SMAD protein complex assembly; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing; zygotic specification of dorsal/ventral axis","chromatin binding; cis-regulatory region sequence-specific DNA binding; co-SMAD binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; double-stranded DNA binding; identical protein binding; I-SMAD binding; metal ion binding; phosphatase binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; SMAD binding; tau protein binding; transforming growth factor beta receptor binding; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding","activin responsive factor complex; chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; homomeric SMAD protein complex; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription regulator complex","TGF-beta / Smad signaling","SMAD family member 2","http://www.ncbi.nlm.nih.gov/gene/?term=4087","4087","17126","29357",null,"100155304","697581","Q15796","Q62432","O70436","A0A8I3MF91","A0A287AE86","F7CIW0","GO:0032444; GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0071142; GO:0005654; GO:0005634; GO:0032991; GO:0071141; GO:0005667","GO:0003682; GO:0000987; GO:0070410; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0003690; GO:0042802; GO:0070411; GO:0046872; GO:0019902; GO:0005515; GO:0000978; GO:0061629; GO:0070412; GO:0046332; GO:0048156; GO:0005160; GO:0034713; GO:0031625","GO:0032924; GO:0030325; GO:0009653; GO:0009952; GO:0003180; GO:0030154; GO:0045165; GO:0007182; GO:0048589; GO:0006351; GO:0048701; GO:0048617; GO:0009880; GO:0003203; GO:0007492; GO:0001706; GO:0007369; GO:0007507; GO:0001701; GO:0030073; GO:0035556; GO:0030324; GO:0001707; GO:0008285; GO:0045892; GO:0010629; GO:0038092; GO:0035265; GO:0031016; GO:0048340; GO:0007389; GO:0060039; GO:0030513; GO:0045893; GO:0010718; GO:0010628; GO:1900224; GO:0045944; GO:0009791; GO:0031053; GO:0006468; GO:0003184; GO:0051098; GO:0006355; GO:0017015; GO:0070723; GO:0009749; GO:0062009; GO:0023019; GO:0007183; GO:0060395; GO:0007179; GO:0001657; GO:0042060; GO:0007352","PTHR13703:SF42","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6768|UniProtKB=Q15796","P00052; P06664"]
["Smad2/3",null,"SMAD2, SMAD3","60, 52","rb",null,2,1,1,1,1,1,"TK # 100",".APO., .BMP., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .FOXO., .HEPB., .HIF., .HIPPO., .IMFR., .IMU., .IMUF., .IMUR., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .PAC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TRASR., .VIR., .WNT.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3","activin receptor signaling pathway; adrenal gland development; anatomical structure morphogenesis; anterior/posterior pattern specification; aortic valve morphogenesis; cell differentiation; cell fate commitment; common-partner SMAD protein phosphorylation; developmental growth; DNA-templated transcription; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endocardial cushion morphogenesis; endoderm development; endoderm formation; gastrulation; heart development; in utero embryonic development; insulin secretion; intracellular signal transduction; lung development; mesoderm formation; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of gene expression; nodal signaling pathway; organ growth; pancreas development; paraxial mesoderm morphogenesis; pattern specification process; pericardium development; positive regulation of BMP signaling pathway; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of gene expression; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; positive regulation of transcription by RNA polymerase II; post-embryonic development; primary miRNA processing; protein phosphorylation; pulmonary valve morphogenesis; regulation of binding; regulation of DNA-templated transcription; regulation of transforming growth factor beta receptor signaling pathway; response to cholesterol; response to glucose; secondary palate development; signal transduction involved in regulation of gene expression; SMAD protein complex assembly; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing; zygotic specification of dorsal/ventral axis; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cell-cell junction organization; cellular response to transforming growth factor beta stimulus; cellular response to virus; extrinsic apoptotic signaling pathway; heart looping; immune response; immune system development; JNK cascade; lens fiber cell differentiation; liver development; MAPK cascade; negative regulation of apoptotic process; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of cell growth; negative regulation of cytosolic calcium ion concentration; negative regulation of fat cell differentiation; negative regulation of inflammatory response; negative regulation of lung blood pressure; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of protein catabolic process; negative regulation of transcription by RNA polymerase II; negative regulation of wound healing; osteoblast development; osteoblast differentiation; positive regulation of alkaline phosphatase activity; positive regulation of bone mineralization; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of chondrocyte differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of extracellular matrix assembly; positive regulation of focal adhesion assembly; positive regulation of interleukin-1 beta production; positive regulation of miRNA transcription; positive regulation of nitric oxide biosynthetic process; positive regulation of positive chemotaxis; positive regulation of protein import into nucleus; positive regulation of stress fiber assembly; positive regulation of transforming growth factor beta3 production; protein stabilization; regulation of epithelial cell proliferation; regulation of immune response; regulation of miRNA transcription; regulation of striated muscle tissue development; regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta2 production; response to hypoxia; skeletal system development; somitogenesis; T cell activation; thyroid gland development; transdifferentiation","chromatin binding; cis-regulatory region sequence-specific DNA binding; co-SMAD binding; disordered domain specific binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; double-stranded DNA binding; identical protein binding; I-SMAD binding; metal ion binding; phosphatase binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; SMAD binding; tau protein binding; transforming growth factor beta receptor binding; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding; beta-catenin binding; bHLH transcription factor binding; chromatin DNA binding; collagen binding; DEAD/H-box RNA helicase binding; DNA-binding transcription repressor activity; enzyme binding; nuclear glucocorticoid receptor binding; nuclear mineralocorticoid receptor binding; nuclear receptor binding; promoter-specific chromatin binding; protein homodimerization activity; protein kinase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sterol response element binding; transcription cis-regulatory region binding; transcription coactivator binding; ubiquitin binding; zinc ion binding","activin responsive factor complex; chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; homomeric SMAD protein complex; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription regulator complex; nuclear inner membrane; plasma membrane; receptor complex","TGF-beta / Smad signaling","SMAD family member 2; SMAD family member 3","http://www.ncbi.nlm.nih.gov/gene/?term=4087, http://www.ncbi.nlm.nih.gov/gene/?term=4088","4087, 4088","17126, 17127","29357, 25631",null,"100155304, 397260","697581, 711355","Q15796, P84022","Q62432, Q8BUN5","O70436, P84025","A0A8I3MF91, A0A8I3P2U7","A0A287AE86, P84024","F7CIW0, A0A1D5Q1C9","GO:0032444; GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0071142; GO:0005654; GO:0005634; GO:0032991; GO:0071141; GO:0005667; GO:0005637; GO:0005886; GO:0043235","GO:0003682; GO:0000987; GO:0070410; GO:0097718; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0003690; GO:0042802; GO:0070411; GO:0046872; GO:0019902; GO:0005515; GO:0000978; GO:0061629; GO:0070412; GO:0046332; GO:0048156; GO:0005160; GO:0034713; GO:0031625; GO:0008013; GO:0043425; GO:0031490; GO:0005518; GO:0017151; GO:0001217; GO:0019899; GO:0035259; GO:0031962; GO:0016922; GO:1990841; GO:0042803; GO:0019901; GO:0000977; GO:0043565; GO:0032810; GO:0000976; GO:0001223; GO:0043130; GO:0008270","GO:0032924; GO:0030325; GO:0009653; GO:0009952; GO:0003180; GO:0030154; GO:0045165; GO:0007182; GO:0048589; GO:0006351; GO:0048701; GO:0048617; GO:0009880; GO:0003203; GO:0007492; GO:0001706; GO:0007369; GO:0007507; GO:0001701; GO:0030073; GO:0035556; GO:0030324; GO:0001707; GO:0008285; GO:0045892; GO:0010629; GO:0038092; GO:0035265; GO:0031016; GO:0048340; GO:0007389; GO:0060039; GO:0030513; GO:0045893; GO:0010718; GO:0010628; GO:1900224; GO:0045944; GO:0009791; GO:0031053; GO:0006468; GO:0003184; GO:0051098; GO:0006355; GO:0017015; GO:0070723; GO:0009749; GO:0062009; GO:0023019; GO:0007183; GO:0060395; GO:0007179; GO:0001657; GO:0042060; GO:0007352; GO:0006919; GO:0097296; GO:0045216; GO:0071560; GO:0098586; GO:0097191; GO:0001947; GO:0006955; GO:0002520; GO:0007254; GO:0070306; GO:0001889; GO:0000165; GO:0043066; GO:1903243; GO:0030308; GO:0051481; GO:0045599; GO:0050728; GO:0061767; GO:0045668; GO:0033689; GO:0042177; GO:0000122; GO:0061045; GO:0002076; GO:0001649; GO:0010694; GO:0030501; GO:0090263; GO:0030335; GO:0032332; GO:0051091; GO:1901203; GO:0051894; GO:0032731; GO:1902895; GO:0045429; GO:0050927; GO:0042307; GO:0051496; GO:0032916; GO:0050821; GO:0050678; GO:0050776; GO:1902893; GO:0016202; GO:0006357; GO:0032909; GO:0001666; GO:0001501; GO:0001756; GO:0042110; GO:0030878; GO:0060290","PTHR13703:SF42; PTHR13703:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6768|UniProtKB=Q15796; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6769|UniProtKB=P84022","P00052; P06664"]
["Smad3",null,"SMAD3","52","rb",null,2,2,5,1,1,8,"# 2053",".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .FOXO., .HEPB., .HIF., .HIPPO., .IMFR., .IMU., .IMUF., .IMUR., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .PAC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TRASR., .VIR., .WNT.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3","activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; activin receptor signaling pathway; adrenal gland development; anatomical structure morphogenesis; cell differentiation; cell-cell junction organization; cellular response to transforming growth factor beta stimulus; cellular response to virus; developmental growth; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endoderm development; extrinsic apoptotic signaling pathway; gastrulation; heart looping; immune response; immune system development; in utero embryonic development; JNK cascade; lens fiber cell differentiation; liver development; MAPK cascade; mesoderm formation; negative regulation of apoptotic process; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cytosolic calcium ion concentration; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of lung blood pressure; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of protein catabolic process; negative regulation of transcription by RNA polymerase II; negative regulation of wound healing; nodal signaling pathway; osteoblast development; osteoblast differentiation; paraxial mesoderm morphogenesis; pericardium development; positive regulation of alkaline phosphatase activity; positive regulation of bone mineralization; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of chondrocyte differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of extracellular matrix assembly; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of miRNA transcription; positive regulation of nitric oxide biosynthetic process; positive regulation of positive chemotaxis; positive regulation of protein import into nucleus; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta3 production; primary miRNA processing; protein stabilization; regulation of binding; regulation of DNA-templated transcription; regulation of epithelial cell proliferation; regulation of immune response; regulation of miRNA transcription; regulation of striated muscle tissue development; regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor beta2 production; response to hypoxia; signal transduction involved in regulation of gene expression; skeletal system development; SMAD protein complex assembly; SMAD protein signal transduction; somitogenesis; T cell activation; thyroid gland development; transdifferentiation; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing","beta-catenin binding; bHLH transcription factor binding; chromatin binding; chromatin DNA binding; cis-regulatory region sequence-specific DNA binding; collagen binding; co-SMAD binding; DEAD/H-box RNA helicase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity; double-stranded DNA binding; enzyme binding; identical protein binding; I-SMAD binding; metal ion binding; nuclear glucocorticoid receptor binding; nuclear mineralocorticoid receptor binding; nuclear receptor binding; phosphatase binding; promoter-specific chromatin binding; protein binding; protein homodimerization activity; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; sequence-specific DNA binding; SMAD binding; sterol response element binding; transcription cis-regulatory region binding; transcription coactivator binding; transforming growth factor beta receptor binding; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding","chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; nuclear inner membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; receptor complex; SMAD protein complex; transcription regulator complex","TGF-beta / Smad signaling","SMAD family member 3","http://www.ncbi.nlm.nih.gov/gene/?term=4088","4088","17127","25631",null,"397260","711355","P84022","Q8BUN5","P84025","A0A8I3P2U7","P84024","A0A1D5Q1C9","GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0005637; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0043235; GO:0071141; GO:0005667","GO:0008013; GO:0043425; GO:0003682; GO:0031490; GO:0000987; GO:0005518; GO:0070410; GO:0017151; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001217; GO:0003690; GO:0019899; GO:0042802; GO:0070411; GO:0046872; GO:0035259; GO:0031962; GO:0016922; GO:0019902; GO:1990841; GO:0005515; GO:0042803; GO:0019901; GO:0000978; GO:0000977; GO:0061629; GO:0070412; GO:0043565; GO:0046332; GO:0032810; GO:0000976; GO:0001223; GO:0005160; GO:0043130; GO:0031625; GO:0008270","GO:0006919; GO:0097296; GO:0032924; GO:0030325; GO:0009653; GO:0030154; GO:0045216; GO:0071560; GO:0098586; GO:0048589; GO:0048701; GO:0048617; GO:0009880; GO:0007492; GO:0097191; GO:0007369; GO:0001947; GO:0006955; GO:0002520; GO:0001701; GO:0007254; GO:0070306; GO:0001889; GO:0000165; GO:0001707; GO:0043066; GO:1903243; GO:0030308; GO:0008285; GO:0051481; GO:0045599; GO:0010629; GO:0050728; GO:0061767; GO:0045668; GO:0033689; GO:0042177; GO:0000122; GO:0061045; GO:0038092; GO:0002076; GO:0001649; GO:0048340; GO:0060039; GO:0010694; GO:0030501; GO:0090263; GO:0030335; GO:0032332; GO:0051091; GO:0045893; GO:0010718; GO:1901203; GO:0051894; GO:0010628; GO:0032731; GO:1902895; GO:0045429; GO:0050927; GO:0042307; GO:0051496; GO:0045944; GO:0032916; GO:0031053; GO:0050821; GO:0051098; GO:0006355; GO:0050678; GO:0050776; GO:1902893; GO:0016202; GO:0006357; GO:0017015; GO:0032909; GO:0001666; GO:0023019; GO:0001501; GO:0007183; GO:0060395; GO:0001756; GO:0042110; GO:0030878; GO:0060290; GO:0007179; GO:0001657; GO:0042060","PTHR13703:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6769|UniProtKB=P84022","P00052; P06664"]
["Smad3 - phospho","Ser423/Ser425","SMAD3","52","rb",null,6,2.1,4,4,2.1,8,"# 0953",".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .FOXO., .HEPB., .HIF., .HIPPO., .IMFR., .IMU., .IMUF., .IMUR., .JNK., .MAPK., .MIG., .OP., .OPA., .OT., .PAC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TRASR., .VIR., .WNT.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3","activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; activin receptor signaling pathway; adrenal gland development; anatomical structure morphogenesis; cell differentiation; cell-cell junction organization; cellular response to transforming growth factor beta stimulus; cellular response to virus; developmental growth; embryonic cranial skeleton morphogenesis; embryonic foregut morphogenesis; embryonic pattern specification; endoderm development; extrinsic apoptotic signaling pathway; gastrulation; heart looping; immune response; immune system development; in utero embryonic development; JNK cascade; lens fiber cell differentiation; liver development; MAPK cascade; mesoderm formation; negative regulation of apoptotic process; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cytosolic calcium ion concentration; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of lung blood pressure; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of protein catabolic process; negative regulation of transcription by RNA polymerase II; negative regulation of wound healing; nodal signaling pathway; osteoblast development; osteoblast differentiation; paraxial mesoderm morphogenesis; pericardium development; positive regulation of alkaline phosphatase activity; positive regulation of bone mineralization; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of chondrocyte differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of extracellular matrix assembly; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of miRNA transcription; positive regulation of nitric oxide biosynthetic process; positive regulation of positive chemotaxis; positive regulation of protein import into nucleus; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta3 production; primary miRNA processing; protein stabilization; regulation of binding; regulation of DNA-templated transcription; regulation of epithelial cell proliferation; regulation of immune response; regulation of miRNA transcription; regulation of striated muscle tissue development; regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor beta2 production; response to hypoxia; signal transduction involved in regulation of gene expression; skeletal system development; SMAD protein complex assembly; SMAD protein signal transduction; somitogenesis; T cell activation; thyroid gland development; transdifferentiation; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing","beta-catenin binding; bHLH transcription factor binding; chromatin binding; chromatin DNA binding; cis-regulatory region sequence-specific DNA binding; collagen binding; co-SMAD binding; DEAD/H-box RNA helicase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity; double-stranded DNA binding; enzyme binding; identical protein binding; I-SMAD binding; metal ion binding; nuclear glucocorticoid receptor binding; nuclear mineralocorticoid receptor binding; nuclear receptor binding; phosphatase binding; promoter-specific chromatin binding; protein binding; protein homodimerization activity; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; sequence-specific DNA binding; SMAD binding; sterol response element binding; transcription cis-regulatory region binding; transcription coactivator binding; transforming growth factor beta receptor binding; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding","chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; nuclear inner membrane; nucleoplasm; nucleus; plasma membrane; protein-containing complex; receptor complex; SMAD protein complex; transcription regulator complex","TGF-beta / Smad signaling","SMAD family member 3","http://www.ncbi.nlm.nih.gov/gene/?term=4088","4088","17127","25631",null,"397260","711355","P84022","Q8BUN5","P84025","A0A8I3P2U7","P84024","A0A1D5Q1C9","GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0005637; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0043235; GO:0071141; GO:0005667","GO:0008013; GO:0043425; GO:0003682; GO:0031490; GO:0000987; GO:0005518; GO:0070410; GO:0017151; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0001217; GO:0003690; GO:0019899; GO:0042802; GO:0070411; GO:0046872; GO:0035259; GO:0031962; GO:0016922; GO:0019902; GO:1990841; GO:0005515; GO:0042803; GO:0019901; GO:0000978; GO:0000977; GO:0061629; GO:0070412; GO:0043565; GO:0046332; GO:0032810; GO:0000976; GO:0001223; GO:0005160; GO:0043130; GO:0031625; GO:0008270","GO:0006919; GO:0097296; GO:0032924; GO:0030325; GO:0009653; GO:0030154; GO:0045216; GO:0071560; GO:0098586; GO:0048589; GO:0048701; GO:0048617; GO:0009880; GO:0007492; GO:0097191; GO:0007369; GO:0001947; GO:0006955; GO:0002520; GO:0001701; GO:0007254; GO:0070306; GO:0001889; GO:0000165; GO:0001707; GO:0043066; GO:1903243; GO:0030308; GO:0008285; GO:0051481; GO:0045599; GO:0010629; GO:0050728; GO:0061767; GO:0045668; GO:0033689; GO:0042177; GO:0000122; GO:0061045; GO:0038092; GO:0002076; GO:0001649; GO:0048340; GO:0060039; GO:0010694; GO:0030501; GO:0090263; GO:0030335; GO:0032332; GO:0051091; GO:0045893; GO:0010718; GO:1901203; GO:0051894; GO:0010628; GO:0032731; GO:1902895; GO:0045429; GO:0050927; GO:0042307; GO:0051496; GO:0045944; GO:0032916; GO:0031053; GO:0050821; GO:0051098; GO:0006355; GO:0050678; GO:0050776; GO:1902893; GO:0016202; GO:0006357; GO:0017015; GO:0032909; GO:0001666; GO:0023019; GO:0001501; GO:0007183; GO:0060395; GO:0001756; GO:0042110; GO:0030878; GO:0060290; GO:0007179; GO:0001657; GO:0042060","PTHR13703:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6769|UniProtKB=P84022","P00052; P06664"]
["Smad4",null,"SMAD4","70","rb",null,1.1000000000000001,4,"n/a","n/a","n/a","n/a","# 2156",".BMP., .CANCER., .CANPTHW., .CCP., .CCY., .CML., .CP., .CRC., .CSP., .DEV., .DI., .FOXO., .HEPB., .HIF., .HIPPO., .IMUF., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .PAC., .RTK., .SREME., .ST., .TCD., .TGFB., .TMAT., .TRASR., .WNT.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway; Wnt signaling pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4","activin receptor signaling pathway; adrenal gland development; aging; anatomical structure morphogenesis; anterior/posterior pattern specification; atrioventricular canal development; atrioventricular valve formation; axon guidance; BMP signaling pathway; brainstem development; branching involved in ureteric bud morphogenesis; cardiac conduction system development; cardiac septum development; cell differentiation; cell population proliferation; cellular iron ion homeostasis; cellular response to BMP stimulus; cellular response to glucose stimulus; developmental growth; DNA-templated transcription; embryonic digit morphogenesis; endocardial cell differentiation; endoderm development; endothelial cell activation; epithelial cell migration; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; ERK1 and ERK2 cascade; female gonad development; female gonad morphogenesis; formation of anatomical boundary; gastrulation; gastrulation with mouth forming second; in utero embryonic development; interleukin-6-mediated signaling pathway; intracellular signal transduction; kidney development; left ventricular cardiac muscle tissue morphogenesis; male gonad development; mesoderm development; metanephric mesenchyme morphogenesis; negative regulation of cardiac muscle hypertrophy; negative regulation of cardiac myofibril assembly; negative regulation of cell death; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of ERK1 and ERK2 cascade; negative regulation of protein catabolic process; negative regulation of transcription by RNA polymerase II; nephrogenic mesenchyme morphogenesis; neural crest cell differentiation; neuron fate commitment; osteoblast differentiation; outflow tract septum morphogenesis; ovarian follicle development; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell proliferation involved in heart valve morphogenesis; positive regulation of DNA-templated transcription; positive regulation of epithelial to mesenchymal transition; positive regulation of follicle-stimulating hormone secretion; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 acetylation; positive regulation of luteinizing hormone secretion; positive regulation of miRNA transcription; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of binding; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of hair follicle development; regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor beta2 production; response to hypoxia; response to transforming growth factor beta; sebaceous gland development; secondary palate development; seminiferous tubule development; single fertilization; SMAD protein complex assembly; SMAD protein signal transduction; somite rostral/caudal axis specification; spermatogenesis; tissue morphogenesis; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; uterus development; ventricular septum morphogenesis; wound healing","chromatin binding; collagen binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; filamin binding; identical protein binding; I-SMAD binding; metal ion binding; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; R-SMAD binding; sequence-specific DNA binding; SMAD binding; sulfate binding; transcription cis-regulatory region binding; transcription coactivator binding","activin responsive factor complex; centrosome; chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription regulator complex; SMAD protein complex; transcription regulator complex","TGF-beta / Smad signaling","SMAD family member 4","http://www.ncbi.nlm.nih.gov/gene/?term=4089","4089","17128","50554",null,"397142",null,"Q13485","P97471","O70437","A0A8I3MN58","Q9GKQ9","A0A1D5QTT6","GO:0032444; GO:0005813; GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0005654; GO:0005634; GO:0032991; GO:0090575; GO:0071141; GO:0005667","GO:0003682; GO:0005518; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0031005; GO:0042802; GO:0070411; GO:0046872; GO:0005515; GO:0042803; GO:0000978; GO:0000977; GO:0061629; GO:0070412; GO:0043565; GO:0046332; GO:0043199; GO:0000976; GO:0001223","GO:0032924; GO:0030325; GO:0007568; GO:0009653; GO:0009952; GO:0036302; GO:0003190; GO:0007411; GO:0030509; GO:0003360; GO:0001658; GO:0003161; GO:0003279; GO:0030154; GO:0008283; GO:0006879; GO:0071773; GO:0071333; GO:0048589; GO:0006351; GO:0042733; GO:0060956; GO:0007492; GO:0042118; GO:0010631; GO:0001837; GO:0003198; GO:0070371; GO:0008585; GO:0061040; GO:0048859; GO:0007369; GO:0001702; GO:0001701; GO:0070102; GO:0035556; GO:0001822; GO:0003220; GO:0008584; GO:0007498; GO:0072133; GO:0010614; GO:1905305; GO:0060548; GO:0030308; GO:0008285; GO:0045892; GO:0070373; GO:0042177; GO:0000122; GO:0072134; GO:0014033; GO:0048663; GO:0001649; GO:0003148; GO:0001541; GO:0030513; GO:0010666; GO:0003251; GO:0045893; GO:0010718; GO:0046881; GO:0051571; GO:2000617; GO:0033686; GO:1902895; GO:0010862; GO:0060391; GO:0045944; GO:1901522; GO:0030511; GO:0051098; GO:0042127; GO:0006355; GO:0051797; GO:0006357; GO:0017015; GO:0032909; GO:0001666; GO:0071559; GO:0048733; GO:0062009; GO:0072520; GO:0007338; GO:0007183; GO:0060395; GO:0032525; GO:0007283; GO:0048729; GO:0006366; GO:0007179; GO:0060065; GO:0060412; GO:0042060","PTHR13703:SF63","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6770|UniProtKB=Q13485","P00052; P06664; P00057"]
["Smad5",null,"SMAD5","60","rb",null,2,4,7,2,8,8,"# 0954",".APO., .BMP., .CD., .CSP., .DEV., .OP., .OPA., .OT., .ST., .TGFB., .TRASR., .WNT.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway; Wnt signaling pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5","anatomical structure morphogenesis; BMP signaling pathway; bone development; cardiac conduction system development; cardiac muscle contraction; cartilage development; cell differentiation; cellular response to BMP stimulus; cellular response to organic cyclic compound; embryonic pattern specification; erythrocyte differentiation; germ cell development; Mullerian duct regression; negative regulation of apoptotic process; negative regulation of Fas signaling pathway; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; ossification; osteoblast fate commitment; positive regulation of DNA-templated transcription; positive regulation of osteoblast differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; protein phosphorylation; regulation of DNA-templated transcription; signal transduction; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway; ureteric bud development","DEAD/H-box RNA helicase binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; I-SMAD binding; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; ubiquitin protein ligase binding","chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; nucleoplasm; nucleus; protein-containing complex; SMAD protein complex; transcription regulator complex","TGF-beta / Smad signaling","SMAD family member 5","http://www.ncbi.nlm.nih.gov/gene/?term=4090","4090","17129","59328","481520",null,null,"Q99717","P97454","Q9R1V3","A0A8I3NW84","A0A286ZNF5","A0A1D5QTX9","GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0005654; GO:0005634; GO:0032991; GO:0071141; GO:0005667","GO:0017151; GO:0003677; GO:0000981; GO:0001227; GO:0070411; GO:0046872; GO:0005515; GO:0000978; GO:0000977; GO:1990837; GO:0031625","GO:0009653; GO:0030509; GO:0060348; GO:0003161; GO:0060048; GO:0051216; GO:0030154; GO:0071773; GO:0071407; GO:0009880; GO:0030218; GO:0007281; GO:0001880; GO:0043066; GO:1902045; GO:0010629; GO:0000122; GO:0001503; GO:0002051; GO:0045893; GO:0045669; GO:0045944; GO:1901522; GO:0006468; GO:0006355; GO:0007165; GO:0060395; GO:0007179; GO:0001657","PTHR13703:SF36","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6771|UniProtKB=Q99717","P00052; P06664; P00057"]
["Smad9 (Smad8)",null,"SMAD9","52","gt",null,2,7,8,8,8,8,"# 0916",".BMP., .CSP., .DEV., .OP., .OT., .TGFB., .TRASR.","TGF-beta signaling pathway; Gonadotropin releasing hormone receptor pathway","MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9","anatomical structure morphogenesis; BMP signaling pathway; cell differentiation; cellular response to BMP stimulus; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; regulation of DNA-templated transcription; SMAD protein signal transduction; transforming growth factor beta receptor signaling pathway","DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding","chromatin; cytoplasm; cytosol; heteromeric SMAD protein complex; nucleoplasm; nucleus; SMAD protein complex; transcription regulator complex","TGF-beta / Smad signaling","SMAD family member 9","http://www.ncbi.nlm.nih.gov/gene/?term=4093","4093","55994",null,"486006",null,null,"O15198","Q9JIW5","A0A0G2JY15","A0A8I3PZR5","A0A286ZTH9","A0A1D5QTT4","GO:0000785; GO:0005737; GO:0005829; GO:0071144; GO:0005654; GO:0005634; GO:0071141; GO:0005667","GO:0003677; GO:0000981; GO:0070411; GO:0046872; GO:0005515; GO:0000978","GO:0009653; GO:0030509; GO:0030154; GO:0071773; GO:1901522; GO:0006355; GO:0060395; GO:0007179","PTHR13703:SF41","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6774|UniProtKB=O15198","P00052; P06664"]
["SMC1 - phospho","Ser957","SMC1A","145","ms",null,7,4,"n/a","n/a","n/a","n/a","# 1031",".CCP., .CCY., .CD., .CP., .CSP., .DDR., .DREP., .OP.",null,"STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 1A","cell cycle; cell division; cellular response to DNA damage stimulus; chromosome organization; DNA repair; establishment of meiotic sister chromatid cohesion; establishment of mitotic sister chromatid cohesion; meiotic cell cycle; mitotic sister chromatid cohesion; mitotic sister chromatid segregation; mitotic spindle assembly; response to DNA damage checkpoint signaling; response to radiation; sister chromatid cohesion; somatic stem cell population maintenance","ATP binding; ATP hydrolysis activity; chromatin binding; DNA binding; mediator complex binding; nucleotide binding; protein binding; protein heterodimerization activity; RNA binding","chromosome; chromosome, centromeric region; cohesin complex; condensed nuclear chromosome; cytosol; DNA packaging complex; kinetochore; meiotic cohesin complex; mitotic spindle pole; nuclear matrix; nucleoplasm; nucleus","DNA damage","structural maintenance of chromosomes 1A","http://www.ncbi.nlm.nih.gov/gene/?term=8243","8243","24061",null,"480928",null,null,"Q14683","Q9CU62","F1LSS1","A0A8I3Q022",null,"A0A1D5QRI6","GO:0005694; GO:0000775; GO:0008278; GO:0000794; GO:0005829; GO:0044815; GO:0000776; GO:0030893; GO:0097431; GO:0016363; GO:0005654; GO:0005634","GO:0005524; GO:0016887; GO:0003682; GO:0003677; GO:0036033; GO:0000166; GO:0005515; GO:0046982; GO:0003723","GO:0007049; GO:0051301; GO:0006974; GO:0051276; GO:0006281; GO:0034089; GO:0034087; GO:0051321; GO:0007064; GO:0000070; GO:0090307; GO:0072423; GO:0009314; GO:0007062; GO:0035019","PTHR18937:SF170","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11111|UniProtKB=Q14683"]
["SMOC2",null,"SMOC2","47","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2113",".ANG., .CANCER., .CCP., .CCY., .CSP., .FGFR., .OP., .OPA., .RTK., .ST., .VEGFS.",null,"SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 2","extracellular matrix organization; positive regulation of angiogenesis; positive regulation of DNA biosynthetic process; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell migration; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of mitotic cell cycle; positive regulation of vascular endothelial growth factor signaling pathway; positive regulation of vascular wound healing","calcium ion binding; extracellular matrix binding; heparin binding; metal ion binding; protein binding","basement membrane; cell periphery; collagen-containing extracellular matrix; extracellular region; extracellular space",null,"SPARC related modular calcium binding 2","http://www.ncbi.nlm.nih.gov/gene/?term=64094","64094","64074",null,null,null,null,"Q9H3U7","Q8CD91","A0A0G2K0K9","A0A8I3MSK1","A0A287B457","A0A1D5RA35","GO:0005604; GO:0071944; GO:0062023; GO:0005576; GO:0005615","GO:0005509; GO:0050840; GO:0008201; GO:0046872; GO:0005515","GO:0030198; GO:0045766; GO:2000573; GO:2001028; GO:0010595; GO:0045743; GO:0045931; GO:1900748; GO:0035470","PTHR12352:SF21","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20323|UniProtKB=Q9H3U7"]
["Smoothened",null,"SMO","86","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1671",".APO., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DEV., .GPCR., .GPROT., .HHSP., .MIG., .OP., .OPA., .OT., .ST., .TRASR.","Hedgehog signaling pathway","SMOOTHENED HOMOLOG","alpha-tubulin acetylation; anterior/posterior pattern specification; apoptotic process; astrocyte activation; atrial septum morphogenesis; cell development; cell fate specification; cell population proliferation; cell surface receptor signaling pathway; cellular response to cholesterol; central nervous system development; central nervous system neuron differentiation; cerebellar cortex morphogenesis; cerebral cortex development; commissural neuron axon guidance; contact inhibition; dentate gyrus development; determination of left/right asymmetry in lateral mesoderm; determination of left/right symmetry; developmental growth; digestive tract development; dopaminergic neuron differentiation; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; embryonic organ development; epithelial cell differentiation; epithelial cell proliferation; epithelial-mesenchymal cell signaling; forebrain morphogenesis; G protein-coupled receptor signaling pathway; hair follicle development; hair follicle morphogenesis; heart looping; heart morphogenesis; homeostasis of number of cells within a tissue; in utero embryonic development; left/right axis specification; mammary gland epithelial cell differentiation; mesenchymal to epithelial transition involved in metanephric renal vesicle formation; midgut development; multicellular organism growth; myoblast migration; negative regulation of apoptotic process; negative regulation of DNA binding; negative regulation of DNA-templated transcription; negative regulation of epithelial cell differentiation; negative regulation of gene expression; negative regulation of hair follicle development; negative regulation of transcription by RNA polymerase II; neural crest cell migration; neuroblast proliferation; odontogenesis of dentin-containing tooth; ossification; osteoblast differentiation; pancreas morphogenesis; pattern specification process; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of hh target transcription factor activity; positive regulation of mesenchymal cell proliferation; positive regulation of multicellular organism growth; positive regulation of neuroblast proliferation; positive regulation of organ growth; positive regulation of protein import into nucleus; positive regulation of smoothened signaling pathway; positive regulation of transcription by RNA polymerase II; protein import into nucleus; protein localization to nucleus; protein stabilization; regulation of gene expression; regulation of heart morphogenesis; regulation of somatic stem cell population maintenance; signal transduction; skeletal muscle fiber development; smooth muscle tissue development; smoothened signaling pathway; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; smoothened signaling pathway involved in ventral spinal cord patterning; somite development; thalamus development; type B pancreatic cell development; vasculogenesis; ventral midline determination","G protein-coupled receptor activity; patched binding; protein binding; transmembrane signaling receptor activity","9+0 non-motile cilium; caveola; cell projection; centriole; ciliary membrane; ciliary tip; cilium; cytoplasm; dendrite; endocytic vesicle membrane; extracellular exosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; plasma membrane",null,"smoothened, frizzled class receptor","http://www.ncbi.nlm.nih.gov/gene/?term=6608","6608","319757",null,null,"100515110",null,"Q99835","P56726","A0A0G2JYI3","A0A8I3P5L7","F1SMQ3","F7H8W1","GO:0097731; GO:0005901; GO:0042995; GO:0005814; GO:0060170; GO:0097542; GO:0005929; GO:0005737; GO:0030425; GO:0030666; GO:0070062; GO:0005794; GO:0043231; GO:0016020; GO:0005886","GO:0004930; GO:0005113; GO:0005515; GO:0004888","GO:0071929; GO:0009952; GO:0006915; GO:0048143; GO:0060413; GO:0048468; GO:0001708; GO:0008283; GO:0007166; GO:0071397; GO:0007417; GO:0021953; GO:0021696; GO:0021987; GO:0071679; GO:0060242; GO:0021542; GO:0003140; GO:0007368; GO:0048589; GO:0048565; GO:0071542; GO:0021904; GO:0009953; GO:0048568; GO:0030855; GO:0050673; GO:0060684; GO:0048853; GO:0007186; GO:0001942; GO:0031069; GO:0001947; GO:0003007; GO:0048873; GO:0001701; GO:0070986; GO:0060644; GO:0072285; GO:0007494; GO:0035264; GO:0051451; GO:0043066; GO:0043392; GO:0045892; GO:0030857; GO:0010629; GO:0051799; GO:0000122; GO:0001755; GO:0007405; GO:0042475; GO:0001503; GO:0001649; GO:0061113; GO:0007389; GO:0090190; GO:0030335; GO:0008284; GO:0045893; GO:0050679; GO:0010628; GO:0007228; GO:0002053; GO:0040018; GO:0002052; GO:0046622; GO:0042307; GO:0045880; GO:0045944; GO:0006606; GO:0034504; GO:0050821; GO:0010468; GO:2000826; GO:1904672; GO:0007165; GO:0048741; GO:0048745; GO:0007224; GO:0021938; GO:0021910; GO:0061053; GO:0021794; GO:0003323; GO:0001570; GO:0007371","PTHR11309:SF35","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11119|UniProtKB=Q99835","P00025"]
["SOCS-1",null,"SOCS1","23","rb",null,4,4,"n/a","n/a","n/a","n/a","# 3242",".CSP., .IMUF., .INFM., .INS., .OP., .OPA., .OT., .RTK., .SREME., .ST., .STAT., .TCD., .TCR., .TMAT., .TRASR., .UBI.","JAK/STAT signaling pathway","SUPPRESSOR OF CYTOKINE SIGNALING 1","cellular response to amino acid stimulus; cytokine-mediated signaling pathway; fat cell differentiation; intracellular signal transduction; macrophage differentiation; negative regulation of CD8-positive, alpha-beta T cell differentiation; negative regulation of insulin receptor signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of signal transduction; negative regulation of tyrosine phosphorylation of STAT protein; phosphatidylinositol phosphate biosynthetic process; positive regulation of CD4-positive, alpha-beta T cell differentiation; positive regulation of regulatory T cell differentiation; protein ubiquitination; receptor signaling pathway via JAK-STAT; regulation of activation of Janus kinase activity; regulation of cytokine production; regulation of protein phosphorylation; regulation of receptor signaling pathway via JAK-STAT; regulation of tyrosine phosphorylation of STAT protein","1-phosphatidylinositol-3-kinase regulator activity; insulin-like growth factor receptor binding; kinase inhibitor activity; protein binding; protein kinase binding; protein kinase inhibitor activity","cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic vesicle; cytosol; nucleoplasm; nucleus; phosphatidylinositol 3-kinase complex","Wnt signaling","suppressor of cytokine signaling 1","http://www.ncbi.nlm.nih.gov/gene/?term=8651","8651","12703","252971",null,"100307052","711180","O15524","O35716","G3V6B4",null,"E7CR04","F7GGH3","GO:0005737; GO:0036464; GO:0031410; GO:0005829; GO:0005654; GO:0005634; GO:0005942","GO:0046935; GO:0005159; GO:0019210; GO:0005515; GO:0019901; GO:0004860","GO:0071230; GO:0019221; GO:0045444; GO:0035556; GO:0030225; GO:0043377; GO:0046627; GO:0046426; GO:0009968; GO:0042532; GO:0046854; GO:0043372; GO:0045591; GO:0016567; GO:0007259; GO:0010533; GO:0001817; GO:0001932; GO:0046425; GO:0042509","PTHR10155:SF4","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=19383|UniProtKB=O15524","P00038"]
["SOCS-3",null,"SOCS3","26","rb",null,1.1000000000000001,1,1,8,1.1000000000000001,8,"# 0404",".APO., .CD., .CSP., .IMFR., .IMUF., .IMUR., .INFG., .INS., .OP., .OPA., .OT., .RTK., .SREME., .ST., .STAT., .TNF., .UBI.","Interferon-gamma signaling pathway","SUPPRESSOR OF CYTOKINE SIGNALING 3","branching involved in labyrinthine layer morphogenesis; cell differentiation; cellular response to interleukin-17; cellular response to leukemia inhibitory factor; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of signal transduction; negative regulation of tyrosine phosphorylation of STAT protein; phosphatidylinositol phosphate biosynthetic process; placenta blood vessel development; positive regulation of cell differentiation; protein ubiquitination; regulation of protein phosphorylation; signal transduction","1-phosphatidylinositol-3-kinase regulator activity; miRNA binding; phosphotyrosine residue binding; protein binding; protein kinase inhibitor activity","cytosol; phosphatidylinositol 3-kinase complex","Immunology / inflammation","suppressor of cytokine signaling 3","http://www.ncbi.nlm.nih.gov/gene/?term=9021","9021","12702",null,null,null,null,"O14543","O35718",null,null,null,null,"GO:0005829; GO:0005942","GO:0046935; GO:0035198; GO:0001784; GO:0005515; GO:0004860","GO:0060670; GO:0030154; GO:0097398; GO:1990830; GO:0035556; GO:0043066; GO:0050728; GO:0046627; GO:0046426; GO:0009968; GO:0042532; GO:0046854; GO:0060674; GO:0045597; GO:0016567; GO:0001932; GO:0007165","PTHR10155:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=19391|UniProtKB=O14543","P00035"]
["Sox17",null,"SOX17","55","gt",null,1,8,"n/a","n/a","n/a","n/a","# 2865",".ANG., .CANCER., .CCP., .CP., .CSP., .DEV., .MIG., .OP., .OPA., .OT., .ST., .TRASR., .WNT.",null,"TRANSCRIPTION FACTOR SOX-17","anatomical structure morphogenesis; angiogenesis; cardiac cell fate determination; cardiogenic plate morphogenesis; cell differentiation; cell migration involved in gastrulation; cellular response to leukemia inhibitory factor; common bile duct development; embryonic foregut morphogenesis; embryonic heart tube development; embryonic heart tube morphogenesis; embryonic organ development; endocardial cell differentiation; endocardium formation; endoderm development; endoderm formation; endodermal cell differentiation; endodermal cell fate determination; endodermal cell fate specification; endodermal digestive tract morphogenesis; gallbladder development; gastrulation; gene expression; heart development; heart formation; heart looping; inner cell mass cellular morphogenesis; metanephros development; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth; negative regulation of Wnt signaling pathway; negative regulation of Wnt signaling pathway involved in heart development; outflow tract morphogenesis; positive regulation of DNA-templated transcription; positive regulation of endodermal cell differentiation; positive regulation of gene expression; positive regulation of protein catabolic process; positive regulation of stem cell differentiation; positive regulation of transcription by RNA polymerase II; protein destabilization; protein stabilization; regulation of cardiac cell fate specification; regulation of cell differentiation; regulation of DNA-templated transcription; regulation of embryonic development; regulation of stem cell division; regulation of stem cell proliferation; regulation of transcription by RNA polymerase II; rostrocaudal neural tube patterning; signal transduction involved in regulation of gene expression; spermatogenesis; stem cell differentiation; stem cell fate specification; ureter development; vasculogenesis; Wnt signaling pathway","beta-catenin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding","chromatin; nucleoplasm; nucleus; transcription regulator complex",null,"SRY-box transcription factor 17","http://www.ncbi.nlm.nih.gov/gene/?term=64321","64321","20671","312936",null,"100154087",null,"Q9H6I2","Q61473","G3V923","A0A8P0NPN0","F1RSI1",null,"GO:0000785; GO:0005654; GO:0005634; GO:0005667","GO:0008013; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0005515; GO:0000978; GO:0061629; GO:0043565; GO:0000976","GO:0009653; GO:0001525; GO:0060913; GO:0003142; GO:0030154; GO:0042074; GO:1990830; GO:0061009; GO:0048617; GO:0035050; GO:0003143; GO:0048568; GO:0060956; GO:0060214; GO:0007492; GO:0001706; GO:0035987; GO:0007493; GO:0001714; GO:0061031; GO:0061010; GO:0007369; GO:0010467; GO:0007507; GO:0060914; GO:0001947; GO:0001828; GO:0001656; GO:0090090; GO:0030308; GO:0030178; GO:0003308; GO:0003151; GO:0045893; GO:1903226; GO:0010628; GO:0045732; GO:2000738; GO:0045944; GO:0031648; GO:0050821; GO:2000043; GO:0045595; GO:0006355; GO:0045995; GO:2000035; GO:0072091; GO:0006357; GO:0021903; GO:0023019; GO:0007283; GO:0048863; GO:0048866; GO:0072189; GO:0001570; GO:0016055","PTHR10270:SF216","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18122|UniProtKB=Q9H6I2"]
["Sox2",null,"SOX2","35","rb",null,1,4,8,8,8,8,"# 0946",".CCP., .CP., .CSP., .DEV., .HIPPO., .MAPK., .OP., .OT., .RTK., .TRASR., .WNT.",null,"TRANSCRIPTION FACTOR SOX-2","adenohypophysis development; anatomical structure development; anatomical structure morphogenesis; cell differentiation; cell fate commitment; chromatin organization; endodermal cell fate specification; eye development; forebrain development; glial cell fate commitment; inner ear development; negative regulation of canonical Wnt signaling pathway; negative regulation of cell cycle G1/S phase transition; negative regulation of epithelial cell proliferation; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; neuronal stem cell population maintenance; osteoblast differentiation; pituitary gland development; positive regulation of cell differentiation; positive regulation of cell-cell adhesion; positive regulation of DNA-templated transcription; positive regulation of MAPK cascade; positive regulation of transcription by RNA polymerase II; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of DNA-templated transcription; regulation of gene expression; response to growth factor; response to wounding; somatic stem cell population maintenance; tissue regeneration","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; miRNA binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus; transcription regulator complex","Stem cell marker","SRY-box transcription factor 2","http://www.ncbi.nlm.nih.gov/gene/?term=6657","6657","20674","499593",null,null,null,"P48431","Q60I23","D4A543",null,null,null,"GO:0000785; GO:0005737; GO:0005829; GO:0016607; GO:0005654; GO:0005634; GO:0005667","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0035198; GO:0005515; GO:0000978; GO:0043565; GO:0000976","GO:0021984; GO:0048856; GO:0009653; GO:0030154; GO:0045165; GO:0006325; GO:0001714; GO:0001654; GO:0030900; GO:0021781; GO:0048839; GO:0090090; GO:1902807; GO:0050680; GO:0045665; GO:0000122; GO:0097150; GO:0001649; GO:0021983; GO:0045597; GO:0022409; GO:0045893; GO:0043410; GO:0045944; GO:0043281; GO:0006355; GO:0010468; GO:0070848; GO:0009611; GO:0035019; GO:0042246","PTHR10270:SF231","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11195|UniProtKB=P48431"]
["Sox6",null,"SOX6","90","rb",null,2,6,6,6,5,8,"# 1363",".OP., .OT., .TRASR.",null,"TRANSCRIPTION FACTOR SOX-6","brain development; cartilage condensation; cartilage development; cell differentiation; cell fate commitment; cellular response to transforming growth factor beta stimulus; central nervous system development; chondrocyte differentiation; muscle organ development; negative regulation of cardiac muscle cell differentiation; negative regulation of DNA-templated transcription; positive regulation of cartilage development; positive regulation of chondrocyte differentiation; positive regulation of mesenchymal stem cell differentiation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; spinal cord oligodendrocyte cell differentiation","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding","chromatin; cytoplasm; nucleoplasm; nucleus","Transcription factor","SRY-box transcription factor 6","http://www.ncbi.nlm.nih.gov/gene/?term=55553","55553","20679","293165",null,null,null,"P35712","P40645","A0A6I8PLH1","A0A8P0NV81",null,"F6XMX9","GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003677; GO:0003700; GO:0000981; GO:0001217; GO:0005515; GO:0042803; GO:0000978; GO:0000976","GO:0007420; GO:0001502; GO:0051216; GO:0030154; GO:0045165; GO:0071560; GO:0007417; GO:0002062; GO:0007517; GO:2000726; GO:0045892; GO:0061036; GO:0032332; GO:2000741; GO:0006355; GO:0006357; GO:0021529","PTHR45789:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16421|UniProtKB=P35712"]
["Sox9",null,"SOX9","65-56","rb",null,2,6,6,6,6,6,"# 1302",".APO., .cAMP., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .EGFR., .GPCR., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR., .WNT.",null,"TRANSCRIPTION FACTOR SOX-9","anterior head development; aortic valve morphogenesis; apoptotic process; astrocyte fate commitment; bone mineralization; branching involved in ureteric bud morphogenesis; bronchus cartilage development; cAMP-mediated signaling; canonical Wnt signaling pathway; cartilage condensation; cartilage development; cell differentiation; cell fate commitment; cell fate specification; cell population proliferation; cell proliferation involved in heart morphogenesis; cell-cell adhesion; cellular response to BMP stimulus; cellular response to epidermal growth factor stimulus; cellular response to heparin; cellular response to interleukin-1; cellular response to mechanical stimulus; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; central nervous system development; chondrocyte development; chondrocyte differentiation; chondrocyte differentiation involved in endochondral bone morphogenesis; chondrocyte hypertrophy; chromatin remodeling; cochlea morphogenesis; cytoskeleton organization; endocardial cushion morphogenesis; endochondral bone morphogenesis; endocrine pancreas development; epidermal growth factor receptor signaling pathway; epithelial cell proliferation; epithelial cell proliferation involved in prostatic bud elongation; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; ERK1 and ERK2 cascade; extracellular matrix assembly; extracellular matrix organization; gene expression; glandular epithelial cell differentiation; glial cell fate specification; growth plate cartilage chondrocyte growth; hair follicle development; Harderian gland development; heart development; heart valve development; heart valve formation; heart valve morphogenesis; homeostasis of number of cells within a tissue; intestinal epithelial cell differentiation; intestinal epithelial structure maintenance; intrahepatic bile duct development; lacrimal gland development; limb bud formation; lung epithelial cell differentiation; lung smooth muscle development; male germ-line sex determination; male gonad development; male sex determination; mammary gland development; mesenchymal cell apoptotic process; mesenchymal cell proliferation; metanephric nephron tubule formation; metanephric tubule development; morphogenesis of a branching epithelium; morphogenesis of an epithelium; negative regulation of apoptotic process; negative regulation of beta-catenin-TCF complex assembly; negative regulation of biomineral tissue development; negative regulation of bone mineralization; negative regulation of canonical Wnt signaling pathway; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of epithelial cell differentiation; negative regulation of epithelial cell proliferation; negative regulation of fatty acid oxidation; negative regulation of gene expression; negative regulation of immune system process; negative regulation of mesenchymal cell apoptotic process; negative regulation of miRNA transcription; negative regulation of myoblast differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of transcription by RNA polymerase II; neural crest cell development; neural crest cell fate specification; neuron fate specification; Notch signaling pathway; notochord development; nucleosome assembly; oligodendrocyte differentiation; ossification; otic vesicle development; otic vesicle formation; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cartilage development; positive regulation of cell population proliferation; positive regulation of cell proliferation involved in heart morphogenesis; positive regulation of chondrocyte differentiation; positive regulation of chondrocyte proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell migration; positive regulation of epithelial cell proliferation; positive regulation of extracellular matrix assembly; positive regulation of gene expression; positive regulation of kidney development; positive regulation of male gonad development; positive regulation of mesenchymal cell proliferation; positive regulation of mesenchymal stem cell differentiation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein catabolic process; positive regulation of protein phosphorylation; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; prostate gland development; prostate gland morphogenesis; protein kinase B signaling; protein localization to nucleus; protein phosphorylation; protein-containing complex assembly; regulation of apoptotic process; regulation of branching involved in lung morphogenesis; regulation of cell adhesion; regulation of cell cycle process; regulation of cell differentiation; regulation of cell population proliferation; regulation of cell proliferation involved in tissue homeostasis; regulation of epithelial cell proliferation involved in lung morphogenesis; regulation of gene expression; regulation of transcription by RNA polymerase II; renal vesicle induction; response to fatty acid; response to organic cyclic compound; retina development in camera-type eye; retinal rod cell differentiation; Sertoli cell development; Sertoli cell differentiation; signal transduction; skeletal system development; somatic stem cell population maintenance; spermatogenesis; stem cell proliferation; tissue homeostasis; trachea cartilage development; transcription by RNA polymerase II; type I pneumocyte differentiation; ureter development; ureter morphogenesis; ureter smooth muscle cell differentiation; ureter urothelium development","beta-catenin binding; bHLH transcription factor binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; pre-mRNA intronic binding; protein binding; protein kinase A catalytic subunit binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","chromatin; nucleoplasm; nucleus; protein-containing complex; transcription regulator complex","Stem cell marker","SRY-box transcription factor 9","http://www.ncbi.nlm.nih.gov/gene/?term=6662","6662","20682","140586",null,"396840",null,"P48436","Q04887","F1LYL9","A0A8I3P9I2","F1RV30",null,"GO:0000785; GO:0005654; GO:0005634; GO:0032991; GO:0005667","GO:0008013; GO:0043425; GO:0003682; GO:0000987; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0097157; GO:0005515; GO:0034236; GO:0000978; GO:0043565; GO:1990837; GO:0000976","GO:0097065; GO:0003180; GO:0006915; GO:0060018; GO:0030282; GO:0001658; GO:0060532; GO:0019933; GO:0060070; GO:0001502; GO:0051216; GO:0030154; GO:0045165; GO:0001708; GO:0008283; GO:0061323; GO:0098609; GO:0071773; GO:0071364; GO:0071504; GO:0071347; GO:0071260; GO:0071300; GO:0071560; GO:0007417; GO:0002063; GO:0002062; GO:0003413; GO:0003415; GO:0006338; GO:0090103; GO:0007010; GO:0003203; GO:0060350; GO:0031018; GO:0007173; GO:0050673; GO:0060517; GO:0001837; GO:0060441; GO:0070371; GO:0085029; GO:0030198; GO:0010467; GO:0002067; GO:0021780; GO:0003430; GO:0001942; GO:0070384; GO:0007507; GO:0003170; GO:0003188; GO:0003179; GO:0048873; GO:0060575; GO:0060729; GO:0035622; GO:0032808; GO:0060174; GO:0060487; GO:0061145; GO:0019100; GO:0008584; GO:0030238; GO:0030879; GO:0097152; GO:0010463; GO:0072289; GO:0072170; GO:0061138; GO:0002009; GO:0043066; GO:1904864; GO:0070168; GO:0030502; GO:0090090; GO:0032331; GO:0045892; GO:0030857; GO:0050680; GO:0046322; GO:0010629; GO:0002683; GO:2001054; GO:1902894; GO:0045662; GO:0030279; GO:0045668; GO:0046533; GO:0000122; GO:0014032; GO:0014036; GO:0048665; GO:0007219; GO:0030903; GO:0006334; GO:0048709; GO:0001503; GO:0071599; GO:0030916; GO:0090190; GO:0061036; GO:0008284; GO:2000138; GO:0032332; GO:1902732; GO:0045893; GO:0030858; GO:0010634; GO:0050679; GO:1901203; GO:0010628; GO:0090184; GO:2000020; GO:0002053; GO:2000741; GO:0014068; GO:0045732; GO:0001934; GO:2000648; GO:0045944; GO:0030850; GO:0060512; GO:0043491; GO:0034504; GO:0006468; GO:0065003; GO:0042981; GO:0061046; GO:0030155; GO:0010564; GO:0045595; GO:0042127; GO:0060784; GO:2000794; GO:0010468; GO:0006357; GO:0072034; GO:0070542; GO:0014070; GO:0060041; GO:0060221; GO:0060009; GO:0060008; GO:0007165; GO:0001501; GO:0035019; GO:0007283; GO:0072089; GO:0001894; GO:0060534; GO:0006366; GO:0060509; GO:0072189; GO:0072197; GO:0072193; GO:0072190","PTHR45803:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11204|UniProtKB=P48436"]
["SP1",null,"SP1","90","rb",null,6,4,8,8,5,4,"# 1550",".ANG., .APH., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .DEV., .DI., .HUNT., .IMUR., .INS., .OP., .OPA., .OT., .OXS., .SREME., .TGFB., .TRASR., .VIR.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Huntington disease","TRANSCRIPTION FACTOR SP1","cellular response to estrogen stimulus; cellular response to insulin stimulus; cellular response to wortmannin; cellular response to zinc ion starvation; positive regulation by host of viral transcription; positive regulation of amyloid-beta formation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of hydrogen sulfide biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial cell proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to hydroperoxide; rhythmic process","bHLH transcription factor binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; double-stranded DNA binding; histone acetyltransferase binding; histone deacetylase binding; HMG box domain binding; identical protein binding; metal ion binding; molecular adaptor activity; protein binding; protein C-terminus binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coregulator binding","chromatin; cytoplasm; euchromatin; nucleoplasm; nucleus; protein-DNA complex; transcription repressor complex","Chromatin regulation / epigenetics","Sp1 transcription factor","http://www.ncbi.nlm.nih.gov/gene/?term=6667","6667","20683","24790",null,"396575",null,"P08047","O89090","Q01714","A0A8P0SC80","A0A286ZZJ6","A0A5F8AL74","GO:0000785; GO:0005737; GO:0000791; GO:0005654; GO:0005634; GO:0032993; GO:0017053","GO:0043425; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0003690; GO:0035035; GO:0042826; GO:0071837; GO:0042802; GO:0046872; GO:0060090; GO:0005515; GO:0008022; GO:0042803; GO:0000978; GO:0000977; GO:0061629; GO:0043565; GO:1990837; GO:0000976; GO:0001221","GO:0071391; GO:0032869; GO:1904568; GO:0034224; GO:0043923; GO:1902004; GO:0045766; GO:0043536; GO:0045893; GO:0010628; GO:1904828; GO:0045944; GO:1905564; GO:0006355; GO:0006357; GO:0033194; GO:0048511","PTHR23235:SF16","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11205|UniProtKB=P08047","P06959; P06664; P00029"]
["SPARC",null,"SPARC","42","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2807",".ANG., .CANCER., .CCP., .CP., .OP.",null,"SPARC","anatomical structure development; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; positive regulation of endothelial cell migration; regulation of cell morphogenesis","calcium ion binding; collagen binding; extracellular matrix binding; extracellular matrix structural constituent; metal ion binding; protein binding","basement membrane; cell surface; cellular anatomical entity; collagen-containing extracellular matrix; cytoplasm; endocytic vesicle lumen; extracellular region; extracellular space; intracellular membrane-bounded organelle; mitochondrion; nuclear matrix; plasma membrane; platelet alpha granule; platelet alpha granule lumen; platelet alpha granule membrane",null,"secreted protein acidic and cysteine rich","http://www.ncbi.nlm.nih.gov/gene/?term=6678","6678","20692",null,null,null,null,"P09486","P07214","A0A8I5ZWN9","A0A8I3MV86",null,null,"GO:0005604; GO:0009986; GO:0110165; GO:0062023; GO:0005737; GO:0071682; GO:0005576; GO:0005615; GO:0043231; GO:0005739; GO:0016363; GO:0005886; GO:0031091; GO:0031093; GO:0031092","GO:0005509; GO:0005518; GO:0050840; GO:0005201; GO:0046872; GO:0005515","GO:0048856; GO:0016525; GO:0001937; GO:0010595; GO:0022604","PTHR13866:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11219|UniProtKB=P09486"]
["Spectrin alpha/beta",null,"SPTA1, SPTB","280, 250","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0910",".APO., .CD., .CSP., .IMUF., .TCR.",null,"SPECTRIN ALPHA CHAIN, ERYTHROCYTIC 1; SPECTRIN BETA CHAIN, ERYTHROCYTIC","actin cytoskeleton organization; actin filament capping; actin filament organization; hemopoiesis; lymphocyte homeostasis; plasma membrane organization; porphyrin-containing compound biosynthetic process; positive regulation of protein binding; positive regulation of T cell proliferation; regulation of cell shape; modification of postsynaptic actin cytoskeleton","actin binding; actin filament binding; calcium ion binding; metal ion binding; protein binding; structural constituent of cytoskeleton; ankyrin binding","actin cytoskeleton; axon; cell cortex; cell junction; cell projection; cortical actin cytoskeleton; cortical cytoskeleton; cuticular plate; cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; membrane; plasma membrane; spectrin; spectrin-associated cytoskeleton; cell periphery; glutamatergic synapse; postsynapse; protein-containing complex",null,"spectrin alpha, erythrocytic 1; spectrin beta, erythrocytic","http://www.ncbi.nlm.nih.gov/gene/?term=6708, http://www.ncbi.nlm.nih.gov/gene/?term=6710","6708, 6710","20739, NA","NA, 314251",null,null,null,"P02549, P11277","P08032, E9Q397","A0A8J8Y4Y9, A0A140UHX6","A0A8P0NDL2, A0A8P0SK94","A0A5G2Q8C3, A0A287A113","A0A5F7ZR12, A0A1D5Q6B2","GO:0015629; GO:0030424; GO:0005938; GO:0030054; GO:0042995; GO:0030864; GO:0030863; GO:0032437; GO:0005737; GO:0009898; GO:0005856; GO:0005829; GO:0016020; GO:0005886; GO:0008091; GO:0014731; GO:0071944; GO:0098978; GO:0098794; GO:0032991","GO:0003779; GO:0051015; GO:0005509; GO:0046872; GO:0005515; GO:0005200; GO:0030506","GO:0030036; GO:0051693; GO:0007015; GO:0030097; GO:0002260; GO:0007009; GO:0006779; GO:0032092; GO:0042102; GO:0008360; GO:0098885","PTHR11915:SF431; PTHR11915:SF248","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11272|UniProtKB=P02549; http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11274|UniProtKB=P11277"]
["SPON2",null,"SPON2","36","rb",null,2,6,6,6,7,7,"# 1389",".IIR., .IMU., .IMUR., .OP., .OT., .TRASR., .VIR.",null,"SPONDIN-2","cell adhesion; cellular response to lipopolysaccharide; defense response to bacterium; defense response to fungus; defense response to virus; immune system process; induction of bacterial agglutination; innate immune response; mast cell mediated immunity; opsonization; positive regulation of interleukin-6 production; positive regulation of macrophage cytokine production; positive regulation of tumor necrosis factor production; response to lipopolysaccharide","antigen binding; lipopolysaccharide binding; metal ion binding; protein binding","extracellular exosome; extracellular matrix; extracellular region; extracellular space","Adhesion","spondin 2","http://www.ncbi.nlm.nih.gov/gene/?term=10417","10417","100689","171569",null,null,null,"Q9BUD6","Q8BMS2","Q9WV75",null,null,null,"GO:0070062; GO:0031012; GO:0005576; GO:0005615","GO:0003823; GO:0001530; GO:0046872; GO:0005515","GO:0007155; GO:0071222; GO:0042742; GO:0050832; GO:0051607; GO:0002376; GO:0043152; GO:0045087; GO:0002448; GO:0008228; GO:0032755; GO:0060907; GO:0032760; GO:0032496","PTHR11311:SF15","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11253|UniProtKB=Q9BUD6"]
["SPRED1",null,"SPRED1","50","rb",null,1,2,1,6,7,7,"# 0389",".ANG., .CANCER., .CD., .CSP., .DDR., .DEV., .MAPK., .OP., .OPA., .P53S., .RTK., .ST., .TGFB.",null,"SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 1","negative regulation of angiogenesis; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of lens fiber cell differentiation; negative regulation of MAPK cascade; negative regulation of peptidyl-threonine phosphorylation; negative regulation of protein kinase activity; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of MAPK cascade; regulation of protein deacetylation; regulation of signal transduction; vasculogenesis involved in coronary vascular morphogenesis","phosphatase binding; protein binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; stem cell factor receptor binding","caveola; cytoplasmic vesicle; cytosol; membrane; nucleoplasm; nucleus; plasma membrane","MAPK signaling","sprouty related EVH1 domain containing 1","http://www.ncbi.nlm.nih.gov/gene/?term=161742","161742","114715",null,"487485",null,null,"Q7Z699","Q924S8",null,"A0A8I3PN43",null,"A0A5K1TVL6","GO:0005901; GO:0031410; GO:0005829; GO:0016020; GO:0005654; GO:0005634; GO:0005886","GO:0019902; GO:0005515; GO:0019901; GO:0030291; GO:0005173","GO:0016525; GO:0090051; GO:0010719; GO:0070373; GO:1902747; GO:0043409; GO:0010801; GO:0006469; GO:0030512; GO:0043517; GO:0043408; GO:0090311; GO:0009966; GO:0060979","PTHR11202:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=20249|UniProtKB=Q7Z699"]
["SPRED2",null,"SPRED2","48","rb",null,2,2,1,1,1,1,"# 0388",".CD., .CSP., .DDR., .DEV., .MAPK., .OPA., .P53S., .RTK., .ST., .TGFB.",null,"SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2","negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of lens fiber cell differentiation; negative regulation of MAPK cascade; negative regulation of peptidyl-threonine phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of protein deacetylation; regulation of signal transduction","protein binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; stem cell factor receptor binding","cytoplasm; cytoplasmic vesicle; cytosol; membrane; plasma membrane; transport vesicle membrane","MAPK signaling","sprouty related EVH1 domain containing 2","http://www.ncbi.nlm.nih.gov/gene/?term=200734","200734","114716","305539","481397",null,null,"Q7Z698","Q924S7","Q3C2P8","A0A8I3P9R1","A0A286ZNR4","A0A1D5QDM1","GO:0005737; GO:0031410; GO:0005829; GO:0016020; GO:0005886; GO:0030658","GO:0005515; GO:0019901; GO:0030291; GO:0005173","GO:0010719; GO:0070373; GO:1902747; GO:0043409; GO:0010801; GO:0030512; GO:0043517; GO:0090311; GO:0009966","PTHR11202:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17722|UniProtKB=Q7Z698"]
["SPRY1 (Spry-1, Sprouty 1)",null,"SPRY1","35","rb",null,2,4,7,7,2.1,2,"# 0415",".CCP., .CP., .CSP., .DEV., .EGFR., .FGFR., .MAPK., .OP., .OPA., .RAS., .RTK., .ST., .TGFB.","FGF signaling pathway; EGF receptor signaling pathway","PROTEIN SPROUTY HOMOLOG 1","animal organ development; bud elongation involved in lung branching; epithelial to mesenchymal transition involved in cardiac fibroblast development; ERK1 and ERK2 cascade; establishment of mitotic spindle orientation; metanephros development; negative regulation of cell population proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of GTPase activity; negative regulation of lens fiber cell differentiation; negative regulation of MAP kinase activity; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of Ras protein signal transduction; negative regulation of transforming growth factor beta receptor signaling pathway; organ induction; regulation of signal transduction; ureteric bud development","protein binding","cytoplasm; cytosol; Golgi apparatus; membrane; nucleoplasm; plasma membrane","MAPK signaling","sprouty RTK signaling antagonist 1","http://www.ncbi.nlm.nih.gov/gene/?term=10252","10252","24063",null,null,"100623283",null,"O43609","Q9QXV9","B5DFH3",null,"F1RRA2","A0A5F7ZCK3","GO:0005737; GO:0005829; GO:0005794; GO:0016020; GO:0005654; GO:0005886","GO:0005515","GO:0048513; GO:0060449; GO:0060940; GO:0070371; GO:0000132; GO:0001656; GO:0008285; GO:0010719; GO:0070373; GO:0040037; GO:0034260; GO:1902747; GO:0043407; GO:0051387; GO:0046580; GO:0030512; GO:0001759; GO:0009966; GO:0001657","PTHR12365:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11269|UniProtKB=O43609","P00021; P00018"]
["SPRY2 (Protein sprouty homolog 2)",null,"SPRY2","40-35","rb",null,2,2,6,2,1,1,"# 0342",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .EGFR., .FGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TGFB., .TRASR., .UBI., .VEGFS.","FGF signaling pathway; EGF receptor signaling pathway","PROTEIN SPROUTY HOMOLOG 2","animal organ development; branching morphogenesis of an epithelial tube; bud elongation involved in lung branching; cell fate commitment; cellular response to leukemia inhibitory factor; cellular response to vascular endothelial growth factor stimulus; ERK1 and ERK2 cascade; establishment of mitotic spindle orientation; fibroblast growth factor receptor signaling pathway; inner ear morphogenesis; lung development; lung growth; lung morphogenesis; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of cell projection organization; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of GTPase activity; negative regulation of lens fiber cell differentiation; negative regulation of MAP kinase activity; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of peptidyl-threonine phosphorylation; negative regulation of protein ubiquitination; negative regulation of Ras protein signal transduction; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of vascular endothelial growth factor signaling pathway; positive regulation of cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling; regulation of signal transduction; respiratory system development; sensory perception of sound","protein binding; protein kinase binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase inhibitor activity","actin cytoskeleton; cell projection; cytoplasm; cytoskeleton; cytosol; membrane; microtubule; microtubule cytoskeleton; microtubule end; nucleus; plasma membrane; ruffle membrane","EGFR signaling","sprouty RTK signaling antagonist 2","http://www.ncbi.nlm.nih.gov/gene/?term=10253","10253","24064","306141","485504","100157266","702103","O43597","Q9QXV8","Q5HZA2","A0A8I3PYH2","F1RP67","G7NJH1","GO:0015629; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0016020; GO:0005874; GO:0015630; GO:1990752; GO:0005634; GO:0005886; GO:0032587","GO:0005515; GO:0019901; GO:0043539; GO:0030291","GO:0048513; GO:0048754; GO:0060449; GO:0045165; GO:1990830; GO:0035924; GO:0070371; GO:0000132; GO:0008543; GO:0042472; GO:0030324; GO:0060437; GO:0060425; GO:0016525; GO:0043066; GO:0008285; GO:0031345; GO:0010719; GO:0070373; GO:0040037; GO:0034260; GO:1902747; GO:0043407; GO:0051387; GO:0010801; GO:0031397; GO:0046580; GO:0030512; GO:1900747; GO:0030335; GO:0070374; GO:0010628; GO:0033138; GO:0051897; GO:0009966; GO:0060541; GO:0007605","PTHR12365:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11270|UniProtKB=O43597","P00021; P00018"]
["SPRY3 (Spry-3, Sprouty 3)",null,"SPRY3","31","rb",null,2,1,1,6,1,2,"# 1723",".CSP., .EGFR., .FGFR., .MAPK., .OPA., .RAS., .RTK., .ST.","FGF signaling pathway; EGF receptor signaling pathway","PROTEIN SPROUTY HOMOLOG 3","animal organ development; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of neuron projection arborization; negative regulation of Ras protein signal transduction; nervous system development; regulation of signal transduction","molecular_function; protein binding","cytoplasm; cytosol; membrane","EGFR signaling","sprouty RTK signaling antagonist 3","http://www.ncbi.nlm.nih.gov/gene/?term=10251","10251",null,"498159",null,null,null,"O43610",null,"B5DF90",null,null,null,"GO:0005737; GO:0005829; GO:0016020","GO:0003674; GO:0005515","GO:0048513; GO:0070373; GO:0040037; GO:0043407; GO:0043409; GO:0150013; GO:0046580; GO:0007399; GO:0009966","PTHR12365:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11271|UniProtKB=O43610","P00021; P00018"]
["SPRY4 (Spry-4, Sprouty 4)",null,"SPRY4","32","rb",null,2,6,3,3,3,3,"# 0420",".CSP., .EGFR., .FGFR., .MAPK., .OPA., .RAS., .RTK., .ST.","FGF signaling pathway; EGF receptor signaling pathway","PROTEIN SPROUTY HOMOLOG 4","animal organ development; cellular response to leukemia inhibitory factor; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of Ras protein signal transduction; negative regulation of substrate adhesion-dependent cell spreading; regulation of signal transduction","protein binding; protein kinase inhibitor activity","cell projection; cytoplasm; cytosol; focal adhesion; membrane; plasma membrane; ruffle membrane","MAPK signaling","sprouty RTK signaling antagonist 4","http://www.ncbi.nlm.nih.gov/gene/?term=81848","81848","24066","291610",null,null,"705836","Q9C004","Q9WTP2","D3ZJA3",null,null,"F7ALK4","GO:0042995; GO:0005737; GO:0005829; GO:0005925; GO:0016020; GO:0005886; GO:0032587","GO:0005515; GO:0004860","GO:0048513; GO:1990830; GO:0040037; GO:0043407; GO:0046580; GO:1900025; GO:0009966","PTHR12365:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=15533|UniProtKB=Q9C004","P00021; P00018"]
["Src",null,"SRC","60","rb",null,2,1,1,1,2,2,"# 0571",".ANG., .APH., .APO., .BLC., .CADH., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .ErbB., .GPCR., .GPROT., .HEPB., .HIF., .HIPPO., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PARK., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .VEGFS., .VIR., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; Integrin signalling pathway; Angiogenesis; Parkinson disease","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","activation of protein kinase B activity; adherens junction organization; angiotensin-activated signaling pathway involved in heart process; bone resorption; brain development; branching involved in mammary gland duct morphogenesis; cell adhesion; cell cycle; cell differentiation; cell migration; cell population proliferation; cell-cell adhesion; cellular response to angiotensin; cellular response to fatty acid; cellular response to fluid shear stress; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to lipopolysaccharide; cellular response to peptide hormone stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to progesterone stimulus; cellular response to prolactin; cellular response to reactive oxygen species; cellular response to transforming growth factor beta stimulus; DNA biosynthetic process; entry of bacterium into host cell; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; focal adhesion assembly; forebrain development; immune system process; innate immune response; integrin-mediated signaling pathway; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; intracellular signal transduction; learning or memory; leukocyte migration; macroautophagy; myoblast proliferation; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of focal adhesion assembly; negative regulation of inflammatory response to antigenic stimulus; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of mitochondrial depolarization; negative regulation of protein-containing complex assembly; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; neurotrophin TRK receptor signaling pathway; odontogenesis; oogenesis; osteoclast development; peptidyl-serine phosphorylation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet activation; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt signaling pathway; positive regulation of cell adhesion; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of cytokine production; positive regulation of dephosphorylation; positive regulation of DNA biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose metabolic process; positive regulation of hippo signaling; positive regulation of insulin receptor signaling pathway; positive regulation of integrin activation; positive regulation of intracellular signal transduction; positive regulation of lamellipodium morphogenesis; positive regulation of male germ cell proliferation; positive regulation of MAP kinase activity; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of Notch signaling pathway; positive regulation of ovarian follicle development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of platelet-derived growth factor receptor-beta signaling pathway; positive regulation of podosome assembly; positive regulation of protein autophosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of protein processing; positive regulation of protein serine/threonine kinase activity; positive regulation of protein transport; positive regulation of Ras protein signal transduction; positive regulation of small GTPase mediated signal transduction; positive regulation of smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; primary ovarian follicle growth; progesterone receptor signaling pathway; protein autophosphorylation; protein destabilization; protein phosphorylation; regulation of bone resorption; regulation of caveolin-mediated endocytosis; regulation of cell projection assembly; regulation of cell-cell adhesion; regulation of early endosome to late endosome transport; regulation of epithelial cell migration; regulation of intracellular estrogen receptor signaling pathway; regulation of postsynaptic neurotransmitter receptor activity; regulation of protein binding; regulation of vascular permeability; response to acidic pH; response to electrical stimulus; response to fatty acid; response to hydrogen peroxide; response to interleukin-1; response to mechanical stimulus; response to mineralocorticoid; response to nutrient levels; response to virus; response to xenobiotic stimulus; signal complex assembly; signal transduction; skeletal muscle cell proliferation; spermatogenesis; stimulatory C-type lectin receptor signaling pathway; stress fiber assembly; substrate adhesion-dependent cell spreading; T cell costimulation; transcytosis; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; uterus development; vascular endothelial growth factor receptor signaling pathway","ATP binding; ATPase binding; BMP receptor binding; cadherin binding; cell adhesion molecule binding; connexin binding; enzyme binding; ephrin receptor binding; growth factor receptor binding; heme binding; insulin receptor binding; integrin binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nuclear estrogen receptor binding; nucleotide binding; phospholipase activator activity; phospholipase binding; phosphoprotein binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein kinase C binding; protein tyrosine kinase activity; protein-containing complex binding; scaffold protein binding; SH2 domain binding; signaling receptor binding; transferase activity; transmembrane transporter binding","actin filament; anchoring junction; caveola; cell junction; cytoplasm; cytoskeleton; cytosol; dendritic filopodium; dendritic growth cone; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; glutamatergic synapse; late endosome; lysosome; membrane; membrane raft; mitochondrial inner membrane; mitochondrion; neuron projection; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome; postsynaptic density; postsynaptic specialization, intracellular component; ruffle membrane; synaptic membrane","Tyrosine kinase / adaptor","SRC proto-oncogene, non-receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=6714","6714","20779","83805",null,null,null,"P12931","P05480","Q9WUD9","A0A8I3Q3C2","A0A5G2QDX5","F7FWN4","GO:0005884; GO:0070161; GO:0005901; GO:0030054; GO:0005737; GO:0005856; GO:0005829; GO:1902737; GO:0044294; GO:0070062; GO:0031234; GO:0005925; GO:0098978; GO:0005770; GO:0005764; GO:0016020; GO:0045121; GO:0005743; GO:0005739; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0002102; GO:0014069; GO:0099091; GO:0032587; GO:0097060","GO:0005524; GO:0051117; GO:0070700; GO:0045296; GO:0050839; GO:0071253; GO:0019899; GO:0046875; GO:0070851; GO:0020037; GO:0005158; GO:0005178; GO:0016301; GO:0004715; GO:0030331; GO:0000166; GO:0016004; GO:0043274; GO:0051219; GO:0005515; GO:0008022; GO:0019904; GO:0004672; GO:0019901; GO:0005080; GO:0004713; GO:0044877; GO:0097110; GO:0042169; GO:0005102; GO:0016740; GO:0044325","GO:0032148; GO:0034332; GO:0086098; GO:0045453; GO:0007420; GO:0060444; GO:0007155; GO:0007049; GO:0030154; GO:0016477; GO:0008283; GO:0098609; GO:1904385; GO:0071398; GO:0071498; GO:0070301; GO:0071456; GO:0032869; GO:0071222; GO:0071375; GO:0036120; GO:0071393; GO:1990646; GO:0034614; GO:0071560; GO:0071897; GO:0035635; GO:0048013; GO:0007173; GO:0038128; GO:0038096; GO:0048041; GO:0030900; GO:0002376; GO:0045087; GO:0007229; GO:0070102; GO:0060576; GO:0035556; GO:0007611; GO:0050900; GO:0016236; GO:0051450; GO:2000811; GO:0043066; GO:0043154; GO:0045892; GO:2001237; GO:0051895; GO:0002862; GO:2001243; GO:0051902; GO:0031333; GO:0051974; GO:0032211; GO:0048011; GO:0042476; GO:0048477; GO:0036035; GO:0018105; GO:0038083; GO:0018108; GO:0016310; GO:0030168; GO:0043065; GO:0045780; GO:0090263; GO:0045785; GO:0045737; GO:0001819; GO:0035306; GO:2000573; GO:0045893; GO:0010634; GO:0070374; GO:0010628; GO:0010907; GO:0035332; GO:0046628; GO:0033625; GO:1902533; GO:2000394; GO:2000256; GO:0043406; GO:1903997; GO:0045747; GO:2000386; GO:0050731; GO:0043552; GO:0014068; GO:0010641; GO:2000588; GO:0071803; GO:0031954; GO:0051897; GO:1900182; GO:0010954; GO:0071902; GO:0051222; GO:0046579; GO:0051057; GO:0014911; GO:1904707; GO:0001545; GO:0050847; GO:0046777; GO:0031648; GO:0006468; GO:0045124; GO:2001286; GO:0060491; GO:0022407; GO:2000641; GO:0010632; GO:0033146; GO:0098962; GO:0043393; GO:0043114; GO:0010447; GO:0051602; GO:0070542; GO:0042542; GO:0070555; GO:0009612; GO:0051385; GO:0031667; GO:0009615; GO:0009410; GO:0007172; GO:0007165; GO:0014856; GO:0007283; GO:0002223; GO:0043149; GO:0034446; GO:0031295; GO:0045056; GO:0007179; GO:0007169; GO:0060065; GO:0048010","PTHR24418:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11283|UniProtKB=P12931","P06959; P06664; P00012; P00034; P00005; P00049"]
["Src",null,"SRC","60","rb",null,2,6,1,6,2,2,"# 1854",".ANG., .APH., .APO., .BLC., .CADH., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .DRR., .EGFR., .ErbB., .GPCR., .GPROT., .HEPB., .HIF., .HIPPO., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PARK., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .VEGFS., .VIR., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; Integrin signalling pathway; Angiogenesis; Parkinson disease","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","activation of protein kinase B activity; adherens junction organization; angiotensin-activated signaling pathway involved in heart process; bone resorption; brain development; branching involved in mammary gland duct morphogenesis; cell adhesion; cell cycle; cell differentiation; cell migration; cell population proliferation; cell-cell adhesion; cellular response to angiotensin; cellular response to fatty acid; cellular response to fluid shear stress; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to lipopolysaccharide; cellular response to peptide hormone stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to progesterone stimulus; cellular response to prolactin; cellular response to reactive oxygen species; cellular response to transforming growth factor beta stimulus; DNA biosynthetic process; entry of bacterium into host cell; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; focal adhesion assembly; forebrain development; immune system process; innate immune response; integrin-mediated signaling pathway; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; intracellular signal transduction; learning or memory; leukocyte migration; macroautophagy; myoblast proliferation; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of focal adhesion assembly; negative regulation of inflammatory response to antigenic stimulus; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of mitochondrial depolarization; negative regulation of protein-containing complex assembly; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; neurotrophin TRK receptor signaling pathway; odontogenesis; oogenesis; osteoclast development; peptidyl-serine phosphorylation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet activation; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt signaling pathway; positive regulation of cell adhesion; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of cytokine production; positive regulation of dephosphorylation; positive regulation of DNA biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose metabolic process; positive regulation of hippo signaling; positive regulation of insulin receptor signaling pathway; positive regulation of integrin activation; positive regulation of intracellular signal transduction; positive regulation of lamellipodium morphogenesis; positive regulation of male germ cell proliferation; positive regulation of MAP kinase activity; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of Notch signaling pathway; positive regulation of ovarian follicle development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of platelet-derived growth factor receptor-beta signaling pathway; positive regulation of podosome assembly; positive regulation of protein autophosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of protein processing; positive regulation of protein serine/threonine kinase activity; positive regulation of protein transport; positive regulation of Ras protein signal transduction; positive regulation of small GTPase mediated signal transduction; positive regulation of smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; primary ovarian follicle growth; progesterone receptor signaling pathway; protein autophosphorylation; protein destabilization; protein phosphorylation; regulation of bone resorption; regulation of caveolin-mediated endocytosis; regulation of cell projection assembly; regulation of cell-cell adhesion; regulation of early endosome to late endosome transport; regulation of epithelial cell migration; regulation of intracellular estrogen receptor signaling pathway; regulation of postsynaptic neurotransmitter receptor activity; regulation of protein binding; regulation of vascular permeability; response to acidic pH; response to electrical stimulus; response to fatty acid; response to hydrogen peroxide; response to interleukin-1; response to mechanical stimulus; response to mineralocorticoid; response to nutrient levels; response to virus; response to xenobiotic stimulus; signal complex assembly; signal transduction; skeletal muscle cell proliferation; spermatogenesis; stimulatory C-type lectin receptor signaling pathway; stress fiber assembly; substrate adhesion-dependent cell spreading; T cell costimulation; transcytosis; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; uterus development; vascular endothelial growth factor receptor signaling pathway","ATP binding; ATPase binding; BMP receptor binding; cadherin binding; cell adhesion molecule binding; connexin binding; enzyme binding; ephrin receptor binding; growth factor receptor binding; heme binding; insulin receptor binding; integrin binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nuclear estrogen receptor binding; nucleotide binding; phospholipase activator activity; phospholipase binding; phosphoprotein binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein kinase C binding; protein tyrosine kinase activity; protein-containing complex binding; scaffold protein binding; SH2 domain binding; signaling receptor binding; transferase activity; transmembrane transporter binding","actin filament; anchoring junction; caveola; cell junction; cytoplasm; cytoskeleton; cytosol; dendritic filopodium; dendritic growth cone; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; glutamatergic synapse; late endosome; lysosome; membrane; membrane raft; mitochondrial inner membrane; mitochondrion; neuron projection; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome; postsynaptic density; postsynaptic specialization, intracellular component; ruffle membrane; synaptic membrane","Tyrosine kinase / adaptor","SRC proto-oncogene, non-receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=6714","6714","20779","83805",null,null,null,"P12931","P05480","Q9WUD9","A0A8I3Q3C2","A0A5G2QDX5","F7FWN4","GO:0005884; GO:0070161; GO:0005901; GO:0030054; GO:0005737; GO:0005856; GO:0005829; GO:1902737; GO:0044294; GO:0070062; GO:0031234; GO:0005925; GO:0098978; GO:0005770; GO:0005764; GO:0016020; GO:0045121; GO:0005743; GO:0005739; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0002102; GO:0014069; GO:0099091; GO:0032587; GO:0097060","GO:0005524; GO:0051117; GO:0070700; GO:0045296; GO:0050839; GO:0071253; GO:0019899; GO:0046875; GO:0070851; GO:0020037; GO:0005158; GO:0005178; GO:0016301; GO:0004715; GO:0030331; GO:0000166; GO:0016004; GO:0043274; GO:0051219; GO:0005515; GO:0008022; GO:0019904; GO:0004672; GO:0019901; GO:0005080; GO:0004713; GO:0044877; GO:0097110; GO:0042169; GO:0005102; GO:0016740; GO:0044325","GO:0032148; GO:0034332; GO:0086098; GO:0045453; GO:0007420; GO:0060444; GO:0007155; GO:0007049; GO:0030154; GO:0016477; GO:0008283; GO:0098609; GO:1904385; GO:0071398; GO:0071498; GO:0070301; GO:0071456; GO:0032869; GO:0071222; GO:0071375; GO:0036120; GO:0071393; GO:1990646; GO:0034614; GO:0071560; GO:0071897; GO:0035635; GO:0048013; GO:0007173; GO:0038128; GO:0038096; GO:0048041; GO:0030900; GO:0002376; GO:0045087; GO:0007229; GO:0070102; GO:0060576; GO:0035556; GO:0007611; GO:0050900; GO:0016236; GO:0051450; GO:2000811; GO:0043066; GO:0043154; GO:0045892; GO:2001237; GO:0051895; GO:0002862; GO:2001243; GO:0051902; GO:0031333; GO:0051974; GO:0032211; GO:0048011; GO:0042476; GO:0048477; GO:0036035; GO:0018105; GO:0038083; GO:0018108; GO:0016310; GO:0030168; GO:0043065; GO:0045780; GO:0090263; GO:0045785; GO:0045737; GO:0001819; GO:0035306; GO:2000573; GO:0045893; GO:0010634; GO:0070374; GO:0010628; GO:0010907; GO:0035332; GO:0046628; GO:0033625; GO:1902533; GO:2000394; GO:2000256; GO:0043406; GO:1903997; GO:0045747; GO:2000386; GO:0050731; GO:0043552; GO:0014068; GO:0010641; GO:2000588; GO:0071803; GO:0031954; GO:0051897; GO:1900182; GO:0010954; GO:0071902; GO:0051222; GO:0046579; GO:0051057; GO:0014911; GO:1904707; GO:0001545; GO:0050847; GO:0046777; GO:0031648; GO:0006468; GO:0045124; GO:2001286; GO:0060491; GO:0022407; GO:2000641; GO:0010632; GO:0033146; GO:0098962; GO:0043393; GO:0043114; GO:0010447; GO:0051602; GO:0070542; GO:0042542; GO:0070555; GO:0009612; GO:0051385; GO:0031667; GO:0009615; GO:0009410; GO:0007172; GO:0007165; GO:0014856; GO:0007283; GO:0002223; GO:0043149; GO:0034446; GO:0031295; GO:0045056; GO:0007179; GO:0007169; GO:0060065; GO:0048010","PTHR24418:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11283|UniProtKB=P12931","P06959; P06664; P00012; P00034; P00005; P00049"]
["Src - phospho","Ser17","SRC","60","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2796",".ANG., .APH., .APO., .BLC., .CADH., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .ErbB., .GPCR., .GPROT., .HEPB., .HIF., .HIPPO., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PARK., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .VEGFS., .VIR., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; Integrin signalling pathway; Angiogenesis; Parkinson disease","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","activation of protein kinase B activity; adherens junction organization; angiotensin-activated signaling pathway involved in heart process; bone resorption; brain development; branching involved in mammary gland duct morphogenesis; cell adhesion; cell cycle; cell differentiation; cell migration; cell population proliferation; cell-cell adhesion; cellular response to angiotensin; cellular response to fatty acid; cellular response to fluid shear stress; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to lipopolysaccharide; cellular response to peptide hormone stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to progesterone stimulus; cellular response to prolactin; cellular response to reactive oxygen species; cellular response to transforming growth factor beta stimulus; DNA biosynthetic process; entry of bacterium into host cell; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; focal adhesion assembly; forebrain development; immune system process; innate immune response; integrin-mediated signaling pathway; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; intracellular signal transduction; learning or memory; leukocyte migration; macroautophagy; myoblast proliferation; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of focal adhesion assembly; negative regulation of inflammatory response to antigenic stimulus; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of mitochondrial depolarization; negative regulation of protein-containing complex assembly; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; neurotrophin TRK receptor signaling pathway; odontogenesis; oogenesis; osteoclast development; peptidyl-serine phosphorylation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet activation; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt signaling pathway; positive regulation of cell adhesion; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of cytokine production; positive regulation of dephosphorylation; positive regulation of DNA biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose metabolic process; positive regulation of hippo signaling; positive regulation of insulin receptor signaling pathway; positive regulation of integrin activation; positive regulation of intracellular signal transduction; positive regulation of lamellipodium morphogenesis; positive regulation of male germ cell proliferation; positive regulation of MAP kinase activity; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of Notch signaling pathway; positive regulation of ovarian follicle development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of platelet-derived growth factor receptor-beta signaling pathway; positive regulation of podosome assembly; positive regulation of protein autophosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of protein processing; positive regulation of protein serine/threonine kinase activity; positive regulation of protein transport; positive regulation of Ras protein signal transduction; positive regulation of small GTPase mediated signal transduction; positive regulation of smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; primary ovarian follicle growth; progesterone receptor signaling pathway; protein autophosphorylation; protein destabilization; protein phosphorylation; regulation of bone resorption; regulation of caveolin-mediated endocytosis; regulation of cell projection assembly; regulation of cell-cell adhesion; regulation of early endosome to late endosome transport; regulation of epithelial cell migration; regulation of intracellular estrogen receptor signaling pathway; regulation of postsynaptic neurotransmitter receptor activity; regulation of protein binding; regulation of vascular permeability; response to acidic pH; response to electrical stimulus; response to fatty acid; response to hydrogen peroxide; response to interleukin-1; response to mechanical stimulus; response to mineralocorticoid; response to nutrient levels; response to virus; response to xenobiotic stimulus; signal complex assembly; signal transduction; skeletal muscle cell proliferation; spermatogenesis; stimulatory C-type lectin receptor signaling pathway; stress fiber assembly; substrate adhesion-dependent cell spreading; T cell costimulation; transcytosis; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; uterus development; vascular endothelial growth factor receptor signaling pathway","ATP binding; ATPase binding; BMP receptor binding; cadherin binding; cell adhesion molecule binding; connexin binding; enzyme binding; ephrin receptor binding; growth factor receptor binding; heme binding; insulin receptor binding; integrin binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nuclear estrogen receptor binding; nucleotide binding; phospholipase activator activity; phospholipase binding; phosphoprotein binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein kinase C binding; protein tyrosine kinase activity; protein-containing complex binding; scaffold protein binding; SH2 domain binding; signaling receptor binding; transferase activity; transmembrane transporter binding","actin filament; anchoring junction; caveola; cell junction; cytoplasm; cytoskeleton; cytosol; dendritic filopodium; dendritic growth cone; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; glutamatergic synapse; late endosome; lysosome; membrane; membrane raft; mitochondrial inner membrane; mitochondrion; neuron projection; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome; postsynaptic density; postsynaptic specialization, intracellular component; ruffle membrane; synaptic membrane",null,"SRC proto-oncogene, non-receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=6714","6714","20779","83805",null,null,null,"P12931","P05480","Q9WUD9","A0A8I3Q3C2","A0A5G2QDX5","F7FWN4","GO:0005884; GO:0070161; GO:0005901; GO:0030054; GO:0005737; GO:0005856; GO:0005829; GO:1902737; GO:0044294; GO:0070062; GO:0031234; GO:0005925; GO:0098978; GO:0005770; GO:0005764; GO:0016020; GO:0045121; GO:0005743; GO:0005739; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0002102; GO:0014069; GO:0099091; GO:0032587; GO:0097060","GO:0005524; GO:0051117; GO:0070700; GO:0045296; GO:0050839; GO:0071253; GO:0019899; GO:0046875; GO:0070851; GO:0020037; GO:0005158; GO:0005178; GO:0016301; GO:0004715; GO:0030331; GO:0000166; GO:0016004; GO:0043274; GO:0051219; GO:0005515; GO:0008022; GO:0019904; GO:0004672; GO:0019901; GO:0005080; GO:0004713; GO:0044877; GO:0097110; GO:0042169; GO:0005102; GO:0016740; GO:0044325","GO:0032148; GO:0034332; GO:0086098; GO:0045453; GO:0007420; GO:0060444; GO:0007155; GO:0007049; GO:0030154; GO:0016477; GO:0008283; GO:0098609; GO:1904385; GO:0071398; GO:0071498; GO:0070301; GO:0071456; GO:0032869; GO:0071222; GO:0071375; GO:0036120; GO:0071393; GO:1990646; GO:0034614; GO:0071560; GO:0071897; GO:0035635; GO:0048013; GO:0007173; GO:0038128; GO:0038096; GO:0048041; GO:0030900; GO:0002376; GO:0045087; GO:0007229; GO:0070102; GO:0060576; GO:0035556; GO:0007611; GO:0050900; GO:0016236; GO:0051450; GO:2000811; GO:0043066; GO:0043154; GO:0045892; GO:2001237; GO:0051895; GO:0002862; GO:2001243; GO:0051902; GO:0031333; GO:0051974; GO:0032211; GO:0048011; GO:0042476; GO:0048477; GO:0036035; GO:0018105; GO:0038083; GO:0018108; GO:0016310; GO:0030168; GO:0043065; GO:0045780; GO:0090263; GO:0045785; GO:0045737; GO:0001819; GO:0035306; GO:2000573; GO:0045893; GO:0010634; GO:0070374; GO:0010628; GO:0010907; GO:0035332; GO:0046628; GO:0033625; GO:1902533; GO:2000394; GO:2000256; GO:0043406; GO:1903997; GO:0045747; GO:2000386; GO:0050731; GO:0043552; GO:0014068; GO:0010641; GO:2000588; GO:0071803; GO:0031954; GO:0051897; GO:1900182; GO:0010954; GO:0071902; GO:0051222; GO:0046579; GO:0051057; GO:0014911; GO:1904707; GO:0001545; GO:0050847; GO:0046777; GO:0031648; GO:0006468; GO:0045124; GO:2001286; GO:0060491; GO:0022407; GO:2000641; GO:0010632; GO:0033146; GO:0098962; GO:0043393; GO:0043114; GO:0010447; GO:0051602; GO:0070542; GO:0042542; GO:0070555; GO:0009612; GO:0051385; GO:0031667; GO:0009615; GO:0009410; GO:0007172; GO:0007165; GO:0014856; GO:0007283; GO:0002223; GO:0043149; GO:0034446; GO:0031295; GO:0045056; GO:0007179; GO:0007169; GO:0060065; GO:0048010","PTHR24418:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11283|UniProtKB=P12931","P06959; P06664; P00012; P00034; P00005; P00049"]
["Src - phospho","Tyr527","SRC","60","rb",null,2,1,1,6,2,2,"# 3127",".ANG., .APH., .APO., .BLC., .CADH., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .ErbB., .GPCR., .GPROT., .HEPB., .HIF., .HIPPO., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PARK., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .VEGFS., .VIR., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; Integrin signalling pathway; Angiogenesis; Parkinson disease","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","activation of protein kinase B activity; adherens junction organization; angiotensin-activated signaling pathway involved in heart process; bone resorption; brain development; branching involved in mammary gland duct morphogenesis; cell adhesion; cell cycle; cell differentiation; cell migration; cell population proliferation; cell-cell adhesion; cellular response to angiotensin; cellular response to fatty acid; cellular response to fluid shear stress; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to lipopolysaccharide; cellular response to peptide hormone stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to progesterone stimulus; cellular response to prolactin; cellular response to reactive oxygen species; cellular response to transforming growth factor beta stimulus; DNA biosynthetic process; entry of bacterium into host cell; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; focal adhesion assembly; forebrain development; immune system process; innate immune response; integrin-mediated signaling pathway; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; intracellular signal transduction; learning or memory; leukocyte migration; macroautophagy; myoblast proliferation; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of focal adhesion assembly; negative regulation of inflammatory response to antigenic stimulus; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of mitochondrial depolarization; negative regulation of protein-containing complex assembly; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; neurotrophin TRK receptor signaling pathway; odontogenesis; oogenesis; osteoclast development; peptidyl-serine phosphorylation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet activation; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt signaling pathway; positive regulation of cell adhesion; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of cytokine production; positive regulation of dephosphorylation; positive regulation of DNA biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose metabolic process; positive regulation of hippo signaling; positive regulation of insulin receptor signaling pathway; positive regulation of integrin activation; positive regulation of intracellular signal transduction; positive regulation of lamellipodium morphogenesis; positive regulation of male germ cell proliferation; positive regulation of MAP kinase activity; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of Notch signaling pathway; positive regulation of ovarian follicle development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of platelet-derived growth factor receptor-beta signaling pathway; positive regulation of podosome assembly; positive regulation of protein autophosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of protein processing; positive regulation of protein serine/threonine kinase activity; positive regulation of protein transport; positive regulation of Ras protein signal transduction; positive regulation of small GTPase mediated signal transduction; positive regulation of smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; primary ovarian follicle growth; progesterone receptor signaling pathway; protein autophosphorylation; protein destabilization; protein phosphorylation; regulation of bone resorption; regulation of caveolin-mediated endocytosis; regulation of cell projection assembly; regulation of cell-cell adhesion; regulation of early endosome to late endosome transport; regulation of epithelial cell migration; regulation of intracellular estrogen receptor signaling pathway; regulation of postsynaptic neurotransmitter receptor activity; regulation of protein binding; regulation of vascular permeability; response to acidic pH; response to electrical stimulus; response to fatty acid; response to hydrogen peroxide; response to interleukin-1; response to mechanical stimulus; response to mineralocorticoid; response to nutrient levels; response to virus; response to xenobiotic stimulus; signal complex assembly; signal transduction; skeletal muscle cell proliferation; spermatogenesis; stimulatory C-type lectin receptor signaling pathway; stress fiber assembly; substrate adhesion-dependent cell spreading; T cell costimulation; transcytosis; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; uterus development; vascular endothelial growth factor receptor signaling pathway","ATP binding; ATPase binding; BMP receptor binding; cadherin binding; cell adhesion molecule binding; connexin binding; enzyme binding; ephrin receptor binding; growth factor receptor binding; heme binding; insulin receptor binding; integrin binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nuclear estrogen receptor binding; nucleotide binding; phospholipase activator activity; phospholipase binding; phosphoprotein binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein kinase C binding; protein tyrosine kinase activity; protein-containing complex binding; scaffold protein binding; SH2 domain binding; signaling receptor binding; transferase activity; transmembrane transporter binding","actin filament; anchoring junction; caveola; cell junction; cytoplasm; cytoskeleton; cytosol; dendritic filopodium; dendritic growth cone; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; glutamatergic synapse; late endosome; lysosome; membrane; membrane raft; mitochondrial inner membrane; mitochondrion; neuron projection; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome; postsynaptic density; postsynaptic specialization, intracellular component; ruffle membrane; synaptic membrane","Tyrosine kinase / adaptor","SRC proto-oncogene, non-receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=6714","6714","20779","83805",null,null,null,"P12931","P05480","Q9WUD9","A0A8I3Q3C2","A0A5G2QDX5","F7FWN4","GO:0005884; GO:0070161; GO:0005901; GO:0030054; GO:0005737; GO:0005856; GO:0005829; GO:1902737; GO:0044294; GO:0070062; GO:0031234; GO:0005925; GO:0098978; GO:0005770; GO:0005764; GO:0016020; GO:0045121; GO:0005743; GO:0005739; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0002102; GO:0014069; GO:0099091; GO:0032587; GO:0097060","GO:0005524; GO:0051117; GO:0070700; GO:0045296; GO:0050839; GO:0071253; GO:0019899; GO:0046875; GO:0070851; GO:0020037; GO:0005158; GO:0005178; GO:0016301; GO:0004715; GO:0030331; GO:0000166; GO:0016004; GO:0043274; GO:0051219; GO:0005515; GO:0008022; GO:0019904; GO:0004672; GO:0019901; GO:0005080; GO:0004713; GO:0044877; GO:0097110; GO:0042169; GO:0005102; GO:0016740; GO:0044325","GO:0032148; GO:0034332; GO:0086098; GO:0045453; GO:0007420; GO:0060444; GO:0007155; GO:0007049; GO:0030154; GO:0016477; GO:0008283; GO:0098609; GO:1904385; GO:0071398; GO:0071498; GO:0070301; GO:0071456; GO:0032869; GO:0071222; GO:0071375; GO:0036120; GO:0071393; GO:1990646; GO:0034614; GO:0071560; GO:0071897; GO:0035635; GO:0048013; GO:0007173; GO:0038128; GO:0038096; GO:0048041; GO:0030900; GO:0002376; GO:0045087; GO:0007229; GO:0070102; GO:0060576; GO:0035556; GO:0007611; GO:0050900; GO:0016236; GO:0051450; GO:2000811; GO:0043066; GO:0043154; GO:0045892; GO:2001237; GO:0051895; GO:0002862; GO:2001243; GO:0051902; GO:0031333; GO:0051974; GO:0032211; GO:0048011; GO:0042476; GO:0048477; GO:0036035; GO:0018105; GO:0038083; GO:0018108; GO:0016310; GO:0030168; GO:0043065; GO:0045780; GO:0090263; GO:0045785; GO:0045737; GO:0001819; GO:0035306; GO:2000573; GO:0045893; GO:0010634; GO:0070374; GO:0010628; GO:0010907; GO:0035332; GO:0046628; GO:0033625; GO:1902533; GO:2000394; GO:2000256; GO:0043406; GO:1903997; GO:0045747; GO:2000386; GO:0050731; GO:0043552; GO:0014068; GO:0010641; GO:2000588; GO:0071803; GO:0031954; GO:0051897; GO:1900182; GO:0010954; GO:0071902; GO:0051222; GO:0046579; GO:0051057; GO:0014911; GO:1904707; GO:0001545; GO:0050847; GO:0046777; GO:0031648; GO:0006468; GO:0045124; GO:2001286; GO:0060491; GO:0022407; GO:2000641; GO:0010632; GO:0033146; GO:0098962; GO:0043393; GO:0043114; GO:0010447; GO:0051602; GO:0070542; GO:0042542; GO:0070555; GO:0009612; GO:0051385; GO:0031667; GO:0009615; GO:0009410; GO:0007172; GO:0007165; GO:0014856; GO:0007283; GO:0002223; GO:0043149; GO:0034446; GO:0031295; GO:0045056; GO:0007179; GO:0007169; GO:0060065; GO:0048010","PTHR24418:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11283|UniProtKB=P12931","P06959; P06664; P00012; P00034; P00005; P00049"]
["Src family - phospho","Tyr416","SRC","60","rb",null,2,1,1,8,1.1000000000000001,8,"# 2822",".ANG., .APH., .APO., .BLC., .CADH., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .ErbB., .GPCR., .GPROT., .HEPB., .HIF., .HIPPO., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PARK., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .VEGFS., .VIR., .WNT.","CCKR signaling map; Gonadotropin releasing hormone receptor pathway; Cadherin signaling pathway; Integrin signalling pathway; Angiogenesis; Parkinson disease","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","activation of protein kinase B activity; adherens junction organization; angiotensin-activated signaling pathway involved in heart process; bone resorption; brain development; branching involved in mammary gland duct morphogenesis; cell adhesion; cell cycle; cell differentiation; cell migration; cell population proliferation; cell-cell adhesion; cellular response to angiotensin; cellular response to fatty acid; cellular response to fluid shear stress; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to lipopolysaccharide; cellular response to peptide hormone stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to progesterone stimulus; cellular response to prolactin; cellular response to reactive oxygen species; cellular response to transforming growth factor beta stimulus; DNA biosynthetic process; entry of bacterium into host cell; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; focal adhesion assembly; forebrain development; immune system process; innate immune response; integrin-mediated signaling pathway; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; intracellular signal transduction; learning or memory; leukocyte migration; macroautophagy; myoblast proliferation; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of focal adhesion assembly; negative regulation of inflammatory response to antigenic stimulus; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of mitochondrial depolarization; negative regulation of protein-containing complex assembly; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; neurotrophin TRK receptor signaling pathway; odontogenesis; oogenesis; osteoclast development; peptidyl-serine phosphorylation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet activation; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt signaling pathway; positive regulation of cell adhesion; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of cytokine production; positive regulation of dephosphorylation; positive regulation of DNA biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of epithelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose metabolic process; positive regulation of hippo signaling; positive regulation of insulin receptor signaling pathway; positive regulation of integrin activation; positive regulation of intracellular signal transduction; positive regulation of lamellipodium morphogenesis; positive regulation of male germ cell proliferation; positive regulation of MAP kinase activity; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of Notch signaling pathway; positive regulation of ovarian follicle development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of platelet-derived growth factor receptor-beta signaling pathway; positive regulation of podosome assembly; positive regulation of protein autophosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of protein processing; positive regulation of protein serine/threonine kinase activity; positive regulation of protein transport; positive regulation of Ras protein signal transduction; positive regulation of small GTPase mediated signal transduction; positive regulation of smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; primary ovarian follicle growth; progesterone receptor signaling pathway; protein autophosphorylation; protein destabilization; protein phosphorylation; regulation of bone resorption; regulation of caveolin-mediated endocytosis; regulation of cell projection assembly; regulation of cell-cell adhesion; regulation of early endosome to late endosome transport; regulation of epithelial cell migration; regulation of intracellular estrogen receptor signaling pathway; regulation of postsynaptic neurotransmitter receptor activity; regulation of protein binding; regulation of vascular permeability; response to acidic pH; response to electrical stimulus; response to fatty acid; response to hydrogen peroxide; response to interleukin-1; response to mechanical stimulus; response to mineralocorticoid; response to nutrient levels; response to virus; response to xenobiotic stimulus; signal complex assembly; signal transduction; skeletal muscle cell proliferation; spermatogenesis; stimulatory C-type lectin receptor signaling pathway; stress fiber assembly; substrate adhesion-dependent cell spreading; T cell costimulation; transcytosis; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; uterus development; vascular endothelial growth factor receptor signaling pathway","ATP binding; ATPase binding; BMP receptor binding; cadherin binding; cell adhesion molecule binding; connexin binding; enzyme binding; ephrin receptor binding; growth factor receptor binding; heme binding; insulin receptor binding; integrin binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nuclear estrogen receptor binding; nucleotide binding; phospholipase activator activity; phospholipase binding; phosphoprotein binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein kinase C binding; protein tyrosine kinase activity; protein-containing complex binding; scaffold protein binding; SH2 domain binding; signaling receptor binding; transferase activity; transmembrane transporter binding","actin filament; anchoring junction; caveola; cell junction; cytoplasm; cytoskeleton; cytosol; dendritic filopodium; dendritic growth cone; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; glutamatergic synapse; late endosome; lysosome; membrane; membrane raft; mitochondrial inner membrane; mitochondrion; neuron projection; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome; postsynaptic density; postsynaptic specialization, intracellular component; ruffle membrane; synaptic membrane","Tyrosine kinase / adaptor","SRC proto-oncogene, non-receptor tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=6714","6714","20779","83805",null,null,null,"P12931","P05480","Q9WUD9","A0A8I3Q3C2","A0A5G2QDX5","F7FWN4","GO:0005884; GO:0070161; GO:0005901; GO:0030054; GO:0005737; GO:0005856; GO:0005829; GO:1902737; GO:0044294; GO:0070062; GO:0031234; GO:0005925; GO:0098978; GO:0005770; GO:0005764; GO:0016020; GO:0045121; GO:0005743; GO:0005739; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0048471; GO:0005886; GO:0002102; GO:0014069; GO:0099091; GO:0032587; GO:0097060","GO:0005524; GO:0051117; GO:0070700; GO:0045296; GO:0050839; GO:0071253; GO:0019899; GO:0046875; GO:0070851; GO:0020037; GO:0005158; GO:0005178; GO:0016301; GO:0004715; GO:0030331; GO:0000166; GO:0016004; GO:0043274; GO:0051219; GO:0005515; GO:0008022; GO:0019904; GO:0004672; GO:0019901; GO:0005080; GO:0004713; GO:0044877; GO:0097110; GO:0042169; GO:0005102; GO:0016740; GO:0044325","GO:0032148; GO:0034332; GO:0086098; GO:0045453; GO:0007420; GO:0060444; GO:0007155; GO:0007049; GO:0030154; GO:0016477; GO:0008283; GO:0098609; GO:1904385; GO:0071398; GO:0071498; GO:0070301; GO:0071456; GO:0032869; GO:0071222; GO:0071375; GO:0036120; GO:0071393; GO:1990646; GO:0034614; GO:0071560; GO:0071897; GO:0035635; GO:0048013; GO:0007173; GO:0038128; GO:0038096; GO:0048041; GO:0030900; GO:0002376; GO:0045087; GO:0007229; GO:0070102; GO:0060576; GO:0035556; GO:0007611; GO:0050900; GO:0016236; GO:0051450; GO:2000811; GO:0043066; GO:0043154; GO:0045892; GO:2001237; GO:0051895; GO:0002862; GO:2001243; GO:0051902; GO:0031333; GO:0051974; GO:0032211; GO:0048011; GO:0042476; GO:0048477; GO:0036035; GO:0018105; GO:0038083; GO:0018108; GO:0016310; GO:0030168; GO:0043065; GO:0045780; GO:0090263; GO:0045785; GO:0045737; GO:0001819; GO:0035306; GO:2000573; GO:0045893; GO:0010634; GO:0070374; GO:0010628; GO:0010907; GO:0035332; GO:0046628; GO:0033625; GO:1902533; GO:2000394; GO:2000256; GO:0043406; GO:1903997; GO:0045747; GO:2000386; GO:0050731; GO:0043552; GO:0014068; GO:0010641; GO:2000588; GO:0071803; GO:0031954; GO:0051897; GO:1900182; GO:0010954; GO:0071902; GO:0051222; GO:0046579; GO:0051057; GO:0014911; GO:1904707; GO:0001545; GO:0050847; GO:0046777; GO:0031648; GO:0006468; GO:0045124; GO:2001286; GO:0060491; GO:0022407; GO:2000641; GO:0010632; GO:0033146; GO:0098962; GO:0043393; GO:0043114; GO:0010447; GO:0051602; GO:0070542; GO:0042542; GO:0070555; GO:0009612; GO:0051385; GO:0031667; GO:0009615; GO:0009410; GO:0007172; GO:0007165; GO:0014856; GO:0007283; GO:0002223; GO:0043149; GO:0034446; GO:0031295; GO:0045056; GO:0007179; GO:0007169; GO:0060065; GO:0048010","PTHR24418:SF53","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11283|UniProtKB=P12931","P06959; P06664; P00012; P00034; P00005; P00049"]
["SRC-1 (NCOA1)",null,"NCOA1","180","rb",null,6,4,8,8,8,8,"# 1103",".APO., .BRC., .CANCER., .CANPTHW., .CD., .CSP., .INS., .OP., .OPA., .OT., .SREME., .ST., .TRASR.",null,"NUCLEAR RECEPTOR COACTIVATOR 1","cellular response to hormone stimulus; cellular response to Thyroglobulin triiodothyronine; histone modification; labyrinthine layer morphogenesis; mRNA transcription by RNA polymerase II; peroxisome proliferator activated receptor signaling pathway; positive regulation of adipose tissue development; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter by galactose; regulation of cellular response to insulin stimulus; regulation of DNA-templated transcription; regulation of thyroid hormone mediated signaling pathway","acyltransferase activity; aryl hydrocarbon receptor binding; chromatin binding; DNA binding; enzyme binding; histone acetyltransferase activity; nuclear estrogen receptor binding; nuclear receptor binding; nuclear receptor coactivator activity; protein binding; protein dimerization activity; protein N-terminus binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity; transferase activity","chromatin; cytosol; nucleoplasm; nucleus; plasma membrane; protein-containing complex; RNA polymerase II transcription regulator complex; transcription regulator complex","Nuclear receptor","nuclear receptor coactivator 1","http://www.ncbi.nlm.nih.gov/gene/?term=8648","8648","17977","313929","475684",null,null,"Q15788","P70365","A0A0G2JZG4","A0A8P0N6V4","A0A287AFF0","A0A5F7ZMY0","GO:0000785; GO:0005829; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0090575; GO:0005667","GO:0016746; GO:0017162; GO:0003682; GO:0003677; GO:0019899; GO:0004402; GO:0030331; GO:0016922; GO:0030374; GO:0005515; GO:0046983; GO:0047485; GO:0061629; GO:0003713; GO:0016740","GO:0032870; GO:1904017; GO:0016570; GO:0060713; GO:0042789; GO:0035357; GO:1904179; GO:0043065; GO:0045893; GO:0045666; GO:0045944; GO:0000435; GO:1900076; GO:0006355; GO:0002155","PTHR10684:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7668|UniProtKB=Q15788"]
["SRC-3 (NCOA3)",null,"NCOA3","160","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1097",".BRC., .CANCER., .CANPTHW., .OP., .OT., .TRASR.","Gonadotropin releasing hormone receptor pathway","NUCLEAR RECEPTOR COACTIVATOR 3","cell dedifferentiation; cellular response to estradiol stimulus; cellular response to hormone stimulus; histone modification; positive regulation of keratinocyte differentiation; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; receptor transactivation; regulation of DNA-templated transcription; regulation of stem cell division","acyltransferase activity; disordered domain specific binding; histone acetyltransferase activity; molecular adaptor activity; nuclear receptor binding; nuclear receptor coactivator activity; nuclear thyroid hormone receptor binding; protein binding; protein dimerization activity; protein N-terminus binding; RNA polymerase II complex binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity; transferase activity","chromatin; cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus; protein-containing complex","Nuclear receptor","nuclear receptor coactivator 3","http://www.ncbi.nlm.nih.gov/gene/?term=8202","8202","17979","84584",null,null,null,"Q9Y6Q9","A2A468","F1M8E5","A0A8P0NCV6","A0A286ZML8","A0A5F8AJH5","GO:0000785; GO:0005737; GO:0005829; GO:0070062; GO:0005654; GO:0005634; GO:0032991","GO:0016746; GO:0097718; GO:0004402; GO:0060090; GO:0016922; GO:0030374; GO:0046966; GO:0005515; GO:0046983; GO:0047485; GO:0000993; GO:0061629; GO:0003713; GO:0016740","GO:0043697; GO:0071392; GO:0032870; GO:0016570; GO:0045618; GO:1902459; GO:0045944; GO:0035624; GO:0006355; GO:2000035","PTHR10684:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7670|UniProtKB=Q9Y6Q9","P06664"]
["SRC-3 (NCOA3)",null,"NCOA3","160","rb",null,7,2,7,7,8,8,"# 1098",".BRC., .CANCER., .CANPTHW., .OP., .OT., .TRASR.","Gonadotropin releasing hormone receptor pathway","NUCLEAR RECEPTOR COACTIVATOR 3","cell dedifferentiation; cellular response to estradiol stimulus; cellular response to hormone stimulus; histone modification; positive regulation of keratinocyte differentiation; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; receptor transactivation; regulation of DNA-templated transcription; regulation of stem cell division","acyltransferase activity; disordered domain specific binding; histone acetyltransferase activity; molecular adaptor activity; nuclear receptor binding; nuclear receptor coactivator activity; nuclear thyroid hormone receptor binding; protein binding; protein dimerization activity; protein N-terminus binding; RNA polymerase II complex binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity; transferase activity","chromatin; cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus; protein-containing complex","Nuclear receptor","nuclear receptor coactivator 3","http://www.ncbi.nlm.nih.gov/gene/?term=8202","8202","17979","84584",null,null,null,"Q9Y6Q9","A2A468","F1M8E5","A0A8P0NCV6","A0A286ZML8","A0A5F8AJH5","GO:0000785; GO:0005737; GO:0005829; GO:0070062; GO:0005654; GO:0005634; GO:0032991","GO:0016746; GO:0097718; GO:0004402; GO:0060090; GO:0016922; GO:0030374; GO:0046966; GO:0005515; GO:0046983; GO:0047485; GO:0000993; GO:0061629; GO:0003713; GO:0016740","GO:0043697; GO:0071392; GO:0032870; GO:0016570; GO:0045618; GO:1902459; GO:0045944; GO:0035624; GO:0006355; GO:2000035","PTHR10684:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7670|UniProtKB=Q9Y6Q9","P06664"]
["SRC-3 (NCOA3) - phospho","Thr24","NCOA3","160","rb",null,1,1,1,8,8,8,"# 1096",".BRC., .CANCER., .CANPTHW., .OP., .OT., .TRASR.","Gonadotropin releasing hormone receptor pathway","NUCLEAR RECEPTOR COACTIVATOR 3","cell dedifferentiation; cellular response to estradiol stimulus; cellular response to hormone stimulus; histone modification; positive regulation of keratinocyte differentiation; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; receptor transactivation; regulation of DNA-templated transcription; regulation of stem cell division","acyltransferase activity; disordered domain specific binding; histone acetyltransferase activity; molecular adaptor activity; nuclear receptor binding; nuclear receptor coactivator activity; nuclear thyroid hormone receptor binding; protein binding; protein dimerization activity; protein N-terminus binding; RNA polymerase II complex binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity; transferase activity","chromatin; cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus; protein-containing complex","Nuclear receptor","nuclear receptor coactivator 3","http://www.ncbi.nlm.nih.gov/gene/?term=8202","8202","17979","84584",null,null,null,"Q9Y6Q9","A2A468","F1M8E5","A0A8P0NCV6","A0A286ZML8","A0A5F8AJH5","GO:0000785; GO:0005737; GO:0005829; GO:0070062; GO:0005654; GO:0005634; GO:0032991","GO:0016746; GO:0097718; GO:0004402; GO:0060090; GO:0016922; GO:0030374; GO:0046966; GO:0005515; GO:0046983; GO:0047485; GO:0000993; GO:0061629; GO:0003713; GO:0016740","GO:0043697; GO:0071392; GO:0032870; GO:0016570; GO:0045618; GO:1902459; GO:0045944; GO:0035624; GO:0006355; GO:2000035","PTHR10684:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=7670|UniProtKB=Q9Y6Q9","P06664"]
["SRF",null,"SRF","67","rb",null,2,1.1000000000000001,8,8,8,8,"# 1119",".ANG., .CANCER., .CCKR., .CCP., .CP., .CSP., .HIF., .INT., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .PDGF., .PLAT., .RAS., .RTK., .SREME., .TD., .TMAT., .TRASR.","CCKR signaling map; p38 MAPK pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Ras Pathway; PDGF signaling pathway","SERUM RESPONSE FACTOR","actin cytoskeleton organization; actin filament organization; angiogenesis involved in wound healing; animal organ development; associative learning; axon extension; bicellular tight junction assembly; branching involved in blood vessel morphogenesis; bronchus cartilage development; cardiac muscle cell myoblast differentiation; cardiac myofibril assembly; cardiac vascular smooth muscle cell differentiation; cell migration involved in sprouting angiogenesis; cell-cell adhesion; cell-matrix adhesion; cellular response to glucose stimulus; cellular senescence; contractile actin filament bundle assembly; developmental growth; dorsal aorta morphogenesis; epithelial cell-cell adhesion; epithelial structure maintenance; erythrocyte development; eyelid development in camera-type eye; face development; filopodium assembly; forebrain development; gastrulation; heart development; heart looping; heart trabecula formation; hematopoietic stem cell differentiation; hippocampus development; in utero embryonic development; leukocyte differentiation; long-term memory; long-term synaptic depression; lung morphogenesis; lung smooth muscle development; megakaryocyte development; mesoderm formation; morphogenesis of an epithelial sheet; muscle cell cellular homeostasis; negative regulation of amyloid-beta clearance; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of miRNA transcription; neuron development; neuron migration; neuron projection development; obsolete regulation of water loss via skin; platelet activation; platelet formation; positive regulation of axon extension; positive regulation of cell differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of filopodium assembly; positive regulation of miRNA transcription; positive regulation of smooth muscle contraction; positive regulation of transcription by glucose; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; positive thymic T cell selection; primitive streak formation; regulation of cell adhesion; regulation of DNA-templated transcription; regulation of smooth muscle cell differentiation; regulation of transcription by RNA polymerase II; response to cytokine; response to hormone; response to hypoxia; response to toxic substance; sarcomere organization; skin morphogenesis; stress fiber assembly; tangential migration from the subventricular zone to the olfactory bulb; thymus development; thyroid gland development; trachea cartilage development; transcription by RNA polymerase II; trophectodermal cell differentiation","chromatin binding; chromatin DNA binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; histone deacetylase binding; primary miRNA binding; protein binding; protein dimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; serum response element binding","chromatin; cytoplasm; nucleoplasm; nucleus","Transcription factor","serum response factor","http://www.ncbi.nlm.nih.gov/gene/?term=6722","6722","20807","501099","612861","100155958","698861","P11831","Q9JM73","D3ZHH8","A0A8I3RW30","F1RRM9","H9YW01","GO:0000785; GO:0005737; GO:0005654; GO:0005634","GO:0003682; GO:0031490; GO:0000987; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0042826; GO:0070878; GO:0005515; GO:0046983; GO:0042803; GO:0000978; GO:0000977; GO:0061629; GO:0043565; GO:1990837; GO:0010736","GO:0030036; GO:0007015; GO:0060055; GO:0048513; GO:0008306; GO:0048675; GO:0070830; GO:0001569; GO:0060532; GO:0060379; GO:0055003; GO:0060947; GO:0002042; GO:0098609; GO:0007160; GO:0071333; GO:0090398; GO:0030038; GO:0048589; GO:0035912; GO:0090136; GO:0010669; GO:0048821; GO:0061029; GO:0060324; GO:0046847; GO:0030900; GO:0007369; GO:0007507; GO:0001947; GO:0060347; GO:0060218; GO:0021766; GO:0001701; GO:0002521; GO:0007616; GO:0060292; GO:0060425; GO:0061145; GO:0035855; GO:0001707; GO:0002011; GO:0046716; GO:1900222; GO:0030336; GO:0008285; GO:1902894; GO:0048666; GO:0001764; GO:0031175; GO:0033561; GO:0030168; GO:0030220; GO:0045773; GO:0045597; GO:0051091; GO:0045893; GO:0051491; GO:1902895; GO:0045987; GO:0046016; GO:0045944; GO:0060261; GO:0045059; GO:0090009; GO:0030155; GO:0006355; GO:0051150; GO:0006357; GO:0034097; GO:0009725; GO:0001666; GO:0009636; GO:0045214; GO:0043589; GO:0043149; GO:0022028; GO:0048538; GO:0030878; GO:0060534; GO:0006366; GO:0001829","PTHR48019:SF168","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11291|UniProtKB=P11831","P06959; P05918; P00036; P06664; P04393; P00047"]
["SSEA3",null,"B3GALT5","36","rt",null,4,4,"n/a","n/a","n/a","n/a","# 0932",null,null,"BETA-1,3-GALACTOSYLTRANSFERASE 5","lipid metabolic process; oligosaccharide biosynthetic process; protein glycosylation; response to bacterium","glycosyltransferase activity; hexosyltransferase activity; protein binding; transferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; UDP-glycosyltransferase activity","endoplasmic reticulum; Golgi apparatus; Golgi membrane; membrane","Stem cell marker","beta-1,3-galactosyltransferase 5","http://www.ncbi.nlm.nih.gov/gene/?term=10317","10317","93961","288161",null,null,null,"Q9Y2C3","Q9JI67","D4AB20",null,null,"F7F9E6","GO:0005783; GO:0005794; GO:0000139; GO:0016020","GO:0016757; GO:0016758; GO:0005515; GO:0016740; GO:0008499; GO:0008194","GO:0006629; GO:0009312; GO:0006486; GO:0009617","PTHR11214:SF265","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=920|UniProtKB=Q9Y2C3"]
["SSEA4",null,null,"n.a.","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0701",null,null,null,null,null,null,"Stem cell marker",null,null,null,null,null,null,null,null,"n.a."]
["STAT 1",null,"STAT1","91, 84","rb",null,1,4,8,1,1,8,"# 2801",".ANG., .APO., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DI., .DRR., .EGFR., .GPCR., .HEPB., .IIR., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .NFKB., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","Interleukin signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Angiogenesis; Oxidative stress response; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; p53 pathway feedback loops 2","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA","blood circulation; cellular response to cytokine stimulus; cellular response to insulin stimulus; cellular response to interferon-beta; cellular response to organic cyclic compound; cellular response to type II interferon; cytokine-mediated signaling pathway; defense response; defense response to virus; endothelial cell migration; interleukin-27-mediated signaling pathway; macrophage derived foam cell differentiation; metanephric mesenchymal cell differentiation; metanephric mesenchymal cell proliferation involved in metanephros development; negative regulation by virus of viral protein levels in host cell; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of metanephric nephron tubule epithelial cell differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of defense response to virus by host; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of interferon-alpha production; positive regulation of mesenchymal cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of apoptotic process; regulation of cell population proliferation; regulation of DNA-templated transcription; renal tubule development; response to cAMP; response to cytokine; response to hydrogen peroxide; response to interferon-beta; response to mechanical stimulus; response to nutrient; response to organic cyclic compound; response to peptide hormone; response to type II interferon; response to xenobiotic stimulus; signal transduction; tumor necrosis factor-mediated signaling pathway; type I interferon-mediated signaling pathway; type II interferon-mediated signaling pathway","cadherin binding; CCR5 chemokine receptor binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; histone binding; identical protein binding; nuclear receptor binding; promoter-specific chromatin binding; protein binding; protein homodimerization activity; protein phosphatase 2A binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator binding; transcription corepressor binding; tumor necrosis factor receptor binding; ubiquitin-like protein ligase binding","axon; chromatin; cytoplasm; cytosol; dendrite; ISGF3 complex; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 1","http://www.ncbi.nlm.nih.gov/gene/?term=6772","6772",null,null,null,null,"693650","P42224","A0A087WRI1","A0A0G2JX93","A0A8I3PR74","A0A286ZN85","A0A1D5R5F0","GO:0030424; GO:0000785; GO:0005737; GO:0005829; GO:0030425; GO:0070721; GO:0005730; GO:0005654; GO:0005634; GO:0048471; GO:0032991; GO:0090575","GO:0045296; GO:0031730; GO:0003677; GO:0003700; GO:0000981; GO:0003690; GO:0019899; GO:0035035; GO:0042393; GO:0042802; GO:0016922; GO:1990841; GO:0005515; GO:0042803; GO:0051721; GO:0000978; GO:0000979; GO:0000977; GO:0043565; GO:0001223; GO:0001222; GO:0005164; GO:0044389","GO:0008015; GO:0071345; GO:0032869; GO:0035458; GO:0071407; GO:0071346; GO:0019221; GO:0006952; GO:0051607; GO:0043542; GO:0070106; GO:0010742; GO:0072162; GO:0072136; GO:0046725; GO:0016525; GO:0001937; GO:0043124; GO:0003340; GO:0072308; GO:0000122; GO:0008284; GO:0002230; GO:0045893; GO:0045648; GO:0032727; GO:0002053; GO:0051770; GO:0048661; GO:0045944; GO:0007259; GO:0042981; GO:0042127; GO:0006355; GO:0061326; GO:0051591; GO:0034097; GO:0042542; GO:0035456; GO:0009612; GO:0007584; GO:0014070; GO:0043434; GO:0034341; GO:0009410; GO:0007165; GO:0033209; GO:0060337; GO:0060333","PTHR11801:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11362|UniProtKB=P42224","P00036; P04393; P00035; P00047; P00038; P00005; P00046; P00018; P00031; P04398"]
["STAT 1 - phospho","Tyr701","STAT1","91, 84","rb",null,1,4,8,8,8,8,"# 3091",".ANG., .APO., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .DI., .DRR., .EGFR., .GPCR., .HEPB., .IIR., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .NFKB., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","Interleukin signaling pathway; Ras Pathway; Interferon-gamma signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Angiogenesis; Oxidative stress response; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; p53 pathway feedback loops 2","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA","blood circulation; cellular response to cytokine stimulus; cellular response to insulin stimulus; cellular response to interferon-beta; cellular response to organic cyclic compound; cellular response to type II interferon; cytokine-mediated signaling pathway; defense response; defense response to virus; endothelial cell migration; interleukin-27-mediated signaling pathway; macrophage derived foam cell differentiation; metanephric mesenchymal cell differentiation; metanephric mesenchymal cell proliferation involved in metanephros development; negative regulation by virus of viral protein levels in host cell; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of metanephric nephron tubule epithelial cell differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of defense response to virus by host; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of interferon-alpha production; positive regulation of mesenchymal cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of apoptotic process; regulation of cell population proliferation; regulation of DNA-templated transcription; renal tubule development; response to cAMP; response to cytokine; response to hydrogen peroxide; response to interferon-beta; response to mechanical stimulus; response to nutrient; response to organic cyclic compound; response to peptide hormone; response to type II interferon; response to xenobiotic stimulus; signal transduction; tumor necrosis factor-mediated signaling pathway; type I interferon-mediated signaling pathway; type II interferon-mediated signaling pathway","cadherin binding; CCR5 chemokine receptor binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; histone binding; identical protein binding; nuclear receptor binding; promoter-specific chromatin binding; protein binding; protein homodimerization activity; protein phosphatase 2A binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator binding; transcription corepressor binding; tumor necrosis factor receptor binding; ubiquitin-like protein ligase binding","axon; chromatin; cytoplasm; cytosol; dendrite; ISGF3 complex; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 1","http://www.ncbi.nlm.nih.gov/gene/?term=6772","6772",null,null,null,null,"693650","P42224","A0A087WRI1","A0A0G2JX93","A0A8I3PR74","A0A286ZN85","A0A1D5R5F0","GO:0030424; GO:0000785; GO:0005737; GO:0005829; GO:0030425; GO:0070721; GO:0005730; GO:0005654; GO:0005634; GO:0048471; GO:0032991; GO:0090575","GO:0045296; GO:0031730; GO:0003677; GO:0003700; GO:0000981; GO:0003690; GO:0019899; GO:0035035; GO:0042393; GO:0042802; GO:0016922; GO:1990841; GO:0005515; GO:0042803; GO:0051721; GO:0000978; GO:0000979; GO:0000977; GO:0043565; GO:0001223; GO:0001222; GO:0005164; GO:0044389","GO:0008015; GO:0071345; GO:0032869; GO:0035458; GO:0071407; GO:0071346; GO:0019221; GO:0006952; GO:0051607; GO:0043542; GO:0070106; GO:0010742; GO:0072162; GO:0072136; GO:0046725; GO:0016525; GO:0001937; GO:0043124; GO:0003340; GO:0072308; GO:0000122; GO:0008284; GO:0002230; GO:0045893; GO:0045648; GO:0032727; GO:0002053; GO:0051770; GO:0048661; GO:0045944; GO:0007259; GO:0042981; GO:0042127; GO:0006355; GO:0061326; GO:0051591; GO:0034097; GO:0042542; GO:0035456; GO:0009612; GO:0007584; GO:0014070; GO:0043434; GO:0034341; GO:0009410; GO:0007165; GO:0033209; GO:0060337; GO:0060333","PTHR11801:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11362|UniProtKB=P42224","P00036; P04393; P00035; P00047; P00038; P00005; P00046; P00018; P00031; P04398"]
["STAT 2",null,"STAT2","130","rb",null,4,2,4,4,8,1,"# 0220",".CANCER., .CANPTHW., .CCP., .CP., .CSP., .DI., .EGFR., .HEPB., .IMUF., .IMUR., .INFG., .INFM., .INT., .OP., .OPA., .OT., .PDGF., .RTK., .ST., .STAT., .TRASR., .VIR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2","cytokine-mediated signaling pathway; defense response; defense response to virus; negative regulation of type I interferon-mediated signaling pathway; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of mitochondrial fission; regulation of protein phosphorylation; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction; type I interferon-mediated signaling pathway","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; ubiquitin-like protein ligase binding","chromatin; cytoplasm; cytosol; ISGF3 complex; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 2","http://www.ncbi.nlm.nih.gov/gene/?term=6773","6773",null,null,null,"396923",null,"P52630","E9QJX9","A0A0G2K9T9","A0A8P0N3D7","O02799","A0A1D5RB61","GO:0000785; GO:0005737; GO:0005829; GO:0070721; GO:0005654; GO:0005634; GO:0005886; GO:0090575","GO:0003677; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0000978; GO:0044389","GO:0019221; GO:0006952; GO:0051607; GO:0060339; GO:0045944; GO:0007259; GO:0042127; GO:0006355; GO:0090140; GO:0001932; GO:0006357; GO:0043434; GO:0007165; GO:0060337","PTHR11801:SF41","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11363|UniProtKB=P52630","P00036; P00047; P00038; P00018"]
["STAT 2",null,"STAT2","113","rb",null,6,2.1,7,7,7,7,"# 0649",".CANCER., .CANPTHW., .CCP., .CP., .CSP., .DI., .EGFR., .HEPB., .IMUF., .IMUR., .INFG., .INFM., .INT., .OP., .OPA., .OT., .PDGF., .RTK., .ST., .STAT., .TRASR., .VIR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2","cytokine-mediated signaling pathway; defense response; defense response to virus; negative regulation of type I interferon-mediated signaling pathway; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of mitochondrial fission; regulation of protein phosphorylation; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction; type I interferon-mediated signaling pathway","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; ubiquitin-like protein ligase binding","chromatin; cytoplasm; cytosol; ISGF3 complex; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 2","http://www.ncbi.nlm.nih.gov/gene/?term=6773","6773",null,null,null,"396923",null,"P52630","E9QJX9","A0A0G2K9T9","A0A8P0N3D7","O02799","A0A1D5RB61","GO:0000785; GO:0005737; GO:0005829; GO:0070721; GO:0005654; GO:0005634; GO:0005886; GO:0090575","GO:0003677; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0000978; GO:0044389","GO:0019221; GO:0006952; GO:0051607; GO:0060339; GO:0045944; GO:0007259; GO:0042127; GO:0006355; GO:0090140; GO:0001932; GO:0006357; GO:0043434; GO:0007165; GO:0060337","PTHR11801:SF41","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11363|UniProtKB=P52630","P00036; P00047; P00038; P00018"]
["STAT 2 - phospho","Tyr690","STAT2","113","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0650",".CANCER., .CANPTHW., .CCP., .CP., .CSP., .DI., .EGFR., .HEPB., .IMUF., .IMUR., .INFG., .INFM., .INT., .OP., .OPA., .OT., .PDGF., .RTK., .ST., .STAT., .TRASR., .VIR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2","cytokine-mediated signaling pathway; defense response; defense response to virus; negative regulation of type I interferon-mediated signaling pathway; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of mitochondrial fission; regulation of protein phosphorylation; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction; type I interferon-mediated signaling pathway","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; ubiquitin-like protein ligase binding","chromatin; cytoplasm; cytosol; ISGF3 complex; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 2","http://www.ncbi.nlm.nih.gov/gene/?term=6773","6773",null,null,null,"396923",null,"P52630","E9QJX9","A0A0G2K9T9","A0A8P0N3D7","O02799","A0A1D5RB61","GO:0000785; GO:0005737; GO:0005829; GO:0070721; GO:0005654; GO:0005634; GO:0005886; GO:0090575","GO:0003677; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0000978; GO:0044389","GO:0019221; GO:0006952; GO:0051607; GO:0060339; GO:0045944; GO:0007259; GO:0042127; GO:0006355; GO:0090140; GO:0001932; GO:0006357; GO:0043434; GO:0007165; GO:0060337","PTHR11801:SF41","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11363|UniProtKB=P52630","P00036; P00047; P00038; P00018"]
["STAT 3",null,"STAT3","86, 79","rb",null,2,1,1,6,8,8,"# 2692",".AML., .ANG., .APH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .EGFR., .FOXO., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MIG., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TGFB., .TMAT., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Ras Pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3","astrocyte differentiation; cell population proliferation; cellular response to hormone stimulus; cellular response to interleukin-17; cellular response to leptin stimulus; cytokine-mediated signaling pathway; defense response; eating behavior; energy homeostasis; eye photoreceptor cell differentiation; gene expression; glucose homeostasis; growth hormone receptor signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; inflammatory response; interleukin-6-mediated signaling pathway; intracellular receptor signaling pathway; leptin-mediated signaling pathway; mRNA transcription by RNA polymerase II; negative regulation of autophagy; negative regulation of cell population proliferation; negative regulation of gene expression; negative regulation of glycolytic process; negative regulation of neuron migration; negative regulation of primary miRNA processing; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cytokine production involved in inflammatory response; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of metalloendopeptidase activity; positive regulation of miRNA transcription; positive regulation of miRNA-mediated gene silencing; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of vascular endothelial cell proliferation; protein import into nucleus; radial glial cell differentiation; receptor signaling pathway via JAK-STAT; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of feeding behavior; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; response to estradiol; response to leptin; response to peptide hormone; retinal rod cell differentiation; sexual reproduction; signal transduction; somatic stem cell population maintenance; temperature homeostasis; T-helper 17 cell lineage commitment; T-helper 17 type immune response; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway","chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; nuclear receptor activity; primary miRNA binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling adaptor activity; signaling receptor binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex; transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 3","http://www.ncbi.nlm.nih.gov/gene/?term=6774","6774","20848","25125",null,null,null,"P40763","P42227","P52631","A0A8I3N7F2","A0A287AJZ1","A0A1D5Q7H0","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005886; GO:0090575; GO:0005667","GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0042802; GO:0004879; GO:0070878; GO:0005515; GO:0046983; GO:0042803; GO:0019901; GO:0019903; GO:0000978; GO:0061629; GO:0043565; GO:0035591; GO:0005102; GO:0000976","GO:0048708; GO:0008283; GO:0032870; GO:0097398; GO:0044320; GO:0019221; GO:0006952; GO:0042755; GO:0097009; GO:0001754; GO:0010467; GO:0042593; GO:0060396; GO:0060397; GO:0006954; GO:0070102; GO:0030522; GO:0033210; GO:0042789; GO:0010507; GO:0008285; GO:0010629; GO:0045820; GO:2001223; GO:2000635; GO:2000737; GO:0000122; GO:0007399; GO:0016310; GO:0045766; GO:0030335; GO:1900017; GO:0045893; GO:0045648; GO:0010628; GO:0032731; GO:0032733; GO:0032755; GO:0032757; GO:1904685; GO:1902895; GO:2000637; GO:0051092; GO:0045747; GO:0045944; GO:0032760; GO:1905564; GO:0006606; GO:0060019; GO:0007259; GO:0051726; GO:0042127; GO:0006355; GO:0060259; GO:0040014; GO:0006357; GO:0032355; GO:0044321; GO:0043434; GO:0060221; GO:0019953; GO:0007165; GO:0035019; GO:0001659; GO:0072540; GO:0072538; GO:0006366; GO:0007179","PTHR11801:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11364|UniProtKB=P40763","P06959; P00036; P06664; P04393; P00047; P00038; P00005; P00018; P00031"]
["STAT 3 - acetyl","Lys685","STAT3","86, 79","rb",null,2,2,2.1,2.1,7,7,"# 1170",".AML., .ANG., .APH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .FOXO., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MIG., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TGFB., .TMAT., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Ras Pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3","astrocyte differentiation; cell population proliferation; cellular response to hormone stimulus; cellular response to interleukin-17; cellular response to leptin stimulus; cytokine-mediated signaling pathway; defense response; eating behavior; energy homeostasis; eye photoreceptor cell differentiation; gene expression; glucose homeostasis; growth hormone receptor signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; inflammatory response; interleukin-6-mediated signaling pathway; intracellular receptor signaling pathway; leptin-mediated signaling pathway; mRNA transcription by RNA polymerase II; negative regulation of autophagy; negative regulation of cell population proliferation; negative regulation of gene expression; negative regulation of glycolytic process; negative regulation of neuron migration; negative regulation of primary miRNA processing; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cytokine production involved in inflammatory response; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of metalloendopeptidase activity; positive regulation of miRNA transcription; positive regulation of miRNA-mediated gene silencing; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of vascular endothelial cell proliferation; protein import into nucleus; radial glial cell differentiation; receptor signaling pathway via JAK-STAT; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of feeding behavior; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; response to estradiol; response to leptin; response to peptide hormone; retinal rod cell differentiation; sexual reproduction; signal transduction; somatic stem cell population maintenance; temperature homeostasis; T-helper 17 cell lineage commitment; T-helper 17 type immune response; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway","chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; nuclear receptor activity; primary miRNA binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling adaptor activity; signaling receptor binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex; transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 3","http://www.ncbi.nlm.nih.gov/gene/?term=6774","6774","20848","25125",null,null,null,"P40763","P42227","P52631","A0A8I3N7F2","A0A287AJZ1","A0A1D5Q7H0","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005886; GO:0090575; GO:0005667","GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0042802; GO:0004879; GO:0070878; GO:0005515; GO:0046983; GO:0042803; GO:0019901; GO:0019903; GO:0000978; GO:0061629; GO:0043565; GO:0035591; GO:0005102; GO:0000976","GO:0048708; GO:0008283; GO:0032870; GO:0097398; GO:0044320; GO:0019221; GO:0006952; GO:0042755; GO:0097009; GO:0001754; GO:0010467; GO:0042593; GO:0060396; GO:0060397; GO:0006954; GO:0070102; GO:0030522; GO:0033210; GO:0042789; GO:0010507; GO:0008285; GO:0010629; GO:0045820; GO:2001223; GO:2000635; GO:2000737; GO:0000122; GO:0007399; GO:0016310; GO:0045766; GO:0030335; GO:1900017; GO:0045893; GO:0045648; GO:0010628; GO:0032731; GO:0032733; GO:0032755; GO:0032757; GO:1904685; GO:1902895; GO:2000637; GO:0051092; GO:0045747; GO:0045944; GO:0032760; GO:1905564; GO:0006606; GO:0060019; GO:0007259; GO:0051726; GO:0042127; GO:0006355; GO:0060259; GO:0040014; GO:0006357; GO:0032355; GO:0044321; GO:0043434; GO:0060221; GO:0019953; GO:0007165; GO:0035019; GO:0001659; GO:0072540; GO:0072538; GO:0006366; GO:0007179","PTHR11801:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11364|UniProtKB=P40763","P06959; P00036; P06664; P04393; P00047; P00038; P00005; P00018; P00031"]
["STAT 3 - phospho","Ser727","STAT3","86","rb",null,2,1.1000000000000001,8,7,1,2,"# 2415",".AML., .ANG., .APH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .EGFR., .FOXO., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MIG., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TGFB., .TMAT., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Ras Pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3","astrocyte differentiation; cell population proliferation; cellular response to hormone stimulus; cellular response to interleukin-17; cellular response to leptin stimulus; cytokine-mediated signaling pathway; defense response; eating behavior; energy homeostasis; eye photoreceptor cell differentiation; gene expression; glucose homeostasis; growth hormone receptor signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; inflammatory response; interleukin-6-mediated signaling pathway; intracellular receptor signaling pathway; leptin-mediated signaling pathway; mRNA transcription by RNA polymerase II; negative regulation of autophagy; negative regulation of cell population proliferation; negative regulation of gene expression; negative regulation of glycolytic process; negative regulation of neuron migration; negative regulation of primary miRNA processing; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cytokine production involved in inflammatory response; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of metalloendopeptidase activity; positive regulation of miRNA transcription; positive regulation of miRNA-mediated gene silencing; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of vascular endothelial cell proliferation; protein import into nucleus; radial glial cell differentiation; receptor signaling pathway via JAK-STAT; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of feeding behavior; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; response to estradiol; response to leptin; response to peptide hormone; retinal rod cell differentiation; sexual reproduction; signal transduction; somatic stem cell population maintenance; temperature homeostasis; T-helper 17 cell lineage commitment; T-helper 17 type immune response; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway","chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; nuclear receptor activity; primary miRNA binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling adaptor activity; signaling receptor binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex; transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 3","http://www.ncbi.nlm.nih.gov/gene/?term=6774","6774","20848","25125",null,null,null,"P40763","P42227","P52631","A0A8I3N7F2","A0A287AJZ1","A0A1D5Q7H0","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005886; GO:0090575; GO:0005667","GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0042802; GO:0004879; GO:0070878; GO:0005515; GO:0046983; GO:0042803; GO:0019901; GO:0019903; GO:0000978; GO:0061629; GO:0043565; GO:0035591; GO:0005102; GO:0000976","GO:0048708; GO:0008283; GO:0032870; GO:0097398; GO:0044320; GO:0019221; GO:0006952; GO:0042755; GO:0097009; GO:0001754; GO:0010467; GO:0042593; GO:0060396; GO:0060397; GO:0006954; GO:0070102; GO:0030522; GO:0033210; GO:0042789; GO:0010507; GO:0008285; GO:0010629; GO:0045820; GO:2001223; GO:2000635; GO:2000737; GO:0000122; GO:0007399; GO:0016310; GO:0045766; GO:0030335; GO:1900017; GO:0045893; GO:0045648; GO:0010628; GO:0032731; GO:0032733; GO:0032755; GO:0032757; GO:1904685; GO:1902895; GO:2000637; GO:0051092; GO:0045747; GO:0045944; GO:0032760; GO:1905564; GO:0006606; GO:0060019; GO:0007259; GO:0051726; GO:0042127; GO:0006355; GO:0060259; GO:0040014; GO:0006357; GO:0032355; GO:0044321; GO:0043434; GO:0060221; GO:0019953; GO:0007165; GO:0035019; GO:0001659; GO:0072540; GO:0072538; GO:0006366; GO:0007179","PTHR11801:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11364|UniProtKB=P40763","P06959; P00036; P06664; P04393; P00047; P00038; P00005; P00018; P00031"]
["STAT 3 - phospho","Tyr705","STAT3","86, 79","rb",null,2,4,8,8,8,8,"# 2335",".AML., .ANG., .APH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .FOXO., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MIG., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TGFB., .TMAT., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Ras Pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3","astrocyte differentiation; cell population proliferation; cellular response to hormone stimulus; cellular response to interleukin-17; cellular response to leptin stimulus; cytokine-mediated signaling pathway; defense response; eating behavior; energy homeostasis; eye photoreceptor cell differentiation; gene expression; glucose homeostasis; growth hormone receptor signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; inflammatory response; interleukin-6-mediated signaling pathway; intracellular receptor signaling pathway; leptin-mediated signaling pathway; mRNA transcription by RNA polymerase II; negative regulation of autophagy; negative regulation of cell population proliferation; negative regulation of gene expression; negative regulation of glycolytic process; negative regulation of neuron migration; negative regulation of primary miRNA processing; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cytokine production involved in inflammatory response; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of metalloendopeptidase activity; positive regulation of miRNA transcription; positive regulation of miRNA-mediated gene silencing; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of vascular endothelial cell proliferation; protein import into nucleus; radial glial cell differentiation; receptor signaling pathway via JAK-STAT; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of feeding behavior; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; response to estradiol; response to leptin; response to peptide hormone; retinal rod cell differentiation; sexual reproduction; signal transduction; somatic stem cell population maintenance; temperature homeostasis; T-helper 17 cell lineage commitment; T-helper 17 type immune response; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway","chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; nuclear receptor activity; primary miRNA binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling adaptor activity; signaling receptor binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex; transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 3","http://www.ncbi.nlm.nih.gov/gene/?term=6774","6774","20848","25125",null,null,null,"P40763","P42227","P52631","A0A8I3N7F2","A0A287AJZ1","A0A1D5Q7H0","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005886; GO:0090575; GO:0005667","GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0042802; GO:0004879; GO:0070878; GO:0005515; GO:0046983; GO:0042803; GO:0019901; GO:0019903; GO:0000978; GO:0061629; GO:0043565; GO:0035591; GO:0005102; GO:0000976","GO:0048708; GO:0008283; GO:0032870; GO:0097398; GO:0044320; GO:0019221; GO:0006952; GO:0042755; GO:0097009; GO:0001754; GO:0010467; GO:0042593; GO:0060396; GO:0060397; GO:0006954; GO:0070102; GO:0030522; GO:0033210; GO:0042789; GO:0010507; GO:0008285; GO:0010629; GO:0045820; GO:2001223; GO:2000635; GO:2000737; GO:0000122; GO:0007399; GO:0016310; GO:0045766; GO:0030335; GO:1900017; GO:0045893; GO:0045648; GO:0010628; GO:0032731; GO:0032733; GO:0032755; GO:0032757; GO:1904685; GO:1902895; GO:2000637; GO:0051092; GO:0045747; GO:0045944; GO:0032760; GO:1905564; GO:0006606; GO:0060019; GO:0007259; GO:0051726; GO:0042127; GO:0006355; GO:0060259; GO:0040014; GO:0006357; GO:0032355; GO:0044321; GO:0043434; GO:0060221; GO:0019953; GO:0007165; GO:0035019; GO:0001659; GO:0072540; GO:0072538; GO:0006366; GO:0007179","PTHR11801:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11364|UniProtKB=P40763","P06959; P00036; P06664; P04393; P00047; P00038; P00005; P00018; P00031"]
["STAT 3 alpha",null,"STAT3","86","rb",null,2,1,1,2,2,2,"# 1207",".AML., .ANG., .APH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .EGFR., .FOXO., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MIG., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TGFB., .TMAT., .TRASR.","CCKR signaling map; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Ras Pathway; PDGF signaling pathway; JAK/STAT signaling pathway; Angiogenesis; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3","astrocyte differentiation; cell population proliferation; cellular response to hormone stimulus; cellular response to interleukin-17; cellular response to leptin stimulus; cytokine-mediated signaling pathway; defense response; eating behavior; energy homeostasis; eye photoreceptor cell differentiation; gene expression; glucose homeostasis; growth hormone receptor signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; inflammatory response; interleukin-6-mediated signaling pathway; intracellular receptor signaling pathway; leptin-mediated signaling pathway; mRNA transcription by RNA polymerase II; negative regulation of autophagy; negative regulation of cell population proliferation; negative regulation of gene expression; negative regulation of glycolytic process; negative regulation of neuron migration; negative regulation of primary miRNA processing; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cytokine production involved in inflammatory response; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of metalloendopeptidase activity; positive regulation of miRNA transcription; positive regulation of miRNA-mediated gene silencing; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of vascular endothelial cell proliferation; protein import into nucleus; radial glial cell differentiation; receptor signaling pathway via JAK-STAT; regulation of cell cycle; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of feeding behavior; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; response to estradiol; response to leptin; response to peptide hormone; retinal rod cell differentiation; sexual reproduction; signal transduction; somatic stem cell population maintenance; temperature homeostasis; T-helper 17 cell lineage commitment; T-helper 17 type immune response; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway","chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; nuclear receptor activity; primary miRNA binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; signaling adaptor activity; signaling receptor binding; transcription cis-regulatory region binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription regulator complex; transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 3","http://www.ncbi.nlm.nih.gov/gene/?term=6774","6774","20848","25125",null,null,null,"P40763","P42227","P52631","A0A8I3N7F2","A0A287AJZ1","A0A1D5Q7H0","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0005886; GO:0090575; GO:0005667","GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0140297; GO:0042802; GO:0004879; GO:0070878; GO:0005515; GO:0046983; GO:0042803; GO:0019901; GO:0019903; GO:0000978; GO:0061629; GO:0043565; GO:0035591; GO:0005102; GO:0000976","GO:0048708; GO:0008283; GO:0032870; GO:0097398; GO:0044320; GO:0019221; GO:0006952; GO:0042755; GO:0097009; GO:0001754; GO:0010467; GO:0042593; GO:0060396; GO:0060397; GO:0006954; GO:0070102; GO:0030522; GO:0033210; GO:0042789; GO:0010507; GO:0008285; GO:0010629; GO:0045820; GO:2001223; GO:2000635; GO:2000737; GO:0000122; GO:0007399; GO:0016310; GO:0045766; GO:0030335; GO:1900017; GO:0045893; GO:0045648; GO:0010628; GO:0032731; GO:0032733; GO:0032755; GO:0032757; GO:1904685; GO:1902895; GO:2000637; GO:0051092; GO:0045747; GO:0045944; GO:0032760; GO:1905564; GO:0006606; GO:0060019; GO:0007259; GO:0051726; GO:0042127; GO:0006355; GO:0060259; GO:0040014; GO:0006357; GO:0032355; GO:0044321; GO:0043434; GO:0060221; GO:0019953; GO:0007165; GO:0035019; GO:0001659; GO:0072540; GO:0072538; GO:0006366; GO:0007179","PTHR11801:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11364|UniProtKB=P40763","P06959; P00036; P06664; P04393; P00047; P00038; P00005; P00018; P00031"]
["STAT 4",null,"STAT4","81","rb",null,1.1000000000000001,7,7,8,8,8,"# 2830",".CANCER., .CANPTHW., .CCP., .CP., .CSP., .DI., .EGFR., .HEPB., .IMUF., .INFM., .INT., .OP., .OPA., .OT., .PDGF., .RTK., .ST., .STAT., .TCD., .TMAT., .TRASR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4","cytokine-mediated signaling pathway; defense response; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 4","http://www.ncbi.nlm.nih.gov/gene/?term=6775","6775","20849",null,null,null,null,"Q14765","Q3V157",null,null,"A0A287ARF9","A0A1D5QTL2","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0090575","GO:0003677; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0000978","GO:0019221; GO:0006952; GO:0045944; GO:0007259; GO:0042127; GO:0006355; GO:0006357; GO:0043434; GO:0007165","PTHR11801:SF19","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11365|UniProtKB=Q14765","P00036; P00047; P00038; P00018"]
["STAT 4 - phospho","Tyr693","STAT4","81","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1511",".CANCER., .CANPTHW., .CCP., .CP., .CSP., .DI., .EGFR., .HEPB., .IMUF., .INFM., .INT., .OP., .OPA., .OT., .PDGF., .RTK., .ST., .STAT., .TCD., .TMAT., .TRASR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4","cytokine-mediated signaling pathway; defense response; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 4","http://www.ncbi.nlm.nih.gov/gene/?term=6775","6775","20849",null,null,null,null,"Q14765","Q3V157",null,null,"A0A287ARF9","A0A1D5QTL2","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0090575","GO:0003677; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0000978","GO:0019221; GO:0006952; GO:0045944; GO:0007259; GO:0042127; GO:0006355; GO:0006357; GO:0043434; GO:0007165","PTHR11801:SF19","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11365|UniProtKB=Q14765","P00036; P00047; P00038; P00018"]
["STAT 5",null,"STAT5A","90","rb",null,2,2,2,5,2,3,"# 1780",".AML., .CANCER., .CANPTHW., .CCP., .CML., .CP., .CSP., .DI., .EGFR., .HEPB., .IMUF., .INFM., .INT., .NSCLC., .OP., .OPA., .OT., .PDGF., .RTK., .ST., .STAT., .TCD., .TMAT., .TRASR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A","cytokine-mediated signaling pathway; defense response; growth hormone receptor signaling pathway via JAK-STAT; lactation; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; reelin-mediated signaling pathway; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction; taurine metabolic process","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 5A","http://www.ncbi.nlm.nih.gov/gene/?term=6776","6776","20850",null,null,null,"574129","P42229","P42230","A0A8I6A7C8","A0A8I3N824","A0A0A0MY60","A0A1D5QPR1","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0090575","GO:0003677; GO:0003700; GO:0000981; GO:0140297; GO:0005515; GO:0000978","GO:0019221; GO:0006952; GO:0060397; GO:0007595; GO:0043536; GO:0001938; GO:0045944; GO:0007259; GO:0038026; GO:0042127; GO:0006355; GO:0040014; GO:0006357; GO:0043434; GO:0007165; GO:0019530","PTHR11801:SF47","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11366|UniProtKB=P42229","P00036; P00047; P00038; P00018"]
["STAT 5 - phospho","Tyr694","STAT5A","90","rb",null,4,1,1,8,8,8,"TK # 024",".AML., .CANCER., .CANPTHW., .CCP., .CML., .CP., .CSP., .DI., .EGFR., .HEPB., .IMUF., .INFM., .INT., .NSCLC., .OP., .OPA., .OT., .PDGF., .RTK., .ST., .STAT., .TCD., .TMAT., .TRASR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A","cytokine-mediated signaling pathway; defense response; growth hormone receptor signaling pathway via JAK-STAT; lactation; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; reelin-mediated signaling pathway; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction; taurine metabolic process","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 5A","http://www.ncbi.nlm.nih.gov/gene/?term=6776","6776","20850",null,null,null,"574129","P42229","P42230","A0A8I6A7C8","A0A8I3N824","A0A0A0MY60","A0A1D5QPR1","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0090575","GO:0003677; GO:0003700; GO:0000981; GO:0140297; GO:0005515; GO:0000978","GO:0019221; GO:0006952; GO:0060397; GO:0007595; GO:0043536; GO:0001938; GO:0045944; GO:0007259; GO:0038026; GO:0042127; GO:0006355; GO:0040014; GO:0006357; GO:0043434; GO:0007165; GO:0019530","PTHR11801:SF47","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11366|UniProtKB=P42229","P00036; P00047; P00038; P00018"]
["STAT 5 alpha",null,"STAT5A","92","rb",null,1,1,4,4,1,8,"# 1245",".AML., .CANCER., .CANPTHW., .CCP., .CML., .CP., .CSP., .DI., .EGFR., .HEPB., .IMUF., .INFM., .INT., .NSCLC., .OP., .OPA., .OT., .PDGF., .RTK., .ST., .STAT., .TCD., .TMAT., .TRASR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A","cytokine-mediated signaling pathway; defense response; growth hormone receptor signaling pathway via JAK-STAT; lactation; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; reelin-mediated signaling pathway; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction; taurine metabolic process","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding","chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 5A","http://www.ncbi.nlm.nih.gov/gene/?term=6776","6776","20850",null,null,null,"574129","P42229","P42230","A0A8I6A7C8","A0A8I3N824","A0A0A0MY60","A0A1D5QPR1","GO:0000785; GO:0005737; GO:0005829; GO:0005654; GO:0005634; GO:0090575","GO:0003677; GO:0003700; GO:0000981; GO:0140297; GO:0005515; GO:0000978","GO:0019221; GO:0006952; GO:0060397; GO:0007595; GO:0043536; GO:0001938; GO:0045944; GO:0007259; GO:0038026; GO:0042127; GO:0006355; GO:0040014; GO:0006357; GO:0043434; GO:0007165; GO:0019530","PTHR11801:SF47","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11366|UniProtKB=P42229","P00036; P00047; P00038; P00018"]
["STAT 6",null,"STAT6","110","rb",null,2,7,7,7,2.1,2.1,"# 1782",".CANCER., .CANPTHW., .CCP., .CP., .CSP., .DI., .EGFR., .HEPB., .IMU., .IMUF., .IMUR., .INFM., .INT., .OP., .OPA., .OT., .OXS., .PDGF., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TRASR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6","cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cytokine-mediated signaling pathway; defense response; gene expression; growth hormone receptor signaling pathway via JAK-STAT; interleukin-4-mediated signaling pathway; isotype switching to IgE isotypes; mammary gland epithelial cell proliferation; mammary gland morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of type 2 immune response; positive regulation of cold-induced thermogenesis; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of mast cell proliferation; regulation of transcription by RNA polymerase II; response to cytokine; response to peptide hormone; signal transduction; T-helper 1 cell lineage commitment","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator binding","chromatin; cytoplasm; cytosol; membrane raft; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 6","http://www.ncbi.nlm.nih.gov/gene/?term=6778","6778","20852",null,"100142679",null,null,"P42226","P52633","A0A0G2K2M3","A0A0I9QQS7",null,"A0A5F7Z8H8","GO:0000785; GO:0005737; GO:0005829; GO:0045121; GO:0005654; GO:0005634; GO:0090575","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0019903; GO:0000978; GO:0000977; GO:0043565; GO:0001223","GO:0070301; GO:1902170; GO:0019221; GO:0006952; GO:0010467; GO:0060397; GO:0035771; GO:0048289; GO:0033598; GO:0060443; GO:0000122; GO:0002829; GO:0120162; GO:0048295; GO:0045944; GO:0007259; GO:0042127; GO:0006355; GO:0070666; GO:0006357; GO:0034097; GO:0043434; GO:0007165; GO:0002296","PTHR11801:SF48","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11368|UniProtKB=P42226","P00036; P00047; P00038; P00018; P00031"]
["STAT 6 - phospho","Tyr641","STAT6","110","rb",null,7,4,"n/a","n/a","n/a","n/a","# 0654",".CANCER., .CANPTHW., .CCP., .CP., .CSP., .DI., .EGFR., .HEPB., .IMU., .IMUF., .IMUR., .INFM., .INT., .OP., .OPA., .OT., .OXS., .PDGF., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TRASR.","Interleukin signaling pathway; PDGF signaling pathway; JAK/STAT signaling pathway; EGF receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway","SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6","cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cytokine-mediated signaling pathway; defense response; gene expression; growth hormone receptor signaling pathway via JAK-STAT; interleukin-4-mediated signaling pathway; isotype switching to IgE isotypes; mammary gland epithelial cell proliferation; mammary gland morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of type 2 immune response; positive regulation of cold-induced thermogenesis; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of mast cell proliferation; regulation of transcription by RNA polymerase II; response to cytokine; response to peptide hormone; signal transduction; T-helper 1 cell lineage commitment","DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator binding","chromatin; cytoplasm; cytosol; membrane raft; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Jak/Stat signaling / transcription factor","signal transducer and activator of transcription 6","http://www.ncbi.nlm.nih.gov/gene/?term=6778","6778","20852",null,"100142679",null,null,"P42226","P52633","A0A0G2K2M3","A0A0I9QQS7",null,"A0A5F7Z8H8","GO:0000785; GO:0005737; GO:0005829; GO:0045121; GO:0005654; GO:0005634; GO:0090575","GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0019903; GO:0000978; GO:0000977; GO:0043565; GO:0001223","GO:0070301; GO:1902170; GO:0019221; GO:0006952; GO:0010467; GO:0060397; GO:0035771; GO:0048289; GO:0033598; GO:0060443; GO:0000122; GO:0002829; GO:0120162; GO:0048295; GO:0045944; GO:0007259; GO:0042127; GO:0006355; GO:0070666; GO:0006357; GO:0034097; GO:0043434; GO:0007165; GO:0002296","PTHR11801:SF48","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11368|UniProtKB=P42226","P00036; P00047; P00038; P00018; P00031"]
["Stathmin 1",null,"STMN1","19","rb",null,1.1000000000000001,4,8,8,8,8,"# 1247",".CCP., .CCY., .CSP., .GPCR., .GPROT., .IMUR., .MAPK., .OP., .OPA., .RAS., .RTK., .ST., .VIR.","Cytoskeletal regulation by Rho GTPase","STATHMIN","axonogenesis; cell differentiation; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; intracellular signal transduction; microtubule depolymerization; mitotic cytokinesis; mitotic spindle organization; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of microtubule polymerization; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron projection development; regulation of microtubule polymerization or depolymerization; response to virus; signal transduction","protein binding; tubulin binding","cytoplasm; cytoskeleton; cytosol; extracellular exosome; membrane; microtubule; neuron projection","Cytoskeletal signaling","stathmin 1","http://www.ncbi.nlm.nih.gov/gene/?term=3925","3925","16765",null,"478175","494463","719733","P16949","P54227","A0A096MK73","A0A8I3NR64","Q6DUB7","A0A5F7ZEB3","GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0016020; GO:0005874; GO:0043005","GO:0005515; GO:0015631","GO:0007409; GO:0030154; GO:0061436; GO:0048012; GO:0035556; GO:0007019; GO:0000281; GO:0007052; GO:1905098; GO:0031115; GO:0035024; GO:0051497; GO:0070495; GO:0007399; GO:0031175; GO:0031110; GO:0009615; GO:0007165","PTHR10104:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6510|UniProtKB=P16949","P00016"]
["STEP (PTPN5, PTN5)",null,"PTPN5","61, 46, 38, 20","rb",null,1,1,8,8,2.1,1.1000000000000001,"# 0405",".CSP., .MAPK., .OPA., .RTK., .ST.",null,"TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 5","dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; signal transduction","hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; phosphotyrosine residue binding; protein binding; protein kinase binding; protein tyrosine phosphatase activity","cell junction; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleoplasm; plasma membrane","Tyrosine phosphatase","protein tyrosine phosphatase non-receptor type 5","http://www.ncbi.nlm.nih.gov/gene/?term=84867","84867","19259","29644",null,"100524422","708151","P54829","P54830","A0A0G2QC31","A0A8P0NBI3","A0A286ZNQ0","A0A1D5QY35","GO:0030054; GO:0005829; GO:0005783; GO:0005789; GO:0016020; GO:0005654; GO:0005886","GO:0016787; GO:0016791; GO:0004721; GO:0001784; GO:0005515; GO:0019901; GO:0004725","GO:0016311; GO:0035335; GO:0006470; GO:0007165","PTHR46198:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9657|UniProtKB=P54829"]
["SUFU",null,"SUFU","54","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1435",".CANCER., .CANPTHW., .CSP., .DEV., .HHSP., .OP., .OPA., .OT., .ST., .TRASR.","Hedgehog signaling pathway","SUPPRESSOR OF FUSED HOMOLOG","aorta development; coronary vasculature development; cytoplasmic sequestering of transcription factor; determination of left/right symmetry; heart looping; negative regulation of DNA-binding transcription factor activity; negative regulation of hh target transcription factor activity; negative regulation of osteoblast differentiation; negative regulation of protein import into nucleus; negative regulation of smoothened signaling pathway; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; negative regulation of transcription by RNA polymerase II; negative regulation of ubiquitin-dependent protein catabolic process; neural tube closure; regulation of DNA-templated transcription; signal transduction; skin development; smoothened signaling pathway; smoothened signaling pathway involved in dorsal/ventral neural tube patterning; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; smoothened signaling pathway involved in ventral spinal cord interneuron specification; spinal cord dorsal/ventral patterning; ventricular septum development","beta-catenin binding; protein binding; protein kinase binding; transcription corepressor activity","ciliary base; ciliary tip; cilium; cytoplasm; cytosol; GLI-SUFU complex; nucleoplasm; nucleus","Development","SUFU negative regulator of hedgehog signaling","http://www.ncbi.nlm.nih.gov/gene/?term=51684","51684","24069",null,"608531",null,null,"Q9UMX1","Q9Z0P7","A0A8I5ZN76","A0A8I3PTN7","A0A8W4FAC2","F7FIU3","GO:0097546; GO:0097542; GO:0005929; GO:0005737; GO:0005829; GO:1990788; GO:0005654; GO:0005634","GO:0008013; GO:0005515; GO:0019901; GO:0003714","GO:0035904; GO:0060976; GO:0042994; GO:0007368; GO:0001947; GO:0043433; GO:1990787; GO:0045668; GO:0042308; GO:0045879; GO:1901621; GO:0000122; GO:2000059; GO:0001843; GO:0006355; GO:0007165; GO:0043588; GO:0007224; GO:0060831; GO:0021776; GO:0021775; GO:0021513; GO:0003281","PTHR10928:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16466|UniProtKB=Q9UMX1","P00025"]
["Sumo 1",null,"SUMO1","n.a.","rb",null,2,2,8,8,2,2,"# 1199",".CD., .CSP., .DDR., .DREP., .OP., .OT., .P53S., .TRASR.","p53 pathway","SMALL UBIQUITIN-RELATED MODIFIER 1","cellular response to cadmium ion; cellular response to heat; DNA repair; negative regulation of action potential; negative regulation of delayed rectifier potassium channel activity; negative regulation of DNA binding; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of protein import into nucleus; negative regulation of transcription by transcription factor localization; PML body organization; positive regulation of ATPase-coupled calcium transmembrane transporter activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein-containing complex assembly; protein localization to nuclear pore; protein stabilization; protein sumoylation; regulation of calcium ion transmembrane transport; regulation of cardiac muscle cell contraction; regulation of DNA-templated transcription; regulation of protein localization; regulation of protein stability; roof of mouth development","enzyme binding; potassium channel regulator activity; protein binding; protein tag; RNA binding; small protein activating enzyme binding; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding; ubiquitin-specific protease binding","cytoplasm; cytosol; membrane; nuclear body; nuclear membrane; nuclear pore; nuclear speck; nuclear stress granule; nucleolus; nucleoplasm; nucleus; plasma membrane; PML body; voltage-gated potassium channel complex; XY body","Protein targeting (sumoylation)","small ubiquitin like modifier 1","http://www.ncbi.nlm.nih.gov/gene/?term=7341","7341","22218",null,null,null,null,"P63165","P63166","A0A8I5ZPY9",null,null,"A0A5F8AIV5","GO:0005737; GO:0005829; GO:0016020; GO:0016604; GO:0031965; GO:0005643; GO:0016607; GO:0097165; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0016605; GO:0008076; GO:0001741","GO:0019899; GO:0015459; GO:0005515; GO:0031386; GO:0003723; GO:0044388; GO:0008134; GO:0031625; GO:0044389; GO:1990381","GO:0071276; GO:0034605; GO:0006281; GO:0045759; GO:1902260; GO:0043392; GO:0043433; GO:0045892; GO:0042308; GO:0010621; GO:0030578; GO:1901896; GO:0032436; GO:0031334; GO:0090204; GO:0050821; GO:0016925; GO:1903169; GO:0086004; GO:0006355; GO:0032880; GO:0031647; GO:0060021","PTHR10562:SF117","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12502|UniProtKB=P63165","P00059"]
["Sumo 2/3",null,"SUMO3","n.a.","rb",null,2,2,1,1,3,2,"# 1198",".CD., .CSP., .P53S.","p53 pathway","SMALL UBIQUITIN-RELATED MODIFIER 3-RELATED","negative regulation of DNA binding; protein sumoylation; regulation of protein localization to nucleus","protein binding; protein tag; ubiquitin-like protein ligase binding","cytoplasm; kinetochore; nucleoplasm; nucleus; PML body","Protein targeting (sumoylation)","small ubiquitin like modifier 3","http://www.ncbi.nlm.nih.gov/gene/?term=6612","6612",null,null,null,null,null,"P55854",null,null,null,null,null,"GO:0005737; GO:0000776; GO:0005654; GO:0005634; GO:0016605","GO:0005515; GO:0031386; GO:0044389","GO:0043392; GO:0016925; GO:1900180","PTHR10562:SF74","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11124|UniProtKB=P55854","P00059"]
["Superoxiddismutase (Cu/Zn)",null,"SOD1","23, 19","rb",null,1,8,1,1,1,1,"# 1817",".APO., .CD., .CSP., .DI., .DRR., .HUNT., .IMFR., .IMUF., .IMUR., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR.",null,"SUPEROXIDE DISMUTASE [CU-ZN]","aging; anterograde axonal transport; apoptotic process; auditory receptor cell stereocilium organization; cellular iron ion homeostasis; cellular response to ATP; cellular response to cadmium ion; cellular response to oxidative stress; cellular response to potassium ion; ectopic germ cell programmed cell death; embryo implantation; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; muscle cell cellular homeostasis; myeloid cell homeostasis; negative regulation of apoptotic process; negative regulation of cholesterol biosynthetic process; negative regulation of developmental process; negative regulation of inflammatory response; negative regulation of neuron apoptotic process; negative regulation of reproductive process; neurofilament cytoskeleton organization; ovarian follicle development; peripheral nervous system myelin maintenance; placenta development; positive regulation of apoptotic process; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of MAPK cascade; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of phagocytosis; positive regulation of superoxide anion generation; reactive oxygen species metabolic process; regulation of blood pressure; regulation of GTPase activity; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; regulation of organ growth; regulation of protein kinase activity; regulation of T cell differentiation in thymus; relaxation of vascular associated smooth muscle; removal of superoxide radicals; response to amphetamine; response to antibiotic; response to antipsychotic drug; response to axon injury; response to carbon monoxide; response to copper ion; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; response to organic substance; response to oxidative stress; response to reactive oxygen species; response to superoxide; response to xenobiotic stimulus; retina homeostasis; retrograde axonal transport; sensory perception of sound; spermatogenesis; superoxide anion generation; superoxide metabolic process; thymus development; transmission of nerve impulse","antioxidant activity; chaperone binding; copper ion binding; enzyme binding; identical protein binding; ion binding; metal ion binding; oxidoreductase activity; protein binding; protein phosphatase 2B binding; small GTPase binding; superoxide dismutase activity; zinc ion binding","axon cytoplasm; cytoplasm; cytoplasmic vesicle; cytosol; dendrite cytoplasm; dense core granule; extracellular exosome; extracellular region; extracellular space; lysosome; mitochondrial intermembrane space; mitochondrial matrix; mitochondrion; neuron projection; neuronal cell body; nucleoplasm; nucleus; peroxisome; plasma membrane; protein-containing complex; secretory granule","Oxidative stress","superoxide dismutase 1","http://www.ncbi.nlm.nih.gov/gene/?term=6647","6647","20655",null,null,null,null,"P00441","P08228","A0A8I6G9Z6","A0A8I3PS52","A0A2C9F3F0","A0A5F7ZNR5","GO:1904115; GO:0005737; GO:0031410; GO:0005829; GO:0032839; GO:0031045; GO:0070062; GO:0005576; GO:0005615; GO:0005764; GO:0005758; GO:0005759; GO:0005739; GO:0043005; GO:0043025; GO:0005654; GO:0005634; GO:0005777; GO:0005886; GO:0032991; GO:0030141","GO:0016209; GO:0051087; GO:0005507; GO:0019899; GO:0042802; GO:0043167; GO:0046872; GO:0016491; GO:0005515; GO:0030346; GO:0031267; GO:0004784; GO:0008270","GO:0007568; GO:0008089; GO:0006915; GO:0060088; GO:0006879; GO:0071318; GO:0071276; GO:0034599; GO:0035865; GO:0035234; GO:0007566; GO:0006749; GO:0060047; GO:0050665; GO:0007626; GO:0046716; GO:0002262; GO:0043066; GO:0045541; GO:0051093; GO:0050728; GO:0043524; GO:2000242; GO:0060052; GO:0001541; GO:0032287; GO:0001890; GO:0043065; GO:0043085; GO:0001819; GO:0043410; GO:1902177; GO:0050766; GO:0032930; GO:0072593; GO:0008217; GO:0043087; GO:0051881; GO:0040014; GO:0046620; GO:0045859; GO:0033081; GO:0060087; GO:0019430; GO:0001975; GO:0046677; GO:0097332; GO:0048678; GO:0034465; GO:0046688; GO:0045471; GO:0009408; GO:0042542; GO:0031667; GO:0010033; GO:0006979; GO:0000302; GO:0000303; GO:0009410; GO:0001895; GO:0008090; GO:0007605; GO:0007283; GO:0042554; GO:0006801; GO:0048538; GO:0019226","PTHR10003:SF71","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11179|UniProtKB=P00441"]
["Survivin",null,"BIRC5","16","ms",null,1,4,8,8,8,8,"# 0764",".ANG., .APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DEV., .DI., .HEPB., .HIPPO., .OP., .OPA., .OT., .ST., .TRASR.","Angiogenesis","BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5","apoptotic process; cell cycle; cell division; chromosome segregation; mitotic cell cycle; mitotic cytokinesis; mitotic spindle midzone assembly; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of peptidase activity; positive regulation of attachment of mitotic spindle microtubules to kinetochore; positive regulation of cell population proliferation; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of mitotic cytokinesis; positive regulation of mitotic sister chromatid separation; positive regulation of protein phosphorylation; protein phosphorylation; protein-containing complex localization; regulation of apoptotic process; regulation of cell cycle; regulation of endopeptidase activity; sensory perception of sound","chaperone binding; cysteine-type endopeptidase inhibitor activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; enzyme binding; identical protein binding; metal ion binding; microtubule binding; peptidase inhibitor activity; protein binding; small GTPase binding","chromosome; chromosome passenger complex; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; kinetochore; microtubule; microtubule cytoskeleton; midbody; nuclear chromosome; nucleoplasm; nucleus; spindle; spindle microtubule; survivin complex","Apoptosis","baculoviral IAP repeat containing 5","http://www.ncbi.nlm.nih.gov/gene/?term=332","332","11799",null,null,null,null,"O15392","O70201","A0A8I5XV25",null,null,"H9H3J4","GO:0005694; GO:0032133; GO:0000775; GO:0005737; GO:0005856; GO:0005829; GO:0000776; GO:0005874; GO:0015630; GO:0030496; GO:0000228; GO:0005654; GO:0005634; GO:0005819; GO:0005876; GO:1990713","GO:0051087; GO:0004869; GO:0043027; GO:0019899; GO:0042802; GO:0046872; GO:0008017; GO:0030414; GO:0005515; GO:0031267","GO:0006915; GO:0007049; GO:0051301; GO:0007059; GO:0000278; GO:0000281; GO:0051256; GO:0007052; GO:0043066; GO:0043154; GO:0045892; GO:0010466; GO:1902425; GO:0008284; GO:0090267; GO:1903490; GO:1901970; GO:0001934; GO:0006468; GO:0031503; GO:0042981; GO:0051726; GO:0052548; GO:0007605","PTHR46771:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=593|UniProtKB=O15392","P00005"]
["Survivin - phospho","Thr34","BIRC5","18-16","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1032",".ANG., .APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .DEV., .DI., .HEPB., .HIPPO., .OP., .OPA., .OT., .ST., .TRASR.","Angiogenesis","BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5","apoptotic process; cell cycle; cell division; chromosome segregation; mitotic cell cycle; mitotic cytokinesis; mitotic spindle midzone assembly; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of peptidase activity; positive regulation of attachment of mitotic spindle microtubules to kinetochore; positive regulation of cell population proliferation; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of mitotic cytokinesis; positive regulation of mitotic sister chromatid separation; positive regulation of protein phosphorylation; protein phosphorylation; protein-containing complex localization; regulation of apoptotic process; regulation of cell cycle; regulation of endopeptidase activity; sensory perception of sound","chaperone binding; cysteine-type endopeptidase inhibitor activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; enzyme binding; identical protein binding; metal ion binding; microtubule binding; peptidase inhibitor activity; protein binding; small GTPase binding","chromosome; chromosome passenger complex; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; kinetochore; microtubule; microtubule cytoskeleton; midbody; nuclear chromosome; nucleoplasm; nucleus; spindle; spindle microtubule; survivin complex","Apoptosis","baculoviral IAP repeat containing 5","http://www.ncbi.nlm.nih.gov/gene/?term=332","332","11799",null,null,null,null,"O15392","O70201","A0A8I5XV25",null,null,"H9H3J4","GO:0005694; GO:0032133; GO:0000775; GO:0005737; GO:0005856; GO:0005829; GO:0000776; GO:0005874; GO:0015630; GO:0030496; GO:0000228; GO:0005654; GO:0005634; GO:0005819; GO:0005876; GO:1990713","GO:0051087; GO:0004869; GO:0043027; GO:0019899; GO:0042802; GO:0046872; GO:0008017; GO:0030414; GO:0005515; GO:0031267","GO:0006915; GO:0007049; GO:0051301; GO:0007059; GO:0000278; GO:0000281; GO:0051256; GO:0007052; GO:0043066; GO:0043154; GO:0045892; GO:0010466; GO:1902425; GO:0008284; GO:0090267; GO:1903490; GO:1901970; GO:0001934; GO:0006468; GO:0031503; GO:0042981; GO:0051726; GO:0052548; GO:0007605","PTHR46771:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=593|UniProtKB=O15392","P00005"]
["SUZ12",null,"SUZ12","83","rb",null,1,1,4,4,5,8,"# 1453",".CCP., .CP., .OP., .OT., .TRASR., .UBI.",null,"POLYCOMB PROTEIN SUZ12","cell population proliferation; chromatin organization; dosage compensation by inactivation of X chromosome; facultative heterochromatin formation; histone methylation; histone ubiquitination; negative regulation of cell differentiation; negative regulation of transcription by RNA polymerase II; oligodendrocyte differentiation; positive regulation of cell population proliferation","chromatin binding; chromatin DNA binding; enzyme activator activity; histone methyltransferase activity; lncRNA binding; metal ion binding; methylated histone binding; promoter-specific chromatin binding; protein binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription corepressor binding","chromatin silencing complex; ESC/E(Z) complex; nuclear body; nucleolus; nucleoplasm; nucleus; protein-DNA complex; ribonucleoprotein complex; sex chromatin","Chromatin regulation / epigenetics","SUZ12 polycomb repressive complex 2 subunit","http://www.ncbi.nlm.nih.gov/gene/?term=23512","23512","52615",null,null,"100294712","717834","Q15022","Q80U70","A0A0G2JV08","A0A8I3NHG6","A0A287A167","A0A5F8A8X4","GO:0005677; GO:0035098; GO:0016604; GO:0005730; GO:0005654; GO:0005634; GO:0032993; GO:1990904; GO:0001739","GO:0003682; GO:0031490; GO:0008047; GO:0042054; GO:0106222; GO:0046872; GO:0035064; GO:1990841; GO:0005515; GO:0003723; GO:0000978; GO:0043565; GO:0001222","GO:0008283; GO:0006325; GO:0009048; GO:0140718; GO:0016571; GO:0016574; GO:0045596; GO:0000122; GO:0048709; GO:0008284","PTHR22597:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=17101|UniProtKB=Q15022"]
["Synapsin-1",null,"SYN1","77","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2051",null,"Synaptic_vesicle_trafficking","SYNAPSIN-1","chemical synaptic transmission; neuron development; neurotransmitter secretion; regulation of neurotransmitter secretion; regulation of synaptic vesicle cycle; regulation of synaptic vesicle exocytosis; synapse organization; synaptic vesicle clustering; synaptic vesicle cycle","actin binding; ATP binding; calcium-dependent protein binding; cytoskeletal protein-membrane anchor activity; identical protein binding; protein binding; protein kinase binding","axon; cell body; cell projection; cytoplasmic vesicle; cytoskeleton; cytosol; dendrite; extrinsic component of synaptic vesicle membrane; Golgi apparatus; intracellular organelle; postsynaptic density; presynapse; presynaptic active zone; Schaffer collateral - CA1 synapse; synapse; synaptic vesicle; synaptic vesicle membrane; synaptonemal complex",null,"synapsin I","http://www.ncbi.nlm.nih.gov/gene/?term=6853","6853","20964","24949","100685486","100216310",null,"P17600","O88935","P09951","A0A8I3QAQ3","B7TY10","F6VRW8","GO:0030424; GO:0044297; GO:0042995; GO:0031410; GO:0005856; GO:0005829; GO:0030425; GO:0098850; GO:0005794; GO:0043229; GO:0014069; GO:0098793; GO:0048786; GO:0098685; GO:0045202; GO:0008021; GO:0030672; GO:0000795","GO:0003779; GO:0005524; GO:0048306; GO:0106006; GO:0042802; GO:0005515; GO:0019901","GO:0007268; GO:0048666; GO:0007269; GO:0046928; GO:0098693; GO:2000300; GO:0050808; GO:0097091; GO:0099504","PTHR10841:SF24","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11494|UniProtKB=P17600","P05734"]
["Synuclein alpha",null,"SNCA","18","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1991",".ALZ., .APH., .APO., .CD., .CSP., .DI., .DRR., .GPCR., .GPROT., .IIR., .IMFR., .IMUR., .OP., .OPA., .OT., .OXS., .PARK., .SREME., .ST., .TRASR.","Parkinson disease","ALPHA-SYNUCLEIN","activation of cysteine-type endopeptidase activity involved in apoptotic process; adult locomotory behavior; amyloid fibril formation; calcium ion homeostasis; cellular response to copper ion; cellular response to epinephrine stimulus; cellular response to oxidative stress; chemical synaptic transmission; dopamine biosynthetic process; dopamine metabolic process; dopamine uptake involved in synaptic transmission; excitatory postsynaptic potential; fatty acid metabolic process; localization; long-term synaptic potentiation; membrane organization; microglial cell activation; mitochondrial ATP synthesis coupled electron transport; mitochondrial membrane organization; negative regulation of apoptotic process; negative regulation of chaperone-mediated autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of dopamine uptake involved in synaptic transmission; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of mitochondrial electron transport, NADH to ubiquinone; negative regulation of monooxygenase activity; negative regulation of neuron apoptotic process; negative regulation of neuron death; negative regulation of norepinephrine uptake; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase activity; negative regulation of serotonin uptake; negative regulation of thrombin-activated receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transporter activity; neuron apoptotic process; neurotransmitter secretion; neutral lipid metabolic process; phospholipid metabolic process; positive regulation of apoptotic process; positive regulation of endocytosis; positive regulation of exocytosis; positive regulation of glutathione peroxidase activity; positive regulation of hydrogen peroxide catabolic process; positive regulation of inflammatory response; positive regulation of inositol phosphate biosynthetic process; positive regulation of neuron death; positive regulation of neurotransmitter secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of SNARE complex assembly; positive regulation of synaptic transmission; protein complex oligomerization; protein destabilization; protein tetramerization; receptor internalization; regulation of acyl-CoA biosynthetic process; regulation of dopamine secretion; regulation of glutamate secretion; regulation of locomotion; regulation of long-term neuronal synaptic plasticity; regulation of macrophage activation; regulation of neuron death; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; regulation of norepinephrine uptake; regulation of phospholipase activity; regulation of presynapse assembly; regulation of reactive oxygen species biosynthetic process; regulation of reactive oxygen species metabolic process; regulation of synaptic vesicle recycling; regulation of transmembrane transporter activity; response to interleukin-1; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; response to type II interferon; response to xenobiotic stimulus; SNARE complex assembly; supramolecular fiber organization; synapse organization; synaptic transmission, dopaminergic; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synaptic vesicle priming; synaptic vesicle transport","actin binding; alpha-tubulin binding; calcium ion binding; copper ion binding; cuprous ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; dynein complex binding; fatty acid binding; ferrous iron binding; histone binding; Hsp70 protein binding; identical protein binding; kinesin binding; lipid binding; magnesium ion binding; metal ion binding; molecular adaptor activity; oxidoreductase activity; phospholipase D inhibitor activity; phospholipid binding; phosphoprotein binding; protein binding; protein kinase inhibitor activity; SNARE binding; tau protein binding; transcription cis-regulatory region binding; zinc ion binding","actin cytoskeleton; axon; axon terminus; cell cortex; cell projection; cytoplasm; cytoskeleton; cytosol; extracellular region; extracellular space; growth cone; inclusion body; lysosome; membrane; mitochondrion; neuronal cell body; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane; postsynapse; protein-containing complex; supramolecular fiber; synapse; synaptic vesicle membrane",null,"synuclein alpha","http://www.ncbi.nlm.nih.gov/gene/?term=6622","6622","20617","29219",null,null,"706985","P37840","O55042","P37377","A0A8I3NZ19","A0A5G2R2I6","P61143","GO:0015629; GO:0030424; GO:0043679; GO:0005938; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0005576; GO:0005615; GO:0030426; GO:0016234; GO:0005764; GO:0016020; GO:0005739; GO:0043025; GO:0005634; GO:0048471; GO:0005886; GO:0031092; GO:0098794; GO:0032991; GO:0099512; GO:0045202; GO:0030672","GO:0003779; GO:0043014; GO:0005509; GO:0005507; GO:1903136; GO:0043027; GO:0070840; GO:0005504; GO:0008198; GO:0042393; GO:0030544; GO:0042802; GO:0019894; GO:0008289; GO:0000287; GO:0046872; GO:0060090; GO:0016491; GO:0060961; GO:0005543; GO:0051219; GO:0005515; GO:0004860; GO:0000149; GO:0048156; GO:0000976; GO:0008270","GO:0006919; GO:0008344; GO:1990000; GO:0055074; GO:0071280; GO:0071872; GO:0034599; GO:0007268; GO:0042416; GO:0042417; GO:0051583; GO:0060079; GO:0006631; GO:0051179; GO:0060291; GO:0061024; GO:0001774; GO:0042775; GO:0007006; GO:0043066; GO:1904715; GO:0043154; GO:0051585; GO:0045920; GO:0035067; GO:0031115; GO:1902957; GO:0032769; GO:0043524; GO:1901215; GO:0051622; GO:0010642; GO:0006469; GO:0051612; GO:0070495; GO:0000122; GO:0032410; GO:0051402; GO:0007269; GO:0006638; GO:0006644; GO:0043065; GO:0045807; GO:0045921; GO:1903284; GO:1903285; GO:0050729; GO:0060732; GO:1901216; GO:0001956; GO:0033138; GO:0071902; GO:0001921; GO:0051281; GO:0035543; GO:0050806; GO:0051259; GO:0031648; GO:0051262; GO:0031623; GO:0050812; GO:0014059; GO:0014048; GO:0040012; GO:0048169; GO:0043030; GO:1901214; GO:0048168; GO:0046928; GO:0051621; GO:0010517; GO:1905606; GO:1903426; GO:2000377; GO:1903421; GO:0022898; GO:0070555; GO:0010040; GO:0032496; GO:0032026; GO:0034341; GO:0009410; GO:0035493; GO:0097435; GO:0050808; GO:0001963; GO:0048488; GO:0016079; GO:0016082; GO:0048489","PTHR13820:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11138|UniProtKB=P37840","P00049"]
["TACE",null,"ADAM17","135","rb",null,1,1,8,1,1.1000000000000001,8,"# 1428",".ALZ., .BCR., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .DI., .DRR., .EGFR., .HIF., .IMU., .IMUF., .IMUR., .INFM., .LMIG., .MIG., .NOTCH., .OP., .OPA., .OT., .RTK., .SREME., .ST., .TCR., .TGFB., .TNF., .TRASR.","Notch signaling pathway; Alzheimer disease-presenilin pathway; Alzheimer disease-amyloid secretase pathway","DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17","amyloid precursor protein catabolic process; B cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell motility; cellular response to high density lipoprotein particle stimulus; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; germinal center formation; membrane protein ectodomain proteolysis; negative regulation of cold-induced thermogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; neutrophil mediated immunity; Notch receptor processing; Notch signaling pathway; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of chemokine production; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of leukocyte chemotaxis; positive regulation of protein phosphorylation; positive regulation of T cell chemotaxis; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of vascular endothelial cell proliferation; protein processing; proteolysis; receptor transactivation; regulation of mast cell apoptotic process; response to hypoxia; response to lipopolysaccharide; response to stimulus; response to xenobiotic stimulus; spleen development; T cell differentiation in thymus; wound healing, spreading of epidermal cells","endopeptidase activity; hydrolase activity; integrin binding; interleukin-6 receptor binding; metal ion binding; metalloendopeptidase activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; metallopeptidase activity; Notch binding; PDZ domain binding; peptidase activity; protein binding; SH3 domain binding","actin cytoskeleton; apical plasma membrane; cell surface; cell-cell junction; cytoplasm; cytosol; endoplasmic reticulum lumen; focal adhesion; Golgi membrane; membrane; membrane raft; plasma membrane; ruffle membrane","Development","ADAM metallopeptidase domain 17","http://www.ncbi.nlm.nih.gov/gene/?term=6868","6868","11491",null,null,null,null,"P78536","Q9Z0F8","A0A8I6A811","A0A8I3PPC7","A0A287BEA0","A0A1D5Q458","GO:0015629; GO:0016324; GO:0009986; GO:0005911; GO:0005737; GO:0005829; GO:0005788; GO:0005925; GO:0000139; GO:0016020; GO:0045121; GO:0005886; GO:0032587","GO:0004175; GO:0016787; GO:0005178; GO:0005138; GO:0046872; GO:0004222; GO:1902945; GO:0008237; GO:0005112; GO:0030165; GO:0008233; GO:0005515; GO:0017124","GO:0042987; GO:0030183; GO:0007155; GO:0033627; GO:0048870; GO:0071403; GO:0050830; GO:0007173; GO:0002467; GO:0006509; GO:0120163; GO:0030512; GO:0002446; GO:0007220; GO:0007219; GO:0043536; GO:0030307; GO:0030335; GO:0008284; GO:0032722; GO:0045737; GO:0045741; GO:1900087; GO:0002690; GO:0001934; GO:0010820; GO:0030511; GO:1903265; GO:1905564; GO:0016485; GO:0006508; GO:0035624; GO:0033025; GO:0001666; GO:0032496; GO:0050896; GO:0009410; GO:0048536; GO:0033077; GO:0035313","PTHR45702:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=195|UniProtKB=P78536","P00045; P00004; P00003"]
["Tag(CGY)FP",null,null,"27","rb",null,7,7,5,6,7,5,"# 1565",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"n.a."]
["TAK1",null,"MAP3K7","82-78","rb",null,2.1,1,8,8,8,8,"# 2795",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .DI., .HEPB., .IMUF., .INFM., .INT., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .RTK., .SREME., .ST., .TCR., .TGFB., .TNF., .TOLL., .TRASR., .WNT.","p38 MAPK pathway; TGF-beta signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7","activation of NF-kappaB-inducing kinase activity; anoikis; apoptotic process; cytosolic pattern recognition receptor signaling pathway; Fc-epsilon receptor signaling pathway; histone H3 acetylation; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; interleukin-1-mediated signaling pathway; JNK cascade; MAPK cascade; MyD88-dependent toll-like receptor signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; p38MAPK cascade; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-2 production; positive regulation of JUN kinase activity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell cytokine production; protein phosphorylation; response to stimulus; signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; transforming growth factor beta receptor signaling pathway","ATP binding; identical protein binding; kinase activity; magnesium ion binding; MAP kinase activity; MAP kinase kinase kinase activity; MAP kinase kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; receptor tyrosine kinase binding; scaffold protein binding; transferase activity","ATAC complex; cytoplasm; cytosol; endosome membrane; IkappaB kinase complex; membrane; nucleus; plasma membrane","MAPK signaling","mitogen-activated protein kinase kinase kinase 7","http://www.ncbi.nlm.nih.gov/gene/?term=6885","6885","26409","313121","102156745",null,null,"O43318","Q62073","P0C8E4","A0A8I3MWV5",null,"F7GDY4","GO:0140672; GO:0005737; GO:0005829; GO:0010008; GO:0008385; GO:0016020; GO:0005634; GO:0005886","GO:0005524; GO:0042802; GO:0016301; GO:0000287; GO:0004707; GO:0004709; GO:0008349; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0030971; GO:0097110; GO:0016740","GO:0007250; GO:0043276; GO:0006915; GO:0002753; GO:0038095; GO:0043966; GO:0007249; GO:0007252; GO:0070498; GO:0007254; GO:0000165; GO:0002755; GO:0070423; GO:0038066; GO:0016310; GO:0043123; GO:0032743; GO:0043507; GO:0016239; GO:0043410; GO:0051092; GO:0002726; GO:0006468; GO:0050896; GO:0007165; GO:0002223; GO:0051403; GO:0050852; GO:0007179","PTHR46716:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6859|UniProtKB=O43318","P05918; P00052; P00036; P06664; P00054; P00031; P00057"]
["TAK1 - phospho","Ser412","MAP3K7","82","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2647",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .DI., .HEPB., .IMUF., .INFM., .INT., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .RTK., .SREME., .ST., .TCR., .TGFB., .TNF., .TOLL., .TRASR., .WNT.","p38 MAPK pathway; TGF-beta signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7","activation of NF-kappaB-inducing kinase activity; anoikis; apoptotic process; cytosolic pattern recognition receptor signaling pathway; Fc-epsilon receptor signaling pathway; histone H3 acetylation; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; interleukin-1-mediated signaling pathway; JNK cascade; MAPK cascade; MyD88-dependent toll-like receptor signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; p38MAPK cascade; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-2 production; positive regulation of JUN kinase activity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell cytokine production; protein phosphorylation; response to stimulus; signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; transforming growth factor beta receptor signaling pathway","ATP binding; identical protein binding; kinase activity; magnesium ion binding; MAP kinase activity; MAP kinase kinase kinase activity; MAP kinase kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; receptor tyrosine kinase binding; scaffold protein binding; transferase activity","ATAC complex; cytoplasm; cytosol; endosome membrane; IkappaB kinase complex; membrane; nucleus; plasma membrane","MAPK signaling","mitogen-activated protein kinase kinase kinase 7","http://www.ncbi.nlm.nih.gov/gene/?term=6885","6885","26409","313121","102156745",null,null,"O43318","Q62073","P0C8E4","A0A8I3MWV5",null,"F7GDY4","GO:0140672; GO:0005737; GO:0005829; GO:0010008; GO:0008385; GO:0016020; GO:0005634; GO:0005886","GO:0005524; GO:0042802; GO:0016301; GO:0000287; GO:0004707; GO:0004709; GO:0008349; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0030971; GO:0097110; GO:0016740","GO:0007250; GO:0043276; GO:0006915; GO:0002753; GO:0038095; GO:0043966; GO:0007249; GO:0007252; GO:0070498; GO:0007254; GO:0000165; GO:0002755; GO:0070423; GO:0038066; GO:0016310; GO:0043123; GO:0032743; GO:0043507; GO:0016239; GO:0043410; GO:0051092; GO:0002726; GO:0006468; GO:0050896; GO:0007165; GO:0002223; GO:0051403; GO:0050852; GO:0007179","PTHR46716:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6859|UniProtKB=O43318","P05918; P00052; P00036; P06664; P00054; P00031; P00057"]
["TAK1 - phospho","Thr187","MAP3K7","82","rb",null,7,4,"n/a","n/a","n/a","n/a","TK # 091",".AMPK., .APH., .APO., .CD., .CSP., .DEV., .DI., .HEPB., .IMUF., .INFM., .INT., .JNK., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .RTK., .SREME., .ST., .TCR., .TGFB., .TNF., .TOLL., .TRASR., .WNT.","p38 MAPK pathway; TGF-beta signaling pathway; Interleukin signaling pathway; Gonadotropin releasing hormone receptor pathway; Toll receptor signaling pathway; Inflammation mediated by chemokine and cytokine signaling pathway; Wnt signaling pathway","MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7","activation of NF-kappaB-inducing kinase activity; anoikis; apoptotic process; cytosolic pattern recognition receptor signaling pathway; Fc-epsilon receptor signaling pathway; histone H3 acetylation; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; interleukin-1-mediated signaling pathway; JNK cascade; MAPK cascade; MyD88-dependent toll-like receptor signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; p38MAPK cascade; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-2 production; positive regulation of JUN kinase activity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell cytokine production; protein phosphorylation; response to stimulus; signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; transforming growth factor beta receptor signaling pathway","ATP binding; identical protein binding; kinase activity; magnesium ion binding; MAP kinase activity; MAP kinase kinase kinase activity; MAP kinase kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; receptor tyrosine kinase binding; scaffold protein binding; transferase activity","ATAC complex; cytoplasm; cytosol; endosome membrane; IkappaB kinase complex; membrane; nucleus; plasma membrane","MAPK signaling","mitogen-activated protein kinase kinase kinase 7","http://www.ncbi.nlm.nih.gov/gene/?term=6885","6885","26409","313121","102156745",null,null,"O43318","Q62073","P0C8E4","A0A8I3MWV5",null,"F7GDY4","GO:0140672; GO:0005737; GO:0005829; GO:0010008; GO:0008385; GO:0016020; GO:0005634; GO:0005886","GO:0005524; GO:0042802; GO:0016301; GO:0000287; GO:0004707; GO:0004709; GO:0008349; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0030971; GO:0097110; GO:0016740","GO:0007250; GO:0043276; GO:0006915; GO:0002753; GO:0038095; GO:0043966; GO:0007249; GO:0007252; GO:0070498; GO:0007254; GO:0000165; GO:0002755; GO:0070423; GO:0038066; GO:0016310; GO:0043123; GO:0032743; GO:0043507; GO:0016239; GO:0043410; GO:0051092; GO:0002726; GO:0006468; GO:0050896; GO:0007165; GO:0002223; GO:0051403; GO:0050852; GO:0007179","PTHR46716:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6859|UniProtKB=O43318","P05918; P00052; P00036; P06664; P00054; P00031; P00057"]
["Tau",null,"MAPT","68-50","ms",null,7,5,"n/a","n/a","n/a","n/a","# 0527",".ALZ., .APH., .APO., .CCP., .CD., .CP., .CSP., .DDR., .DI., .IMFR., .IMUR., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR.",null,"MICROTUBULE-ASSOCIATED PROTEIN TAU","activation of cysteine-type endopeptidase activity involved in apoptotic process; amyloid fibril formation; astrocyte activation; axon development; axonal transport; axonal transport of mitochondrion; cell-cell signaling; cellular response to brain-derived neurotrophic factor stimulus; cellular response to heat; cellular response to nerve growth factor stimulus; cellular response to reactive oxygen species; central nervous system neuron development; cytoplasmic microtubule organization; generation of neurons; internal protein amino acid acetylation; intracellular distribution of mitochondria; memory; microglial cell activation; microtubule cytoskeleton organization; microtubule polymerization; negative regulation of establishment of protein localization to mitochondrion; negative regulation of gene expression; negative regulation of kinase activity; negative regulation of mitochondrial fission; negative regulation of mitochondrial membrane potential; negative regulation of tubulin deacetylation; neurofibrillary tangle assembly; neuron projection development; plus-end-directed organelle transport along microtubule; positive regulation of axon extension; positive regulation of diacylglycerol kinase activity; positive regulation of microtubule polymerization; positive regulation of neuron death; positive regulation of protein localization; positive regulation of protein localization to synapse; positive regulation of superoxide anion generation; protein polymerization; regulation of autophagy; regulation of calcium-mediated signaling; regulation of cellular response to heat; regulation of chromosome organization; regulation of long-term synaptic depression; regulation of microtubule cytoskeleton organization; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of mitochondrial fission; regulation of response to DNA damage stimulus; regulation of synaptic plasticity; response to lead ion; rRNA metabolic process; stress granule assembly; supramolecular fiber organization; synapse organization","actin binding; apolipoprotein binding; chaperone binding; DNA binding; double-stranded DNA binding; dynactin binding; enzyme binding; histone-dependent DNA binding; Hsp90 protein binding; identical protein binding; lipoprotein particle binding; microtubule binding; microtubule lateral binding; minor groove of adenine-thymine-rich DNA binding; phosphatidylinositol binding; phosphatidylinositol bisphosphate binding; protein binding; protein kinase binding; protein phosphatase 2A binding; protein-macromolecule adaptor activity; RNA binding; sequence-specific DNA binding; SH3 domain binding; single-stranded DNA binding; tubulin binding","axolemma; axon; axon cytoplasm; cell body; cell projection; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; dendrite; dendritic spine; extracellular region; glial cell projection; growth cone; main axon; membrane; membrane raft; microtubule; microtubule cytoskeleton; mitochondrion; neurofibrillary tangle; neuron projection; neuronal cell body; nuclear periphery; nuclear speck; nucleus; plasma membrane; somatodendritic compartment; tubulin complex","Neurodegenerative disease","microtubule associated protein tau","http://www.ncbi.nlm.nih.gov/gene/?term=4137","4137","17762",null,null,null,"574327","P10636","P10637","A0A8I5YBN3","A0A8P0NFN5","A0A286ZJ75","P57786","GO:0030673; GO:0030424; GO:1904115; GO:0044297; GO:0042995; GO:0005737; GO:0036464; GO:0005856; GO:0005829; GO:0030425; GO:0043197; GO:0005576; GO:0097386; GO:0030426; GO:0044304; GO:0016020; GO:0045121; GO:0005874; GO:0015630; GO:0005739; GO:0097418; GO:0043005; GO:0043025; GO:0034399; GO:0016607; GO:0005634; GO:0005886; GO:0036477; GO:0045298","GO:0003779; GO:0034185; GO:0051087; GO:0003677; GO:0003690; GO:0034452; GO:0019899; GO:0099077; GO:0051879; GO:0042802; GO:0071813; GO:0008017; GO:0099609; GO:0003680; GO:0035091; GO:1902936; GO:0005515; GO:0019901; GO:0051721; GO:0030674; GO:0003723; GO:0043565; GO:0017124; GO:0003697; GO:0015631","GO:0006919; GO:1990000; GO:0048143; GO:0061564; GO:0098930; GO:0019896; GO:0007267; GO:1990416; GO:0034605; GO:1990090; GO:0034614; GO:0021954; GO:0031122; GO:0048699; GO:0006475; GO:0048312; GO:0007613; GO:0001774; GO:0000226; GO:0046785; GO:1903748; GO:0010629; GO:0033673; GO:0090258; GO:0010917; GO:1904428; GO:1902988; GO:0031175; GO:0072386; GO:0045773; GO:1905689; GO:0031116; GO:1901216; GO:1903829; GO:1902474; GO:0032930; GO:0051258; GO:0010506; GO:0050848; GO:1900034; GO:0033044; GO:1900452; GO:0070507; GO:0031113; GO:0031110; GO:0090140; GO:2001020; GO:0048167; GO:0010288; GO:0016072; GO:0034063; GO:0097435; GO:0050808","PTHR11501:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6893|UniProtKB=P10636"]
["Tau - phospho","Ser202","MAPT","80-50","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2218",".ALZ., .APH., .APO., .CCP., .CD., .CP., .CSP., .DDR., .DI., .IMFR., .IMUR., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR.",null,"MICROTUBULE-ASSOCIATED PROTEIN TAU","activation of cysteine-type endopeptidase activity involved in apoptotic process; amyloid fibril formation; astrocyte activation; axon development; axonal transport; axonal transport of mitochondrion; cell-cell signaling; cellular response to brain-derived neurotrophic factor stimulus; cellular response to heat; cellular response to nerve growth factor stimulus; cellular response to reactive oxygen species; central nervous system neuron development; cytoplasmic microtubule organization; generation of neurons; internal protein amino acid acetylation; intracellular distribution of mitochondria; memory; microglial cell activation; microtubule cytoskeleton organization; microtubule polymerization; negative regulation of establishment of protein localization to mitochondrion; negative regulation of gene expression; negative regulation of kinase activity; negative regulation of mitochondrial fission; negative regulation of mitochondrial membrane potential; negative regulation of tubulin deacetylation; neurofibrillary tangle assembly; neuron projection development; plus-end-directed organelle transport along microtubule; positive regulation of axon extension; positive regulation of diacylglycerol kinase activity; positive regulation of microtubule polymerization; positive regulation of neuron death; positive regulation of protein localization; positive regulation of protein localization to synapse; positive regulation of superoxide anion generation; protein polymerization; regulation of autophagy; regulation of calcium-mediated signaling; regulation of cellular response to heat; regulation of chromosome organization; regulation of long-term synaptic depression; regulation of microtubule cytoskeleton organization; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of mitochondrial fission; regulation of response to DNA damage stimulus; regulation of synaptic plasticity; response to lead ion; rRNA metabolic process; stress granule assembly; supramolecular fiber organization; synapse organization","actin binding; apolipoprotein binding; chaperone binding; DNA binding; double-stranded DNA binding; dynactin binding; enzyme binding; histone-dependent DNA binding; Hsp90 protein binding; identical protein binding; lipoprotein particle binding; microtubule binding; microtubule lateral binding; minor groove of adenine-thymine-rich DNA binding; phosphatidylinositol binding; phosphatidylinositol bisphosphate binding; protein binding; protein kinase binding; protein phosphatase 2A binding; protein-macromolecule adaptor activity; RNA binding; sequence-specific DNA binding; SH3 domain binding; single-stranded DNA binding; tubulin binding","axolemma; axon; axon cytoplasm; cell body; cell projection; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; dendrite; dendritic spine; extracellular region; glial cell projection; growth cone; main axon; membrane; membrane raft; microtubule; microtubule cytoskeleton; mitochondrion; neurofibrillary tangle; neuron projection; neuronal cell body; nuclear periphery; nuclear speck; nucleus; plasma membrane; somatodendritic compartment; tubulin complex",null,"microtubule associated protein tau","http://www.ncbi.nlm.nih.gov/gene/?term=4137","4137","17762",null,null,null,"574327","P10636","P10637","A0A8I5YBN3","A0A8P0NFN5","A0A286ZJ75","P57786","GO:0030673; GO:0030424; GO:1904115; GO:0044297; GO:0042995; GO:0005737; GO:0036464; GO:0005856; GO:0005829; GO:0030425; GO:0043197; GO:0005576; GO:0097386; GO:0030426; GO:0044304; GO:0016020; GO:0045121; GO:0005874; GO:0015630; GO:0005739; GO:0097418; GO:0043005; GO:0043025; GO:0034399; GO:0016607; GO:0005634; GO:0005886; GO:0036477; GO:0045298","GO:0003779; GO:0034185; GO:0051087; GO:0003677; GO:0003690; GO:0034452; GO:0019899; GO:0099077; GO:0051879; GO:0042802; GO:0071813; GO:0008017; GO:0099609; GO:0003680; GO:0035091; GO:1902936; GO:0005515; GO:0019901; GO:0051721; GO:0030674; GO:0003723; GO:0043565; GO:0017124; GO:0003697; GO:0015631","GO:0006919; GO:1990000; GO:0048143; GO:0061564; GO:0098930; GO:0019896; GO:0007267; GO:1990416; GO:0034605; GO:1990090; GO:0034614; GO:0021954; GO:0031122; GO:0048699; GO:0006475; GO:0048312; GO:0007613; GO:0001774; GO:0000226; GO:0046785; GO:1903748; GO:0010629; GO:0033673; GO:0090258; GO:0010917; GO:1904428; GO:1902988; GO:0031175; GO:0072386; GO:0045773; GO:1905689; GO:0031116; GO:1901216; GO:1903829; GO:1902474; GO:0032930; GO:0051258; GO:0010506; GO:0050848; GO:1900034; GO:0033044; GO:1900452; GO:0070507; GO:0031113; GO:0031110; GO:0090140; GO:2001020; GO:0048167; GO:0010288; GO:0016072; GO:0034063; GO:0097435; GO:0050808","PTHR11501:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6893|UniProtKB=P10636"]
["Tau - phospho","Ser262","MAPT","90-70","rb",null,1,6,"n/a","n/a","n/a","n/a","# 2230",".ALZ., .APH., .APO., .CCP., .CD., .CP., .CSP., .DDR., .DI., .IMFR., .IMUR., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR.",null,"MICROTUBULE-ASSOCIATED PROTEIN TAU","activation of cysteine-type endopeptidase activity involved in apoptotic process; amyloid fibril formation; astrocyte activation; axon development; axonal transport; axonal transport of mitochondrion; cell-cell signaling; cellular response to brain-derived neurotrophic factor stimulus; cellular response to heat; cellular response to nerve growth factor stimulus; cellular response to reactive oxygen species; central nervous system neuron development; cytoplasmic microtubule organization; generation of neurons; internal protein amino acid acetylation; intracellular distribution of mitochondria; memory; microglial cell activation; microtubule cytoskeleton organization; microtubule polymerization; negative regulation of establishment of protein localization to mitochondrion; negative regulation of gene expression; negative regulation of kinase activity; negative regulation of mitochondrial fission; negative regulation of mitochondrial membrane potential; negative regulation of tubulin deacetylation; neurofibrillary tangle assembly; neuron projection development; plus-end-directed organelle transport along microtubule; positive regulation of axon extension; positive regulation of diacylglycerol kinase activity; positive regulation of microtubule polymerization; positive regulation of neuron death; positive regulation of protein localization; positive regulation of protein localization to synapse; positive regulation of superoxide anion generation; protein polymerization; regulation of autophagy; regulation of calcium-mediated signaling; regulation of cellular response to heat; regulation of chromosome organization; regulation of long-term synaptic depression; regulation of microtubule cytoskeleton organization; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of mitochondrial fission; regulation of response to DNA damage stimulus; regulation of synaptic plasticity; response to lead ion; rRNA metabolic process; stress granule assembly; supramolecular fiber organization; synapse organization","actin binding; apolipoprotein binding; chaperone binding; DNA binding; double-stranded DNA binding; dynactin binding; enzyme binding; histone-dependent DNA binding; Hsp90 protein binding; identical protein binding; lipoprotein particle binding; microtubule binding; microtubule lateral binding; minor groove of adenine-thymine-rich DNA binding; phosphatidylinositol binding; phosphatidylinositol bisphosphate binding; protein binding; protein kinase binding; protein phosphatase 2A binding; protein-macromolecule adaptor activity; RNA binding; sequence-specific DNA binding; SH3 domain binding; single-stranded DNA binding; tubulin binding","axolemma; axon; axon cytoplasm; cell body; cell projection; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; dendrite; dendritic spine; extracellular region; glial cell projection; growth cone; main axon; membrane; membrane raft; microtubule; microtubule cytoskeleton; mitochondrion; neurofibrillary tangle; neuron projection; neuronal cell body; nuclear periphery; nuclear speck; nucleus; plasma membrane; somatodendritic compartment; tubulin complex",null,"microtubule associated protein tau","http://www.ncbi.nlm.nih.gov/gene/?term=4137","4137","17762",null,null,null,"574327","P10636","P10637","A0A8I5YBN3","A0A8P0NFN5","A0A286ZJ75","P57786","GO:0030673; GO:0030424; GO:1904115; GO:0044297; GO:0042995; GO:0005737; GO:0036464; GO:0005856; GO:0005829; GO:0030425; GO:0043197; GO:0005576; GO:0097386; GO:0030426; GO:0044304; GO:0016020; GO:0045121; GO:0005874; GO:0015630; GO:0005739; GO:0097418; GO:0043005; GO:0043025; GO:0034399; GO:0016607; GO:0005634; GO:0005886; GO:0036477; GO:0045298","GO:0003779; GO:0034185; GO:0051087; GO:0003677; GO:0003690; GO:0034452; GO:0019899; GO:0099077; GO:0051879; GO:0042802; GO:0071813; GO:0008017; GO:0099609; GO:0003680; GO:0035091; GO:1902936; GO:0005515; GO:0019901; GO:0051721; GO:0030674; GO:0003723; GO:0043565; GO:0017124; GO:0003697; GO:0015631","GO:0006919; GO:1990000; GO:0048143; GO:0061564; GO:0098930; GO:0019896; GO:0007267; GO:1990416; GO:0034605; GO:1990090; GO:0034614; GO:0021954; GO:0031122; GO:0048699; GO:0006475; GO:0048312; GO:0007613; GO:0001774; GO:0000226; GO:0046785; GO:1903748; GO:0010629; GO:0033673; GO:0090258; GO:0010917; GO:1904428; GO:1902988; GO:0031175; GO:0072386; GO:0045773; GO:1905689; GO:0031116; GO:1901216; GO:1903829; GO:1902474; GO:0032930; GO:0051258; GO:0010506; GO:0050848; GO:1900034; GO:0033044; GO:1900452; GO:0070507; GO:0031113; GO:0031110; GO:0090140; GO:2001020; GO:0048167; GO:0010288; GO:0016072; GO:0034063; GO:0097435; GO:0050808","PTHR11501:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6893|UniProtKB=P10636"]
["Tau - phospho","Thr231","MAPT","150, 50, 25","rb",null,2,6,"n/a","n/a","n/a","n/a","# 2223",".ALZ., .APH., .APO., .CCP., .CD., .CP., .CSP., .DDR., .DI., .IMFR., .IMUR., .MAPK., .OP., .OPA., .OT., .OXS., .RTK., .SREME., .ST., .TRASR.",null,"MICROTUBULE-ASSOCIATED PROTEIN TAU","activation of cysteine-type endopeptidase activity involved in apoptotic process; amyloid fibril formation; astrocyte activation; axon development; axonal transport; axonal transport of mitochondrion; cell-cell signaling; cellular response to brain-derived neurotrophic factor stimulus; cellular response to heat; cellular response to nerve growth factor stimulus; cellular response to reactive oxygen species; central nervous system neuron development; cytoplasmic microtubule organization; generation of neurons; internal protein amino acid acetylation; intracellular distribution of mitochondria; memory; microglial cell activation; microtubule cytoskeleton organization; microtubule polymerization; negative regulation of establishment of protein localization to mitochondrion; negative regulation of gene expression; negative regulation of kinase activity; negative regulation of mitochondrial fission; negative regulation of mitochondrial membrane potential; negative regulation of tubulin deacetylation; neurofibrillary tangle assembly; neuron projection development; plus-end-directed organelle transport along microtubule; positive regulation of axon extension; positive regulation of diacylglycerol kinase activity; positive regulation of microtubule polymerization; positive regulation of neuron death; positive regulation of protein localization; positive regulation of protein localization to synapse; positive regulation of superoxide anion generation; protein polymerization; regulation of autophagy; regulation of calcium-mediated signaling; regulation of cellular response to heat; regulation of chromosome organization; regulation of long-term synaptic depression; regulation of microtubule cytoskeleton organization; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of mitochondrial fission; regulation of response to DNA damage stimulus; regulation of synaptic plasticity; response to lead ion; rRNA metabolic process; stress granule assembly; supramolecular fiber organization; synapse organization","actin binding; apolipoprotein binding; chaperone binding; DNA binding; double-stranded DNA binding; dynactin binding; enzyme binding; histone-dependent DNA binding; Hsp90 protein binding; identical protein binding; lipoprotein particle binding; microtubule binding; microtubule lateral binding; minor groove of adenine-thymine-rich DNA binding; phosphatidylinositol binding; phosphatidylinositol bisphosphate binding; protein binding; protein kinase binding; protein phosphatase 2A binding; protein-macromolecule adaptor activity; RNA binding; sequence-specific DNA binding; SH3 domain binding; single-stranded DNA binding; tubulin binding","axolemma; axon; axon cytoplasm; cell body; cell projection; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; dendrite; dendritic spine; extracellular region; glial cell projection; growth cone; main axon; membrane; membrane raft; microtubule; microtubule cytoskeleton; mitochondrion; neurofibrillary tangle; neuron projection; neuronal cell body; nuclear periphery; nuclear speck; nucleus; plasma membrane; somatodendritic compartment; tubulin complex",null,"microtubule associated protein tau","http://www.ncbi.nlm.nih.gov/gene/?term=4137","4137","17762",null,null,null,"574327","P10636","P10637","A0A8I5YBN3","A0A8P0NFN5","A0A286ZJ75","P57786","GO:0030673; GO:0030424; GO:1904115; GO:0044297; GO:0042995; GO:0005737; GO:0036464; GO:0005856; GO:0005829; GO:0030425; GO:0043197; GO:0005576; GO:0097386; GO:0030426; GO:0044304; GO:0016020; GO:0045121; GO:0005874; GO:0015630; GO:0005739; GO:0097418; GO:0043005; GO:0043025; GO:0034399; GO:0016607; GO:0005634; GO:0005886; GO:0036477; GO:0045298","GO:0003779; GO:0034185; GO:0051087; GO:0003677; GO:0003690; GO:0034452; GO:0019899; GO:0099077; GO:0051879; GO:0042802; GO:0071813; GO:0008017; GO:0099609; GO:0003680; GO:0035091; GO:1902936; GO:0005515; GO:0019901; GO:0051721; GO:0030674; GO:0003723; GO:0043565; GO:0017124; GO:0003697; GO:0015631","GO:0006919; GO:1990000; GO:0048143; GO:0061564; GO:0098930; GO:0019896; GO:0007267; GO:1990416; GO:0034605; GO:1990090; GO:0034614; GO:0021954; GO:0031122; GO:0048699; GO:0006475; GO:0048312; GO:0007613; GO:0001774; GO:0000226; GO:0046785; GO:1903748; GO:0010629; GO:0033673; GO:0090258; GO:0010917; GO:1904428; GO:1902988; GO:0031175; GO:0072386; GO:0045773; GO:1905689; GO:0031116; GO:1901216; GO:1903829; GO:1902474; GO:0032930; GO:0051258; GO:0010506; GO:0050848; GO:1900034; GO:0033044; GO:1900452; GO:0070507; GO:0031113; GO:0031110; GO:0090140; GO:2001020; GO:0048167; GO:0010288; GO:0016072; GO:0034063; GO:0097435; GO:0050808","PTHR11501:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6893|UniProtKB=P10636"]
["TAZ",null,"WWTR1","49","ms",null,1,1,6,6,8,8,"# 1626",".CCP., .CP., .CSP., .DEV., .HIPPO., .OP., .OPA., .OT., .ST., .TGFB., .TRASR., .UBI., .WNT.",null,"WW DOMAIN-CONTAINING TRANSCRIPTION REGULATOR PROTEIN 1","cilium assembly; glomerulus development; heart process; hippo signaling; kidney morphogenesis; mesenchymal cell differentiation; multicellular organism growth; negative regulation of canonical Wnt signaling pathway; negative regulation of fat cell differentiation; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of transcription by RNA polymerase II; osteoblast differentiation; positive regulation of cell population proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of osteoblast differentiation; positive regulation of protein localization to nucleus; positive regulation of transcription by RNA polymerase II; protein ubiquitination; regulation of canonical Wnt signaling pathway; regulation of DNA-templated transcription; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of SMAD protein signal transduction; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stem cell division; tissue homeostasis","protein binding; protein homodimerization activity; transcription coactivator activity; transcription corepressor activity","cytoplasm; cytosol; membrane; nuclear body; nucleoplasm; nucleus; plasma membrane; transcription regulator complex","Transcription factor","WW domain containing transcription regulator 1","http://www.ncbi.nlm.nih.gov/gene/?term=25937","25937","97064","295062","609743",null,null,"Q9GZV5","Q9EPK5","Q4V7E6","A0A8I3PQN6","F1SJP0","F6XXC8","GO:0005737; GO:0005829; GO:0016020; GO:0016604; GO:0005654; GO:0005634; GO:0005886; GO:0005667","GO:0005515; GO:0042803; GO:0003713; GO:0003714","GO:0060271; GO:0032835; GO:0003015; GO:0035329; GO:0060993; GO:0048762; GO:0035264; GO:0090090; GO:0045599; GO:0006469; GO:0001933; GO:0000122; GO:0001649; GO:0008284; GO:0010718; GO:0045669; GO:1900182; GO:0045944; GO:0016567; GO:0060828; GO:0006355; GO:0072307; GO:0060390; GO:0031146; GO:0017145; GO:0001894","PTHR17616:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24042|UniProtKB=Q9GZV5"]
["TAZ",null,"WWTR1","50","rb",null,2,2,"n/a","n/a","n/a","n/a","# 1861",".CCP., .CP., .CSP., .DEV., .HIPPO., .OP., .OPA., .OT., .ST., .TGFB., .TRASR., .UBI., .WNT.",null,"WW DOMAIN-CONTAINING TRANSCRIPTION REGULATOR PROTEIN 1","cilium assembly; glomerulus development; heart process; hippo signaling; kidney morphogenesis; mesenchymal cell differentiation; multicellular organism growth; negative regulation of canonical Wnt signaling pathway; negative regulation of fat cell differentiation; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of transcription by RNA polymerase II; osteoblast differentiation; positive regulation of cell population proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of osteoblast differentiation; positive regulation of protein localization to nucleus; positive regulation of transcription by RNA polymerase II; protein ubiquitination; regulation of canonical Wnt signaling pathway; regulation of DNA-templated transcription; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of SMAD protein signal transduction; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stem cell division; tissue homeostasis","protein binding; protein homodimerization activity; transcription coactivator activity; transcription corepressor activity","cytoplasm; cytosol; membrane; nuclear body; nucleoplasm; nucleus; plasma membrane; transcription regulator complex","Transcription factor","WW domain containing transcription regulator 1","http://www.ncbi.nlm.nih.gov/gene/?term=25937","25937","97064","295062","609743",null,null,"Q9GZV5","Q9EPK5","Q4V7E6","A0A8I3PQN6","F1SJP0","F6XXC8","GO:0005737; GO:0005829; GO:0016020; GO:0016604; GO:0005654; GO:0005634; GO:0005886; GO:0005667","GO:0005515; GO:0042803; GO:0003713; GO:0003714","GO:0060271; GO:0032835; GO:0003015; GO:0035329; GO:0060993; GO:0048762; GO:0035264; GO:0090090; GO:0045599; GO:0006469; GO:0001933; GO:0000122; GO:0001649; GO:0008284; GO:0010718; GO:0045669; GO:1900182; GO:0045944; GO:0016567; GO:0060828; GO:0006355; GO:0072307; GO:0060390; GO:0031146; GO:0017145; GO:0001894","PTHR17616:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=24042|UniProtKB=Q9GZV5"]
["TBK1 (NAK)",null,"TBK1","84","rb",null,2,1.1000000000000001,1,1,1,1,"# 1499",".APH., .CD., .CSP., .DI., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .NFKB., .OP., .OPA., .OT., .RAS., .RTK., .ST., .TOLL., .TRASR., .VIR.","Toll receptor signaling pathway","SERINE/THREONINE-PROTEIN KINASE TBK1","activation of innate immune response; defense response to Gram-positive bacterium; defense response to virus; dendritic cell proliferation; I-kappaB kinase/NF-kappaB signaling; immune system process; inflammatory response; innate immune response; negative regulation of gene expression; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of macroautophagy; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of type I interferon production; positive regulation of type I interferon-mediated signaling pathway; positive regulation of xenophagy; protein phosphorylation; regulation of gene expression; regulation of neuron death; regulation of type I interferon production; response to virus; type I interferon-mediated signaling pathway","ATP binding; identical protein binding; kinase activity; nucleic acid binding; nucleotide binding; phosphoprotein binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm; serine/threonine protein kinase complex","NFkB signaling","TANK binding kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=29110","29110","56480",null,null,null,"717427","Q9UHD2","Q9WUN2","A0A8I5ZSX1","A0A8I3N828",null,"F7DBZ3","GO:0005737; GO:0005829; GO:0043231; GO:0005654; GO:1902554","GO:0005524; GO:0042802; GO:0016301; GO:0003676; GO:0000166; GO:0051219; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0016740","GO:0002218; GO:0050830; GO:0051607; GO:0044565; GO:0007249; GO:0002376; GO:0006954; GO:0045087; GO:0010629; GO:0018105; GO:0018107; GO:0016310; GO:0043123; GO:0032727; GO:0032728; GO:0016239; GO:0033138; GO:0045944; GO:0032481; GO:0060340; GO:1904417; GO:0006468; GO:0010468; GO:1901214; GO:0032479; GO:0009615; GO:0060337","PTHR22969:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11584|UniProtKB=Q9UHD2","P00054"]
["TBK1 (NAK) - phospho","Ser172","TBK1","84","rb",null,2,1.1000000000000001,1,8,8,8,"# 1531",".APH., .CD., .CSP., .DI., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .NFKB., .OP., .OPA., .OT., .RAS., .RTK., .ST., .TOLL., .TRASR., .VIR.","Toll receptor signaling pathway","SERINE/THREONINE-PROTEIN KINASE TBK1","activation of innate immune response; defense response to Gram-positive bacterium; defense response to virus; dendritic cell proliferation; I-kappaB kinase/NF-kappaB signaling; immune system process; inflammatory response; innate immune response; negative regulation of gene expression; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of macroautophagy; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of type I interferon production; positive regulation of type I interferon-mediated signaling pathway; positive regulation of xenophagy; protein phosphorylation; regulation of gene expression; regulation of neuron death; regulation of type I interferon production; response to virus; type I interferon-mediated signaling pathway","ATP binding; identical protein binding; kinase activity; nucleic acid binding; nucleotide binding; phosphoprotein binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity","cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm; serine/threonine protein kinase complex","NFkB signaling","TANK binding kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=29110","29110","56480",null,null,null,"717427","Q9UHD2","Q9WUN2","A0A8I5ZSX1","A0A8I3N828",null,"F7DBZ3","GO:0005737; GO:0005829; GO:0043231; GO:0005654; GO:1902554","GO:0005524; GO:0042802; GO:0016301; GO:0003676; GO:0000166; GO:0051219; GO:0005515; GO:0004672; GO:0019903; GO:0106310; GO:0004674; GO:0016740","GO:0002218; GO:0050830; GO:0051607; GO:0044565; GO:0007249; GO:0002376; GO:0006954; GO:0045087; GO:0010629; GO:0018105; GO:0018107; GO:0016310; GO:0043123; GO:0032727; GO:0032728; GO:0016239; GO:0033138; GO:0045944; GO:0032481; GO:0060340; GO:1904417; GO:0006468; GO:0010468; GO:1901214; GO:0032479; GO:0009615; GO:0060337","PTHR22969:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11584|UniProtKB=Q9UHD2","P00054"]
["TBP (TF2D)",null,"TBP","38","rb",null,2,2,8,8,8,8,"# 1104",".CSP., .DI., .HUNT., .OP., .OPA., .OT., .ST., .TRASR.","Transcription regulation by bZIP transcription factor; General transcription by RNA polymerase I; Huntington disease","TATA-BOX-BINDING PROTEIN","DNA-templated transcription initiation; mRNA transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein phosphorylation; RNA polymerase II preinitiation complex assembly; transcription by RNA polymerase II; transcription by RNA polymerase III; transcription initiation at RNA polymerase II promoter","aryl hydrocarbon receptor binding; core promoter sequence-specific DNA binding; DNA binding; DNA-binding transcription factor binding; enzyme binding; general transcription initiation factor activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II general transcription initiation factor activity; RNA polymerase II general transcription initiation factor binding; RNA polymerase III general transcription initiation factor activity; RNA polymerase II-specific DNA-binding transcription factor binding; TFIIB-class transcription factor binding; transcription cis-regulatory region binding","chromatin; cytoplasm; euchromatin; female germ cell nucleus; female pronucleus; male germ cell nucleus; male pronucleus; nucleoplasm; nucleus; pronucleus; protein-containing complex; RNA polymerase transcription factor SL1 complex; transcription factor TFIIA complex; transcription factor TFIID complex; transcription preinitiation complex","Chromatin regulation / epigenetics","TATA-box binding protein","http://www.ncbi.nlm.nih.gov/gene/?term=6908","6908","21374",null,"611193",null,"696258","P20226","P29037","A0A8I5Y1F6","A0A8I3PUG8",null,"F6SEF6","GO:0000785; GO:0005737; GO:0000791; GO:0001674; GO:0001939; GO:0001673; GO:0001940; GO:0005654; GO:0005634; GO:0045120; GO:0032991; GO:0005668; GO:0005672; GO:0005669; GO:0097550","GO:0017162; GO:0001046; GO:0003677; GO:0140297; GO:0019899; GO:0140223; GO:0005515; GO:0000978; GO:0000979; GO:0016251; GO:0001091; GO:0000995; GO:0061629; GO:0001093; GO:0000976","GO:0006352; GO:0042789; GO:0060261; GO:0006468; GO:0051123; GO:0006366; GO:0006383; GO:0006367","PTHR10126:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11588|UniProtKB=P20226","P00055; P00022; P00029"]
["TCF1",null,"TCF7","50-28","rb",null,6.1,4,"n/a","n/a","n/a","n/a","# 1673",".ALZ., .AML., .ANG., .BRC., .CANCER., .CANPTHW., .CRC., .CSP., .DEV., .DI., .EMC., .HIPPO., .IMU., .IMUF., .IMUR., .OP., .OT., .PRC., .TCD., .TCR., .TMAT., .TRASR., .TYR., .WNT.","Gonadotropin releasing hormone receptor pathway; Alzheimer disease-presenilin pathway; Angiogenesis; Wnt signaling pathway","TRANSCRIPTION FACTOR 7","canonical Wnt signaling pathway; cellular response to interleukin-4; gamma-delta T cell differentiation; immune response; negative regulation of DNA-templated transcription; regulation of DNA-templated transcription; regulation of gamma-delta T cell differentiation; regulation of transcription by RNA polymerase II; Wnt signaling pathway","beta-catenin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding","beta-catenin-TCF complex; nuclear body; nucleoplasm; nucleus","Transcription factor","transcription factor 7","http://www.ncbi.nlm.nih.gov/gene/?term=6932","6932","21414",null,null,null,null,"P36402","Q00417","A0A8I5ZLY3","A0A8P0NU05","A0A286ZT50","A0A1D5QY59","GO:1990907; GO:0016604; GO:0005654; GO:0005634","GO:0008013; GO:0003677; GO:0000981; GO:0001217; GO:0005515; GO:0000978; GO:1990837; GO:0000976","GO:0060070; GO:0071353; GO:0042492; GO:0006955; GO:0045892; GO:0006355; GO:0045586; GO:0006357; GO:0016055","PTHR10373:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11639|UniProtKB=P36402","P06664; P00004; P00005; P00057"]
["TCF4",null,"TCF7L2","79, 58","rb",null,1,2,8,1,8,8,"# 3072",".ALZ., .AML., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .DEV., .DI., .EMC., .HIPPO., .OP., .OPA., .OT., .PI3K., .PRC., .RTK., .TRASR., .TYR., .WNT.","Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Angiogenesis; Wnt signaling pathway","TRANSCRIPTION FACTOR 7-LIKE 2","blood vessel development; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; fat cell differentiation; glucose homeostasis; maintenance of DNA repeat elements; myoblast fate commitment; negative regulation of canonical Wnt signaling pathway; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of type B pancreatic cell apoptotic process; pancreas development; positive regulation of epithelial cell proliferation; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of insulin secretion; positive regulation of protein binding; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of transcription by RNA polymerase II; regulation of hormone metabolic process; regulation of smooth muscle cell proliferation; regulation of transcription by RNA polymerase II; response to glucose; Wnt signaling pathway","armadillo repeat domain binding; beta-catenin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; gamma-catenin binding; molecular adaptor activity; nuclear receptor binding; nucleic acid binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding","beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; catenin-TCF7L2 complex; chromatin; nucleoplasm; nucleus; PML body; protein-DNA complex","Transcription factor","transcription factor 7 like 2","http://www.ncbi.nlm.nih.gov/gene/?term=6934","6934","21416",null,null,null,null,"Q9NQB0","Q924A0","A0A8I6A761","A0A8I3Q2C6","A0A286ZPN0","F6UWU3","GO:1990907; GO:0070369; GO:0071664; GO:0000785; GO:0005654; GO:0005634; GO:0016605; GO:0032993","GO:0070016; GO:0008013; GO:0003677; GO:0003700; GO:0000981; GO:0045295; GO:0060090; GO:0016922; GO:0003676; GO:0005515; GO:0019901; GO:0000978; GO:0061629; GO:0043565; GO:0000976","GO:0001568; GO:0060070; GO:0044334; GO:0045444; GO:0042593; GO:0043570; GO:0048625; GO:0090090; GO:0043433; GO:0045892; GO:2001237; GO:0000122; GO:2000675; GO:0031016; GO:0050679; GO:0010909; GO:0032024; GO:0032092; GO:0051897; GO:1900182; GO:0045944; GO:0032350; GO:0048660; GO:0006357; GO:0009749; GO:0016055","PTHR10373:SF32","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11641|UniProtKB=Q9NQB0","P00004; P00012; P00005; P00057"]
["TCF8 (ZEB1)",null,"ZEB1","200","rb",null,7,4,"n/a","n/a","n/a","n/a","# 1379",".CANCER., .CCP., .CP., .CSP., .DEV., .IMUF., .OP., .OT., .PRC., .TCD., .TCR., .TGFB., .TMAT., .TRASR.","Gonadotropin releasing hormone receptor pathway","ZINC FINGER E-BOX-BINDING HOMEOBOX 1","anatomical structure development; animal organ development; cartilage development; cell differentiation; cell population proliferation; cellular response to amino acid stimulus; cellular response to transforming growth factor beta stimulus; central nervous system development; cochlea morphogenesis; DNA-templated transcription; embryonic camera-type eye morphogenesis; embryonic morphogenesis; embryonic skeletal system morphogenesis; epithelial cell proliferation; forebrain development; keratinocyte proliferation; negative regulation of DNA-templated transcription; negative regulation of endothelial cell differentiation; negative regulation of epithelial cell differentiation; negative regulation of epithelial cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of transcription by RNA polymerase II; nervous system development; pattern specification process; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; regulation of mesenchymal cell proliferation; regulation of smooth muscle cell differentiation; regulation of T cell differentiation in thymus; regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; response to activity; response to nutrient levels; semicircular canal morphogenesis","chromatin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; E-box binding; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; zinc ion binding","chromatin; cytosol; nucleoplasm; nucleus","Transcription factor","zinc finger E-box binding homeobox 1","http://www.ncbi.nlm.nih.gov/gene/?term=6935","6935","21417","25705",null,null,null,"P37275","Q64318","Q62947","A0A8P0SYZ4","A0A287BLZ4","F7HFH3","GO:0000785; GO:0005829; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0003700; GO:0000981; GO:0001227; GO:0003690; GO:0070888; GO:0046872; GO:0005515; GO:0000978; GO:0043565; GO:0008270","GO:0048856; GO:0048513; GO:0051216; GO:0030154; GO:0008283; GO:0071230; GO:0071560; GO:0007417; GO:0090103; GO:0006351; GO:0048596; GO:0048598; GO:0048704; GO:0050673; GO:0030900; GO:0043616; GO:0045892; GO:0045602; GO:0030857; GO:0050680; GO:0010839; GO:0000122; GO:0007399; GO:0007389; GO:0045666; GO:0045944; GO:0010464; GO:0051150; GO:0033081; GO:0006357; GO:0017015; GO:0014823; GO:0031667; GO:0048752","PTHR24391:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11642|UniProtKB=P37275","P06664"]
["Telomerase reverse transcriptase (TERT)",null,"TERT","127","rb",null,1.1000000000000001,4,2,8,1,1,"# 1392",".ANG., .APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .DEV., .HIF., .OP., .OT., .OXS., .SREME., .TRASR., .WNT.",null,"TELOMERASE REVERSE TRANSCRIPTASE","cellular response to hypoxia; DNA biosynthetic process; DNA strand elongation; establishment of protein localization to telomere; mitochondrion organization; negative regulation of apoptotic process; negative regulation of cellular senescence; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of gene expression; negative regulation of miRNA maturation; negative regulation of neuron apoptotic process; positive regulation of angiogenesis; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of glucose import; positive regulation of hair cycle; positive regulation of miRNA transcription; positive regulation of nitric-oxide synthase activity; positive regulation of protein binding; positive regulation of protein localization to nucleolus; positive regulation of stem cell proliferation; positive regulation of transdifferentiation; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of Wnt signaling pathway; regulation of protein stability; replicative senescence; response to cadmium ion; RNA-templated DNA biosynthetic process; RNA-templated transcription; siRNA processing; siRNA transcription; telomere maintenance; telomere maintenance via telomerase","chaperone binding; DNA binding; identical protein binding; metal ion binding; nucleotidyltransferase activity; protein binding; protein C-terminus binding; protein homodimerization activity; protein N-terminus binding; RNA binding; RNA-dependent RNA polymerase activity; RNA-directed DNA polymerase activity; telomerase activity; telomerase RNA binding; telomerase RNA reverse transcriptase activity; telomeric DNA binding; template-free RNA nucleotidyltransferase; transcription coactivator binding; transferase activity; tRNA binding","chromosome; chromosome, telomeric region; cytoplasm; cytosol; mitochondrial nucleoid; mitochondrion; nuclear speck; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; plasma membrane; PML body; ribonucleoprotein complex; RNA-directed RNA polymerase complex; telomerase catalytic core complex; telomerase holoenzyme complex; TERT-RMRP complex","DNA replication regulation","telomerase reverse transcriptase","http://www.ncbi.nlm.nih.gov/gene/?term=7015","7015","21752","301965",null,null,null,"O14746","O70372","Q673L6","A0A8P0NCQ3","F1S027","F7GJ51","GO:0005694; GO:0000781; GO:0005737; GO:0005829; GO:0042645; GO:0005739; GO:0016607; GO:0000783; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0016605; GO:1990904; GO:0031379; GO:0000333; GO:0005697; GO:1990572","GO:0051087; GO:0003677; GO:0042802; GO:0046872; GO:0016779; GO:0005515; GO:0008022; GO:0042803; GO:0047485; GO:0003723; GO:0003968; GO:0003964; GO:0003720; GO:0070034; GO:0003721; GO:0042162; GO:0098680; GO:0001223; GO:0016740; GO:0000049","GO:0071456; GO:0071897; GO:0022616; GO:0070200; GO:0007005; GO:0043066; GO:2000773; GO:2000352; GO:2001240; GO:0010629; GO:1903799; GO:0043524; GO:0045766; GO:1900087; GO:0046326; GO:0042635; GO:1902895; GO:0051000; GO:0032092; GO:1904751; GO:2000648; GO:1903620; GO:1904754; GO:1904707; GO:0030177; GO:0031647; GO:0090399; GO:0046686; GO:0006278; GO:0001172; GO:0030422; GO:0140745; GO:0000723; GO:0007004","PTHR12066:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11730|UniProtKB=O14746"]
["TET1",null,"TET1","235","ms",null,4,4,"n/a","n/a","n/a","n/a","# 1698",".CCP., .CP., .CSP., .DEV., .MIG., .OP., .OT., .TGFB., .TRASR.",null,"METHYLCYTOSINE DIOXYGENASE TET1","5-methylcytosine catabolic process; cellular macromolecule metabolic process; chromatin organization; DNA demethylation; inner cell mass cell differentiation; macromolecule modification; negative regulation of cell migration; negative regulation of DNA methylation-dependent heterochromatin formation; negative regulation of stem cell population maintenance; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; nitrogen compound metabolic process; oxidative demethylation; positive regulation of cell population proliferation; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; primary metabolic process; protein O-linked glycosylation; stem cell population maintenance","dioxygenase activity; DNA binding; iron ion binding; metal ion binding; methyl-CpG binding; methylcytosine dioxygenase activity; oxidoreductase activity; zinc ion binding","chromosome; nucleus; Sin3 complex",null,"tet methylcytosine dioxygenase 1","http://www.ncbi.nlm.nih.gov/gene/?term=80312","80312",null,null,null,null,null,"Q8NFU7","Q3URK3","D4A4D3","A0A8P0PLS0",null,"A0A1D5QBU8","GO:0005694; GO:0005634; GO:0016580","GO:0051213; GO:0003677; GO:0005506; GO:0046872; GO:0008327; GO:0070579; GO:0016491; GO:0008270","GO:0006211; GO:0044260; GO:0006325; GO:0080111; GO:0001826; GO:0043412; GO:0030336; GO:0090310; GO:1902455; GO:0000122; GO:0030512; GO:0006807; GO:0070989; GO:0008284; GO:1902459; GO:0045944; GO:0044238; GO:0006493; GO:0019827","PTHR23358:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=29484|UniProtKB=Q8NFU7"]
["TFF1/pS2",null,"TFF1","13","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2390",".CCKR., .CCP., .CP., .CSP., .OP., .OPA., .ST.","CCKR signaling map","TREFOIL FACTOR 1","carbohydrate metabolic process; cell differentiation; cell population proliferation; maintenance of gastrointestinal epithelium; negative regulation of cell population proliferation; response to immobilization stress; response to iron ion; response to peptide hormone; signal transduction","growth factor activity; protein binding","extracellular region; extracellular space",null,"trefoil factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=7031","7031","21784","117270",null,null,null,"P04155","Q08423","Q63467","A0A8I3QY48",null,null,"GO:0005576; GO:0005615","GO:0008083; GO:0005515","GO:0005975; GO:0030154; GO:0008283; GO:0030277; GO:0008285; GO:0035902; GO:0010039; GO:0043434; GO:0007165","PTHR13826:SF18","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11755|UniProtKB=P04155","P06959"]
["TGF beta receptor I",null,"TGFBR1","56","rb",null,7,6,2,2,2.1,2.1,"# 1421",".ANG., .APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .FOXO., .HEPB., .HIPPO., .MAPK., .MIG., .OP., .OPA., .OT., .PAC., .PI3K., .RTK., .ST., .TCD., .TD., .TGFB., .TMAT., .TRASR., .UBI., .WNT.","TGF-beta signaling pathway; Wnt signaling pathway","TGF-BETA RECEPTOR TYPE-1","activin receptor signaling pathway; angiogenesis; angiogenesis involved in coronary vascular morphogenesis; anterior/posterior pattern specification; apoptotic process; artery morphogenesis; blastocyst development; cardiac epithelial to mesenchymal transition; cell differentiation; cell motility; cellular response to growth factor stimulus; cellular response to transforming growth factor beta stimulus; collagen fibril organization; coronary artery morphogenesis; embryonic cranial skeleton morphogenesis; endothelial cell activation; endothelial cell migration; endothelial cell proliferation; epicardium morphogenesis; epithelial to mesenchymal transition; extracellular structure organization; filopodium assembly; germ cell migration; heart development; in utero embryonic development; intracellular signal transduction; kidney development; lens development in camera-type eye; male gonad development; mesenchymal cell differentiation; negative regulation of apoptotic process; negative regulation of chondrocyte differentiation; negative regulation of endothelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; nervous system development; neuron fate commitment; parathyroid gland development; pathway-restricted SMAD protein phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pharyngeal system development; phosphorylation; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of endothelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of filopodium assembly; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of protein kinase B signaling; positive regulation of SMAD protein signal transduction; positive regulation of stress fiber assembly; positive regulation of tight junction disassembly; post-embryonic development; proepicardium development; protein phosphorylation; regulation of cardiac muscle cell proliferation; regulation of cell cycle; regulation of DNA-templated transcription; regulation of epithelial to mesenchymal transition; regulation of gene expression; regulation of macromolecule metabolic process; regulation of nitrogen compound metabolic process; regulation of primary metabolic process; regulation of protein binding; regulation of protein ubiquitination; response to cholesterol; roof of mouth development; signal transduction; skeletal system development; skeletal system morphogenesis; thymus development; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; ventricular compact myocardium morphogenesis; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis; wound healing","activin binding; activin receptor activity, type I; ATP binding; growth factor binding; ion binding; I-SMAD binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; signaling receptor binding; SMAD binding; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity; type II transforming growth factor beta receptor binding","activin receptor complex; anchoring junction; bicellular tight junction; cell surface; endosome; membrane; membrane raft; nucleus; plasma membrane; plasma membrane signaling receptor complex; receptor complex; transforming growth factor beta ligand-receptor complex","TGF-beta / Smad signaling","transforming growth factor beta receptor 1","http://www.ncbi.nlm.nih.gov/gene/?term=7046","7046","21812",null,null,null,null,"P36897","Q64729","A0A0H2UHE8","A0A7R7V602","A0A287BLR9","A0A1D5QUK7","GO:0048179; GO:0070161; GO:0005923; GO:0009986; GO:0005768; GO:0016020; GO:0045121; GO:0005634; GO:0005886; GO:0098802; GO:0043235; GO:0070021","GO:0048185; GO:0016361; GO:0005524; GO:0019838; GO:0043167; GO:0070411; GO:0016301; GO:0046872; GO:0000166; GO:0005515; GO:0004672; GO:0004674; GO:0005102; GO:0046332; GO:0016740; GO:0050431; GO:0005024; GO:0005025; GO:0004675; GO:0005114","GO:0032924; GO:0001525; GO:0060978; GO:0009952; GO:0006915; GO:0048844; GO:0001824; GO:0060317; GO:0030154; GO:0048870; GO:0071363; GO:0071560; GO:0030199; GO:0060982; GO:0048701; GO:0042118; GO:0043542; GO:0001935; GO:1905223; GO:0001837; GO:0043062; GO:0046847; GO:0008354; GO:0007507; GO:0001701; GO:0035556; GO:0001822; GO:0002088; GO:0008584; GO:0048762; GO:0043066; GO:0032331; GO:0001937; GO:2001237; GO:0007399; GO:0048663; GO:0060017; GO:0060389; GO:0018105; GO:0018107; GO:0060037; GO:0016310; GO:0043065; GO:2001235; GO:0030307; GO:0030335; GO:0008284; GO:0045893; GO:0001938; GO:0010718; GO:1905007; GO:0051491; GO:0010628; GO:0043410; GO:0010862; GO:0051897; GO:0060391; GO:0051496; GO:1905075; GO:0009791; GO:0003342; GO:0006468; GO:0060043; GO:0051726; GO:0006355; GO:0010717; GO:0010468; GO:0060255; GO:0051171; GO:0080090; GO:0043393; GO:0031396; GO:0070723; GO:0060021; GO:0007165; GO:0001501; GO:0048705; GO:0048538; GO:0007179; GO:0007178; GO:0003223; GO:0060412; GO:0003222; GO:0042060","PTHR23255:SF61","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11772|UniProtKB=P36897","P00052; P00057"]
["TGF beta receptor II",null,"TGFBR2","80-70","rb",null,6,7,"n/a","n/a","n/a","n/a","# 1502",".ANG., .APO., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CRC., .CSP., .DEV., .DI., .DRR., .FOXO., .HEPB., .HHSP., .HIF., .HIPPO., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PAC., .RTK., .SREME., .ST., .TCD., .TGFB., .TMAT., .TRASR.","TGF-beta signaling pathway","TGF-BETA RECEPTOR TYPE-2","activation of protein kinase activity; activin receptor signaling pathway; aging; animal organ morphogenesis; animal organ regeneration; aorta morphogenesis; aortic valve morphogenesis; apoptotic process; artery morphogenesis; atrioventricular valve morphogenesis; blood vessel development; brain development; branching involved in blood vessel morphogenesis; bronchus development; bronchus morphogenesis; cardiac left ventricle morphogenesis; cartilage development; cell differentiation; cell proliferation involved in endocardial cushion morphogenesis; cellular response to growth factor stimulus; common-partner SMAD protein phosphorylation; digestive tract development; embryo implantation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; endocardial cushion fusion; gastrulation; growth plate cartilage chondrocyte growth; growth plate cartilage development; heart development; heart looping; in utero embryonic development; inferior endocardial cushion morphogenesis; Langerhans cell differentiation; lens development in camera-type eye; lens fiber cell apoptotic process; lung development; lung lobe morphogenesis; lung morphogenesis; mammary gland morphogenesis; membranous septum morphogenesis; miRNA transport; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of cell population proliferation; Notch signaling pathway; outflow tract morphogenesis; outflow tract septum morphogenesis; pathway-restricted SMAD protein phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of cell population proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of reactive oxygen species metabolic process; positive regulation of skeletal muscle tissue regeneration; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein phosphorylation; receptor-mediated endocytosis; regulation of cell population proliferation; regulation of gene expression; regulation of macromolecule metabolic process; regulation of multicellular organismal process; regulation of nitrogen compound metabolic process; regulation of primary metabolic process; regulation of stem cell proliferation; response to cholesterol; response to estrogen; response to glucose; response to hypoxia; response to mechanical stimulus; response to nutrient; response to organic cyclic compound; response to organic substance; response to steroid hormone; response to xenobiotic stimulus; roof of mouth development; secondary palate development; smoothened signaling pathway; superior endocardial cushion morphogenesis; trachea formation; trachea morphogenesis; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; tricuspid valve morphogenesis; vasculogenesis; ventricular septum morphogenesis; wound healing","activin binding; activin receptor activity; ATP binding; glycosaminoglycan binding; kinase activity; metal ion binding; mitogen-activated protein kinase kinase kinase binding; molecular adaptor activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; signaling receptor activity; SMAD binding; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type II; transmembrane receptor protein serine/threonine kinase activity; type I transforming growth factor beta receptor binding","caveola; cell surface; cytoplasm; cytosol; external side of plasma membrane; extracellular region; membrane; membrane raft; plasma membrane; receptor complex; transforming growth factor beta ligand-receptor complex","TGF-beta / Smad signaling","transforming growth factor beta receptor 2","http://www.ncbi.nlm.nih.gov/gene/?term=7048","7048","21813","81810","477039",null,null,"P37173","Q62312","P38438","A0A8I3PL32","A0A5G2R694","F6Q193","GO:0005901; GO:0009986; GO:0005737; GO:0005829; GO:0009897; GO:0005576; GO:0016020; GO:0045121; GO:0005886; GO:0043235; GO:0070021","GO:0048185; GO:0017002; GO:0005524; GO:0005539; GO:0016301; GO:0046872; GO:0031435; GO:0060090; GO:0000166; GO:0005515; GO:0004672; GO:0004674; GO:0038023; GO:0046332; GO:0016740; GO:0050431; GO:0005024; GO:0005026; GO:0004675; GO:0034713","GO:0032147; GO:0032924; GO:0007568; GO:0009887; GO:0031100; GO:0035909; GO:0003180; GO:0006915; GO:0048844; GO:0003181; GO:0001568; GO:0007420; GO:0001569; GO:0060433; GO:0060434; GO:0003214; GO:0051216; GO:0030154; GO:1905315; GO:0071363; GO:0007182; GO:0048565; GO:0007566; GO:0048701; GO:0035162; GO:0003274; GO:0007369; GO:0003430; GO:0003417; GO:0007507; GO:0001947; GO:0001701; GO:1905317; GO:0061520; GO:0002088; GO:1990086; GO:0030324; GO:0060463; GO:0060425; GO:0060443; GO:0003149; GO:1990428; GO:0043011; GO:0060044; GO:0008285; GO:0007219; GO:0003151; GO:0003148; GO:0060389; GO:0018105; GO:0018107; GO:0016310; GO:0045766; GO:0002663; GO:2000563; GO:0008284; GO:0010634; GO:0010718; GO:1905007; GO:0002053; GO:0051138; GO:0010862; GO:2000379; GO:0043415; GO:0048661; GO:0002666; GO:0002651; GO:0006468; GO:0006898; GO:0042127; GO:0010468; GO:0060255; GO:0051239; GO:0051171; GO:0080090; GO:0072091; GO:0070723; GO:0043627; GO:0009749; GO:0001666; GO:0009612; GO:0007584; GO:0014070; GO:0010033; GO:0048545; GO:0009410; GO:0060021; GO:0062009; GO:0007224; GO:1905316; GO:0060440; GO:0060439; GO:0007179; GO:0007178; GO:0003186; GO:0001570; GO:0060412; GO:0042060","PTHR23255:SF55","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11773|UniProtKB=P37173","P00052"]
["Thymidin Phosphorylase (ECGF1)",null,"TYMP","50","rb",null,2,7,6,6,2,2,"# 0731",".ANG., .BLC., .CANCER., .CSP., .OP., .OPA., .ST.","Salvage pyrimidine deoxyribonucleotides; Pyrimidine Metabolism","THYMIDINE PHOSPHORYLASE","angiogenesis; cell differentiation; chemotaxis; dTMP catabolic process; mitochondrial genome maintenance; pyrimidine nucleobase metabolic process; pyrimidine nucleoside metabolic process; regulation of gastric motility; regulation of myelination; regulation of transmission of nerve impulse; signal transduction","1,4-alpha-oligoglucan phosphorylase activity; glycosyltransferase activity; growth factor activity; pentosyltransferase activity; protein binding; protein homodimerization activity; pyrimidine-nucleoside phosphorylase activity; thymidine phosphorylase activity; transferase activity","cytosol",null,"thymidine phosphorylase","http://www.ncbi.nlm.nih.gov/gene/?term=1890","1890","72962","315219",null,null,null,"P19971","Q99N42","Q5FVR2",null,null,null,"GO:0005829","GO:0004645; GO:0016757; GO:0008083; GO:0016763; GO:0005515; GO:0042803; GO:0016154; GO:0009032; GO:0016740","GO:0001525; GO:0030154; GO:0006935; GO:0046074; GO:0000002; GO:0006206; GO:0006213; GO:1905333; GO:0031641; GO:0051969; GO:0007165","PTHR10515:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=3148|UniProtKB=P19971","P02774; P02771"]
["Thymidylate synthase",null,"TYMS","35","ms",null,2,7,"n/a","n/a","n/a","n/a","# 0263",".DRR., .OP., .OT., .TRASR.","De novo pyrimidine deoxyribonucleotide biosynthesis; Formyltetrahydrofolate biosynthesis; Folate biosynthesis","THYMIDYLATE SYNTHASE","aging; cartilage development; circadian rhythm; developmental growth; DNA biosynthetic process; dTMP biosynthetic process; dTTP biosynthetic process; intestinal epithelial cell maturation; liver regeneration; methylation; negative regulation of translation; nucleotide biosynthetic process; pyrimidine nucleobase metabolic process; regulation of translation; response to cytokine; response to ethanol; response to folic acid; response to glucocorticoid; response to organic cyclic compound; response to organophosphorus; response to progesterone; response to toxic substance; response to vitamin A; response to xenobiotic stimulus; tetrahydrofolate interconversion; tetrahydrofolate metabolic process; uracil metabolic process","catalytic activity; folic acid binding; heterocyclic compound binding; methyltransferase activity; mRNA binding; mRNA regulatory element binding translation repressor activity; protein homodimerization activity; sequence-specific mRNA binding; thymidylate synthase activity; transferase activity; transferase activity, transferring one-carbon groups","cytoplasm; cytosol; membrane; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; nucleolus; nucleus","Nucleotide metabolism","thymidylate synthetase","http://www.ncbi.nlm.nih.gov/gene/?term=7298","7298","22171","29261",null,null,null,"P04818","P07607","P45352","A0A8I3MF02",null,"F6ZR77","GO:0005737; GO:0005829; GO:0016020; GO:0005743; GO:0005759; GO:0005739; GO:0005730; GO:0005634","GO:0003824; GO:0005542; GO:1901363; GO:0008168; GO:0003729; GO:0000900; GO:0042803; GO:1990825; GO:0004799; GO:0016740; GO:0016741","GO:0007568; GO:0051216; GO:0007623; GO:0048589; GO:0071897; GO:0006231; GO:0006235; GO:0060574; GO:0097421; GO:0032259; GO:0017148; GO:0009165; GO:0006206; GO:0006417; GO:0034097; GO:0045471; GO:0051593; GO:0051384; GO:0014070; GO:0046683; GO:0032570; GO:0009636; GO:0033189; GO:0009410; GO:0035999; GO:0046653; GO:0019860","PTHR11548:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12441|UniProtKB=P04818","P02739; P02743; P02742"]
["Thymidylate synthase",null,"TYMS","30","rb",null,7,7,"n/a","n/a","n/a","n/a","# 0695",".DRR., .OP., .OT., .TRASR.","De novo pyrimidine deoxyribonucleotide biosynthesis; Formyltetrahydrofolate biosynthesis; Folate biosynthesis","THYMIDYLATE SYNTHASE","aging; cartilage development; circadian rhythm; developmental growth; DNA biosynthetic process; dTMP biosynthetic process; dTTP biosynthetic process; intestinal epithelial cell maturation; liver regeneration; methylation; negative regulation of translation; nucleotide biosynthetic process; pyrimidine nucleobase metabolic process; regulation of translation; response to cytokine; response to ethanol; response to folic acid; response to glucocorticoid; response to organic cyclic compound; response to organophosphorus; response to progesterone; response to toxic substance; response to vitamin A; response to xenobiotic stimulus; tetrahydrofolate interconversion; tetrahydrofolate metabolic process; uracil metabolic process","catalytic activity; folic acid binding; heterocyclic compound binding; methyltransferase activity; mRNA binding; mRNA regulatory element binding translation repressor activity; protein homodimerization activity; sequence-specific mRNA binding; thymidylate synthase activity; transferase activity; transferase activity, transferring one-carbon groups","cytoplasm; cytosol; membrane; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; nucleolus; nucleus","Nucleotide metabolism","thymidylate synthetase","http://www.ncbi.nlm.nih.gov/gene/?term=7298","7298","22171","29261",null,null,null,"P04818","P07607","P45352","A0A8I3MF02",null,"F6ZR77","GO:0005737; GO:0005829; GO:0016020; GO:0005743; GO:0005759; GO:0005739; GO:0005730; GO:0005634","GO:0003824; GO:0005542; GO:1901363; GO:0008168; GO:0003729; GO:0000900; GO:0042803; GO:1990825; GO:0004799; GO:0016740; GO:0016741","GO:0007568; GO:0051216; GO:0007623; GO:0048589; GO:0071897; GO:0006231; GO:0006235; GO:0060574; GO:0097421; GO:0032259; GO:0017148; GO:0009165; GO:0006206; GO:0006417; GO:0034097; GO:0045471; GO:0051593; GO:0051384; GO:0014070; GO:0046683; GO:0032570; GO:0009636; GO:0033189; GO:0009410; GO:0035999; GO:0046653; GO:0019860","PTHR11548:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12441|UniProtKB=P04818","P02739; P02743; P02742"]
["Thyroid Transcription Factor 1",null,"NKX2-1","38, 36","rb",null,6,5,5,5,5,5,"# 1246",".CSP., .DEV., .MIG., .OP., .OT., .TGFB., .TRASR.",null,"HOMEOBOX PROTEIN NKX-2.1","anatomical structure formation involved in morphogenesis; animal organ morphogenesis; axon guidance; brain development; cell differentiation; cerebral cortex cell migration; cerebral cortex GABAergic interneuron differentiation; cerebral cortex neuron differentiation; club cell differentiation; developmental induction; endoderm development; epithelial tube branching involved in lung morphogenesis; forebrain development; forebrain dorsal/ventral pattern formation; forebrain neuron differentiation; forebrain neuron fate commitment; GABAergic neuron differentiation; gene expression; globus pallidus development; hippocampus development; hypothalamus development; interneuron migration; Leydig cell differentiation; locomotory behavior; lung development; lung saccule development; negative regulation of cell migration; negative regulation of DNA-templated transcription; negative regulation of epithelial to mesenchymal transition; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuron fate commitment; neuron migration; oligodendrocyte differentiation; pattern specification process; phospholipid metabolic process; pituitary gland development; positive regulation of circadian rhythm; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to hormone; rhythmic process; telencephalon cell migration; telencephalon development; thyroid gland development; type II pneumocyte differentiation","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; intronic transcription regulatory region sequence-specific DNA binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding","chromatin; nucleoplasm; nucleus; transcription regulator complex","Transcription factor","NK2 homeobox 1","http://www.ncbi.nlm.nih.gov/gene/?term=7080","7080","21869","25628",null,"100154384",null,"P43699","P50220","G3V740",null,"A0A287BE97","A0A5F7ZM60","GO:0000785; GO:0005654; GO:0005634; GO:0005667","GO:0003677; GO:0003700; GO:0000981; GO:0019899; GO:0001161; GO:0005515; GO:0000978; GO:0000977; GO:0061629; GO:0043565; GO:0000976","GO:0048646; GO:0009887; GO:0007411; GO:0007420; GO:0030154; GO:0021795; GO:0021892; GO:0021895; GO:0060486; GO:0031128; GO:0007492; GO:0060441; GO:0030900; GO:0021798; GO:0021879; GO:0021877; GO:0097154; GO:0010467; GO:0021759; GO:0021766; GO:0021854; GO:1904936; GO:0033327; GO:0007626; GO:0030324; GO:0060430; GO:0030336; GO:0045892; GO:0010719; GO:0000122; GO:0030512; GO:0048663; GO:0001764; GO:0048709; GO:0007389; GO:0006644; GO:0021983; GO:0042753; GO:0045893; GO:0010628; GO:0045944; GO:0006355; GO:0006357; GO:0009725; GO:0048511; GO:0022029; GO:0021537; GO:0030878; GO:0060510","PTHR24340:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11825|UniProtKB=P43699"]
["Thyroid Transcription Factor 1",null,"NKX2-1","42, 39","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2212",".CSP., .DEV., .MIG., .OP., .OT., .TGFB., .TRASR.",null,"HOMEOBOX PROTEIN NKX-2.1","anatomical structure formation involved in morphogenesis; animal organ morphogenesis; axon guidance; brain development; cell differentiation; cerebral cortex cell migration; cerebral cortex GABAergic interneuron differentiation; cerebral cortex neuron differentiation; club cell differentiation; developmental induction; endoderm development; epithelial tube branching involved in lung morphogenesis; forebrain development; forebrain dorsal/ventral pattern formation; forebrain neuron differentiation; forebrain neuron fate commitment; GABAergic neuron differentiation; gene expression; globus pallidus development; hippocampus development; hypothalamus development; interneuron migration; Leydig cell differentiation; locomotory behavior; lung development; lung saccule development; negative regulation of cell migration; negative regulation of DNA-templated transcription; negative regulation of epithelial to mesenchymal transition; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuron fate commitment; neuron migration; oligodendrocyte differentiation; pattern specification process; phospholipid metabolic process; pituitary gland development; positive regulation of circadian rhythm; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to hormone; rhythmic process; telencephalon cell migration; telencephalon development; thyroid gland development; type II pneumocyte differentiation","DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; intronic transcription regulatory region sequence-specific DNA binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding","chromatin; nucleoplasm; nucleus; transcription regulator complex","Transcription factor","NK2 homeobox 1","http://www.ncbi.nlm.nih.gov/gene/?term=7080","7080","21869","25628",null,"100154384",null,"P43699","P50220","G3V740",null,"A0A287BE97","A0A5F7ZM60","GO:0000785; GO:0005654; GO:0005634; GO:0005667","GO:0003677; GO:0003700; GO:0000981; GO:0019899; GO:0001161; GO:0005515; GO:0000978; GO:0000977; GO:0061629; GO:0043565; GO:0000976","GO:0048646; GO:0009887; GO:0007411; GO:0007420; GO:0030154; GO:0021795; GO:0021892; GO:0021895; GO:0060486; GO:0031128; GO:0007492; GO:0060441; GO:0030900; GO:0021798; GO:0021879; GO:0021877; GO:0097154; GO:0010467; GO:0021759; GO:0021766; GO:0021854; GO:1904936; GO:0033327; GO:0007626; GO:0030324; GO:0060430; GO:0030336; GO:0045892; GO:0010719; GO:0000122; GO:0030512; GO:0048663; GO:0001764; GO:0048709; GO:0007389; GO:0006644; GO:0021983; GO:0042753; GO:0045893; GO:0010628; GO:0045944; GO:0006355; GO:0006357; GO:0009725; GO:0048511; GO:0022029; GO:0021537; GO:0030878; GO:0060510","PTHR24340:SF33","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11825|UniProtKB=P43699"]
["TIAR",null,"TIAL1","42","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2857",".APO., .CCP., .CD., .CP., .CSP., .DEV., .HIPPO., .OP., .OPA., .OT., .ST., .TRASR.",null,"NUCLEOLYSIN TIAR","apoptotic process; defense response; germ cell development; negative regulation of cell population proliferation; positive regulation of hippo signaling; positive regulation of miRNA-mediated gene silencing; positive regulation of stem cell proliferation; regulation of transcription by RNA polymerase II; stem cell division; stem cell proliferation","DNA binding; mRNA 3'-UTR AU-rich region binding; mRNA 3'-UTR binding; nucleic acid binding; protein binding; protein-RNA adaptor activity; RNA binding","cytolytic granule; cytoplasm; cytoplasmic stress granule; lysosome; nucleoplasm; nucleus",null,"TIA1 cytotoxic granule associated RNA binding protein like 1","http://www.ncbi.nlm.nih.gov/gene/?term=7073","7073","21843",null,"477841",null,"703249","Q01085","P70318","A0A8I5ZND7","A0A8I3P582","F1SF34","F7BJ46","GO:0044194; GO:0005737; GO:0010494; GO:0005764; GO:0005654; GO:0005634","GO:0003677; GO:0035925; GO:0003730; GO:0003676; GO:0005515; GO:0140517; GO:0003723","GO:0006915; GO:0006952; GO:0007281; GO:0008285; GO:0035332; GO:2000637; GO:2000648; GO:0006357; GO:0017145; GO:0072089","PTHR10352:SF11","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11804|UniProtKB=Q01085"]
["TIGAR",null,"TIGAR","30","rb",null,6,2,2,1,2.1,2.1,"# 1230",".APH., .APO., .CAMET., .CANCER., .CD., .CSP., .DDR., .DREP., .DRR., .HIF., .OP., .OPA., .OT., .OXS., .SREME., .ST.","Cobalamin biosynthesis","FRUCTOSE-2,6-BISPHOSPHATASE TIGAR","apoptotic process; autophagy; cardiac muscle cell apoptotic process; cellular response to cobalt ion; cellular response to DNA damage stimulus; cellular response to hypoxia; fructose 1,6-bisphosphate metabolic process; fructose 2,6-bisphosphate metabolic process; glucose catabolic process to lactate via pyruvate; glycolytic process; intestinal epithelial cell development; mitophagy; negative regulation of glucose catabolic process to lactate via pyruvate; negative regulation of glycolytic process; negative regulation of mitophagy; negative regulation of neuron death; negative regulation of programmed cell death; negative regulation of reactive oxygen species metabolic process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of DNA repair; positive regulation of hexokinase activity; reactive oxygen species metabolic process; regulation of pentose-phosphate shunt; regulation of response to DNA damage checkpoint signaling; response to gamma radiation; response to ischemia; response to xenobiotic stimulus","bisphosphoglycerate 2-phosphatase activity; catalytic activity; fructose-2,6-bisphosphate 2-phosphatase activity; hydrolase activity; protein binding","cytoplasm; cytosol; mitochondrial outer membrane; mitochondrion; nucleus",null,"TP53 induced glycolysis regulatory phosphatase","http://www.ncbi.nlm.nih.gov/gene/?term=57103","57103","319801",null,null,"100154112",null,"Q9NQ88","Q8BZA9","A0A0G2K8S8","A0A8I3Q4T8","F1SKZ0",null,"GO:0005737; GO:0005829; GO:0005741; GO:0005739; GO:0005634","GO:0004083; GO:0003824; GO:0004331; GO:0016787; GO:0005515","GO:0006915; GO:0006914; GO:0010659; GO:0071279; GO:0006974; GO:0071456; GO:0030388; GO:0006003; GO:0019661; GO:0006096; GO:0060576; GO:0000423; GO:1904024; GO:0045820; GO:1901525; GO:1901215; GO:0043069; GO:2000378; GO:0010666; GO:0045739; GO:1903301; GO:0072593; GO:0043456; GO:1902153; GO:0010332; GO:0002931; GO:0009410","PTHR46517:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1185|UniProtKB=Q9NQ88","P02735"]
["TIMP-1",null,"TIMP1","30-28","rb",null,4,1,"n/a","n/a",8,8,"# 0252",".APO., .CCP., .CD., .CP., .CSP., .HIF., .INT., .MIG., .OP., .OPA., .OT., .SREME., .ST.",null,"METALLOPROTEINASE INHIBITOR 1","aging; cartilage development; cell activation; cellular response to UV-A; connective tissue replacement involved in inflammatory response wound healing; negative regulation of apoptotic process; negative regulation of catalytic activity; negative regulation of endopeptidase activity; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metallopeptidase activity; negative regulation of peptidase activity; negative regulation of trophoblast cell migration; positive regulation of cell population proliferation; regulation of integrin-mediated signaling pathway; response to cytokine; response to hormone; response to organic substance; response to peptide hormone; signal transduction; wound healing","cytokine activity; enzyme inhibitor activity; growth factor activity; metal ion binding; metalloendopeptidase inhibitor activity; peptidase inhibitor activity; protease binding; protein binding; zinc ion binding","basement membrane; endoplasmic reticulum lumen; extracellular exosome; extracellular matrix; extracellular region; extracellular space; platelet alpha granule lumen",null,"TIMP metallopeptidase inhibitor 1","http://www.ncbi.nlm.nih.gov/gene/?term=7076","7076","21857","116510",null,null,"574348","P01033","P12032","P30120","A0A8I3Q4H4","A0A5G2R0J4","Q95KL9","GO:0005604; GO:0005788; GO:0070062; GO:0031012; GO:0005576; GO:0005615; GO:0031093","GO:0005125; GO:0004857; GO:0008083; GO:0046872; GO:0008191; GO:0030414; GO:0002020; GO:0005515; GO:0008270","GO:0007568; GO:0051216; GO:0001775; GO:0071492; GO:0002248; GO:0043066; GO:0043086; GO:0010951; GO:0051045; GO:1905049; GO:0010466; GO:1901164; GO:0008284; GO:2001044; GO:0034097; GO:0009725; GO:0010033; GO:0043434; GO:0007165; GO:0042060","PTHR11844:SF20","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11820|UniProtKB=P01033"]
["TOPK (PBK)",null,"PBK","40","rb",null,1,4,7,7,5,8,"# 1527",".CCP., .CCY., .CSP., .IMFR., .IMUR., .MAPK., .OP., .OPA., .RTK., .ST.",null,"LYMPHOKINE-ACTIVATED KILLER T-CELL-ORIGINATED PROTEIN KINASE","cellular response to UV; mitotic cell cycle; negative regulation of inflammatory response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein phosphorylation; negative regulation of stress-activated MAPK cascade; p38MAPK cascade; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of mitotic DNA damage checkpoint; proteasome-mediated ubiquitin-dependent protein catabolic process; protein phosphorylation; stress-activated MAPK cascade","ATP binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","nucleus","Cell cycle control","PDZ binding kinase","http://www.ncbi.nlm.nih.gov/gene/?term=55872","55872","52033","290326","477371",null,"713242","Q96KB5","Q9JJ78","A1L1J7","A0A8I3NDE7","F1RJR9","F7FS18","GO:0005634","GO:0005524; GO:0004706; GO:0016301; GO:0004708; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0034644; GO:0000278; GO:0050728; GO:0032435; GO:0001933; GO:0032873; GO:0038066; GO:0018105; GO:0018108; GO:0016310; GO:1904291; GO:0043161; GO:0006468; GO:0051403","PTHR43289:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18282|UniProtKB=Q96KB5"]
["TOPK (PBK) - phospho","Thr9","PBK","40","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1526",".CCP., .CCY., .CSP., .IMFR., .IMUR., .MAPK., .OP., .OPA., .RTK., .ST.",null,"LYMPHOKINE-ACTIVATED KILLER T-CELL-ORIGINATED PROTEIN KINASE","cellular response to UV; mitotic cell cycle; negative regulation of inflammatory response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein phosphorylation; negative regulation of stress-activated MAPK cascade; p38MAPK cascade; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of mitotic DNA damage checkpoint; proteasome-mediated ubiquitin-dependent protein catabolic process; protein phosphorylation; stress-activated MAPK cascade","ATP binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity","nucleus","Cell cycle control","PDZ binding kinase","http://www.ncbi.nlm.nih.gov/gene/?term=55872","55872","52033","290326","477371",null,"713242","Q96KB5","Q9JJ78","A1L1J7","A0A8I3NDE7","F1RJR9","F7FS18","GO:0005634","GO:0005524; GO:0004706; GO:0016301; GO:0004708; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0004713; GO:0016740","GO:0034644; GO:0000278; GO:0050728; GO:0032435; GO:0001933; GO:0032873; GO:0038066; GO:0018105; GO:0018108; GO:0016310; GO:1904291; GO:0043161; GO:0006468; GO:0051403","PTHR43289:SF14","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18282|UniProtKB=Q96KB5"]
["Topo 2 alpha",null,"TOP2A","170","rb",null,2,7,5,5,5,5,"# 0892",".APO., .CCP., .CCY., .CD., .CP., .CSP., .DDR., .OP., .OT., .TRASR.","DNA replication","DNA TOPOISOMERASE 2-ALPHA","apoptotic chromosome condensation; cellular response to DNA damage stimulus; chromosome condensation; chromosome segregation; DNA ligation; DNA metabolic process; DNA topological change; embryonic cleavage; female meiotic nuclear division; hematopoietic progenitor cell differentiation; negative regulation of DNA duplex unwinding; positive regulation of apoptotic process; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; resolution of meiotic recombination intermediates; rhythmic process; sister chromatid segregation","ATP binding; ATP-dependent activity, acting on DNA; chromatin binding; DNA binding; DNA binding, bending; DNA topoisomerase activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; enzyme binding; histone deacetylase binding; isomerase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding; RNA binding; ubiquitin binding","centriole; chromosome, centromeric region; condensed chromosome; cytoplasm; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; male germ cell nucleus; nuclear chromosome; nucleolus; nucleoplasm; nucleus; protein-containing complex; ribonucleoprotein complex",null,"DNA topoisomerase II alpha","http://www.ncbi.nlm.nih.gov/gene/?term=7153","7153","21973",null,null,"396917","700707","P11388","Q01320","A0A0G2JUF8","A0A8I3MXG1","O46374","F7EVJ4","GO:0005814; GO:0000775; GO:0000793; GO:0005737; GO:0009330; GO:0001673; GO:0000228; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:1990904","GO:0005524; GO:0008094; GO:0003682; GO:0003677; GO:0008301; GO:0003916; GO:0003918; GO:0019899; GO:0042826; GO:0016853; GO:0000287; GO:0046872; GO:0000166; GO:0005515; GO:0008022; GO:0046982; GO:0042803; GO:0005080; GO:0003723; GO:0043130","GO:0030263; GO:0006974; GO:0030261; GO:0007059; GO:0006266; GO:0006259; GO:0006265; GO:0040016; GO:0007143; GO:0002244; GO:1905463; GO:0043065; GO:0045870; GO:0045944; GO:0042752; GO:0000712; GO:0048511; GO:0000819","PTHR10169:SF61","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11989|UniProtKB=P11388","P00017"]
["Topoisomerase 1",null,"TOP1","90","ms",null,4,4,"n/a","n/a","n/a","n/a","# 0462",".CCP., .CCY., .CP., .CSP., .DRR., .OP., .OPA., .OT., .ST., .TRASR.","DNA replication","DNA TOPOISOMERASE 1","chromatin remodeling; chromosome segregation; circadian regulation of gene expression; circadian rhythm; DNA replication; DNA topological change; embryonic cleavage; peptidyl-serine phosphorylation; phosphorylation; programmed cell death; response to xenobiotic stimulus; rhythmic process","ATP binding; chromatin binding; DNA binding; DNA binding, bending; DNA topoisomerase activity; DNA topoisomerase type I (single strand cut, ATP-independent) activity; double-stranded DNA binding; isomerase activity; protein binding; protein domain specific binding; protein serine/threonine kinase activity; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; single-stranded DNA binding; supercoiled DNA binding","chromosome; cytoplasm; fibrillar center; male germ cell nucleus; nuclear chromosome; nucleolus; nucleoplasm; nucleus; P-body; perikaryon; protein-DNA complex",null,"DNA topoisomerase I","http://www.ncbi.nlm.nih.gov/gene/?term=7150","7150","21969",null,"477229",null,"697300","P11387","Q04750","A0A0G2K3V7","A0A8P0SE48","A0A8W4F6H8","H9FZ51","GO:0005694; GO:0005737; GO:0001650; GO:0001673; GO:0000228; GO:0005730; GO:0005654; GO:0005634; GO:0000932; GO:0043204; GO:0032993","GO:0005524; GO:0003682; GO:0003677; GO:0008301; GO:0003916; GO:0003917; GO:0003690; GO:0016853; GO:0005515; GO:0019904; GO:0004674; GO:0003723; GO:0000978; GO:0003697; GO:0097100","GO:0006338; GO:0007059; GO:0032922; GO:0007623; GO:0006260; GO:0006265; GO:0040016; GO:0018105; GO:0016310; GO:0012501; GO:0009410; GO:0048511","PTHR10290:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11986|UniProtKB=P11387","P00017"]
["Topoisomerase 1",null,"TOP1","90","rb",null,2,7,7,6,2,2,"# 0724",".CCP., .CCY., .CP., .CSP., .DRR., .OP., .OPA., .OT., .ST., .TRASR.","DNA replication","DNA TOPOISOMERASE 1","chromatin remodeling; chromosome segregation; circadian regulation of gene expression; circadian rhythm; DNA replication; DNA topological change; embryonic cleavage; peptidyl-serine phosphorylation; phosphorylation; programmed cell death; response to xenobiotic stimulus; rhythmic process","ATP binding; chromatin binding; DNA binding; DNA binding, bending; DNA topoisomerase activity; DNA topoisomerase type I (single strand cut, ATP-independent) activity; double-stranded DNA binding; isomerase activity; protein binding; protein domain specific binding; protein serine/threonine kinase activity; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; single-stranded DNA binding; supercoiled DNA binding","chromosome; cytoplasm; fibrillar center; male germ cell nucleus; nuclear chromosome; nucleolus; nucleoplasm; nucleus; P-body; perikaryon; protein-DNA complex",null,"DNA topoisomerase I","http://www.ncbi.nlm.nih.gov/gene/?term=7150","7150","21969",null,"477229",null,"697300","P11387","Q04750","A0A0G2K3V7","A0A8P0SE48","A0A8W4F6H8","H9FZ51","GO:0005694; GO:0005737; GO:0001650; GO:0001673; GO:0000228; GO:0005730; GO:0005654; GO:0005634; GO:0000932; GO:0043204; GO:0032993","GO:0005524; GO:0003682; GO:0003677; GO:0008301; GO:0003916; GO:0003917; GO:0003690; GO:0016853; GO:0005515; GO:0019904; GO:0004674; GO:0003723; GO:0000978; GO:0003697; GO:0097100","GO:0006338; GO:0007059; GO:0032922; GO:0007623; GO:0006260; GO:0006265; GO:0040016; GO:0018105; GO:0016310; GO:0012501; GO:0009410; GO:0048511","PTHR10290:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11986|UniProtKB=P11387","P00017"]
["TRAP220 (PBP, MED1)",null,"MED1","168","gt",null,6,6,"n/a","n/a","n/a","n/a","# 1101",".ANG., .APO., .CANCER., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .IMUF., .INFG., .INFM., .OP., .OPA., .OT., .RTK., .ST., .TRASR.",null,"MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1","androgen biosynthetic process; angiogenesis; animal organ morphogenesis; animal organ regeneration; brain development; camera-type eye development; cell morphogenesis; cellular response to epidermal growth factor stimulus; cellular response to hepatocyte growth factor stimulus; cellular response to steroid hormone stimulus; cellular response to thyroid hormone stimulus; DNA-templated transcription; embryonic heart tube development; embryonic hemopoiesis; embryonic hindlimb morphogenesis; embryonic placenta development; enucleate erythrocyte development; epithelial cell proliferation involved in mammary gland duct elongation; erythrocyte development; fat cell differentiation; G0 to G1 transition; heart development; hematopoietic stem cell differentiation; in utero embryonic development; intracellular steroid hormone receptor signaling pathway; keratinocyte differentiation; lactation; lens development in camera-type eye; liver development; mammary gland branching involved in pregnancy; mammary gland branching involved in thelarche; mammary gland epithelial cell proliferation; megakaryocyte development; monocyte differentiation; mRNA transcription by RNA polymerase II; negative regulation of apoptotic process; negative regulation of keratinocyte proliferation; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; peroxisome proliferator activated receptor signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of erythrocyte differentiation; positive regulation of G0 to G1 transition; positive regulation of gene expression; positive regulation of hepatocyte proliferation; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; positive regulation of type II interferon-mediated signaling pathway; protein import into nucleus; regulation of DNA-templated transcription; regulation of RNA biosynthetic process; regulation of transcription by RNA polymerase II; regulation of vitamin D receptor signaling pathway; retinal pigment epithelium development; RNA polymerase II preinitiation complex assembly; thyroid hormone generation; thyroid hormone mediated signaling pathway; ventricular trabecula myocardium morphogenesis","chromatin binding; DNA binding; DNA-binding transcription factor binding; LBD domain binding; nuclear estrogen receptor binding; nuclear receptor binding; nuclear receptor coactivator activity; nuclear retinoic acid receptor binding; nuclear thyroid hormone receptor binding; nuclear vitamin D receptor binding; peroxisome proliferator activated receptor binding; promoter-specific chromatin binding; protein binding; protein-containing complex binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity; transcription coactivator binding; transcription coregulator activity; transcription corepressor activity","core mediator complex; mediator complex; membrane; nucleolus; nucleoplasm; nucleus","Transcription regulation","mediator complex subunit 1","http://www.ncbi.nlm.nih.gov/gene/?term=5469","5469","19014",null,null,null,null,"Q15648","Q925J9","A0A8I6A4N6","A0A8I3NEL7","A0A287B5Z6","A0A1D5QR31","GO:0070847; GO:0016592; GO:0016020; GO:0005730; GO:0005654; GO:0005634","GO:0003682; GO:0003677; GO:0140297; GO:0050693; GO:0030331; GO:0016922; GO:0030374; GO:0042974; GO:0046966; GO:0042809; GO:0042975; GO:1990841; GO:0005515; GO:0044877; GO:0061629; GO:0003713; GO:0001223; GO:0003712; GO:0003714","GO:0006702; GO:0001525; GO:0009887; GO:0031100; GO:0007420; GO:0043010; GO:0000902; GO:0071364; GO:0035729; GO:0071383; GO:0097067; GO:0006351; GO:0035050; GO:0035162; GO:0035116; GO:0001892; GO:0048822; GO:0060750; GO:0048821; GO:0045444; GO:0045023; GO:0007507; GO:0060218; GO:0001701; GO:0030518; GO:0030216; GO:0007595; GO:0002088; GO:0001889; GO:0060745; GO:0060744; GO:0033598; GO:0035855; GO:0030224; GO:0042789; GO:0043066; GO:0010839; GO:0045665; GO:0000122; GO:0035357; GO:0008284; GO:0045893; GO:0045648; GO:0070318; GO:0010628; GO:2000347; GO:0033148; GO:0045618; GO:0045944; GO:0032968; GO:0060261; GO:0060335; GO:0006606; GO:0006355; GO:2001141; GO:0006357; GO:0070562; GO:0003406; GO:0051123; GO:0006590; GO:0002154; GO:0003222","PTHR12881:SF10","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=9234|UniProtKB=Q15648"]
["Trk B",null,"NTRK2","145-116, 95-70","ms",null,4,7,"n/a","n/a","n/a","n/a","# 0528",".APO., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DRAS., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR.",null,"BDNF/NT-3 GROWTH FACTORS RECEPTOR","brain-derived neurotrophic factor receptor signaling pathway; cell differentiation; cellular response to amino acid stimulus; cellular response to brain-derived neurotrophic factor stimulus; cellular response to nerve growth factor stimulus; cellular response to stimulus; central nervous system neuron development; cerebral cortex development; circadian rhythm; feeding behavior; glutamate secretion; learning; long-term synaptic potentiation; mechanoreceptor differentiation; myelination in peripheral nervous system; negative regulation of amyloid-beta formation; negative regulation of anoikis; negative regulation of neuron apoptotic process; nervous system development; neuron differentiation; neuron migration; neuronal action potential propagation; neurotrophin signaling pathway; oligodendrocyte differentiation; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; peripheral nervous system neuron development; phosphorylation; positive regulation of axonogenesis; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of MAPK cascade; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein phosphorylation; positive regulation of synapse assembly; protein autophosphorylation; protein phosphorylation; regulation of GTPase activity; regulation of metabolic process; regulation of protein kinase B signaling; retina development in camera-type eye; retinal rod cell development; transmembrane receptor protein tyrosine kinase signaling pathway; trans-synaptic signaling by BDNF, modulating synaptic transmission; trans-synaptic signaling by neuropeptide, modulating synaptic transmission; vasculogenesis","ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor receptor activity; kinase activity; neurotrophin binding; neurotrophin receptor activity; nucleotide binding; protease binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity","axon; axon terminus; cell projection; cytoplasm; cytosol; dendrite; dendritic spine; early endosome; early endosome membrane; endosome; endosome membrane; membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; receptor complex; synapse; terminal bouton","Neuronal development","neurotrophic receptor tyrosine kinase 2","http://www.ncbi.nlm.nih.gov/gene/?term=4915","4915","18212","25054","484147",null,"709757","Q16620","P15209","Q63604","A0A8I3MNY6","A0A287A6X2","A0A5F7Z783","GO:0030424; GO:0043679; GO:0042995; GO:0005737; GO:0005829; GO:0030425; GO:0043197; GO:0005769; GO:0031901; GO:0005768; GO:0010008; GO:0016020; GO:0048471; GO:0005886; GO:0014069; GO:0043235; GO:0045202; GO:0043195","GO:0005524; GO:0048403; GO:0060175; GO:0016301; GO:0043121; GO:0005030; GO:0000166; GO:0002020; GO:0005515; GO:0042803; GO:0004672; GO:0004713; GO:0016740; GO:0004714","GO:0031547; GO:0030154; GO:0071230; GO:1990416; GO:1990090; GO:0051716; GO:0021954; GO:0021987; GO:0007623; GO:0007631; GO:0014047; GO:0007612; GO:0060291; GO:0042490; GO:0022011; GO:1902430; GO:2000811; GO:0043524; GO:0007399; GO:0030182; GO:0001764; GO:0019227; GO:0038179; GO:0048709; GO:0018105; GO:0018108; GO:0048935; GO:0016310; GO:0050772; GO:0008284; GO:0070374; GO:0010628; GO:0033674; GO:0043410; GO:0010976; GO:0033138; GO:0014068; GO:0001934; GO:0051965; GO:0046777; GO:0006468; GO:0043087; GO:0019222; GO:0051896; GO:0060041; GO:0046548; GO:0007169; GO:0099183; GO:0099551; GO:0001570","PTHR24416:SF136","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8032|UniProtKB=Q16620"]
["TRPC6",null,"TRPC6","110","rb",null,1,4,"n/a","n/a","n/a","n/a","# 2114",".ALZ., .DI., .OP.","Alzheimer disease-presenilin pathway","SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6","calcium ion transmembrane transport; calcium ion transport; cation transport; ion transport; positive regulation of calcium ion transport; positive regulation of cytosolic calcium ion concentration; positive regulation of ion transmembrane transporter activity; regulation of cytosolic calcium ion concentration; single fertilization; transmembrane transport","calcium channel activity; cation channel activity; inositol 1,4,5 trisphosphate binding; ion channel activity; protein binding; protein homodimerization activity; store-operated calcium channel activity","cation channel complex; cytoplasm; membrane; plasma membrane; slit diaphragm",null,"transient receptor potential cation channel subfamily C member 6","http://www.ncbi.nlm.nih.gov/gene/?term=7225","7225","22068",null,null,null,null,"Q9Y210","Q61143","F7EUD8","A0A8P0SJE8","A0A5G2RN01","A0A1D5QN47","GO:0034703; GO:0005737; GO:0016020; GO:0005886; GO:0036057","GO:0005262; GO:0005261; GO:0070679; GO:0005216; GO:0005515; GO:0042803; GO:0015279","GO:0070588; GO:0006816; GO:0006812; GO:0006811; GO:0051928; GO:0007204; GO:0032414; GO:0051480; GO:0007338; GO:0055085","PTHR10117:SF7","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12338|UniProtKB=Q9Y210","P00004"]
["TSC1 (Hamartin)",null,"TSC1","170-150","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2146",".AMPK., .APH., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .DRAS., .IMU., .IMUF., .IMUR., .INS., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .SREME., .ST., .TCR., .TRASR.","p53 pathway by glucose deprivation; Insulin/IGF pathway-protein kinase B signaling cascade","HAMARTIN","activation of GTPase activity; adaptive immune response; adult locomotory behavior; associative learning; cardiac muscle cell differentiation; cell population proliferation; cell projection organization; cell-matrix adhesion; cellular response to oxygen-glucose deprivation; cerebral cortex development; glucose import; hippocampus development; kidney development; memory T cell differentiation; myelination; negative regulation of ATP-dependent activity; negative regulation of cell population proliferation; negative regulation of cell size; negative regulation of GTPase activity; negative regulation of macroautophagy; negative regulation of neuron projection development; negative regulation of oxidative stress-induced neuron death; negative regulation of TOR signaling; negative regulation of translation; nervous system development; neural tube closure; positive regulation of focal adhesion assembly; positive regulation of macroautophagy; positive regulation of stress fiber assembly; potassium ion transport; protein stabilization; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of focal adhesion assembly; regulation of neuron death; regulation of phosphoprotein phosphatase activity; regulation of protein kinase activity; regulation of stress fiber assembly; regulation of translation; response to insulin; response to nutrient levels; response to peptide; rRNA export from nucleus; synapse organization","ATPase inhibitor activity; chaperone binding; GTPase activating protein binding; Hsp70 protein binding; Hsp90 protein binding; protein binding; protein N-terminus binding; protein-containing complex binding","actin filament; cell cortex; cell projection; chaperone complex; cytoplasm; cytoskeleton; cytosol; growth cone; intracellular membrane-bounded organelle; lamellipodium; lipid droplet; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein-containing complex; TSC1-TSC2 complex",null,"TSC complex subunit 1","http://www.ncbi.nlm.nih.gov/gene/?term=7248","7248","64930",null,null,null,null,"Q92574","Q9EP53","A0A8L2Q989","A0A8I3NUE2",null,"A0A1D5Q848","GO:0005884; GO:0005938; GO:0042995; GO:0101031; GO:0005737; GO:0005856; GO:0005829; GO:0030426; GO:0043231; GO:0030027; GO:0005811; GO:0016020; GO:0005634; GO:0048471; GO:0005886; GO:0014069; GO:0032991; GO:0033596","GO:0042030; GO:0051087; GO:0032794; GO:0030544; GO:0051879; GO:0005515; GO:0047485; GO:0044877","GO:0090630; GO:0002250; GO:0008344; GO:0008306; GO:0055007; GO:0008283; GO:0030030; GO:0007160; GO:0090650; GO:0021987; GO:0046323; GO:0021766; GO:0001822; GO:0043379; GO:0042552; GO:0032780; GO:0008285; GO:0045792; GO:0034260; GO:0016242; GO:0010977; GO:1903204; GO:0032007; GO:0017148; GO:0007399; GO:0001843; GO:0051894; GO:0016239; GO:0051496; GO:0006813; GO:0050821; GO:0051726; GO:0001952; GO:0051893; GO:1901214; GO:0043666; GO:0045859; GO:0051492; GO:0006417; GO:0032868; GO:0031667; GO:1901652; GO:0006407; GO:0050808","PTHR15154:SF2","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12362|UniProtKB=Q92574","P04397; P00033"]
["TSC2 (Tuberin)",null,"TSC2","200","rb",null,2,1,"n/a","n/a","n/a","n/a","# 2144",".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","p53 pathway by glucose deprivation; Insulin/IGF pathway-protein kinase B signaling cascade","TUBERIN","anoikis; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of mitophagy; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of TOR signaling; negative regulation of Wnt signaling pathway; neural tube closure; positive chemotaxis; positive regulation of GTPase activity; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; vesicle-mediated transport","GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding","cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; TSC1-TSC2 complex",null,"TSC complex subunit 2","http://www.ncbi.nlm.nih.gov/gene/?term=7249","7249",null,"24855",null,null,null,"P49815","A0A2I3BPE9","A0A0G2JSL4","A0A8P0NKR5","A0A287ADS4","A0A1D5QB26","GO:0005737; GO:0005829; GO:0005794; GO:0005764; GO:0016020; GO:0005634; GO:0048471; GO:0014069; GO:0033596","GO:0005096; GO:0051879; GO:0019902; GO:0005515; GO:0042803; GO:0031267","GO:0043276; GO:0006897; GO:0007507; GO:0048009; GO:0008285; GO:0046627; GO:1901525; GO:0014067; GO:0006469; GO:0051898; GO:0032007; GO:0030178; GO:0001843; GO:0050918; GO:0043547; GO:0016239; GO:0006606; GO:0043491; GO:0008104; GO:0051726; GO:0030100; GO:0046626; GO:0051056; GO:0016192","PTHR10063:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12363|UniProtKB=P49815","P04397; P00033"]
["TSC2 (Tuberin) - phospho","Ser1254","TSC2","200","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2393",".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","p53 pathway by glucose deprivation; Insulin/IGF pathway-protein kinase B signaling cascade","TUBERIN","anoikis; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of mitophagy; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of TOR signaling; negative regulation of Wnt signaling pathway; neural tube closure; positive chemotaxis; positive regulation of GTPase activity; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; vesicle-mediated transport","GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding","cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; TSC1-TSC2 complex",null,"TSC complex subunit 2","http://www.ncbi.nlm.nih.gov/gene/?term=7249","7249",null,"24855",null,null,null,"P49815","A0A2I3BPE9","A0A0G2JSL4","A0A8P0NKR5","A0A287ADS4","A0A1D5QB26","GO:0005737; GO:0005829; GO:0005794; GO:0005764; GO:0016020; GO:0005634; GO:0048471; GO:0014069; GO:0033596","GO:0005096; GO:0051879; GO:0019902; GO:0005515; GO:0042803; GO:0031267","GO:0043276; GO:0006897; GO:0007507; GO:0048009; GO:0008285; GO:0046627; GO:1901525; GO:0014067; GO:0006469; GO:0051898; GO:0032007; GO:0030178; GO:0001843; GO:0050918; GO:0043547; GO:0016239; GO:0006606; GO:0043491; GO:0008104; GO:0051726; GO:0030100; GO:0046626; GO:0051056; GO:0016192","PTHR10063:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12363|UniProtKB=P49815","P04397; P00033"]
["TSC2 (Tuberin) - phospho","Ser1387","TSC2","200","rb",null,2,1,"n/a","n/a","n/a","n/a","# 2394",".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","p53 pathway by glucose deprivation; Insulin/IGF pathway-protein kinase B signaling cascade","TUBERIN","anoikis; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of mitophagy; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of TOR signaling; negative regulation of Wnt signaling pathway; neural tube closure; positive chemotaxis; positive regulation of GTPase activity; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; vesicle-mediated transport","GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding","cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; TSC1-TSC2 complex",null,"TSC complex subunit 2","http://www.ncbi.nlm.nih.gov/gene/?term=7249","7249",null,"24855",null,null,null,"P49815","A0A2I3BPE9","A0A0G2JSL4","A0A8P0NKR5","A0A287ADS4","A0A1D5QB26","GO:0005737; GO:0005829; GO:0005794; GO:0005764; GO:0016020; GO:0005634; GO:0048471; GO:0014069; GO:0033596","GO:0005096; GO:0051879; GO:0019902; GO:0005515; GO:0042803; GO:0031267","GO:0043276; GO:0006897; GO:0007507; GO:0048009; GO:0008285; GO:0046627; GO:1901525; GO:0014067; GO:0006469; GO:0051898; GO:0032007; GO:0030178; GO:0001843; GO:0050918; GO:0043547; GO:0016239; GO:0006606; GO:0043491; GO:0008104; GO:0051726; GO:0030100; GO:0046626; GO:0051056; GO:0016192","PTHR10063:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12363|UniProtKB=P49815","P04397; P00033"]
["TSC2 (Tuberin) - phospho","Ser664","TSC2","200","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2395",".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","p53 pathway by glucose deprivation; Insulin/IGF pathway-protein kinase B signaling cascade","TUBERIN","anoikis; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of mitophagy; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of TOR signaling; negative regulation of Wnt signaling pathway; neural tube closure; positive chemotaxis; positive regulation of GTPase activity; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; vesicle-mediated transport","GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding","cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; TSC1-TSC2 complex",null,"TSC complex subunit 2","http://www.ncbi.nlm.nih.gov/gene/?term=7249","7249",null,"24855",null,null,null,"P49815","A0A2I3BPE9","A0A0G2JSL4","A0A8P0NKR5","A0A287ADS4","A0A1D5QB26","GO:0005737; GO:0005829; GO:0005794; GO:0005764; GO:0016020; GO:0005634; GO:0048471; GO:0014069; GO:0033596","GO:0005096; GO:0051879; GO:0019902; GO:0005515; GO:0042803; GO:0031267","GO:0043276; GO:0006897; GO:0007507; GO:0048009; GO:0008285; GO:0046627; GO:1901525; GO:0014067; GO:0006469; GO:0051898; GO:0032007; GO:0030178; GO:0001843; GO:0050918; GO:0043547; GO:0016239; GO:0006606; GO:0043491; GO:0008104; GO:0051726; GO:0030100; GO:0046626; GO:0051056; GO:0016192","PTHR10063:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12363|UniProtKB=P49815","P04397; P00033"]
["TSC2 (Tuberin) - phospho","Ser939","TSC2","200","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2496",".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","p53 pathway by glucose deprivation; Insulin/IGF pathway-protein kinase B signaling cascade","TUBERIN","anoikis; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of mitophagy; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of TOR signaling; negative regulation of Wnt signaling pathway; neural tube closure; positive chemotaxis; positive regulation of GTPase activity; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; vesicle-mediated transport","GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding","cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; TSC1-TSC2 complex",null,"TSC complex subunit 2","http://www.ncbi.nlm.nih.gov/gene/?term=7249","7249",null,"24855",null,null,null,"P49815","A0A2I3BPE9","A0A0G2JSL4","A0A8P0NKR5","A0A287ADS4","A0A1D5QB26","GO:0005737; GO:0005829; GO:0005794; GO:0005764; GO:0016020; GO:0005634; GO:0048471; GO:0014069; GO:0033596","GO:0005096; GO:0051879; GO:0019902; GO:0005515; GO:0042803; GO:0031267","GO:0043276; GO:0006897; GO:0007507; GO:0048009; GO:0008285; GO:0046627; GO:1901525; GO:0014067; GO:0006469; GO:0051898; GO:0032007; GO:0030178; GO:0001843; GO:0050918; GO:0043547; GO:0016239; GO:0006606; GO:0043491; GO:0008104; GO:0051726; GO:0030100; GO:0046626; GO:0051056; GO:0016192","PTHR10063:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12363|UniProtKB=P49815","P04397; P00033"]
["TSC2 (Tuberin) - phospho","Tyr1571","TSC2","200","rb",null,4,2,"n/a","n/a","n/a","n/a","# 2391",".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","p53 pathway by glucose deprivation; Insulin/IGF pathway-protein kinase B signaling cascade","TUBERIN","anoikis; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of mitophagy; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling; negative regulation of TOR signaling; negative regulation of Wnt signaling pathway; neural tube closure; positive chemotaxis; positive regulation of GTPase activity; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; vesicle-mediated transport","GTPase activator activity; Hsp90 protein binding; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding","cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; TSC1-TSC2 complex",null,"TSC complex subunit 2","http://www.ncbi.nlm.nih.gov/gene/?term=7249","7249",null,"24855",null,null,null,"P49815","A0A2I3BPE9","A0A0G2JSL4","A0A8P0NKR5","A0A287ADS4","A0A1D5QB26","GO:0005737; GO:0005829; GO:0005794; GO:0005764; GO:0016020; GO:0005634; GO:0048471; GO:0014069; GO:0033596","GO:0005096; GO:0051879; GO:0019902; GO:0005515; GO:0042803; GO:0031267","GO:0043276; GO:0006897; GO:0007507; GO:0048009; GO:0008285; GO:0046627; GO:1901525; GO:0014067; GO:0006469; GO:0051898; GO:0032007; GO:0030178; GO:0001843; GO:0050918; GO:0043547; GO:0016239; GO:0006606; GO:0043491; GO:0008104; GO:0051726; GO:0030100; GO:0046626; GO:0051056; GO:0016192","PTHR10063:SF0","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12363|UniProtKB=P49815","P04397; P00033"]
["TSG101",null,"TSG101","45","rb",null,1,2,"n/a","n/a","n/a","n/a","# 1974",".APH., .CCP., .CCY., .CD., .CP., .CSP., .EGFR., .ErbB., .IMUR., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .UBI., .VIR.",null,"TUMOR SUSCEPTIBILITY GENE 101 PROTEIN","autophagosome maturation; cell cycle; cell differentiation; cell division; endosome to lysosome transport; exosomal secretion; extracellular transport; keratinocyte differentiation; macroautophagy; membrane fission; membrane organization; multivesicular body assembly; negative regulation of cell population proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; positive regulation of viral budding via host ESCRT complex; protein modification process; protein monoubiquitination; protein transport; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; regulation of cell cycle; regulation of cell growth; regulation of extracellular exosome assembly; regulation of MAP kinase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; viral budding; viral budding via host ESCRT complex; viral release from host cell","calcium-dependent protein binding; DNA binding; nuclear receptor coactivator activity; protein binding; protein homodimerization activity; protein-containing complex binding; transcription corepressor activity; ubiquitin binding; ubiquitin protein ligase binding; virion binding","cytoplasm; cytoskeleton; cytosol; early endosome; early endosome membrane; endosome; endosome membrane; ESCRT I complex; extracellular exosome; Flemming body; late endosome; late endosome membrane; membrane; microtubule organizing center; multivesicular body; nucleolus; nucleus; plasma membrane",null,"tumor susceptibility 101","http://www.ncbi.nlm.nih.gov/gene/?term=7251","7251","22088","292925","485406",null,null,"Q99816","Q61187","Q6IRE4","A0A8I3P8P4",null,"A0A1D5RJI3","GO:0005737; GO:0005856; GO:0005829; GO:0005769; GO:0031901; GO:0005768; GO:0010008; GO:0000813; GO:0070062; GO:0090543; GO:0005770; GO:0031902; GO:0016020; GO:0005815; GO:0005771; GO:0005730; GO:0005634; GO:0005886","GO:0048306; GO:0003677; GO:0030374; GO:0005515; GO:0042803; GO:0044877; GO:0003714; GO:0043130; GO:0031625; GO:0046790","GO:0097352; GO:0007049; GO:0030154; GO:0051301; GO:0008333; GO:1990182; GO:0006858; GO:0030216; GO:0016236; GO:0090148; GO:0061024; GO:0036258; GO:0008285; GO:0042059; GO:0007175; GO:0000122; GO:0045893; GO:1903543; GO:2000397; GO:1903774; GO:0036211; GO:0006513; GO:0015031; GO:0043328; GO:0051726; GO:0001558; GO:1903551; GO:0043405; GO:0043162; GO:0046755; GO:0039702; GO:0019076","PTHR23306:SF17","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=15971|UniProtKB=Q99816"]
["TSP-1 (Thrombospondin-1)",null,"THBS1","190","ms",null,7,4,"n/a","n/a","n/a","n/a","# 0529",".ANG., .APO., .BLC., .CANCER., .CCP., .CD., .CP., .CSP., .DEV., .DRR., .FGFR., .HIF., .IMFR., .IMU., .IMUR., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .PLAT., .RTK., .SREME., .ST., .TGFB., .TNF., .TRASR.","p53 pathway","THROMBOSPONDIN-1","behavioral response to pain; cell adhesion; cell migration; cellular response to growth factor stimulus; cellular response to heat; cellular response to tumor necrosis factor; chronic inflammatory response; engulfment of apoptotic cell; immune response; inflammatory response; negative regulation of angiogenesis; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of cell-matrix adhesion; negative regulation of cGMP-mediated signaling; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of dendritic cell antigen processing and presentation; negative regulation of endothelial cell chemotaxis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fibrinolysis; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of focal adhesion assembly; negative regulation of interleukin-12 production; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of nitric oxide mediated signal transduction; negative regulation of plasminogen activation; negative regulation of sprouting angiogenesis; peptide cross-linking; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of chemotaxis; positive regulation of endothelial cell apoptotic process; positive regulation of endothelial cell migration; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of fibroblast migration; positive regulation of macrophage activation; positive regulation of macrophage chemotaxis; positive regulation of MAP kinase activity; positive regulation of phosphorylation; positive regulation of protein kinase B signaling; positive regulation of reactive oxygen species metabolic process; positive regulation of smooth muscle cell proliferation; positive regulation of transforming growth factor beta production; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transforming growth factor beta1 production; positive regulation of translation; positive regulation of tumor necrosis factor production; response to calcium ion; response to endoplasmic reticulum stress; response to glucose; response to hypoxia; response to magnesium ion; response to mechanical stimulus; response to progesterone; response to testosterone; response to unfolded protein; response to xenobiotic stimulus; sprouting angiogenesis","calcium ion binding; collagen V binding; extracellular matrix structural constituent; fibrinogen binding; fibroblast growth factor binding; fibronectin binding; heparin binding; identical protein binding; integrin binding; laminin binding; low-density lipoprotein particle binding; phosphatidylserine binding; protein binding; proteoglycan binding; transforming growth factor beta binding","cell surface; collagen-containing extracellular matrix; cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; external side of plasma membrane; extracellular exosome; extracellular matrix; extracellular region; extracellular space; fibrinogen complex; platelet alpha granule; platelet alpha granule lumen; sarcoplasmic reticulum; secretory granule","Cell adhesion","thrombospondin 1","http://www.ncbi.nlm.nih.gov/gene/?term=7057","7057","21825",null,null,"492313","705413","P07996","Q80YQ1","A0A0G2JV24","A0A8P0SDS3","F1SS26","F6WIY2","GO:0009986; GO:0062023; GO:0005737; GO:0005783; GO:0005788; GO:0009897; GO:0070062; GO:0031012; GO:0005576; GO:0005615; GO:0005577; GO:0031091; GO:0031093; GO:0016529; GO:0030141","GO:0005509; GO:0070052; GO:0005201; GO:0070051; GO:0017134; GO:0001968; GO:0008201; GO:0042802; GO:0005178; GO:0043236; GO:0030169; GO:0001786; GO:0005515; GO:0043394; GO:0050431","GO:0048266; GO:0007155; GO:0016477; GO:0071363; GO:0034605; GO:0071356; GO:0002544; GO:0043652; GO:0006955; GO:0006954; GO:0016525; GO:0002581; GO:0043066; GO:0043537; GO:1903588; GO:0090051; GO:0008285; GO:0001953; GO:0010754; GO:0043154; GO:0002605; GO:2001027; GO:0010596; GO:0001937; GO:2001237; GO:0051918; GO:0040037; GO:0051895; GO:0032695; GO:0010748; GO:0010751; GO:0010757; GO:1903671; GO:0018149; GO:0045766; GO:0030194; GO:0043536; GO:0030335; GO:0008284; GO:0050921; GO:2000353; GO:0010595; GO:1902043; GO:0010763; GO:0043032; GO:0010759; GO:0043406; GO:0042327; GO:0051897; GO:2000379; GO:0048661; GO:0071636; GO:0030511; GO:0032914; GO:0045727; GO:0032760; GO:0051592; GO:0034976; GO:0009749; GO:0001666; GO:0032026; GO:0009612; GO:0032570; GO:0033574; GO:0006986; GO:0009410; GO:0002040","PTHR10199:SF78","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11785|UniProtKB=P07996","P00059"]
["Twist",null,"TWIST1","28","rb",null,2,7,6,6,6,6,"BG/MP # 064",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .DDR., .DREP., .HIF., .MIG., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .SREME., .ST., .TRASR.",null,"TWIST-RELATED PROTEIN 1","aortic valve morphogenesis; bone development; cardiac neural crest cell development involved in outflow tract morphogenesis; cardiac neural crest cell migration involved in outflow tract morphogenesis; cell differentiation; cell proliferation involved in heart valve development; cellular response to growth factor stimulus; cellular response to hypoxia; cranial suture morphogenesis; developmental process; embryonic camera-type eye formation; embryonic cranial skeleton morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic skeletal system morphogenesis; endocardial cushion morphogenesis; eyelid development in camera-type eye; hindlimb morphogenesis; in utero embryonic development; mitral valve morphogenesis; muscle organ development; negative regulation of apoptotic process; negative regulation of cell differentiation; negative regulation of cellular senescence; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of double-strand break repair; negative regulation of histone acetylation; negative regulation of macrophage cytokine production; negative regulation of molecular function; negative regulation of osteoblast differentiation; negative regulation of oxidative phosphorylation uncoupler activity; negative regulation of peroxisome proliferator activated receptor signaling pathway; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of skeletal muscle tissue development; negative regulation of striated muscle tissue development; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; neural tube closure; neuron migration; odontogenesis; ossification; osteoblast differentiation; outer ear morphogenesis; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell motility; positive regulation of DNA-templated transcription initiation; positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of fatty acid beta-oxidation; positive regulation of gene expression; positive regulation of interleukin-6 production; positive regulation of monocyte chemotactic protein-1 production; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; positive regulation of tumor necrosis factor production; regulation of bone mineralization; regulation of transcription by RNA polymerase II; rhythmic process; roof of mouth development; stem cell differentiation","bHLH transcription factor binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; E-box binding; identical protein binding; protein binding; protein dimerization activity; protein domain specific binding; protein homodimerization activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription coregulator binding","chromatin; nucleoplasm; nucleus",null,"twist family bHLH transcription factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=7291","7291","22160","85489",null,null,null,"Q15672","P26687","Q9EPJ1",null,null,null,"GO:0000785; GO:0005654; GO:0005634","GO:0043425; GO:0003677; GO:0003700; GO:0000981; GO:0140297; GO:0070888; GO:0042802; GO:0005515; GO:0046983; GO:0019904; GO:0042803; GO:0000977; GO:0001221","GO:0003180; GO:0060348; GO:0061309; GO:0003253; GO:0030154; GO:2000793; GO:0071363; GO:0071456; GO:0060363; GO:0032502; GO:0060900; GO:0048701; GO:0042733; GO:0035115; GO:0035116; GO:0030326; GO:0048704; GO:0003203; GO:0061029; GO:0035137; GO:0001701; GO:0003183; GO:0007517; GO:0043066; GO:0045596; GO:2000773; GO:0043518; GO:0043433; GO:0045892; GO:2000780; GO:0035067; GO:0010936; GO:0044092; GO:0045668; GO:2000276; GO:0035359; GO:0014067; GO:0048642; GO:0045843; GO:0000122; GO:0032720; GO:0001843; GO:0001764; GO:0042476; GO:0001503; GO:0001649; GO:0042473; GO:0045766; GO:0030335; GO:2000147; GO:2000144; GO:2000802; GO:0050679; GO:0010718; GO:0032000; GO:0010628; GO:0032755; GO:0071639; GO:0045944; GO:2000679; GO:0032760; GO:0030500; GO:0006357; GO:0048511; GO:0060021; GO:0048863","PTHR23349:SF64","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12428|UniProtKB=Q15672"]
["UGT1A1",null,"UGT1A1","60","rb",null,2,2,"n/a","n/a","n/a","n/a","# 2022",".DRR., .IMFR., .IMUR., .OP., .OT.","Nicotine degradation","UDP-GLUCURONOSYLTRANSFERASE 1A1","acute-phase response; animal organ regeneration; bilirubin conjugation; biphenyl catabolic process; cellular glucuronidation; cellular response to estradiol stimulus; cellular response to ethanol; cellular response to glucocorticoid stimulus; cellular response to hormone stimulus; cellular response to xenobiotic stimulus; estrogen metabolic process; flavone metabolic process; flavonoid glucuronidation; heterocycle metabolic process; lipid metabolic process; liver development; negative regulation of steroid metabolic process; response to ethanol; response to glucocorticoid; response to lipopolysaccharide; response to nutrient; response to organic cyclic compound; response to organic substance; response to starvation; response to steroid hormone; response to xenobiotic stimulus; retinoic acid metabolic process; steroid metabolic process; xenobiotic glucuronidation; xenobiotic metabolic process","enzyme binding; enzyme inhibitor activity; glucuronosyltransferase activity; glycosyltransferase activity; protein homodimerization activity; retinoic acid binding; steroid binding; transferase activity; UDP-glycosyltransferase activity","cytochrome complex; cytoplasm; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; perinuclear region of cytoplasm; plasma membrane",null,"UDP glucuronosyltransferase family 1 member A1","http://www.ncbi.nlm.nih.gov/gene/?term=54658","54658","394436","24861",null,null,null,"P22309","Q63886","Q64550",null,null,null,"GO:0070069; GO:0005737; GO:0005783; GO:0034663; GO:0005789; GO:0043231; GO:0016020; GO:0048471; GO:0005886","GO:0019899; GO:0004857; GO:0015020; GO:0016757; GO:0042803; GO:0001972; GO:0005496; GO:0016740; GO:0008194","GO:0006953; GO:0031100; GO:0006789; GO:0070980; GO:0052695; GO:0071392; GO:0071361; GO:0071385; GO:0032870; GO:0071466; GO:0008210; GO:0051552; GO:0052696; GO:0046483; GO:0006629; GO:0001889; GO:0045939; GO:0045471; GO:0051384; GO:0032496; GO:0007584; GO:0014070; GO:0010033; GO:0042594; GO:0048545; GO:0009410; GO:0042573; GO:0008202; GO:0052697; GO:0006805","PTHR48050:SF8","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12530|UniProtKB=P22309","P05914"]
["ULK1",null,"ULK1","150","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1649",".ALZ., .AMPK., .APH., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .HUNT., .MTOR., .OP., .OPA., .RTK., .SREME., .ST.",null,"SERINE/THREONINE-PROTEIN KINASE ULK1","autophagosome assembly; autophagy; autophagy of mitochondrion; axon extension; axonogenesis; cellular response to nutrient levels; late nucleophagy; macroautophagy; negative regulation of cell population proliferation; negative regulation of collateral sprouting; negative regulation of protein-containing complex assembly; neuron projection development; neuron projection regeneration; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; piecemeal microautophagy of the nucleus; positive regulation of autophagosome assembly; positive regulation of autophagy; protein autophosphorylation; protein localization; protein phosphorylation; regulation of macroautophagy; regulation of protein lipidation; response to starvation; reticulophagy; signal transduction","ATP binding; GTPase binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; small GTPase binding; transferase activity","Atg1/ULK1 kinase complex; autophagosome; axon; cytoplasm; cytosol; endoplasmic reticulum membrane; extrinsic component of omegasome membrane; extrinsic component of phagophore assembly site membrane; mitochondrial outer membrane; phagophore assembly site; phagophore assembly site membrane; recycling endosome",null,"unc-51 like autophagy activating kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=8408","8408",null,null,null,null,null,"O75385","A0A0G2JFU2","A0A8I6GA79","A0A8P0SC13","A0A287APU3","A0A5F8AH52","GO:1990316; GO:0005776; GO:0030424; GO:0005737; GO:0005829; GO:0005789; GO:0097629; GO:0097632; GO:0005741; GO:0000407; GO:0034045; GO:0055037","GO:0005524; GO:0051020; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0031267; GO:0016740","GO:0000045; GO:0006914; GO:0000422; GO:0048675; GO:0007409; GO:0031669; GO:0044805; GO:0016236; GO:0008285; GO:0048671; GO:0031333; GO:0031175; GO:0031102; GO:0018105; GO:0018107; GO:0016310; GO:0034727; GO:2000786; GO:0010508; GO:0046777; GO:0008104; GO:0006468; GO:0016241; GO:1903059; GO:0042594; GO:0061709; GO:0007165","PTHR24348:SF19","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12558|UniProtKB=O75385"]
["ULK1 - phospho","Ser555","ULK1","150-140","rb",null,4,4,"n/a","n/a","n/a","n/a","# 2497",".ALZ., .AMPK., .APH., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .HUNT., .MTOR., .OP., .OPA., .RTK., .SREME., .ST.",null,"SERINE/THREONINE-PROTEIN KINASE ULK1","autophagosome assembly; autophagy; autophagy of mitochondrion; axon extension; axonogenesis; cellular response to nutrient levels; late nucleophagy; macroautophagy; negative regulation of cell population proliferation; negative regulation of collateral sprouting; negative regulation of protein-containing complex assembly; neuron projection development; neuron projection regeneration; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; piecemeal microautophagy of the nucleus; positive regulation of autophagosome assembly; positive regulation of autophagy; protein autophosphorylation; protein localization; protein phosphorylation; regulation of macroautophagy; regulation of protein lipidation; response to starvation; reticulophagy; signal transduction","ATP binding; GTPase binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; small GTPase binding; transferase activity","Atg1/ULK1 kinase complex; autophagosome; axon; cytoplasm; cytosol; endoplasmic reticulum membrane; extrinsic component of omegasome membrane; extrinsic component of phagophore assembly site membrane; mitochondrial outer membrane; phagophore assembly site; phagophore assembly site membrane; recycling endosome",null,"unc-51 like autophagy activating kinase 1","http://www.ncbi.nlm.nih.gov/gene/?term=8408","8408",null,null,null,null,null,"O75385","A0A0G2JFU2","A0A8I6GA79","A0A8P0SC13","A0A287APU3","A0A5F8AH52","GO:1990316; GO:0005776; GO:0030424; GO:0005737; GO:0005829; GO:0005789; GO:0097629; GO:0097632; GO:0005741; GO:0000407; GO:0034045; GO:0055037","GO:0005524; GO:0051020; GO:0042802; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0106310; GO:0004674; GO:0044877; GO:0031267; GO:0016740","GO:0000045; GO:0006914; GO:0000422; GO:0048675; GO:0007409; GO:0031669; GO:0044805; GO:0016236; GO:0008285; GO:0048671; GO:0031333; GO:0031175; GO:0031102; GO:0018105; GO:0018107; GO:0016310; GO:0034727; GO:2000786; GO:0010508; GO:0046777; GO:0008104; GO:0006468; GO:0016241; GO:1903059; GO:0042594; GO:0061709; GO:0007165","PTHR24348:SF19","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12558|UniProtKB=O75385"]
["VASP",null,"VASP","50, 46","rb",null,1,1.1000000000000001,8,8,8,1,"# 1576",".CSP., .INT., .OP., .OPA., .OT., .PLAT.","Axon guidance mediated by netrin; Cytoskeletal regulation by Rho GTPase; Integrin signalling pathway","VASODILATOR-STIMULATED PHOSPHOPROTEIN","actin cytoskeleton organization; actin polymerization or depolymerization; axon guidance; neural tube closure; positive regulation of actin filament polymerization; protein homotetramerization","actin binding; cadherin binding; profilin binding; protein binding; SH3 domain binding","actin cytoskeleton; anchoring junction; bicellular tight junction; cell projection; cytoplasm; cytoskeleton; cytosol; extracellular exosome; filopodium; filopodium membrane; focal adhesion; lamellipodium; lamellipodium membrane; membrane; plasma membrane",null,"vasodilator stimulated phosphoprotein","http://www.ncbi.nlm.nih.gov/gene/?term=7408","7408","22323",null,null,null,null,"P50552","P70460","A0A0G2K9C0","A0A8I3MUF9",null,"F6U702","GO:0015629; GO:0070161; GO:0005923; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0030175; GO:0031527; GO:0005925; GO:0030027; GO:0031258; GO:0016020; GO:0005886","GO:0003779; GO:0045296; GO:0005522; GO:0005515; GO:0017124","GO:0030036; GO:0008154; GO:0007411; GO:0001843; GO:0030838; GO:0051289","PTHR11202:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12652|UniProtKB=P50552","P00009; P00016; P00034"]
["VASP - phospho","Ser157","VASP","50","rb",null,1,1.1000000000000001,7,8,8,8,"# 1574",".CSP., .INT., .OP., .OPA., .OT., .PLAT.","Axon guidance mediated by netrin; Cytoskeletal regulation by Rho GTPase; Integrin signalling pathway","VASODILATOR-STIMULATED PHOSPHOPROTEIN","actin cytoskeleton organization; actin polymerization or depolymerization; axon guidance; neural tube closure; positive regulation of actin filament polymerization; protein homotetramerization","actin binding; cadherin binding; profilin binding; protein binding; SH3 domain binding","actin cytoskeleton; anchoring junction; bicellular tight junction; cell projection; cytoplasm; cytoskeleton; cytosol; extracellular exosome; filopodium; filopodium membrane; focal adhesion; lamellipodium; lamellipodium membrane; membrane; plasma membrane",null,"vasodilator stimulated phosphoprotein","http://www.ncbi.nlm.nih.gov/gene/?term=7408","7408","22323",null,null,null,null,"P50552","P70460","A0A0G2K9C0","A0A8I3MUF9",null,"F6U702","GO:0015629; GO:0070161; GO:0005923; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0030175; GO:0031527; GO:0005925; GO:0030027; GO:0031258; GO:0016020; GO:0005886","GO:0003779; GO:0045296; GO:0005522; GO:0005515; GO:0017124","GO:0030036; GO:0008154; GO:0007411; GO:0001843; GO:0030838; GO:0051289","PTHR11202:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12652|UniProtKB=P50552","P00009; P00016; P00034"]
["VASP - phospho","Ser239","VASP","50, 48","rb",null,6,1.1000000000000001,8,8,8,8,"# 1575",".CSP., .INT., .OP., .OPA., .OT., .PLAT.","Axon guidance mediated by netrin; Cytoskeletal regulation by Rho GTPase; Integrin signalling pathway","VASODILATOR-STIMULATED PHOSPHOPROTEIN","actin cytoskeleton organization; actin polymerization or depolymerization; axon guidance; neural tube closure; positive regulation of actin filament polymerization; protein homotetramerization","actin binding; cadherin binding; profilin binding; protein binding; SH3 domain binding","actin cytoskeleton; anchoring junction; bicellular tight junction; cell projection; cytoplasm; cytoskeleton; cytosol; extracellular exosome; filopodium; filopodium membrane; focal adhesion; lamellipodium; lamellipodium membrane; membrane; plasma membrane",null,"vasodilator stimulated phosphoprotein","http://www.ncbi.nlm.nih.gov/gene/?term=7408","7408","22323",null,null,null,null,"P50552","P70460","A0A0G2K9C0","A0A8I3MUF9",null,"F6U702","GO:0015629; GO:0070161; GO:0005923; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0030175; GO:0031527; GO:0005925; GO:0030027; GO:0031258; GO:0016020; GO:0005886","GO:0003779; GO:0045296; GO:0005522; GO:0005515; GO:0017124","GO:0030036; GO:0008154; GO:0007411; GO:0001843; GO:0030838; GO:0051289","PTHR11202:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12652|UniProtKB=P50552","P00009; P00016; P00034"]
["VE-Cadherin",null,"CDH5","140-130","rb",null,1,8,8,7,1,1,"# 1477",".ANG., .BMP., .CADH., .CANCER., .CCP., .CP., .CSP., .DEV., .IMFR., .IMUR., .MIG., .OP., .OPA., .OT., .ST., .TGFB., .TRASR., .WNT.","Cadherin signaling pathway; Wnt signaling pathway","CADHERIN-5","adherens junction organization; bicellular tight junction assembly; blood vessel endothelial cell migration; blood vessel maturation; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell morphogenesis; cell-cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell adhesion via plasma-membrane adhesion molecules; cell-cell junction assembly; cellular calcium ion homeostasis; homophilic cell adhesion via plasma membrane adhesion molecules; maintenance of blood-brain barrier; negative regulation of cell population proliferation; negative regulation of endothelial cell apoptotic process; negative regulation of inflammatory response; negative regulation of microtubule polymerization; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cell migration; positive regulation of establishment of endothelial barrier; positive regulation of gene expression; positive regulation of protein dephosphorylation; positive regulation of protein-containing complex assembly; protein localization to bicellular tight junction; regulation of establishment of cell polarity; regulation of protein phosphorylation; regulation of vascular permeability; transforming growth factor beta receptor signaling pathway; vasculature development","beta-catenin binding; BMP receptor binding; cadherin binding; calcium ion binding; fibrinogen binding; metal ion binding; protein binding; protein phosphatase binding; protein tyrosine kinase binding; signaling receptor binding; transmembrane transporter binding; vascular endothelial growth factor receptor 2 binding","adherens junction; anchoring junction; bicellular tight junction; catenin complex; cell junction; cell periphery; cell surface; cell-cell junction; external side of plasma membrane; membrane; nuclear membrane; nucleoplasm; plasma membrane","Adhesion","cadherin 5","http://www.ncbi.nlm.nih.gov/gene/?term=1003","1003","12562",null,"489775",null,"693297","P33151","P55284","A0A0G2K0I6","A0A8I3NHK1",null,"F6RFA8","GO:0005912; GO:0070161; GO:0005923; GO:0016342; GO:0030054; GO:0071944; GO:0009986; GO:0005911; GO:0009897; GO:0016020; GO:0031965; GO:0005654; GO:0005886","GO:0008013; GO:0070700; GO:0045296; GO:0005509; GO:0070051; GO:0046872; GO:0005515; GO:0019903; GO:1990782; GO:0005102; GO:0044325; GO:0043184","GO:0034332; GO:0070830; GO:0043534; GO:0001955; GO:0016339; GO:0007155; GO:0000902; GO:0098609; GO:0044331; GO:0098742; GO:0007043; GO:0006874; GO:0007156; GO:0035633; GO:0008285; GO:2000352; GO:0050728; GO:0031115; GO:0045766; GO:0030513; GO:0030335; GO:1903142; GO:0010628; GO:0035307; GO:0031334; GO:1902396; GO:2000114; GO:0001932; GO:0043114; GO:0007179; GO:0001944","PTHR24027:SF89","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=1764|UniProtKB=P33151","P00012; P00057"]
["VEGF (Ab-3)",null,"VEGFA","50-31","ms",null,2,2,2,6,2,2,"# 0738",".ANG., .APO., .BLC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .EGFR., .HIF., .IMUR., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .PAC., .PI3K., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TRASR., .VEGFS.","VEGF signaling pathway; Angiogenesis","VASCULAR ENDOTHELIAL GROWTH FACTOR A","activation of protein kinase activity; angiogenesis; artery morphogenesis; branching involved in blood vessel morphogenesis; camera-type eye morphogenesis; cardiac muscle cell development; cardiac vascular smooth muscle cell development; cell differentiation; cell maturation; cell migration involved in sprouting angiogenesis; cellular response to hypoxia; cellular response to vascular endothelial growth factor stimulus; cellular stress response to acid chemical; commissural neuron axon guidance; coronary artery morphogenesis; coronary vein morphogenesis; dopaminergic neuron differentiation; endothelial cell chemotaxis; epithelial cell differentiation; eye photoreceptor cell development; heart morphogenesis; in utero embryonic development; induction of positive chemotaxis; kidney development; lactation; lung development; lymph vessel morphogenesis; macrophage differentiation; mammary gland alveolus development; mesoderm development; monocyte differentiation; motor neuron migration; negative regulation of adherens junction organization; negative regulation of apoptotic process; negative regulation of blood-brain barrier permeability; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of establishment of endothelial barrier; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; nervous system development; outflow tract morphogenesis; ovarian follicle development; positive chemotaxis; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of blood vessel endothelial cell migration; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cell adhesion; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell population proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of cold-induced thermogenesis; positive regulation of CREB transcription factor activity; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of histone deacetylase activity; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of mast cell chemotaxis; positive regulation of neuroblast proliferation; positive regulation of p38MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein autophosphorylation; positive regulation of protein kinase C signaling; positive regulation of protein kinase D signaling; positive regulation of protein phosphorylation; positive regulation of protein-containing complex assembly; positive regulation of receptor internalization; positive regulation of retinal ganglion cell axon guidance; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of trophoblast cell migration; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial growth factor signaling pathway; positive regulation of vascular permeability; post-embryonic camera-type eye development; primitive erythrocyte differentiation; regulation of cell shape; regulation of nitric oxide mediated signal transduction; regulation of retinal ganglion cell axon guidance; response to hypoxia; sprouting angiogenesis; surfactant homeostasis; tube formation; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor receptor-2 signaling pathway; vascular endothelial growth factor signaling pathway; vascular wound healing; vasculogenesis; VEGF-activated neuropilin signaling pathway","chemoattractant activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; heparin binding; identical protein binding; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity; receptor ligand activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor binding","adherens junction; cell surface; cytoplasm; extracellular matrix; extracellular region; extracellular space; membrane; platelet alpha granule lumen; secretory granule; VEGF-A complex","Growth Factors / cytokines","vascular endothelial growth factor A","http://www.ncbi.nlm.nih.gov/gene/?term=7422","7422","22339","83785",null,null,null,"P15692","Q00731","P16612","A0A8P0NSP1","A0A287BFL9","A0A1D5QPJ0","GO:0005912; GO:0009986; GO:0005737; GO:0031012; GO:0005576; GO:0005615; GO:0016020; GO:0031093; GO:0030141; GO:1990150","GO:0042056; GO:0005125; GO:0050840; GO:0001968; GO:0008083; GO:0008201; GO:0042802; GO:0005161; GO:0005515; GO:0042803; GO:0048018; GO:0043183; GO:0043184; GO:0005172","GO:0032147; GO:0001525; GO:0048844; GO:0001569; GO:0048593; GO:0055013; GO:0060948; GO:0030154; GO:0048469; GO:0002042; GO:0071456; GO:0035924; GO:0097533; GO:0071679; GO:0060982; GO:0003169; GO:0071542; GO:0035767; GO:0030855; GO:0042462; GO:0003007; GO:0001701; GO:0050930; GO:0001822; GO:0007595; GO:0030324; GO:0036303; GO:0030225; GO:0060749; GO:0007498; GO:0030224; GO:0097475; GO:1903392; GO:0043066; GO:1905604; GO:2000048; GO:0043154; GO:1903141; GO:0010629; GO:0000122; GO:0007399; GO:0003151; GO:0001541; GO:0050918; GO:0045766; GO:0048842; GO:0043536; GO:1903589; GO:0090190; GO:0045785; GO:0051781; GO:0030335; GO:0090050; GO:0008284; GO:0038091; GO:0120162; GO:0032793; GO:0038033; GO:0010595; GO:0001938; GO:0050679; GO:0051894; GO:0010628; GO:1901727; GO:0002687; GO:0043406; GO:0060754; GO:0002052; GO:1900745; GO:0033138; GO:1900086; GO:0050731; GO:0050927; GO:0031954; GO:0090037; GO:1903572; GO:0001934; GO:0031334; GO:0002092; GO:1902336; GO:1903672; GO:0045944; GO:0061419; GO:1901165; GO:0042531; GO:1900748; GO:0043117; GO:0031077; GO:0060319; GO:0008360; GO:0010749; GO:0090259; GO:0001666; GO:0002040; GO:0043129; GO:0035148; GO:0048010; GO:0036324; GO:0038084; GO:0061042; GO:0001570; GO:0038190","PTHR12025:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12680|UniProtKB=P15692","P00056; P00005"]
["VEGF-A",null,"VEGFA","50-34","rb",null,6,2,"n/a","n/a","n/a","n/a","# 0321",".ANG., .APO., .BLC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .EGFR., .HIF., .IMUR., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .PAC., .PI3K., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TRASR., .VEGFS.","VEGF signaling pathway; Angiogenesis","VASCULAR ENDOTHELIAL GROWTH FACTOR A","activation of protein kinase activity; angiogenesis; artery morphogenesis; branching involved in blood vessel morphogenesis; camera-type eye morphogenesis; cardiac muscle cell development; cardiac vascular smooth muscle cell development; cell differentiation; cell maturation; cell migration involved in sprouting angiogenesis; cellular response to hypoxia; cellular response to vascular endothelial growth factor stimulus; cellular stress response to acid chemical; commissural neuron axon guidance; coronary artery morphogenesis; coronary vein morphogenesis; dopaminergic neuron differentiation; endothelial cell chemotaxis; epithelial cell differentiation; eye photoreceptor cell development; heart morphogenesis; in utero embryonic development; induction of positive chemotaxis; kidney development; lactation; lung development; lymph vessel morphogenesis; macrophage differentiation; mammary gland alveolus development; mesoderm development; monocyte differentiation; motor neuron migration; negative regulation of adherens junction organization; negative regulation of apoptotic process; negative regulation of blood-brain barrier permeability; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of establishment of endothelial barrier; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; nervous system development; outflow tract morphogenesis; ovarian follicle development; positive chemotaxis; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of blood vessel endothelial cell migration; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cell adhesion; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell population proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of cold-induced thermogenesis; positive regulation of CREB transcription factor activity; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of histone deacetylase activity; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of mast cell chemotaxis; positive regulation of neuroblast proliferation; positive regulation of p38MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein autophosphorylation; positive regulation of protein kinase C signaling; positive regulation of protein kinase D signaling; positive regulation of protein phosphorylation; positive regulation of protein-containing complex assembly; positive regulation of receptor internalization; positive regulation of retinal ganglion cell axon guidance; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of trophoblast cell migration; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial growth factor signaling pathway; positive regulation of vascular permeability; post-embryonic camera-type eye development; primitive erythrocyte differentiation; regulation of cell shape; regulation of nitric oxide mediated signal transduction; regulation of retinal ganglion cell axon guidance; response to hypoxia; sprouting angiogenesis; surfactant homeostasis; tube formation; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor receptor-2 signaling pathway; vascular endothelial growth factor signaling pathway; vascular wound healing; vasculogenesis; VEGF-activated neuropilin signaling pathway","chemoattractant activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; heparin binding; identical protein binding; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity; receptor ligand activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor binding","adherens junction; cell surface; cytoplasm; extracellular matrix; extracellular region; extracellular space; membrane; platelet alpha granule lumen; secretory granule; VEGF-A complex","Growth Factors / cytokines","vascular endothelial growth factor A","http://www.ncbi.nlm.nih.gov/gene/?term=7422","7422","22339","83785",null,null,null,"P15692","Q00731","P16612","A0A8P0NSP1","A0A287BFL9","A0A1D5QPJ0","GO:0005912; GO:0009986; GO:0005737; GO:0031012; GO:0005576; GO:0005615; GO:0016020; GO:0031093; GO:0030141; GO:1990150","GO:0042056; GO:0005125; GO:0050840; GO:0001968; GO:0008083; GO:0008201; GO:0042802; GO:0005161; GO:0005515; GO:0042803; GO:0048018; GO:0043183; GO:0043184; GO:0005172","GO:0032147; GO:0001525; GO:0048844; GO:0001569; GO:0048593; GO:0055013; GO:0060948; GO:0030154; GO:0048469; GO:0002042; GO:0071456; GO:0035924; GO:0097533; GO:0071679; GO:0060982; GO:0003169; GO:0071542; GO:0035767; GO:0030855; GO:0042462; GO:0003007; GO:0001701; GO:0050930; GO:0001822; GO:0007595; GO:0030324; GO:0036303; GO:0030225; GO:0060749; GO:0007498; GO:0030224; GO:0097475; GO:1903392; GO:0043066; GO:1905604; GO:2000048; GO:0043154; GO:1903141; GO:0010629; GO:0000122; GO:0007399; GO:0003151; GO:0001541; GO:0050918; GO:0045766; GO:0048842; GO:0043536; GO:1903589; GO:0090190; GO:0045785; GO:0051781; GO:0030335; GO:0090050; GO:0008284; GO:0038091; GO:0120162; GO:0032793; GO:0038033; GO:0010595; GO:0001938; GO:0050679; GO:0051894; GO:0010628; GO:1901727; GO:0002687; GO:0043406; GO:0060754; GO:0002052; GO:1900745; GO:0033138; GO:1900086; GO:0050731; GO:0050927; GO:0031954; GO:0090037; GO:1903572; GO:0001934; GO:0031334; GO:0002092; GO:1902336; GO:1903672; GO:0045944; GO:0061419; GO:1901165; GO:0042531; GO:1900748; GO:0043117; GO:0031077; GO:0060319; GO:0008360; GO:0010749; GO:0090259; GO:0001666; GO:0002040; GO:0043129; GO:0035148; GO:0048010; GO:0036324; GO:0038084; GO:0061042; GO:0001570; GO:0038190","PTHR12025:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12680|UniProtKB=P15692","P00056; P00005"]
["VEGF-A",null,"VEGFA","45","ms",null,2,7,8,8,8,8,"# 1675",".ANG., .APO., .BLC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DRAS., .EGFR., .HIF., .IMUR., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .PAC., .PI3K., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TRASR., .VEGFS.","VEGF signaling pathway; Angiogenesis","VASCULAR ENDOTHELIAL GROWTH FACTOR A","activation of protein kinase activity; angiogenesis; artery morphogenesis; branching involved in blood vessel morphogenesis; camera-type eye morphogenesis; cardiac muscle cell development; cardiac vascular smooth muscle cell development; cell differentiation; cell maturation; cell migration involved in sprouting angiogenesis; cellular response to hypoxia; cellular response to vascular endothelial growth factor stimulus; cellular stress response to acid chemical; commissural neuron axon guidance; coronary artery morphogenesis; coronary vein morphogenesis; dopaminergic neuron differentiation; endothelial cell chemotaxis; epithelial cell differentiation; eye photoreceptor cell development; heart morphogenesis; in utero embryonic development; induction of positive chemotaxis; kidney development; lactation; lung development; lymph vessel morphogenesis; macrophage differentiation; mammary gland alveolus development; mesoderm development; monocyte differentiation; motor neuron migration; negative regulation of adherens junction organization; negative regulation of apoptotic process; negative regulation of blood-brain barrier permeability; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of establishment of endothelial barrier; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; nervous system development; outflow tract morphogenesis; ovarian follicle development; positive chemotaxis; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of blood vessel endothelial cell migration; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cell adhesion; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell population proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of cold-induced thermogenesis; positive regulation of CREB transcription factor activity; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of histone deacetylase activity; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of mast cell chemotaxis; positive regulation of neuroblast proliferation; positive regulation of p38MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein autophosphorylation; positive regulation of protein kinase C signaling; positive regulation of protein kinase D signaling; positive regulation of protein phosphorylation; positive regulation of protein-containing complex assembly; positive regulation of receptor internalization; positive regulation of retinal ganglion cell axon guidance; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of trophoblast cell migration; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial growth factor signaling pathway; positive regulation of vascular permeability; post-embryonic camera-type eye development; primitive erythrocyte differentiation; regulation of cell shape; regulation of nitric oxide mediated signal transduction; regulation of retinal ganglion cell axon guidance; response to hypoxia; sprouting angiogenesis; surfactant homeostasis; tube formation; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor receptor-2 signaling pathway; vascular endothelial growth factor signaling pathway; vascular wound healing; vasculogenesis; VEGF-activated neuropilin signaling pathway","chemoattractant activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; heparin binding; identical protein binding; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity; receptor ligand activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor binding","adherens junction; cell surface; cytoplasm; extracellular matrix; extracellular region; extracellular space; membrane; platelet alpha granule lumen; secretory granule; VEGF-A complex","Growth Factors / cytokines","vascular endothelial growth factor A","http://www.ncbi.nlm.nih.gov/gene/?term=7422","7422","22339","83785",null,null,null,"P15692","Q00731","P16612","A0A8P0NSP1","A0A287BFL9","A0A1D5QPJ0","GO:0005912; GO:0009986; GO:0005737; GO:0031012; GO:0005576; GO:0005615; GO:0016020; GO:0031093; GO:0030141; GO:1990150","GO:0042056; GO:0005125; GO:0050840; GO:0001968; GO:0008083; GO:0008201; GO:0042802; GO:0005161; GO:0005515; GO:0042803; GO:0048018; GO:0043183; GO:0043184; GO:0005172","GO:0032147; GO:0001525; GO:0048844; GO:0001569; GO:0048593; GO:0055013; GO:0060948; GO:0030154; GO:0048469; GO:0002042; GO:0071456; GO:0035924; GO:0097533; GO:0071679; GO:0060982; GO:0003169; GO:0071542; GO:0035767; GO:0030855; GO:0042462; GO:0003007; GO:0001701; GO:0050930; GO:0001822; GO:0007595; GO:0030324; GO:0036303; GO:0030225; GO:0060749; GO:0007498; GO:0030224; GO:0097475; GO:1903392; GO:0043066; GO:1905604; GO:2000048; GO:0043154; GO:1903141; GO:0010629; GO:0000122; GO:0007399; GO:0003151; GO:0001541; GO:0050918; GO:0045766; GO:0048842; GO:0043536; GO:1903589; GO:0090190; GO:0045785; GO:0051781; GO:0030335; GO:0090050; GO:0008284; GO:0038091; GO:0120162; GO:0032793; GO:0038033; GO:0010595; GO:0001938; GO:0050679; GO:0051894; GO:0010628; GO:1901727; GO:0002687; GO:0043406; GO:0060754; GO:0002052; GO:1900745; GO:0033138; GO:1900086; GO:0050731; GO:0050927; GO:0031954; GO:0090037; GO:1903572; GO:0001934; GO:0031334; GO:0002092; GO:1902336; GO:1903672; GO:0045944; GO:0061419; GO:1901165; GO:0042531; GO:1900748; GO:0043117; GO:0031077; GO:0060319; GO:0008360; GO:0010749; GO:0090259; GO:0001666; GO:0002040; GO:0043129; GO:0035148; GO:0048010; GO:0036324; GO:0038084; GO:0061042; GO:0001570; GO:0038190","PTHR12025:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12680|UniProtKB=P15692","P00056; P00005"]
["VEGF-B",null,"VEGFB","50-31","rb",null,4,3,"n/a","n/a","n/a","n/a","# 2102",".ANG., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .HIF., .IMUR., .LMIG., .MAPK., .OP., .OPA., .PI3K., .RAS., .RTK., .SREME., .ST., .VEGFS.",null,"VASCULAR ENDOTHELIAL GROWTH FACTOR B","cardiac muscle contraction; coronary vasculature development; heart development; induction of positive chemotaxis; positive chemotaxis; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cell population proliferation; positive regulation of endothelial cell proliferation; positive regulation of mast cell chemotaxis; positive regulation of protein phosphorylation; protein O-linked glycosylation; response to hypoxia; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway","chemoattractant activity; growth factor activity; heparin binding; identical protein binding; protein binding; receptor ligand activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor binding","extracellular region; extracellular space; membrane; platelet alpha granule lumen",null,"vascular endothelial growth factor B","http://www.ncbi.nlm.nih.gov/gene/?term=7423","7423","22340","89811","476036",null,"722115","P49765","P49766","O35485","A0A8P0SJ74",null,"F6RJK6","GO:0005576; GO:0005615; GO:0016020; GO:0031093","GO:0042056; GO:0008083; GO:0008201; GO:0042802; GO:0005515; GO:0048018; GO:0043183; GO:0005172","GO:0060048; GO:0060976; GO:0007507; GO:0050930; GO:0050918; GO:0045766; GO:0051781; GO:0008284; GO:0001938; GO:0060754; GO:0001934; GO:0006493; GO:0001666; GO:0002040; GO:0048010; GO:0038084","PTHR12025:SF12","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12681|UniProtKB=P49765"]
["VEGFR 2 (FLK-1)",null,"KDR","230, 210","rb",null,2,7,8,7,1,1,"# 1447",".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","VEGF signaling pathway; Angiogenesis","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","angiogenesis; blood vessel endothelial cell differentiation; branching involved in blood vessel morphogenesis; branching morphogenesis of an epithelial tube; calcium ion homeostasis; calcium-mediated signaling using intracellular calcium source; cell differentiation; cell fate commitment; cell migration; cell migration involved in sprouting angiogenesis; cellular response to hydrogen sulfide; cellular response to vascular endothelial growth factor stimulus; embryonic hemopoiesis; endocardium development; endothelial cell differentiation; endothelium development; epithelial cell maturation; epithelial cell proliferation; ERK1 and ERK2 cascade; hematopoietic progenitor cell differentiation; hemopoiesis; lung alveolus development; lung development; lymph vessel development; mesenchymal cell proliferation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of gene expression; negative regulation of neuron apoptotic process; ovarian follicle development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of BMP signaling pathway; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell population proliferation; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of kinase activity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of stem cell proliferation; positive regulation of vasculogenesis; post-embryonic camera-type eye morphogenesis; protein autophosphorylation; protein kinase B signaling; protein phosphorylation; regulation of bone development; regulation of cell shape; regulation of hematopoietic progenitor cell differentiation; regulation of MAPK cascade; semaphorin-plexin signaling pathway; stem cell proliferation; surfactant homeostasis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor receptor-2 signaling pathway; vascular endothelial growth factor signaling pathway; vascular wound healing; vasculogenesis","ATP binding; cadherin binding; coreceptor activity; growth factor binding; Hsp90 protein binding; identical protein binding; integrin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding; vascular endothelial growth factor receptor activity","anchoring junction; cell junction; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; early endosome; endoplasmic reticulum; endosome; external side of plasma membrane; extracellular region; Golgi apparatus; membrane; membrane raft; nucleus; plasma membrane; receptor complex; sorting endosome","Tyrosine kinase / adaptor","kinase insert domain receptor","http://www.ncbi.nlm.nih.gov/gene/?term=3791","3791","16542",null,null,null,"698293","P35968","P35918","A0A0G2K090","A0A8I3NL69","A0A5G2QBK4","F7E313","GO:0070161; GO:0030054; GO:0071944; GO:0009986; GO:0005737; GO:0031410; GO:0005769; GO:0005783; GO:0005768; GO:0009897; GO:0005576; GO:0005794; GO:0016020; GO:0045121; GO:0005634; GO:0005886; GO:0043235; GO:0097443","GO:0005524; GO:0045296; GO:0015026; GO:0019838; GO:0051879; GO:0042802; GO:0005178; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0038085; GO:0005021","GO:0001525; GO:0060837; GO:0001569; GO:0048754; GO:0055074; GO:0035584; GO:0030154; GO:0045165; GO:0016477; GO:0002042; GO:1904881; GO:0035924; GO:0035162; GO:0003157; GO:0045446; GO:0003158; GO:0002070; GO:0050673; GO:0070371; GO:0002244; GO:0030097; GO:0048286; GO:0030324; GO:0001945; GO:0010463; GO:0043066; GO:2000352; GO:0010629; GO:0043524; GO:0001541; GO:0038083; GO:0018108; GO:0016310; GO:0045766; GO:0043536; GO:0030513; GO:0030335; GO:0090050; GO:0008284; GO:0038033; GO:0010595; GO:0001938; GO:0050679; GO:0070374; GO:0051894; GO:0033674; GO:0016239; GO:0043410; GO:0002053; GO:0051901; GO:0090141; GO:0051770; GO:0014068; GO:0042327; GO:0050927; GO:0001934; GO:2000648; GO:2001214; GO:0048597; GO:0046777; GO:0043491; GO:0006468; GO:1903010; GO:0008360; GO:1901532; GO:0043408; GO:0071526; GO:0072089; GO:0043129; GO:0007169; GO:0048010; GO:0036324; GO:0038084; GO:0061042; GO:0001570","PTHR24416:SF45","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6307|UniProtKB=P35968","P00056; P00005"]
["VEGFR 2 (FLK-1)- phospho","Tyr1059","KDR","230","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1445",".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","VEGF signaling pathway; Angiogenesis","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","angiogenesis; blood vessel endothelial cell differentiation; branching involved in blood vessel morphogenesis; branching morphogenesis of an epithelial tube; calcium ion homeostasis; calcium-mediated signaling using intracellular calcium source; cell differentiation; cell fate commitment; cell migration; cell migration involved in sprouting angiogenesis; cellular response to hydrogen sulfide; cellular response to vascular endothelial growth factor stimulus; embryonic hemopoiesis; endocardium development; endothelial cell differentiation; endothelium development; epithelial cell maturation; epithelial cell proliferation; ERK1 and ERK2 cascade; hematopoietic progenitor cell differentiation; hemopoiesis; lung alveolus development; lung development; lymph vessel development; mesenchymal cell proliferation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of gene expression; negative regulation of neuron apoptotic process; ovarian follicle development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of BMP signaling pathway; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell population proliferation; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of kinase activity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of stem cell proliferation; positive regulation of vasculogenesis; post-embryonic camera-type eye morphogenesis; protein autophosphorylation; protein kinase B signaling; protein phosphorylation; regulation of bone development; regulation of cell shape; regulation of hematopoietic progenitor cell differentiation; regulation of MAPK cascade; semaphorin-plexin signaling pathway; stem cell proliferation; surfactant homeostasis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor receptor-2 signaling pathway; vascular endothelial growth factor signaling pathway; vascular wound healing; vasculogenesis","ATP binding; cadherin binding; coreceptor activity; growth factor binding; Hsp90 protein binding; identical protein binding; integrin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding; vascular endothelial growth factor receptor activity","anchoring junction; cell junction; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; early endosome; endoplasmic reticulum; endosome; external side of plasma membrane; extracellular region; Golgi apparatus; membrane; membrane raft; nucleus; plasma membrane; receptor complex; sorting endosome","Tyrosine kinase / adaptor","kinase insert domain receptor","http://www.ncbi.nlm.nih.gov/gene/?term=3791","3791","16542",null,null,null,"698293","P35968","P35918","A0A0G2K090","A0A8I3NL69","A0A5G2QBK4","F7E313","GO:0070161; GO:0030054; GO:0071944; GO:0009986; GO:0005737; GO:0031410; GO:0005769; GO:0005783; GO:0005768; GO:0009897; GO:0005576; GO:0005794; GO:0016020; GO:0045121; GO:0005634; GO:0005886; GO:0043235; GO:0097443","GO:0005524; GO:0045296; GO:0015026; GO:0019838; GO:0051879; GO:0042802; GO:0005178; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0038085; GO:0005021","GO:0001525; GO:0060837; GO:0001569; GO:0048754; GO:0055074; GO:0035584; GO:0030154; GO:0045165; GO:0016477; GO:0002042; GO:1904881; GO:0035924; GO:0035162; GO:0003157; GO:0045446; GO:0003158; GO:0002070; GO:0050673; GO:0070371; GO:0002244; GO:0030097; GO:0048286; GO:0030324; GO:0001945; GO:0010463; GO:0043066; GO:2000352; GO:0010629; GO:0043524; GO:0001541; GO:0038083; GO:0018108; GO:0016310; GO:0045766; GO:0043536; GO:0030513; GO:0030335; GO:0090050; GO:0008284; GO:0038033; GO:0010595; GO:0001938; GO:0050679; GO:0070374; GO:0051894; GO:0033674; GO:0016239; GO:0043410; GO:0002053; GO:0051901; GO:0090141; GO:0051770; GO:0014068; GO:0042327; GO:0050927; GO:0001934; GO:2000648; GO:2001214; GO:0048597; GO:0046777; GO:0043491; GO:0006468; GO:1903010; GO:0008360; GO:1901532; GO:0043408; GO:0071526; GO:0072089; GO:0043129; GO:0007169; GO:0048010; GO:0036324; GO:0038084; GO:0061042; GO:0001570","PTHR24416:SF45","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6307|UniProtKB=P35968","P00056; P00005"]
["VEGFR 2 (FLK-1)- phospho","Tyr1175","KDR","230","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1446",".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","VEGF signaling pathway; Angiogenesis","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","angiogenesis; blood vessel endothelial cell differentiation; branching involved in blood vessel morphogenesis; branching morphogenesis of an epithelial tube; calcium ion homeostasis; calcium-mediated signaling using intracellular calcium source; cell differentiation; cell fate commitment; cell migration; cell migration involved in sprouting angiogenesis; cellular response to hydrogen sulfide; cellular response to vascular endothelial growth factor stimulus; embryonic hemopoiesis; endocardium development; endothelial cell differentiation; endothelium development; epithelial cell maturation; epithelial cell proliferation; ERK1 and ERK2 cascade; hematopoietic progenitor cell differentiation; hemopoiesis; lung alveolus development; lung development; lymph vessel development; mesenchymal cell proliferation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of gene expression; negative regulation of neuron apoptotic process; ovarian follicle development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of BMP signaling pathway; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell population proliferation; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of kinase activity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of stem cell proliferation; positive regulation of vasculogenesis; post-embryonic camera-type eye morphogenesis; protein autophosphorylation; protein kinase B signaling; protein phosphorylation; regulation of bone development; regulation of cell shape; regulation of hematopoietic progenitor cell differentiation; regulation of MAPK cascade; semaphorin-plexin signaling pathway; stem cell proliferation; surfactant homeostasis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor receptor-2 signaling pathway; vascular endothelial growth factor signaling pathway; vascular wound healing; vasculogenesis","ATP binding; cadherin binding; coreceptor activity; growth factor binding; Hsp90 protein binding; identical protein binding; integrin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding; vascular endothelial growth factor receptor activity","anchoring junction; cell junction; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; early endosome; endoplasmic reticulum; endosome; external side of plasma membrane; extracellular region; Golgi apparatus; membrane; membrane raft; nucleus; plasma membrane; receptor complex; sorting endosome","Tyrosine kinase / adaptor","kinase insert domain receptor","http://www.ncbi.nlm.nih.gov/gene/?term=3791","3791","16542",null,null,null,"698293","P35968","P35918","A0A0G2K090","A0A8I3NL69","A0A5G2QBK4","F7E313","GO:0070161; GO:0030054; GO:0071944; GO:0009986; GO:0005737; GO:0031410; GO:0005769; GO:0005783; GO:0005768; GO:0009897; GO:0005576; GO:0005794; GO:0016020; GO:0045121; GO:0005634; GO:0005886; GO:0043235; GO:0097443","GO:0005524; GO:0045296; GO:0015026; GO:0019838; GO:0051879; GO:0042802; GO:0005178; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0038085; GO:0005021","GO:0001525; GO:0060837; GO:0001569; GO:0048754; GO:0055074; GO:0035584; GO:0030154; GO:0045165; GO:0016477; GO:0002042; GO:1904881; GO:0035924; GO:0035162; GO:0003157; GO:0045446; GO:0003158; GO:0002070; GO:0050673; GO:0070371; GO:0002244; GO:0030097; GO:0048286; GO:0030324; GO:0001945; GO:0010463; GO:0043066; GO:2000352; GO:0010629; GO:0043524; GO:0001541; GO:0038083; GO:0018108; GO:0016310; GO:0045766; GO:0043536; GO:0030513; GO:0030335; GO:0090050; GO:0008284; GO:0038033; GO:0010595; GO:0001938; GO:0050679; GO:0070374; GO:0051894; GO:0033674; GO:0016239; GO:0043410; GO:0002053; GO:0051901; GO:0090141; GO:0051770; GO:0014068; GO:0042327; GO:0050927; GO:0001934; GO:2000648; GO:2001214; GO:0048597; GO:0046777; GO:0043491; GO:0006468; GO:1903010; GO:0008360; GO:1901532; GO:0043408; GO:0071526; GO:0072089; GO:0043129; GO:0007169; GO:0048010; GO:0036324; GO:0038084; GO:0061042; GO:0001570","PTHR24416:SF45","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6307|UniProtKB=P35968","P00056; P00005"]
["VEGFR 2 (FLK-1)- phospho","Tyr951","KDR","230","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1443",".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","VEGF signaling pathway; Angiogenesis","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","angiogenesis; blood vessel endothelial cell differentiation; branching involved in blood vessel morphogenesis; branching morphogenesis of an epithelial tube; calcium ion homeostasis; calcium-mediated signaling using intracellular calcium source; cell differentiation; cell fate commitment; cell migration; cell migration involved in sprouting angiogenesis; cellular response to hydrogen sulfide; cellular response to vascular endothelial growth factor stimulus; embryonic hemopoiesis; endocardium development; endothelial cell differentiation; endothelium development; epithelial cell maturation; epithelial cell proliferation; ERK1 and ERK2 cascade; hematopoietic progenitor cell differentiation; hemopoiesis; lung alveolus development; lung development; lymph vessel development; mesenchymal cell proliferation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of gene expression; negative regulation of neuron apoptotic process; ovarian follicle development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of BMP signaling pathway; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell population proliferation; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of kinase activity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of stem cell proliferation; positive regulation of vasculogenesis; post-embryonic camera-type eye morphogenesis; protein autophosphorylation; protein kinase B signaling; protein phosphorylation; regulation of bone development; regulation of cell shape; regulation of hematopoietic progenitor cell differentiation; regulation of MAPK cascade; semaphorin-plexin signaling pathway; stem cell proliferation; surfactant homeostasis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor receptor-2 signaling pathway; vascular endothelial growth factor signaling pathway; vascular wound healing; vasculogenesis","ATP binding; cadherin binding; coreceptor activity; growth factor binding; Hsp90 protein binding; identical protein binding; integrin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding; vascular endothelial growth factor receptor activity","anchoring junction; cell junction; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; early endosome; endoplasmic reticulum; endosome; external side of plasma membrane; extracellular region; Golgi apparatus; membrane; membrane raft; nucleus; plasma membrane; receptor complex; sorting endosome","Tyrosine kinase / adaptor","kinase insert domain receptor","http://www.ncbi.nlm.nih.gov/gene/?term=3791","3791","16542",null,null,null,"698293","P35968","P35918","A0A0G2K090","A0A8I3NL69","A0A5G2QBK4","F7E313","GO:0070161; GO:0030054; GO:0071944; GO:0009986; GO:0005737; GO:0031410; GO:0005769; GO:0005783; GO:0005768; GO:0009897; GO:0005576; GO:0005794; GO:0016020; GO:0045121; GO:0005634; GO:0005886; GO:0043235; GO:0097443","GO:0005524; GO:0045296; GO:0015026; GO:0019838; GO:0051879; GO:0042802; GO:0005178; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0038085; GO:0005021","GO:0001525; GO:0060837; GO:0001569; GO:0048754; GO:0055074; GO:0035584; GO:0030154; GO:0045165; GO:0016477; GO:0002042; GO:1904881; GO:0035924; GO:0035162; GO:0003157; GO:0045446; GO:0003158; GO:0002070; GO:0050673; GO:0070371; GO:0002244; GO:0030097; GO:0048286; GO:0030324; GO:0001945; GO:0010463; GO:0043066; GO:2000352; GO:0010629; GO:0043524; GO:0001541; GO:0038083; GO:0018108; GO:0016310; GO:0045766; GO:0043536; GO:0030513; GO:0030335; GO:0090050; GO:0008284; GO:0038033; GO:0010595; GO:0001938; GO:0050679; GO:0070374; GO:0051894; GO:0033674; GO:0016239; GO:0043410; GO:0002053; GO:0051901; GO:0090141; GO:0051770; GO:0014068; GO:0042327; GO:0050927; GO:0001934; GO:2000648; GO:2001214; GO:0048597; GO:0046777; GO:0043491; GO:0006468; GO:1903010; GO:0008360; GO:1901532; GO:0043408; GO:0071526; GO:0072089; GO:0043129; GO:0007169; GO:0048010; GO:0036324; GO:0038084; GO:0061042; GO:0001570","PTHR24416:SF45","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6307|UniProtKB=P35968","P00056; P00005"]
["VEGFR 2 (FLK-1)- phospho","Tyr996","KDR","230","rb",null,4,7,"n/a","n/a","n/a","n/a","# 1444",".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","VEGF signaling pathway; Angiogenesis","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","angiogenesis; blood vessel endothelial cell differentiation; branching involved in blood vessel morphogenesis; branching morphogenesis of an epithelial tube; calcium ion homeostasis; calcium-mediated signaling using intracellular calcium source; cell differentiation; cell fate commitment; cell migration; cell migration involved in sprouting angiogenesis; cellular response to hydrogen sulfide; cellular response to vascular endothelial growth factor stimulus; embryonic hemopoiesis; endocardium development; endothelial cell differentiation; endothelium development; epithelial cell maturation; epithelial cell proliferation; ERK1 and ERK2 cascade; hematopoietic progenitor cell differentiation; hemopoiesis; lung alveolus development; lung development; lymph vessel development; mesenchymal cell proliferation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of gene expression; negative regulation of neuron apoptotic process; ovarian follicle development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of BMP signaling pathway; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell population proliferation; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of kinase activity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of stem cell proliferation; positive regulation of vasculogenesis; post-embryonic camera-type eye morphogenesis; protein autophosphorylation; protein kinase B signaling; protein phosphorylation; regulation of bone development; regulation of cell shape; regulation of hematopoietic progenitor cell differentiation; regulation of MAPK cascade; semaphorin-plexin signaling pathway; stem cell proliferation; surfactant homeostasis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor receptor-2 signaling pathway; vascular endothelial growth factor signaling pathway; vascular wound healing; vasculogenesis","ATP binding; cadherin binding; coreceptor activity; growth factor binding; Hsp90 protein binding; identical protein binding; integrin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding; vascular endothelial growth factor receptor activity","anchoring junction; cell junction; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; early endosome; endoplasmic reticulum; endosome; external side of plasma membrane; extracellular region; Golgi apparatus; membrane; membrane raft; nucleus; plasma membrane; receptor complex; sorting endosome","Tyrosine kinase / adaptor","kinase insert domain receptor","http://www.ncbi.nlm.nih.gov/gene/?term=3791","3791","16542",null,null,null,"698293","P35968","P35918","A0A0G2K090","A0A8I3NL69","A0A5G2QBK4","F7E313","GO:0070161; GO:0030054; GO:0071944; GO:0009986; GO:0005737; GO:0031410; GO:0005769; GO:0005783; GO:0005768; GO:0009897; GO:0005576; GO:0005794; GO:0016020; GO:0045121; GO:0005634; GO:0005886; GO:0043235; GO:0097443","GO:0005524; GO:0045296; GO:0015026; GO:0019838; GO:0051879; GO:0042802; GO:0005178; GO:0016301; GO:0000166; GO:0005515; GO:0004672; GO:0004713; GO:0016740; GO:0004714; GO:0038085; GO:0005021","GO:0001525; GO:0060837; GO:0001569; GO:0048754; GO:0055074; GO:0035584; GO:0030154; GO:0045165; GO:0016477; GO:0002042; GO:1904881; GO:0035924; GO:0035162; GO:0003157; GO:0045446; GO:0003158; GO:0002070; GO:0050673; GO:0070371; GO:0002244; GO:0030097; GO:0048286; GO:0030324; GO:0001945; GO:0010463; GO:0043066; GO:2000352; GO:0010629; GO:0043524; GO:0001541; GO:0038083; GO:0018108; GO:0016310; GO:0045766; GO:0043536; GO:0030513; GO:0030335; GO:0090050; GO:0008284; GO:0038033; GO:0010595; GO:0001938; GO:0050679; GO:0070374; GO:0051894; GO:0033674; GO:0016239; GO:0043410; GO:0002053; GO:0051901; GO:0090141; GO:0051770; GO:0014068; GO:0042327; GO:0050927; GO:0001934; GO:2000648; GO:2001214; GO:0048597; GO:0046777; GO:0043491; GO:0006468; GO:1903010; GO:0008360; GO:1901532; GO:0043408; GO:0071526; GO:0072089; GO:0043129; GO:0007169; GO:0048010; GO:0036324; GO:0038084; GO:0061042; GO:0001570","PTHR24416:SF45","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=6307|UniProtKB=P35968","P00056; P00005"]
["Versican",null,"VCAN","400","rb",null,7,7,"n/a","n/a","n/a","n/a","# 0820",null,null,"VERSICAN CORE PROTEIN","cell adhesion; cell recognition; central nervous system development; osteoblast differentiation; skeletal system development","calcium ion binding; carbohydrate binding; extracellular matrix structural constituent conferring compression resistance; glycosaminoglycan binding; hyaluronic acid binding; protein binding","cell projection; collagen-containing extracellular matrix; endomembrane system; endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space; Golgi lumen; interphotoreceptor matrix; lysosomal lumen; membrane; photoreceptor outer segment",null,"versican","http://www.ncbi.nlm.nih.gov/gene/?term=1462","1462",null,"114122",null,null,null,"P13611","E0CZC0","Q9ERB4","A0A8I3PC36","A0A5G2QUR6","A0A5F7ZPR4","GO:0042995; GO:0062023; GO:0012505; GO:0005788; GO:0031012; GO:0005576; GO:0005615; GO:0005796; GO:0033165; GO:0043202; GO:0016020; GO:0001750","GO:0005509; GO:0030246; GO:0030021; GO:0005539; GO:0005540; GO:0005515","GO:0007155; GO:0008037; GO:0007417; GO:0001649; GO:0001501","PTHR22804:SF6","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=2464|UniProtKB=P13611"]
["Vimentin",null,"VIM","57","rb",null,1,1.1000000000000001,8,8,1,8,"# 1814",".CSP., .DEV., .DRR., .IIR., .IMUR., .OP., .OT., .TGFB., .TRASR.",null,"VIMENTIN","astrocyte development; Bergmann glial cell differentiation; cellular response to lipopolysaccharide; cellular response to muramyl dipeptide; cellular response to type II interferon; intermediate filament organization; intermediate filament-based process; lens fiber cell development; negative regulation of neuron projection development; neuron projection development; positive regulation of collagen biosynthetic process; positive regulation of gene expression; positive regulation of translation; regulation of mRNA stability; SMAD protein signal transduction","double-stranded RNA binding; identical protein binding; keratin filament binding; molecular adaptor activity; protein binding; protein domain specific binding; RNA binding; scaffold protein binding; structural constituent of cytoskeleton; structural constituent of eye lens","axon; cell leading edge; cell projection; cytoplasm; cytoskeleton; cytosol; extracellular exosome; focal adhesion; intermediate filament; intermediate filament cytoskeleton; membrane; microtubule organizing center; neuron projection; nuclear matrix; nucleus; peroxisome; phagocytic vesicle; plasma membrane; polysome; ribonucleoprotein complex","Cytoskeletal signaling","vimentin","http://www.ncbi.nlm.nih.gov/gene/?term=7431","7431","22352",null,null,"100522394","705289","P08670","P20152","G3V8C3","A0A8I3NNR9","P02543","G7N1N6","GO:0030424; GO:0031252; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005925; GO:0005882; GO:0045111; GO:0016020; GO:0005815; GO:0043005; GO:0016363; GO:0005634; GO:0005777; GO:0045335; GO:0005886; GO:0005844; GO:1990904","GO:0003725; GO:0042802; GO:1990254; GO:0060090; GO:0005515; GO:0019904; GO:0003723; GO:0097110; GO:0005200; GO:0005212","GO:0014002; GO:0060020; GO:0071222; GO:0071225; GO:0071346; GO:0045109; GO:0045103; GO:0070307; GO:0010977; GO:0031175; GO:0032967; GO:0010628; GO:0045727; GO:0043488; GO:0060395","PTHR45652:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12692|UniProtKB=P08670"]
["Vimentin - phospho","Ser56","VIM","57","rb",null,2,1,1,8,8,8,"# 1538",".CSP., .DEV., .DRR., .IIR., .IMUR., .OP., .OT., .TGFB., .TRASR.",null,"VIMENTIN","astrocyte development; Bergmann glial cell differentiation; cellular response to lipopolysaccharide; cellular response to muramyl dipeptide; cellular response to type II interferon; intermediate filament organization; intermediate filament-based process; lens fiber cell development; negative regulation of neuron projection development; neuron projection development; positive regulation of collagen biosynthetic process; positive regulation of gene expression; positive regulation of translation; regulation of mRNA stability; SMAD protein signal transduction","double-stranded RNA binding; identical protein binding; keratin filament binding; molecular adaptor activity; protein binding; protein domain specific binding; RNA binding; scaffold protein binding; structural constituent of cytoskeleton; structural constituent of eye lens","axon; cell leading edge; cell projection; cytoplasm; cytoskeleton; cytosol; extracellular exosome; focal adhesion; intermediate filament; intermediate filament cytoskeleton; membrane; microtubule organizing center; neuron projection; nuclear matrix; nucleus; peroxisome; phagocytic vesicle; plasma membrane; polysome; ribonucleoprotein complex","Cytoskeletal signaling","vimentin","http://www.ncbi.nlm.nih.gov/gene/?term=7431","7431","22352",null,null,"100522394","705289","P08670","P20152","G3V8C3","A0A8I3NNR9","P02543","G7N1N6","GO:0030424; GO:0031252; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005925; GO:0005882; GO:0045111; GO:0016020; GO:0005815; GO:0043005; GO:0016363; GO:0005634; GO:0005777; GO:0045335; GO:0005886; GO:0005844; GO:1990904","GO:0003725; GO:0042802; GO:1990254; GO:0060090; GO:0005515; GO:0019904; GO:0003723; GO:0097110; GO:0005200; GO:0005212","GO:0014002; GO:0060020; GO:0071222; GO:0071225; GO:0071346; GO:0045109; GO:0045103; GO:0070307; GO:0010977; GO:0031175; GO:0032967; GO:0010628; GO:0045727; GO:0043488; GO:0060395","PTHR45652:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12692|UniProtKB=P08670"]
["Vimentin - phospho","Ser83","VIM","57","rb",null,2,4,8,8,8,8,"# 1505",".CSP., .DEV., .DRR., .IIR., .IMUR., .OP., .OT., .TGFB., .TRASR.",null,"VIMENTIN","astrocyte development; Bergmann glial cell differentiation; cellular response to lipopolysaccharide; cellular response to muramyl dipeptide; cellular response to type II interferon; intermediate filament organization; intermediate filament-based process; lens fiber cell development; negative regulation of neuron projection development; neuron projection development; positive regulation of collagen biosynthetic process; positive regulation of gene expression; positive regulation of translation; regulation of mRNA stability; SMAD protein signal transduction","double-stranded RNA binding; identical protein binding; keratin filament binding; molecular adaptor activity; protein binding; protein domain specific binding; RNA binding; scaffold protein binding; structural constituent of cytoskeleton; structural constituent of eye lens","axon; cell leading edge; cell projection; cytoplasm; cytoskeleton; cytosol; extracellular exosome; focal adhesion; intermediate filament; intermediate filament cytoskeleton; membrane; microtubule organizing center; neuron projection; nuclear matrix; nucleus; peroxisome; phagocytic vesicle; plasma membrane; polysome; ribonucleoprotein complex","Cytoskeletal signaling","vimentin","http://www.ncbi.nlm.nih.gov/gene/?term=7431","7431","22352",null,null,"100522394","705289","P08670","P20152","G3V8C3","A0A8I3NNR9","P02543","G7N1N6","GO:0030424; GO:0031252; GO:0042995; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005925; GO:0005882; GO:0045111; GO:0016020; GO:0005815; GO:0043005; GO:0016363; GO:0005634; GO:0005777; GO:0045335; GO:0005886; GO:0005844; GO:1990904","GO:0003725; GO:0042802; GO:1990254; GO:0060090; GO:0005515; GO:0019904; GO:0003723; GO:0097110; GO:0005200; GO:0005212","GO:0014002; GO:0060020; GO:0071222; GO:0071225; GO:0071346; GO:0045109; GO:0045103; GO:0070307; GO:0010977; GO:0031175; GO:0032967; GO:0010628; GO:0045727; GO:0043488; GO:0060395","PTHR45652:SF5","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12692|UniProtKB=P08670"]
["Vinculin",null,"VCL","124","rb",null,1,1,"n/a","n/a","n/a","n/a","# 2215",".CSP., .INT., .MIG., .OP., .OPA., .OT., .PLAT.","Gonadotropin releasing hormone receptor pathway; Integrin signalling pathway","VINCULIN","adherens junction assembly; apical junction assembly; axon extension; cell adhesion; cell-matrix adhesion; epithelial cell-cell adhesion; lamellipodium assembly; maintenance of blood-brain barrier; morphogenesis of an epithelium; negative regulation of cell migration; platelet aggregation; protein localization to cell surface; regulation of cell migration; regulation of establishment of endothelial barrier; regulation of focal adhesion assembly; regulation of protein localization to adherens junction","actin binding; alpha-catenin binding; beta-catenin binding; cadherin binding; dystroglycan binding; protein binding; structural molecule activity; ubiquitin protein ligase binding","actin cytoskeleton; adherens junction; anchoring junction; cell-cell contact zone; cell-cell junction; cell-substrate junction; costamere; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular region; extracellular vesicle; fascia adherens; ficolin-1-rich granule lumen; focal adhesion; membrane; plasma membrane; podosome; podosome ring; protein-containing complex; sarcolemma; secretory granule lumen; specific granule lumen",null,"vinculin","http://www.ncbi.nlm.nih.gov/gene/?term=7414","7414","22330","305679",null,"396974",null,"P18206","Q64727","P85972","A0A8P0SJT6","P26234","A0A5F7ZE05","GO:0015629; GO:0005912; GO:0070161; GO:0044291; GO:0005911; GO:0030055; GO:0043034; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005576; GO:1903561; GO:0005916; GO:1904813; GO:0005925; GO:0016020; GO:0005886; GO:0002102; GO:0061826; GO:0032991; GO:0042383; GO:0034774; GO:0035580","GO:0003779; GO:0045294; GO:0008013; GO:0045296; GO:0002162; GO:0005515; GO:0005198; GO:0031625","GO:0034333; GO:0043297; GO:0048675; GO:0007155; GO:0007160; GO:0090136; GO:0030032; GO:0035633; GO:0002009; GO:0030336; GO:0070527; GO:0034394; GO:0030334; GO:1903140; GO:0051893; GO:1904702","PTHR46180:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12665|UniProtKB=P18206","P06664; P00034"]
["VISTA",null,"VSIR","65-45","rb",null,1,8,"n/a","n/a","n/a","n/a","# 2812",".CSP., .IMU., .IMUF., .IMUR., .MIG., .OP., .OT., .TCD., .TCR., .TMAT., .TRASR.",null,"V-TYPE IMMUNOGLOBULIN DOMAIN-CONTAINING SUPPRESSOR OF T-CELL ACTIVATION","negative regulation of alpha-beta T cell activation; negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of CD8-positive, alpha-beta T cell proliferation; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of tumor necrosis factor production; negative regulation of type II interferon production; positive regulation of cell migration; positive regulation of collagen catabolic process; positive regulation of endopeptidase activity; positive regulation of gene expression; positive regulation of regulatory T cell differentiation; regulation of immune response; zymogen activation","endopeptidase activator activity; enzyme binding; identical protein binding; protein binding","membrane; plasma membrane",null,"V-set immunoregulatory receptor","http://www.ncbi.nlm.nih.gov/gene/?term=64115","64115","74048","690899",null,null,"709595","Q9H7M9","Q9D659","G3V9P3","A0A8I3MV11","A0A8W4FCG3","F7F6S6","GO:0016020; GO:0005886","GO:0061133; GO:0019899; GO:0042802; GO:0005515","GO:0046636; GO:2000562; GO:2000565; GO:0032693; GO:0032700; GO:0032720; GO:0032689; GO:0030335; GO:0120158; GO:0010950; GO:0010628; GO:0045591; GO:0050776; GO:0031638","PTHR44819:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=30085|UniProtKB=Q9H7M9"]
["WFS1",null,"WFS1","100","rb",null,2,4,"n/a","n/a","n/a","n/a","# 2204",".APO., .CD., .CSP., .OP., .OPA., .OT., .ST., .TRASR., .UBI.",null,"WOLFRAMIN","calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum unfolded protein response; ER overload response; glucose homeostasis; kidney development; negative regulation of apoptotic process; negative regulation of ATF6-mediated unfolded protein response; negative regulation of DNA-binding transcription factor activity; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of neuron apoptotic process; negative regulation of programmed cell death; negative regulation of response to endoplasmic reticulum stress; negative regulation of transcription by RNA polymerase II; negative regulation of type B pancreatic cell apoptotic process; nervous system process; olfactory behavior; pancreas development; positive regulation of calcium ion transport; positive regulation of growth; positive regulation of protein metabolic process; positive regulation of protein ubiquitination; protein maturation by protein folding; protein stabilization; renal water homeostasis; response to endoplasmic reticulum stress; sensory perception of sound; ubiquitin-dependent ERAD pathway; visual perception","ATPase binding; calcium-dependent protein binding; calmodulin binding; DNA-binding transcription factor binding; proteasome binding; protein binding; ubiquitin protein ligase binding","cytoplasmic vesicle; dendrite; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; membrane; secretory granule; synaptic vesicle membrane; transport vesicle",null,"wolframin ER transmembrane glycoprotein","http://www.ncbi.nlm.nih.gov/gene/?term=7466","7466","22393",null,null,null,null,"O76024","P56695","A0A8I6A452","A0A8I3NG62",null,"F6Z3A4","GO:0031410; GO:0030425; GO:0005783; GO:0005788; GO:0005789; GO:0016020; GO:0030141; GO:0030672; GO:0030133","GO:0051117; GO:0048306; GO:0005516; GO:0140297; GO:0070628; GO:0005515; GO:0031625","GO:0055074; GO:0032469; GO:0030968; GO:0006983; GO:0042593; GO:0001822; GO:0043066; GO:1903892; GO:0043433; GO:1902236; GO:0043524; GO:0043069; GO:1903573; GO:0000122; GO:2000675; GO:0050877; GO:0042048; GO:0031016; GO:0051928; GO:0045927; GO:0051247; GO:0031398; GO:0022417; GO:0050821; GO:0003091; GO:0034976; GO:0007605; GO:0030433; GO:0007601","PTHR13098:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12762|UniProtKB=O76024"]
["WIPI-1 (WIPI-49)",null,"WIPI1","49","ms",null,6,7,"n/a","n/a","n/a","n/a","# 0607",".ALZ., .APH., .CD., .CSP., .DI., .HUNT., .OP.",null,"WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 1","autophagosome assembly; autophagy; autophagy of mitochondrion; autophagy of nucleus; cellular response to starvation; positive regulation of autophagosome assembly; protein lipidation; protein localization to phagophore assembly site; vesicle targeting, trans-Golgi to endosome","lipid binding; nuclear androgen receptor binding; nuclear estrogen receptor binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; protein binding; signaling receptor binding","autophagosome membrane; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endosome; endosome membrane; extrinsic component of membrane; Golgi apparatus; Golgi membrane; membrane; phagophore assembly site; phagophore assembly site membrane; trans-Golgi network",null,"WD repeat domain, phosphoinositide interacting 1","http://www.ncbi.nlm.nih.gov/gene/?term=55062","55062","52639",null,"490899",null,null,"Q5MNZ9","Q8R3E3","A0A8I5ZTL1","A0A8I3Q041","A0A287BP92","F7F2W8","GO:0000421; GO:0030136; GO:0005737; GO:0031410; GO:0005856; GO:0005829; GO:0005768; GO:0010008; GO:0019898; GO:0005794; GO:0000139; GO:0016020; GO:0000407; GO:0034045; GO:0005802","GO:0008289; GO:0050681; GO:0030331; GO:0080025; GO:0032266; GO:0005515; GO:0005102","GO:0000045; GO:0006914; GO:0000422; GO:0044804; GO:0009267; GO:2000786; GO:0006497; GO:0034497; GO:0048203","PTHR11227:SF23","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=25471|UniProtKB=Q5MNZ9"]
["WISP2",null,"CCN5","27","ms",null,7,7,"n/a","n/a","n/a","n/a","# 1082",".CSP., .OPA., .ST.",null,"CCN FAMILY MEMBER 5","cell adhesion; cell-cell signaling; negative regulation of cell death; signal transduction","heparin binding; integrin binding; protein binding","extracellular matrix; extracellular region; extracellular space; nucleus",null,"cellular communication network factor 5","http://www.ncbi.nlm.nih.gov/gene/?term=8839","8839","22403",null,"610928",null,null,"O76076","A2AHD1","A0A8I6AR16","A0A8P0NBL7",null,"A0A1D5Q1V5","GO:0031012; GO:0005576; GO:0005615; GO:0005634","GO:0008201; GO:0005178; GO:0005515","GO:0007155; GO:0007267; GO:0060548; GO:0007165","PTHR11348:SF22","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12770|UniProtKB=O76076"]
["Wnt3A",null,"WNT3A","40","rb",null,2,1,1,1,2,2,"# 0741",".ALZ., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .DEV., .DI., .HIPPO., .IMUF., .MTOR., .OP., .OPA., .OT., .PLAT., .RTK., .ST., .TRASR., .WNT.","Alzheimer disease-presenilin pathway; Cadherin signaling pathway; Wnt signaling pathway","PROTEIN WNT-3A","anterior/posterior pattern specification; axis elongation involved in somitogenesis; axon guidance; axonogenesis; B cell proliferation; calcium ion transmembrane transport via low voltage-gated calcium channel; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; cardiac muscle cell fate commitment; cell fate commitment; cell population proliferation; cell proliferation in forebrain; cell proliferation in midbrain; cellular response to retinoic acid; COP9 signalosome assembly; determination of left/right symmetry; dorsal/ventral neural tube patterning; extracellular matrix organization; fat cell differentiation; heart looping; hemopoiesis; hippocampus development; in utero embryonic development; inner ear morphogenesis; mammary gland development; mesoderm development; midbrain development; modulation of chemical synaptic transmission; myoblast differentiation; negative regulation of axon extension involved in axon guidance; negative regulation of dopaminergic neuron differentiation; negative regulation of fat cell differentiation; negative regulation of heart induction by canonical Wnt signaling pathway; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of neuron projection development; neurogenesis; neuron differentiation; osteoblast differentiation; paraxial mesodermal cell fate commitment; platelet activation; platelet aggregation; positive regulation of B cell proliferation; positive regulation of canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation; positive regulation of cardiac muscle cell differentiation; positive regulation of cell population proliferation; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of collateral sprouting in absence of injury; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cytokine production; positive regulation of dermatome development; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of hepatocyte proliferation; positive regulation of mesodermal cell fate specification; positive regulation of neural precursor cell proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; positive regulation of protein tyrosine kinase activity; positive regulation of receptor internalization; positive regulation of skeletal muscle tissue development; positive regulation of transcription by RNA polymerase II; post-anal tail morphogenesis; presynapse assembly; protein localization; regulation of axonogenesis; regulation of cell differentiation; regulation of gene expression; regulation of microtubule cytoskeleton organization; regulation of postsynapse to nucleus signaling pathway; regulation of presynapse assembly; regulation of RNA biosynthetic process; regulation of synapse organization; secondary palate development; skeletal muscle cell differentiation; somatic stem cell division; somitogenesis; spinal cord association neuron differentiation; synaptic vesicle recycling; transcription by RNA polymerase II; Wnt signaling pathway; Wnt signaling pathway involved in forebrain neuroblast division; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation","co-receptor binding; cytokine activity; frizzled binding; identical protein binding; protein binding; protein domain specific binding; receptor ligand activity; signaling receptor binding; transcription coactivator activity","cell surface; early endosome membrane; endocytic vesicle membrane; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; glutamatergic synapse; Golgi lumen; plasma membrane; presynapse; synapse; Wnt-Frizzled-LRP5/6 complex","Wnt signaling","Wnt family member 3A","http://www.ncbi.nlm.nih.gov/gene/?term=89780","89780","22416","303181",null,null,null,"P56704","P27467","A0A8I6ADM6","A0A8I3MWK0","I3LBV3",null,"GO:0009986; GO:0031901; GO:0030666; GO:0005788; GO:0070062; GO:0005576; GO:0005615; GO:0098978; GO:0005796; GO:0005886; GO:0098793; GO:0045202; GO:1990851","GO:0039706; GO:0005125; GO:0005109; GO:0042802; GO:0005515; GO:0019904; GO:0048018; GO:0005102; GO:0003713","GO:0009952; GO:0090245; GO:0007411; GO:0007409; GO:0042100; GO:0090676; GO:0060070; GO:0061317; GO:0060923; GO:0045165; GO:0008283; GO:0021846; GO:0033278; GO:0071300; GO:0010387; GO:0007368; GO:0021904; GO:0030198; GO:0045444; GO:0001947; GO:0030097; GO:0021766; GO:0001701; GO:0042472; GO:0030879; GO:0007498; GO:0030901; GO:0050804; GO:0045445; GO:0048843; GO:1904339; GO:0045599; GO:0003136; GO:0050768; GO:1901215; GO:0010977; GO:0022008; GO:0030182; GO:0001649; GO:0048343; GO:0030168; GO:0070527; GO:0030890; GO:0090263; GO:2000081; GO:2000727; GO:0008284; GO:2000049; GO:0048697; GO:0043280; GO:0001819; GO:0061184; GO:0051091; GO:0045893; GO:0010628; GO:2000347; GO:0048337; GO:2000179; GO:0033138; GO:0032092; GO:0045860; GO:1903078; GO:0001934; GO:0061098; GO:0002092; GO:0048643; GO:0045944; GO:0036342; GO:0099054; GO:0008104; GO:0050770; GO:0045595; GO:0010468; GO:0070507; GO:1905539; GO:1905606; GO:2001141; GO:0050807; GO:0062009; GO:0035914; GO:0048103; GO:0001756; GO:0021527; GO:0036465; GO:0006366; GO:0016055; GO:0021874; GO:1904953","PTHR12027:SF88","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=15983|UniProtKB=P56704","P00004; P00012; P00057"]
["WT1 /PAR4",null,"PAWR","37","rb",null,7,2,"n/a","n/a","n/a","n/a","# 2115",".APO., .BCR., .CCP., .CD., .CP., .CSP., .IMUF., .OP., .OT., .TCR., .TRASR.",null,"PRKC APOPTOSIS WT1 REGULATOR PROTEIN","actin filament bundle assembly; apoptotic process; apoptotic signaling pathway; negative regulation of B cell proliferation; negative regulation of fibroblast proliferation; negative regulation of gene expression; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of amyloid precursor protein biosynthetic process; positive regulation of apoptotic process; positive regulation of cellular senescence; positive regulation of gene expression; positive regulation of hydrogen peroxide-mediated programmed cell death","actin binding; enzyme binding; leucine zipper domain binding; protein binding; transcription corepressor activity","actin cytoskeleton; actin filament; chromatin; cytoplasm; nucleus; plasma membrane",null,"pro-apoptotic WT1 regulator","http://www.ncbi.nlm.nih.gov/gene/?term=5074","5074","114774",null,null,null,null,"Q96IZ0","Q925B0","A0A8I6A135",null,null,"F6WI71","GO:0015629; GO:0005884; GO:0000785; GO:0005737; GO:0005634; GO:0005886","GO:0003779; GO:0019899; GO:0043522; GO:0005515; GO:0003714","GO:0051017; GO:0006915; GO:0097190; GO:0030889; GO:0048147; GO:0010629; GO:0042130; GO:0050860; GO:0000122; GO:0042986; GO:0043065; GO:2000774; GO:0010628; GO:1901300","PTHR15093:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8614|UniProtKB=Q96IZ0"]
["XBP1 (TREB5)",null,"XBP1","29","gt",null,6,2,"n/a","n/a","n/a","n/a","# 0730",".ALZ., .ANG., .APO., .BCR., .CANCER., .CCP., .CD., .CP., .CSP., .DI., .IMU., .IMUF., .IMUR., .INS., .MIG., .OP., .OPA., .OT., .SREME., .ST., .TCD., .TCR., .TMAT., .TRASR.",null,"X-BOX-BINDING PROTEIN 1","adipose tissue development; angiogenesis; apoptotic process; ATF6-mediated unfolded protein response; autophagy; cell differentiation; cellular response to amino acid stimulus; cellular response to fructose stimulus; cellular response to glucose starvation; cellular response to glucose stimulus; cellular response to insulin stimulus; cellular response to interleukin-4; cellular response to lipopolysaccharide; cellular response to nutrient; cellular response to peptide hormone stimulus; cellular triglyceride homeostasis; cholesterol homeostasis; endoplasmic reticulum unfolded protein response; ERAD pathway; fatty acid biosynthetic process; fatty acid homeostasis; immune response; IRE1-mediated unfolded protein response; lipid metabolic process; liver development; muscle organ development; negative regulation of apoptotic process; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of myotube differentiation; neuron development; positive regulation of angiogenesis; positive regulation of B cell differentiation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of fat cell differentiation; positive regulation of hepatocyte proliferation; positive regulation of immunoglobulin production; positive regulation of interleukin-6 production; positive regulation of lactation; positive regulation of MHC class II biosynthetic process; positive regulation of plasma cell differentiation; positive regulation of T cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; positive regulation of vascular wound healing; protein transport; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to insulin-like growth factor stimulus; response to unfolded protein; sterol homeostasis; transcription by RNA polymerase II; ubiquitin-dependent protein catabolic process","cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding","cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex","Translational control","X-box binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=7494","7494","22433","289754",null,null,"713863","P17861","O35426","A0A140TAA7","A0A8I3QMJ2","A0A287AY46","F7EKN6","GO:0005737; GO:0005783; GO:0005789; GO:0016020; GO:0005654; GO:0005634; GO:0090575","GO:0000987; GO:0003677; GO:0003700; GO:0000981; GO:0042802; GO:0005515; GO:0046982; GO:0000978; GO:0000977; GO:1990837","GO:0060612; GO:0001525; GO:0006915; GO:0036500; GO:0006914; GO:0030154; GO:0071230; GO:0071332; GO:0042149; GO:0071333; GO:0032869; GO:0071353; GO:0071222; GO:0031670; GO:0071375; GO:0035356; GO:0042632; GO:0030968; GO:0036503; GO:0006633; GO:0055089; GO:0006955; GO:0036498; GO:0006629; GO:0001889; GO:0007517; GO:0043066; GO:1902236; GO:0010832; GO:0048666; GO:0045766; GO:0045579; GO:0030335; GO:0008284; GO:1900103; GO:0045600; GO:2000347; GO:0002639; GO:0032755; GO:1903489; GO:0045348; GO:1900100; GO:0045582; GO:0045944; GO:0006990; GO:0035470; GO:0015031; GO:0006355; GO:0006357; GO:1990418; GO:0006986; GO:0055092; GO:0006366; GO:0006511","PTHR46542:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12801|UniProtKB=P17861"]
["XLF",null,"NHEJ1","39","rb",null,2,1,1,2,2,2.1,"# 1369",".BCR., .CD., .CSP., .DDR., .DREP., .IMUF., .TCR.",null,"NON-HOMOLOGOUS END-JOINING FACTOR 1","B cell differentiation; cellular response to DNA damage stimulus; central nervous system development; DNA ligation involved in DNA repair; DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; immunoglobulin V(D)J recombination; positive regulation of ligase activity; response to ionizing radiation; T cell differentiation","DNA binding; DNA end binding; DNA polymerase binding; protein binding","chromosome; DNA ligase IV complex; fibrillar center; nonhomologous end joining complex; nucleoplasm; nucleus; site of double-strand break","DNA damage","non-homologous end joining factor 1","http://www.ncbi.nlm.nih.gov/gene/?term=79840","79840","75570","363251",null,null,"701542","Q9H9Q4","Q3KNJ2","A0A8I5Y7R3","A0A8P0STU4","A0A286ZPZ6","E5FGE3","GO:0005694; GO:0032807; GO:0001650; GO:0070419; GO:0005654; GO:0005634; GO:0035861","GO:0003677; GO:0045027; GO:0070182; GO:0005515","GO:0030183; GO:0006974; GO:0007417; GO:0051103; GO:0006281; GO:0006302; GO:0006303; GO:0033152; GO:0051351; GO:0010212; GO:0030217","PTHR32235:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=25737|UniProtKB=Q9H9Q4"]
["YAP",null,"YAP1","75-65","rb",null,1,2,2.1,8,8,8,"# 1605",".APO., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .DRR., .HIPPO., .IMUF., .INFM., .NOTCH., .OP., .OPA., .OT., .ST., .TRASR., .WNT.",null,"TRANSCRIPTIONAL COACTIVATOR YAP1","blastocyst development; bud elongation involved in lung branching; canonical Wnt signaling pathway; cardiac muscle tissue regeneration; cell morphogenesis; cell population proliferation; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to retinoic acid; contact inhibition; embryonic heart tube morphogenesis; enterocyte differentiation; epithelial cell proliferation; extrinsic apoptotic signaling pathway; glandular epithelial cell differentiation; heart process; hippo signaling; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; intestinal epithelial cell differentiation; keratinocyte differentiation; lateral mesoderm development; lung epithelial cell differentiation; negative regulation of cilium assembly; negative regulation of epithelial cell apoptotic process; negative regulation of epithelial cell differentiation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; notochord development; organ growth; paraxial mesoderm development; positive regulation of canonical Wnt signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of Notch signaling pathway; positive regulation of organ growth; positive regulation of osteoblast differentiation; positive regulation of protein localization to nucleus; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; protein-containing complex assembly; regulation of canonical Wnt signaling pathway; regulation of cell population proliferation; regulation of gene expression; regulation of keratinocyte proliferation; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of stem cell proliferation; response to progesterone; somatic stem cell population maintenance; tissue homeostasis; trophectodermal cell differentiation; vasculogenesis; wound healing","chromatin binding; DNA-binding transcription factor binding; molecular function inhibitor activity; proline-rich region binding; protein binding; protein C-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coactivator activity; transcription corepressor activity","cell junction; cytoplasm; cytosol; female germ cell nucleus; membrane; nucleoplasm; nucleus; TEAD-YAP complex; transcription regulator complex","Hippo signaling","Yes1 associated transcriptional regulator","http://www.ncbi.nlm.nih.gov/gene/?term=10413","10413","22601","363014",null,null,"704382","P46937","P46938","Q2EJA0","A0A8I3MI73",null,"A0A1D5QLM0","GO:0030054; GO:0005737; GO:0005829; GO:0001674; GO:0016020; GO:0005654; GO:0005634; GO:0140552; GO:0005667","GO:0003682; GO:0140297; GO:0140678; GO:0070064; GO:0005515; GO:0008022; GO:0000978; GO:0000976; GO:0003713; GO:0003714","GO:0001824; GO:0060449; GO:0060070; GO:0061026; GO:0000902; GO:0008283; GO:0006974; GO:0071480; GO:0071300; GO:0060242; GO:0003143; GO:1903703; GO:0050673; GO:0097191; GO:0002067; GO:0003015; GO:0035329; GO:0070102; GO:0060576; GO:0060575; GO:0030216; GO:0048368; GO:0060487; GO:1902018; GO:1904036; GO:0030857; GO:2001237; GO:0045599; GO:0010629; GO:2000737; GO:0000122; GO:0030903; GO:0035265; GO:0048339; GO:0090263; GO:0060045; GO:0030307; GO:0008284; GO:0045893; GO:0050679; GO:0010628; GO:0033148; GO:0045747; GO:0046622; GO:0045669; GO:1900182; GO:1902459; GO:0045944; GO:0050847; GO:0065003; GO:0060828; GO:0042127; GO:0010468; GO:0010837; GO:0072307; GO:0050767; GO:0072091; GO:0032570; GO:0035019; GO:0001894; GO:0001829; GO:0001570; GO:0042060","PTHR17616:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16262|UniProtKB=P46937"]
["YAP - phospho","Ser127","YAP1","75-65","rb",null,2,2,6,6,7,7,"# 1260",".APO., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .DRR., .HIPPO., .IMUF., .INFM., .NOTCH., .OP., .OPA., .OT., .ST., .TRASR., .WNT.",null,"TRANSCRIPTIONAL COACTIVATOR YAP1","blastocyst development; bud elongation involved in lung branching; canonical Wnt signaling pathway; cardiac muscle tissue regeneration; cell morphogenesis; cell population proliferation; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to retinoic acid; contact inhibition; embryonic heart tube morphogenesis; enterocyte differentiation; epithelial cell proliferation; extrinsic apoptotic signaling pathway; glandular epithelial cell differentiation; heart process; hippo signaling; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; intestinal epithelial cell differentiation; keratinocyte differentiation; lateral mesoderm development; lung epithelial cell differentiation; negative regulation of cilium assembly; negative regulation of epithelial cell apoptotic process; negative regulation of epithelial cell differentiation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; notochord development; organ growth; paraxial mesoderm development; positive regulation of canonical Wnt signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of Notch signaling pathway; positive regulation of organ growth; positive regulation of osteoblast differentiation; positive regulation of protein localization to nucleus; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; protein-containing complex assembly; regulation of canonical Wnt signaling pathway; regulation of cell population proliferation; regulation of gene expression; regulation of keratinocyte proliferation; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of stem cell proliferation; response to progesterone; somatic stem cell population maintenance; tissue homeostasis; trophectodermal cell differentiation; vasculogenesis; wound healing","chromatin binding; DNA-binding transcription factor binding; molecular function inhibitor activity; proline-rich region binding; protein binding; protein C-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coactivator activity; transcription corepressor activity","cell junction; cytoplasm; cytosol; female germ cell nucleus; membrane; nucleoplasm; nucleus; TEAD-YAP complex; transcription regulator complex","Hippo signaling","Yes1 associated transcriptional regulator","http://www.ncbi.nlm.nih.gov/gene/?term=10413","10413","22601","363014",null,null,"704382","P46937","P46938","Q2EJA0","A0A8I3MI73",null,"A0A1D5QLM0","GO:0030054; GO:0005737; GO:0005829; GO:0001674; GO:0016020; GO:0005654; GO:0005634; GO:0140552; GO:0005667","GO:0003682; GO:0140297; GO:0140678; GO:0070064; GO:0005515; GO:0008022; GO:0000978; GO:0000976; GO:0003713; GO:0003714","GO:0001824; GO:0060449; GO:0060070; GO:0061026; GO:0000902; GO:0008283; GO:0006974; GO:0071480; GO:0071300; GO:0060242; GO:0003143; GO:1903703; GO:0050673; GO:0097191; GO:0002067; GO:0003015; GO:0035329; GO:0070102; GO:0060576; GO:0060575; GO:0030216; GO:0048368; GO:0060487; GO:1902018; GO:1904036; GO:0030857; GO:2001237; GO:0045599; GO:0010629; GO:2000737; GO:0000122; GO:0030903; GO:0035265; GO:0048339; GO:0090263; GO:0060045; GO:0030307; GO:0008284; GO:0045893; GO:0050679; GO:0010628; GO:0033148; GO:0045747; GO:0046622; GO:0045669; GO:1900182; GO:1902459; GO:0045944; GO:0050847; GO:0065003; GO:0060828; GO:0042127; GO:0010468; GO:0010837; GO:0072307; GO:0050767; GO:0072091; GO:0032570; GO:0035019; GO:0001894; GO:0001829; GO:0001570; GO:0042060","PTHR17616:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16262|UniProtKB=P46937"]
["YAP - phospho","Ser397","YAP1","75","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1761",".APO., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .DRR., .HIPPO., .IMUF., .INFM., .NOTCH., .OP., .OPA., .OT., .ST., .TRASR., .WNT.",null,"TRANSCRIPTIONAL COACTIVATOR YAP1","blastocyst development; bud elongation involved in lung branching; canonical Wnt signaling pathway; cardiac muscle tissue regeneration; cell morphogenesis; cell population proliferation; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to retinoic acid; contact inhibition; embryonic heart tube morphogenesis; enterocyte differentiation; epithelial cell proliferation; extrinsic apoptotic signaling pathway; glandular epithelial cell differentiation; heart process; hippo signaling; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; intestinal epithelial cell differentiation; keratinocyte differentiation; lateral mesoderm development; lung epithelial cell differentiation; negative regulation of cilium assembly; negative regulation of epithelial cell apoptotic process; negative regulation of epithelial cell differentiation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; notochord development; organ growth; paraxial mesoderm development; positive regulation of canonical Wnt signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of Notch signaling pathway; positive regulation of organ growth; positive regulation of osteoblast differentiation; positive regulation of protein localization to nucleus; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; protein-containing complex assembly; regulation of canonical Wnt signaling pathway; regulation of cell population proliferation; regulation of gene expression; regulation of keratinocyte proliferation; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of stem cell proliferation; response to progesterone; somatic stem cell population maintenance; tissue homeostasis; trophectodermal cell differentiation; vasculogenesis; wound healing","chromatin binding; DNA-binding transcription factor binding; molecular function inhibitor activity; proline-rich region binding; protein binding; protein C-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coactivator activity; transcription corepressor activity","cell junction; cytoplasm; cytosol; female germ cell nucleus; membrane; nucleoplasm; nucleus; TEAD-YAP complex; transcription regulator complex",null,"Yes1 associated transcriptional regulator","http://www.ncbi.nlm.nih.gov/gene/?term=10413","10413","22601","363014",null,null,"704382","P46937","P46938","Q2EJA0","A0A8I3MI73",null,"A0A1D5QLM0","GO:0030054; GO:0005737; GO:0005829; GO:0001674; GO:0016020; GO:0005654; GO:0005634; GO:0140552; GO:0005667","GO:0003682; GO:0140297; GO:0140678; GO:0070064; GO:0005515; GO:0008022; GO:0000978; GO:0000976; GO:0003713; GO:0003714","GO:0001824; GO:0060449; GO:0060070; GO:0061026; GO:0000902; GO:0008283; GO:0006974; GO:0071480; GO:0071300; GO:0060242; GO:0003143; GO:1903703; GO:0050673; GO:0097191; GO:0002067; GO:0003015; GO:0035329; GO:0070102; GO:0060576; GO:0060575; GO:0030216; GO:0048368; GO:0060487; GO:1902018; GO:1904036; GO:0030857; GO:2001237; GO:0045599; GO:0010629; GO:2000737; GO:0000122; GO:0030903; GO:0035265; GO:0048339; GO:0090263; GO:0060045; GO:0030307; GO:0008284; GO:0045893; GO:0050679; GO:0010628; GO:0033148; GO:0045747; GO:0046622; GO:0045669; GO:1900182; GO:1902459; GO:0045944; GO:0050847; GO:0065003; GO:0060828; GO:0042127; GO:0010468; GO:0010837; GO:0072307; GO:0050767; GO:0072091; GO:0032570; GO:0035019; GO:0001894; GO:0001829; GO:0001570; GO:0042060","PTHR17616:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16262|UniProtKB=P46937"]
["YAP/TAZ",null,"YAP1","70, 50","rb",null,1,1.1000000000000001,1,8,8,8,"# 1894",".APO., .CCP., .CD., .CP., .CSP., .DDR., .DEV., .DRR., .HIPPO., .IMUF., .INFM., .NOTCH., .OP., .OPA., .OT., .ST., .TRASR., .WNT.",null,"TRANSCRIPTIONAL COACTIVATOR YAP1","blastocyst development; bud elongation involved in lung branching; canonical Wnt signaling pathway; cardiac muscle tissue regeneration; cell morphogenesis; cell population proliferation; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to retinoic acid; contact inhibition; embryonic heart tube morphogenesis; enterocyte differentiation; epithelial cell proliferation; extrinsic apoptotic signaling pathway; glandular epithelial cell differentiation; heart process; hippo signaling; interleukin-6-mediated signaling pathway; intestinal epithelial cell development; intestinal epithelial cell differentiation; keratinocyte differentiation; lateral mesoderm development; lung epithelial cell differentiation; negative regulation of cilium assembly; negative regulation of epithelial cell apoptotic process; negative regulation of epithelial cell differentiation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fat cell differentiation; negative regulation of gene expression; negative regulation of stem cell differentiation; negative regulation of transcription by RNA polymerase II; notochord development; organ growth; paraxial mesoderm development; positive regulation of canonical Wnt signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of Notch signaling pathway; positive regulation of organ growth; positive regulation of osteoblast differentiation; positive regulation of protein localization to nucleus; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; protein-containing complex assembly; regulation of canonical Wnt signaling pathway; regulation of cell population proliferation; regulation of gene expression; regulation of keratinocyte proliferation; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of stem cell proliferation; response to progesterone; somatic stem cell population maintenance; tissue homeostasis; trophectodermal cell differentiation; vasculogenesis; wound healing","chromatin binding; DNA-binding transcription factor binding; molecular function inhibitor activity; proline-rich region binding; protein binding; protein C-terminus binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coactivator activity; transcription corepressor activity","cell junction; cytoplasm; cytosol; female germ cell nucleus; membrane; nucleoplasm; nucleus; TEAD-YAP complex; transcription regulator complex",null,"Yes1 associated transcriptional regulator","http://www.ncbi.nlm.nih.gov/gene/?term=10413","10413","22601","363014",null,null,"704382","P46937","P46938","Q2EJA0","A0A8I3MI73",null,"A0A1D5QLM0","GO:0030054; GO:0005737; GO:0005829; GO:0001674; GO:0016020; GO:0005654; GO:0005634; GO:0140552; GO:0005667","GO:0003682; GO:0140297; GO:0140678; GO:0070064; GO:0005515; GO:0008022; GO:0000978; GO:0000976; GO:0003713; GO:0003714","GO:0001824; GO:0060449; GO:0060070; GO:0061026; GO:0000902; GO:0008283; GO:0006974; GO:0071480; GO:0071300; GO:0060242; GO:0003143; GO:1903703; GO:0050673; GO:0097191; GO:0002067; GO:0003015; GO:0035329; GO:0070102; GO:0060576; GO:0060575; GO:0030216; GO:0048368; GO:0060487; GO:1902018; GO:1904036; GO:0030857; GO:2001237; GO:0045599; GO:0010629; GO:2000737; GO:0000122; GO:0030903; GO:0035265; GO:0048339; GO:0090263; GO:0060045; GO:0030307; GO:0008284; GO:0045893; GO:0050679; GO:0010628; GO:0033148; GO:0045747; GO:0046622; GO:0045669; GO:1900182; GO:1902459; GO:0045944; GO:0050847; GO:0065003; GO:0060828; GO:0042127; GO:0010468; GO:0010837; GO:0072307; GO:0050767; GO:0072091; GO:0032570; GO:0035019; GO:0001894; GO:0001829; GO:0001570; GO:0042060","PTHR17616:SF9","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=16262|UniProtKB=P46937"]
["YB1",null,"YBX1","49","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1513",".CCP., .CP., .OP., .OT., .TRASR.",null,"Y-BOX-BINDING PROTEIN 1","cellular response to interleukin-7; CRD-mediated mRNA stabilization; embryonic morphogenesis; epidermis development; in utero embryonic development; miRNA transport; mRNA processing; mRNA stabilization; negative regulation of cellular senescence; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; negative regulation of striated muscle cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of translation; positive regulation of cell division; positive regulation of cytoplasmic translation; positive regulation of transcription by RNA polymerase II; protein localization to cytoplasmic stress granule; regulation of DNA-templated transcription; regulation of gene expression; RNA splicing; RNA transport; tRNA transport","C5-methylcytidine-containing RNA binding; chromatin binding; DNA binding; double-stranded DNA binding; GTPase binding; miRNA binding; mRNA binding; nucleic acid binding; protein binding; RNA binding; sequence-specific double-stranded DNA binding; single-stranded DNA binding","CRD-mediated mRNA stability complex; cytoplasm; cytoplasmic stress granule; cytosol; endoplasmic reticulum; extracellular exosome; extracellular region; histone pre-mRNA 3'end processing complex; intracellular membrane-bounded organelle; messenger ribonucleoprotein complex; nucleoplasm; nucleus; plasma membrane; ribonucleoprotein complex; synapse; U12-type spliceosomal complex","Akt signaling","Y-box binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=4904","4904","22608",null,"607025",null,null,"P67809","P62960","D3ZEV0","A0A8I3NPS8","A0A287AJD3",null,"GO:0070937; GO:0005737; GO:0010494; GO:0005829; GO:0005783; GO:0070062; GO:0005576; GO:0071204; GO:0043231; GO:1990124; GO:0005654; GO:0005634; GO:0005886; GO:1990904; GO:0045202; GO:0005689","GO:0062153; GO:0003682; GO:0003677; GO:0003690; GO:0051020; GO:0035198; GO:0003729; GO:0003676; GO:0005515; GO:0003723; GO:1990837; GO:0003697","GO:0098761; GO:0070934; GO:0048598; GO:0008544; GO:0001701; GO:1990428; GO:0006397; GO:0048255; GO:2000773; GO:1900152; GO:0051154; GO:0000122; GO:0017148; GO:0051781; GO:2000767; GO:0045944; GO:1903608; GO:0006355; GO:0010468; GO:0008380; GO:0050658; GO:0051031","PTHR11544:SF68","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8014|UniProtKB=P67809"]
["YB1 - phospho","Ser102","YBX1","49","rb",null,7,4,"n/a","n/a",8,8,"# 1176",".CCP., .CP., .OP., .OT., .TRASR.",null,"Y-BOX-BINDING PROTEIN 1","cellular response to interleukin-7; CRD-mediated mRNA stabilization; embryonic morphogenesis; epidermis development; in utero embryonic development; miRNA transport; mRNA processing; mRNA stabilization; negative regulation of cellular senescence; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; negative regulation of striated muscle cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of translation; positive regulation of cell division; positive regulation of cytoplasmic translation; positive regulation of transcription by RNA polymerase II; protein localization to cytoplasmic stress granule; regulation of DNA-templated transcription; regulation of gene expression; RNA splicing; RNA transport; tRNA transport","C5-methylcytidine-containing RNA binding; chromatin binding; DNA binding; double-stranded DNA binding; GTPase binding; miRNA binding; mRNA binding; nucleic acid binding; protein binding; RNA binding; sequence-specific double-stranded DNA binding; single-stranded DNA binding","CRD-mediated mRNA stability complex; cytoplasm; cytoplasmic stress granule; cytosol; endoplasmic reticulum; extracellular exosome; extracellular region; histone pre-mRNA 3'end processing complex; intracellular membrane-bounded organelle; messenger ribonucleoprotein complex; nucleoplasm; nucleus; plasma membrane; ribonucleoprotein complex; synapse; U12-type spliceosomal complex","Akt signaling","Y-box binding protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=4904","4904","22608",null,"607025",null,null,"P67809","P62960","D3ZEV0","A0A8I3NPS8","A0A287AJD3",null,"GO:0070937; GO:0005737; GO:0010494; GO:0005829; GO:0005783; GO:0070062; GO:0005576; GO:0071204; GO:0043231; GO:1990124; GO:0005654; GO:0005634; GO:0005886; GO:1990904; GO:0045202; GO:0005689","GO:0062153; GO:0003682; GO:0003677; GO:0003690; GO:0051020; GO:0035198; GO:0003729; GO:0003676; GO:0005515; GO:0003723; GO:1990837; GO:0003697","GO:0098761; GO:0070934; GO:0048598; GO:0008544; GO:0001701; GO:1990428; GO:0006397; GO:0048255; GO:2000773; GO:1900152; GO:0051154; GO:0000122; GO:0017148; GO:0051781; GO:2000767; GO:0045944; GO:1903608; GO:0006355; GO:0010468; GO:0008380; GO:0050658; GO:0051031","PTHR11544:SF68","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=8014|UniProtKB=P67809"]
["Yes",null,"YES1","60","rb",null,1,4,1,1,5,8,"# 1261",".CADH., .CCKR., .CSP., .DI., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .LMIG., .MIG., .OP., .OPA., .OT., .PARK., .ST., .TCR., .TRASR.","CCKR signaling map; Cadherin signaling pathway; Parkinson disease","TYROSINE-PROTEIN KINASE YES","cell differentiation; cellular response to platelet-derived growth factor stimulus; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; innate immune response; leukocyte migration; negative regulation of inflammatory response to antigenic stimulus; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription by RNA polymerase II; protein modification process; protein phosphorylation; regulation of glucose transmembrane transport; regulation of vascular permeability; T cell costimulation; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; enzyme binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity; transmembrane transporter binding","actin filament; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; Golgi apparatus; membrane; microtubule organizing center; plasma membrane","Hippo signaling","YES proto-oncogene 1, Src family tyrosine kinase","http://www.ncbi.nlm.nih.gov/gene/?term=7525","7525","22612",null,"403917",null,"697099","P07947","Q04736","A0A0G2K2V7","A0A8I3MFD9",null,"F6ZR07","GO:0005884; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0031234; GO:0005925; GO:0005794; GO:0016020; GO:0005815; GO:0005886","GO:0005524; GO:0019899; GO:0016301; GO:0004715; GO:0000166; GO:0001784; GO:0005515; GO:0004672; GO:0004713; GO:0005102; GO:0016740; GO:0044325","GO:0030154; GO:0036120; GO:0071300; GO:0071560; GO:0048013; GO:0038096; GO:0045087; GO:0050900; GO:0002862; GO:0018108; GO:0016310; GO:0050731; GO:0045944; GO:0036211; GO:0006468; GO:0010827; GO:0043114; GO:0031295; GO:0007169","PTHR24418:SF90","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12841|UniProtKB=P07947","P06959; P00012; P00049"]
["zap 70",null,"ZAP70","70","rb",null,1,4,"n/a","n/a","n/a","n/a","# 1893",".CSP., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","T cell activation","TYROSINE-PROTEIN KINASE ZAP-70","adaptive immune response; alpha-beta T cell differentiation; B cell activation; beta selection; calcium-mediated signaling; cell differentiation; immune response; immune system process; innate immune response; intracellular signal transduction; negative thymic T cell selection; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of immune response; positive regulation of leukocyte activation; positive regulation of T cell differentiation; positive thymic T cell selection; protein autophosphorylation; protein phosphorylation; T cell activation; T cell aggregation; T cell differentiation; T cell migration; T cell receptor signaling pathway; thymic T cell selection; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity","cell-cell junction; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; immunological synapse; membrane; membrane raft; plasma membrane; T cell receptor complex",null,"zeta chain of T cell receptor associated protein kinase 70","http://www.ncbi.nlm.nih.gov/gene/?term=7535","7535","22637",null,null,null,"707555","P43403","P43404",null,"A0A8I3P8U2","A0A5G2R169","F7FAI7","GO:0005911; GO:0005737; GO:0005829; GO:0031234; GO:0001772; GO:0016020; GO:0045121; GO:0005886; GO:0042101","GO:0005524; GO:0016301; GO:0004715; GO:0000166; GO:0001784; GO:0005515; GO:0004672; GO:0004713; GO:0005102; GO:0016740","GO:0002250; GO:0046632; GO:0042113; GO:0043366; GO:0019722; GO:0030154; GO:0006955; GO:0002376; GO:0045087; GO:0035556; GO:0045060; GO:0018108; GO:0016310; GO:0046638; GO:0046641; GO:0050850; GO:0050778; GO:0002696; GO:0045582; GO:0045059; GO:0046777; GO:0006468; GO:0042110; GO:0070489; GO:0030217; GO:0072678; GO:0050852; GO:0045061; GO:0007169","PTHR24418:SF369","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12858|UniProtKB=P43403","P00053"]
["zap 70",null,"ZAP70","70","rb",null,1,2,"n/a","n/a","n/a","n/a","# 1916",".CSP., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","T cell activation","TYROSINE-PROTEIN KINASE ZAP-70","adaptive immune response; alpha-beta T cell differentiation; B cell activation; beta selection; calcium-mediated signaling; cell differentiation; immune response; immune system process; innate immune response; intracellular signal transduction; negative thymic T cell selection; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of immune response; positive regulation of leukocyte activation; positive regulation of T cell differentiation; positive thymic T cell selection; protein autophosphorylation; protein phosphorylation; T cell activation; T cell aggregation; T cell differentiation; T cell migration; T cell receptor signaling pathway; thymic T cell selection; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity","cell-cell junction; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; immunological synapse; membrane; membrane raft; plasma membrane; T cell receptor complex",null,"zeta chain of T cell receptor associated protein kinase 70","http://www.ncbi.nlm.nih.gov/gene/?term=7535","7535","22637",null,null,null,"707555","P43403","P43404",null,"A0A8I3P8U2","A0A5G2R169","F7FAI7","GO:0005911; GO:0005737; GO:0005829; GO:0031234; GO:0001772; GO:0016020; GO:0045121; GO:0005886; GO:0042101","GO:0005524; GO:0016301; GO:0004715; GO:0000166; GO:0001784; GO:0005515; GO:0004672; GO:0004713; GO:0005102; GO:0016740","GO:0002250; GO:0046632; GO:0042113; GO:0043366; GO:0019722; GO:0030154; GO:0006955; GO:0002376; GO:0045087; GO:0035556; GO:0045060; GO:0018108; GO:0016310; GO:0046638; GO:0046641; GO:0050850; GO:0050778; GO:0002696; GO:0045582; GO:0045059; GO:0046777; GO:0006468; GO:0042110; GO:0070489; GO:0030217; GO:0072678; GO:0050852; GO:0045061; GO:0007169","PTHR24418:SF369","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12858|UniProtKB=P43403","P00053"]
["zap 70 - phospho","Tyr319/Syk Tyr352","ZAP70","72, 70","rb",null,2,4,"n/a","n/a","n/a","n/a","# 1917",".CSP., .CUR., .D300., .DAKT., .DRAS., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","T cell activation","TYROSINE-PROTEIN KINASE ZAP-70","adaptive immune response; alpha-beta T cell differentiation; B cell activation; beta selection; calcium-mediated signaling; cell differentiation; immune response; immune system process; innate immune response; intracellular signal transduction; negative thymic T cell selection; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of immune response; positive regulation of leukocyte activation; positive regulation of T cell differentiation; positive thymic T cell selection; protein autophosphorylation; protein phosphorylation; T cell activation; T cell aggregation; T cell differentiation; T cell migration; T cell receptor signaling pathway; thymic T cell selection; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity","cell-cell junction; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; immunological synapse; membrane; membrane raft; plasma membrane; T cell receptor complex",null,"zeta chain of T cell receptor associated protein kinase 70","http://www.ncbi.nlm.nih.gov/gene/?term=7535","7535","22637",null,null,null,"707555","P43403","P43404",null,"A0A8I3P8U2","A0A5G2R169","F7FAI7","GO:0005911; GO:0005737; GO:0005829; GO:0031234; GO:0001772; GO:0016020; GO:0045121; GO:0005886; GO:0042101","GO:0005524; GO:0016301; GO:0004715; GO:0000166; GO:0001784; GO:0005515; GO:0004672; GO:0004713; GO:0005102; GO:0016740","GO:0002250; GO:0046632; GO:0042113; GO:0043366; GO:0019722; GO:0030154; GO:0006955; GO:0002376; GO:0045087; GO:0035556; GO:0045060; GO:0018108; GO:0016310; GO:0046638; GO:0046641; GO:0050850; GO:0050778; GO:0002696; GO:0045582; GO:0045059; GO:0046777; GO:0006468; GO:0042110; GO:0070489; GO:0030217; GO:0072678; GO:0050852; GO:0045061; GO:0007169","PTHR24418:SF369","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12858|UniProtKB=P43403","P00053"]
["zap 70 - phospho","Tyr319/Syk Tyr352","ZAP70","72, 70","rb",null,1.1000000000000001,4,"n/a","n/a","n/a","n/a","# 1918",".CSP., .CUR., .D300., .DAKT., .DRAS., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","T cell activation","TYROSINE-PROTEIN KINASE ZAP-70","adaptive immune response; alpha-beta T cell differentiation; B cell activation; beta selection; calcium-mediated signaling; cell differentiation; immune response; immune system process; innate immune response; intracellular signal transduction; negative thymic T cell selection; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of immune response; positive regulation of leukocyte activation; positive regulation of T cell differentiation; positive thymic T cell selection; protein autophosphorylation; protein phosphorylation; T cell activation; T cell aggregation; T cell differentiation; T cell migration; T cell receptor signaling pathway; thymic T cell selection; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity","cell-cell junction; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; immunological synapse; membrane; membrane raft; plasma membrane; T cell receptor complex",null,"zeta chain of T cell receptor associated protein kinase 70","http://www.ncbi.nlm.nih.gov/gene/?term=7535","7535","22637",null,null,null,"707555","P43403","P43404",null,"A0A8I3P8U2","A0A5G2R169","F7FAI7","GO:0005911; GO:0005737; GO:0005829; GO:0031234; GO:0001772; GO:0016020; GO:0045121; GO:0005886; GO:0042101","GO:0005524; GO:0016301; GO:0004715; GO:0000166; GO:0001784; GO:0005515; GO:0004672; GO:0004713; GO:0005102; GO:0016740","GO:0002250; GO:0046632; GO:0042113; GO:0043366; GO:0019722; GO:0030154; GO:0006955; GO:0002376; GO:0045087; GO:0035556; GO:0045060; GO:0018108; GO:0016310; GO:0046638; GO:0046641; GO:0050850; GO:0050778; GO:0002696; GO:0045582; GO:0045059; GO:0046777; GO:0006468; GO:0042110; GO:0070489; GO:0030217; GO:0072678; GO:0050852; GO:0045061; GO:0007169","PTHR24418:SF369","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12858|UniProtKB=P43403","P00053"]
["zap 70 - phospho","Tyr493/Syk Tyr526","ZAP70","70","rb",null,4,4,"n/a","n/a","n/a","n/a","# 1919",".CSP., .CUR., .D300., .DAKT., .DRAS., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","T cell activation","TYROSINE-PROTEIN KINASE ZAP-70","adaptive immune response; alpha-beta T cell differentiation; B cell activation; beta selection; calcium-mediated signaling; cell differentiation; immune response; immune system process; innate immune response; intracellular signal transduction; negative thymic T cell selection; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of immune response; positive regulation of leukocyte activation; positive regulation of T cell differentiation; positive thymic T cell selection; protein autophosphorylation; protein phosphorylation; T cell activation; T cell aggregation; T cell differentiation; T cell migration; T cell receptor signaling pathway; thymic T cell selection; transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity","cell-cell junction; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; immunological synapse; membrane; membrane raft; plasma membrane; T cell receptor complex",null,"zeta chain of T cell receptor associated protein kinase 70","http://www.ncbi.nlm.nih.gov/gene/?term=7535","7535","22637",null,null,null,"707555","P43403","P43404",null,"A0A8I3P8U2","A0A5G2R169","F7FAI7","GO:0005911; GO:0005737; GO:0005829; GO:0031234; GO:0001772; GO:0016020; GO:0045121; GO:0005886; GO:0042101","GO:0005524; GO:0016301; GO:0004715; GO:0000166; GO:0001784; GO:0005515; GO:0004672; GO:0004713; GO:0005102; GO:0016740","GO:0002250; GO:0046632; GO:0042113; GO:0043366; GO:0019722; GO:0030154; GO:0006955; GO:0002376; GO:0045087; GO:0035556; GO:0045060; GO:0018108; GO:0016310; GO:0046638; GO:0046641; GO:0050850; GO:0050778; GO:0002696; GO:0045582; GO:0045059; GO:0046777; GO:0006468; GO:0042110; GO:0070489; GO:0030217; GO:0072678; GO:0050852; GO:0045061; GO:0007169","PTHR24418:SF369","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=12858|UniProtKB=P43403","P00053"]
["ZFP64",null,"ZFP64","70","rb",null,2,6,1,6,2,2,"# 0915",".OP., .OT., .TRASR.",null,"ZINC FINGER PROTEIN 64","mesenchymal cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of gene expression","DNA binding; metal ion binding; protein binding","cytoplasm; megasporocyte nucleus; nucleus",null,"ZFP64 zinc finger protein","http://www.ncbi.nlm.nih.gov/gene/?term=55734","55734",null,null,"485932",null,null,"Q9NTW7","Q99KE8","A0A8I6A5Z8","A0A8I3Q2A1","A0A480HFR9","A0A5F8A829","GO:0005737; GO:0043076; GO:0005634","GO:0003677; GO:0046872; GO:0005515","GO:0048762; GO:0045944; GO:0010468","PTHR24403:SF43","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=15940|UniProtKB=Q9NTW7"]
["ZNRF3 (c-terminus)",null,"ZNRF3","101","rb",null,2,3,"n/a","n/a","n/a","n/a","# 1882",".CCP., .CP., .CSP., .DEV., .OP., .OT., .UBI., .WNT.",null,"E3 UBIQUITIN-PROTEIN LIGASE ZNRF3","limb development; negative regulation of canonical Wnt signaling pathway; negative regulation of non-canonical Wnt signaling pathway; negative regulation of Wnt signaling pathway; protein ubiquitination; regulation of canonical Wnt signaling pathway; regulation of Wnt signaling pathway, planar cell polarity pathway; stem cell proliferation; ubiquitin-dependent protein catabolic process; Wnt receptor catabolic process; Wnt signaling pathway","frizzled binding; metal ion binding; protein binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity","membrane; plasma membrane",null,"zinc and ring finger 3","http://www.ncbi.nlm.nih.gov/gene/?term=84133","84133","407821",null,null,null,null,"Q9ULT6","Q5SSZ7",null,"A0A8I3Q325","A0A287BIJ1","A0A5F8AAA0","GO:0016020; GO:0005886","GO:0005109; GO:0046872; GO:0005515; GO:0016740; GO:0061630; GO:0004842","GO:0060173; GO:0090090; GO:2000051; GO:0030178; GO:0016567; GO:0060828; GO:2000095; GO:0072089; GO:0006511; GO:0038018; GO:0016055","PTHR16200:SF3","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=18126|UniProtKB=Q9ULT6"]
["ZO-1",null,"TJP1","220","rb",null,2,4,8,7,7,8,"# 1857",".ANG., .APO., .CANCER., .CCP., .CD., .CP., .CSP., .MIG., .OP., .OT.",null,"TIGHT JUNCTION PROTEIN ZO-1","actomyosin structure organization; adherens junction maintenance; cell-cell adhesion; cell-cell junction assembly; cell-cell junction organization; establishment of endothelial intestinal barrier; maintenance of blood-brain barrier; negative regulation of actin cytoskeleton reorganization; negative regulation of apoptotic process; negative regulation of stress fiber assembly; positive regulation of blood-brain barrier permeability; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of sprouting angiogenesis; protein localization to adherens junction; protein localization to bicellular tight junction; protein localization to cell-cell junction; regulation of bicellular tight junction assembly; regulation of cell junction assembly; regulation of cytoskeleton organization","cadherin binding; calmodulin binding; cell adhesion molecule binding; protein binding","adherens junction; anchoring junction; apical junction complex; apical part of cell; basolateral plasma membrane; bicellular tight junction; cell junction; cell projection; cytoplasm; cytosol; gap junction; membrane; plasma membrane; podosome; protein-containing complex; tight junction","Adhesion","tight junction protein 1","http://www.ncbi.nlm.nih.gov/gene/?term=7082","7082","21872",null,null,null,null,"Q07157","P39447","A0A0G2K2P5","A0A8P0P585","A0A286ZRD4","A0A1D5QHY2","GO:0005912; GO:0070161; GO:0043296; GO:0045177; GO:0016323; GO:0005923; GO:0030054; GO:0042995; GO:0005737; GO:0005829; GO:0005921; GO:0016020; GO:0005886; GO:0002102; GO:0032991; GO:0070160","GO:0045296; GO:0005516; GO:0050839; GO:0005515","GO:0031032; GO:0034334; GO:0098609; GO:0007043; GO:0045216; GO:0090557; GO:0035633; GO:2000250; GO:0043066; GO:0051497; GO:1905605; GO:0030335; GO:0008284; GO:2000049; GO:1903672; GO:0071896; GO:1902396; GO:0150105; GO:2000810; GO:1901888; GO:0051493","PTHR13865:SF25","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=11827|UniProtKB=Q07157"]
["Zyxin",null,"ZYX","78","rb",null,2,8,"n/a","n/a","n/a","n/a","# 2859",".CSP., .DEV., .IIR., .IMFR., .IMUR., .INT., .OP., .OPA., .ST., .TGFB.",null,"ZYXIN","cell adhesion; cell-cell signaling; cell-matrix adhesion; cellular response to type II interferon; integrin-mediated signaling pathway; regulation of inflammatory response; signal transduction; stress fiber assembly; transforming growth factor beta receptor signaling pathway","metal ion binding; protein binding; RNA binding","actin cytoskeleton; adherens junction; anchoring junction; cytoplasm; cytoskeleton; cytosol; focal adhesion; nucleus; phagocytic vesicle; plasma membrane; stress fiber",null,"zyxin","http://www.ncbi.nlm.nih.gov/gene/?term=7791","7791","22793",null,null,null,"706407","Q15942","Q62523","A0A8I6AV84","A0A8I3NVB0","F1SRU2","H9ZDD0","GO:0015629; GO:0005912; GO:0070161; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0005634; GO:0045335; GO:0005886; GO:0001725","GO:0046872; GO:0005515; GO:0003723","GO:0007155; GO:0007267; GO:0007160; GO:0071346; GO:0007229; GO:0050727; GO:0007165; GO:0043149; GO:0007179","PTHR24212:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13200|UniProtKB=Q15942"]
["Zyxin - phospho","Ser142/Ser143","ZYX","78","rb",null,2,8,"n/a","n/a","n/a","n/a","# 2858",".CSP., .DEV., .IIR., .IMFR., .IMUR., .INT., .OP., .OPA., .ST., .TGFB.",null,"ZYXIN","cell adhesion; cell-cell signaling; cell-matrix adhesion; cellular response to type II interferon; integrin-mediated signaling pathway; regulation of inflammatory response; signal transduction; stress fiber assembly; transforming growth factor beta receptor signaling pathway","metal ion binding; protein binding; RNA binding","actin cytoskeleton; adherens junction; anchoring junction; cytoplasm; cytoskeleton; cytosol; focal adhesion; nucleus; phagocytic vesicle; plasma membrane; stress fiber",null,"zyxin","http://www.ncbi.nlm.nih.gov/gene/?term=7791","7791","22793",null,null,null,"706407","Q15942","Q62523","A0A8I6AV84","A0A8I3NVB0","F1SRU2","H9ZDD0","GO:0015629; GO:0005912; GO:0070161; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0005634; GO:0045335; GO:0005886; GO:0001725","GO:0046872; GO:0005515; GO:0003723","GO:0007155; GO:0007267; GO:0007160; GO:0071346; GO:0007229; GO:0050727; GO:0007165; GO:0043149; GO:0007179","PTHR24212:SF1","http://pantherdb.org/genes/gene.do?acc=HUMAN|HGNC=13200|UniProtKB=Q15942"]

{"sheet":"Code_Sheet","index":2,"n_rows":101,"n_cols":21,"rows_kept":101,"cut":false,"hidden":true,"merged":[]}
[null,".CSP.","Cellular Signaling pathways (CSP)",1101,null,"x","Functional Information",null,null,null,"score_digiwest_human",null,null,".CSP.",911,901,373,294,389,353,1101]
[null,".RTK.","Signalling Panels - (RTK)",683,null,"x","NMI_Ids",null,null,null,"score_digiwest_mouse",null,null,".RTK.",586,570,236,187,247,223,683]
[null,".FGFR.","FGFR = FGF signaling pathway",129,null,"x","NCBI Gene Information",null,null,null,"score_digiwest_rat",null,null,".FGFR.",113,116,53,44,61,56,129]
[null,".EGFR.","EGFR = EGF receptor signaling pathway",299,null,"x","Uniprot Ids",null,null,null,"score_digiwest_dog",null,null,".EGFR.",260,258,114,85,124,111,299]
[null,".ErbB.","ErbB = ErbB Signaling and Resistance",33,null,"x","GO Terms",null,null,null,"score_digiwest_minipig",null,null,".ErbB.",28,29,11,5,12,11,33]
[null,".MAPK.","MAPK = MAPK signaling pathway",420,null,"x","Panther Ids",null,null,null,"score_digiwest_cynomolgus",null,null,".MAPK.",359,344,140,113,154,138,420]
[null,".PDGF.","PDGF = PDGF signaling pathway",155,null,"x","all",null,null,"x","all",null,null,".PDGF.",133,139,60,39,62,58,155]
[null,".VEGFS.","VEGFS = VEGF signaling pathway",148,null,null,"none",null,null,null,null,null,null,".VEGFS.",130,129,59,41,61,56,148]
[null,".RAS.","RAS = Ras signaling pathway",288,null,null,null,null,null,null,null,null,null,".RAS.",253,250,99,78,103,93,288]
[null,".PI3K.","PI3K = PI3K-Akt signaling pathway",340,null,null,null,null,null,null,null,null,null,".PI3K.",297,287,113,91,124,115,340]
[null,".MTOR.","MTOR = mTOR signaling pathway",148,null,null,null,null,null,null,null,null,null,".MTOR.",135,134,52,39,57,52,148]
[null,".STAT.","STAT = JAK/STAT signaling pathway",118,null,null,null,null,null,null,null,null,null,".STAT.",104,100,44,36,50,44,118]
[null,".GPCR.","G-Protein (GPCR)",207,null,null,null,null,null,null,null,null,null,".GPCR.",178,175,77,59,75,72,207]
[null,".GPROT.","GPROT = G-protein coupled receptor signaling pathway",120,null,null,null,null,null,null,null,null,null,".GPROT.",102,99,44,31,42,37,120]
[null,".cAMP.","cAMP = cAMP signaling pathway",125,null,null,null,null,"human",1054,null,null,null,".cAMP.",110,109,45,37,47,48,125]
[null,".DEV.","Develometal Pathways (DEV)",419,null,null,null,null,"mouse",1036,null,null,null,".DEV.",353,351,157,124,154,145,419]
[null,".HIPPO.","HIPPO = hippo signaling",103,null,null,null,null,"rat",424,null,null,null,".HIPPO.",88,94,45,40,49,42,103]
[null,".HHSP.","HHSP = Hedgehog signaling pathway",50,null,null,null,null,"dog",326,null,null,null,".HHSP.",44,38,16,13,14,15,50]
[null,".NOTCH.","NOTCH = Notch signaling pathway",82,null,null,null,null,"minipig",436,null,null,null,".NOTCH.",67,68,35,25,33,28,82]
[null,".BMP.","BMP = BMP signaling pathway",45,null,null,null,null,"cynomolgus",391,null,null,null,".BMP.",40,37,18,15,19,18,45]
[null,".TGFB.","TGFB = TGF-beta signaling pathway",158,null,null,null,null,"all",1268,null,null,null,".TGFB.",131,133,58,44,54,49,158]
[null,".WNT.","WNT = Wnt signaling pathway",235,null,null,null,null,null,null,null,null,null,".WNT.",203,196,93,74,90,88,235]
[null,".SREME.","Stress and Metabolism (SREME)",532,null,null,null,null,null,null,null,null,null,".SREME.",452,452,184,142,196,178,532]
[null,".HIF.","HIF = Hyoxia and HIF-1 signaling pathway",227,null,null,null,null,null,null,null,null,null,".HIF.",194,196,84,65,91,82,227]
[null,".OXS.","OXS = Oxidative stress response",234,null,null,null,null,null,null,null,null,null,".OXS.",191,192,76,58,78,74,234]
[null,".JNK.","JNK = JNK cascade",73,null,null,null,null,null,null,null,null,null,".JNK.",57,65,25,28,28,24,73]
[null,".P38.","P38 = p38 MAPK pathway",63,null,null,null,null,null,null,null,null,null,".P38.",53,54,29,16,26,22,63]
[null,".AMPK.","AMPK = AMPK signaling pathway",108,null,null,null,null,null,null,null,null,null,".AMPK.",97,94,27,25,34,33,108]
[null,".INS.","INS = Insulin signaling pathway",257,null,null,null,null,null,null,null,null,null,".INS.",226,226,99,67,93,90,257]
[null,".IMUF.","Imunsignaling and Inflammation (IMUF)",455,null,null,null,null,null,null,null,null,null,".IMUF.",401,390,182,147,187,161,455]
[null,".BCR.","BCR = B cell receptor signaling pathway and activation",162,null,null,null,null,null,null,null,null,null,".BCR.",144,141,65,54,68,62,162]
[null,".TCR.","TCR = T cell receptor signaling pathway and activation",258,null,null,null,null,null,null,null,null,null,".TCR.",227,225,94,79,96,88,258]
[null,".INFG.","INFG = Interferon-gamma signaling pathway",65,null,null,null,null,null,null,null,null,null,".INFG.",55,58,31,26,25,21,65]
[null,".TOLL.","TOLL = Toll-like receptor signaling pathway",113,null,null,null,null,null,null,null,null,null,".TOLL.",102,99,43,37,48,40,113]
[null,".NFKB.","NFKB = NF-kappa B signaling pathway",170,null,null,null,null,null,null,null,null,null,".NFKB.",158,149,69,60,78,65,170]
[null,".INFM.","INFM = Inflammation mediated by chemokine and cytokine signaling pathway",243,null,null,null,null,null,null,null,null,null,".INFM.",218,204,99,81,103,89,243]
[null,".CD.","Cell Death Pathway Association (CD)",771,null,null,null,null,null,null,null,null,null,".CD.",649,648,279,226,287,255,771]
[null,".FAS.","FAS = FAS signaling pathway",50,null,null,null,null,null,null,null,null,null,".FAS.",42,46,22,17,24,23,50]
[null,".APO.","APO = Apoptosis signaling pathway",617,null,null,null,null,null,null,null,null,null,".APO.",524,518,216,175,225,200,617]
[null,".P53S.","P53S = p53 signaling pathway",218,null,null,null,null,null,null,null,null,null,".P53S.",187,190,75,65,87,78,218]
[null,".APH.","APH = Autophagic Processes",251,null,null,null,null,null,null,null,null,null,".APH.",217,211,90,70,94,86,251]
[null,".TNF.","TNF = TNF signaling pathway",180,null,null,null,null,null,null,null,null,null,".TNF.",157,163,65,50,67,55,180]
[null,".DDR.","DDR = cellular response to DNA damage stimulus",197,null,null,null,null,null,null,null,null,null,".DDR.",161,166,72,60,77,65,197]
[null,".DREP.","DREP = DNA repair",95,null,null,null,null,null,null,null,null,null,".DREP.",70,76,29,27,35,31,95]
[null,".OPA.","Other",908,null,null,null,null,null,null,null,null,null,".OPA.",766,750,312,240,320,292,908]
[null,".FOXO.","FOXO = FoxO signaling pathway",153,null,null,null,null,null,null,null,null,null,".FOXO.",137,139,55,51,58,55,153]
[null,".CADH.","CADH = Cadherin signaling pathway",54,null,null,null,null,null,null,null,null,null,".CADH.",52,48,27,19,29,27,54]
[null,".CCKR.","CCKR = CCKR signaling map",235,null,null,null,null,null,null,null,null,null,".CCKR.",215,213,113,79,102,94,235]
[null,".ENDO.","ENDO = Endothelin signaling pathway",74,null,null,null,null,null,null,null,null,null,".ENDO.",64,65,28,21,33,31,74]
[null,".INT.","INT = Integrin signalling pathway",216,null,null,null,null,null,null,null,null,null,".INT.",185,191,81,58,85,78,216]
[null,".ST.","ST = Signal Transduction",838,null,null,null,null,null,null,null,null,null,".ST.",704,687,287,222,292,264,838]
[null,".OP.","OTHER",1127,null,null,null,null,null,null,null,null,null,".OP.",938,924,377,289,391,349,1127]
[null,".CANCER.","Cancer Panels (CANCER)",540,null,null,null,null,null,null,null,null,null,".CANCER.",456,462,197,154,201,187,540]
[null,".CANPTHW.","CANPTHW = Pathways in cancer",385,null,null,null,null,null,null,null,null,null,".CANPTHW.",325,339,147,116,143,137,385]
[null,".CAMET.","CAMET = Central carbon metabolism in cancer",118,null,null,null,null,null,null,null,null,null,".CAMET.",106,99,40,33,48,43,118]
[null,".AML.","AML = Acute myeloid leukemia",107,null,null,null,null,null,null,null,null,null,".AML.",98,96,40,30,43,38,107]
[null,".BLC.","BLC = Bladder cancer",101,null,null,null,null,null,null,null,null,null,".BLC.",89,93,35,23,31,28,101]
[null,".BRC.","BRC = Breast cancer",182,null,null,null,null,null,null,null,null,null,".BRC.",155,163,60,53,64,62,182]
[null,".CML.","CML = Chronic myeloid leukemia",141,null,null,null,null,null,null,null,null,null,".CML.",124,126,50,44,54,44,141]
[null,".CRC.","CRC = Colorectal cancer",158,null,null,null,null,null,null,null,null,null,".CRC.",138,141,64,57,67,63,158]
[null,".EMC.","EMC = Endometrial cancer",141,null,null,null,null,null,null,null,null,null,".EMC.",128,127,58,50,65,62,141]
[null,".GLI.","GLI = Glioma",131,null,null,null,null,null,null,null,null,null,".GLI.",116,116,40,33,43,40,131]
[null,".MEL.","MEL = Melanoma",129,null,null,null,null,null,null,null,null,null,".MEL.",115,113,46,40,48,44,129]
[null,".NSCLC.","NSCLC = Non-small cell lung cancer",151,null,null,null,null,null,null,null,null,null,".NSCLC.",135,132,53,43,53,49,151]
[null,".PAC.","PAC = Pancreatic cancer",160,null,null,null,null,null,null,null,null,null,".PAC.",137,142,57,49,59,53,160]
[null,".PRC.","PRC = Prostate cancer",176,null,null,null,null,null,null,null,null,null,".PRC.",158,158,64,55,68,65,176]
[null,".RCC.","RCC = Renal cell carcinoma",95,null,null,null,null,null,null,null,null,null,".RCC.",85,80,41,34,40,38,95]
[null,".SCLC.","SCLC = Small cell lung cancer",120,null,null,null,null,null,null,null,null,null,".SCLC.",106,104,43,34,44,40,120]
[null,".TYR.","TYR = Thyroid cancer",66,null,null,null,null,null,null,null,null,null,".TYR.",59,61,27,22,23,21,66]
[null,".ANG.","ANG = Angiogenesis",287,null,null,null,null,null,null,null,null,null,".ANG.",238,239,101,81,110,103,287]
[null,".CCP.","Cell Cycle and Proliferation (CCP)",742,null,null,null,null,null,null,null,null,null,".CCP.",618,625,268,213,286,263,742]
[null,".CCY.","CCY = Cell cycle",402,null,null,null,null,null,null,null,null,null,".CCY.",338,346,160,119,163,146,402]
[null,".CP.","CP = cell growth and proliferation",632,null,null,null,null,null,null,null,null,null,".CP.",530,535,222,182,244,227,632]
[null,".DI.","Diseases",366,null,null,null,null,null,null,null,null,null,".DI.",315,321,154,124,152,137,366]
[null,".ALZ.","ALZ = Alzheimer disease",216,null,null,null,null,null,null,null,null,null,".ALZ.",185,188,86,70,89,86,216]
[null,".HEPB.","HEPB = Hepatitis B",219,null,null,null,null,null,null,null,null,null,".HEPB.",192,193,90,73,96,81,219]
[null,".HUNT.","HUNT = Huntington disease",107,null,null,null,null,null,null,null,null,null,".HUNT.",90,98,45,36,44,42,107]
[null,".PARK.","PARK = Parkinson disease",48,null,null,null,null,null,null,null,null,null,".PARK.",46,44,29,18,24,23,48]
[null,".IMUR.","Imunresponse (IMUR)",424,null,null,null,null,null,null,null,null,null,".IMUR.",360,350,146,105,137,120,424]
[null,".IIR.","IIR = innate immune response",133,null,null,null,null,null,null,null,null,null,".IIR.",110,102,40,28,36,28,133]
[null,".IMFR.","IMFR = inflammatory response",183,null,null,null,null,null,null,null,null,null,".IMFR.",161,151,65,44,63,50,183]
[null,".IMU.","IMUR = immune response",179,null,null,null,null,null,null,null,null,null,".IMU.",149,145,62,48,63,54,179]
[null,".LMIG.","LMIG = leukocyte migration",69,null,null,null,null,null,null,null,null,null,".LMIG.",57,61,31,20,26,22,69]
[null,".NEUT.","NEUT = neutrophil degranulation",0,null,null,null,null,null,null,null,null,null,".NEUT.",0,0,0,0,0,0,0]
[null,".VIR.","VIR = response to virus",167,null,null,null,null,null,null,null,null,null,".VIR.",145,140,58,44,58,49,167]
[null,".TMAT.","T-Cell Maturation (TMAT)",203,null,null,null,null,null,null,null,null,null,".TMAT.",168,180,73,61,72,68,203]
[null,".TCD.","TCD = Tcell differentiation",172,null,null,null,null,null,null,null,null,null,".TCD.",142,152,60,50,57,53,172]
[null,".TD.","TD = thymus development",49,null,null,null,null,null,null,null,null,null,".TD.",42,40,23,19,23,23,49]
[null,".OT.","Other",924,null,null,null,null,null,null,null,null,null,".OT.",769,759,315,237,319,288,924]
[null,".DRR.","DRR = response to drug",224,null,null,null,null,null,null,null,null,null,".DRR.",188,180,82,59,79,72,224]
[null,".MIG.","MIG = cell migration",332,null,null,null,null,null,null,null,null,null,".MIG.",279,266,117,90,129,115,332]
[null,".PLAT.","PLAT = Platelet",130,null,null,null,null,null,null,null,null,null,".PLAT.",114,113,51,38,58,50,130]
[null,".TRASR.","TRASR = Transcription and Gene Expression",761,null,null,null,null,null,null,null,null,null,".TRASR.",640,627,259,204,266,232,761]
[null,".UBI.","UBI = protein ubiquitination",101,null,null,null,null,null,null,null,null,null,".UBI.",80,85,40,37,44,40,101]
[null,".CUR.","Pathways Activity Panel",242,null,null,null,null,null,null,null,null,null,".CUR.",242,220,88,60,96,86,242]
[null,".D100.","D100 = core drugable pathway panel",90,null,null,null,null,null,null,null,null,null,".D100.",90,86,37,23,43,39,90]
[null,".D200.","D200 = extended drugable pathway panel",184,null,null,null,null,null,null,null,null,null,".D200.",184,170,71,45,76,68,184]
[null,".D300.","D300 = full drugable pathway panel",242,null,null,null,null,null,null,null,null,null,".D300.",242,220,88,60,96,86,242]
[null,".DMTOR.","DMTOR = drugable MTOR Panel",116,null,null,null,null,null,null,null,null,null,".DMTOR.",116,109,39,29,45,40,116]
[null,".DAKT.","DAKT = drugable PI3K-AKT Panel",165,null,null,null,null,null,null,null,null,null,".DAKT.",165,148,57,44,63,57,165]
[null,".DRAS.","DRAS = drugable RAS-RAF-ERK Panel",137,null,null,null,null,null,null,null,null,null,".DRAS.",137,125,48,29,51,46,137]

{"sheet":"Panel_Overview","index":3,"n_rows":102,"n_cols":8,"rows_kept":102,"cut":false,"hidden":false,"merged":[]}
["Number of antibodies per panel","human","mouse","rat","dog","minipig","cynomolgus","all_unfiltered"]
["Cellular Signaling Pathways Panels",911,901,373,294,389,353,1101]
["Signaling Panels",586,570,236,187,247,223,683]
["FGF signaling pathway",113,116,53,44,61,56,129]
["EGF receptor signaling pathway",260,258,114,85,124,111,299]
["ErbB signaling and resistance",28,29,11,5,12,11,33]
["MAPK signaling pathway",359,344,140,113,154,138,420]
["PDGF signaling pathway",133,139,60,39,62,58,155]
["VEGF signaling pathway",130,129,59,41,61,56,148]
["Ras signaling pathway",253,250,99,78,103,93,288]
["PI3K-Akt signaling pathway",297,287,113,91,124,115,340]
["mTOR signaling pathway",135,134,52,39,57,52,148]
["JAK/STAT signaling pathway",104,100,44,36,50,44,118]
["G-Protein",178,175,77,59,75,72,207]
["G-protein coupled receptor signaling pathway",102,99,44,31,42,37,120]
["cAMP signaling pathway",110,109,45,37,47,48,125]
["Developmental Pathways",353,351,157,124,154,145,419]
["Hippo signaling pathway",88,94,45,40,49,42,103]
["Hedgehog signaling pathway",44,38,16,13,14,15,50]
["Notch signaling pathway",67,68,35,25,33,28,82]
["BMP signaling pathway",40,37,18,15,19,18,45]
["TGF-beta signaling pathway",131,133,58,44,54,49,158]
["Wnt signaling pathway",203,196,93,74,90,88,235]
["Stress and Metabolism",452,452,184,142,196,178,532]
["Hypoxia and HIF-1 signaling pathway",194,196,84,65,91,82,227]
["Oxidative stress response",191,192,76,58,78,74,234]
["JNK cascade",57,65,25,28,28,24,73]
["p38 MAPK pathway",53,54,29,16,26,22,63]
["AMPK signaling pathway",97,94,27,25,34,33,108]
["Insulin signaling pathway",226,226,99,67,93,90,257]
["Immune Signaling and Inflammation",401,390,182,147,187,161,455]
["B cell receptor signaling pathway and activation",144,141,65,54,68,62,162]
["T cell receptor signaling pathway and activation",227,225,94,79,96,88,258]
["Interferon-gamma signaling pathway",55,58,31,26,25,21,65]
["Toll-like receptor signaling pathway",102,99,43,37,48,40,113]
["NF-kappa B signaling pathway",158,149,69,60,78,65,170]
["Inflammation mediated by chemokine and cytokine signaling pathway",218,204,99,81,103,89,243]
["Cell Death Pathway Association",649,648,279,226,287,255,771]
["FAS signaling pathway",42,46,22,17,24,23,50]
["Apoptosis signaling pathway",524,518,216,175,225,200,617]
["p53 signaling pathway",187,190,75,65,87,78,218]
["Autophagic processes",217,211,90,70,94,86,251]
["TNF signaling pathway",157,163,65,50,67,55,180]
["Cellular response to DNA damage stimulus",161,166,72,60,77,65,197]
["DNA repair",70,76,29,27,35,31,95]
["Other Pathways",766,750,312,240,320,292,908]
["FoxO signaling pathway",137,139,55,51,58,55,153]
["Cadherin signaling pathway",52,48,27,19,29,27,54]
["CCKR signaling map",215,213,113,79,102,94,235]
["Endothelin signaling pathway",64,65,28,21,33,31,74]
["Integrin signaling pathway",185,191,81,58,85,78,216]
["Signal transduction",704,687,287,222,292,264,838]
["Other Panels",938,924,377,289,391,349,1127]
["Cancer Panels",456,462,197,154,201,187,540]
["Pathways in cancer",325,339,147,116,143,137,385]
["Central carbon metabolism in cancer",106,99,40,33,48,43,118]
["Acute myeloid leukemia",98,96,40,30,43,38,107]
["Bladder cancer",89,93,35,23,31,28,101]
["Breast cancer",155,163,60,53,64,62,182]
["Chronic myeloid leukemia",124,126,50,44,54,44,141]
["Colorectal cancer",138,141,64,57,67,63,158]
["Endometrial cancer",128,127,58,50,65,62,141]
["Glioma",116,116,40,33,43,40,131]
["Melanoma",115,113,46,40,48,44,129]
["Non-small cell lung cancer",135,132,53,43,53,49,151]
["Pancreatic cancer",137,142,57,49,59,53,160]
["Prostate cancer",158,158,64,55,68,65,176]
["Renal cell carcinoma",85,80,41,34,40,38,95]
["Small cell lung cancer",106,104,43,34,44,40,120]
["Thyroid cancer",59,61,27,22,23,21,66]
["Angiogenesis",238,239,101,81,110,103,287]
["Cell Cycle and Proliferation",618,625,268,213,286,263,742]
["Cell Cycle",338,346,160,119,163,146,402]
["Cell growth and proliferation",530,535,222,182,244,227,632]
["Diseases",315,321,154,124,152,137,366]
["Alzheimer disease",185,188,86,70,89,86,216]
["Hepatitis B",192,193,90,73,96,81,219]
["Huntington disease",90,98,45,36,44,42,107]
["Parkinson disease",46,44,29,18,24,23,48]
["Immune Processes",360,350,146,105,137,120,424]
["Innate immune response",110,102,40,28,36,28,133]
["Inflammatory response",161,151,65,44,63,50,183]
["Immune response",149,145,62,48,63,54,179]
["Leukocyte migration",57,61,31,20,26,22,69]
["Neutrophil degranulation"]
["Response to virus",145,140,58,44,58,49,167]
["T Cell Maturation",168,180,73,61,72,68,203]
[" T cell differentiation",142,152,60,50,57,53,172]
["Thymus development",42,40,23,19,23,23,49]
["Other Processes",769,759,315,237,319,288,924]
["Response to drug",188,180,82,59,79,72,224]
["Cell migration",279,266,117,90,129,115,332]
["Platelet",114,113,51,38,58,50,130]
["Transcription and gene expression",640,627,259,204,266,232,761]
["Protein ubiquitination",80,85,40,37,44,40,101]
["Pathway Activity Panels",242,220,88,60,96,86,242]
["Core Druggable Pathway Panel",90,86,37,23,43,39,90]
["Extended Druggable Pathway Panel",184,170,71,45,76,68,184]
["Full Druggable Pathway Panel",242,220,88,60,96,86,242]
["mTOR Pathway",116,109,39,29,45,40,116]
["PI3K / AKT Pathway",165,148,57,44,63,57,165]
["RTK / MAPK Pathway",137,125,48,29,51,46,137]

{"sheet":"Pathway Activity Panels","index":4,"n_rows":244,"n_cols":11,"rows_kept":244,"cut":false,"hidden":false,"merged":[[0,0,0,4],[0,6,0,7]]}
[null,null,null,null,null,{"$f":"COUNTA(F3:F244)","v":0}]
["antigen_name","antigen_modification_site","ncbi_gene_name_human","molweight_human","antibody_supplier_source","Selection\n(X)","score_digiwest_human","score_digiwest_mouse","Pathway_Search_Tag","function","drug"]
["4E-BP1",null,"EIF4EBP1","13","rb",null,1,1,".AML., .AMPK., .CANCER., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .P53S., .PI3K., .RTK., .SREME., .TRASR.","4E-BP1 (eIF4EBP1)  inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation controlled through  PI3 kinase/Akt and FRAP/mTOR pathway disrupts this interaction resulting in activation of cap-dependent translation."]
["4E-BP1 - phospho","Ser65","EIF4EBP1","20-15","rb",null,2,2,".AML., .AMPK., .CANCER., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D200., .D300., .DMTOR., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .P53S., .PI3K., .RTK., .SREME., .TRASR.","Multiple 4E-BP1 residues are phosphorylated in vivo. Hyperphosphorylation controlled through PI3 kinase/Akt and FRAP/mTOR pathway disrupts the inhibitory interaction with eIF4E, resulting in activation of cap-dependent translation. Phosphorylation of Thr37/Thr46 is followed by Thr70 phosphorylation, and Ser65 is phosphorylated last. Phosphorylation of Ser65 and Thr70 alone is insufficient to block binding to eIF4E. Alternative seqeunce of events have been proposed using rats in which Thr70 (human equivalent) is phosphorylated first followed by Thr37/Thr45 phosphorylation, and Ser65 is phosphorylated last. Thr70 phosphorylation alone allows binding to eIF4E, and subsequent Thr37/Thr45 phosphorylation was sufficient to dissociate 4E-BP1 from eIF4E."]
["4E-BP1 - phospho","Thr37/Thr46","EIF4EBP1","20-15","rb",null,2,2,".AML., .AMPK., .CANCER., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .P53S., .PI3K., .RTK., .SREME., .TRASR.","Multiple 4E-BP1 residues are phosphorylated in vivo. Hyperphosphorylation controlled through PI3 kinase/Akt and FRAP/mTOR pathway disrupts the inhibitory interaction with eIF4E, resulting in activation of cap-dependent translation. Phosphorylation of Thr37/Thr46 is followed by Thr70 phosphorylation, and Ser65 is phosphorylated last. Phosphorylation of Ser65 and Thr70 alone is insufficient to block binding to eIF4E. Alternative seqeunce of events have been proposed using rats in which Thr70 (human equivalent) is phosphorylated first followed by Thr37/Thr45 phosphorylation, and Ser65 is phosphorylated last. Thr70 phosphorylation alone allows binding to eIF4E, and subsequent Thr37/Thr45 phosphorylation was sufficient to dissociate 4E-BP1 from eIF4E."]
["4E-BP1 - phospho","Thr70","EIF4EBP1","20-15","rb",null,2,2,".AML., .AMPK., .CANCER., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .P53S., .PI3K., .RTK., .SREME., .TRASR.","Multiple 4E-BP1 residues are phosphorylated in vivo. Hyperphosphorylation controlled through PI3 kinase/Akt and FRAP/mTOR pathway disrupts the inhibitory interaction with eIF4E, resulting in activation of cap-dependent translation. Phosphorylation of Thr37/Thr46 is followed by Thr70 phosphorylation, and Ser65 is phosphorylated last. Phosphorylation of Ser65 and Thr70 alone is insufficient to block binding to eIF4E. Alternative seqeunce of events have been proposed using rats in which Thr70 (human equivalent) is phosphorylated first followed by Thr37/Thr45 phosphorylation, and Ser65 is phosphorylated last. Thr70 phosphorylation alone allows binding to eIF4E, and subsequent Thr37/Thr45 phosphorylation was sufficient to dissociate 4E-BP1 from eIF4E."]
["Akt (pan)",null,"AKT1, AKT2, AKT3","60","rb",null,1,1,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","Akt (PKB or Rac) important in controlling survival and apoptosis. Activated by insulin and various growth and survival factors involving PI3 kinases. PTEN is major negative regulator. Akt Promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of  e.g. Bad , FoxOs, c-Raf, and caspase-9. Akt regulates glycogen synthesis phosphorylation and inactivation of GSK-3α/β (Ser21/Ser9). Also role in insulin stimulation of glucose transport . Involved in cell cycle regulation preventing GSK-3β-mediated phosphorylation and degradation of cyclin D1. Also  and by negatively regulates CDK Inhibitors p27, p21. Role in cell growth directly phosphorylating mTOR in mTORC1 complex and inactivates tuberin (TSC2), an inhibitor of mTOR in mTORC1. ","Midostaurin"]
["Akt (pan) - phospho","Ser473","AKT1, AKT2, AKT3","60","rb",null,1.1000000000000001,1.1000000000000001,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","Akt activated by phospholipid binding, activation loop phosphorylation at Thr308 by PDK1 and by craboxy terminal phosphorylation at Ser473 by PDK2 (a taraget of mTOR/mTORC2 complex)","Midostaurin"]
["Akt (pan) - phospho","Thr308","AKT1, AKT2, AKT3","60","rb",null,1,2,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","Akt activated by phospholipid binding, activation loop phosphorylation at Thr308 by PDK1 and by craboxy terminal phosphorylation at Ser473 by PDK2 (a taraget of mTOR/mTORC2 complex)","Midostaurin"]
["Akt (pan) - phospho","Thr450","AKT1, AKT2, AKT3","60","rb",null,2,2,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","Akt reactivated after ischemic injury through phosphorylating Thr450 by JNK,  priming event for subsequent phosphorylation by PDK1/2.","Midostaurin"]
["Akt1",null,"AKT1","60","rb",null,2,2,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","AKT1-specific substrates include palladin (PALLD) --> phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB) --> playing an important role in cell metabolism and proliferation; and CDKN1A (p21) -->  phosphorylation at Thr-145 induces its release from CDK2 and cytoplasmic relocalization.  AKT1 isoform more specific role in cell motility and proliferation. Phosphorylates CLK2 controlling cell survival to ionizing radiation.","Midostaurin"]
["Akt1 - phospho","Ser129","AKT1","60","rb",null,2,2,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","Phosphoryltion of Akt1 at Ser129 by CK1 promotes association of Akt1 with HSP90. Enhances Akt1 activity by inhibiting dephosphorylation of Akt1 at Thr308.  Can also enhance β-catenin transcriptional activity as well as cancer cell survival.","Midostaurin"]
["Akt1 - phospho","Ser473","AKT1","60","rb",null,1,4.0999999999999899,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MIG., .MTOR., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .UBI., .VEGFS.","Akt activated by phospholipid binding, activation loop phosphorylation at Thr308 by PDK1 and by craboxy terminal phosphorylation at Ser473 by PDK2 (a taraget of mTOR/mTORC2 complex)","Midostaurin"]
["Akt2",null,"AKT2","60","rb",null,1.1000000000000001,1.1000000000000001,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .HUNT., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","Specific substrates of AKT2 is PITX2 shortening the half-life of CCND1. Principal isoform for regulation of glucose uptake. Phosphorylates C2CD5 on Ser-197 during insulin-stimulated adipocytes. Specifically involved in skeletal muscle differentiation via its substrate ANKRD2. Influences expression of the phosphorylated form of BAD preventing caspase-dependent apoptosis. Phosphorylates CLK2 on Thr-343.","Midostaurin"]
["Akt2 - phospho","Ser474","AKT2","60","rb",null,2,1,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FAS., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .HUNT., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","Akt activated by phospholipid binding, activation loop phosphorylation at Thr308 by PDK1 and by craboxy terminal phosphorylation at Ser473 by PDK2 (Ser474 in Akt2) (a taraget of mTOR/mTORC2 complex)","Midostaurin"]
["Akt3",null,"AKT3","60","rb",null,1.1000000000000001,4,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .HUNT., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .VEGFS.","Mostly in Brain, Testes, Lung and Mammary tissue. Important in brain development and crucial for viability of malignant glioma cells. Potential key molecule in up- and down-regulation of MMP13 via IL13. Coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands.","Midostaurin"]
["AMPK alpha",null,"PRKAA1","62","rb",null,2,2,".AMPK., .APH., .APO., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DMTOR., .DRAS., .DRR., .FOXO., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .RTK., .SREME., .ST., .TRASR., .WNT.","AMPK has key role regulating energy homeostasis.Heterotrimeric complex of catalytic α and regulatory β and γ subunits; distinct genes (α1, 2; β1, 2; γ1, 2, 3). Activated by elevated AMP/ATP ratio due to stress, e.g.  heat shock, hypoxia, and ischemia. ccumulating Increasing evidence for modulating protein synthesis and cell growth through EF2 and TSC2/mTOR pathways, as well as blood flow via eNOS/nNOS."]
["AMPK alpha - phospho","Thr172","PRKAA1","62","rb",null,1,1,".AMPK., .APH., .APO., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DMTOR., .DRAS., .DRR., .FOXO., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .RTK., .SREME., .ST., .TRASR., .WNT.","LKB1, in association with STRAD and MO25, phosphorylates AMPKα at Thr172 in the activation loop; required for AMPK activation"]
["A-Raf",null,"ARAF","68","rb",null,2,2,".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CD., .CML., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .VEGFS.","A-Raf, B-Raf, and c-Raf are main effectors recruited by GTP-bound Ras activating MEK-MAP kinase pathway. Raf proteins are similar in sequence and function their regulation can be differential."]
["A-Raf - phospho","Tyr301/Tyr302","ARAF","68","rb",null,2,3,".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CD., .CML., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .VEGFS.","Activation of c-Raf involves phosphorylation at multiple activating sites including Ser338 phosphorylated by PAK. This region contains one highly conserved serine, which is present in all three RAF isoforms (Ser-299 in A-RAF, Ser-338 in C-RAF and Ser-446 in B-RAF) and two conserved tyrosines (Tyr-301/Tyr-302 in A-RAF and Tyr-340/Tyr-341 in C-RAF), which are substituted to aspartates in B-RAF. Phosphorylation of these sites positively regulates kinase activity of RAF kinases."]
["Bad",null,"BAD","23","rb",null,1.1000000000000001,4,".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DRR., .EGFR., .EMC., .GPCR., .HEPB., .HIF., .IMUF., .INFM., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .TCD., .TCR., .TMAT., .VEGFS.","Bad proapoptotic member of Bcl-2 family. Promotes cell death by displacing Bax from binding to Bcl-2 and Bcl-xL . Bad is inactivated  by survival factors, e.g. IL-3 activating signaling pathways leading to phosphorylation at Ser112 and Ser136. Phosphorylation promotes binding of Bad to 14-3-3 proteins thus  preventing association between Bad with Bcl-2 and Bcl-xL."]
["Bad - phospho","Ser112","BAD","23","rb",null,1,4,".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DRR., .EGFR., .EMC., .GPCR., .HEPB., .HIF., .IMUF., .INFM., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .TCD., .TCR., .TMAT., .VEGFS.","Bad is inactivated  by survival factors, e.g. IL-3 activating signaling pathways leading to phosphorylation at Ser112 and Ser136. Akt phosphorylates Bad at Ser136 promoting cell survival while phosphorylation at Ser112 is done by p90RSK and PKA (7). Phosphorylation at Ser155 by PKA critical  in blocking dimerization of Bad and Bcl-xL."]
["Bad - phospho","Ser136","BAD","23","rb",null,1.1000000000000001,4,".ALZ., .AML., .APH., .APO., .BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DRR., .EGFR., .EMC., .GPCR., .HEPB., .HIF., .IMUF., .INFM., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .TCD., .TCR., .TMAT., .VEGFS.","Bad is inactivated  by survival factors, e.g. IL-3 activating signaling pathways leading to phosphorylation at Ser112 and Ser136. Akt phosphorylates Bad at Ser136 promoting cell survival while phosphorylation at Ser112 is done by p90RSK and PKA (7). Phosphorylation at Ser155 by PKA critical  in blocking dimerization of Bad and Bcl-xL."]
["Bax",null,"BAX","20","rb",null,2,2,".APO., .BCR., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .EGFR., .EMC., .GLI., .HEPB., .HUNT., .IMUF., .IMUR., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .RTK., .SCLC., .ST., .TYR., .VIR.","Bax is key component for cellular induced apoptosis through mitochondrial stress. Upon activation, Bax forms oligomers and translocates to the mitochondrial membrane increasing  membrane's permeability. This leads to  cytochrome c release, caspase-9 activation and initiation of the caspase activation pathway for apoptosis."]
["Bcl-2",null,"BCL2","26","rb",null,1,8,".APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DRR., .EGFR., .HEPB., .HHSP., .HIF., .IMU., .IMUF., .IMUR., .MIG., .NFKB., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCD., .TCR., .TD., .TMAT., .TRASR., .UBI., .VIR.","Bcl-2has pro-survival function through inhibition of mitochondrial cytochrome c release and may modulate mitochondrial calcium homeostasis and proton flux.   Bcl-2 contains several phosphorylation Sites , including Thr56, Ser70, Thr74, and Ser87, that are target of the ASK1/MKK7/JNK1 pathway with, Ser70 phosphorylation potentially required for enhanced anti-apoptotic functions.","Venetoclax, Paclitaxel, Docetaxel, Eribulin"]
["Bcl-xL",null,"BCL2L1","30","rb",null,1,2,".APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DRR., .EGFR., .IMUF., .IMUR., .NFKB., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .RAS., .RTK., .SCLC., .ST., .STAT., .VIR.","Bcl-xL inhibits apoptosis through heterodimerization with an apoptotic protein inhibiting its apoptotic effect and stabilizing normal mitochondiral membrane states under stressful conditions. Bcl-xL is phosphorylated by JNK after treatment with microtubule-damaging agents."]
["beta-Catenin",null,"CTNNB1","92","rb",null,1,1,".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","β-Catenin is a key downstream effector in the Wnt signaling pathway implicated in inearly embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45 priming it for subsequent phosphorylation by GSK-3β.  GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 marking it for ubquintination and susequent degradation. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation and prevents nulcear localization. Upon Wnt signaling it accumulates in the nucleus where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Further it is involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion."]
["beta-Catenin - phospho","Ser33/Ser37/Thr41","CTNNB1","92","rb",null,1,5,".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Non-phosphorylated β-catenin is considered active."]
["beta-Catenin - phospho","Ser45","CTNNB1","92","rb",null,2.1,4,".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","CK1 phosphorylates β-catenin at Ser45 priming it for subsequent phosphorylation by GSK-3β.  GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 marking it for ubquintination and susequent degradation. "]
["beta-Catenin - phospho","Ser552","CTNNB1","92","rb",null,1,2,".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","Both Akt and PKA were shown to phosphorylate β-catenin at Ser552 inducing accumulation in the nucleus and increasing its transcriptional activity."]
["beta-Catenin - phospho","Ser675","CTNNB1","92","rb",null,1,1,".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","PKA was shown to phosphorylate β-catenin at Ser675 inducing  accumulation in the nucleus and increasing its transcriptional activity"]
["beta-Catenin (non-phospho Ser33/37/Thr41; active)",null,"CTNNB1","92","rb",null,2,1,".ALZ., .ANG., .APO., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .EMC., .FGFR., .HIPPO., .IMUF., .MAPK., .MIG., .NFKB., .OP., .OPA., .OT., .P53S., .PRC., .RTK., .ST., .TCR., .TD., .TMAT., .TRASR., .TYR., .UBI., .WNT.","GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Non-phosphorylated β-catenin is considered active."]
["B-Raf",null,"BRAF","95","rb",null,1.1000000000000001,8,".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .TYR., .VEGFS.","A-Raf, B-Raf, and c-Raf are main effectors recruited by GTP-bound Ras activating MEK-MAP kinase pathway. Raf proteins are similar in sequence and function their regulation can be differential. B-Raf contains three consensus Akt phosphorylation sites (Ser364, Ser428, and Thr439). Activating B-Raf mutation V600E is commonly found in malignant melanoma.","Vemurafenib, Azacitidine, Regorafenib, Dabrafenib"]
["B-Raf - phospho","Ser729","BRAF","84","rb",null,4,1.1000000000000001,".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .TYR., .VEGFS.","Phosphorylation of B-RAF Ser729 modulates cell-cycle progression and proliferation. BRAF is phosphorylated at Ser729 by AMPK promotin association of BRAF with 14-3-3 proteins and disrupts its interaction with the KSR1 scaffolding protein, leading to attenuation of the MEK-ERK signaling","Vemurafenib, Azacitidine, Regorafenib, Dabrafenib"]
["B-Raf - phospho","Ser445","BRAF","86","rb",null,2,1,".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .TYR., .VEGFS.","AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion. PAK (p21-activated protein kinase) phosphorylates c-Raf at Ser338 corresponding to Ser445 in B-Raf. Activation of c-Raf,  best understood, involves phosphorylation at multiple sites including Ser338, Tyr341, Thr491, Ser494, Ser497, and Ser499.","Vemurafenib, Azacitidine, Regorafenib, Dabrafenib"]
["B-Raf - phospho","Ser602","BRAF","84","rb",null,4,4,".ALZ., .AML., .ANG., .APO., .BCR., .BLC., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TMAT., .TRASR., .TYR., .VEGFS.","Ras promotes the in cis auto-phosphorylation of T599 and S602 in the evolutionary conserved TVKS-motif of the B-Raf activation loop ","Vemurafenib, Azacitidine, Regorafenib, Dabrafenib"]
["Caspase 9",null,"CASP9","47, 37, 35, 25 (hu); 51, 39, 37 (rt, mk)","ms",null,1,1,".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .EMC., .FAS., .HEPB., .HUNT., .NSCLC., .OP., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .VEGFS.","Caspase-9 is important in activation of apoptotic caspase cascades.  Apoptotic stimulation leads to cytochrome c release from mitochondria facilitating Apaf-1 mediated activation of caspase-9. This involves intrinsic proteolytic cleavage at Asp315,  producing a p35 subunit, and cleavage at Asp330, producing a p37 subunit which can amplify apoptotic response. Cleaved caspase-9 further processes other caspase members, such as caspase-3 and caspase-7, to initiating a caspase cascade leading to apoptosis. It also claves PARP."]
["Caspase 9 - phospho","Ser196","CASP9","46","rb",null,1,1,".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CD., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .EMC., .FAS., .HEPB., .HUNT., .NSCLC., .OP., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .VEGFS.","It has been shown that Akt targets caspase-9 at Ser196, downregulating its activity and decreasing apoptosis  "]
["cdc37 (p50Cdc37, HSP 90 chaperone protein kinase-targeting subunit)",null,"CDC37","45","rb",null,1,2,".APH., .CD., .CSP., .CUR., .D300., .DAKT., .IMUF., .INFG., .INFM., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","CDC37 is recruiting and stabilizing kinases within the HSP90 chaperone complex. CDC37 is important in multiple kinase pathways involved in proliferation and cancer cell survival (Raf, Akt, Src, ErbB2)"]
["CDK2",null,"CDK2","33","rb",null,1,2.1,".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DREP., .FOXO., .HEPB., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RAS., .RTK., .SCLC., .ST., .TRASR.","CDK2 is an important component of the cell cycle.Its kinase activity is regulated by phosphorylation as well as association with a cyclin subunit and a CDK inhibitor. Inhibition occurs through phosphorylation on Thr14 and Tyr15 and  association with p27 Kip1 and p21 Waf1/Cip1 . Activation requires dephosphorylation of Thr14 and Tyr15 by cdc25 phosphatase and phosphorylation of Thr160 by CAK (CDK7 - cyclin H Complex). CDK2/cyclin E kinase activity is important for the G1/S transition and phosphorylation of Rb. During S-phase, active CDK2/cyclin A complexes phosphorylate E2F. Active CDK2 complex persists in the nucleus throughout G2.","Bosutinib"]
["CDK2 - phospho","Thr160","CDK2","33","rb",null,2,2.1,".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DREP., .FOXO., .HEPB., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RAS., .RTK., .SCLC., .ST., .TRASR.","Activation requires dephosphorylation of Thr14 and Tyr15 by cdc25 phosphatase and phosphorylation of Thr160 by CAK (CDK7 - cyclin H Complex)","Bosutinib"]
["CDK4",null,"CDK4","30","rb",null,1,1,".BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DRAS., .DRR., .GLI., .IMUF., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .RTK., .SCLC., .SREME., .ST., .TCR., .TRASR.","CDK4 activity is regulated by T-loop phosphorylation at Thr172, by the abundance of its cyclin partners, and by binding with CDK inhibitors. The inactive complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27. This facilitaes , progression and pRb-dependent S-phase entry .The active cyclin D/CDK4 complex cause Rb-phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. ","Palbociclib, Ribociclib, Abemaciclib"]
["p15-INK4b (CDKN2B)",null,"CDKN2B","15","ms",null,4,4,".CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .FOXO., .OP., .OPA., .P53S., .SCLC., .ST., .TGFB.","p15INK4B interacts strongly with CDK4 and CDK6 and is a potent inhibitor. p15INK4B can potentially induce cell cycle arrest by acting as an effector of TGF-beta. "]
["c-Fos",null,"FOS","62","rb",null,1,4,".ANG., .APO., .BCR., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .GPCR., .HEPB., .HIF., .HUNT., .IMFR., .IMUF., .IMUR., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .PDGF., .RTK., .SREME., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR.","Belongs to FOS-Familiy of nuclear Oncogenes (c-Fos, FosB, FRA1,FRA2). Their expression is rapidly and transiently induced by a variety of extracellular stimuli. They dimerize with Jun proteins (c-Jun, JunB, and JunD) to form the Activator Protein-1 (AP-1) transcription factort that binds to TRE/AP-1 elements. Phosphorylation of Fos proteins by Erk may further increase transcriptional activity. Phosphorylation of c-Fos at Ser32 and Thr232 by Erk5 increases protein stability and nuclear localization"]
["c-Jun",null,"JUN","48, 43","rb",null,1,1,".ANG., .APH., .APO., .BCR., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .FAS., .GPCR., .HEPB., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VIR., .WNT.","c-Jun is a member of the Jun family(c-Jun, JunB, and Jun)  and a component of the transcription factor activator protein-1 (AP-1) composed of dimers with Fos. It activates transcription at TRE/AP-1 elements upon cxtracellular signals including growth factors, chemokines, and stress."]
["c-Jun - phospho","Ser63","JUN","48","rb",null,1.1000000000000001,4,".ANG., .APH., .APO., .BCR., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .FAS., .GPCR., .HEPB., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VIR., .WNT.","c-Jun is a member of the Jun family(c-Jun, JunB, and Jun)  and a component of the transcription factor activator protein-1 (AP-1) composed of dimers with Fos. It activates transcription at TRE/AP-1 elements upon cxtracellular signals including growth factors, chemokines, and stress. c-Jun transcriptional activity is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK. Radiation-Induced c-Jun Activation depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells. c-Jun has also been reported to become phosphorylated at the C-terminal sites Thr239 and Ser243 which may participate in its downregulation."]
["c-Jun - phospho","Ser73","JUN","48","rb",null,1,4,".ANG., .APH., .APO., .BCR., .BRC., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .FAS., .GPCR., .HEPB., .HUNT., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .VIR., .WNT.","c-Jun is a member of the Jun family(c-Jun, JunB, and Jun)  and a component of the transcription factor activator protein-1 (AP-1) composed of dimers with Fos. It activates transcription at TRE/AP-1 elements upon cxtracellular signals including growth factors, chemokines, and stress. c-Jun transcriptional activity is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK. Radiation-Induced c-Jun Activation depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells. c-Jun has also been reported to become phosphorylated at the C-terminal sites Thr239 and Ser243 which may participate in its downregulation."]
["c-Kit",null,"KIT","110","rb",null,1,7,".AML., .BCR., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .CUR., .D300., .DEV., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .STAT., .TCR., .TRASR.","Tyrosine-protein kinase  cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.  C-Kit phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1. Also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases ERK1/2. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules DAG and IP3. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation.","Cabozantinib, Pazopanib, Sunitinib, Axitinib, Azacitidine, Imatinib, Dasatinib, Nilotinib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib"]
["c-Met (HGF/SF receptor)",null,"MET","145","ms",null,2,6,".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D300., .DRAS., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.","Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates processes including proliferation, scattering, morphogenesis and survival.  Ligand binding induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1 leading to the activation of several signaling cascades including the RAS-ERK (morphogenic effects), PI3K-AKT (prosurvival), or PLCgamma-PKC.","Cabozantinib, Crizotinib, Brigatinib"]
["c-Met (HGF/SF receptor) - phospho","Tyr1349","MET","145","rb",null,2,4,".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D300., .DRAS., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.","Phosphorylation at Tyr1349 in the Met cytoplasmic domain provides a direct binding site for Gab1","Cabozantinib, Crizotinib, Brigatinib"]
["c-Myc",null,"MYC","70-57","rb",null,2,2,".AML., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DRAS., .DRR., .EGFR., .EMC., .HEPB., .HIF., .HIPPO., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .PDGF., .PI3K., .RTK., .SCLC., .SREME., .STAT., .TGFB., .TRASR., .TYR., .WNT.","Myc/Max/Mad network members act as transcriptional regulators in e.g proliferation, differentiation and apoptosis. Association with Max and either Myc or Mad can have opposing effects. Myc proteins are tightly regulated with short half-lives."]
["c-Myc - phospho","Ser62","MYC","62","rb",null,4,4,".AML., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DRAS., .DRR., .EGFR., .EMC., .HEPB., .HIF., .HIPPO., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .PDGF., .PI3K., .RTK., .SCLC., .SREME., .STAT., .TGFB., .TRASR., .TYR., .WNT.","Phosphorylation of c-Myc at Thr58 and Ser62 can control degradation. Phosphorylation  at these sites is a stepwise process, whereby phosphorylation at Ser62 occurs first , serving as a priming site for GSK-3 phosphorylation of Thr58."]
["c-Myc - phospho","Thr58","MYC","62","rb",null,2,2,".AML., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DRAS., .DRR., .EGFR., .EMC., .HEPB., .HIF., .HIPPO., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .PDGF., .PI3K., .RTK., .SCLC., .SREME., .STAT., .TGFB., .TRASR., .TYR., .WNT.","Phosphorylation of c-Myc at Thr58 and Ser62 can control degradation. Phosphorylation  at these sites is a stepwise process, whereby phosphorylation at Ser62 occurs first , serving as a priming site for GSK-3 phosphorylation of Thr58."]
["c-Myc - phospho","Thr58/Ser62","MYC","57","rb",null,2.1,4,".AML., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DRAS., .DRR., .EGFR., .EMC., .HEPB., .HIF., .HIPPO., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P53S., .PDGF., .PI3K., .RTK., .SCLC., .SREME., .STAT., .TGFB., .TRASR., .TYR., .WNT.","Phosphorylation of c-Myc at Thr58 and Ser62 can control degradation. Phosphorylation  at these sites is a stepwise process, whereby phosphorylation at Ser62 occurs first , serving as a priming site for GSK-3 phosphorylation of Thr58."]
["c-Raf",null,"RAF1","75-65","rb",null,2,1,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TD., .TMAT., .TRASR., .VEGFS.","A-Raf, B-Raf, and c-Raf are main effectors recruited by GTP-bound Ras activating MEK-MAP kinase pathway. Raf proteins are similar in sequence and function their regulation can be differential.","Vemurafenib, Azacitidine, Regorafenib, Dabrafenib"]
["c-Raf - phospho","Ser259","RAF1","74","rb",null,2,2,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TD., .TMAT., .TRASR., .VEGFS.","The inactive conformation of C-RAF is maintained by autoinhibitory interactions occurring between the N-terminal regulatory and the C-terminal catalytic domains and by the binding of a 14-3-3 protein that contacts two phosphorylation sites, Ser259 and Ser621. These can be phosphorylated by Akt and AMPK, respectively. C-Raf dephosphorylation in position 259 may preferentially occur in the course of C-Raf activation.","Vemurafenib, Azacitidine, Regorafenib, Dabrafenib"]
["c-Raf - phospho","Ser289/296/301","RAF1","74","rb",null,2,1,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TD., .TMAT., .TRASR., .VEGFS.","Hyperphosphorylation of c-Raf (Ser29, Ser43, Ser289, Ser296, Ser301, and Ser642) indicates inactivation. This hyperphosphorylation is dependent on downstream MEK signaling and renders c-Raf unresponsive to subsequent activation events.","Vemurafenib, Azacitidine, Regorafenib, Dabrafenib"]
["c-Raf - phospho","Ser338","RAF1","74","rb",null,2,4,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TCR., .TD., .TMAT., .TRASR., .VEGFS.","Activation of c-Raf involves phosphorylation at multiple activating sites including Ser338, Tyr341, Thr491, Ser494, Ser497, and Ser499 .PAK phosphorylates c-Raf at Ser338, and Src family phosphorylates Tyr341 to induce c-Raf activity. The phosphorylated form of c-RAF(on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'","Vemurafenib, Azacitidine, Regorafenib, Dabrafenib"]
["CREB",null,"CREB1","43","rb",null,2,1,".AMPK., .APO., .cAMP., .CANCER., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DRAS., .DRR., .GPCR., .GPROT., .HEPB., .HUNT., .INS., .OP., .OPA., .OT., .P38., .PI3K., .PRC., .RTK., .SREME., .ST., .TNF., .TRASR.","CREB is a bZIP transcription factor activating target genes through cAMP response elements. CREB is expressed in numerous tissues and plays a partuclarly large regulatory role in the nervous system. It  selectively activates numerous downstream genes through interactions with different dimerization partners."]
["CREB - phospho","Ser133","CREB1","43","rb",null,2,2,".AMPK., .APO., .cAMP., .CANCER., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DI., .DRAS., .DRR., .GPCR., .GPROT., .HEPB., .HUNT., .INS., .OP., .OPA., .OT., .P38., .PI3K., .PRC., .RTK., .SREME., .ST., .TNF., .TRASR.","CREB is activated by phosphorylation at Ser133 by various signaling pathways , e.g.  Erk, Ca2+, and stress signaling involving  p90RSK, MSK, CaMKIV, and MAPKAPK-2"]
["Cyclin D1",null,"CCND1","36","rb",null,1,4,".AML., .AMPK., .APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .DRR., .EMC., .FOXO., .GLI., .HHSP., .HIPPO., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR., .WNT.","Abundance of D-type cyclins regulate the activity of cyclin-dependent kinases CDK4 and CDK6. Mitogenic stimuli are reequired to remove p27 from the inactive ternary complex of cyclin D/CDK4 and p27 Kip1 which is subsequently degraded.This is  concomitant with a rise in cyclin D levels aiding progression through the restriction point and Rb-dependent  S-phase entry. The active cyclin D/CDK4 complex cause Rb-phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression.  Levels of cyclin D protein decrease in abscence of growth factors through reduced protein expression and phosphorylation-dependent degradation.","Ribociclib"]
["Cyclin D1 - phospho","Thr286","CCND1","33","rb",null,3,2,".AML., .AMPK., .APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .DRR., .EMC., .FOXO., .GLI., .HHSP., .HIPPO., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR., .WNT.","Cylcin D1 is phophorylated by GSK3ß at Thr286 promoting nuclear export and proteasomal degradation. GSK3ß is inhibited by AKT-mediated phosphorylation Ser9 thus increasing cyclin D1 abundance and promoting cell cylce progression.","Ribociclib"]
["DEPTOR/DEPDC6",null,"DEPTOR","48","rb",null,2,4,".APH., .APO., .CD., .CSP., .CUR., .D300., .DMTOR., .MTOR., .OPA., .RTK., .ST.","DEPTOR/DEPDC6 is a component of mTORC1 and mTORC2 complexes interacting with mTOR and inhibiting mTORC1 and mTORC2 kinase activities"]
["Dvl2",null,"DVL2","95-90","rb",null,2,1,".ALZ., .ANG., .BRC., .CANCER., .CANPTHW., .CCP., .CP., .CSP., .CUR., .D300., .DEV., .DI., .DMTOR., .HIPPO., .MAPK., .MTOR., .NOTCH., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.","Dishevelled proteins are important intermediates of Wnt signaling pathways inhibiting  GSK3β thus promoting β-catenin stabilization. They also bind to Fzd members, transducing the Wnt signal to down-stream effectors. They also participate in the planar cell polarity pathway by acting through JNK. Three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes and mediate endocytosis of the Fzd receptor after Wnt protein stimulation. Overexpression of Dvl has been reported in certain cancers."]
["Dvl3",null,"DVL3","93-88","rb",null,2,2,".ALZ., .ANG., .BRC., .CANCER., .CANPTHW., .CSP., .CUR., .D300., .DEV., .DI., .DMTOR., .HIPPO., .MAPK., .MTOR., .NOTCH., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.","Dishevelled proteins are important intermediates of Wnt signaling pathways inhibiting  GSK3β thus promoting β-catenin stabilization. They also bind to Fzd members, transducing the Wnt signal to down-stream effectors. They also participate in the planar cell polarity pathway by acting through JNK. Three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes and mediate endocytosis of the Fzd receptor after Wnt protein stimulation. Overexpression of Dvl has been reported in certain cancers."]
["EGF Receptor",null,"EGFR","175","rb",null,4,4,".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","EGF-Receptor is a transmembrane tyrosine kinase of the HER/ErbB protein family. Ligand binding results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation. Phosphorylated EGFR residues (Tyr1148 and Tyr1173) provide a docking site for the Shc scaffold protein, with both sites involved in MAP kinase signaling activation. PLCγ binds at phospho-Tyr992, resulting in activation of PLCγ-mediated downstream signaling.","Cabozantinib, Panitumumab, Afatinib, Lapatinib, Neratinib, Ramucirumab, Cetuximab, Trastuzumab, Gefitinib, Erlotinib, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib, Osimertinib, Necitumumab, Brigatinib"]
["EGF Receptor - phospho","Tyr1045","EGFR","175","rb",null,4,4,".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Phosphorylation of EGFR at Tyr1045 creates a major docking site for the adaptor protein c-Cbl, leading to receptor ubiquitination and degradation following EGFR activation","Cabozantinib, Panitumumab, Afatinib, Lapatinib, Neratinib, Ramucirumab, Cetuximab, Trastuzumab, Gefitinib, Erlotinib, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib, Osimertinib, Necitumumab, Brigatinib"]
["EGF Receptor - phospho","Tyr1068","EGFR","175","rb",null,4,4,".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","GRB2 adaptor protein binds activated EGFR at phospho-Tyr1068","Cabozantinib, Panitumumab, Afatinib, Lapatinib, Neratinib, Ramucirumab, Cetuximab, Trastuzumab, Gefitinib, Erlotinib, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib, Osimertinib, Necitumumab, Brigatinib"]
["EGF Receptor - phospho","Tyr845","EGFR","175","rb",null,4,4,".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","Tyr845 in the kinase domain is implicated in stabilizing the activation loop. c-Src is involved in phosphorylation of EGFR at Tyr845","Cabozantinib, Panitumumab, Afatinib, Lapatinib, Neratinib, Ramucirumab, Cetuximab, Trastuzumab, Gefitinib, Erlotinib, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib, Osimertinib, Necitumumab, Brigatinib"]
["EGF Receptor - phospho","Tyr992","EGFR","175","rb",null,4,4,".APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DRAS., .DREP., .EGFR., .EMC., .ErbB., .FOXO., .GLI., .HIF., .IMUF., .IMUR., .JNK., .MAPK., .MEL., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT., .TRASR., .VIR., .WNT.","PLCγ binds at phospho-Tyr992, resulting in activation of PLCγ-mediated downstream signaling.","Cabozantinib, Panitumumab, Afatinib, Lapatinib, Neratinib, Ramucirumab, Cetuximab, Trastuzumab, Gefitinib, Erlotinib, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib, Osimertinib, Necitumumab, Brigatinib"]
["eIF4B",null,"EIF4B","80","rb",null,4,4,".CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OP., .OT., .PI3K., .RTK., .TRASR.","Eukaryotic initiation factor 4B (eIF4B) assists the eIF4F complex in translation initiation. Heat shock and serum starvation cause dephosphorylation of eIF4B corresponding to inhibition of translation. Conversly, phosphorylation of eIF4B following insulin treatment correlates with increase in translation. "]
["eIF4B - phospho","Ser406","EIF4B","80","rb",null,1,4,".CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OP., .OT., .PI3K., .RTK., .TRASR.","Multiple kinases, such as p70 S6 kinase, can phosphorylate eIF4B . Ser406 was identified as a phosphorylation site regulated by mitogens dependent on MEK and mTOR activity  while being essential  for the translational activity"]
["eIF4B - phospho","Ser422","EIF4B","80","rb",null,1,1,".CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OP., .OT., .PI3K., .RTK., .TRASR.","Multiple kinases, such as p70 S6 kinase, can phosphorylate eIF4B . p70 S6 Kinase can phosphorylate eIF4B at the rapamycin-sensitive site Ser422 in vivo, promoting translation acvitiy."]
["eIF4E",null,"EIF4E","25","rb",null,1,1,".APH., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .PI3K., .RTK., .SREME., .TRASR.","eIF4E binds to the mRNA cap structure to mediate the initiation of translation. eIF4E interacts with the scaffold protein eIF4G promoting assembly of eIF4E and eIF4A into the eIF4F complex. eIF4E is phosphorylated by Mnk1 at Ser209 following mitogenic or stress stimuli via Erk or p38 MAPK."]
["eIF4E - phospho","Ser209","EIF4E","25","rb",null,1,1.1000000000000001,".APH., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .EGFR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .P38., .PI3K., .RTK., .SREME., .TRASR.","eIF4E binds to the mRNA cap structure to mediate the initiation of translation. eIF4E interacts with the scaffold protein eIF4G promoting assembly of eIF4E and eIF4A into the eIF4F complex. eIF4E is phosphorylated by Mnk1 at Ser209 following mitogenic or stress stimuli via Erk or p38 MAPK."]
["Elk-1",null,"ELK1","46","rb",null,2,2,".CANCER., .CANPTHW., .CCKR., .CSP., .CUR., .D100., .D200., .D300., .DI., .DRAS., .EGFR., .EMC., .HEPB., .IMUF., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .PARK., .PDGF., .RAS., .RTK., .SREME., .TOLL., .TRASR.","The Elk-1 transcription factor is a component of the ternary complex that binds the serum response element (SRE), mediating gene activity in response to serum and growth factors."]
["Elk-1 - phospho","Ser383","ELK1","47","ms",null,2,7,".CANCER., .CANPTHW., .CCKR., .CSP., .CUR., .D100., .D200., .D300., .DI., .DRAS., .EGFR., .EMC., .HEPB., .IMUF., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .PARK., .PDGF., .RAS., .RTK., .SREME., .TOLL., .TRASR.","Elk-1 is phosphorylated by MAP kinase pathways. Particularly  Ser383 phossphorylation is critical for transcriptional activation. Elk-1 (Ser383) is a target of MAP kinase and  the stress-activated kinase SAPK/JNK."]
["Erk1/2 (MAPK p44/42)",null,"MAPK3, MAPK1","44, 42","rb",null,1,1,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BMP., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","ERK1/2 are mitogen-activated protein kinases (MAPKs). The Erk1/2 signaling pathway can be activated in response extracellular stimuli such as mitogens, growth factors, and cytokines; Important target in the diagnosis and treatment of cancer. Stimulation, intiates a sequential three-part protein kinase cascade; MAPKKK or MAP3K >, MAPKK or MAP2K >MAPK.  MAP3Ks include members of the Raf family while the primary MAPKKs are MEK1/2 activate the MAPKs Erk1/2 through phosphorylation in the activation loop at Thr202/Tyr204 and Thr185/Tyr187 respectively. Downstream targets include p90RSK and transcription factor Elk-1. Negative regulation occurs  by dual-specificity (Thr/Tyr) MAPK phosphatases (DUSPs)"]
["Erk1/2 (MAPK p44/42) - phospho","Thr202/Tyr204","MAPK3, MAPK1","44, 42","rb",null,1,1,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BMP., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","MEK1/2 activate the MAPKs Erk1/2 through phosphorylation in the activation loop at Thr202/Tyr204 and Thr185/Tyr187 respectively. Downstream targets include p90RSK and transcription factor Elk-1. Negative regulation occurs by dual-specificity (Thr/Tyr) MAPK phosphatases (DUSPs)"]
["ERK1/2 (MAPK) - phospho","Thr202/Tyr204","MAPK3, MAPK1","44, 42","rb",null,1,1,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BMP., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .IMUR., .INFG., .INFM., .INS., .INT., .LMIG., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .PAC., .PARK., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCD., .TCR., .TD., .TGFB., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","MEK1/2 activate the MAPKs Erk1/2 through phosphorylation in the activation loop at Thr202/Tyr204 and Thr185/Tyr187 respectively. Downstream targets include p90RSK and transcription factor Elk-1. Negative regulation occurs by dual-specificity (Thr/Tyr) MAPK phosphatases (DUSPs)"]
["FAK1",null,"PTK2","125","rb",null,2,1,".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRAS., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","Focal adhesion kinase (FAK) is involved in integrin-mediated signal transduction playing a role in cell spreading, migration, and survival. FAK is activated by integrin clustering causing to autophosphorylation at Tyr397, a binding site for the Src family kinases PI3K and PLCγ. Recruitment of these kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region. "]
["FAK1 - phospho","Tyr397","PTK2","125","rb",null,1,4,".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRAS., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS."," FAK is activated by integrin clustering causing to autophosphorylation at Tyr397, a binding site for the Src family kinases PI3K and PLCγ. "]
["FAK1 - phospho","Tyr576/Tyr577","PTK2","125","rb",null,2.1,1,".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRAS., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","FAK is activated by integrin clustering causing to autophosphorylation at Tyr397, a binding site for the Src family kinases PI3K and PLCγ. Recruitment of these kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region. "]
["FAK1 - phospho","Tyr925","PTK2","125","rb",null,4,2.1,".ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRAS., .EGFR., .IIR., .IMUR., .INT., .LMIG., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .SCLC., .ST., .TGFB., .VEGFS.","FAK is activated by integrin clustering causing to autophosphorylation at Tyr397, a binding site for the Src family kinases PI3K and PLCγ. Recruitment of these kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region. "]
["FGF receptor (pan) - phospho","Tyr653/Tyr654","FGFR1, FGFR2, FGFR3, FGFR4","145, 120","ms",null,4,4,".ANG., .APO., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .DRR., .EGFR., .FGFR., .HHSP., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .ST., .STAT., .TRASR., .WNT."," FGFR1 can be phosphorylated at: Tyr463, 583, 585, 653, 654, 730, and 766 in its cytoplasmatic teail. Tyr653 and Tyr654 are essential for signaling . The other phosphorylation sites may provide docking sites for downstream signaling components such as Crk and PLCγ.","Pazopanib, Azacitidine, Regorafenib, Ponatinib, Lenvatinib"]
["FGF receptor 1",null,"FGFR1","145, 120, 92","rb",null,2,4,".ANG., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .FGFR., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .ST.","Tyrosine-protein kinase cell-surface receptor for FGF. Plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Activation of PLCG1 leads to the production of the cellular signaling molecules DAG and PI3P.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.","Pazopanib, Azacitidine, Regorafenib, Ponatinib, Lenvatinib"]
["FoxO1 - phospho","Ser319","FOXO1","120","rb",null,4,4,".AMPK., .APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .FOXO., .INS., .MAPK., .OP., .OPA., .OT., .OXS., .PI3K., .PRC., .RTK., .SREME., .TRASR., .WNT.","Forkhead family of transcription factors has three members (FoxO1, FoxO4, and FoxO3a).  Main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) while ist activity is supressed be Insulin.  Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Active forkhead members act as tumor suppressors by promoting cell cycle arrest and apoptosis. Increased expression of any FoxO member results in the activation of the cell cycle inhibitor p27 Kip1 and FoxOs also play a part in TGF-β-mediated upregulation of p21 Cip1, a process negatively regulated through PI3K . FoxOs are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319  resulting in nuclear export and inhibition of transcription factor activity allowing increased proliferation."]
["FoxO1",null,"FOXO1","82","rb",null,4,4,".AMPK., .APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .FOXO., .INS., .MAPK., .OP., .OPA., .OT., .OXS., .PI3K., .PRC., .RTK., .SREME., .TRASR., .WNT.","Forkhead family of transcription factors has three members (FoxO1, FoxO4, and FoxO3a).  Main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) while ist activity is supressed be Insulin.  Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Active forkhead members act as tumor suppressors by promoting cell cycle arrest and apoptosis. Increased expression of any FoxO member results in the activation of the cell cycle inhibitor p27 Kip1 and FoxOs also play a part in TGF-β-mediated upregulation of p21 Cip1, a process negatively regulated through PI3K . FoxOs are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319  resulting in nuclear export and inhibition of transcription factor activity. "]
["FoxO1 - phospho","Ser256","FOXO1","82","rb",null,2.1,7,".AMPK., .APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .FOXO., .INS., .MAPK., .OP., .OPA., .OT., .OXS., .PI3K., .PRC., .RTK., .SREME., .TRASR., .WNT.","Forkhead family of transcription factors has three members (FoxO1, FoxO4, and FoxO3a).  Main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) while ist activity is supressed be Insulin.  Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Active forkhead members act as tumor suppressors by promoting cell cycle arrest and apoptosis. Increased expression of any FoxO member results in the activation of the cell cycle inhibitor p27 Kip1 and FoxOs also play a part in TGF-β-mediated upregulation of p21 Cip1, a process negatively regulated through PI3K . FoxOs are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319  resulting in nuclear export and inhibition of transcription factor activity allowing increased proliferation."]
["FoxO1/O3a/O4 - phospho","Thr24/Thr32/Thr28","FOXO1, FOXO3, FOXO4","95, 82-78, 65","rb",null,2,2,".AMPK., .ANG., .APH., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MAPK., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .PRC., .RAS., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR., .WNT.","Forkhead family of transcription factors has three members (FoxO1, FoxO4, and FoxO3a). Active forkhead members act as tumor suppressors by promoting cell cycle arrest and apoptosis. Increased expression of any FoxO member results in the activation of the cell cycle inhibitor p27 Kip1 and FoxOs also play a part in TGF-β-mediated upregulation of p21 Cip1, a process negatively regulated through PI3K . FoxOs are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319  resulting in nuclear export and inhibition of transcription factor activity allowing increased proliferation."]
["FoxO3a",null,"FOXO3","97-82","rb",null,1,1,".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","Forkhead family of transcription factors has three members (FoxO1, FoxO4, and FoxO3a). Active forkhead members act as tumor suppressors by promoting cell cycle arrest and apoptosis. Increased expression of any FoxO member results in the activation of the cell cycle inhibitor p27 Kip1 and FoxOs also play a part in TGF-β-mediated upregulation of p21 Cip1, a process negatively regulated through PI3K . FoxOs are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319  resulting in nuclear export and inhibition of transcription factor activity allowing increased proliferation. Fox03a associates with 14-3-3 proteins upon phosphorylation by Akt and is retained in the cytoplasm. In the absence of survival factors, Fox03a is dephosphorylated, translocates to the nucleus and triggers cell death by a Fas ligand-dependent mechanism"]
["FoxO3a - phospho","Ser253","FOXO3","97","rb",null,4,6,".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","Forkhead family of transcription factors has three members (FoxO1, FoxO4, and FoxO3a). Active forkhead members act as tumor suppressors by promoting cell cycle arrest and apoptosis. Increased expression of any FoxO member results in the activation of the cell cycle inhibitor p27 Kip1 and FoxOs also play a part in TGF-β-mediated upregulation of p21 Cip1, a process negatively regulated through PI3K . FoxO3a is inactivated through phosphorylation by Ak (e.g. Ser253) resulting in association with 14-3-3 proteins, retention in the cytoplasm,  nuclear export and inhibition of transcription factor actiboty. In the absence of survival factors, Fox03a is dephosphorylated, translocates to the nucleus and triggers cell death by a Fas ligand-dependent mechanism. Phosphorylation  of  FOXO3a  by ERK1/2  at  Ser294,  Ser344  and Ser425  increases  FOXO3a-MDM2  interaction  and  enhances  FOXO3a  degradation  via an   MDM2-dependent  ubiquitin-proteasome pathway."]
["FoxO3a - phospho","Ser294","FOXO3","97-82","rb",null,2,4,".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","Phosphorylation  of  FOXO3a  by ERK1/2  at  Ser294,  Ser344  and Ser425  increases  FOXO3a-MDM2  interaction  and  enhances  FOXO3a  degradation  via an   MDM2-dependent  ubiquitin-proteasome pathway."]
["FoxO3a - phospho","Ser318/321","FOXO3","97","rb",null,4,4,".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","Phosphorylation at Ser318 and Ser321 by Akt is important for nuclear export of FoxO3a."]
["FoxO3a - phospho","Ser425","FOXO3","97-82","rb",null,4,4,".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","Phosphorylation  of  FOXO3a  by ERK1/2  at  Ser294,  Ser344  and Ser425  increases  FOXO3a-MDM2  interaction  and  enhances  FOXO3a  degradation  via an   MDM2-dependent  ubiquitin-proteasome pathway."]
["FoxO3a - phospho","Ser7","FOXO3","97-82","rb",null,4,4,".AMPK., .APH., .APO., .CANCER., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DRAS., .EGFR., .EMC., .FOXO., .IMUF., .INFM., .INS., .INT., .MIG., .NSCLC., .OP., .OPA., .OT., .OXS., .PI3K., .RTK., .SREME., .TCD., .TCR., .TMAT., .TNF., .TRASR.","p38 phosphorlyates FoxO3a at Ser7 and promotes its nuclear localization."]
["FRA1",null,"FOSL1","40-38","rb",null,2,4,".APO., .cAMP., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DRAS., .DRR., .GPCR., .IMUR., .OP., .OT., .OXS., .SREME., .TGFB., .TRASR., .VIR., .WNT.","FRA1 (FOSL1) belongs to the Fos family of nuclear oncogenes(c-Fos, FosB, FRA1,FRA2) which are nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators.  c-Fos proteins are only active as heterodimers with members of the Jun gene family forming Activator Protein-1 (AP-1)hat binds to TRE/AP-1 elements and activates transcription. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites. Activity is controled by exprssion and phosphorylation. Phosphorylation Erk kinases imay further increase transcriptional activity e.g. by increasing protein stability and nuclear localization. Phosphorylation occurs at Ser32 and Thr232 by Erk5 and at Ser252 and Ser265 by Erk1/2 leading to overexpression of FRA1 in cancer cells."]
["FRA1 - phospho","Ser265","FOSL1","40","rb",null,4,4,".APO., .cAMP., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DRAS., .DRR., .GPCR., .IMUR., .OP., .OT., .OXS., .SREME., .TGFB., .TRASR., .VIR., .WNT.","Phosphorylation of FRA1 at Ser252 and Ser265 by Erk1/2 increases protein stability and leads to overexpression of FRA1 in cancer cells. "]
["GRB10",null,"GRB10","76","rb",null,2,4,".CSP., .CUR., .D100., .D200., .D300., .DEV., .DMTOR., .INS., .MAPK., .MTOR., .OPA., .RTK., .SREME., .ST., .VEGFS., .WNT.","GRB10 is an adaptor protein that interacts with many RTKs as well as downstream signal molecules including Raf, Akt, and Nedd4. It binds to and suppress signals from activated RTKs by  interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling.  It is phosphorylated by mTORC1 at Ser150, Ser428, and Ser476 upon insulin stimulation"]
["GRB10 - phospho","Ser476","GRB10","80","rb",null,2,2,".CSP., .CUR., .D100., .D200., .D300., .DEV., .DMTOR., .INS., .MAPK., .MTOR., .OPA., .RTK., .SREME., .ST., .VEGFS., .WNT.","Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling.  It is phosphorylated by mTORC1 at Ser150, Ser428, and Ser476 upon insulin stimulation"]
["GSK-3 alpha",null,"GSK3A","51","rb",null,1,1,".APH., .APO., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DMTOR., .GPCR., .GPROT., .IMUR., .INS., .MIG., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR., .UBI., .VIR., .WNT.","GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase (GYS1 or GYS2) acts as a negative regulator in Wnt signaling. It is a critical downstream element of the PI3K/Akt  pathway. In response to insulin, it is inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. It is activated by phosphorylation at Tyr-279 and regulates cyclin D1 proteolysis and subcellular localization. It phosphorylates the anti-apoptotic protein MCL1 and may control apoptosis in response to growth factors deprivation."]
["GSK3 alpha/beta - phospho","Ser21/Ser9","GSK3A, GSK3B","51, 46","rb",null,1,1,".ALZ., .ANG., .APH., .APO., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .DMTOR., .EGFR., .EMC., .GPCR., .GPROT., .HHSP., .HIPPO., .IMUF., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .UBI., .VIR., .WNT.","GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase (GYS1 or GYS2) acts as a negative regulator in Wnt signaling. It is a critical downstream element of the PI3K/Akt  pathway. In response to insulin, it is inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. It is activated by phosphorylation at Tyr-279 and regulates cyclin D1 proteolysis and subcellular localization. It phosphorylates the anti-apoptotic protein MCL1 and may control apoptosis in response to growth factors deprivation."]
["GSK3 alpha/beta - phospho","Tyr279/Tyr216","GSK3A, GSK3B","51, 47","rb",null,1,1,".ALZ., .ANG., .APH., .APO., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .EGFR., .EMC., .GPCR., .GPROT., .HHSP., .HIPPO., .IMUF., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .UBI., .VIR., .WNT.","GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase (GYS1 or GYS2) acts as a negative regulator in Wnt signaling. It is a critical downstream element of the PI3K/Akt  pathway. In response to insulin, it is inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. It is activated by phosphorylation at Tyr-279 and regulates cyclin D1 proteolysis and subcellular localization. It phosphorylates the anti-apoptotic protein MCL1 and may control apoptosis in response to growth factors deprivation."]
["GSK3 beta",null,"GSK3B","46","rb",null,1,1,".ALZ., .ANG., .APH., .APO., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .EGFR., .EMC., .GPCR., .GPROT., .HHSP., .HIPPO., .IMUF., .IMUR., .INS., .INT., .MTOR., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .VIR., .WNT.","GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase (GYS1 or GYS2) acts as a negative regulator in Wnt signaling. It is a critical downstream element of the PI3K/Akt  pathway. In response to insulin, it is inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. It is activated by phosphorylation at Tyr-279 and regulates cyclin D1 proteolysis and subcellular localization. It phosphorylates the anti-apoptotic protein MCL1 and may control apoptosis in response to growth factors deprivation."]
["GSK3 beta - phospho","Ser9","GSK3B","46","rb",null,1,1,".ALZ., .ANG., .APH., .APO., .BCR., .BRC., .CADH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .EGFR., .EMC., .GPCR., .GPROT., .HHSP., .HIPPO., .IMUF., .IMUR., .INS., .INT., .MTOR., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .VIR., .WNT.","GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase (GYS1 or GYS2) acts as a negative regulator in Wnt signaling. It is a critical downstream element of the PI3K/Akt  pathway. In response to insulin, it is inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. It is activated by phosphorylation at Tyr-279 and regulates cyclin D1 proteolysis and subcellular localization. It phosphorylates the anti-apoptotic protein MCL1 and may control apoptosis in response to growth factors deprivation."]
["Her2 (ErbB2)",null,"ERBB2","185","rb",null,2,4,".ANG., .APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .EMC., .ErbB., .HIF., .IMUF., .MAPK., .NSCLC., .OP., .OPA., .OT., .PAC., .PI3K., .PRC., .RTK., .SREME., .ST., .TCR., .TRASR.","Transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product occur in almost 40% of breast cancers.  Important autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222; phosphorylation of these sites couples to Ras-Raf-MAP kinase signalling.","Afatinib, Lapatinib, Neratinib, Trastuzumab, Pertuzumab, Brigatinib"]
["Her2 (ErbB2) - phospho","Tyr1221/Tyr1222","ERBB2","185","rb",null,4,4,".ANG., .APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .EMC., .ErbB., .HIF., .IMUF., .MAPK., .NSCLC., .OP., .OPA., .OT., .PAC., .PI3K., .PRC., .RTK., .SREME., .ST., .TCR., .TRASR.","Transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product occur in almost 40% of breast cancers.  Important autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222; phosphorylation of these sites couples to Ras-Raf-MAP kinase signalling.","Afatinib, Lapatinib, Neratinib, Trastuzumab, Pertuzumab, Brigatinib"]
["Her2 (ErbB2) - phospho","Tyr1248","ERBB2","185","rb",null,2.1,2,".ANG., .APO., .BLC., .BRC., .CADH., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .EMC., .ErbB., .HIF., .IMUF., .MAPK., .NSCLC., .OP., .OPA., .OT., .PAC., .PI3K., .PRC., .RTK., .SREME., .ST., .TCR., .TRASR.","Transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product occur in almost 40% of breast cancers.  Important autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222; phosphorylation of these sites couples to Ras-Raf-MAP kinase signalling.","Afatinib, Lapatinib, Neratinib, Trastuzumab, Pertuzumab, Brigatinib"]
["Her3 (ErbB3)",null,"ERBB3","150","ms",null,4,4,".APO., .CADH., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .ErbB., .MAPK., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Member of the ErbB receptor protein tyrosine kinase family, but it lacks tyrosine kinase activity; depends on forming heterodimers with other ErbB tyrosine kinases to be phosphorylated. There are at least 9 potential tyrosine phosphorylation sites in the carboxy-termina region which are binding sites for signal transducing proteins, such as  Src family members, Grb2, and the p85 subunit of PI3 kinase. Both Tyr1222 and Tyr1289 participate in signaling to PI3K.  ErbB3 is highly expressed in many cancer cells and activation of the ErbB3/PI3K pathway is correlated with malignant phenotypes of adenocarcinomas."]
["Her3 (ErbB3) - phospho","Tyr1289","ERBB3","185","rb",null,4,4,".APO., .CADH., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .ErbB., .MAPK., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Member of the ErbB receptor protein tyrosine kinase family, but it lacks tyrosine kinase activity; depends on forming heterodimers with other ErbB tyrosine kinases to be phosphorylated. There are at least 9 potential tyrosine phosphorylation sites in the carboxy-termina region which are binding sites for signal transducing proteins, such as  Src family members, Grb2, and the p85 subunit of PI3 kinase. Both Tyr1222 and Tyr1289 participate in signaling to PI3K.  ErbB3 is highly expressed in many cancer cells and activation of the ErbB3/PI3K pathway is correlated with malignant phenotypes of adenocarcinomas."]
["Her4 (ErbB4)",null,"ERBB4","146","rb",null,2,7,".ALZ., .APO., .CADH., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DI., .DRAS., .EGFR., .ErbB., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .STAT., .TRASR.","Binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members resulting  in activation and signaling. ErbB4 expression is involved in both normal tissue development and carcinogenesis.  Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members. Mediates phosphorylation of SHC1 and activation of ERK1/2, phosphorylation of PIK3R1 (leading to the activation of Pi3K and AKT1 and protect cells against apoptosis), organization of the actin cytoskeleton and promots cell migration in response to NRG1.","Afatinib, Brigatinib"]
["Histone H3",null,"H3C1","17","rb",null,1,1,".CCP., .CCY., .CUR., .D200., .D300., .DRAS., .OP., .OT., .TRASR.","Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis. MSK1 phosphorylates Ser10 of histone H3 which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate Ser28 of histone H3."]
["Histone H3 - phospho","Ser10","H3C1","17","rb",null,1,4,".CCP., .CCY., .CUR., .D200., .D300., .DRAS., .OP., .OT., .TRASR.","Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis. MSK1 phosphorylates Ser10 of histone H3 which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate Ser28 of histone H3."]
["IGF-1R beta",null,"IGF1R","95","rb",null,2,4,".AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DMTOR., .DRR., .EGFR., .FOXO., .GLI., .HIF., .IMU., .IMUR., .INS., .JNK., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST.","IGF-IR is a transmembrane receptor tyrosine kinase widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Insulin receptors share significant structural and functional similarity with IGF-I receptors. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites and are necessary for kinase activation. Activated IGF1R is involved in cell growth and survival control and  is crucial for tumor transformation and survival of malignant cell. Activation leads to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins (IRS1/, Shc and 14-3-3 proteins). Phosphorylation of IRSs proteins lead to the activation of the PI3K-AKT/PKB pathway and the Ras-MAPK pathway.  Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of AKT/PKB which in in turn, enhances protein synthesis through mTOR activation and aoptosis inhibition by phosphorylation and inactivation of BAD. IGF1R signals also through the JAK/STAT pathway, phosphorylation of JAK leading to phosphorylation/activation of STAT proteins which activate gene transcription potentially responsible for the transforming activity (esp.STAT3). ","Brigatinib"]
["IGF-1R beta / IR beta - phospho","Tyr1135/Tyr1136resp.Tyr1150/Tyr1151","IGF1R, INSR","95","rb",null,4,4,".ALZ., .AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D300., .DI., .DMTOR., .DRR., .EGFR., .FOXO., .GLI., .GPCR., .GPROT., .HIF., .IMU., .IMUR., .INS., .JNK., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .TRASR., .VIR.","Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites and are necessary for kinase activation.  Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop.  ","Brigatinib"]
["IKK alpha",null,"CHUK","85","rb",null,2,2,".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR."," Activation depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα) leading to phosphorylation-induced, proteasome-mediated degradation of IκB relasing NF-κB/Rel transcription factors from inhibition."]
["IKK alpha - phospho","Thr23","CHUK","85","rb",null,4,4,".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","IKKa is indicated to be phosphrylated by AKT at Thr23 in turn activating mTORC1"]
["IKK alpha/beta - phospho","Ser176/177","CHUK, IKBKB","87, 85","rb",null,4,4,".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","Forms a IKK comples controling IKβ, the inhibitory binding partner of the NF-κB/Rel transcription factors. Activation of NF-κB commonly depends on phosphorylation-induced, proteasome-mediated degradation of IκB. The key regulatory step in this pathway involves activation of the IκB kinase (IKK) complex consiting of three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit.  Activation depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα)."]
["IKK alpha/beta - phospho","Ser176/Ser180","CHUK, IKBKB","87, 85","rb",null,4,4,".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .OXS., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR."," Activation depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα) leading to phosphorylation-induced, proteasome-mediated degradation of IκB relasing NF-κB/Rel transcription factors from inhibition."]
["IKK beta",null,"IKBKB","87","rb",null,1,1.1000000000000001,".ALZ., .AML., .APO., .BCR., .CANCER., .CANPTHW., .CD., .CML., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .FOXO., .HEPB., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INS., .INT., .MAPK., .MTOR., .NFKB., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TMAT., .TNF., .TOLL., .TRASR., .VIR.","Forms a IKK comples controling IKβ, the inhibitory binding partner of the NF-κB/Rel transcription factors. Activation of NF-κB commonly depends on phosphorylation-induced, proteasome-mediated degradation of IκB. The key regulatory step in this pathway involves activation of the IκB kinase (IKK) complex consiting of three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit.  Activation depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα)."]
["Jak1",null,"JAK1","130","rb",null,2.1,1.1000000000000001,".ANG., .CANCER., .CANPTHW., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DRAS., .EGFR., .HEPB., .IMUF., .IMUR., .INFG., .INFM., .OP., .OPA., .PAC., .PDGF., .PI3K., .RTK., .ST., .STAT., .TCD., .TMAT., .VIR.","Member of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. Involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Associated signaling proteins are Stats, Shc , IRS1/2 and FAK. Phosphorylation of JAK leads to phosphorylation/activation of STAT proteins which activate gene transcription potentially responsible for the transforming activity (esp.STAT3). ","Ruxolitinib"]
["Jak1 - phospho","Tyr1022/Tyr1023","JAK1","130","rb",null,2,2,".ANG., .CANCER., .CANPTHW., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DRAS., .EGFR., .HEPB., .IMUF., .IMUR., .INFG., .INFM., .OP., .OPA., .PAC., .PDGF., .PI3K., .RTK., .ST., .STAT., .TCD., .TMAT., .VIR.","Human Jak1 residues Tyr1034 and Tyr1035 (historicallyreferenced as Tyr1022 and Tyr1023) in the putative activation loop are the homologous tyrosine residues 1054/1055 in Tyk2, which are important in the regulation of Tyk2 kinase activity","Ruxolitinib"]
["Jak2 - phospho","Tyr1007/Tyr1008","JAK2","125","rb",null,2,2,".APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRAS., .EGFR., .GPCR., .GPROT., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PLAT., .RTK., .SREME., .ST., .STAT., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .VIR.","The tyrosine residues 1007/1008 of Jak2 in the putative activation loop are the homologous to  1054/1055 in Tyk2, which are important in the regulation of Tyk2 kinase activity.","Ruxolitinib, Erlotinib"]
["Jak2",null,"JAK2","125","rb",null,1,2,".APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRAS., .EGFR., .GPCR., .GPROT., .HEPB., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PLAT., .RTK., .SREME., .ST., .STAT., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .VIR.","Member of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. Involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Associated signaling proteins are Stats, Shc , IRS1/2 and FAK. Phosphorylation of JAK leads to phosphorylation/activation of STAT proteins which activate gene transcription potentially responsible for the transforming activity (esp.STAT3). ","Ruxolitinib, Erlotinib"]
["LRP6",null,"LRP6","210, 180","rb",null,1,2.1,".ALZ., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CP., .CSP., .CUR., .D300., .DEV., .DI., .DMTOR., .MTOR., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.","LRP6 is a single-pass transmembrane proteins that functions as co-receptors for Wnt and is required for the canonical Wnt/β-catenin signaling pathway. LRP5 and LRP6 are highly homologous and have redundant roles during development . Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1 allowing it to recruit axin to the membrane thus removing inhibition from and allowing for β-catenin signaling. The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins."]
["LRP6 - phospho","Ser1490","LRP6","210, 180","rb",null,4,4,".ALZ., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CP., .CSP., .CUR., .D300., .DEV., .DI., .DMTOR., .MTOR., .OP., .OPA., .OT., .RTK., .ST., .TRASR., .WNT.","LRP6 is a single-pass transmembrane proteins that functions as co-receptors for Wnt and is required for the canonical Wnt/β-catenin signaling pathway. LRP5 and LRP6 are highly homologous and have redundant roles during development . Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1 allowing it to recruit axin to the membrane thus removing inhibition from and allowing for β-catenin signaling. The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins."]
["Mcl-1",null,"MCL1","40, 35","rb",null,2,7,".APH., .APO., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .OPA., .PI3K., .RTK., .ST., .STAT.","Mcl-1 is an anti-apoptotic member of the Bcl-2 family. Mcl-1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl-2 family members, and inhibits apoptosis. Mcl-1 is rapidly transcribed via a PI3K/Akt dependent pathway, resulting in its increased expression during myeloid differentiation and cytokine stimulation. Mcl-1 is phosphorylated in response to treatment with phorbol ester, microtubule-damaging agents, oxidative stress, and cytokine withdrawal. Phosphorylation Thr163, conserved MAP kinase/ERK site, slows Mcl-1 protein turnover but may prime for destabilizing GSK-3 mediated phosphorylation at Ser159."]
["Mcl-1 - phospho","Ser159/Thr163","MCL1","42","rb",null,1,1,".APH., .APO., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .OPA., .PI3K., .RTK., .ST., .STAT."," Mcl-1 is phosphorylated in response to treatment with phorbol ester, microtubule-damaging agents, oxidative stress, and cytokine withdrawal. Phosphorylation Thr163, conserved MAP kinase/ERK site, slows Mcl-1 protein turnover but may prime for destabilizing GSK-3 mediated phosphorylation at Ser159."]
["MDM2 - phospho","Ser166","MDM2","90","rb",null,2,4,".APO., .BLC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .FOXO., .GLI., .HIF., .INS., .MEL., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SREME., .TRASR., .UBI.","MDM2, a E3 ubiquitin ligase, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53."]
["MEK1",null,"MAP2K1","45","rb",null,2,2,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Stimulation of this pathway, intiates a sequential three-part protein kinase cascade; MAPKKK or MAP3K >, MAPKK or MAP2K >MAPK.  MAP3Ks include members of the Raf family while the primary MAPKKs are MEK1/2 activate the MAPKs Erk1/2 through phosphorylation. Depending on the cellular context, this pathway mediates functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements.\nActivation occurs through phosphorylation of Ser218 and Ser222 by RAF proteins. MEK1 is also the target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MEK1 on Thr292, thereby facilitating dephosphorylation of the activating residues Ser218 and Ser222. MEK1 is inhibited by serine/threonine phosphatase 2A.","Trametinib, Cobimetinib, Bosutinib"]
["MEK1 - phospho","Ser298","MAP2K1","45","rb",null,1,1,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","In response to integrin signaling, p21-activated kinase-1 (PAK-1) phosphorylates MEK1 at Ser298, which enhances MEK1-ERK2 complex formation and MEK1 activation by Raf-1, positively regulating the Raf-1-MEK-ERK signaling cascade. RK2-dependent phosphorylation of MEK1 also attenuates its PAK-1-mediated phosphorylation, contributing to a reduction in Raf-dependent phosphorylation of residues within the MEK1 activation loop.","Trametinib, Cobimetinib, Bosutinib"]
["MEK1 - phospho","Thr286","MAP2K1","45","rb",null,2,2,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","MEK1 is also phosphorylated by cdk5 at Thr286 in mitotic cells, causing negative feedback of the p44/42 MAP kinase pathway","Trametinib, Cobimetinib, Bosutinib"]
["MEK1 - phospho","Thr292","MAP2K1","45","rb",null,1,1,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","ERK2-dependent phosphorylation of MEK1 at Thr292 negatively regulates MEK1 activation following cell adhesion. ","Trametinib, Cobimetinib, Bosutinib"]
["MEK1/2 - phospho","Ser217/Ser221","MAP2K1, MAP2K2","45","rb",null,2,1,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TNF., .TOLL., .TRASR., .TYR., .VEGFS.","Activation occurs through phosphorylation of Ser218 and Ser222 (Ser217, Ser221 Mek2) by RAF proteins. MEK1 is also the target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MEK1 on Thr292, thereby facilitating dephosphorylation of the activating residues Ser218 and Ser222. MEK1 is inhibited by serine/threonine phosphatase 2A.","Trametinib, Cobimetinib, Bosutinib"]
["MEK2",null,"MAP2K2","45","rb",null,2,2,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TD., .TMAT., .TOLL., .TRASR., .TYR., .VEGFS.","Dual specificity protein kinase which is a component of the MAP kinase signal transduction pathway. Stimulation of this pathway, intiates a sequential three-part protein kinase cascade; MAPKKK or MAP3K >, MAPKK or MAP2K >MAPK.  MAP3Ks include members of the Raf family while the primary MAPKKs are MEK1/2 activate the MAPKs Erk1/2 through phosphorylation. Depending on the cellular context, this pathway mediates functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements.\nActivation occurs through phosphorylation of Ser217 and Ser221 by RAF proteins. MEK1 is also the target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MEK1 on Thr292, thereby facilitating dephosphorylation of the activating residues Ser218 and Ser222. MEK1 is inhibited by serine/threonine phosphatase 2A.","Trametinib, Cobimetinib, Bosutinib"]
["c-Met (HGF/SF receptor) - phospho","Tyr1234/1235","MET","145","rb",null,4,4,".APH., .CAMET., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D300., .DRAS., .EGFR., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .NSCLC., .OP., .OPA., .OT., .PI3K., .RAS., .RCC., .RTK., .ST., .TRASR.","Phosphorylation at Tyr1234/1235 in the Met kinase domain is critical for kinase activation","Cabozantinib, Crizotinib, Brigatinib"]
["MMP-9",null,"MMP9","92, 84","rb",null,4,4,".ALZ., .APO., .BLC., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DI., .DRAS., .EGFR., .ErbB., .HEPB., .IMFR., .IMUR., .MIG., .OP., .OPA., .OT., .OXS., .PRC., .RTK., .SREME., .ST., .TNF.","The matrix metalloproteinases target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules. MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis."]
["Mnk1",null,"MKNK1","50","rb",null,2,2,".CSP., .CUR., .D100., .D200., .D300., .DRAS., .HIF., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .PDGF., .RTK., .SREME., .ST., .TRASR.","MAPK-interacting kinases (Mnk1 and Mnk2) are direct downstream substrates of MAPK. Both Mnks possess a MAPK-binding domain that allows them to bind to and then to be phosphorylated by Erk and p38. Phosphorylation  in mouse Mnk1 (Thr197 and Thr202) stimulates kinase activity and can cause Mnk1 to phosphorylate  eukaryotic initiation factor-4E (eIF4E) at Ser209, a key component of the translational machinery mediating the initiation of translation."]
["Mnk1 - phospho","Thr197/Thr202","MKNK1","50","rb",null,2,4,".CSP., .CUR., .D100., .D200., .D300., .DRAS., .HIF., .INS., .INT., .MAPK., .OP., .OPA., .OT., .OXS., .P38., .PDGF., .RTK., .SREME., .ST., .TRASR.","MAPK-interacting kinases (Mnk1 and Mnk2) are direct downstream substrates of MAPK. Both Mnks possess a MAPK-binding domain that allows them to bind to and then to be phosphorylated by Erk and p38. Phosphorylation  in mouse Mnk1 (Thr197 and Thr202) stimulates kinase activity and can cause Mnk1 to phosphorylate  eukaryotic initiation factor-4E (eIF4E) at Ser209, a key component of the translational machinery mediating the initiation of translation."]
["MSK1",null,"RPS6KA5","90","rb",null,2,4,".BLC., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D100., .D200., .D300., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PDGF., .RTK., .SREME., .ST., .TNF., .TRASR.","MSK1 is  a serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. \nActivated by phosphorylation at Ser360, Thr581 and Thr700 by ERK1/2 and MAPK14/p38-alpha, and by further autophosphorylation of Ser212, Ser376 and Ser381 by the activated C-terminal kinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as Ser750, Ser752 and Ser758 in its own C-terminal region. Is necessary for the Ser727 phosphorylation of STAT3; Phosphorylates ETV1/ER81 at Ser191 and Ser216 thereby regulating transcription, which may be important during development and breast tumor formation ). Directly represses transcription via phosphorylation of Ser1 of histone H2A . Phosphorylates Ser10 of histone H3 which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate Ser28 of histone H3."]
["MSK1 - phospho","Ser360","RPS6KA5","90","rb",null,2,2,".BLC., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D200., .D300., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PDGF., .RTK., .SREME., .ST., .TNF., .TRASR.","Activated by phosphorylation at Ser360, Thr581 and Thr700 by ERK1/2 and MAPK14/p38-alpha, and by further autophosphorylation of Ser212, Ser376 and Ser381 by the activated C-terminal kinase domain. "]
["MSK1 - phospho","Ser360","RPS6KA5","90","rb",null,2,2,".BLC., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D300., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PDGF., .RTK., .SREME., .ST., .TNF., .TRASR.","Activated by phosphorylation at Ser360, Thr581 and Thr700 by ERK1/2 and MAPK14/p38-alpha, and by further autophosphorylation of Ser212, Ser376 and Ser381 by the activated C-terminal kinase domain. "]
["MSK1 - phospho","Ser376","RPS6KA5","90","rb",null,2,1,".BLC., .CANCER., .CANPTHW., .CD., .CSP., .CUR., .D100., .D200., .D300., .DRAS., .IMFR., .IMUF., .IMUR., .INFM., .INS., .MAPK., .NFKB., .OP., .OPA., .OT., .P38., .PDGF., .RTK., .SREME., .ST., .TNF., .TRASR.","Activated by phosphorylation at Ser360, Thr581 and Thr700 by ERK1/2 and MAPK14/p38-alpha, and by further autophosphorylation of Ser212, Ser376 and Ser381 by the activated C-terminal kinase domain. "]
["mTOR - phospho","Ser2448","MTOR","289","rb",null,1,1,".ALZ., .AML., .AMPK., .APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .DMTOR., .EGFR., .GLI., .HIF., .HUNT., .IMFR., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PRC., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TRASR.","mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481","Everolimus, Temsirolimus"]
["mTOR",null,"MTOR","289","rb",null,2,1,".ALZ., .AML., .AMPK., .APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .DMTOR., .EGFR., .GLI., .HIF., .HUNT., .IMFR., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PRC., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TRASR.","Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival. Functions as part of 2 structurally and functionally distinct signaling complexes - mTORC1 and mTORC2. \nActivated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. Phosphorylation of EIF4EBP1 causes release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1.  mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. mTORC1 may phosphorylate CLIP1 and regulate microtubules.  \nmTORC2 complex may regulate  processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at Ser473 of AKT1,  facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at Ser422.\nActivation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity of mTORC1. Insulin-stimulated and amino acid-dependent phosphorylation at Ser1261 promotes autophosphorylation and the activation of mTORC1. On the other hand, low cellular energy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits  through a REDD1-dependent mechanism which may also require PRKAA1. The kinase activity of MTOR within the mTORC1 complex is positively regulated by MLST8 and negatively regulated by DEPTOR and AKT1S1.\nmTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. It may be regulated by RHEB but in an indirect manner through the PI3K signaling pathway.","Everolimus, Temsirolimus"]
["mTOR - phospho","Ser2481","MTOR","289","rb",null,4,4,".ALZ., .AML., .AMPK., .APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DMTOR., .EGFR., .GLI., .HIF., .HUNT., .IMFR., .IMUR., .INS., .INT., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PRC., .RTK., .SREME., .ST., .STAT., .TCD., .TMAT., .TRASR.","mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481","Everolimus, Temsirolimus"]
["p21 (CDKN1A) - phospho","Thr145","CDKN1A","21","rb",null,2,2,".APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .EGFR., .EMC., .FOXO., .GLI., .HEPB., .HIF., .IMUF., .INT., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR.","Akt-dependent phosphorylation of p21(Cip1) at Thr 145 prevents the complex formation of p21(Cip1) with PCNA,  a subunit of DNA polymerase, inhibiting DNA replication. In addition, phosphorylation of p21(Cip1) at Thr 145 decreases the binding of the cyclin-dependent kinases Cdk2 and Cdk4 to p21(Cip1) and attenuates the Cdk2 inhibitory activity of p21(Cip1)."]
["p21 (CDKN1A)",null,"CDKN1A","21","rb",null,1,4,".APO., .BCR., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DI., .EGFR., .EMC., .FOXO., .GLI., .HEPB., .HIF., .IMUF., .INT., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TRASR., .TYR.","p21 Waf1/Cip1 is and tumor supressor acting as an inhibitor of cell cycle progression.It forms heterotrimeric complexes with cyclins and cyclin-dependent kinases. In  CDK2 complexes, it inhibits kinase activity and blocks progression through G1/S. However, it may also enhance assembly and activity of CDK4/CDK6 and cyclin D complexes.  p21 transcription is upregulated via a p53-responsive element by phosphorylated p53 upon UV damage or during cell cycle  stages with active cdc2/cyclin B or CDK2/cyclin. "]
["p27-Kip1 (CDKN1B)",null,"CDKN1B","27","ms",null,1.1000000000000001,1,".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DRR., .EGFR., .FOXO., .HIF., .INT., .NOTCH., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR.","p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors enforcing the G1 restriction point due to inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression of p27 is upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by interleukin-2 or other mitogens involving phosphorylation of p27 and its degradation."]
["p27-Kip1 (CDKN1B) - phospho","Ser10","CDKN1B","22","rb",null,1.1000000000000001,1,".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DRR., .EGFR., .FOXO., .HIF., .INT., .NOTCH., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR.","Akt also phosphorylated p27(Kip1) at Ser10 and Thr187. Phosphorylation on Ser10 promotes cytoplasmic localization and is not a prerequisite for its proteolysis. G1 nuclear export of p27 and its Ser10 phosphorylation precede cyclin-dependent kinase 2 (Cdk2) activation and degradation of the bulk of p27.  Interestingly, phosphorylation at Ser10 can increases its protein stability."]
["p27-Kip1 (CDKN1B) - phospho","Thr187","CDKN1B","27","rb",null,2,2,".APO., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DRR., .EGFR., .FOXO., .HIF., .INT., .NOTCH., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR.","Akt also phosphorylated p27(Kip1) at Ser10 and Thr187. Phosphorylation promotes p27(Kip1) ubiquitination and degradation  by the SCF(Skp2) complex."]
["p53",null,"TP53","53","gt",null,1,6,".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","Tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process e.g  inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro."]
["p53 - phospho","Ser15","TP53","53","ms",null,3,2.1,".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","DNA damage induces phosphorylation of p53 at Ser15 and Ser20  promoting  accumulation by  reduced interaction between p53 and its negative regulator, MDM2 which inhibits p53 accumulation by targeting p53 for degradation. p53 can be phosphorylated by ATM, ATR, and DNA-PK at Ser15 and Ser37, promoting  both the accumulation and activation. "]
["p53 - phospho","Ser20","TP53","53","rb",null,2,4,".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","DNA damage induces phosphorylation of p53 at Ser15 and Ser20  promoting  accumulation by  reduced interaction between p53 and its negative regulator, MDM2 which inhibits p53 accumulation by targeting p53 for degradation. Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability, and activity."]
["p53 - phospho","Ser37","TP53","53","rb",null,1,4,".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","p53 can be phosphorylated by ATM, ATR, and DNA-PK at Ser15 and Ser37. Phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and activation of p53 in response to DNA damage."]
["p53 - phospho","Ser392","TP53","53","rb",null,4,4,".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","Phosphorylation of p53 at Ser392 (by CAK) is increased in human tumors and has been reported to influence the growth suppressor function, DNA binding, and transcriptional activation."]
["p53 - phospho","Ser46","TP53","53","rb",null,2,4,".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","Phosphorylation of p53 at Ser46 regulates the ability of p53 to induce apoptosis."]
["p53 - phospho","Ser46","TP53","53","rb",null,2,2.1,".APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DDR., .DEV., .DI., .DREP., .DRR., .EMC., .GLI., .HEPB., .HIF., .HUNT., .IMUF., .IMUR., .INFG., .INFM., .MAPK., .MEL., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PI3K., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TCD., .TCR., .TGFB., .TMAT., .TNF., .TRASR., .TYR., .VIR., .WNT.","Phosphorylation of p53 at Ser46 regulates the ability of p53 to induce apoptosis."]
["p70 S6 kinase",null,"RPS6KB1","85, 70","rb",null,1,1,".AML., .AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRR., .EGFR., .HIF., .IIR., .IMUR., .INS., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .RAS., .RTK., .SREME., .ST., .TGFB., .TRASR.","p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression.  A second isoform, p85 S6 kinase, is derived from the same gene and is identical to p70 S6 kinase except for 23 extra residues at the amino terminus, which encode a nuclear localizing signal. Acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by mTORC1 leads to dissociation from the EIF3 complex and activation. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. \nActivation appears to be first mediated by phosphorylation of multiple sites in the autoinhibitory domain, which facilitates phosphorylation at Thr412, disrupting the autoinhibitory mechanism and allowing phosphorylation of Thr252 by PDPK1. The active conformation is stabilized by a mechanism involving three conserved phosphorylation sites located in the kinase domain activation loop (Thr252) and in the AGC-kinase C-terminal domain (Ser394, Thr412). "]
["p70 S6 kinase - phospho","Thr389","RPS6KB1","85, 70","rb",null,2.1,8,".AML., .AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRR., .EGFR., .HIF., .IIR., .IMUR., .INS., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .RAS., .RTK., .SREME., .ST., .TGFB., .TRASR.","Activation appears to be first mediated by phosphorylation of multiple sites in the autoinhibitory domain, which facilitates phosphorylation at Thr412, disrupting the autoinhibitory mechanism and allowing phosphorylation of Thr252 by PDPK1. The active conformation is stabilized by a mechanism involving three conserved phosphorylation sites located in the kinase domain activation loop (Thr252) and in the AGC-kinase C-terminal domain (Ser394, Thr412). Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function. Phosphorylation of Thr389, however, most closely correlates with p70 kinase activity in vivo. Prior phosphorylation of Thr389 is required for the action of PDPK1 on Thr229."]
["p70 S6 kinase - phospho","Thr421/Ser424","RPS6KB1","85, 70","rb",null,2,2,".AML., .AMPK., .APH., .APO., .BRC., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRR., .EGFR., .HIF., .IIR., .IMUR., .INS., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .RAS., .RTK., .SREME., .ST., .TGFB., .TRASR.","Ser411, Thr421 and Ser424 phosphorylation  is thought to activate p70 S6 kinase via relief of pseudosubstrate suppression."]
["RSK 1/3 - phospho","Thr359/Ser363","RPS6KA1, RPS6KA2","90","rb",null,4,4,".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and PI3k in response to many growth factors, polypeptide hormones, and neurotransmitters. Upon mitogenic stimulation, p44/42 Erk1/2 and Erk5 MAP kinases cooperatively phosphorylate p90RSK at Thr573 (p90RSK1 numbering) located within the C-terminal kinase domain and at Thr359/Ser363 in the linker region between the two kinase domains."]
["PDGF receptor beta",null,"PDGFRB","190","rb",null,1,7,".ANG., .APO., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .GLI., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT.","Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Binding of its cognate ligands leads to the activation of several signaling cascades. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of DAG  and IP3, mobilization of cytosolic Ca2+ and the activation of PKCs. Phosphorylation of PIK3R1, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1 or PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases (e.g. Erk1/2). Promotes phosphorylation of PDCD6IP/ALIX and STAM and phosphorylation and activation of SRC family kinases. ","Pazopanib, Sunitinib, Axitinib, Azacitidine, Imatinib, Dasatinib, Olaratumab, Midostaurin, Regorafenib, Ponatinib"]
["PDGF receptor beta - phospho","Tyr751","PDGFRB","190","rb",null,4,4,".ANG., .APO., .CAMET., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DRAS., .EGFR., .GLI., .GPCR., .GPROT., .MAPK., .MEL., .MIG., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PRC., .RAS., .RTK., .SREME., .ST., .STAT.","Tyr751 in the kinase-insert region of PDGFRβ is the docking site for PI3 kinase , leading to the activation of the AKT1 signaling pathway. Phosphorylation at  Tyr740 is also required for PDGFRβ-mediated PI3 kinase activation.","Pazopanib, Sunitinib, Axitinib, Azacitidine, Imatinib, Dasatinib, Olaratumab, Midostaurin, Regorafenib, Ponatinib"]
["PDK1",null,"PDK1","68-58","rb",null,2,2.1,".APO., .CAMET., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .HIF., .OP., .OPA., .SREME., .ST.","Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: PKB(AKT1, AKT2, AKT3), p70S6K(RPS6KB1), p90RSK(RPS6KA1, RPS6KA2 and RPS6KA3), PRKACA, PKC (PRKCD and PRKCZ), SGK1, SGK2 and SGK3, p21-activated kinase-1 (PAK1), and PKN1 and PKN2. Activates the NF-kappa-B pathway via phosphorylation of IKKB. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta.\nHomodimerization regulates its activity by maintaining the kinase in an autoinhibitory conformation. NPRL2 down-regulates its activity by interfering with tyrosine phosphorylation at the Tyr-9, Tyr-373 and Tyr-376 residues. The 14-3-3 protein YWHAQ acts as a negative regulator by association with the residues surrounding the Ser-241 residue. STRAP positively regulates its activity by enhancing its autophosphorylation and by stimulating its dissociation from YWHAQ. SMAD2, SMAD3, SMAD4 and SMAD7 also positively regulate its activity by stimulating its dissociation from YWHAQ. Activated by phosphorylation on Tyr-9, Tyr-373 and Tyr-376 by INSR in response to insulin."]
["PDK1 - phospho","Ser241","PDK1","68-58","rb",null,2,2,".APO., .CAMET., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .HIF., .OP., .OPA., .SREME., .ST.","Phosphorylation on the activation loop Ser241 by autophosphorylation is necessary for PDK1 activity"]
["PI3 Kinase p101",null,"PIK3R5","101","rb",null,2,4,".CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .EGFR., .ENDO., .GPCR., .GPROT., .IMU., .IMUR., .INS., .MAPK., .OP., .OPA., .OT., .P53S., .PDGF., .PI3K., .PLAT., .RTK., .SREME.","Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG"]
["PI3 Kinase p110 gamma",null,"PIK3CG","110","rb",null,2,4,".ANG., .APO., .BCR., .cAMP., .CANCER., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .HIF., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P53S., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .VEGFS.","Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. \nIs activated by both the alpha and the beta-gamma G proteins following stimulation of G protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunits (PIK3R5 or PIK3R6) leading to the translocation from the cytosol to the plasma membrane and to kinase activation."]
["PI3 Kinase p110 delta",null,"PIK3CD","110","rb",null,2,6,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","Aktivated by RTK Signaling, Class1A; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology.  Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function and is  required for B-cell receptor (BCR) signaling. Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.","Idelalisib, Copanlisib"]
["PI3 Kinase p110 gamma",null,"PIK3CG","110","ms",null,1,4,".ANG., .APO., .BCR., .cAMP., .CANCER., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .EGFR., .ENDO., .FGFR., .GPCR., .GPROT., .HIF., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P53S., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TRASR., .VEGFS.","Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. \nIs activated by both the alpha and the beta-gamma G proteins following stimulation of G protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunits (PIK3R5 or PIK3R6) leading to the translocation from the cytosol to the plasma membrane and to kinase activation."]
["PI3 Kinase p110 alpha",null,"PIK3CA","110","rb",null,2,7,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMUF., .INFM., .INS., .INT., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","Aktivated by RTK Signaling, Class1A; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Activation upon stimulation by RTKS ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins:","Copanlisib"]
["PI3 Kinase p110 beta",null,"PIK3CB","110","ms",null,2,8,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FGFR., .FOXO., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .OXS., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","Aktivated by RTK Signaling, Class1A; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors."]
["PI3 Kinase p85 alpha",null,"PIK3R1","85","rb",null,2,2,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CCKR., .CD., .CML., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMU., .IMUF., .IMUR., .INS., .INT., .LMIG., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","Regulatory Subunit for Class1A; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling  Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2."]
["PI3 Kinase p85/p55 - phospho","p85 Tyr458/ p55 Tyr199","PIK3R3","85, 60","rb",null,2,6,".ALZ., .AML., .AMPK., .ANG., .APH., .APO., .BCR., .BRC., .CAMET., .cAMP., .CANCER., .CANPTHW., .CD., .CML., .CRC., .CSP., .CUR., .D200., .D300., .DAKT., .DI., .DMTOR., .EGFR., .EMC., .ENDO., .FOXO., .GLI., .GPCR., .HEPB., .HIF., .IMU., .IMUF., .IMUR., .INS., .INT., .MEL., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PLAT., .PRC., .RAS., .RCC., .RTK., .SCLC., .SREME., .ST., .STAT., .TCR., .TNF., .TOLL., .TRASR., .VEGFS.","Regulatory Subunit for Class1A; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling  Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2. Role of Phoyphoryltaion currently unkonwn."]
["PKA C alpha",null,"PRKACA","42","rb",null,1,1,".APH., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D200., .D300., .DEV., .DRAS., .ENDO., .GPCR., .GPROT., .HHSP., .IMUF., .INFM., .INS., .MAPK., .OP., .OPA., .OT., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .WNT.","cAMP-dependent protein kinase catalytic subunit alpha is a subunit  of PKA (cAPK) which controls mechanisms such as gene transcription, ion transport, and protein phosphorylation . Inactive PKA is a heterotetramer composed of a regulatory subunit (R) dimer and a catalytic subunit (C) dimer.In this inactive state, the pseudosubstrate sequences on the R subunits block the active sites on the C subunits. Three C subunit isoforms (C-α, C-β, and C-γ); two families of regulatory subunits (RI and RII).\nPKA phosphorylates a large number of substrates in the cytoplasm and the nucleus and shares some substrate specificity with Akt (PKB) and PKC. Substrates twith consensus sequenceare Bad (Ser155), CREB (Ser133), and GSK-3 (GSK-3α Ser21 and GSK-3β Ser9) . In addition, combined knock-down of PKA C-α and -β blocks cAMP-mediated phosphorylation of Raf (Ser43 and Ser259).","Midostaurin"]
["PKA C alpha/beta/gamma - phospho","Thr197","PRKACA, PRKACB, PRKACG","42","rb",null,2,4,".APH., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D200., .D300., .DEV., .DRAS., .ENDO., .GPCR., .GPROT., .HHSP., .IMUF., .INFM., .INS., .MAPK., .OP., .OPA., .OT., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .WNT.","cAMP-dependent protein kinase catalytic subunits are subunit  of PKA (cAPK) which controls many cellular mechanisms such as gene transcription, ion transport, and protein phosphorylation. Three C subunit isoforms (C-α, C-β, and C-γ. Autophosphorylation and phosphorylation by PDK-1 are two known mechanisms responsible for phosphorylation of the C subunit at Thr197 which is required for optimal enzyme activity.","Midostaurin"]
["PKC (pan) - phospho","Ser660","PRKCA, PRKCB, PRKCD, PRKCE, PRKCH, PRKCQ","85, 82, 80, 78","rb",null,1,2,".ALZ., .ANG., .APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DRR., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .MAPK., .MIG., .MTOR., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .TOLL., .TRASR., .UBI., .VEGFS., .WNT.","Phosphorylation occurs at Thr500(Thr497) in the activation loop, at Thr641(Thr638) through autophosphorylation, and at the carboxy-terminal hydrophobic site Ser660(Ser657). mTORC2 also modulates the phosphorylation of PRKCA on Ser657 and may effekt intracellular localization. All three sites need to be phosphorylated for its full activation.","Midostaurin"]
["PKC (pan) gamma - phospho","Thr514","PRKCA, PRKCB, PRKCD, PRKCE, PRKCH, PRKCG, PRKCQ","85, 82, 80, 78","rb",null,1,2,".ALZ., .ANG., .APH., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DDR., .DEV., .DI., .DMTOR., .DRAS., .DREP., .DRR., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .MAPK., .MIG., .MTOR., .NFKB., .NSCLC., .OP., .OPA., .OT., .OXS., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .TOLL., .TRASR., .UBI., .VEGFS., .WNT.","Thr514-phosphorylation of de novo synthesized PKCgamma by PDK1 is the first step in priming of the inactive PKCgamma before its release into the cytoplasm.","Midostaurin"]
["PKC alpha",null,"PRKCA","82","ms",null,1.1000000000000001,1,".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .MAPK., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","The Protein Kinase C (PKC) family  (typical α, β, and γ isoforms; atypical ζ, ι, and λ isoforms; novel novel (δ, ε, η and θ) of homologous serine/threonine protein kinases is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation. It phosphorylattes  targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activates signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.\nConventional PKCs are activated in response to increased concentrations of intracellular Ca2+ and DAG, novel PKCs are Ca2+-independent but DAG-dependent, and atypical PKCs are both, Ca2+- and DAG-independent. Three specific sites; Thr-497 (activation loop of the kinase domain), Thr-638 (turn motif) and Ser-657 (hydrophobic region), need to be phosphorylated for its full activation.","Midostaurin"]
["PKC alpha - phospho","Ser657","PRKCA","77","rb",null,2,1,".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .MAPK., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Phosphorylation occurs at Thr500(Thr497) in the activation loop, at Thr641(Thr638) through autophosphorylation, and at the carboxy-terminal hydrophobic site Ser660(Ser657). mTORC2 also modulates the phosphorylation of PRKCA on Ser657 and may effekt intracellular localization. All three sites need to be phosphorylated for its full activation.","Midostaurin"]
["PKC alpha - phospho","Thr497","PRKCA","77","rb",null,1,1,".ALZ., .ANG., .APO., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .MAPK., .MIG., .MTOR., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Phosphorylation occurs at Thr500(Thr497) in the activation loop, at Thr641(Thr638) through autophosphorylation, and at the carboxy-terminal hydrophobic site Ser660(Ser657). mTORC2 also modulates the phosphorylation of PRKCA on Ser657 and may effekt intracellular localization. All three sites need to be phosphorylated for its full activation.","Midostaurin"]
["PKC alpha/beta II - phospho","Thr638/Thr641","PRKCA, PRKCB","82, 80","rb",null,1,1,".ALZ., .ANG., .APO., .BCR., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .ENDO., .FGFR., .GLI., .GPCR., .GPROT., .HEPB., .HIF., .IMU., .IMUF., .IMUR., .INFM., .INS., .MAPK., .MIG., .MTOR., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TRASR., .VEGFS., .WNT.","Phosphorylation occurs at Thr500(Thr497) in the activation loop, at Thr641(Thr638) through autophosphorylation, and at the carboxy-terminal hydrophobic site Ser660(Ser657). mTORC2 also modulates the phosphorylation of PRKCA on Ser657 and may effekt intracellular localization. All three sites need to be phosphorylated for its full activation.","Midostaurin"]
["PLC gamma 1 - phospho","Ser1248","PLCG1","150","rb",null,1,1.1000000000000001,".ANG., .CANCER., .CANPTHW., .CCKR., .CCP., .CP., .CSP., .CUR., .D200., .D300., .DRAS., .EGFR., .FGFR., .GLI., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .VEGFS.","PLCγ is activated by both receptor and nonreceptor tyrosine kinases; it forms a complex with EGF and PDGF receptors, which leads to the phosphorylation at Tyr771, 783 and 1248 . Phosphorylation by Syk at Tyr783 activates its enzymatic activity."]
["PLC gamma 1",null,"PLCG1","155","rb",null,1,2,".ANG., .CANCER., .CANPTHW., .CCKR., .CCP., .CP., .CSP., .CUR., .D200., .D300., .DRAS., .EGFR., .FGFR., .GLI., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .VEGFS.","Phosphoinositide-specific phospholipase C (PLC) mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Becomes activated in response to ligand-mediated activation of RTKs, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. t least four families of PLCs have been identified: PLCβ, PLCγ, PLCδ and PLCε. The PLCβ subfamily includes four members, PLCβ1-4.\nPLCγ is activated by both receptor and nonreceptor tyrosine kinases; it forms a complex with EGF and PDGF receptors, which leads to the phosphorylation at Tyr771, 783 and 1248 . Phosphorylation by Syk at Tyr783 activates its enzymatic activity."]
["PLC gamma 1 - phospho","Tyr783","PLCG1","155","rb",null,4,4,".ANG., .CANCER., .CANPTHW., .CCKR., .CCP., .CP., .CSP., .CUR., .D200., .D300., .DRAS., .EGFR., .FGFR., .GLI., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .MIG., .NFKB., .NSCLC., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TCD., .TCR., .TMAT., .VEGFS.","PLCγ is activated by both receptor and nonreceptor tyrosine kinases; it forms a complex with EGF and PDGF receptors, which leads to the phosphorylation at Tyr771, 783 and 1248 . Phosphorylation by Syk at Tyr783 activates its enzymatic activity."]
["PP2A C alpha/beta",null,"PPP2CA, PPP2CB","38, 36","rb",null,1,1,".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .EGFR., .FGFR., .HIPPO., .IMUF., .INFM., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .RAS., .RTK., .SREME., .ST., .STAT., .TGFB., .TNF., .TRASR., .WNT.","PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser259.  It regulates fundamental cellular activities such as DNA replication, transcription, translation, metabolism, cell cycle progression, cell division, apoptosis and development. The core enzyme consists of catalytic C and regulatory A subunits."]
["PP2A C / PP4 - phospho","Tyr307","PPP2CA","36","rb",null,2,2,".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .EGFR., .FGFR., .HIPPO., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .SREME., .ST., .STAT., .TGFB., .TRASR., .WNT.","Phosphorylation of PP2A at Tyr307 by Src occurs in response to EGF or insulin and results in a substantial reduction of PP2A activity  and reduces its ability to bind to proteins such as CD28 and the glutamate receptor GluR5. Phosphorylation of PP2A at Y307 is highest during M-phase and lowest during S-phase of the cell cycle. Transient PP2A phosphorylation at this site is also observed in growth factor-stimulated cells."]
["PRAS40",null,"AKT1S1","40","rb",null,1,1,".AMPK., .APH., .APO., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OPA., .RTK., .SREME., .ST.","Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. PRAS40 is a known Akt substrate that binds mTOR to transduce Akt signals to the mTOR complex 1. Inhibition of mTOR signaling stimulates PRAS40 binding to mTOR, which in turn inhibits mTOR activity. It interacts with raptor within mTORC1 in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. mTORC1 in turn phosphorylates PRAS40 at Ser183."]
["PRAS40 - phospho","Ser183","AKT1S1","40","rb",null,2,1.1000000000000001,".AMPK., .APH., .APO., .CCKR., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OPA., .RTK., .SREME., .ST.","Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. PRAS40 is a known Akt substrate that binds mTOR to transduce Akt signals to the mTOR complex 1. Inhibition of mTOR signaling stimulates PRAS40 binding to mTOR, which in turn inhibits mTOR activity. It interacts with raptor within mTORC1 in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. mTORC1 in turn phosphorylates PRAS40 at Ser183."]
["PRAS40 - phospho","Thr246","AKT1S1","40","rb",null,1,4,".AMPK., .APH., .APO., .CCKR., .CD., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .MTOR., .OPA., .RTK., .SREME., .ST.","Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. PRAS40 is a known Akt substrate that binds mTOR to transduce Akt signals to the mTOR complex 1. Inhibition of mTOR signaling stimulates PRAS40 binding to mTOR, which in turn inhibits mTOR activity. It interacts with raptor within mTORC1 in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. mTORC1 in turn phosphorylates PRAS40 at Ser183."]
["PTEN",null,"PTEN","54","rb",null,2,2,".APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .EGFR., .EMC., .FOXO., .GLI., .HIF., .IMUF., .INFM., .INS., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR., .WNT.","Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase for PIP3,2,1 and IP4. PTEN is a major negative regulator of the PI3K/Akt signaling pathway. PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity.PTEN regulates p53 protein levels and activity and is involved in G protein-coupled signaling during chemotaxis."]
["PTEN - phospho","Ser380","PTEN","54","rb",null,2,2,".APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .EGFR., .EMC., .FOXO., .GLI., .HIF., .IMUF., .INFM., .INS., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR., .WNT.","Phosphorylation of PTEN at residues Ser380/Thr382/383 leads to loss of phosphatase activity and tumor suppressor function. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. "]
["PTEN - non-phospho","Ser380/Thr382/Thr383","PTEN","55","rb",null,1,1.1000000000000001,".APH., .APO., .BRC., .CAMET., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .EGFR., .EMC., .FOXO., .GLI., .HIF., .IMUF., .INFM., .INS., .MAPK., .MEL., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .PRC., .RTK., .SCLC., .SREME., .ST., .TRASR., .WNT.","Phosphorylation of PTEN at residues Ser380/Thr382/383 leads to loss of phosphatase activity and tumor suppressor function. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. "]
["Rac1/cdc42",null,"RAC1, CDC42","21","rb",null,1,1,".BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .EGFR., .FGFR., .GPCR., .GPROT., .HUNT., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .PAC., .PI3K., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TOLL., .TRASR., .UBI., .VEGFS., .WNT.","Rac and Cdc42 are members of the Rho-GTPase family. In mammals, Rac exists as three isoforms, Rac1, Rac2 and Rac3, which are highly similar in sequence. Rac1 and Cdc42, are ubiquitously expressed.  Rac and Cdc42 play key signaling roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation, cell growth and development"]
["Rac1/cdc42 - phospho","Ser71","RAC1, CDC42","28","rb",null,2,1.1000000000000001,".BCR., .cAMP., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CP., .CRC., .CSP., .CUR., .D300., .DAKT., .DEV., .DI., .EGFR., .FGFR., .GPCR., .GPROT., .HUNT., .IIR., .IMFR., .IMUF., .IMUR., .INFM., .INT., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .PAC., .PI3K., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TOLL., .TRASR., .UBI., .VEGFS., .WNT.","A putative Akt phosphorylation site at Ser71 of Rac1/cdc42 has been identified and confirme. Phosphorylation at this site may inhibit GTP binding of Rac1, attenuating the signal transduction pathway downstream of Rac1"]
["Raptor",null,"RPTOR","150","rb",null,2,1.1000000000000001,".AMPK., .APH., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DDR., .DMTOR., .DRR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TRASR.","Involved in the control of mTORC1 activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates,  including 4E-BP1 and p70 S6 kinase,  and  is required for mTOR-mediated phosphorylation of these substrates."]
["Raptor - phospho","Ser792","RPTOR","150","rb",null,2,2,".AMPK., .APH., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DDR., .DMTOR., .DRR., .HIF., .INS., .MTOR., .OP., .OPA., .OT., .PI3K., .RTK., .SREME., .ST., .TRASR.","AMPK phosphorylates raptor on Ser722/Ser792, essential for inhibition of the raptor-containing mTORC1 and induces cell cycle arrest when cells are stressed for energy."]
["Ras",null,"KRAS","21","rb",null,1,2,".ALZ., .AML., .ANG., .APH., .APO., .BCR., .BLC., .BRC., .CAMET., .CANCER., .CANPTHW., .CCP., .CD., .CML., .CP., .CRC., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DMTOR., .DRAS., .EGFR., .EMC., .FGFR., .FOXO., .GLI., .HEPB., .IMUF., .INFM., .INS., .INT., .MAPK., .MEL., .MTOR., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PDGF., .PI3K., .PRC., .RAS., .RCC., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .TYR., .VEGFS.","Ras Familiy proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms and are activated by RTKs and GPCRs, which then stimulate the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras, however, in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway"]
["Rb",null,"RB1","110","ms",null,2,4,".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo."]
["Rb - phospho","Ser608","RB1","110","rb",null,2,4,".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","Inhibits E2FTD binding. Phosphorylation of Rb at S608 depends on CDK4."]
["Rb - phospho","Ser780","RB1","110","rb",null,1.1000000000000001,4,".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","cyclin D1 is required for Ser780 phosphorylation in vivo; apoptosis inhibited"]
["Rb - phospho","Ser795","RB1","110","rb",null,2,4,".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","activity inhibited, cell growt induced"]
["Rb - phospho","Ser807/Ser811","RB1","110","rb",null,2,4,".APO., .BLC., .BRC., .CANCER., .CANPTHW., .CCP., .CCY., .CD., .CML., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DI., .DRR., .GLI., .HEPB., .HHSP., .IMFR., .IMUR., .INS., .MEL., .NSCLC., .OP., .OPA., .OT., .P53S., .PAC., .PRC., .RAS., .RTK., .SCLC., .SREME., .ST., .TRASR.","Ser-807/811 phosphorylation is required to disrupt c-Abl binding"]
["REDD1",null,"DDIT4","28","rb",null,4,4,".APH., .APO., .CD., .CSP., .CUR., .D300., .DMTOR., .HIF., .IMUR., .MIG., .MTOR., .OP., .OPA., .OT., .OXS., .P53S., .PI3K., .RTK., .SREME., .ST., .VIR.","REDD1 (REgulated in Development and DNA damage responses) expression is induced by hypoxia, cell stress, apoptosis and DNA damage. REDD1 is a transcriptional target of p53 and p63 following DNA damage, and links p63 to Ros.  Regulates cell growth, proliferation and survival via inhibition of the activity mTORC1 complex. Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity."]
["RHEB",null,"RHEB","20","rb",null,1,1,".AMPK., .APH., .CCKR., .CCP., .CCY., .CD., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST.","Ras Homolog Enriched in Brain (Rheb) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins. Rheb triggers activation of the Raf-MEK-MAPK pathway. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling.  Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity. The tuberin/hamartin (TSC2/TSC1) complex inhibits mTOR activity indirectly by inhibiting Rheb through the tuberin GAP activity."]
["Rictor",null,"RICTOR","200","rb",null,1,2.1,".APO., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DMTOR., .IMFR., .IMUR., .MTOR., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 plays a critical role in AKT1 Ser473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser422. mTORC2 also modulates the phosphorylation of PRKCA on Ser657. Plays an essential role in embryonic growth and development"]
["Rictor - phospho","Thr1135","RICTOR","200","rb",null,4,2.1,".APO., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DMTOR., .IMFR., .IMUR., .MTOR., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Phosphorylation of Rictor at Thr1135 by p70 S6K, which negatively regulates mTORC2 protein complex, may be part of a negative feedback mechanism controlling Akt activity."]
["RSK 1 - phospho","Ser380","RPS6KA1","90","rb",null,1,2,".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and PI3K in response to many growth factors, polypeptide hormones, and neurotransmitters. Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573/570/577 in the C-terminal kinase domain (CTKD) by ERK1/2. The activated CTKD then autophosphorylates Ser380/377/386, allowing binding of PDPK1, which in turn phosphorylates Ser221/218/227 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD."]
["RSK 1 - phospho","Thr573","RPS6KA1","83","rb",null,1,1,".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and PI3K in response to many growth factors, polypeptide hormones, and neurotransmitters. Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573/570/577 in the C-terminal kinase domain (CTKD) by ERK1/2. The activated CTKD then autophosphorylates Ser380/377/386, allowing binding of PDPK1, which in turn phosphorylates Ser221/218/227 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD."]
["RSK 1/2/3",null,"RPS6KA1, RPS6KA3, RPS6KA2","90","rb",null,2,2,".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases that act downstream of ERK1/2 signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77. Regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. Insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. \nUpon extracellular signal or mitogen stimulation, phosphorylated at Thr-573/570/577 in the C-terminal kinase domain (CTKD) by Erk1/2. The activated CTKD then autophosphorylates Ser380/377/386, allowing binding of PDPK1, which in turn phosphorylates Ser221/218/227 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD."]
["RSK 3",null,"RPS6KA2","90","rb",null,2,2,".APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases that act downstream of ERK1/2 signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77. Regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. Insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at Ser-9 and inhibiting its activity. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at Ser1798, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. \nUpon extracellular signal or mitogen stimulation, phosphorylated at Thr-573/570/577 in the C-terminal kinase domain (CTKD) by Erk1/2. The activated CTKD then autophosphorylates Ser380/377/386, allowing binding of PDPK1, which in turn phosphorylates Ser221/218/227 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD."]
["RSK 3 - phospho","Thr356/Ser360","RPS6KA2","90","rb",null,1,1.1000000000000001,".APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DMTOR., .DRAS., .INS., .INT., .MAPK., .MTOR., .OP., .OPA., .OT., .PDGF., .RAS., .RTK., .SREME., .ST., .TRASR.","RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and PI3k in response to many growth factors, polypeptide hormones, and neurotransmitters. Upon mitogenic stimulation, p44/42 Erk1/2 and Erk5 MAP kinases cooperatively phosphorylate p90RSK at Thr573 (p90RSK1 numbering) located within the C-terminal kinase domain and at Thr359/Ser363 in the linker region between the two kinase domains."]
["S6 ribosomal protein",null,"RPS6","32","rb",null,2,1,".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .EGFR., .HIF., .IMUF., .INS., .MTOR., .OP., .OPA., .PI3K., .RTK., .SREME., .TCR.","Growth factors and mitogens induce the activation of p70 S6 kinase and the subsequent phosphorylation of  RPS6. Phosphorylation RPS6 correlates with an increase in translation of mRNA transcripts that contain an oligopyrimidine tract in their 5' untranslated regions which encode proteins involved in cell cycle progression, ribosomal proteins and elongation factors necessary for translation"]
["S6 ribosomal protein - phospho","Ser235/Ser236","RPS6","32","rb",null,2,1,".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .EGFR., .HIF., .IMUF., .INS., .MTOR., .OP., .OPA., .PI3K., .RTK., .SREME., .TCR.","Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244)."]
["S6 ribosomal protein - phospho","Ser240/Ser244","RPS6","32","rb",null,1,1,".APO., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .EGFR., .HIF., .IMUF., .INS., .MTOR., .OP., .OPA., .PI3K., .RTK., .SREME., .TCR.","Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244)."]
["SGK1",null,"SGK1","60-45","rb",null,2,2,".APO., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DMTOR., .FOXO., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .ST., .TRASR.","Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation. In addition to its membrane channel and carrier functions, SGK1 also regulates a broad range of targets, such as GSK-3, NEDD4, iNOS, AMPAR, PSD95, Tau, NF-κB, CREB, and FKHR-L1. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity.  Phosphorylates ERK2 and activates it by enhancing its interaction MEK1/2. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. \nTwo specific sites, one in the kinase domain Thr256 and the other in the C-terminal regulatory region Ser422, need to be phosphorylated for its full activation. Phosphorylation at Ser397 and Ser401 are also essential for its activity. Activated by WNK1, WNK2, WNK3 and WNK4"]
["SGK1 - phospho","Ser78","SGK1","54","rb",null,1,4,".APO., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DDR., .DMTOR., .FOXO., .MIG., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .ST., .TRASR.","The MAP kinase family member BMK1 interacts with and activates SGK by phosphorylation at serine 78"]
["SGK3",null,"SGK3","61","rb",null,1,2,".APO., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .FOXO., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. SGK3 has been shown to be a downstream signaling molecule in the PI3K pathway. Two specific sites, one in the kinase domain Thr320 and the other in the C-terminal regulatory region Ser486, need to be phosphorylated for its full activation. Its activation and phosphorylation at Thr320 by PDK1 has been suggested to be an Akt-independent manner of signaling in cancer."]
["SGK3 - phospho","Thr320","SGK3","62","rb",null,2,6,".APO., .CCP., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DMTOR., .FOXO., .MIG., .OP., .OPA., .OT., .PI3K., .RTK., .ST., .TRASR.","SGK3 has been shown to be a downstream signaling molecule in the PI3K pathway. Two specific sites, one in the kinase domain Thr320 and the other in the C-terminal regulatory region Ser486, need to be phosphorylated for its full activation. Its activation and phosphorylation at Thr320 by PDK1 has been suggested to be an Akt-independent manner of signaling in cancer."]
["Src",null,"SRC","60","rb",null,2,1,".ANG., .APH., .APO., .BLC., .CADH., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .ErbB., .GPCR., .GPROT., .HEPB., .HIF., .HIPPO., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PARK., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .VEGFS., .VIR., .WNT.","Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult.\nPhosphorylation by CSK at Tyr530 inhibits kinase activity. Inhibitory phosphorylation at Tyr530 is enhanced by heme. Further phosphorylation by CDK1 partially reactivates CSK-inactivated SRC and facilitates complete reactivation by protein tyrosine phosphatase PTPRC. Integrin engagement stimulates kinase activity. Phosphorylation by PTK2/FAK1 enhances kinase activity. Phosphorylation at Tyr-419 increases kinase activity.","Neratinib, Dasatinib, Midostaurin, Bosutinib, Ponatinib"]
["Src - phospho","Ser17","SRC","60","rb",null,2,4,".ANG., .APH., .APO., .BLC., .CADH., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .ErbB., .GPCR., .GPROT., .HEPB., .HIF., .HIPPO., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PARK., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .VEGFS., .VIR., .WNT.","PKA-dependent phosphorylation of Src at Ser17 influences multiple signaling networks. This site has also been identified in a phospho-proteomic screen for substrates of mTOR.","Neratinib, Dasatinib, Midostaurin, Bosutinib, Ponatinib"]
["Src - phospho","Tyr527","SRC","60","rb",null,2,1,".ANG., .APH., .APO., .BLC., .CADH., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .ErbB., .GPCR., .GPROT., .HEPB., .HIF., .HIPPO., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PARK., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .VEGFS., .VIR., .WNT.","Phosphorylation by CSK at Tyr530(Tyr527) inhibits kinase activity. Inhibitory phosphorylation at Tyr530 is enhanced by heme. Further phosphorylation by CDK1 partially reactivates CSK-inactivated SRC and facilitates complete reactivation by protein tyrosine phosphatase PTPRC. Integrin engagement stimulates kinase activity. Phosphorylation by PTK2/FAK1 enhances kinase activity. Phosphorylation at Tyr-419 increases kinase activity.","Neratinib, Dasatinib, Midostaurin, Bosutinib, Ponatinib"]
["Src family - phospho","Tyr416","SRC","60","rb",null,2,1,".ANG., .APH., .APO., .BLC., .CADH., .CANCER., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .DRR., .EGFR., .ErbB., .GPCR., .GPROT., .HEPB., .HIF., .HIPPO., .IIR., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .LMIG., .MAPK., .MIG., .NOTCH., .OP., .OPA., .OT., .OXS., .PARK., .PDGF., .PI3K., .PLAT., .RAS., .RTK., .SREME., .ST., .TCR., .TGFB., .TRASR., .VEGFS., .VIR., .WNT.","Phosphorylation by CSK at Tyr530 inhibits kinase activity. Inhibitory phosphorylation at Tyr530 is enhanced by heme. Further phosphorylation by CDK1 partially reactivates CSK-inactivated SRC and facilitates complete reactivation by protein tyrosine phosphatase PTPRC. Integrin engagement stimulates kinase activity. Phosphorylation by PTK2/FAK1 enhances kinase activity. Phosphorylation at Tyr419(Tyr416) increases kinase activity.","Neratinib, Dasatinib, Midostaurin, Bosutinib, Ponatinib"]
["STAT 3",null,"STAT3","86, 79","rb",null,2,1,".AML., .ANG., .APH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .EGFR., .FOXO., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MIG., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TGFB., .TMAT., .TRASR.","The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors. Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potentia land anti-apoptotic activities. Activation by phosphorylation at Tyr705, induces dimerization, nuclear translocation, and DNA binding.  Transcriptional activation regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways.  MSK1 is necessary for the Ser727 phosphorylation of STAT3"]
["STAT 3 - phospho","Ser727","STAT3","86","rb",null,2,1.1000000000000001,".AML., .ANG., .APH., .CANCER., .CANPTHW., .CCKR., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DEV., .DI., .DRAS., .EGFR., .FOXO., .HEPB., .HIF., .IMFR., .IMU., .IMUF., .IMUR., .INFM., .INS., .INT., .MIG., .NFKB., .NOTCH., .NSCLC., .OP., .OPA., .OT., .PAC., .PDGF., .RAS., .RTK., .SREME., .ST., .STAT., .TCD., .TGFB., .TMAT., .TRASR."," Activation by phosphorylation at Tyr705, induces dimerization, nuclear translocation, and DNA binding.  Transcriptional activation regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways.  MSK1 is necessary for the Ser727 phosphorylation of STAT3."]
["Trk B",null,"NTRK2","145-116, 95-70","ms",null,4,7,".APO., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DRAS., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR.","The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. They are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. Neurotrophin signaling through these receptors regulates  cell survival, proliferation, neural development, and axon and dendrite growth and patterning. The TrkB tyrosine kinase is activated upon binding to BDNF resulting in autophosphorylation of residues Y670, Y674 and Y675 and the subsequent association of several intracellular proteins like PLCγ, Shc, and PI3-Kinase."]
["TSC1 (Hamartin)",null,"TSC1","170-150","rb",null,2,4,".AMPK., .APH., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DMTOR., .DRAS., .IMU., .IMUF., .IMUR., .INS., .MTOR., .OP., .OPA., .OT., .P53S., .PI3K., .RTK., .SREME., .ST., .TCR., .TRASR.","In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 . TSC1 (Hamartin) is phosphorylated by CDK1 (cdc2) at Thr417, Ser584 and Thr1047 in cells in G2/M phase of the cell cycle"]
["TSC2 (Tuberin)",null,"TSC2","200","rb",null,2,1,".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. TSC2 (Tuberin) is directly phosphorylated at Thr1462 by Akt/PKB  which together with phosphorylation at Tyr1571 regulates tuberin-hamartin complexes and tuberin activity."]
["TSC2 (Tuberin) - phospho","Ser1254","TSC2","200","rb",null,4,4,".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","p38-activated kinase MK2 (MAPKAPK-2) phosphorylates Ser1254 of tuberin, and thus augments the interaction between tuberin and 14-3-3."]
["TSC2 (Tuberin) - phospho","Ser1387","TSC2","200","rb",null,2,1,".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D100., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","Phosphorylation of tuberin by AMPK at Ser1387 is necessary for cell size control in response to energy deprivation and protects from apoptosis and primes TSC2 for phosphorylation by GSK3 at upstream sites (Ser1383, Ser1379 and Ser1375), integrating Wnt signaling."]
["TSC2 (Tuberin) - phospho","Ser664","TSC2","200","rb",null,4,4,".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","Erk1/2 phosphorylates of TSC2 at Ser664 which leads to TSC1-TSC2 dissociation and considerably decreases the ability of TSC2 to inhibit mTOR signaling, cell proliferation and oncogenic transformation. Cancer patients with TSC2 phosphorylation at Ser664 may benefit from MAPK and mTOR inhibitors."]
["TSC2 (Tuberin) - phospho","Ser939","TSC2","200","rb",null,4,4,".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","Tuberin is phosphorylated on Ser939 and Thr1462 in response to PI3K activation;  possible involvement of the tuberin-hamartin complex in the PI3K/Akt mediated insulin pathway "]
["TSC2 (Tuberin) - phospho","Tyr1571","TSC2","200","rb",null,4,2,".AMPK., .APH., .APO., .CCP., .CCY., .CD., .CP., .CSP., .CUR., .D200., .D300., .DAKT., .DEV., .DMTOR., .DRAS., .INS., .MTOR., .OP., .OPA., .P53S., .PI3K., .RTK., .SREME., .ST., .WNT.","TSC2 (Tuberin) is directly phosphorylated at Thr1462 by Akt/PKB  which together with phosphorylation at Tyr1571 regulates tuberin-hamartin complexes and tuberin activity."]
["ULK1",null,"ULK1","150","rb",null,2,4,".ALZ., .AMPK., .APH., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .HUNT., .MTOR., .OP., .OPA., .RTK., .SREME., .ST.","ULK1 is essential for autophagy and can act as a convergence point for multiple signals that control autophagy."]
["ULK1 - phospho","Ser555","ULK1","150-140","rb",null,4,4,".ALZ., .AMPK., .APH., .CCP., .CD., .CP., .CSP., .CUR., .D200., .D300., .DI., .DMTOR., .HUNT., .MTOR., .OP., .OPA., .RTK., .SREME., .ST.","ULK1 is phosphorylated by AMPK at Ser555; critical for starvation-induced autophagy, cell survival under conditions of low nutrients and energy, and mitochondiral homeostasis "]
["VEGF-A",null,"VEGFA","45","ms",null,2,7,".ANG., .APO., .BLC., .CANCER., .CANPTHW., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DRAS., .EGFR., .HIF., .IMUR., .LMIG., .MAPK., .MIG., .OP., .OPA., .OT., .P38., .PAC., .PI3K., .RAS., .RCC., .RTK., .SREME., .ST., .STAT., .TRASR., .VEGFS.","Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.","Ziv-Aflibercept, Bevacizumab, Vandetanib"]
["VEGFR 2 (FLK-1)",null,"KDR","230, 210","rb",null,2,7,".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of DAG  and IP3 and the activation of PKC. Mediates activation of ERK1/2 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of NO by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.\nPresent in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues","Cabozantinib, Neratinib, Pazopanib, Sunitinib, Axitinib, Ramucirumab, Azacitidine, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib"]
["VEGFR 2 (FLK-1)- phospho","Tyr1059","KDR","230","rb",null,4,4,".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 ","Cabozantinib, Neratinib, Pazopanib, Sunitinib, Axitinib, Ramucirumab, Azacitidine, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib"]
["VEGFR 2 (FLK-1)- phospho","Tyr1175","KDR","230","rb",null,4,4,".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","Phosphorylation at Tyr1212 provides a docking site for GRB2 binding and phospho-Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ, as well as Shb.","Cabozantinib, Neratinib, Pazopanib, Sunitinib, Axitinib, Ramucirumab, Azacitidine, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib"]
["VEGFR 2 (FLK-1)- phospho","Tyr951","KDR","230","rb",null,4,4,".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 ","Cabozantinib, Neratinib, Pazopanib, Sunitinib, Axitinib, Ramucirumab, Azacitidine, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib"]
["VEGFR 2 (FLK-1)- phospho","Tyr996","KDR","230","rb",null,4,7,".ANG., .APH., .APO., .BMP., .CANCER., .CCP., .CD., .CP., .CSP., .CUR., .D300., .DAKT., .DEV., .DRAS., .EGFR., .MAPK., .MIG., .OP., .OPA., .OT., .PI3K., .RAS., .RTK., .ST., .TRASR., .VEGFS.","Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 ","Cabozantinib, Neratinib, Pazopanib, Sunitinib, Axitinib, Ramucirumab, Azacitidine, Vandetanib, Midostaurin, Regorafenib, Ponatinib, Lenvatinib"]
["zap 70 - phospho","Tyr319/Syk Tyr352","ZAP70","72, 70","rb",null,2,4,".CSP., .CUR., .D300., .DAKT., .DRAS., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to TCR. As a result, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck. Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia.\nPhosphorylation of Tyr493 within the activation loop results in enzymatic activation of Zap-70.\nSyk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells and interacts with immunoreceptor tyrosine-based activation motifs (ITAMs) located in the cytoplasmic domains of immune receptors.It couples the activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.\nTyr323 is a negative regulatory phosphorylation site and provides a direct binding site for the TKB domain of Cbl. Tyr352 of Syk is involved in the association of PLCγ1. Tyr525 and Tyr526 are located in the activation loop and their phosphorylation is essential for Syk function."]
["zap 70 - phospho","Tyr319/Syk Tyr352","ZAP70","72, 70","rb",null,1.1000000000000001,4,".CSP., .CUR., .D300., .DAKT., .DRAS., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to TCR. As a result, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck. Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia.\nPhosphorylation of Tyr493 within the activation loop results in enzymatic activation of Zap-70.\nSyk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells and interacts with immunoreceptor tyrosine-based activation motifs (ITAMs) located in the cytoplasmic domains of immune receptors.It couples the activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.\nTyr323 is a negative regulatory phosphorylation site and provides a direct binding site for the TKB domain of Cbl. Tyr352 of Syk is involved in the association of PLCγ1. Tyr525 and Tyr526 are located in the activation loop and their phosphorylation is essential for Syk function."]
["zap 70 - phospho","Tyr493/Syk Tyr526","ZAP70","70","rb",null,4,4,".CSP., .CUR., .D300., .DAKT., .DRAS., .IIR., .IMU., .IMUF., .IMUR., .NFKB., .OP., .OPA., .RAS., .RTK., .ST., .TCD., .TCR., .TMAT.","The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to TCR. As a result, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck. Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia.\nPhosphorylation of Tyr493 within the activation loop results in enzymatic activation of Zap-70.\nSyk is a protein tyrosine kinase that plays an important role in intracellular signal transduction in hematopoietic cells and interacts with immunoreceptor tyrosine-based activation motifs (ITAMs) located in the cytoplasmic domains of immune receptors.It couples the activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.\nTyr323 is a negative regulatory phosphorylation site and provides a direct binding site for the TKB domain of Cbl. Tyr352 of Syk is involved in the association of PLCγ1. Tyr525 and Tyr526 are located in the activation loop and their phosphorylation is essential for Syk function."]